|
Name |
Accession |
Description |
Interval |
E-value |
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-386 |
2.61e-70 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 226.30 E-value: 2.61e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 13 KGQLFNLLLITFASTVGFWAWTIVGPLAKYYAkpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLA 92
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLA--EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 93 VSTPLVLLVGLAGSmksFPLMLVFSFLLGI-AGTVFAVGIPFSAAWYPPARKGFATGVF-GAGMVGTALSAFFTPRLMNL 170
Cdd:COG2223 79 LLGIGLLLLALAVS---YWLLLLLGLLLGIgGGGSFAVGIALVSKWFPPDRRGLALGLAaGGGNLGAAVAAFLAPLLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 171 VGYMNTHYIIAALCAVTAIISFLFLRDSPATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNI 250
Cdd:COG2223 156 FGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 251 YNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGS 330
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2519732639 331 VFGWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAAHrNYFIGLTLLAV 386
Cdd:COG2223 316 VFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-SYTAAFLVFAV 370
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
19-387 |
6.10e-65 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 212.11 E-value: 6.10e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFWAWTIVGPLAKYYAKPeqMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLV 98
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDD--LGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 99 LLVGLAGSmkSFPLMLVFSFLLGIAGTVFAVGIPFSAAWYPPARKG-FATGVFGAGMVGTALSAFFTPRLMNL------- 170
Cdd:cd17341 79 LALALAVS--SYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGgAAGGIAGAGNMGVAVSQLLAPLIAGAivfdggf 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 171 VGYMNTHYIIAALCAVTAIISFLFLRDSPaTANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNI 250
Cdd:cd17341 157 VGWRNAFFVPGILLAIAAVLVLLFGDDLP-TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 251 YNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGS 330
Cdd:cd17341 236 FGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGA 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 331 VFGWVGR---AADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAAHRnYFIGLTLLAVT 387
Cdd:cd17341 316 GNGSVFRmvpFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGS-GVGAFSLFGVL 374
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
18-359 |
1.43e-40 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 147.45 E-value: 1.43e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 18 NLLLITFASTVGFWAWTIVGPLAKYYAKPEqMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPL 97
Cdd:TIGR00886 2 NLFFSWFGFFLSFLVWFAFSPLAVFLIKDD-LGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 98 VLLVGLAGSmkSFPLMLVFSFLLGIAGTVFAVGIPFSAAWYPPARKGFATGVF-GAGMVGTALSAFFTPRLMNLVGYM-- 174
Cdd:TIGR00886 81 CLWAGLAVQ--SYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAaGWGNMGGGVAQFVMPPIIGSLIFGgg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 175 ---------NTHYIIAALCAVTAIISFLFLRDSPATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPT 245
Cdd:TIGR00886 159 qpahlawgwAFVIVPAGILLLPALLIFFVGADTPPGKPATGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 246 YLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFG-PKIITFIALGGVSALALVTAFQPDAEHVYGPIFLTMAA-- 322
Cdd:TIGR00886 239 LFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGgARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALff 318
|
330 340 350
....*....|....*....|....*....|....*..
gi 2519732639 323 LLGLGSGSVFGWVGRaADPKNVGAVSGVIAAAGALGG 359
Cdd:TIGR00886 319 FAGAGNGSTFALVPH-IFRRATGAVSGLIGAIGNLGG 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-359 |
1.41e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 103.52 E-value: 1.41e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 12 KKGQLFNLLLITFASTVGFWAWTIVGPLAKYYAkpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVL 91
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIA--ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 92 AVSTPLVLLVGLAGSmksFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFATGVFGAGM-VGTALSAFFTPRLMN 169
Cdd:COG2814 83 LLFALGSLLCALAPS---LWLLLAARFLQGLGaGALFPAALALIADLVPPERRGRALGLLGAGLgLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 170 LVGYMNTHYIIAALCAVTAIISFLFLRDSPAtanREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNN 249
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRP---AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 250 IYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLtMAALLGLGSG 329
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFL-LGFGFGLLFP 315
|
330 340 350
....*....|....*....|....*....|
gi 2519732639 330 SVFGWVGRAADPKNVGAVSGVIAAAGALGG 359
Cdd:COG2814 316 LLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-386 |
6.98e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.87 E-value: 6.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFWAWTIVGPLAKYYAkpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLV 98
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQ--ADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 99 LLVGLAGSmksFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFATGVFGAG-MVGTALSAFFTPRLMNLVGYMNT 176
Cdd:COG2271 90 LLFGFATS---FWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGgPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 177 HYIIAALCAVTAIISFlflrdspatanrevtplmpkiirafkvkstWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAE 256
Cdd:COG2271 167 FLILGLPGLLLALLRF------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 257 AAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALG-GVSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGSVFGWV 335
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGlLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALA 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2519732639 336 GRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAAHrnYFIGLTLLAV 386
Cdd:COG2271 297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG--YQAAFLLLAA 345
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-386 |
4.36e-23 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 99.95 E-value: 4.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 1 MSAPAAESYD-LKKGQLFNLLLITFASTVGFWAWTIVGPLAKYYAkpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTD 79
Cdd:COG2807 1 MSTTSSSARRsRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIR--ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 80 KYGGRIMMSLVLAVstpLVLLVGLAGSMKSFPLMLVFSFLLGIAGTVFAVGIPFSAAWYPPARKGFATGVFGAGM-VGTA 158
Cdd:COG2807 79 RFGLERTLLLALLL---LAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMgLGAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 159 LSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRDSPATANREVTPlmPKIIRAFKVKSTWQLCFLYSVVFGGFVA 238
Cdd:COG2807 156 LAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA--ASLRSLWRSPLAWLLTLFFGLQSLLYYA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 239 FSNYLPTYLNNiYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVT-AFQPDAehvygpIF 317
Cdd:COG2807 234 VVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGlLLAPGS------LP 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2519732639 318 LTMAALLGLGSGSVFGW-----VGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAAHrNYFIGLTLLAV 386
Cdd:COG2807 307 WLWAVLLGLGQGGLFPLaltliGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG-SWTAALLLLAA 379
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-363 |
3.44e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 93.64 E-value: 3.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 22 ITFASTVGFWAWTIVGPLAKYYAKpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLV 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLA-EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 102 GLAGSmksFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFATGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYI 179
Cdd:pfam07690 80 LFASS---LWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFgLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 180 IAALCAVTAIISFLFLRDSPATANREVTPLMPKIIRAFKV--KSTWQLCFLYSVVFG-GFVAFSNYLPTYLNnIYNFDAE 256
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAllRDPVLWLLLALLLFGfAFFGLLTYLPLYQE-VLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 257 AAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGG--VSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGSVFGW 334
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLliLAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*....
