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Conserved domains on  [gi|2494728092|ref|WP_279622877|]
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S-formylglutathione hydrolase [Actinobacillus equuli]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 1-278 1.28e-145

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PLN02442:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 283  Bit Score: 409.94  E-value: 1.28e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092   1 MTALTQIARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQAEQGqKVPVLYWLSGLTCTDENFATKAGAQQFAAQHGIAI 80
Cdd:PLN02442    2 AAALKEISVNKMFGGFNRRYKHFSSTLGCSMTFSVYFPPASDSG-KVPVLYWLSGLTCTDENFIQKSGAQRAAAARGIAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  81 VMPDTSPRGEAV-ANDEGYDLGQGAGFYLNATQQPWaTHFKMYDYIVQELPALIEANFPVSD--KRSISGHSMGGHGAIQ 157
Cdd:PLN02442   81 VAPDTSPRGLNVeGEADSWDFGVGAGFYLNATQEKW-KNWRMYDYVVKELPKLLSDNFDQLDtsRASIFGHSMGGHGALT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 158 IGLKNPERYCAISAFSPIVTPSQVPWGQKAFTAYLGENQTAWAEYDSFALLDNVSPAR-PILIEQGLADSFYPTQLQPEI 236
Cdd:PLN02442  160 IYLKNPDKYKSVSAFAPIANPINCPWGQKAFTNYLGSDKADWEEYDATELVSKFNDVSaTILIDQGEADKFLKEQLLPEN 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2494728092 237 FTEKAKKLGLDVTLNLHEGYDHSYFFIASFIEKHIVFHARAL 278
Cdd:PLN02442  240 FEEACKEAGAPVTLRLQPGYDHSYFFIATFIDDHINHHAQAL 281
 
Name Accession Description Interval E-value
PLN02442 PLN02442
S-formylglutathione hydrolase
 1-278 1.28e-145

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 409.94  E-value: 1.28e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092   1 MTALTQIARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQAEQGqKVPVLYWLSGLTCTDENFATKAGAQQFAAQHGIAI 80
Cdd:PLN02442    2 AAALKEISVNKMFGGFNRRYKHFSSTLGCSMTFSVYFPPASDSG-KVPVLYWLSGLTCTDENFIQKSGAQRAAAARGIAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  81 VMPDTSPRGEAV-ANDEGYDLGQGAGFYLNATQQPWaTHFKMYDYIVQELPALIEANFPVSD--KRSISGHSMGGHGAIQ 157
Cdd:PLN02442   81 VAPDTSPRGLNVeGEADSWDFGVGAGFYLNATQEKW-KNWRMYDYVVKELPKLLSDNFDQLDtsRASIFGHSMGGHGALT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 158 IGLKNPERYCAISAFSPIVTPSQVPWGQKAFTAYLGENQTAWAEYDSFALLDNVSPAR-PILIEQGLADSFYPTQLQPEI 236
Cdd:PLN02442  160 IYLKNPDKYKSVSAFAPIANPINCPWGQKAFTNYLGSDKADWEEYDATELVSKFNDVSaTILIDQGEADKFLKEQLLPEN 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2494728092 237 FTEKAKKLGLDVTLNLHEGYDHSYFFIASFIEKHIVFHARAL 278
Cdd:PLN02442  240 FEEACKEAGAPVTLRLQPGYDHSYFFIATFIDDHINHHAQAL 281
fghA_ester_D TIGR02821
S-formylglutathione hydrolase; This model describes a protein family from bacteria, yeast, and ...
 7-278 1.07e-133

S-formylglutathione hydrolase; This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well. [Cellular processes, Detoxification]


