NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2520474137|ref|WP_285400168|]
View 

MULTISPECIES: VOC family protein [unclassified Lysinibacillus]

Protein Classification

VOC family protein( domain architecture ID 10790122)

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms

PubMed:  21820381

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-116 7.81e-22

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


:

Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 83.15  E-value: 7.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137   1 MGRVIGFELNSQEPEKAAEFYAKVFGWEVAA---PHWEYWAVTTGDdnksGINGGIAKGPHD-YPFGTRIQIEVDFIDDA 76
Cdd:COG3324     2 PGTIVWVELPVDDLERAKAFYEEVFGWTFEDdagPGGDYAEFDTDG----GQVGGLMPGAEEpGGPGWLLYFAVDDLDAA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2520474137  77 ISKAKQNGAIVVRDKMEFDEF-YLAYMVDPTGLGFGLIQNK 116
Cdd:COG3324    78 VARVEAAGGTVLRPPTDIPPWgRFAVFRDPEGNRFGLWQPA 118
 
Name Accession Description Interval E-value
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-116 7.81e-22

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 83.15  E-value: 7.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137   1 MGRVIGFELNSQEPEKAAEFYAKVFGWEVAA---PHWEYWAVTTGDdnksGINGGIAKGPHD-YPFGTRIQIEVDFIDDA 76
Cdd:COG3324     2 PGTIVWVELPVDDLERAKAFYEEVFGWTFEDdagPGGDYAEFDTDG----GQVGGLMPGAEEpGGPGWLLYFAVDDLDAA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2520474137  77 ISKAKQNGAIVVRDKMEFDEF-YLAYMVDPTGLGFGLIQNK 116
Cdd:COG3324    78 VARVEAAGGTVLRPPTDIPPWgRFAVFRDPEGNRFGLWQPA 118
SgaA_N_like cd07247
N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth ...
 7-114 1.39e-15

N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.


Pssm-ID: 319911 [Multi-domain]  Cd Length: 114  Bit Score: 66.90  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137   7 FELNSQEPEKAAEFYAKVFGW---EVAAPHWEYWAVTTGDdnksGINGGIAKGP---HDYPFGTRIQIEVDFIDDAISKA 80
Cdd:cd07247     4 FELPTTDLERAKAFYGAVFGWtfeDEGDGGGDYALFTAGG----GAVGGLMRAPeevAGAPPGWLIYFAVDDLDAALARV 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2520474137  81 KQNGAIVVRDKMEFDEF-YLAYMVDPTGLGFGLIQ 114
Cdd:cd07247    80 EAAGGKVVVPPTDIPGGgRFAVFADPEGNRFGLWS 114
Glyoxalase_6 pfam18029
Glyoxalase-like domain; This entry comprises a diverse set of domains related to the ...
 9-110 4.14e-07

Glyoxalase-like domain; This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.


Pssm-ID: 436220  Cd Length: 110  Bit Score: 45.06  E-value: 4.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137   9 LNSQEPEKAAEFYAKVFGWEVAAPHWEYW-AVTTGDDNKSGINGGIAKGPHDYPFGTRIQIE--VDFIDDAISKAKQNGA 85
Cdd:pfam18029   4 LDCADPAALAAFWSAALGWEVVPDDTALPdPDGGGPIGGGGPRLLFQRVPEPKPGKNRVHLDlaVDDLEAAVARLVALGA 83

                          90       100
                  ....*....|....*....|....*
gi 2520474137  86 IVVRDKmEFDEFYLAYMVDPTGLGF 110
Cdd:pfam18029  84 TVLDDG-DDPDGGRWVLADPEGNEF 107
 
Name Accession Description Interval E-value
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-116 7.81e-22

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 83.15  E-value: 7.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137   1 MGRVIGFELNSQEPEKAAEFYAKVFGWEVAA---PHWEYWAVTTGDdnksGINGGIAKGPHD-YPFGTRIQIEVDFIDDA 76
Cdd:COG3324     2 PGTIVWVELPVDDLERAKAFYEEVFGWTFEDdagPGGDYAEFDTDG----GQVGGLMPGAEEpGGPGWLLYFAVDDLDAA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2520474137  77 ISKAKQNGAIVVRDKMEFDEF-YLAYMVDPTGLGFGLIQNK 116
Cdd:COG3324    78 VARVEAAGGTVLRPPTDIPPWgRFAVFRDPEGNRFGLWQPA 118
SgaA_N_like cd07247
N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth ...
 7-114 1.39e-15

N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.