gi 2519732639 335 VGRAADPKNVGAVSGVIAAAGALGGFFPP 363
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
68-386 |
3.45e-21 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 93.79 E-value: 3.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 68 AVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSmksFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFA 146
Cdd:cd17319 52 ALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS---LTSLYVLRFLLGVAeAGFFPGAIKALAEWFPARERGRA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 147 TGVFGAG-MVGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRdspatanrevtplmpkiirafkvkSTWQL 225
Cdd:cd17319 129 TGLFNSGaPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR------------------------QVWGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 226 CFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKF-----GPKIITFIALGGVSALA 300
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgarRLVIIIGLLLAAVGLLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 301 LVTAFQPdaehVYGPIFLTMAA-LLGLGSGSVFGWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAAHrNYFI 379
Cdd:cd17319 265 AYLTTSP----VVAVILLSLAGfGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATG-SYTA 339
|
....*..
gi 2519732639 380 GLTLLAV 386
Cdd:cd17319 340 AFLFLAA 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-374 |
3.43e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.10 E-value: 3.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 22 ITFASTVGFWAWTIVGPLAKYYAKpeQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMM---SLVLAVSTPLV 98
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAE--SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLllgLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 99 LLVglagsmKSFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFATGVFGAGM-VGTALSAFFTPRLMNLVGYMNT 176
Cdd:cd17325 79 AFA------TSYWQLLLARFLQGLAsAAVWPAAMALIADIAPPEERGRAMGIFSSAIgLGFLIGPLLGGLLADALGYRAP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 177 HYIIAALCAVTAIISFLFLRDSPATANREVTPLMPK---IIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNF 253
Cdd:cd17325 153 FLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLrsgLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 254 DAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLtMAALLGLGSGSVFG 333
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLAL-LGLGLGLVFPATLA 311
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2519732639 334 WVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAAH 374
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-386 |
1.57e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.41 E-value: 1.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 22 ITFASTVGFWAWTIVGPLAKYYAKpeQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVstpLVLLV 101
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQ--SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLL---FALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 102 GLAGSMKSFPLMLVFSFLLGIAGTVFAVGIPFSAA-WYPPARKGFATGVFGAGM-VGTALSAFFTPRL--MNLVGYMNTH 177
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAdLFPERERGRALGLLQAFGsVGGILGPLLGGILasSLGFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 178 YIIAALCAVTAIISFLFLRDSPATANREVTPLMPK-----IIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYN 252
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKsvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 253 FDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGSVF 332
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2519732639 333 GWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAAHRNYFIGLTLLAV 386
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVL 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-386 |
3.56e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.38 E-value: 3.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 47 EQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSmksFPLMLVFSFLLGIAGTV 126
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS---FALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 127 F-AVGIPFSAAWYPPARKGFATGVFGAG-MVGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRDSPATANR 204
Cdd:cd17324 104 FwAIAAAYAADLVPPEKRGRAIGLVFSGlTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 205 EvTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFG 284
Cdd:cd17324 184 S-LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 285 PKIITFIALGGVSALALVTAFQPdaehvYGPIFLTMAALLGLGSGSVF----GWVGRAAdPKNVGAVSGVIAAAGALGGF 360
Cdd:cd17324 263 RRALLIALLLLAAALLLLTLLGP-----SPLLLLVGLVLWGLGFFAAHsalqTRVLRLA-PEARGLASSLYLAAYNLGGA 336
|
330 340
....*....|....*....|....*.
gi 2519732639 361 FPPLVMGATYDAAHRNYFIGLTLLAV 386
Cdd:cd17324 337 LGAALGGLVLDHGGWAGVGWVGAALL 362
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
23-374 |
7.70e-16 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 78.43 E-value: 7.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 23 TFASTVGFWAWTIVGPLAKYYAkpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVG 102
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQ--EDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 103 LAGsmkSFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFATGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYII 180
Cdd:cd17475 80 LVG---SYPVLLVLLFLVGAGyGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVpLGGALAAALLPPLALHYGWRAAFVVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 181 AALCAVTAIISFLFLRDSPA--TANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAA 258
Cdd:cd17475 157 GLVSILAAVLFWLFYREPPAasAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 259 GARAAGFAAAAVIARPFGGILADKFGP--KIITFIALGGVSALALVTAFQPDAEHVYGPIFLTMaALLGLgsgSVFGWVG 336
Cdd:cd17475 237 GALLAVAQLGGALGRIGLGRVSDRVFGgrRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLL-ILLGL---FAIGWNG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2519732639 337 RA-------ADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAAH 374
Cdd:cd17475 313 LYltlvaesAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATH 357
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-367 |
1.57e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 74.55 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFWAWTIVGPLakyYAKpeQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLV 98
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPL---YAH--DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 99 LLVGLAGSmksFPLMLVFSFLLGIAGTVFAVGIPFSAAWY-PPARKGFATGVFGAGM-VGTALSAFFTPRLMNLVGYmNT 176
Cdd:cd17489 76 LLYLLATS---VALLLVLRLIHGIGWGAFTTAAATLVADIiPPSRRGEGIGYYGLATtLAMALGPALGLFLYQHLGF-AV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 177 HYIIAALCAVTAIISFLFLRD--SPATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFsnyLPTYLNNIynfD 254
Cdd:cd17489 152 LFIVAAVLALLALLLVFLVKDppPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTF---LPLYAAER---G 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 255 AEAAGARAAGFAAAAVIARPFGGILADKFGPK--IITFIALGGVSALALVTAFQPdaehvygPIFLTMAALLGLGSGSVF 332
Cdd:cd17489 226 ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKtvIIPGLLLLALGLLLLSFAGSP-------WMLLLAAVLYGLGFGLLF 298
|
330 340 350
....*....|....*....|....*....|....*....
