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Conserved domains on  [gi|2519615232|ref|WP_285139533|]
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MULTISPECIES: efflux RND transporter periplasmic adaptor subunit [Sphingomonas]

Protein Classification

efflux RND transporter periplasmic adaptor subunit( domain architecture ID 1001665)

efflux RND transporter periplasmic adaptor subunit similar to Escherichia coli Multidrug export protein AcrE, part of the tripartite efflux system AcrEF-TolC, which is involved in the efflux of indole and organic solvents

CATH:  1.20.1600.10
Gene Ontology:  GO:0022857|GO:0055085
SCOP:  4003096
TCDB:  8.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK15030 super family cl33066
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
1-375 1.51e-102

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


The actual alignment was detected with superfamily member PRK15030:

Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 309.34  E-value: 1.51e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232   1 MSSNR---LMGRVLASAAVLALTACGAGGKQQQQQAAQGpapVSYVVASEQPVTLTTELPGRTTAFETSDVRPQVNGLIT 77
Cdd:PRK15030    1 MNKNRgftPLAVVLMLSGSLALTGCDDKQAQQGGQQMPA---VGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIIL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  78 QRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAALARRYGELVKINAIARQEFENAQTSAAQARADV 157
Cdd:PRK15030   78 KRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 158 AAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTDALATIQRLDPIYVDIQEPSAELLKLRRQIMSGQLTR 237
Cdd:PRK15030  158 TAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 238 D-GNARVRLKLEDGSDYGPQGTLRFADVTVDPTTGSQVIRALFPNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDE 316
Cdd:PRK15030  238 EnGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTP 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2519615232 317 KGQATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKIIVEGGMMLRPGMPVQGK 375
Cdd:PRK15030  318 RGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQ 376
 
Name Accession Description Interval E-value
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
1-375 1.51e-102

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 309.34  E-value: 1.51e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232   1 MSSNR---LMGRVLASAAVLALTACGAGGKQQQQQAAQGpapVSYVVASEQPVTLTTELPGRTTAFETSDVRPQVNGLIT 77
Cdd:PRK15030    1 MNKNRgftPLAVVLMLSGSLALTGCDDKQAQQGGQQMPA---VGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIIL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  78 QRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAALARRYGELVKINAIARQEFENAQTSAAQARADV 157
Cdd:PRK15030   78 KRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 158 AAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTDALATIQRLDPIYVDIQEPSAELLKLRRQIMSGQLTR 237
Cdd:PRK15030  158 TAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 238 D-GNARVRLKLEDGSDYGPQGTLRFADVTVDPTTGSQVIRALFPNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDE 316
Cdd:PRK15030  238 EnGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTP 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2519615232 317 KGQATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKIIVEGGMMLRPGMPVQGK 375
Cdd:PRK15030  318 RGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQ 376
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 45-379 3.71e-93

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 282.60  E-value: 3.71e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  45 ASEQPVTLTTELPGRTTAFETSDVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAA 124
Cdd:COG0845     3 VERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAKA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 125 LARRYGELVKINAIARQEFENAQTSAAQARADVAAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQtdALA 204
Cdd:COG0845    83 ELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 205 TIQRLDPIYVDIQEPSAELLKLRRqimsgqltrdgNARVRLKLEDGSDYGPQGTLRFADVTVDPTTGSQVIRALFPNPNG 284
Cdd:COG0845   161 TIADLDPLEVEFDVPESDLARLKV-----------GQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 285 LLLPGMFARASLVEGTQSNAFLVPQRAVSRDEkGQATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKIIVEGGM 364
Cdd:COG0845   230 LLRPGMFVRVRIVLGERENALLVPASAVVRDG-GGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQ 308

                         330
                  ....*....|....*
gi 2519615232 365 MLRPGMPVQGKPWNP 379
Cdd:COG0845   309 RLRDGAKVRVVEAAA 323
RND-peri-MexC NF033138
MexC family multidrug efflux RND transporter periplasmic adaptor subunit;
1-376 3.28e-92

