NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2486225276|ref|WP_278960247|]
View 

adenylosuccinate synthase [Lactobacillus apis]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10011626)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  3.40.440.10|3.90.170.10|1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0044208|GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  8244965|11916378|6347525|10218106
SCOP:  4003995

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-428 0e+00

adenylosuccinate synthetase; Provisional


:

Pssm-ID: 234904  Cd Length: 430  Bit Score: 803.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   1 MTAVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLL 80
Cdd:PRK01117    1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  81 GEVESLEESGIDT-SKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEK 159
Cdd:PRK01117   81 KEIDELEARGVDVrERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 160 LRANLKEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTS 239
Cdd:PRK01117  161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 240 SNSISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKR 319
Cdd:PRK01117  241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 320 VSGINGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNR 399
Cdd:PRK01117  321 VNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKR 400

                         410       420
                  ....*....|....*....|....*....
gi 2486225276 400 ISELVDIPLVTVSVGPEREQTIVLRNPWE 428
Cdd:PRK01117  401 IEELTGVPISIISTGPDRDQTIILRDPFA 429
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-428 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 803.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   1 MTAVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLL 80
Cdd:PRK01117    1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  81 GEVESLEESGIDT-SKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEK 159
Cdd:PRK01117   81 KEIDELEARGVDVrERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 160 LRANLKEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTS 239
Cdd:PRK01117  161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 240 SNSISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKR 319
Cdd:PRK01117  241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 320 VSGINGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNR 399
Cdd:PRK01117  321 VNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKR 400

                         410       420
                  ....*....|....*....|....*....
gi 2486225276 400 ISELVDIPLVTVSVGPEREQTIVLRNPWE 428
Cdd:PRK01117  401 IEELTGVPISIISTGPDRDQTIILRDPFA 429
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 3-424 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 768.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   3 AVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGE 82
Cdd:COG0104     1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  83 VESLEESGIDT-SKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLR 161
Cdd:COG0104    81 IDGLEARGVDVrSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 162 ANLKEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSN 241
Cdd:COG0104   161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 242 SISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVS 321
Cdd:COG0104   241 TTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRIN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 322 GINGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRIS 401
Cdd:COG0104   321 GLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIE 400

                         410       420
                  ....*....|....*....|...
gi 2486225276 402 ELVDIPLVTVSVGPEREQTIVLR 424
Cdd:COG0104   401 ELLGVPISIVSVGPDREQTIVRR 423
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
5-421 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 744.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   5 AVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGEVE 84
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  85 SLEESGID-TSKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLRAN 163
Cdd:pfam00709  81 ELEERGIDvPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 164 LKEKNELFTKVYGkDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSNSI 243
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 244 SGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVSGI 323
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 324 NGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRISEL 403
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEEL 399

                         410
                  ....*....|....*...
gi 2486225276 404 VDIPLVTVSVGPEREQTI 421
Cdd:pfam00709 400 LGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 3-422 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 702.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276    3 AVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGE 82
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   83 VESLEESGID-TSKLKISNRAHIIMPYHILQDEYQEEAKgankIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLR 161
Cdd:smart00788  81 IEELEAKGVDvKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  162 ANLKEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSN 241
Cdd:smart00788 157 ELLDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  242 SISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVS 321
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  322 GINGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRIS 401
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIE 396

                          410       420
                   ....*....|....*....|.
gi 2486225276  402 ELVDIPLVTVSVGPEREQTIV 422
Cdd:smart00788 397 ELVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 6-426 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 572.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   6 VVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGEVES 85
Cdd:TIGR00184   2 VVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEMEY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  86 LEESGIDT-SKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLRANL 164
Cdd:TIGR00184  82 LEKRGISVrDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNIL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 165 KEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSNSIS 244
Cdd:TIGR00184 162 EYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTTA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 245 GGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVSGIN 324
Cdd:TIGR00184 242 GGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGAT 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 325 GLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRISELV 404
Cdd:TIGR00184 322 QLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEELT 401

                         410       420
                  ....*....|....*....|..
gi 2486225276 405 DIPLVTVSVGPEREQTIVLRNP 426
Cdd:TIGR00184 402 GVPVTIISTGPEREQTIDLRKE 423
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 3-422 3.90e-172

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 484.31  E-value: 3.90e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   3 AVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGE 82
Cdd:cd03108     2 VTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  83 VESLEESGID-TSKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDllekdtfeeklr 161
Cdd:cd03108    82 IEELEKKGIDvKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD------------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 162 anlkeknelftkvygkdalkfddifdqyyeygqkmkKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSN 241
Cdd:cd03108   150 ------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSSN 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 242 SISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVS 321
Cdd:cd03108   194 TTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRIN 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 322 GINGLSLNLLDIfsgfdtvkiatayeldgkeidyypaslkeldrckpvyeelpawqeditgakswddlpeNAQKFLNRIS 401
Cdd:cd03108   274 GLTELALTKLDV----------------------------------------------------------NAQKYIERIE 295

                         410       420
                  ....*....|....*....|.
gi 2486225276 402 ELVDIPLVTVSVGPEREQTIV 422
Cdd:cd03108   296 ELLGVPITYISVGPDREQTII 316
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
3-322 2.18e-42

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 150.98  E-value: 2.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   3 AVAVVGSQWGDEGKGKITDFLSKEAAYAVRSN-GGNNAGHTIeIDDQ--TFKMRLIPSGI-FASAKGAVIGNGVVINPEV 78
Cdd:NF038379    1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTY-IDDEgrKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  79 LLGEVESLEESGIDTSK-LKISNRAHIIMpyhiLQDEYQEEAKGANKIGTTKNGIGPAYMDK----ASRVGIRVCDLLEK 153
Cdd:NF038379   80 LREEIEELEDAGHDVGKrLLIHEQATVIE----LHKHVEEEAGPMTKIGSTKKGIGAARAAKirrnPSTLGDAEGDFGEG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 154 DTFEEKLRanlkeknelftkvygkdalkFDDIFDQYYEYGQkmkkyvtdtsvlvndALDNNEKVLFEGAQGIMLDIDEGT 233
Cdd:NF038379  156 AVRDQPWE--------------------IAERVVDNALYDF---------------ALQAAERIQIEGTQGYSLGLHAGF 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 234 YPFVTSSNSISGGIASGMGV--GANRLNTVIGVCKAYTTRVGA-----GPFPTELNDEtgDLIRETahEYGTVTGRPRRV 306
Cdd:NF038379  201 YPYCTSRDCTPADFLADAGIplPNVDAFKVVGTARTYPIRVAGwsgnsYPDQGETTWE--ELGLPE--ELTTVTKKVRRV 276

                         330
                  ....*....|....*.
gi 2486225276 307 GWFDSVALRHAKRVSG 322
Cdd:NF038379  277 GTFSAEQVREAVQANG 292
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-428 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 803.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   1 MTAVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLL 80
Cdd:PRK01117    1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  81 GEVESLEESGIDT-SKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEK 159
Cdd:PRK01117   81 KEIDELEARGVDVrERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 160 LRANLKEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTS 239
Cdd:PRK01117  161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 240 SNSISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKR 319
Cdd:PRK01117  241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 320 VSGINGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNR 399
Cdd:PRK01117  321 VNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKR 400

                         410       420
                  ....*....|....*....|....*....
gi 2486225276 400 ISELVDIPLVTVSVGPEREQTIVLRNPWE 428
Cdd:PRK01117  401 IEELTGVPISIISTGPDRDQTIILRDPFA 429
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 3-424 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 768.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   3 AVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGE 82
Cdd:COG0104     1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  83 VESLEESGIDT-SKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLR 161
Cdd:COG0104    81 IDGLEARGVDVrSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 162 ANLKEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSN 241
Cdd:COG0104   161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 242 SISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVS 321
Cdd:COG0104   241 TTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRIN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 322 GINGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRIS 401
Cdd:COG0104   321 GLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIE 400

                         410       420
                  ....*....|....*....|...
gi 2486225276 402 ELVDIPLVTVSVGPEREQTIVLR 424
Cdd:COG0104   401 ELLGVPISIVSVGPDREQTIVRR 423
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
5-421 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 744.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   5 AVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGEVE 84
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  85 SLEESGID-TSKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLRAN 163
Cdd:pfam00709  81 ELEERGIDvPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 164 LKEKNELFTKVYGkDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSNSI 243
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 244 SGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVSGI 323
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 324 NGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRISEL 403
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEEL 399

                         410
                  ....*....|....*...
gi 2486225276 404 VDIPLVTVSVGPEREQTI 421
Cdd:pfam00709 400 LGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 3-422 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 702.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276    3 AVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGE 82
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   83 VESLEESGID-TSKLKISNRAHIIMPYHILQDEYQEEAKgankIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLR 161
Cdd:smart00788  81 IEELEAKGVDvKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  162 ANLKEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSN 241
Cdd:smart00788 157 ELLDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  242 SISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVS 321
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  322 GINGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRIS 401
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIE 396

                          410       420
                   ....*....|....*....|.
gi 2486225276  402 ELVDIPLVTVSVGPEREQTIV 422
Cdd:smart00788 397 ELVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 6-426 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 572.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   6 VVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGEVES 85
Cdd:TIGR00184   2 VVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEMEY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  86 LEESGIDT-SKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLRANL 164
Cdd:TIGR00184  82 LEKRGISVrDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNIL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 165 KEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSNSIS 244
Cdd:TIGR00184 162 EYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTTA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 245 GGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVSGIN 324
Cdd:TIGR00184 242 GGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGAT 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 325 GLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRISELV 404
Cdd:TIGR00184 322 QLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEELT 401

                         410       420
                  ....*....|....*....|..
gi 2486225276 405 DIPLVTVSVGPEREQTIVLRNP 426
Cdd:TIGR00184 402 GVPVTIISTGPEREQTIDLRKE 423
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 3-422 5.02e-178

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 503.79  E-value: 5.02e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   3 AVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGE 82
Cdd:PTZ00350   14 VVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLLEE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  83 VESLEESGID-TSKLKISNRAHIIMPYHILQDEYQEEAKGAN--KIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEK 159
Cdd:PTZ00350   94 IEQLTKKGINlLGRLYISDRAHLVFDLHQAIDGIQESEKGKGgtQIGTTKRGIGPCYSTKASRTGLRVGDLLNFETFEKK 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 160 LRANLKEKNELFtKVYGKDAlkfDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTS 239
Cdd:PTZ00350  174 YRKLVEKLQEQY-NIEEYDA---EEELERYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGTYPYVTS 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 240 SNSISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKR 319
Cdd:PTZ00350  250 SNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRYVQM 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 320 VSGINGLSLNLLDIFSGFDTVKIATAYELDGK--EIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFL 397
Cdd:PTZ00350  330 INGFDSINLTKLDVLSGLKEIKICVNYKNKGTglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQKYV 409

                         410       420
                  ....*....|....*....|....*
gi 2486225276 398 NRISELVDIPLVTVSVGPEREQTIV 422
Cdd:PTZ00350  410 LFIEELLGVPIVWIGVGPNRENMIV 434
PLN02513 PLN02513
adenylosuccinate synthase
 4-424 7.07e-177

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 500.71  E-value: 7.07e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   4 VAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDD-QTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGE 82
Cdd:PLN02513    5 SAVLGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYNDEgKKFALHLVPSGILNEKTTCVIGNGVVVHLPGLFEE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  83 VESLEESGID-TSKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLR 161
Cdd:PLN02513   85 IDGLESNGVScEGRLLVSDRAHLLFDFHQEVDGLREAELAGSKIGTTKRGIGPAYSSKATRNGLRVGDLRHMDTFAEKLR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 162 ANLKEKNELFTKvYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSN 241
Cdd:PLN02513  165 ELLADAAARFEG-FEYDASMVEEEVEAYKKFAERLEPFITDTVHYLNEAIQAGKKILVEGAQATMLDIDFGTYPFVTSSN 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 242 SISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVS 321
Cdd:PLN02513  244 PSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVALKYSCQIN 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 322 GINGLSLNLLDIFSGFDTVKIATAYEL-DGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRI 400
Cdd:PLN02513  324 GFTSLNLTKLDVLSGLPEIKIGVAYKTpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAAAQAYVERI 403

                         410       420
                  ....*....|....*....|....
gi 2486225276 401 SELVDIPLVTVSVGPEREQTIVLR 424
Cdd:PLN02513  404 EELVGVPVHYIGVGPGRDALIVKP 427
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 3-422 3.90e-172