gi 2519732639 333 ----GWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMG 367
Cdd:cd17489 299 palqALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLG 337
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-373 |
3.73e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 73.35 E-value: 3.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 16 LFNLLLITFAST-VGFWAWTIVGPLAKyyakpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVS 94
Cdd:COG0738 9 ALIAIYLLFFLWgFATALWGPLIPALK-----DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 95 TPLVLLVGLAGSmksFPLMLVFSFLLGIAGTVFAVGIPFSAAWYPPARKGFATGVFGAG-MVGTALSAFFTPRLMNL--- 170
Cdd:COG0738 84 ALGLLLFALAPS---YPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFfSLGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 171 VGYMNTHYIIAALCAVTAIISFLFLRDSPATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNI 250
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 251 YNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDAehvygPIFLTMAALLGLGSG- 329
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGP-----WLALIGLALVGLGLSl 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2519732639 330 ---SVFGWVGRAAdPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAA 373
Cdd:COG0738 316 mfpTIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAF 361
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-369 |
4.38e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.32 E-value: 4.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 11 LKKGQLFNLLLITFAStvGFWAWTIVGPLAKYYAkpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGR------ 84
Cdd:COG2211 7 LSLKEKLAYGLGDLGL--NLAFGLLSAYLLYFYT--DVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrp 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 85 --IMMSLVLAVSTPLVLLVGLAGSMKSFPLMLVFSFLLGIAGTVFavGIPFSAaWYP-----PARKGFATGV-FGAGMVG 156
Cdd:COG2211 83 wiLIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLV--NIPYSA-LGAeltpdYEERTRLSSWrFAFAGLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 157 TALSAFFTPRLMNLV------GYMNTHYIIAALCAVTAIISFLFLRDSPATAnREVTPLMPKIIRAFKVKSTWQLCFLYS 230
Cdd:COG2211 160 GLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPE-EEKVSLKESLKALLKNRPFLLLLLAYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 231 VVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKiITFIALGGVSALALVTAFQPDAE 310
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKK-KAFIIGLLLAALGLLLLFFLGPG 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2519732639 311 HVYGPIFLTMAALLGLGSGSVFGWV-------------GRAADPKNVGAVSGVIAAAGALGGFFPPLVMGAT 369
Cdd:COG2211 318 NLWLLLVLAALAGIGLGAILVLPWAmladvvdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
32-374 |
1.85e-12 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 68.41 E-value: 1.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 32 AWTI-VGPLAKYyakpeqMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSmkSF 110
Cdd:cd17353 21 AWSVfNPPLSSA------LGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAIS--LP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 111 PLMLVFSFLLGI-AGTVFAVGIPFSAAWYPPaRKGFATGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTA 188
Cdd:cd17353 93 LLFLGYGVLGGIgAGIGYITPVSTAVKWFPD-KRGLATGIVIAGFgLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIII 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 189 IISFLFLRDSPA----------TANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAA 258
Cdd:cd17353 172 VIGAFLIRDPPKgwvppgvdplANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 259 GARAAGFAAAAVIARPFGGILADKFGPKIITFIALGgvsALALVTAFQPDAEHVYGpIFLTMAALLGLGSGSVFG----W 334
Cdd:cd17353 252 ALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFL---IQGVAMFLLPFIGSVAV-LFVLGVALIGFCYGGGFAlfpaL 327
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2519732639 335 VGRAADPKNVGAVSGVIAAAGALGGFFPPLVmGATYDAAH 374
Cdd:cd17353 328 TADFFGTKNAGTNYGLLYTAKGVGGLIGPII-AAYVLYTG 366
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
54-374 |
4.02e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 67.30 E-value: 4.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 54 GTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSmksfPLMLVFSFLL---GIAGTVFAVG 130
Cdd:cd17355 38 AVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS----LWQLYLLWGLlggGGAGTLAAVA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 131 IPFSAAWYPPARKGFATGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRDSPATANREVTPL 209
Cdd:cd17355 114 FATVAAWWFERRRGLALGILTAGGgLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDD 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 210 MPKII------RAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYnFDAEAAGARAAGFAAAAVIARPFGGILADKF 283
Cdd:cd17355 194 ASPASpgstlkEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRG-ISPAAAAVALALIGLFNIVGRLLSGWLGDRY 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 284 GPKIITFIALGGVSALALVTAFQPDAehvyGPIFLTMAALLGLGSGSVF----GWVGRAADPKNVGAVSGVIAAAGALGG 359
Cdd:cd17355 273 SPRRLLAASYALRALGLALLLLLPFP----PLALLLFAALFGLGWGATVpltaALAARYFGARSYGTLFGLVFAPHQLGS 348
|
330
....*....|....*
gi 2519732639 360 FFPPLVMGATYDAAH 374
Cdd:cd17355 349 ALGPWLGGLLYDRTG 363
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
68-367 |
1.27e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.39 E-value: 1.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 68 AVGRIPIGGLTDKYGGRIMMSLVLAVSTplVLLVGLAGSMkSFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFA 146
Cdd:TIGR00881 44 GISKFVMGSVSDRSNPRVFLPIGLILCA--IVNLFFGFST-SLWVMAALWALNGIFqGMGWPPCGRTVTKWFSRSERGTW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 147 TGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVT-AIISFLFLRDSPATA---------NREVTP------- 208
Cdd:TIGR00881 121 VSFWNCSHnVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIvSLICFLLLRDSPQSCglppaeempNEEPDGdaekkee 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 209 -LMPKIIRAFKV---KSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKF- 283
Cdd:TIGR00881 201 eLTKKQIFLQYVllnKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLf 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 284 -GPK-IITFIALGGVSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGSVFGWVGRAADPKN-VGAVSGVIAAAGALGGF 360
Cdd:TIGR00881 281 nGRRgPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKaAGTAAGFVGFFAYLGGI 360
|
....*..
gi 2519732639 361 FPPLVMG 367
Cdd:TIGR00881 361 LAGLPLG 367
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
68-386 |
1.53e-10 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 62.29 E-value: 1.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 68 AVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAgsmKSFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFA 146
Cdd:cd17312 52 AVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS---TSLWFFAVLWGLNGLFqSMGWPPCVKLLGNWFSKKERGTV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 147 TGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRDSPatanrevtPLMpkiirafkvkstWQL 225
Cdd:cd17312 129 YGIWSTSHnFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP--------PYV------------WVL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 226 CFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGP----KIITFIALGGVSALAL 301
Cdd:cd17312 189 SLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGgrraPIAVIYMLLMTLSLAL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 302 VTaFQPDAEhVYGPIFLTMAALLGLGSGSVFGWVGRAADPKN--VGAVSGVIAAAGALGGFFPPLVMG---ATYDAAHRN 376
Cdd:cd17312 269 FW-FFPHNK-LLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKeaAGTATGFVGLFGYLGASLAGLPLGyiiDHYGWSTVF 346
|
330
....*....|.
gi 2519732639 377 YF-IGLTLLAV 386
Cdd:cd17312 347 YFlISAALLSV 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
19-386 |
1.20e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.51 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFWAWTIVGPLAKYYAkpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLV 98
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIA--EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 99 LLVGLAGsmkSFPLMLVFSFLLGI-AGTVFAVGIPFSAAWYPPARKGFATGVFGAGM-VGTALSafftPRLMNLVGYMNT 176
Cdd:cd17474 79 LLCGLSD---SFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALgLGIAVG----PLLGGLLAAISW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 177 HY---IIAALCAVTAIISFLFLRDSPATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNF 253
Cdd:cd17474 152 RYpffLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 254 DAEAAGARAAGFAAAAVIARPFGG-ILADKFGPKIITFIALGGVSALALVTAFQPDAehvygPIFLTMAALLGLGSGSVF 332
Cdd:cd17474 232 SPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSL-----ALLLIAIVLFGLGLGLNL 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2519732639 333 ----GWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAA-HRNYFIGLTLLAV 386
Cdd:cd17474 307 plltTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFgLSAPFLVGAAIAL 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
19-368 |
1.66e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.77 E-value: 1.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFWAWTIVGPLAKYYAKPEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLV 98
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 99 LLVGLAGSmksFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFATG-VFGAGMVGTALSAFFTPRLMNLVGYMNT 176
Cdd:cd17316 81 LLIGLLPT---PILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGlLQSGWALGALLAALVASLLIPLLSGDWG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 177 HYIIAALCAVTAIISFLFLRdspatanrevtplmpkiirafkvkSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAE 256
Cdd:cd17316 158 WRILFLIGALPALLALLLRR------------------------RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 257 AAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGSVFGWVG 336
Cdd:cd17316 214 TSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYL 293
|
330 340 350
....*....|....*....|....*....|...