MexC family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 411094  Cd Length: 375  Bit Score: 282.02  E-value: 3.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232   1 MSSNRLMGRVLASAAVLALTACGAGGKQQQQQAAQGPAPVSYVVAseQPVTLTTELPGRTTAFETSDVRPQVNGLITQRL 80
Cdd:NF033138    1 MGNLRAIGMAGALAAAIALAGCGPAEEQQAAAEVARPVEVVAVAT--EPLALTSELPGRVEPMRVAEVRARVAGIVLQKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  81 FVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAALARRYGELVKINAIARQEFENAQTSAAQARADVAAQ 160
Cdd:NF033138   79 FEEGADVKAGDLLFQIDPAPLKAALSRAEGELARAQAVLLEAQARVKRYEPLVKIEAVSQQDFDTATADLRSAQAATRSA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 161 QAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTDALATIQRLDPIYVDIQEPSAELLKLRRQIMSGQLTRDGN 240
Cdd:NF033138  159 QADLETARLNLGYASVTAPISGRIGRALVTEGALVGQGDATLMARIQQLDPIYVDFTQSAADALRLREALKDGALAAGDS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 241 ARVRLKLEdGSDYGPQGTLRFADVTVDPTTGSQVIRALFPNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDEKGQA 320
Cdd:NF033138  239 QALSIRVE-GTDYERQGALMFTDVAVDRGTGQVSLRGKFDNADGVLLPGMYVRVRTPQGTDNQAILVPQRAVQRGSDGSA 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2519615232 321 TVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKIIVEGGMMLRPGMPVQGKP 376
Cdd:NF033138  318 QVMVVGADGRAEARSVRTGAMQGSRWQISEGLKAGDQVIVGGLAGLQPGAKVVPKQ 373
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 40-373 3.75e-79

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 246.46  E-value: 3.75e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  40 VSYVVASEQPVTLTTELPGRTTAFETSDVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASI 119
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 120 ASSAALARRYGELVKINAIARQEFENAQTSAAQARADVAAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQ 199
Cdd:TIGR01730  81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 200 TdaLATIQRLDPIYVDIQEPSAELlklrrqimsGQLTRDGNARVRLKLEDGSDYgpQGTLRFADVTVDPTTGSQVIRALF 279
Cdd:TIGR01730 161 T--LATIVDLDPLEADFSVPERDL---------PQLRRGQTLTVELDALPGEEF--KGKLRFIDPRVDSGTGTVRVRATF 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 280 PNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDEKGqATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKII 359
Cdd:TIGR01730 228 PNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNG-KYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIV 306

                         330
                  ....*....|....
gi 2519615232 360 VEGGMMLRPGMPVQ 373
Cdd:TIGR01730 307 TAGVVKLRDGAKVK 320
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 47-360 1.42e-63

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 206.51  E-value: 1.42e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  47 EQPVTLTTELPGRTTAFETSD-VRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAAL 125
Cdd:pfam00529   1 LAPLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 126 ARRYGELVKINAIARQEFENAQTSAAQARADVAAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTDALAT 205
Cdd:pfam00529  81 LDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLAT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 206 IQRLDPIYVDIQEPSAELLKLRRQIMSGQLTRDGNARVRLKL--EDGSDY---GPQ-GTLRFADVTVDPTTGSQVIRALF 279
Cdd:pfam00529 161 VAQLDQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAELKLakLDLERTeirAPVdGTVAFLSVTVDGGTVSAGLRLMF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 280 PNP-NGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDEKGQATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKI 358
Cdd:pfam00529 241 VVPeDNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALV 320


                  ..
gi 2519615232 359 IV 360
Cdd:pfam00529 321 RL 322
 
Name Accession Description Interval E-value
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
1-375 1.51e-102

