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Conserved domains on  [gi|2526979663|ref|WP_288160713|]
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4Fe-4S binding protein [Sharpea azabuensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PorD super family cl34138
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 4-37 7.05e-06

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


The actual alignment was detected with superfamily member COG1144:

Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 38.49  E-value: 7.05e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 2526979663  4 CPQQCI--VEGKPYEIIQEHCLHCGLCYENCPVKAI 37
Cdd:COG1144   42 CPDGAIrvDDGKYYGIDYDYCKGCGICAEVCPVKAI 77
 
Name Accession Description Interval E-value
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 4-37 7.05e-06

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 38.49  E-value: 7.05e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 2526979663  4 CPQQCI--VEGKPYEIIQEHCLHCGLCYENCPVKAI 37
Cdd:COG1144   42 CPDGAIrvDDGKYYGIDYDYCKGCGICAEVCPVKAI 77
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 2-38 2.51e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 38.30  E-value: 2.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2526979663   2 RNCPQQCI--VEGKPyeIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:NF038196  195 KVCPVNNIemEDGKP--VWGHNCTHCLACIHRCPKEAIE 231
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
2-41 1.88e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 36.06  E-value: 1.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2526979663   2 RNCPQQCI-VEGKPYEIIQEHCLHCGLCYENCPVKAIQRRK 41
Cdd:PRK07118  223 KACPAGAItMENNLAVIDQEKCTSCGKCVEKCPTKAIRILN 263
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 1-37 7.31e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 33.91  E-value: 7.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2526979663   1 MRNCPQQCI--VEGKPYEIIQEHCLHCGLCYENCPVKAI 37
Cdd:cd10549    87 VKVCPVDAItlEDELEIVIDKEKCIGCGICAEVCPVNAI 125
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 20-37 3.65e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 32.14  E-value: 3.65e-03
                          10
                  ....*....|....*...
gi 2526979663  20 EHCLHCGLCYENCPVKAI 37
Cdd:NF038196  185 DKCIGCGICAKVCPVNNI 202
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 4-38 7.40e-03

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 31.23  E-value: 7.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2526979663   4 CPQQCI----VEGK-------PYEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:TIGR01971  55 CPADAIrvvpAEGEdgkrrlkFYEINFGRCIFCGLCEEACPTDAIV 100
 
Name Accession Description Interval E-value
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 4-37 7.05e-06

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 38.49  E-value: 7.05e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 2526979663  4 CPQQCI--VEGKPYEIIQEHCLHCGLCYENCPVKAI 37
Cdd:COG1144   42 CPDGAIrvDDGKYYGIDYDYCKGCGICAEVCPVKAI 77
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 2-38 2.51e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 38.30  E-value: 2.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2526979663   2 RNCPQQCI--VEGKPyeIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:NF038196  195 KVCPVNNIemEDGKP--VWGHNCTHCLACIHRCPKEAIE 231
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 1-41 9.21e-05

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 35.40  E-value: 9.21e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 2526979663  1 MRNCPQQCIVEG-KPYEIIQEHCLHCGLCYENCPVKAIQRRK 41
Cdd:COG4231   31 VKVCPADAIEEGdGKAVIDPDLCIGCGSCVQVCPVDAIKLEK 72
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 2-41 1.20e-04

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 35.03  E-value: 1.20e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 2526979663  2 RNCPQQCI-VEGKPYEIIQEHCLHCGLCYENCPVKAIQRRK 41
Cdd:COG2221   25 AVCPTGAIsLDDGKLVIDEEKCIGCGACIRVCPTGAIKGEK 65
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
2-41 1.88e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 36.06  E-value: 1.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2526979663   2 RNCPQQCI-VEGKPYEIIQEHCLHCGLCYENCPVKAIQRRK 41
Cdd:PRK07118  223 KACPAGAItMENNLAVIDQEKCTSCGKCVEKCPTKAIRILN 263
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
1-38 2.40e-04

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 34.32  E-value: 2.40e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 2526979663  1 MRNCPQQCI-VEGKPYEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:COG2768   20 VKVCPVGAIsIEDGKAVIDPEKCIGCGACIEVCPVGAIK 58
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
2-38 3.16e-04

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 35.39  E-value: 3.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2526979663   2 RNCPQQCIVEGKPY-EIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:COG4624   101 RACPVKAIKVDDGKaEIDEEKCISCGQCVAVCPFGAIT 138
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
1-37 3.33e-04

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 35.17  E-value: 3.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2526979663   1 MRNCP-----QQCIV----EGKPyEIIQEHCLHCGLCYENCPVKAI 37
Cdd:PRK13409   22 IKYCPvvrtgEETIEidedDGKP-VISEELCIGCGICVKKCPFDAI 66
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 2-38 3.58e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 33.55  E-value: 3.58e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 2526979663  2 RNCPQQCI--VEGKPYEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:COG1149   21 EVCPEGAIklDDGGAPVVDPDLCTGCGACVGVCPTGAIT 59
PRK13795 PRK13795
hypothetical protein; Provisional
 4-34 4.94e-04

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 34.58  E-value: 4.94e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2526979663   4 CPQQCI--VEGKPY-EIIQEHCLHCGLCYENCPV 34
Cdd:PRK13795  593 CPTGAIriEEGKRKiSVDEEKCIHCGKCTEVCPV 626
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 1-37 7.31e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 33.91  E-value: 7.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2526979663   1 MRNCPQQCI--VEGKPYEIIQEHCLHCGLCYENCPVKAI 37
Cdd:cd10549    87 VKVCPVDAItlEDELEIVIDKEKCIGCGICAEVCPVNAI 125
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 4-38 8.62e-04

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 34.08  E-value: 8.62e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2526979663   4 CPQQCIV---EGKPYEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:PRK12771  522 CPQDAIIklgPGRRYHFDYDKCTGCHICADVCPCGAIE 559
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
2-38 1.39e-03

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 33.50  E-value: 1.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2526979663   2 RNCPQQCIVEGKpyEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:COG0348   220 KVCPMGIDIRKG--EINQSECINCGRCIDACPKDAIR 254
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 1-38 1.92e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 31.64  E-value: 1.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 2526979663  1 MRNCPQQCIV-----EGKPYEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:COG1143   11 VRVCPVDAITiedgePGKVYVIDPDKCIGCGLCVEVCPTGAIS 53
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 4-38 2.21e-03

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 32.83  E-value: 2.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2526979663   4 CP-----QQCIV----EGKPyEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:COG1245    25 CPvnrtgKEAIEidedDGKP-VISEELCIGCGICVKKCPFDAIS 67
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 4-37 3.14e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 31.22  E-value: 3.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 2526979663  4 CPQQCIVEG----KPYEIIQEHCLHCGLCYENCPVKAI 37
Cdd:COG1146   20 CPVDVLELDeegkKALVINPEECIGCGACELVCPVGAI 57
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 8-37 3.49e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 31.98  E-value: 3.49e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2526979663   8 CIVEGKPYEIIQEHCLHCGLCYENCPVKAI 37
Cdd:cd10549    66 YVPKEKEAEIDEEKCIGCGLCVKVCPVDAI 95
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 20-37 3.65e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 32.14  E-value: 3.65e-03
                          10
                  ....*....|....*...
gi 2526979663  20 EHCLHCGLCYENCPVKAI 37
Cdd:NF038196  185 DKCIGCGICAKVCPVNNI 202
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 4-38 7.40e-03

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 31.23  E-value: 7.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2526979663   4 CPQQCI----VEGK-------PYEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:TIGR01971  55 CPADAIrvvpAEGEdgkrrlkFYEINFGRCIFCGLCEEACPTDAIV 100
RDH TIGR02486
reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S ...
 13-41 8.10e-03

reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase (1.97.1.8) which also acts on trichloroethene converting it to dichloroethene.


Pssm-ID: 274158  Cd Length: 314  Bit Score: 31.25  E-value: 8.10e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2526979663  13 KPYEI-IQEHCLHCGLCYENCPVKAIQRRK 41
Cdd:TIGR02486 197 KPIDAgMAKFCETCGKCADECPSGAISKGG 226
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
4-38 8.23e-03

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 31.39  E-value: 8.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2526979663   4 CPQQCIV-----------EGKPYEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:PRK05888   70 CPADAITieaaeredgrrRTTRYDINFGRCIFCGFCEEACPTDAIV 115
NapF COG1145
Ferredoxin [Energy production and conversion];
2-38 9.38e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 31.23  E-value: 9.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2526979663   2 RNCPQQCI--VEGKP-YEIIQEHCLHCGLCYENCPVKAIQ 38
Cdd:COG1145   192 KVCPTGAIrlKDGKPqIVVDPDKCIGCGACVKVCPVGAIS 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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