gi 2519732639 337 RAADPKNVGAV-SGVIAAAGALGGFFPPLVMGA 368
Cdd:cd17316 294 AELFPTEVRATgVGLSYNLGRLGGGGAPPLIAL 326
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-351 |
2.72e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.34 E-value: 2.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 47 EQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSmksFPLMLVFSFLLGIAGTV 126
Cdd:cd17478 24 AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN---YWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 127 FAVGIPFSAAWYPPARKGFATGVFGA-GMVGTALSAFFTPRLMNLVGYMNThYIIAALCAVTAIISFLFLRDSPATANRE 205
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVgGNLGFALGPLIAAALVALFGGLGL-LILLIIPGLAVALLLLRLRPLKKPEAKK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 206 VTPLMPKIIRAFKVKST----WQLCFLYSVVFggfVAFSNYLPTYLNNiYNFDAEAAGARAAGFAAAAVIARPFGGILAD 281
Cdd:cd17478 180 AAAKSSARSTLKGVWRAllllLIIVFLRSWVL---SSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSD 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 282 KFGPKIITFIALGGVSALALVTAFQPDaeHVYGPIFLTMAALLGLGSGSVFGWVGRAAdPKNVGAVSGVI 351
Cdd:cd17478 256 RFGRRRVIIASLLLAAPFLLLFLLTPG--IWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLASGLM 322
|
|
| PRK15034 |
PRK15034 |
nitrate/nitrite transport protein NarU; Provisional |
58-369 |
3.40e-09 |
|
nitrate/nitrite transport protein NarU; Provisional
Pssm-ID: 184994 [Multi-domain] Cd Length: 462 Bit Score: 58.36 E-value: 3.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 58 LLVAMPIFIGAVGRIPIGGLTDKYGGR--IMMSLVLAVSTPLVLLVGLAGSMKSFPLMLVFSFLLGIAGTVFAVGIPFSA 135
Cdd:PRK15034 74 LLTALPSVSGALLRVPYSFMVPIFGGRrwTVFSTAILIIPCVWLGIAVQNPNTPFGIFIVIALLCGFAGANFASSMGNIS 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 136 AWYPPARKGFATGVFGA-GMVGTALSAFFTPRLM------------------NLVGYMNTHYIIAALCAVTAIISFLFLR 196
Cdd:PRK15034 154 FFFPKAKQGSALGINGGlGNLGVSVMQLVAPLVIfvpvfaflgvngvpqadgSVMSLANAAWIWVPLLAIATIAAWSGMN 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 197 DSpATANREVTPLMPKIIRAfkvkSTWQLCFLYSVVFGGFVAFSNYLPTYLNNiyNFDAEAAGARAAGFAAAAVIARPFG 276
Cdd:PRK15034 234 DI-ASSRASIADQLPVLQRL----HLWLLSLLYLATFGSFIGFSAGFAMLAKT--QFPDVNILRLAFFGPFIGAIARSVG 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 277 GILADKFGP---KIITFIALGGVSALALVTAFQPDAEH--VYGPIFLTMAALLGLGSGSVF------------------G 333
Cdd:PRK15034 307 GAISDKFGGvrvTLINFIFMAIFSALLFLTLPGTGSGNfiAFYAVFMGLFLTAGLGSGSTFqmiavifrqitiyrvkmkG 386
|
330 340 350
....*....|....*....|....*....|....*....
gi 2519732639 334 WVGRAADPKNV---GAVSGVIAAAGALGGFFPPLVMGAT 369
Cdd:PRK15034 387 GSDEQAQREAVtetAAALGFISAIGAVGGFFIPQAFGMS 425
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
19-372 |
5.50e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.20 E-value: 5.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFwawTIVGPLAKYYAKP-EQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPL 97
Cdd:cd17330 1 LFLVVFLDALGF---GIVFPVLPFYVREfNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 98 VLLVGLAGSmksFPLMLVFSFLLGIAGTVFAVGIPFSAAWYPPA--RKGFA--TGVFGAGMV-GTALSAFftprLMNLVG 172
Cdd:cd17330 78 YVLLGLSRN---LWLLFLARFLDGLTGGNVSVAQAYIADITDEEerAKAFGiiSAAFGLGFIlGPALGGF----LSTPYG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 173 YMNTHYIIAALCAVTAIISFLFLRdspatanrevtplmpkiirafkvkSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYN 252
Cdd:cd17330 151 YALPFLVAAALALLNLVLVLFFLP------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 253 FDAEAAGARAAGFAAAAVIAR-PFGGILADKFGPKIITFIALGGVSALALVTAFQPdaehvYGPIFLTMAALLGLGSGSV 331
Cdd:cd17330 207 FSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFAS-----SVPLLVLAAAILAFGTGIV 281
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2519732639 332 F----GWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDA 372
Cdd:cd17330 282 FpalsALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSF 326
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
50-367 |
1.03e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.60 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 50 NLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSmksFPLMLVFSFLLGIA-GTVFA 128
Cdd:TIGR00895 48 GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN---VTQLLILRFLAGLGlGGLMP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 129 VGIPFSAAWYPPARKGFATGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRDS--------P 199
Cdd:TIGR00895 125 NLNALVSEYAPKRFRGTAVGLMFCGYpIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESidflvskrP 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 200 ATANREVTPLMPK-------------------------IIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPtYLNNIYNFD 254
Cdd:TIGR00895 205 ETVRRIVNAIAPQmqaeaqsalpeqkstqgtkrsvfkaLFQGKTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 255 AEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIAL-GGVSALALV-TAFQPDaehvygpIFLTMAALLGL----GS 328
Cdd:TIGR00895 284 LSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLlGAVFAVLVGsTLFSPT-------LLLLLGAIAGFfvngGQ 356
|
330 340 350
....*....|....*....|....*....|....*....
gi 2519732639 329 GSVFGWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMG 367
Cdd:TIGR00895 357 SGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-199 |
1.03e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.42 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 16 LFNLLLITFASTVGFWAWTIVGPLAKYYAKpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYG--GRIMMSLVLAV 93
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTYLV-EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 94 STPLVLLVGLAGSMksfPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFATGVFG-AGMVGTALSAFFTPRLMNLV 171
Cdd:COG2271 258 AALALLLLALLPSP---ALAIALLFLAGFGlGGAFGLLWALAAELFPKKARGTASGLVNtFGFLGGALGPLLVGYLLDAT 334
|
170 180
....*....|....*....|....*...
gi 2519732639 172 GYMNTHYIIAALCAVTAIISFLFLRDSP 199
Cdd:COG2271 335 GYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
55-332 |
3.30e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.89 E-value: 3.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 55 TTSLLVAMPIFIgavgriPIGG-LTDKYGGRIMMSLVLAVSTPLVLLVGLAGSmksFPLMLVFSFLLGIAGtvfAVGIPF 133
Cdd:cd17503 37 ITSYLLALAIMI------PLSGwLADRFGTRRLFLTALALFTLGSLLCGLAPN---LASLIIFRILQGFGG---GVLIPL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 134 S----AAWYPPARKGFATGVFGAGM-----VGTALSAFftprlmnLVGYMNTHYIIAALCAVTAIISFLflrdspatanr 204
Cdd:cd17503 105 AqtilLRIYPPEKRGAAMGLVGLVIllapaIGPTLGGW-------LTDNLSWRWIFYINLPIGILALLL----------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 205 evTPLMPkiIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFG 284
Cdd:cd17503 167 --APLLD--LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFG 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2519732639 285 PKIitfIALGGVSALALVTAFQPDA-EHVYGPIFLTMAALLGLGSGSVF 332
Cdd:cd17503 243 PRL---LLLAGLLLLALGTLLLAFLtPDTSLWLIILPLFIRGLGMGLVF 288
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-368 |
6.90e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.12 E-value: 6.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 46 PEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGsmkSFPLMLVFSFLLGIAGT 125
Cdd:cd17504 23 QREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAP---NLPVLIAGRALQGIGGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 126 VFAVGIPFSAAWYPPARKGFATGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIisflflrdspatanr 204
Cdd:cd17504 100 VFPLAFALVREEFPPERVPVAQGILSATFgIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA--------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 205 eVTPLMPkiIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNN----IYNFDAEAAGARAAGFAAAAVIARPFGGILA 280
Cdd:cd17504 165 -LVPLID--LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 281 DKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGSVFGWVGRAADPKNVGAVSGVIAAAGALGGF 360
Cdd:cd17504 242 ARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSA 321
|
....*...
gi 2519732639 361 FPPLVMGA 368
Cdd:cd17504 322 IGPAIAGA 329
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
68-368 |
8.26e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 53.72 E-value: 8.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 68 AVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSmksFPLMLVFSFLLGI-AGTVFAVGIPFSAAWYPPARKGFA 146
Cdd:cd17321 45 AALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS---LAFLIAARALQGIgAAAIMPASLALIAATFPGERRGRA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 147 TGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRDSpatanrevtplmpkiirafkvkstwql 225
Cdd:cd17321 122 LGLWGAVVgIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTFSGAV--------------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 226 cFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFI--ALGGVSALALVT 303
Cdd:cd17321 175 -LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAglLLTAVGLLLLAL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2519732639 304 AFQPDAEHVYGPIFLTMAALLGLGSGSVFGWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGA 368
Cdd:cd17321 254 LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGA 318
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
72-360 |
3.04e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 51.79 E-value: 3.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 72 IPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSMkSFPLMLVFSFLLGIAGtvfAVGIP----FSAAWYPPARKGFAT 147
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYS-SLPLLILSRILLGLGE---GVHFPsmtsLFSRWVPVSERSRAV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 148 GVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRdspatanrevtplmpkiirafkvkSTWQLC 226
Cdd:cd17380 128 SIVTAGSyLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP------------------------PVWAII 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 227 FL-YSVVFGGFVAFSnYLPTYLNNIYnFDAEAAGARAAGFAAAAVIARPFGGILADKF---------GPKIITFIALGGv 296
Cdd:cd17380 184 VAhFCMNWGFYILLS-WLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLisrgwtvtsVRKLMQSIGFLG- 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2519732639 297 SALALVtaFQPDAEHVYGPIFLtMAALLGLGSGSVFGWVGRAAD--PKNVGAVSGVIAAAGALGGF 360
Cdd:cd17380 261 PALFLL--LLSHTDSFSLALLC-MSVALGLSAFSSSGVLVNHQDiaPNYAGIVFGISNTAGTIPGI 323
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
19-371 |
3.68e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 3.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFWAwtiVGPLAKYYAKpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLV 98
Cdd:cd17329 4 LLIGSFLNRLGFFM---VWPFMAIYLH-QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 99 LLVGLAGsmkSFPLMLVFSFLLGIAGTVFavgIPFSAAW----YPPARKGFATGVFGAG-----MVGTALSAFFtprlmn 169
Cdd:cd17329 80 ALLGFAH---SPWLFAIALVLTGFGGGLF---EPASEAMiadvTTPENRTRAFSLLYWAinlgvAIGPLLGGLL------ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 170 LVGYMNTHYIIAALC--AVTAIISFLFLRDSPATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYL 247
Cdd:cd17329 148 LLYSFRLLFLAAAVLflLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 248 NNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDaehvYGPIFLTMAAL-LG- 325
Cdd:cd17329 228 VEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANT----LAVLILAMIVLtLGe 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2519732639 326 -LGSGSVFGWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYD 371
Cdd:cd17329 304 mLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD 350
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
72-368 |
3.20e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.77 E-value: 3.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 72 IPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSMkSFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPA-RKGFATGV 149
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARG-GYGALIVLRILQGLAqGVTFPAMHALWAKWAPPLeRSRLTSIA 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 150 FGAGMVGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFlrdspatanrevtplmpkiirafkVKSTWQLCFLY 229
Cdd:cd17318 153 YSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL------------------------VLPVWAIVVAH 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 230 SVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADK----------FGPKIITFIALGGVSAL 299
Cdd:cd17318 209 FGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWlrsrgilsttTVRKLFTSIGFLGPGVF 288
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2519732639 300 ALVTAFQPDaEHVYGPIFLTMAalLGLGSGSVFGWVGRAAD--PKNVGAVSGVIAAAGALGGFFPPLVMGA 368
Cdd:cd17318 289 LIALGYLGS-NATLAVVFLTLS--VGLSGACYSGFLVNHLDlaPNYAGTLMGITNTAATIAGIISPLIVGA 356
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
49-249 |
5.63e-06 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 48.06 E-value: 5.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 49 MNLNPGTTSLLVAMPIFIGavgripiggLTDKYGGRI---MMSLVLAVSTPLVLLVGLAGSMKsfPLMLVFSFLLGIAGT 125
Cdd:cd17397 43 LLANWGPIGFVPTFFFMAW---------LMDVKGLRIavlSSAFLVAAGTGLRCIPVPNHLAT--WLIHIGQFLNGLAGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 126 VFAVGIPF-SAAWYPPARKGFATGVfgagmvgTALSAFFTPRLMNLVG---YMNTHYIIAALCAVTAIISFLFLRDSP-- 199
Cdd:cd17397 112 VAMAAAPFlSATWFPPNQRATATAI-------ASIFNYLGGAASFLIGplvLMYLEFGWSALIFLAMLIYFPSKPPTPps 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2519732639 200 ATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNN 249
Cdd:cd17397 185 VSASTQRLSYKSGILSLLKNKRFWLIALAYGIPTGVYAGWSGVLDVNLTP 234
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
27-324 |
2.44e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 46.13 E-value: 2.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 27 TVGFWAWTIVGPLAKYYAkPEQMNLNPGTTSLLVAMPIF-IGAVGRiPIGG-----LTDKYGGRIMM----------SLV 90
Cdd:cd17367 9 LVEWYDWYVYAAFALYFA-PQFFPSGDPTVALLSTAAVFaVGFLMR-PIGGwlfgrLADRIGRRAALtlsvslmaagSLV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 91 LAVsTPLVLLVGLAGsmksfPLMLVFSFLLgiagTVFAVGIPFSA-AWY-----PPARKGFATG------VFG---AGMV 155
Cdd:cd17367 87 IAV-TPTYATIGIWA-----PIILLLARLL----QGLSVGGEYGTsATYlsevaPPGRRGFYSSfqyvtlIGGqllALGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 156 GTALSAFFTPRLMNLVGYmNTHYIIAALCAVTAIISFLFLRDSPATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGG 235
Cdd:cd17367 157 LLVLQHTLGEDQMAAWGW-RIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELRRHPRELLLVVGLTAGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 236 ---FVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPK-IITFIALGGVSALALVTAFQPDAEH 311
Cdd:cd17367 236 tlaFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRpLLLFFGIGGTLATVPLLSALDHTDS 315
|
330
....*....|...