Pssm-ID: 131868  Cd Length: 275  Bit Score: 379.51  E-value: 1.07e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092   7 IARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQAEQGQkVPVLYWLSGLTCTDENFATKAGAQQFAAQHGIAIVMPDTS 86
Cdd:TIGR02821   3 ISSHACFGGTQGFYRHKSETCGVPMTFGVFLPPQAAAGP-VPVLWYLSGLTCTHENFMIKAGAQRFAAEHGLALVAPDTS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  87 PRGEAVAN-DEGYDLGQGAGFYLNATQQPWATHFKMYDYIVQELPALIEANFPVS-DKRSISGHSMGGHGAIQIGLKNPE 164
Cdd:TIGR02821  82 PRGTGIAGeDDAWDFGKGAGFYVDATEEPWSQHYRMYSYIVQELPALVAAQFPLDgERQGITGHSMGGHGALVIALKNPD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 165 RYCAISAFSPIVTPSQVPWGQKAFTAYLGENQTAWAEYDSFALLDNVSPARPILIEQGLADSFYPTQLQPEIFTEKAKKL 244
Cdd:TIGR02821 162 RFKSVSAFAPIVAPSRCPWGQKAFSAYLGADEAAWRSYDASLLVADGGRHSTILIDQGTADQFLDEQLRPDAFEQACRAA 241

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2494728092 245 GLDVTLNLHEGYDHSYFFIASFIEKHIVFHARAL 278
Cdd:TIGR02821 242 GQALTLRRQAGYDHSYYFIASFIADHLRHHAERL 275
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
14-278 1.95e-114

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 329.49  E-value: 1.95e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  14 GGYHERYTHYSNSTHCEMTFAIYLPPQAEqGQKVPVLYWLSGLTCTDENFATKAGAQQFAAQHGIAIVMPDtsprgeava 93
Cdd:COG0627     1 GGRVVRVTVPSPALGREMPVSVYLPPGYD-GRPLPVLYLLHGLTGTHENWTRKTGAQRLAAELGVIVVMPD--------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  94 ndegydlGQGAGFYLNATQQPwATHFKMYDYIVQELPALIEANFPVS---DKRSISGHSMGGHGAIQIGLKNPERYCAIS 170
Cdd:COG0627    71 -------GGQASFYVDWTQGP-AGHYRWETYLTEELPPLIEANFPVSadrERRAIAGLSMGGHGALTLALRHPDLFRAVA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 171 AFSPIVTPSQVPWGQKAFTAYLG-ENQTAWAEYDSFALLDNVSPARPILIEQGLADS-FYPTQLQpeiFTEKAKKLGLDV 248
Cdd:COG0627   143 AFSGILDPSQPPWGEKAFDAYFGpPDRAAWAANDPLALAEKLRAGLPLYIDCGTADPfFLEANRQ---LHAALRAAGIPH 219

                         250       260       270
                  ....*....|....*....|....*....|
gi 2494728092 249 TLNLHEGYdHSYFFIASFIEKHIVFHARAL 278
Cdd:COG0627   220 TYRERPGG-HSWYYWASFLEDHLPFLARAL 248
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 24-271 7.92e-69

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 213.48  E-value: 7.92e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  24 SNSTHCEMTFAIYLPPQAEQGQKVPVLYWLSGlTCTDENFATKAGAQQFAAQHGIAIVMPDTSPRGEAVANDEGYDLGqg 103
Cdd:pfam00756   1 SNSLGREMKVQVYLPEDYPPGRKYPVLYLLDG-TGWFQNGPAKEGLDRLAASGEIPPVIIVGSPRGGEVSFYSDWDRG-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 104 agfyLNATQQPWATHFKmyDYIVQELPALIEANFPV-SDKRSISGHSMGGHGAIQIGLKNPERYCAISAFSPIVTPSQVP 182
Cdd:pfam00756  78 ----LNATEGPGAYAYE--TFLTQELPPLLDANFPTaPDGRALAGQSMGGLGALYLALKYPDLFGSVSSFSPILNPSNSM 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 183 WGQkaftaylgENQTAWAEYDSFALLDNVSPARP---ILIEQGLADSFYPTQLQPEI--FTEKAKKLGLDVTLNLHEGYD 257
Cdd:pfam00756 152 WGP--------EDDPAWQEGDPVLLAVALSANNTrlrIYLDVGTREDFLGDQLPVEIleELAPNRELAEQLAYRGVGGYD 223

