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Conserved domains on  [gi|2525051036|ref|WP_286952863|]
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MULTISPECIES: DNA methyltransferase [Aminobacterium]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhdJ super family cl43301
DNA modification methylase [Replication, recombination and repair];
12-92 2.45e-24

DNA modification methylase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0863:

Pssm-ID: 440623  Cd Length: 236  Bit Score: 94.22  E-value: 2.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525051036  12 TILCGDALSMLSTFSAESIDCCITSPPYFGMRNYNV-DGQIGLEGTPEKYISRLVNVFQEVFRVLKKTGTVWLNLADSYG 90
Cdd:COG0863     1 RLICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgRREIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYI 80


                  ..
gi 2525051036  91 SY 92
Cdd:COG0863    81 SR 82
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
12-92 2.45e-24

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 94.22  E-value: 2.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525051036  12 TILCGDALSMLSTFSAESIDCCITSPPYFGMRNYNV-DGQIGLEGTPEKYISRLVNVFQEVFRVLKKTGTVWLNLADSYG 90
Cdd:COG0863     1 RLICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgRREIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYI 80


                  ..
gi 2525051036  91 SY 92
Cdd:COG0863    81 SR 82
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 30-104 1.12e-13

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 65.88  E-value: 1.12e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2525051036  30 IDCCITSPPYFGMRNYnvdGQIGLEGTPEKYISRLVNVFQEVFRVLKKTGTVWLNLADSYGSYGGDTYSNFNKRW 104
Cdd:pfam01555   1 VDLIVTDPPYNLGKDY---GQWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIFINIGDSNIKSLKALALEILGIF 72
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
12-83 5.55e-06

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 44.71  E-value: 5.55e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2525051036  12 TILCGDALSMLSTFSAESIDCCITSPPYFGMRNYnvDGQIglEGTPE-KYISRLVNVFQEVFRVLKKTGTVWL 83
Cdd:PRK11524   10 TIIHGDALTELKKIPSESVDLIFADPPYNIGKNF--DGLI--EAWKEdLFIDWLYEWIDECHRVLKKQGTMYI 78
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
12-92 2.45e-24

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 94.22  E-value: 2.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525051036  12 TILCGDALSMLSTFSAESIDCCITSPPYFGMRNYNV-DGQIGLEGTPEKYISRLVNVFQEVFRVLKKTGTVWLNLADSYG 90
Cdd:COG0863     1 RLICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgRREIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYI 80


                  ..
gi 2525051036  91 SY 92
Cdd:COG0863    81 SR 82
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 30-104 1.12e-13

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 65.88  E-value: 1.12e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2525051036  30 IDCCITSPPYFGMRNYnvdGQIGLEGTPEKYISRLVNVFQEVFRVLKKTGTVWLNLADSYGSYGGDTYSNFNKRW 104
Cdd:pfam01555   1 VDLIVTDPPYNLGKDY---GQWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIFINIGDSNIKSLKALALEILGIF 72
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
12-83 5.55e-06

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 44.71  E-value: 5.55e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2525051036  12 TILCGDALSMLSTFSAESIDCCITSPPYFGMRNYnvDGQIglEGTPE-KYISRLVNVFQEVFRVLKKTGTVWL 83
Cdd:PRK11524   10 TIIHGDALTELKKIPSESVDLIFADPPYNIGKNF--DGLI--EAWKEdLFIDWLYEWIDECHRVLKKQGTMYI 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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