gi 2519732639 312 VYGPIFLTMAALL 324
Cdd:cd17367 316 PYTAFALVLVGLV 328
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
50-333 |
3.85e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.37 E-value: 3.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 50 NLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSmksFPLMLVFSFLLGIA-GTVFA 128
Cdd:cd17371 30 GLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQN---YWQLLILRALAGLGfGGEWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 129 VGIPFSAAWYPPARKGFATG-VFGAGMVGTALSAFFTPRLMNLVGYM---NTHYIIAALCAVTAIISFLFLRDSP----A 200
Cdd:cd17371 107 AGAALMAEYVPARHRGKALGyVQSGWAVGWLLATLLAALLFPLLPPEiawRVLFLLGALPALLVLFIRRFVKEPPqwqaA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 201 TANREVTPLMPKIIRAF--KVKSTWQLCFLYSV-VFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGG 277
Cdd:cd17371 187 RAARRHFADRPSLRELFspPLLRTTLLASLLATgALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGG 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2519732639 278 ILADKFGPK-IITFIALGGVSALALVTAFQPDAEhvygpIFLTMAALLGLGSGSVFG 333
Cdd:cd17371 267 FLADRIGRRnNFALFALGSAISILLYFFLPLSPT-----LILILGFPLGFFASGPFS 318
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
53-368 |
4.04e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 4.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 53 PGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRimmsLVLAVSTPLVLLVGLAGSM-KSFPLMLVFSFLLGIA-GTVFAVG 130
Cdd:cd17473 34 ELLVPLLLTLPALFIALFAPLAGWLADRFGRK----RLLIAGLLLYGIGGVAGLFlDSLYALLASRALLGIGvAGIMTLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 131 IPFSAAWYPPARKGFATGVFGAGMVGTALSAFFtprLMNLVGYMNTHYI--IAALCAVTAIISFLFLRDsPATANREVTP 208
Cdd:cd17473 110 TALIGDYFEGEERAKMLGLQSAAMSLGGVVFLL---LGGALAEIGWRAPflVYLLALPVLILVLLFLPE-PARKSKSAAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 209 LMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKII 288
Cdd:cd17473 186 PGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 289 TFIALGGVSALALVTAFQPDAehvygPIFLTMAALLGLGSG----SVFGWVGRAADPKNVGAVSGVIAAAGALGGFFPPL 364
Cdd:cd17473 266 LAIGFALMALGFLLLALASGL-----WVVLLGAILAGLGFGlllpTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
|
....
gi 2519732639 365 VMGA 368
Cdd:cd17473 341 VLGP 344
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
56-199 |
6.47e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 44.96 E-value: 6.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 56 TSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSMKSFPLMLVFSFLLGIAGTVFAVGIPFSA 135
Cdd:pfam00083 48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYI 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2519732639 136 AWY-PPARKGFATGVFGAGMVGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISF---LFLRDSP 199
Cdd:pfam00083 128 SEIaPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIiglLFLPESP 195
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
47-386 |
1.06e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 47 EQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSMksfPLMLVFSFLLGIAGTV 126
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP---WVWFLLRFVMGIGLAG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 127 FAVGIPFS-AAWYPPARKGFATGVFgagMVGTALSAFFTPRLMNLVG-YMNTHYIIAALCAVTAIISFLFLRDSPATANR 204
Cdd:cd17477 101 LFVVSESWlNALATNENRGRVLGLY---STVLGLGFALGPLLLALVGtAGALPFLIAAVLLLLALVPLLLTRRAAPEIEE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 205 EVTPLMPKIIRAFKVKSTwqLCFLYSVVFGGFVAFsnyLPTYLNNIyNFDAEAAGARAAGFAAAAVIARPFGGILADKFG 284
Cdd:cd17477 178 AESISLRRLLRIAPLALL--GAFVAGFLEGAFYSL---LPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 285 PK--IITFIALGGVSALALVTAFQpdaehvYGPIFLTMAALLGLGSGSVF----GWVGRAADPKNVGAVSGVIAAAGALG 358
Cdd:cd17477 252 RRrvLLGCALLGALAALLLPLVPG------LPLALLVLLFLWGGAAGPLYtlalALAGDRLPGDELVAANAALLLLYGLG 325
|
330 340
....*....|....*....|....*....
gi 2519732639 359 GFFPPLVMGATYDAA-HRNYFIGLTLLAV 386
Cdd:cd17477 326 SVIGPLLAGALMDAFgPHGLFLFLAAVAL 354
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
48-194 |
1.22e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 48 QMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSMkSFPLMLVFSFLLGIAGTVF 127
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGL-PLALLVLLFLWGGAAGPLY 295
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2519732639 128 AVGIPFSAAWYPPARKGFATGVFGA-----GMVGTALSAFftprlmnLVGYMNTHYIIAALCAVTAIISFLF 194
Cdd:cd17477 296 TLALALAGDRLPGDELVAANAALLLlyglgSVIGPLLAGA-------LMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
71-367 |
1.31e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.75 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 71 RIPIGGLTDKYGGR----IMMSLVLAVSTPLVLLVGlagsmkSFPLMLVFSFLLGIAGTVFAVGIPFSAAWYPPARKGFA 146
Cdd:cd17490 48 RIPLGILSDRIGKRklfiIIGLLFTVLASLIMILFP------SPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 147 TGVFGAGMVGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRDSPATANREVTPLMpKIIRAFKVKSTWQLC 226
Cdd:cd17490 122 MGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELK-ELLSVLKDKKLLFFS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 227 FLYSVVFG-GFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAF 305
Cdd:cd17490 201 LLAILQQMiTFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPF 280
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2519732639 306 QPDAehvygPIFLTMAALLGLGSGSVF----GWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMG 367
Cdd:cd17490 281 APNL-----TLLYLLQALNGFGTGILFpllmSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVG 341
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
19-199 |
1.68e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 43.34 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFWAWTIVGPLAKYYAK---PEQMN---LNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLA 92
Cdd:cd17365 165 ILLPLLRGTLLLWVTFFMGLLLVYLLNswlPKLMVeagYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFA 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 93 VStpLVLLVGLAGSMKSFPLMLVFSFLLGIAGTVFAVGIP-FSAAWYPPARKGFATG-VFGAGMVGTALSAFFTPRLMNL 170
Cdd:cd17365 245 LG--AVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYaLAARFYPTEVRATGVGwALGVGRLGAILGPLLGGLLLAA 322
|
170 180
....*....|....*....|....*....