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 309.34  E-value: 1.51e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232   1 MSSNR---LMGRVLASAAVLALTACGAGGKQQQQQAAQGpapVSYVVASEQPVTLTTELPGRTTAFETSDVRPQVNGLIT 77
Cdd:PRK15030    1 MNKNRgftPLAVVLMLSGSLALTGCDDKQAQQGGQQMPA---VGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIIL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  78 QRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAALARRYGELVKINAIARQEFENAQTSAAQARADV 157
Cdd:PRK15030   78 KRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 158 AAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTDALATIQRLDPIYVDIQEPSAELLKLRRQIMSGQLTR 237
Cdd:PRK15030  158 TAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 238 D-GNARVRLKLEDGSDYGPQGTLRFADVTVDPTTGSQVIRALFPNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDE 316
Cdd:PRK15030  238 EnGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTP 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2519615232 317 KGQATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKIIVEGGMMLRPGMPVQGK 375
Cdd:PRK15030  318 RGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQ 376
PRK09859 PRK09859
multidrug transporter subunit MdtE;
40-374 1.50e-99

multidrug transporter subunit MdtE;


Pssm-ID: 137559 [Multi-domain]  Cd Length: 385  Bit Score: 301.25  E-value: 1.50e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  40 VSYVVASEQPVTLTTELPGRTTAFETSDVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASI 119
Cdd:PRK09859   36 VGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 120 ASSAALARRYGELVKINAIARQEFENAQTSAAQARADVAAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQ 199
Cdd:PRK09859  116 SNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQ 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 200 TDALATIQRLDPIYVDIQEPSAELLKLRRQIMSGQLTR-DGNARVRLKLEDGSDYGPQGTLRFADVTVDPTTGSQVIRAL 278
Cdd:PRK09859  196 ADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQvQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAI 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 279 FPNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDEKGQATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKI 358
Cdd:PRK09859  276 FPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRV 355

                         330
                  ....*....|....*.
gi 2519615232 359 IVEGGMMLRPGMPVQG 374
Cdd:PRK09859  356 IVSGLQRIRPGIKARA 371
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 45-379 3.71e-93

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 282.60  E-value: 3.71e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  45 ASEQPVTLTTELPGRTTAFETSDVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAA 124
Cdd:COG0845     3 VERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAKA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 125 LARRYGELVKINAIARQEFENAQTSAAQARADVAAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQtdALA 204
Cdd:COG0845    83 ELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 205 TIQRLDPIYVDIQEPSAELLKLRRqimsgqltrdgNARVRLKLEDGSDYGPQGTLRFADVTVDPTTGSQVIRALFPNPNG 284
Cdd:COG0845   161 TIADLDPLEVEFDVPESDLARLKV-----------GQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 285 LLLPGMFARASLVEGTQSNAFLVPQRAVSRDEkGQATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKIIVEGGM 364
Cdd:COG0845   230 LLRPGMFVRVRIVLGERENALLVPASAVVRDG-GGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQ 308

                         330
                  ....*....|....*
gi 2519615232 365 MLRPGMPVQGKPWNP 379
Cdd:COG0845   309 RLRDGAKVRVVEAAA 323
RND-peri-MexC NF033138
MexC family multidrug efflux RND transporter periplasmic adaptor subunit;
1-376 3.28e-92

MexC family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 411094  Cd Length: 375  Bit Score: 282.02  E-value: 3.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232   1 MSSNRLMGRVLASAAVLALTACGAGGKQQQQQAAQGPAPVSYVVAseQPVTLTTELPGRTTAFETSDVRPQVNGLITQRL 80
Cdd:NF033138    1 MGNLRAIGMAGALAAAIALAGCGPAEEQQAAAEVARPVEVVAVAT--EPLALTSELPGRVEPMRVAEVRARVAGIVLQKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  81 FVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAALARRYGELVKINAIARQEFENAQTSAAQARADVAAQ 160
Cdd:NF033138   79 FEEGADVKAGDLLFQIDPAPLKAALSRAEGELARAQAVLLEAQARVKRYEPLVKIEAVSQQDFDTATADLRSAQAATRSA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 161 QAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTDALATIQRLDPIYVDIQEPSAELLKLRRQIMSGQLTRDGN 240
Cdd:NF033138  159 QADLETARLNLGYASVTAPISGRIGRALVTEGALVGQGDATLMARIQQLDPIYVDFTQSAADALRLREALKDGALAAGDS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 241 ARVRLKLEdGSDYGPQGTLRFADVTVDPTTGSQVIRALFPNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDEKGQA 320
Cdd:NF033138  239 QALSIRVE-GTDYERQGALMFTDVAVDRGTGQVSLRGKFDNADGVLLPGMYVRVRTPQGTDNQAILVPQRAVQRGSDGSA 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2519615232 321 TVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKIIVEGGMMLRPGMPVQGKP 376
Cdd:NF033138  318 QVMVVGADGRAEARSVRTGAMQGSRWQISEGLKAGDQVIVGGLAGLQPGAKVVPKQ 373
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 40-373 3.75e-79

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 246.46  E-value: 3.75e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  40 VSYVVASEQPVTLTTELPGRTTAFETSDVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASI 119
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 120 ASSAALARRYGELVKINAIARQEFENAQTSAAQARADVAAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQ 199
Cdd:TIGR01730  81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 200 TdaLATIQRLDPIYVDIQEPSAELlklrrqimsGQLTRDGNARVRLKLEDGSDYgpQGTLRFADVTVDPTTGSQVIRALF 279
Cdd:TIGR01730 161 T--LATIVDLDPLEADFSVPERDL---------PQLRRGQTLTVELDALPGEEF--KGKLRFIDPRVDSGTGTVRVRATF 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 280 PNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDEKGqATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKII 359
Cdd:TIGR01730 228 PNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNG-KYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIV 306

                         330
                  ....*....|....
gi 2519615232 360 VEGGMMLRPGMPVQ 373
Cdd:TIGR01730 307 TAGVVKLRDGAKVK 320
PRK09578 PRK09578
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
3-373 1.20e-77

MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 169982 [Multi-domain]  Cd Length: 385  Bit Score: 244.70  E-value: 1.20e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232   3 SNRLMGRVLASAAVLALTACGAGGKQQQQQAAQGpapVSYVVASEQPVTLTTELPGRTTAFETSDVRPQVNGLITQRLFV 82
Cdd:PRK09578    4 ARRRRLLLAALVALFVLAGCGKGDSDAAAAAPRE---ATVVTVRPTSVPMTVELPGRLDAYRQAEVRARVAGIVTARTYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  83 EGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAALARRYGELVKINAIARQEFENAQTSAAQARADVAAQQA 162
Cdd:PRK09578   81 EGQEVKQGAVLFRIDPAPLKAARDAAAGALAKAEAAHLAALDKRRRYDDLVRDRAVSERDYTEAVADERQAKAAVASAKA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 163 ALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTDALATIQRLDPIYVDIQEPSAELLKLRRQIMSGQLT--RDGN 240
Cdd:PRK09578  161 ELARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVEALRRAVKSGRATgiAQQD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 241 ARVRLKLEDGSDYGPQGTLRFADVTVDPTTGSQVIRALFPNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSRdEKGQA 320
Cdd:PRK09578  241 VAVTLVRADGSEYPLKGKLLFSDLAVDPTTDTVAMRALFPNPERELLPGAYVRIALDRAVNPRAILVPRDALLR-TADSA 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2519615232 321 TVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKIIVEGGMMLRPGMPVQ 373
Cdd:PRK09578  320 SVKVVGQNGKVRDVEVEADQMSGRDWIVTRGLAGGERVIVDNAAQFAPGTAVK 372
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 47-360 1.42e-63

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 206.51  E-value: 1.42e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  47 EQPVTLTTELPGRTTAFETSD-VRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAAL 125
Cdd:pfam00529   1 LAPLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 126 ARRYGELVKINAIARQEFENAQTSAAQARADVAAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTDALAT 205
Cdd:pfam00529  81 LDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLAT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 206 IQRLDPIYVDIQEPSAELLKLRRQIMSGQLTRDGNARVRLKL--EDGSDY---GPQ-GTLRFADVTVDPTTGSQVIRALF 279
Cdd:pfam00529 161 VAQLDQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAELKLakLDLERTeirAPVdGTVAFLSVTVDGGTVSAGLRLMF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 280 PNP-NGLLLPGMFARASLVEGTQSNAFLVPQRAVSRDEKGQATVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKI 358
Cdd:pfam00529 241 VVPeDNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALV 320


