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Conserved domains on  [gi|2503006532|ref|WP_282063943|]
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YihY/virulence factor BrkB family protein, partial [Roseobacter litoralis]

Protein Classification

YihY/virulence factor BrkB family protein( domain architecture ID 10003440)

YihY/virulence factor BrkB family protein similar to Bordetella pertussis BrkB, a virulence factor that is essential for resistance to complement-dependent killing by serum

Gene Ontology:  GO:0016020
PubMed:  8955422

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BrkB COG1295
Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase) [Function unknown];
1-91 1.25e-29

Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase) [Function unknown];


:

Pssm-ID: 440906  Cd Length: 289  Bit Score: 107.26  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503006532   1 AVLYRYAPSRDAAeWKWASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAEL 80
Cdd:COG1295   198 ALLYRFLPNRRVR-WRDALPGALLAALLWELASYLFSLYVSNFSSYNATYGSLGAVIILLLWLYLSALILLLGAELNAVL 276

                          90
                  ....*....|.
gi 2503006532  81 EAQTRVDTTQG 91
Cdd:COG1295   277 ERRRGLRAEPR 287
 
Name Accession Description Interval E-value
BrkB COG1295
Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase) [Function unknown];
1-91 1.25e-29

Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase) [Function unknown];


Pssm-ID: 440906  Cd Length: 289  Bit Score: 107.26  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503006532   1 AVLYRYAPSRDAAeWKWASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAEL 80
Cdd:COG1295   198 ALLYRFLPNRRVR-WRDALPGALLAALLWELASYLFSLYVSNFSSYNATYGSLGAVIILLLWLYLSALILLLGAELNAVL 276

                          90
                  ....*....|.
gi 2503006532  81 EAQTRVDTTQG 91
Cdd:COG1295   277 ERRRGLRAEPR 287
Virul_fac_BrkB pfam03631
Virulence factor BrkB; This family acts as a virulence factor. In Bordetella pertussis, Swiss: ...
 1-81 7.13e-24

Virulence factor BrkB; This family acts as a virulence factor. In Bordetella pertussis, Swiss:Q45339 is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.


Pssm-ID: 460996  Cd Length: 256  Bit Score: 91.54  E-value: 7.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503006532   1 AVLYRYAPSRdAAEWKWASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAEL 80
Cdd:pfam03631 174 ALLYRFLPNV-KVRWRAALPGALLAALLWELLKYGFSLYLSNFASYNAVYGSFGAVIILLLWLYLSWLIVLLGAELNAAL 252


                  .
gi 2503006532  81 E 81
Cdd:pfam03631 253 Q 253
yihY_not_rbn TIGR00765
YihY family inner membrane protein; Initial identification of members of this protein family ...
 3-82 1.10e-15

YihY family inner membrane protein; Initial identification of members of this protein family was based on characterization of the yihY gene product as ribonuclease BN in Escherichia coli. This identification has been withdrawn, as the group now finds the homolog in E. coli of RNase Z is the true ribonuclease BN rather than a strict functional equivalent of RNase Z. Members of this subfamily include the largely uncharacterized BrkB (Bordetella resist killing by serum B) from Bordetella pertussis. Some members have an additional C-terminal domain. Paralogs from E. coli (yhjD) and Mycobactrium tuberculosis (Rv3335c) are part of a smaller, related subfamily that form their own cluster. [Unknown function, General]


Pssm-ID: 273260  Cd Length: 259  Bit Score: 70.09  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503006532   3 LYRYAPSRdAAEWKWASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAELEA 82
Cdd:TIGR00765 180 LYTIVPNK-KVKHRHAFVGAFFAAVLFELAKWLFTFYVSTFATYQLIYGALAVLPFLMLWVYLSWLVVLLGAEITSSLDY 258
rbn PRK04214
ribonuclease BN/unknown domain fusion protein; Reviewed
 1-82 2.17e-11

ribonuclease BN/unknown domain fusion protein; Reviewed


Pssm-ID: 179791 [Multi-domain]  Cd Length: 412  Bit Score: 58.99  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503006532   1 AVLYRYAPSRdAAEWKWASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAEL 80
Cdd:PRK04214  195 TLLYRVVPNH-FVPLRHALPGALLTAVLLELVKWGFGFYLGNFQTYQRIYGAFAAVPILLLWIYLLWVLVLLGASLTSSL 273


                  ..
gi 2503006532  81 EA 82
Cdd:PRK04214  274 SY 275
 
Name Accession Description Interval E-value
BrkB COG1295
Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase) [Function unknown];
1-91 1.25e-29

Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase) [Function unknown];


Pssm-ID: 440906  Cd Length: 289  Bit Score: 107.26  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503006532   1 AVLYRYAPSRDAAeWKWASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAEL 80
Cdd:COG1295   198 ALLYRFLPNRRVR-WRDALPGALLAALLWELASYLFSLYVSNFSSYNATYGSLGAVIILLLWLYLSALILLLGAELNAVL 276

                          90
                  ....*....|.
gi 2503006532  81 EAQTRVDTTQG 91
Cdd:COG1295   277 ERRRGLRAEPR 287
Virul_fac_BrkB pfam03631
Virulence factor BrkB; This family acts as a virulence factor. In Bordetella pertussis, Swiss: ...
 1-81 7.13e-24

Virulence factor BrkB; This family acts as a virulence factor. In Bordetella pertussis, Swiss:Q45339 is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.


Pssm-ID: 460996  Cd Length: 256  Bit Score: 91.54  E-value: 7.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503006532   1 AVLYRYAPSRdAAEWKWASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAEL 80
Cdd:pfam03631 174 ALLYRFLPNV-KVRWRAALPGALLAALLWELLKYGFSLYLSNFASYNAVYGSFGAVIILLLWLYLSWLIVLLGAELNAAL 252


                  .
gi 2503006532  81 E 81
Cdd:pfam03631 253 Q 253
yihY_not_rbn TIGR00765
YihY family inner membrane protein; Initial identification of members of this protein family ...
 3-82 1.10e-15

YihY family inner membrane protein; Initial identification of members of this protein family was based on characterization of the yihY gene product as ribonuclease BN in Escherichia coli. This identification has been withdrawn, as the group now finds the homolog in E. coli of RNase Z is the true ribonuclease BN rather than a strict functional equivalent of RNase Z. Members of this subfamily include the largely uncharacterized BrkB (Bordetella resist killing by serum B) from Bordetella pertussis. Some members have an additional C-terminal domain. Paralogs from E. coli (yhjD) and Mycobactrium tuberculosis (Rv3335c) are part of a smaller, related subfamily that form their own cluster. [Unknown function, General]


Pssm-ID: 273260  Cd Length: 259  Bit Score: 70.09  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503006532   3 LYRYAPSRdAAEWKWASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAELEA 82
Cdd:TIGR00765 180 LYTIVPNK-KVKHRHAFVGAFFAAVLFELAKWLFTFYVSTFATYQLIYGALAVLPFLMLWVYLSWLVVLLGAEITSSLDY 258
rbn PRK04214
ribonuclease BN/unknown domain fusion protein; Reviewed
 1-82 2.17e-11

ribonuclease BN/unknown domain fusion protein; Reviewed


Pssm-ID: 179791 [Multi-domain]  Cd Length: 412  Bit Score: 58.99  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503006532   1 AVLYRYAPSRdAAEWKWASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAEL 80
Cdd:PRK04214  195 TLLYRVVPNH-FVPLRHALPGALLTAVLLELVKWGFGFYLGNFQTYQRIYGAFAAVPILLLWIYLLWVLVLLGASLTSSL 273


                  ..
gi 2503006532  81 EA 82
Cdd:PRK04214  274 SY 275
PRK01637 PRK01637
virulence factor BrkB family protein;
18-81 2.51e-10

virulence factor BrkB family protein;


Pssm-ID: 179313  Cd Length: 286  Bit Score: 55.68  E-value: 2.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2503006532  18 ASVGAVVGCLMWIVASAGFAFYVSNFGSYNESFGTLAGVIVLLMWFWISAFIILLGAELNAELE 81
Cdd:PRK01637  204 ALVGALVAALLFELGKKGFALYITTFPSYQLIYGALAVIPILFVWVYLSWCIVLLGAEITATLG 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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