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 484.31  E-value: 3.90e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   3 AVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLLGE 82
Cdd:cd03108     2 VTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  83 VESLEESGID-TSKLKISNRAHIIMPYHILQDEYQEEAKGANKIGTTKNGIGPAYMDKASRVGIRVCDllekdtfeeklr 161
Cdd:cd03108    82 IEELEKKGIDvKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD------------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 162 anlkeknelftkvygkdalkfddifdqyyeygqkmkKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSN 241
Cdd:cd03108   150 ------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSSN 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 242 SISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVS 321
Cdd:cd03108   194 TTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRIN 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 322 GINGLSLNLLDIfsgfdtvkiatayeldgkeidyypaslkeldrckpvyeelpawqeditgakswddlpeNAQKFLNRIS 401
Cdd:cd03108   274 GLTELALTKLDV----------------------------------------------------------NAQKYIERIE 295

                         410       420
                  ....*....|....*....|.
gi 2486225276 402 ELVDIPLVTVSVGPEREQTIV 422
Cdd:cd03108   296 ELLGVPITYISVGPDREQTII 316
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 6-421 2.04e-153

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 441.16  E-value: 2.04e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   6 VVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKgAVIGNGVVINPEVLLGEVES 85
Cdd:PRK13786    5 ITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFLLDAR-VLIGPGVVLNPEVLAEEIDM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  86 LEESGI--DTSKLKISNRAHIIMPYHILQDEYQEEAKGAnKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLRAN 163
Cdd:PRK13786   84 LEKHGVkvDAEKLGIDAKTSIIMPYHIELDGLRESARTE-KIGTTKRGIGFAYIDKIARDEVRMSDLVDKERLMRRLEEL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 164 LKEKNELFTKVYGKDALKFDD-IFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTSSNS 242
Cdd:PRK13786  163 APQKEKEIKELGGDPSIVRDEaLIDKYLELGRQLAPYITDVSYEINKALDEGKSVLAEGAQGTHLDVIHGTQKFVTSSST 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 243 ISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKRVSG 322
Cdd:PRK13786  243 IAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLKKAIYLNG 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 323 INGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLNRISE 402
Cdd:PRK13786  323 YTEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARNYVERLEE 402

                         410
                  ....*....|....*....
gi 2486225276 403 LVDIPLVTVSVGPEREQTI 421
Cdd:PRK13786  403 LMGVPIKYISVGPGREQTF 421
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 1-427 1.02e-140

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 409.92  E-value: 1.02e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   1 MTaVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIfASAKGAVIGNGVVINPEVLL 80
Cdd:PRK13785    1 MT-VTIVGSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGA-VRGKIGVLGNGCVVNPETLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  81 GEVESLEESGIDTSkLKISNRAHIIMPYHILQDEYQEEAKGAN--KIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEE 158
Cdd:PRK13785   79 DEIDALRERGLDPD-VRVAERAHVILPYHRVLDGIEEEAKSDSdlEVGTTGRGIGPTYEDKAGRRGVRVGDLLDPDVLRD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 159 KLRANLKEKNELFTKVYGKD------ALKFDDIFDQYYEYGQKMKK--YVTDTSVLVNDALDNNEKVLFEGAQGIMLDID 230
Cdd:PRK13785  158 RLEYVVPQKRALAEDVYGLDasetpeAFDVDALFEEYREYGERLAEedMTVNAGDFLAERIDDGDNVMLEGAQGTSIDID 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 231 EGTYPFVTSSNSISGGIASGMGVGANRL--NTVIGVCKAYTTRVGAGPFPTEL---------------NDETGDLIRETA 293
Cdd:PRK13785  238 HGNYPYVTSSNPTAGGAATGTGLGPTVVgqGEVVGIVKAYLSRVGSGPLPTELggvegdtpdeggrpdEEELATYIREEG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 294 HEYGTVTGRPRRVGWFDSVALRHAKRVSGINGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPASLKELDRCKPVYEEL 373
Cdd:PRK13785  318 GEYGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEPNFRSF 397

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2486225276 374 PAWQE---DITGAKSWDDLPENAQKFLNRISELVDIPLVTVSVGPEREQTIVLRNPW 427
Cdd:PRK13785  398 DGWPEvdwAAVAEEGYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVLENPF 454
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 1-423 3.21e-139