Pssm-ID: 319911 [Multi-domain]  Cd Length: 114  Bit Score: 66.90  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137   7 FELNSQEPEKAAEFYAKVFGW---EVAAPHWEYWAVTTGDdnksGINGGIAKGP---HDYPFGTRIQIEVDFIDDAISKA 80
Cdd:cd07247     4 FELPTTDLERAKAFYGAVFGWtfeDEGDGGGDYALFTAGG----GAVGGLMRAPeevAGAPPGWLIYFAVDDLDAALARV 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2520474137  81 KQNGAIVVRDKMEFDEF-YLAYMVDPTGLGFGLIQ 114
Cdd:cd07247    80 EAAGGKVVVPPTDIPGGgRFAVFADPEGNRFGLWS 114
Glyoxalase_6 pfam18029
Glyoxalase-like domain; This entry comprises a diverse set of domains related to the ...
 9-110 4.14e-07

Glyoxalase-like domain; This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.


Pssm-ID: 436220  Cd Length: 110  Bit Score: 45.06  E-value: 4.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137   9 LNSQEPEKAAEFYAKVFGWEVAAPHWEYW-AVTTGDDNKSGINGGIAKGPHDYPFGTRIQIE--VDFIDDAISKAKQNGA 85
Cdd:pfam18029   4 LDCADPAALAAFWSAALGWEVVPDDTALPdPDGGGPIGGGGPRLLFQRVPEPKPGKNRVHLDlaVDDLEAAVARLVALGA 83

                          90       100
                  ....*....|....*....|....*
gi 2520474137  86 IVVRDKmEFDEFYLAYMVDPTGLGF 110
Cdd:pfam18029  84 TVLDDG-DDPDGGRWVLADPEGNEF 107
PhnB COG2764
Zn-dependent glyoxalase, PhnB family [Energy production and conversion];
9-107 2.11e-04

Zn-dependent glyoxalase, PhnB family [Energy production and conversion];


Pssm-ID: 442048 [Multi-domain]  Cd Length: 118  Bit Score: 37.91  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137   9 LNSQEPEKAAEFYAKVFGWEVAaphweywAVTTGDDNKSG-----INGG---IAKGPHDYPF----GTRIQIEVDFIDDA 76
Cdd:COG2764     6 LVVDDAEEALEFYEDVFGFEVV-------FRMTDPDGKIMhaelrIGGSvlmLSDAPPDSPAaegnGVSLSLYVDDVDAL 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2520474137  77 ISKAKQNGAIVVrdkMEF-DEFY---LAYMVDPTG 107
Cdd:COG2764    79 FARLVAAGATVV---MPLqDTFWgdrFGMVRDPFG 110
VOC cd06587
vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed ...
 7-108 7.88e-04

vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.


Pssm-ID: 319898 [Multi-domain]  Cd Length: 112  Bit Score: 36.35  E-value: 7.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137   7 FELNSQEPEKAAEFYAKVFGWEVAAPHWEYWAVTTGDDNKSGI----NGGIAKGPHDYPFgtRIQIEVDFIDDAISKAKQ 82
Cdd:cd06587     2 VALRVPDLDASVAFYEEVLGFEVVSRNEGGGFAFLRLGPGLRLalleGPEPERPGGGGLF--HLAFEVDDVDEVDERLRE 79

                          90       100
                  ....*....|....*....|....*....
gi 2520474137  83 NGA---IVVRDKMEFDEFYLAYMVDPTGL 108
Cdd:cd06587    80 AGAegeLVAPPVDDPWGGRSFYFRDPDGN 108
GloA COG0346
Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary ...
 14-116 2.13e-03

Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440115 [Multi-domain]  Cd Length: 125  Bit Score: 35.35  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2520474137  14 PEKAAEFYAKVFGWEVAA----PHWEYWAVTTGDDNKSGINggIAKGPHDYPFGTR-----IQIEVDFIDDAISKAKQNG 84
Cdd:COG0346    13 LEASLAFYTDVLGLELVKrtdfGDGGFGHAFLRLGDGTELE--LFEAPGAAPAPGGgglhhLAFRVDDLDAAYARLRAAG 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2520474137  85 AIVVRDKME-FDEFYLAYMVDPTGLGFGLIQNK 116
Cdd:COG0346    91 VEIEGEPRDrAYGYRSAYFRDPDGNLIELVEPP 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH