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Conserved domains on  [gi|2455770201|ref|WP_275452985|]
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helix-turn-helix domain-containing protein [Lacticaseibacillus pantheris]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
9-61 4.84e-20

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 75.67  E-value: 4.84e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2455770201   9 VCHLRRGKMRPGEPLRAIHTITQKMLTQQLRELENEGIVHREVYGQGPPRFVY 61
Cdd:COG1733    28 LRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEY 80
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
9-61 4.84e-20

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 75.67  E-value: 4.84e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2455770201   9 VCHLRRGKMRPGEPLRAIHTITQKMLTQQLRELENEGIVHREVYGQGPPRFVY 61
Cdd:COG1733    28 LRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEY 80
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 9-61 1.17e-18

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 71.95  E-value: 1.17e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 2455770201  9 VCHLRRGKMRPGEPLRAIHTITQKMLTQQLRELENEGIVHREVYGQGPPRFVY 61
Cdd:pfam01638 11 LRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEY 63
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 9-62 6.51e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 31.28  E-value: 6.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 2455770201  9 VCHLRRGKMRPGEpLRAIHTITQKMLTQQLRELENEGIVHREVYGqgppRFVYW 62
Cdd:NF033788  17 LELLAEGELCVCE-LAEALGLSQSAVSQHLKVLRDAGLVTSRREG----RWVYY 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
9-61 9.59e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 30.64  E-value: 9.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2455770201   9 VCHLRRGKMRPGEpLRAIHTITQKMLTQQLRELENEGIVhrEVYGQGPPRFVY 61
Cdd:smart00418  3 LKLLAEGELCVCE-LAEILGLSQSTVSHHLKKLREAGLV--ESRREGKRVYYS 52
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
9-61 4.84e-20

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 75.67  E-value: 4.84e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2455770201   9 VCHLRRGKMRPGEPLRAIHTITQKMLTQQLRELENEGIVHREVYGQGPPRFVY 61
Cdd:COG1733    28 LRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEY 80
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 9-61 1.17e-18

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 71.95  E-value: 1.17e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 2455770201  9 VCHLRRGKMRPGEPLRAIHTITQKMLTQQLRELENEGIVHREVYGQGPPRFVY 61
Cdd:pfam01638 11 LRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEY 63
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 9-62 6.51e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 31.28  E-value: 6.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 2455770201  9 VCHLRRGKMRPGEpLRAIHTITQKMLTQQLRELENEGIVHREVYGqgppRFVYW 62
Cdd:NF033788  17 LELLAEGELCVCE-LAEALGLSQSAVSQHLKVLRDAGLVTSRREG----RWVYY 65
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
9-62 7.62e-03

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 31.40  E-value: 7.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 2455770201  9 VCHLRRGKMRPGEpLRAIHTITQKMLTQQLRELENEGIVHREVYGqgppRFVYW 62
Cdd:COG0640   26 LRLLAEGELCVGE-LAEALGLSQSTVSHHLKVLREAGLVTSRREG----RWVYY 74
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
9-61 9.59e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 30.64  E-value: 9.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2455770201   9 VCHLRRGKMRPGEpLRAIHTITQKMLTQQLRELENEGIVhrEVYGQGPPRFVY 61
Cdd:smart00418  3 LKLLAEGELCVCE-LAEILGLSQSTVSHHLKKLREAGLV--ESRREGKRVYYS 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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