                  ..
gi 2519615232 359 IV 360
Cdd:pfam00529 321 RL 322
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
58-373 1.30e-31

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 124.13  E-value: 1.30e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  58 GRTTAFETSDVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAALARRYGELVKINA 137
Cdd:PRK11556   80 GTVTAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKDQATLANARRDLARYQQLAKTNL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 138 IARQEFENAQTSAAQARADVAAQQAALRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTDALATIQRLDPIYVDIQ 217
Cdd:PRK11556  160 VSRQELDAQQALVSETEGTIKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFT 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 218 EPSAELlklrRQIMSGQLTrdgNARVRLKLEDGSDYG--PQGTLRFADVTVDPTTGSQVIRALFPNPNGLLLPGMFARAS 295
Cdd:PRK11556  240 LPESDI----ATVVQAQKA---GKPLVVEAWDRTNSKklSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNAR 312

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2519615232 296 LVEGTQSNAFLVPQRAVSRDEKGQaTVMVIGAGNKVEGRTLQTGRSVGDNWIVTSGLKAGDKIIVEGGMMLRPGMPVQ 373
Cdd:PRK11556  313 MLVDTLQNAVVIPTAALQMGNEGH-FVWVLNDENKVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVE 389
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
45-296 1.94e-19

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 88.18  E-value: 1.94e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  45 ASEQPVTLTTELPGRTTafetsDVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAA 124
Cdd:COG1566    30 GPDEPVTADGRVEARVV-----TVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQAEAQLAAAEAQLARLEA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 125 LA---------------------------RRYGELVKINAIARQEFENAQTSAAQARADVAAQQAA-------------- 163
Cdd:COG1566   105 ELgaeaeiaaaeaqlaaaqaqldlaqrelERYQALYKKGAVSQQELDEARAALDAAQAQLEAAQAQlaqaqaglreeeel 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 164 -------------LRTAQIDLARTTIRAPITGRIGRSVFTTGALVSASQTdaLATIQRLDPIYVDIQEPSAELLKLRRqi 230
Cdd:COG1566   185 aaaqaqvaqaeaaLAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQP--LLTIVPLDDLWVEAYVPETDLGRVKP-- 260

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2519615232 231 msGQltrdgnaRVRLKLEDGSDYGPQGTLRF------ADVTVDPTTGSQV----IRALFPNPNGLLL-PGMFARASL 296
Cdd:COG1566   261 --GQ-------PVEVRVDAYPDRVFEGKVTSispgagFTSPPKNATGNVVqrypVRIRLDNPDPEPLrPGMSATVEI 328
HlyD_D23 pfam16576
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ...
 49-292 7.06e-11

Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.


Pssm-ID: 435440 [Multi-domain]  Cd Length: 214  Bit Score: 61.37  E-value: 7.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  49 PVTLTTELPGRTTAFET--SDVRPQVNGLItQRLFV--EGDMVRQGQPLYHIdpapYQAQVASARAALTRAQASIASSAA 124
Cdd:pfam16576   1 PLSRTIRAVGRVAYDERrlAHVHARVEGWI-EKLYVnaTGDPVKKGQPLAEL----YSPELVAAQQEYLLALRSGDALSK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 125 LARRYGelvkinaiARQEFENAQTSAaqaradvaaqqaalrtAQID-LART-------TIRAPITGRIGRSVFTTGALVS 196
Cdd:pfam16576  76 SELLRA--------ARQRLRLLGMPE----------------AQIAeLERTgkvqptvTVYAPISGVVTELNVREGMYVQ 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 197 ASQTdaLATIQRLDPIYVDIQEPSAELlklrRQIMSGQltrdgNARVRLkledgsDYGP----QGTLRFADVTVDPTTGS 272
Cdd:pfam16576 132 PGDT--LFTIADLSTVWVEADVPEQDL----ALVKVGQ-----PAEVTL------PALPgktfEGKVDYIYPTLDPKTRT 194

                         250       260
                  ....*....|....*....|
gi 2519615232 273 QVIRALFPNPNGLLLPGMFA 292
Cdd:pfam16576 195 VRVRIELPNPDGRLKPGMFA 214
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
 47-360 1.61e-10

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 62.10  E-value: 1.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  47 EQPVTLTtelpGRTTAFETSDVRPQVNGLItQRLFVE-GDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAAL 125
Cdd:PRK11578   47 QQSVLAT----GKLDALRKVDVGAQVSGQL-KTLSVAiGDKVKKDQLLGVIDPEQAENQIKEVEATLMELRAQRQQAEAE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 126 AR-------RYGELVKINAIARQEFENAQTSAAQARADVAA-------QQAALRTAQIDLARTTIRAPITGRIGRSVFTT 191
Cdd:PRK11578  122 LKlarvtlsRQQRLAKTQAVSQQDLDTAATELAVKQAQIGTidaqikrNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQ 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 192 GALV-SASQTDALATIQRLDPIYVDIQEPSAELLKLRR-QIMSGQLTRDGNARVRLKLEDgsdygpqgtlrfadvtVDPT 269
Cdd:PRK11578  202 GQTViAAQQAPNILTLADMSTMLVKAQVSEADVIHLKPgQKAWFTVLGDPLTRYEGVLKD----------------ILPT 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 270 TgSQVIRALF-------PNPNGLLLPGMFARASLVEGTQSNAFLVPQRAVSR---DEKGQATVMVigaGNKVEGRTLQTG 339
Cdd:PRK11578  266 P-EKVNDAIFyyarfevPNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDpvgDNRYKVKLLR---NGETREREVTIG 341

                         330       340
                  ....*....|....*....|.
gi 2519615232 340 RSVGDNWIVTSGLKAGDKIIV 360
Cdd:PRK11578  342 ARNDTDVEIVKGLEAGDEVII 362
PRK09783 PRK09783
copper/silver efflux system membrane fusion protein CusB; Provisional
 164-362 7.31e-09

copper/silver efflux system membrane fusion protein CusB; Provisional


Pssm-ID: 236625 [Multi-domain]  Cd Length: 409  Bit Score: 57.18  E-value: 7.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 164 LRTAQIDLARTTIRAPITGRIgrSVFTTGALVSASQTDALATIQRLDPIYVD--IQEPSAELLKlrrqiMSGQLTRDGNA 241
Cdd:PRK09783  200 LIATRKIQTRFTLKAPIDGVI--TAFDLRAGMNIAKDNVVAKIQGMDPVWVTaaIPESIAWLVK-----DASQFTLTVPA 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 242 RvrlkledgsdygPQGTLRFADVT----VDPTTGSQVIRALFPNPNGLLLPGMFARASLveGTQSNA-FLVPQRAVSRDE 316
Cdd:PRK09783  273 R------------PDKTFTIRKWTllpsVDAATRTLQLRLEVDNADEALKPGMNAWLQL--NTASEPmLLIPSQALIDTG 338

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2519615232 317 KGQATVMVIGAGNKVEGRTLQTGRSVGDNWIvTSGLKAGDKIIVEG 362
Cdd:PRK09783  339 SEQRVITVDADGRFVPKRVAVFQESQGVTAI-RSGLAEGEKVVSSG 383
PRK10559 PRK10559
p-hydroxybenzoic acid efflux pump subunit AaeA;
54-182 6.20e-08

p-hydroxybenzoic acid efflux pump subunit AaeA;


Pssm-ID: 182548 [Multi-domain]  Cd Length: 310  Bit Score: 53.59  E-value: 6.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  54 TELPGRTTAFETSDV---RPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALTRAQASIASSAALARRYG 130
Cdd:PRK10559   33 TESPWTRDARFSADVvaiAPDVSGLITQVNVHDNQLVKKGQVLFTIDQPRYQKALAEAEADVAYYQVLAQEKRREAGRRN 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2519615232 131 ELvKINAIARQEFENAQTSAAQARADVAAQQAALRTAQIDLARTTIRAPITG 182
Cdd:PRK10559  113 RL-GVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADG 163
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
64-113 4.00e-07

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 46.28  E-value: 4.00e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2519615232  64 ETSDVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAALT 113
Cdd:pfam13533   1 PVVKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEAQLA 50
PRK10476 PRK10476
multidrug transporter subunit MdtN;
64-200 4.93e-06

multidrug transporter subunit MdtN;


Pssm-ID: 182488 [Multi-domain]  Cd Length: 346  Bit Score: 48.10  E-value: 4.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  64 ETSDVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAAL----------------------------TRA 115
Cdd:PRK10476   47 DVVHVASEVGGRIVELAVTENQAVKKGDLLFRIDPRPYELTVAQAQADLaladaqimttqrsvdaersnaasaneqvERA 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 116 QASIASSAALARRYGELVKINAIARQEFENAQT-------------------SAAQARADVAAQQAALRTAQIDLAR--- 173
Cdd:PRK10476  127 RANAKLATRTLERLEPLLAKGYVSAQQVDQARTaqrdaevslnqallqaqaaAAAVGGVDALVAQRAAREAALAIAElhl 206

                         170       180
                  ....*....|....*....|....*....
gi 2519615232 174 --TTIRAPITGRIGRSVFTTGALVSASQT 200
Cdd:PRK10476  207 edTTVRAPFDGRVVGLKVSVGEFAAPMQP 235
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
 175-289 2.66e-05

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 42.73  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 175 TIRAPITGRIGRSVFTTGALVSASQTdaLATIQRLDPIYVDIQEPSAELLKLRRQimsgqltrdgnARVRLKLEDGSDYG 254
Cdd:pfam13437   1 TIRAPVDGVVAELNVEEGQVVQAGDP--LATIVPPDRLLVEAFVPAADLGSLKKG-----------QKVTLKLDPGSDYT 67

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2519615232 255 PQGTLRFADVTVDPTTGSQVIRALFPNPNG--LLLPG 289
Cdd:pfam13437  68 LEGKVVRISPTVDPDTGVIPVRVSIENPKTpiPLLPG 104
PRK03598 PRK03598
putative efflux pump membrane fusion protein; Provisional
 72-200 7.70e-04

putative efflux pump membrane fusion protein; Provisional


Pssm-ID: 235136 [Multi-domain]  Cd Length: 331  Bit Score: 41.10  E-value: 7.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232  72 VNGLITQRLFVEGDMVRQGQPLYHIDPAPY-------QAQVAS-------------------ARAALTRAQASIASSAAL 125
Cdd:PRK03598   50 VGGRLASLAVDEGDAVKAGQVLGELDAAPYenalmqaKANVSVaqaqldlmlagyrdeeiaqARAAVKQAQAAYDYAQNF 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519615232 126 ARRYGELVKINAIARQEFENAQTSAAQARADV--------------------------AAQQAALRTAQIDLARTTIRAP 179
Cdd:PRK03598  130 YNRQQGLWKSRTISANDLENARSSRDQAQATLksaqdklsqyregnrpqdiaqakaslAQAQAALAQAELNLQDTELIAP 209

                         170       180
                  ....*....|....*....|.
gi 2519615232 180 ITGRIGRSVFTTGALVSASQT 200
Cdd:PRK03598  210 SDGTILTRAVEPGTMLNAGST 230
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 67-111 7.05e-03

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 38.51  E-value: 7.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2519615232  67 DVRPQVNGLITQRLFVEGDMVRQGQPLYHIDPAPYQAQVASARAA 111
Cdd:PTZ00144   89 DIRAPASGVITKIFAEEGDTVEVGAPLSEIDTGGAPPAAAPAAAA 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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