                         250       260
                  ....*....|....*....|.
gi 2494728092 258 HSY-------FFIASFIEKHI 271
Cdd:pfam00756 224 HEYygghdwaYWRAQLIAALI 244
 
Name Accession Description Interval E-value
PLN02442 PLN02442
S-formylglutathione hydrolase
 1-278 1.28e-145

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 409.94  E-value: 1.28e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092   1 MTALTQIARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQAEQGqKVPVLYWLSGLTCTDENFATKAGAQQFAAQHGIAI 80
Cdd:PLN02442    2 AAALKEISVNKMFGGFNRRYKHFSSTLGCSMTFSVYFPPASDSG-KVPVLYWLSGLTCTDENFIQKSGAQRAAAARGIAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  81 VMPDTSPRGEAV-ANDEGYDLGQGAGFYLNATQQPWaTHFKMYDYIVQELPALIEANFPVSD--KRSISGHSMGGHGAIQ 157
Cdd:PLN02442   81 VAPDTSPRGLNVeGEADSWDFGVGAGFYLNATQEKW-KNWRMYDYVVKELPKLLSDNFDQLDtsRASIFGHSMGGHGALT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 158 IGLKNPERYCAISAFSPIVTPSQVPWGQKAFTAYLGENQTAWAEYDSFALLDNVSPAR-PILIEQGLADSFYPTQLQPEI 236
Cdd:PLN02442  160 IYLKNPDKYKSVSAFAPIANPINCPWGQKAFTNYLGSDKADWEEYDATELVSKFNDVSaTILIDQGEADKFLKEQLLPEN 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2494728092 237 FTEKAKKLGLDVTLNLHEGYDHSYFFIASFIEKHIVFHARAL 278
Cdd:PLN02442  240 FEEACKEAGAPVTLRLQPGYDHSYFFIATFIDDHINHHAQAL 281
fghA_ester_D TIGR02821
S-formylglutathione hydrolase; This model describes a protein family from bacteria, yeast, and ...
 7-278 1.07e-133

S-formylglutathione hydrolase; This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well. [Cellular processes, Detoxification]


Pssm-ID: 131868  Cd Length: 275  Bit Score: 379.51  E-value: 1.07e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092   7 IARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQAEQGQkVPVLYWLSGLTCTDENFATKAGAQQFAAQHGIAIVMPDTS 86
Cdd:TIGR02821   3 ISSHACFGGTQGFYRHKSETCGVPMTFGVFLPPQAAAGP-VPVLWYLSGLTCTHENFMIKAGAQRFAAEHGLALVAPDTS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  87 PRGEAVAN-DEGYDLGQGAGFYLNATQQPWATHFKMYDYIVQELPALIEANFPVS-DKRSISGHSMGGHGAIQIGLKNPE 164
Cdd:TIGR02821  82 PRGTGIAGeDDAWDFGKGAGFYVDATEEPWSQHYRMYSYIVQELPALVAAQFPLDgERQGITGHSMGGHGALVIALKNPD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 165 RYCAISAFSPIVTPSQVPWGQKAFTAYLGENQTAWAEYDSFALLDNVSPARPILIEQGLADSFYPTQLQPEIFTEKAKKL 244
Cdd:TIGR02821 162 RFKSVSAFAPIVAPSRCPWGQKAFSAYLGADEAAWRSYDASLLVADGGRHSTILIDQGTADQFLDEQLRPDAFEQACRAA 241

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2494728092 245 GLDVTLNLHEGYDHSYFFIASFIEKHIVFHARAL 278
Cdd:TIGR02821 242 GQALTLRRQAGYDHSYYFIASFIADHLRHHAERL 275
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
14-278 1.95e-114