gi 2519732639 171 VGYMNTHYIIAALCAVTAIISFLFLRDSP 199
Cdd:cd17365 323 GLGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
49-368 |
4.27e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.21 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 49 MNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDK----YGGR----IMMSLVLAVSTPLVLLVGLAGSMKSFPLMLVFSFLL 120
Cdd:cd17332 30 LGLSAAAAGTIFLVARIIDAINDPLMGYLIDRtrsrWGRFrpwlLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 121 GIAGTvfAVGIPFSAawYPPA-------RKGFATGVFGAGMVGTALSAFFTPRLMNLVGYMNTHY-------IIAALCAV 186
Cdd:cd17332 110 DLLYT--LVNIPYTA--LIPEltddpeeRTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRgyfltalIIGIIGII 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 187 TAIISFLFL--RDSPATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNniYNFDAEAAGARAAG 264
Cdd:cd17332 186 LLLICFFGTreRVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFK--YVLGGRAELVLLLL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 265 FAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGSVFGWV--------- 335
Cdd:cd17332 264 LILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAmladvidyg 343
|
330 340 350
....*....|....*....|....*....|....*..
gi 2519732639 336 ----GRAADPKNVGAVSGVIAAAGALGGFFPPLVMGA 368
Cdd:cd17332 344 elktGKRREGIFYSVMTFFRKLGLALAGALVGLILSL 380
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
72-251 |
5.21e-04 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 41.84 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 72 IPIGGLTDKYGGRIMmSLVLAVSTPLVLLVGLAGSMKS-FPLMLVFSFLLGIAgTVFAVGIP--FSAAWYPPARKGFAT- 147
Cdd:cd17398 57 FPATWLLEKYGLRVT-VLLGSFLNCLGAWLKLFSSSPDlFWVAMAGQTICALA-QVFILGIPprLAAVWFGPDEVSTATa 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 148 -GVFGAGM---VGTALSAFFTPRLMNL----VGYMNTHYIIAALCAVTAIISFLFLRDSPAT--------ANREVTPLMP 211
Cdd:cd17398 135 iGVFGNQLgvaLGFVLPPLLVPNSENKdeigKGLSILFYGVAGICTALFILVIIFFKEKPPIppsraqaaAQELRSEDQS 214
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2519732639 212 ---KIIRAFKVKSTWQLCFLYSVVFGGFVAFSnylpTYLNNIY 251
Cdd:cd17398 215 ylgSLKRLFKNKGFLLLLITYGINTGVYYAIS----TLLNQMV 253
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
69-367 |
5.32e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.92 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 69 VGRIPIGGLTDKYGGRIMMSLVLAVstpLVLLVGLAGSMKSFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYP---PARKG 144
Cdd:cd17333 46 IGSLLAGFLMKRLGRRRTLILGLLL---ISLALALIFATPSIYLFVVLMFLAGLGaGILDTGANTFVGALFEessATRLN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 145 FATGVFGAGmvGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLrdSPATANREVTPLMPKIIRAFKVKSTWQ 224
Cdd:cd17333 123 VLHGFFGLG--ALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTL--FPELPSARNPQQSVGAFSASASRLLRN 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 225 LCFLYSVVF-----GGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSAL 299
Cdd:cd17333 199 PSIILGALAlflyvGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLG 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2519732639 300 ALVTAFqpdaehVYGPIFLTMA-ALLGLGSGSVFG---WVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMG 367
Cdd:cd17333 279 LLILLL------APTLVVGLVAtALLGLFMAALFPtilSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
75-254 |
7.50e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.46 E-value: 7.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 75 GGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSMKSfpLMLVFSFLLGIAGTVFAVGIPFSAA----WYPPARKGFATGV- 149
Cdd:cd17345 59 GNLSDRSNPKRFLAIGLILSAIINILIGFVPSATS--SVGLMFILLFLNGWFQGMGWPPSGRtmvhWFSKKERGTWTSIw 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 150 -----FGAGMVGTALSAfftprLMNLVGYMNTH--YIIAALCA-VTAIISFLFLRDSP-------------------ATA 202
Cdd:cd17345 137 nishnVGGGLVGPLAGL-----GLAIFGDGWWRgaFIFPAIIAiIVAVIVLFLGKDTPeseglppieeykgdypeeaDGE 211
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2519732639 203 NREVTPLMPKIIR--AFKVKSTWQLC----FLYSVVFGgfvaFSNYLPTYLNNIYNFD 254
Cdd:cd17345 212 EEEQELSAWEIFVkyVLKNKLLWYIAianvFVYLVRYG----ILDWAPTYLSEVKGFS 265
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
69-359 |
9.73e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 41.08 E-value: 9.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 69 VGRIPIGGLTDKYGGRIMMSlVLAVSTPLVLLvgLAGSMKSFPLMLVFSFLLGIAGTVFAVG-IPFSAAWYPPARKGFAT 147
Cdd:cd17327 56 IFELPGNLLLQRFPPSKWLS-VFIVLWGLLTL--LTAAVKNFGGLIALRFFLGLFESGVFPGfILYLGMWYKREEQAKRI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 148 GVF-GAGMVGTALSAFFTPRLM------NLVGYMNTHYIIAALCAVTAIISFLFLRDSPATA---NREVTPLMPK----- 212
Cdd:cd17327 133 AFFyAAAGLGSIFGGLLAYGVFkilgvgGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAwflTEEEKELAVErlran 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 213 -------------IIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIyNFDAEAAGARAAGFAAAAVIARPFGGIL 279
Cdd:cd17327 213 qtgkgdqkfkwkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSL-GFYSLQTNLLSVPIGALGAVSLLIAALL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 280 ADKFGPKIITFIAlGGVSALA--LVTAFQPDAEHVYGpIFLTMAALLGLGSGSVFGWV-GRAADPKNVGAVSGVIAAAGA 356
Cdd:cd17327 292 SDRFKKRGLFAIF-ACVLALVgsIILLAAPNPPGAYF-AAYILGGGSYAGFPILLSWIsSNCAGYTKRATVLAIMLIFYN 369
|
...
gi 2519732639 357 LGG 359
Cdd:cd17327 370 VGN 372
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
74-234 |
1.38e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 40.78 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 74 IGG-LTDKYGGRIMMSLVLAVSTPLVLLVGlagsmkSFPLMLVFSFLLGIAGTVFAVGIPFSA----AWYPPARKGFATG 148
Cdd:cd17343 57 IGGvLSDQISARWLFSSGLVLSGLTTVAFS------GSSSVWVFSILWFLNGLAQGLGWPPCAkilrKWFSPSQFGTWWS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 149 VFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFLRDSPA---TANREVTPLMPKIIRAFKVKSTWQ 224
Cdd:cd17343 131 VLSTSMnLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSdvgLNNIEEEESKGKKKKSPRGESTLK 210
|
170 180
....*....|....*....|
gi 2519732639 225 ----------LCFLYSVVFG 234
Cdd:cd17343 211 elllspflwlLSLGYLVVFG 230
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-217 |
1.90e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.79 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFWAWTIVGPLAKYYAKpeQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLV 98
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAA--DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 99 LLVGLAGSMksfPLMLVFSFLLGI-AGTVFAVGIPFSAAWYPPARKGFATGVFGAGMvgtALSAFFTPRLMNLVGYMNTH 177
Cdd:COG0477 94 LLCGLAPSP---ELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAI---GLGLALGPLLGGLLVAALGW 167
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2519732639 178 YIIAALCAVTAIISFLFLRDSPATANREVTPLMPKIIRAF 217
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALL 207
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
47-385 |
1.91e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 47 EQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSMKSFplMLVFSFLLGiagtv 126
Cdd:cd17352 31 EEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQL--YLTYGVLGG----- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 127 FAVGIPFSAA-----WYPPARKGFATGVFGAGM-VGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISFLFlrdspa 200
Cdd:cd17352 104 LGLGLIYSPAivivgQYFEKKRGLATGIAVAGSgVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLL------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 201 tanrevtplmpkiiRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNiYNFDAEAAGARAAGFAAAAVIARPFGGILA 280
Cdd:cd17352 178 --------------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 281 DKFGPKIITfIALGGVSALALVTAFQPDAEHVYGpiFLTMAALLGLGSGSVFGW----VGRAADPKNVGAVSGVIAAAGA 356
Cdd:cd17352 243 DKPRIGRLY-LYIFTLLILGLSLLAFPLATTYVG--LIVFSVLFGFCSGSYSSLtpviLADLVGLEKLSNAYGLVLLFQG 319
|
330 340 350
....*....|....*....|....*....|...
gi 2519732639 357 LGGFFPPLVMGATYDAAHRN----YFIGLTLLA 385
Cdd:cd17352 320 LAALVGPPIAGLLRDYTGDYdaafYFCGACLLL 352
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
225-372 |
2.33e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 225 LCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTA 304
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2519732639 305 FQPDAehvygPIFLTMAALLGLGSGSVF----GWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDA 372
Cdd:pfam07690 81 FASSL-----WLLLVLRVLQGLGAGALFpaalALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL 147
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
48-192 |
2.47e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 48 QMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSMKSFPLMLVFSFLLGIAGTVf 127
Cdd:cd17478 224 QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPV- 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2519732639 128 avgIPFSAAWYPPARKGFATG-VFGAGMVGTALSAFFTPRLMNLVGYMNTHYIIAALCAVTAIISF 192
Cdd:cd17478 303 ---TVVLAQELLPGNVGLASGlMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-372 |
2.57e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 17 FNLLLI-TFASTVGFWAWTIVGPLAKYyakpeQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVST 95
Cdd:cd06173 1 FRLLWLaQLLSALGDWIFTVALPWLVL-----QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 96 PLV--LLVGLAGSMKSFPLMLVFSFLLGIAGTVFAVGIP------FSAAWYPPARKGFATGVFGAGMVGTALSAFftprL 167
Cdd:cd06173 76 LLAavLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQallpelVPKEQLVRANALNSLATQLARIIGPALGGL----L 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 168 MNLVGYMNTHYIIAALCAVTAIISFLFLRDSPATANREVTPLMPKIIRAFK-------VKSTWQLCFLYSVVFGGFVAFs 240
Cdd:cd06173 152 VALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRylrrsplLRLLLLALALFALLGGALTVL- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 241 nyLPTYLNNIYNFDAEAAGARAAGFAAAAVIARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDaehvyGPIFLTM 320
Cdd:cd06173 231 --LPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS-----LWLLLAA 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2519732639 321 AALLGLGSG----SVFGWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDA 372
Cdd:cd06173 304 LFLLGLAGGlfnvPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
75-199 |
2.80e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 39.79 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 75 GGLTDKYGGR-IMMSLVLAVSTPLVLLVGLAGSMKSFPLMLVFSFLLGIAGTVFAVG-IPFSAAWYPPARKGFATG---- 148
Cdd:cd17337 53 GVLAELFGPRrVMLIGLIIWLVFEVLFLAFGLPSHNYPLMLLTYGLRGFGYPLFAYSfLVWITYRTPAERLGSAVGwfwf 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2519732639 149 VFGAGM--VGTALSAFFTPRLmnlvGYMNTHYIIAALCAVTAIISFLFLRDSP 199
Cdd:cd17337 133 AFTGGLpvLGSYLASFTIPVI----GEIGTLWLSLVFVALGGLIALFLVRDRT 181
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-196 |
4.12e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.07 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 19 LLLITFASTVGFWAWTIVgplakyYAKpEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLV 98
Cdd:COG0738 218 AIFLYVGAEGAIGDWLPL------YLK-DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 99 LLVGLAGSmksFPLMLVFSFLLGIA-GTVFAVGIPFSAAWYPPARKGFATGVFGAGMVGTALSAFFTPRLMNLVGYMNTH 177
Cdd:COG0738 291 LLALLAPG---PWLALIGLALVGLGlSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF 367
|
170
....*....|....*....
gi 2519732639 178 YIIAALCAVTAIISFLFLR 196
Cdd:COG0738 368 LVPLVCYLLILLLALALKR 386
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
47-236 |
4.21e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 4.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 47 EQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGR---IMMSLVLAVstplVLLVGLAGSMKSFPLMLVfsfLLGIA 123
Cdd:cd17335 25 KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRkalLLLSLLAAV----LFFLSLFFVAQIFWLLLL---LVILG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 124 GTVFAVGIPF--SAAWYPPARKGFATG---VFGAgmVGTALSAFFTPRLMN----LVGYMNTHYIIAALCAVTAIISFLF 194
Cdd:cd17335 98 AFFSAPVVPLvdSITLQYLGEERERYGkqrLWGS--IGFGIAALLVGILIDrsstYKNYTIAFYVFAVLMLLALLLALKF 175
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2519732639 195 LRDSPATANREVTPLMPKIIRAFKVkstwqLCFLYSVVFGGF 236
Cdd:cd17335 176 PFRPKHPEPNENTGGLLALLRNPRV-----LAFLLVAFLMGF 212
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-196 |
8.20e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 37.96 E-value: 8.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 69 VGRIPIGGLTDKYGGRIMMSLVLAVstpLVLLVGLAGSMKSFPLMLVFSFLLGIAgtvFAVGIPFSAAWY----PPARKG 144
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTVIIPGLLL---LALGLLLLSFAGSPWMLLLAAVLYGLG---FGLLFPALQALAvdlvPPHRRG 315
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2519732639 145 FATGVFGAGM-VGTALSAFFTPRLMNLVGYMNThYIIAALCAVTAIISFLFLR 196
Cdd:cd17489 316 AANGTFFIFFdLGIGLGGLLLGLVAELFGYRAM-FLLAAVVVLLALVLYIFLL 367
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
274-386 |
8.43e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.02 E-value: 8.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519732639 274 PFGGILADKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLTMAALLGLGSGSVFGWVGRAADPKNVGAVSGVIAA 353
Cdd:cd17355 56 PFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTA 135
|
90 100 110
....*....|....*....|....*....|....
gi 2519732639 354 AGALGGF-FPPLVMGATYDAAHRNYFIGLTLLAV 386
Cdd:cd17355 136 GGGLGSLvFLPLGAALIEAFGWRTALLVLALLAL 169
|
|
| |