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 405.10  E-value: 3.21e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   1 MTAVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLL 80
Cdd:PRK13787    1 MPASLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  81 GEVESLEESGIDT-SKLKISNRAHIIMPYHILQDEYQEEAKGA-NKIGTTKNGIGPAYMDKASRVGIRVCDLLEKdTFEE 158
Cdd:PRK13787   81 EECDRLQKEGFPVkDKLLLSDACHLLFPYHSQIDSARETTSSQeHKIGTTKKGIGICYADKMMRTGLRVGDLLDK-SYKR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 159 KLRANLKEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVT 238
Cdd:PRK13787  160 RLKHLVDEKNRELDKLYGMPPVSYNDINDGLKFFLSKVGKNIINTAYYLDTELKKGKRVLLEGAQGTGLDVDFGTYPYVT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 239 SSNSISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAK 318
Cdd:PRK13787  240 SSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEMLKHSV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 319 RVSGINGLSLNLLDIFSGFDTVKIATAYELDGKEIDYYPAslKELDRCKPVYEELPAWQEDITGAKSWDDLPENAQKFLN 398
Cdd:PRK13787  320 RINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPS--QGLEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNYIS 397

                         410       420
                  ....*....|....*....|....*
gi 2486225276 399 RISELVDIPLVTVSVGPEREQTIVL 423
Cdd:PRK13787  398 ALEKWIGVKINLVSTGPDRKDTIIG 422
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 1-420 8.25e-139

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 403.03  E-value: 8.25e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   1 MTAVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLL 80
Cdd:PRK13788    1 MPGIAIIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  81 GEVESLEESGIDtSKLKISNRAHIIMPYHILQDEyqeeakGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKL 160
Cdd:PRK13788   81 EERENLRAGGLN-PKLLISERAHLVLPHHKYVDG------RKNFVGTTGRGIGPAYSDRARRVGIRFGDLLDEAVLRERV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 161 RANLKEK-NElfTKVYGKDALkfDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVTS 239
Cdd:PRK13788  154 ERLLEAKpNS--TREAGWDTV--EKALADLAPMREILLPFIADTGSLLREAIREGKRVLFEGAQATLLDLNYGTYPYVTS 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 240 SNSISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETA----HEYGTVTGRPRRVGWFDSVALR 315
Cdd:PRK13788  230 SHPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLLK 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 316 HAKRVSGINGLSLNLLDIFSGFDTVKIATAYELDGkeidyypaslkeldrcKPVYEELPAWQeDITGAKSWDDLPENAQK 395
Cdd:PRK13788  310 YACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDG----------------QPVYKELPGWG-DLDGVKSREALPKEAQA 372

                         410       420
                  ....*....|....*....|....*
gi 2486225276 396 FLNRISELVDIPLVTVSVGPEREQT 420
Cdd:PRK13788  373 YLELIEETTGVPVVMFSTSPRREDT 397
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 5-421 1.36e-136

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 397.55  E-value: 1.36e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   5 AVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDqtFKM--RLIPSGIFASAKGAVIGNGVVINPEVLLGE 82
Cdd:PRK13783    4 VIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGD--FKVvhHLLPSADFKKNVGAAIGNGVVLDLEVLVEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  83 VESLEESGIDTS-KLKISNRAHIIMPYHILQDEYQEEAKGaNKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEEKLR 161
Cdd:PRK13783   82 LEELKEKFPDYSgRIFISELAHVVLPVHKELDEIIESVRK-NAIGTTKRGIGPAYADKVMRVGVRLADLFDEEKLREFLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 162 ANLKekneLFTKVYGkdaLKFD--DIFDQYYEYGQKMKKYVTDTSVLVNdaLDNNEKVLFEGAQGIMLDIDEGTYPFVTS 239
Cdd:PRK13783  161 KILS----LYKKLYG---IEFDveKMMEDLLTFYEKIKDLVVSPVEIKR--ILEEKSVLFEGTQGVLLDLDVGTYPYVTS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 240 SNSISGGIASGMGVGAnRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAKR 319
Cdd:PRK13783  232 SNCSTTGVSAGMGFPV-KVDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIE 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 320 VSGINGLSLNLLDIFSGFDTVKIATAYELDGKEIDyYPASLKELDRCKPVYEELPAWqeditgaKSWDDlpENAQKFLNR 399
Cdd:PRK13783  311 VSGVDSLVMTKADVLNGFEKIKVCVRYEIGGKEVR-DPSSLRDLEKAEPVYEEFDGW-------KSLED--KNFLKFVDF 380

                         410       420
                  ....*....|....*....|..
gi 2486225276 400 ISELVDIPLVTVSVGPEREQTI 421
Cdd:PRK13783  381 IERETGRKIAYISTGPKIEEIV 402
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 1-425 5.34e-106

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 320.43  E-value: 5.34e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   1 MTAVAVVGSQWGDEGKGKITDFLSKEAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLL 80
Cdd:PRK13784    1 MSNIVIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  81 GEVESLEESGIDTS--KLKISNRAHIIMPYHILQDEYQEEAKgANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKDTFEE 158
Cdd:PRK13784   81 EEITRLQAKGIAISaeNLFVSESCTIITSYHKLLDAVRESNT-SEKIGTTGKGIGPAYEDKVSRKGIKFKHLFDKDLLRS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 159 KLRANLKEKNELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFVT 238
Cdd:PRK13784  160 RLAISLAEKETLFRDLYKVEYPTLEQEFDKLFALGQKLKQYAADTFSIIDQAIAAGKNVVYEGAQGVLLDVDYGTYPFVT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 239 SSNSISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNDETGDLIRETAHEYGTVTGRPRRVGWFDSVALRHAK 318
Cdd:PRK13784  240 SSNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 319 RVSGINGLSLNLLDIFSGFDTVKIATAYELDGKEID-YYPASlkELDRCKPVYEELPAWQEDITGAKswDDLPENAQKFL 397
Cdd:PRK13784  320 KCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEIYcAYPGI--DLYKVEPILVEMEPFSIDETVTK--DNMPAALKTYL 395

                         410       420
                  ....*....|....*....|....*...
gi 2486225276 398 NRISELVDIPLVTVSVGPEREQTIVLRN 425
Cdd:PRK13784  396 KTIENHVGIPISSLAYGPSREQILFFED 423
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 1-424 7.32e-86

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 265.21  E-value: 7.32e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   1 MTAVAVVGSQWGDEGKGKITDFLSK--EAAYAVRSNGGNNAGHTIEIDDQTFKMRLIPSG-IFASAKGAvIGNGVVINPE 77
Cdd:PRK04293    1 MTCTIVVGGFFGDEGKGKIIAYLALkdKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGfVNKDAKLA-IGAGVLVDPE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  78 VLLGEVESLEESGidtsKLKISNRAHIIMPYHILQDeyQEEAKGANKIGTTKNGIGPAYMDKASRVGirvcdLLEKDtFE 157
Cdd:PRK04293   80 VLLKEVEELNVGG----RVFVDYRCGIIEEKHVEED--RSDEHLSKKIGSTGTGCGPANADRVLRRL-----KLAKD-VE 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 158 EklranlkeknelftkvygkdalkfddifdqyyeygqkMKKYVTDTSVLVNDALDNNEKVLFEGAQGIMLDIDEGTYPFV 237
Cdd:PRK04293  148 E-------------------------------------LEKYLTDVPEEVNEALDRGENVLIEGTQGFGLSLYYGTYPYV 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 238 TSSNSISGGIASGMGVGANRLNTVIGVCKAYTTRVGAGPFPTELNdetgdliRETAH-----EYGTVTGRPRRVGWFDsv 312
Cdd:PRK04293  191 TSKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELS-------LEEAEklglvEYGTVTGRRRRVGPFD-- 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 313 aLRHAKRVSGINGlslnlldifsgfdtvkiATAyeldgkeidyypASLKELDRCKPvyeelpawqeDITGAKSWDDLPEN 392
Cdd:PRK04293  262 -FELARRAARING-----------------ATQ------------IAITKLDKLDK----------EAYGVTEYDKLPPE 301

                         410       420       430
                  ....*....|....*....|....*....|..
gi 2486225276 393 AQKFLNRISELVDIPLVTVSVGPEREQTIVLR 424
Cdd:PRK04293  302 AKKFIEEIEEELGVPVTLISTGPELEDTIDLR 333
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
3-322 2.18e-42