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 329.49  E-value: 1.95e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  14 GGYHERYTHYSNSTHCEMTFAIYLPPQAEqGQKVPVLYWLSGLTCTDENFATKAGAQQFAAQHGIAIVMPDtsprgeava 93
Cdd:COG0627     1 GGRVVRVTVPSPALGREMPVSVYLPPGYD-GRPLPVLYLLHGLTGTHENWTRKTGAQRLAAELGVIVVMPD--------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  94 ndegydlGQGAGFYLNATQQPwATHFKMYDYIVQELPALIEANFPVS---DKRSISGHSMGGHGAIQIGLKNPERYCAIS 170
Cdd:COG0627    71 -------GGQASFYVDWTQGP-AGHYRWETYLTEELPPLIEANFPVSadrERRAIAGLSMGGHGALTLALRHPDLFRAVA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 171 AFSPIVTPSQVPWGQKAFTAYLG-ENQTAWAEYDSFALLDNVSPARPILIEQGLADS-FYPTQLQpeiFTEKAKKLGLDV 248
Cdd:COG0627   143 AFSGILDPSQPPWGEKAFDAYFGpPDRAAWAANDPLALAEKLRAGLPLYIDCGTADPfFLEANRQ---LHAALRAAGIPH 219

                         250       260       270
                  ....*....|....*....|....*....|
gi 2494728092 249 TLNLHEGYdHSYFFIASFIEKHIVFHARAL 278
Cdd:COG0627   220 TYRERPGG-HSWYYWASFLEDHLPFLARAL 248
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 24-271 7.92e-69

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 213.48  E-value: 7.92e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  24 SNSTHCEMTFAIYLPPQAEQGQKVPVLYWLSGlTCTDENFATKAGAQQFAAQHGIAIVMPDTSPRGEAVANDEGYDLGqg 103
Cdd:pfam00756   1 SNSLGREMKVQVYLPEDYPPGRKYPVLYLLDG-TGWFQNGPAKEGLDRLAASGEIPPVIIVGSPRGGEVSFYSDWDRG-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 104 agfyLNATQQPWATHFKmyDYIVQELPALIEANFPV-SDKRSISGHSMGGHGAIQIGLKNPERYCAISAFSPIVTPSQVP 182
Cdd:pfam00756  78 ----LNATEGPGAYAYE--TFLTQELPPLLDANFPTaPDGRALAGQSMGGLGALYLALKYPDLFGSVSSFSPILNPSNSM 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 183 WGQkaftaylgENQTAWAEYDSFALLDNVSPARP---ILIEQGLADSFYPTQLQPEI--FTEKAKKLGLDVTLNLHEGYD 257
Cdd:pfam00756 152 WGP--------EDDPAWQEGDPVLLAVALSANNTrlrIYLDVGTREDFLGDQLPVEIleELAPNRELAEQLAYRGVGGYD 223

                         250       260
                  ....*....|....*....|.
gi 2494728092 258 HSY-------FFIASFIEKHI 271
Cdd:pfam00756 224 HEYygghdwaYWRAQLIAALI 244
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
18-260 4.72e-26

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 104.55  E-value: 4.72e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  18 ERYTHYSNSTHCEMTFAIYLPPQAEQ-GQKVPVLYWLSGLTCTDENFATKAGAQQFA----AQHGI---AIVMPDTSPRG 89
Cdd:COG2382    82 ETVTYPSKALGRTRRVWVYLPPGYDNpGKKYPVLYLLDGGGGDEQDWFDQGRLPTILdnliAAGKIppmIVVMPDGGDGG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  90 EAVANDEGYDlgqgagfylnatqqpwathfKMYDYIVQELPALIEANFPVSDKRS---ISGHSMGGHGAIQIGLKNPERY 166
Cdd:COG2382   162 DRGTEGPGND--------------------AFERFLAEELIPFVEKNYRVSADPEhraIAGLSMGGLAALYAALRHPDLF 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 167 CAISAFSPivtpsqvpwgqkaftaYLGENQTAWAEYDSFALLDNVSPARP--ILIEQGLADSFYPTQLQpeiFTEKAKKL 244
Cdd:COG2382   222 GYVGSFSG----------------SFWWPPGDADRGGWAELLAAGAPKKPlrFYLDVGTEDDLLEANRA---LAAALKAK 282

                         250
                  ....*....|....*.
gi 2494728092 245 GLDVTLNLHEGyDHSY 260
Cdd:COG2382   283 GYDVEYREFPG-GHDW 297
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
35-271 7.27e-12

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 63.50  E-value: 7.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  35 IYLPPQaeqGQKVPVLYWLSGLTCTDENfATKAGAQQFAaQHGIAIVMPDtsPRGEavandegydlGQGAGfylNATQQP 114
Cdd:COG1506    14 LYLPAD---GKKYPVVVYVHGGPGSRDD-SFLPLAQALA-SRGYAVLAPD--YRGY----------GESAG---DWGGDE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 115 WATHFKMYDYIVQElpalieanfPVSDKRSI--SGHSMGGHGAIQIGLKNPERYCAISAFSPIVTPSQVPWGQKAFTAYL 192
Cdd:COG1506    74 VDDVLAAIDYLAAR---------PYVDPDRIgiYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTREYTERL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 193 ----GENQTAWAEYDSFALLDNVSpaRPILIEQGLADSFYPTQlQPEIFTEKAKKLGLDVTLNLHEGYDHSYFF------ 262
Cdd:COG1506   145 mggpWEDPEAYAARSPLAYADKLK--TPLLLIHGEADDRVPPE-QAERLYEALKKAGKPVELLVYPGEGHGFSGagapdy 221

                         250
                  ....*....|..
gi 2494728092 263 ---IASFIEKHI 271
Cdd:COG1506   222 lerILDFLDRHL 233
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
35-174 1.98e-10

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 59.61  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  35 IYLPPQAEQG-QKVPVLYWLSGltctDENFATKAGAQQFAAQHG-----IAIV-----------MPDTSPRGEAVANDEG 97
Cdd:COG2819    25 VYLPPGYDAPeKRYPVLYMLDG----QNLFDALAGAVGTLSRLEggippAIVVgigngddgerrLRDYTPPPAPGYPGPG 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2494728092  98 YDLGQGAGFYlnatqqpwathfkmyDYIVQELPALIEANFPVS-DKRSISGHSMGGHGAIQIGLKNPERYCAISAFSP 174
Cdd:COG2819   101 GPGGGADAFL---------------RFLEEELKPYIDKRYRTDpERTGLIGHSLGGLFSLYALLKYPDLFGRYIAISP 163
COG4099 COG4099
Predicted peptidase [General function prediction only];
18-258 4.49e-09

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 55.74  E-value: 4.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  18 ERYTHYSNSThcEMTFAIYLPPQAEQGQKVPVLYWL--SGLTCTDENFATKAGAQQFA-----AQHGIAIVMPdTSPRGE 90
Cdd:COG4099    22 RTFTDPSDGD--TLPYRLYLPKGYDPGKKYPLVLFLhgAGERGTDNEKQLTHGAPKFInpenqAKFPAIVLAP-QCPEDD 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  91 AvandegydlgqgagfylnatqqpWathfkMYDYIVQELPALIE---ANFPV-SDKRSISGHSMGGHGAIQIGLKNPERY 166
Cdd:COG4099    99 Y-----------------------W-----SDTKALDAVLALLDdliAEYRIdPDRIYLTGLSMGGYGTWDLAARYPDLF 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 167 CAISAFSPIVTPSQVPWgqkaftaylgenqtawaeydsfalLDNVsparPILIEQGLADSFYPTQlQPEIFTEKAKKLGL 246
Cdd:COG4099   151 AAAVPICGGGDPANAAN------------------------LKKV----PVWIFHGAKDDVVPVE-ESRAMVEALKAAGA 201

                         250
                  ....*....|..
gi 2494728092 247 DVTLNLHEGYDH 258
Cdd:COG4099   202 DVKYTEYPGVGH 213
PRK10566 PRK10566
esterase; Provisional
 39-229 7.13e-05

esterase; Provisional


Pssm-ID: 182555 [Multi-domain]  Cd Length: 249  Bit Score: 43.05  E-value: 7.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  39 PQAEQGQKVPVLYWLSGLTCTDENFATKAGAqqfAAQHGIAIVMPDTsprgeavandegydLGQGAGFYLNATQQpwATH 118
Cdd:PRK10566   19 PAGQRDTPLPTVFFYHGFTSSKLVYSYFAVA---LAQAGFRVIMPDA--------------PMHGARFSGDEARR--LNH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 119 FkmYDYI---VQELPAL----IEANFPVSDKRSISGHSMGGHGAIQIGLKNPERYCAIS-------------AFSPIvtP 178
Cdd:PRK10566   80 F--WQILlqnMQEFPTLraaiREEGWLLDDRLAVGGASMGGMTALGIMARHPWVKCVASlmgsgyftslartLFPPL--I 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2494728092 179 SQVPWGQKAFTAYLgenqTAWAEYDSFALLDNVSpARPILIEQGLADSFYP 229
Cdd:PRK10566  156 PETAAQQAEFNNIV----APLAEWEVTHQLEQLA-DRPLLLWHGLADDVVP 201
Esterase_PHB pfam10503
Esterase PHB depolymerase; This family of proteins include acetyl xylan esterases (AXE), ...
 31-226 2.59e-03

Esterase PHB depolymerase; This family of proteins include acetyl xylan esterases (AXE), feruloyl esterases (FAE), and poly(3-hydroxybutyrate) (PHB) depolymerases.


Pssm-ID: 431322 [Multi-domain]  Cd Length: 222  Bit Score: 38.50  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  31 MTFAIYLPPQA-EQGQKVPVLYWLSGLTCTDENFATKAGAQQFAAQHGIAIVMPDTSPRGEAVANDEGYD-LGQGAGFYL 108
Cdd:pfam10503   1 LAYALYLPPEAaGDGAPMPLVVMLHGCKQHADDFAAGTRINALADELGFAVLYPEQSKHAHAHKCWNWFDeQGAARGGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 109 NATqqpwathfkmydyIVQELPALIEANFPVSDKRSISGHSMGGHGAIQIGLKNPerycaiSAFSPIVTPSQVPWGQKAF 188
Cdd:pfam10503  81 AAS-------------IAALAKAIAAAHRLDGARVYLAGLSAGAALAALLAHCYP------DVFAAVGLHSGLPFGCAAD 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2494728092 189 TAYLGENQTAWAEYDSFALLDNVS-----PARPILIEQGLADS 226
Cdd:pfam10503 142 AASALDAMRRGPGPAPGALIDAASdvrsyPALPAIIFHGDADS 184
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 122-193 5.30e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 37.58  E-value: 5.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2494728092 122 YDYIVQELPALIE---ANFPVSdKRSISGHSMGGHGAIQIGLKNPERYCAISAFSP--IVTPSQVPWGQKAFTAYLG 193
Cdd:pfam12146  55 FDDYVDDLDTFVDkirEEHPGL-PLFLLGHSMGGLIAALYALRYPDKVDGLILSAPalKIKPYLAPPILKLLAKLLG 130
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
70-271 8.98e-03

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 36.82  E-value: 8.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092  70 QQFAAQHGIAIVMPDtsPRGEAvandegydlGQGAGFYLNATQQPWATHFKmyDYI--VQelpALIEANFPVSDKRSISG 147
Cdd:pfam00326   7 AQLLADRGYVVAIAN--GRGSG---------GYGEAFHDAGKGDLGQNEFD--DFIaaAE---YLIEQGYTDPDRLAIWG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494728092 148 HSMGGHGAIQIGLKNPERY-CAISAfSPIVTP-SQVPWGQKAFTAYLGENQTAWAEYDSFALLDNVSPAR------PILI 219
Cdd:pfam00326  71 GSYGGYLTGAALNQRPDLFkAAVAH-VPVVDWlAYMSDTSLPFTERYMEWGNPWDNEEGYDYLSPYSPADnvkvypPLLL 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2494728092 220 EQGLADSFYPTQlQPEIFTEKAKKLGLDVTLNLHEGYDHS----------YFFIASFIEKHI 271
Cdd:pfam00326 150 IHGLLDDRVPPW-QSLKLVAALQRKGVPFLLLIFPDEGHGigkprnkveeYARELAFLLEYL 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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