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 150.98  E-value: 2.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   3 AVAVVGSQWGDEGKGKITDFLSKEAAYAVRSN-GGNNAGHTIeIDDQ--TFKMRLIPSGI-FASAKGAVIGNGVVINPEV 78
Cdd:NF038379    1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTY-IDDEgrKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  79 LLGEVESLEESGIDTSK-LKISNRAHIIMpyhiLQDEYQEEAKGANKIGTTKNGIGPAYMDK----ASRVGIRVCDLLEK 153
Cdd:NF038379   80 LREEIEELEDAGHDVGKrLLIHEQATVIE----LHKHVEEEAGPMTKIGSTKKGIGAARAAKirrnPSTLGDAEGDFGEG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 154 DTFEEKLRanlkeknelftkvygkdalkFDDIFDQYYEYGQkmkkyvtdtsvlvndALDNNEKVLFEGAQGIMLDIDEGT 233
Cdd:NF038379  156 AVRDQPWE--------------------IAERVVDNALYDF---------------ALQAAERIQIEGTQGYSLGLHAGF 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 234 YPFVTSSNSISGGIASGMGV--GANRLNTVIGVCKAYTTRVGA-----GPFPTELNDEtgDLIRETahEYGTVTGRPRRV 306
Cdd:NF038379  201 YPYCTSRDCTPADFLADAGIplPNVDAFKVVGTARTYPIRVAGwsgnsYPDQGETTWE--ELGLPE--ELTTVTKKVRRV 276

                         330
                  ....*....|....*.
gi 2486225276 307 GWFDSVALRHAKRVSG 322
Cdd:NF038379  277 GTFSAEQVREAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 4-424 9.58e-20

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 91.65  E-value: 9.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276   4 VAVVGSQWGDEGKGKITDFLSKE--AAYAVRSNGGNNAGHTI-EIDDQTFKMRLIPSGIFASAKGAVIGNGVVINPEVLL 80
Cdd:PTZ00351  172 IMVAGAFFGDEGKGKTVDAVAHHplCTCIARVNSGENAGHTVyDKAGRKFVFNLAPSGLLLPGKRNYIGPECVMDPVSFM 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276  81 -GEVESLEESGID-TSKLKISNRAhIIMPYHILQDeyqeeAKGANKIGTTKNGIGPAYMDKASRVGIRVCDLLEKD-TFE 157
Cdd:PTZ00351  252 eKEIIQLIDAGIDyRDRLFIGNVC-IVTPYHKLLD-----LLGSAANSSTLKGMAPVHGSKVMKRGIRLDHIFNDDeTLR 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 158 EKLRAN-------LKEKN-------ELFTKVYGKDALKFDDIFDQYYEYGQKMKKYVT----------------DTSVLV 207
Cdd:PTZ00351  326 KRLEKDmdtylglLKVKNlsdadvvRLCREENSDGVVRVPDYVIAFAQAKDKVEFLVKlyrdrvrhnpdfparcDVTYEL 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 208 NDALDNNEKVLFEGAQGIML-DIDEGTYPFVTSSNSISGGIASGMGVGANRLNTVI-GVCKAY-TTRVGAG--------- 275
Cdd:PTZ00351  406 HAAVLRGEKVLLEGPQSYWLsNARTKFWESTTSADTTAAGLLAASQLNFQKFKSVVlNVHKAPgSSRVGIGacpssfvpq 485

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 276 ----------------------------------PF------------PTELNDETGDL-------IRETAH--EYGTVT 300
Cdd:PTZ00351  486 dyfsaqniktlrdlpsatcanfeavqrtlfrdgfPHsndkarhngimaPVEYSDETGDYnigvamaIASAQHhgECGAVT 565

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486225276 301 GRPRRVGWFDSVaLRHakRVSGING--LSLNLLDIFSGFDTVKIATA---YELDGKEIDYYPASLKELD----------- 364
Cdd:PTZ00351  566 KKPRVCGFFDCV-LQH--EVNSIQGpyLTISALDRGDEYDKVGVTIAyvyYNPEGKQVDVNGHVYKNGDiiragdpvpse 642

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2486225276 365 ----RCKPVYEELPAWQED-ITGAKSWDD--LPENAQKFLNRISELVDIPLVTVSVGPEREQTIVLR 424
Cdd:PTZ00351  643 palyHCHPIVKLIDGWRDNpIAAAKRRRNapLPRGVCELLSTIEYFTNCKILSIGNGPNGDDIIYLR 709
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH