|
Name |
Accession |
Description |
Interval |
E-value |
| HpaX |
TIGR02332 |
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily ... |
27-432 |
2.45e-173 |
|
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily (pfam07690). Member of this family are found in a number of proteobacterial genomes, but only in the context of having genes for 4-hydroxyphenylacetate (4-HPA) degradation. The protein is characterized by Prieto, et al. ( as 4-hydroxyphenylacetate permease in E. coli, where 3-HPA and 3,4-dihydroxyphenylacetate are shown to competitively inhibit 4-HPA transport and therefore also interact specificially.
Pssm-ID: 131385 [Multi-domain] Cd Length: 412 Bit Score: 492.19 E-value: 2.45e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 27 VMRKVSRHLLGFLFLLFVFSFLDRINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMM 106
Cdd:TIGR02332 1 VIKKLFRRLIIFLFILFIFSFLDRINIGFAGLTMGKDLGLSATMFGLAATLFYAAYVICGIPSNIMLAIIGARRWIAGIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 107 IAWGLASTATLFASGPASLYALRFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDG 186
Cdd:TIGR02332 81 VLWGIASTATMFATGPESLYLLRILVGIAEAGFLPGILLYLTFWFPAYFRARANALFMIAMPVTMALGLILSGYILALDG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 187 HWGLKGWQWLFLLEGMPSVLLGLMVYGYLDDAPHKANWLGTLERQVLARM-----LAAEHKPAAPQAVAQAQTSVLAEMC 261
Cdd:TIGR02332 161 LMALKGWQWLFLLEGFPSVILGVMTWFWLDDSPDKAKWLDEEDKKALKEMidndqLTLEQPEGAFAHAAMPQRSMLREIF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 262 SPTVLKFGIAYFCLVNTLAMVAVWTPLIVKSFNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLS 341
Cdd:TIGR02332 241 TPAIMLYTLAYFCLTNTLSAINIWTPQILQSFNQGSSNIMIGLLAAIPQFCTIFGMIWWSRHSDRLKERKHHTALPYLFA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 342 AAGWLLTAYAGNPVVQLLGVCMASTGAYTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFA 421
Cdd:TIGR02332 321 AAGWLLASATDHNLIQLLGIIMASMGSFSAMAIFWTTPDQSISLQARAIAIAVINATGNIGSALSPFLIGILKDATGSFN 400
|
410
....*....|.
gi 2532376066 422 TGLLYASVLLV 432
Cdd:TIGR02332 401 SGLWFVAALLV 411
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-441 |
2.08e-91 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 281.00 E-value: 2.08e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 49 DRINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYAL 128
Cdd:cd17319 18 DRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 129 RFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldghwGLKGWQWLFLLEGMPSVLLG 208
Cdd:cd17319 98 RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL------LLFGWRWAFIIEGLLGLLLA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 209 LMVYGYLddaphkanwlgtlerqvlarmlaaehkpaapqavaqaqtsvlaemcsPTVLKFGIAYFCLVNTLAMVAVWTPL 288
Cdd:cd17319 172 VLWWFYL-----------------------------------------------RQVWGLALGYFGINYALYGLLTWLPT 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 289 IVKSfNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRL--QERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMAST 366
Cdd:cd17319 205 YLKQ-ARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGF 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2532376066 367 GAYTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVLTL 441
Cdd:cd17319 284 GIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
49-441 |
4.30e-72 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 232.61 E-value: 4.30e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 49 DRINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYAL 128
Cdd:TIGR00893 9 DRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYIL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 129 RFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldghwGLKGWQWLFLLEGMPSVLLG 208
Cdd:TIGR00893 89 RVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWIL------IHFSWQWAFIIEGVLGIIWG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 209 LMVYGYLDDAPHKANWLGTLERQVLARMLAAEHKPAAPQAVAQAqtSVLAEMCSPTVLKFGIAYFCLVNTLAMVAVWTPL 288
Cdd:TIGR00893 163 VLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKY--QIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 289 IVKSFnSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLL-------TAYAGNPVVQLLGV 361
Cdd:TIGR00893 241 YLVQE-RGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVlsllmfaTNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 362 CMASTGAYtAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVLTL 441
Cdd:TIGR00893 320 ALGFFGLG-AGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
49-447 |
1.28e-54 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 185.84 E-value: 1.28e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 49 DRINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYAL 128
Cdd:COG2271 25 DRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 129 RFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDghwglkGWQWLFLLEGMPSVLLG 208
Cdd:COG2271 105 RFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF------GWRAAFLILGLPGLLLA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 209 LMvygylddaphkanwlgtlerqvlarmlaaehkpaapqavaqaqtsvlaemcspTVLKFGIAYFCLVNTLAMVAVWTPL 288
Cdd:COG2271 179 LL-----------------------------------------------------RFWLLALAYFLVYFALYGFLTWLPT 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 289 IVKSFnSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERR-WHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTG 367
Cdd:COG2271 206 YLVEV-RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 368 AYTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHsFATGLLYASVLLVAGAAIVLTLPMARGK 447
Cdd:COG2271 285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
49-407 |
1.98e-51 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 178.60 E-value: 1.98e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 49 DRINIGFAGLTMMQ-DLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYA 127
Cdd:cd17327 20 DKSNISNAAVMGMKeDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 128 LRFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDGHWGLKGWQWLFLLEGMPSVLL 207
Cdd:cd17327 100 LRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLAGWRWLFIIEGLITIII 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 208 GLMVYGYLDDAPHKANWLGTLERQVLARMLAAEHKpaAPQAVAQAQTSVLAEMCSPTVLKFGIAYFCLVNTLAMVAVWTP 287
Cdd:cd17327 180 GLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQT--GKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 288 LIVKSFNSgaSNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTG 367
Cdd:cd17327 258 LILKSLGF--YSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNPPGAYFAAYILGGG 335
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2532376066 368 AYTAMSVFWT-TPDRALSLGARAIGIAVINATGNIGSALNP 407
Cdd:cd17327 336 SYAGFPILLSwISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
53-442 |
2.23e-35 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 135.01 E-value: 2.23e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 53 IGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLV 132
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 133 GVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDghwglkGWQWLFLLEGMPSVLLGLMVY 212
Cdd:COG2223 104 GIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------GWRNAFLILGILLLVVAVLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 213 GYLDDAPHKANWLGTLERQVLARMLAaehkpaapqavaqaqtsvlaemcSPTVLKFGIAYFCLVNTLAMVAVWTPLIVKS 292
Cdd:COG2223 178 LFLRDPPAGAAAAAKASLRDQLEALR-----------------------DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 293 fNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGAYTAM 372
Cdd:COG2223 235 -QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGN 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 373 SVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVLTLP 442
Cdd:COG2223 314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
51-407 |
1.64e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.43 E-value: 1.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 51 INIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRF 130
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 131 LVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldghwGLKGWQWLFLLEGMPSVLLGLM 210
Cdd:pfam07690 94 LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA------SLFGWRAAFLILAILSLLAAVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 211 VYGYLDDAPHKANWLGTLERQVLArmlaaehkpaapqavaqaqtSVLAEMCSPTVLKFGIAYFCLVNTLAMVAVWTPLIV 290
Cdd:pfam07690 168 LLLPRPPPESKRPKPAEEARLSLI--------------------VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 291 KSFnsGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERR--WHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGA 368
Cdd:pfam07690 228 EVL--GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGF 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 2532376066 369 YTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNP 407
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
49-439 |
1.99e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.82 E-value: 1.99e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 49 DRINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYAL 128
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 129 RFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldgHWGLKGWQWLFLLEGMPSVLLG 208
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA----SSLGFGWRAVFLIAAALALLAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 209 LMVYGYLDDAPHKANwlgtlerqvlarmlaaehKPAAPQAVAQAQTSVLAEMCSPTVLKFGIAYFCLVNTLAMVAVWTPL 288
Cdd:cd06174 167 ILLLLVVPDPPESAR------------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 289 IVKSFNsGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGA 368
Cdd:cd06174 229 FLLDLG-GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2532376066 369 YTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVL 439
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
53-405 |
1.03e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 104.29 E-value: 1.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 53 IGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLV 132
Cdd:COG2814 29 VLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 133 GVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDghwglkGWQWLFLLEGMPSVLLGLMVY 212
Cdd:COG2814 109 GLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF------GWRWVFLVNAVLALLALLLLL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 213 GYL-DDAPHKANWLGTLERQVLARmlaaehkpaapqavaqaqtsvlaemcsPTVLKFGIAYFCLVNTLAMVAVWTPLIVK 291
Cdd:COG2814 183 RLLpESRPAARARLRGSLRELLRR---------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 292 SfNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQeRRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGAYTA 371
Cdd:COG2814 236 E-VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG-RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLL 313
|
330 340 350
....*....|....*....|....*....|....
gi 2532376066 372 MSVFWTTPDRALSLGARAIGIAVINATGNIGSAL 405
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-439 |
1.78e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.64 E-value: 1.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 61 MQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGFL 140
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 141 PGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldghwGLKGWQWLFLLEGMPSVLLGLMVYGYLDDAPH 220
Cdd:cd17325 103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA------DALGYRAPFLVCAALALLALVLALLLLPEPRP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 221 KANWLGTLERQVLARMLAAEHKpaapqavaqaqtsvlaemcsPTVLKFGIAYFclVNTLAMVAVWT--PLIVKSFNsGAS 298
Cdd:cd17325 177 PPNKRAVSAARLRSGLRLLLRD--------------------RRLLALFLAIF--VLAFAFGALEPflPLYAAELG-GLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 299 NTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWhIVWPMLLSAAGWLLTAYAGNpVVQLLGVCMASTGAYTAMSVFWTT 378
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL-ILIGLLLSAVALLLLPLATS-FWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2532376066 379 -PDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDfTHSFATGLLYASVLLVAGAAIVL 439
Cdd:cd17325 312 lLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFL 372
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
59-441 |
6.82e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 88.01 E-value: 6.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 59 TMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAG 138
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 139 FLPGMLLYLTYWFPsAYRARANALFMIAMPVTAAIGSALSGLILGLDghwglkGWQWLFLLEGMPSVLLGLmvygyldda 218
Cdd:COG2807 123 GNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL------GWRGALAVWALLALLALL--------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 219 phkanwlgtlerqVLARMLAAEHKPAAPQAVAQAQTSVLAemcSPTVLKFGIAYFCLVNTLAMVAVWTPLIVKSfnSGAS 298
Cdd:COG2807 187 -------------LWLPLLRRRPAAAAAAPAAASLRSLWR---SPLAWLLTLFFGLQSLLYYAVVAWLPPILRD--AGLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 299 NTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLLTAYAGNPVVqLLGVCMASTGAYTAMSVFWTT 378
Cdd:COG2807 249 AATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLP-WLWAVLLGLGQGGLFPLALTL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532376066 379 P-DRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVLTL 441
Cdd:COG2807 328 IgLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
53-439 |
2.49e-16 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 80.36 E-value: 2.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 53 IGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLV 132
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 133 GVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSAlsgLILGLDGHWglkGWQWLFLLEGMPSVLLGLMVY 212
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAA---LLPPLALHY---GWRAAFVVAGLVSILAAVLFW 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 213 GYLDDAPHKAnwlgtlerqvlarmlaaehkpAAPQAVAQAQTSVLAEMCSPTVLKFGIAYFCLVNTLAMVAVWTPLIVKS 292
Cdd:cd17475 169 LFYREPPAAS---------------------AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 293 FnSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGAYTAM 372
Cdd:cd17475 228 H-LGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2532376066 373 SVFWTTPDRAL---SLGARAIGIAV--INATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVL 439
Cdd:cd17475 307 AIGWNGLYLTLvaeSAGPEQAGTALglANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
62-440 |
1.12e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 78.36 E-value: 1.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 62 QDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGFLP 141
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 142 GMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldghwGLKGWQWLFLLEGMPSVLLGLMVYGYLDDAPHK 221
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLG------QLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 222 ANwlgtlerqvlarmlaaehkpaapqAVAQAQTSVLAEMCSPTVLKFGIAYFCLVntLAMVAVWTPLIVK-SFNSGASNT 300
Cdd:cd17324 181 KP------------------------GSLGLLSSLLLLLRNPRLRLAYLITFLLF--GGFFALYTYLAPFlTDVPGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 301 QIGLLAAIPQVCTVIGMIAWGRRSDRLQERRwHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGAYTAMSVFWTtpd 380
Cdd:cd17324 235 AIIGLLLLFGVAGVVGSPLAGRLADRGGRRA-LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT--- 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2532376066 381 RALSLG--ARAIGIAVINATGNIGSALNPVVVGWLkdFTHSFATGLLYASVLLVAGAAIVLT 440
Cdd:cd17324 311 RVLRLApeARGLASSLYLAAYNLGGALGAALGGLV--LDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
49-418 |
1.68e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 77.80 E-value: 1.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 49 DRINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYAL 128
Cdd:TIGR00881 10 VRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 129 RFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLdghwgLKGWQWLFLLEGMPSVLLG 208
Cdd:TIGR00881 90 WALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAE-----LYSWHWVFIVPGIIAIIVS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 209 LMVYGYLDDAPHKANWLGTLERQVLARMLAAEHKPAAPQAVAQAQTSVLAemcSPTVLKFGIAYFCLVNTLAMVAVWTPL 288
Cdd:TIGR00881 165 LICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLL---NKVLWYISLGYVFVYVVRTGILDWSPL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 289 IVKSfNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIV-----WPMLLSAAGWLLTAyAGNPVVQLlgVCM 363
Cdd:TIGR00881 242 YLTQ-EKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLavffmALIIVSLLVYWLNP-AANPLMDL--ICL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 364 ASTG--AYTAMSVFWTTpdrALSLG-ARAIGIA--VINATGNIGSALNPVVVGWLKDFTH 418
Cdd:TIGR00881 318 FALGflVYGPQMLIGVI---ASELApKKAAGTAagFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
53-413 |
9.83e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 75.47 E-value: 9.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 53 IGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLV 132
Cdd:TIGR00895 36 MGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 133 GVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLdghwglKGWQWLFLLEGMPSVLLGLMVY 212
Cdd:TIGR00895 116 GLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV------FGWRSLFYVGGIAPLLLLLLLM 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 213 GYLddaPHKANWLGT-LERQVLARMLA--------AEHKPAAPQAVAQAQTSVLAEMCSPTVLK----FGIAYFCLVNTL 279
Cdd:TIGR00895 190 RFL---PESIDFLVSkRPETVRRIVNAiapqmqaeAQSALPEQKSTQGTKRSVFKALFQGKTARitvlLWLLYFMLLVGV 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 280 AMVAVWTPLIVKsfNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQeRRWHIVWPMLLSAAGWLLTAYAGNPVVQLL 359
Cdd:TIGR00895 267 YFLTNWLPKLMV--ELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG-PRVTALLLLLGAVFAVLVGSTLFSPTLLLL 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2532376066 360 GVCMASTGAYTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWL 413
Cdd:TIGR00895 344 LGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
95-439 |
1.69e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 74.56 E-value: 1.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 95 RIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIG 174
Cdd:cd17316 62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 175 SALSGLILGLDGHWglKGWQWLFLLEGMPSVLLGLMVYgylddaphkanwlgtlerqvlarmlaaehkpaapqavaqaqt 254
Cdd:cd17316 142 ALVASLLIPLLSGD--WGWRILFLIGALPALLALLLRR------------------------------------------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 255 svlaemcspTVLKFGIAYFCLVNTLAMVAVWTPLIVKSfNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLqERRWHI 334
Cdd:cd17316 178 ---------RTLLLILLWFFISFGYYGLTTFLPTYLQT-VLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-GRKKTL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 335 VWPMLLSAAGWLLTAYA--GNPVVQLLGVCMASTGAYTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGW 412
Cdd:cd17316 247 VIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIAL 326
|
330 340
....*....|....*....|....*..
gi 2532376066 413 LKDFTHSFATGLLYASVLLVAGAAIVL 439
Cdd:cd17316 327 LLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
53-445 |
4.92e-14 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 73.00 E-value: 4.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 53 IGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLV 132
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 133 GVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldGHWglkGWQWLFLLEGMPSVLLGLMVY 212
Cdd:cd17365 98 GLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALI---PAF---GWRSVFLLGGVPPLILLPLLR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 213 GylddaphkanwlgtlerqvlarmlaaehkpaapqavaqaqtsvlaemcsptVLKFGIAYFCLVNTLAMVAVWTPLIVKS 292
Cdd:cd17365 172 G---------------------------------------------------TLLLWVTFFMGLLLVYLLNSWLPKLMVE 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 293 fnSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLqERRWHIVWPMLLSAAGWLLTAYAGNPVVqLLGVCMASTGAYT-- 370
Cdd:cd17365 201 --AGYSLSQALTITLLLNIGGVIGSLLLGWLADRF-GPKRVLALFFALGAVSLALLGVSPASLV-LLYVLVFLAGACVng 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2532376066 371 AMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVLTLPMAR 445
Cdd:cd17365 277 AQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
95-442 |
4.89e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 70.29 E-value: 4.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 95 RIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIG 174
Cdd:cd17473 61 RFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVF 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 175 SALSGLILGLdghwglkGWQWLFLLEGMPSVLLGLMvygylddaphkanWLGTLERQVLARMLAAEHKPAapqavaqaqt 254
Cdd:cd17473 141 LLLGGALAEI-------GWRAPFLVYLLALPVLILV-------------LLFLPEPARKSKSAASPGAAT---------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 255 svlaemcSPTVLKFGIAYFCLVNTLAMVAVWT-----PLIVKSFNSGaSNTQIGLLAAIPQVCTVIGMIAWGRRSDRLqE 329
Cdd:cd17473 191 -------AAALPWKRVLPIYFLAFLAMLLFYVipiqlPFLLQERGGG-SAALIGLALAIASLAGAIGALLFGRLKRRL-G 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 330 RRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGAYTAM--SVFWTTpdRALSLGARAIGIAVINATGNIGSALNP 407
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLptLNSWAM--SLVPPELRGRAMGIVTSAFFLGQFLSP 339
|
330 340 350
....*....|....*....|....*....|....*
gi 2532376066 408 VVVGWLKDFTHSFATGLLYASVLLVAGAAIVLTLP 442
Cdd:cd17473 340 LVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-439 |
7.73e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.50 E-value: 7.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 59 TMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAG 138
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 139 FLPGMLLYLTYWFPSAYRAR---ANALFMIAMPVTAAIGSALSGLILGLDghwglkgWQWLFLLEGMPSVLLGLMVYgyl 215
Cdd:COG0738 113 LDVAANPYVAALGPETAASRlnlLHAFFSLGALLGPLLGGLLILLGLSLS-------WHLPYLILAVLLLLLALLFL--- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 216 ddaphkanwlgtlerqvLARMLAAEHKPAAPQAVAQAQTSVLAEmcsPTVLKFGIAYFCLVNTLAMVAVWTPLIVKSfNS 295
Cdd:COG0738 183 -----------------RSKLPEIEEEEEEAAGSAASLKSLLKN---PRLLLGGLAIFLYVGAEGAIGDWLPLYLKD-VL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 296 GASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWhIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGaytaMSVF 375
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL-LRLSALLAAVGLLLALLAPGPWLALIGLALVGLG----LSLM 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 376 WTTpdrALSLGARAIG------IAVINATGNIGSALNPVVVGWLKDfthsfATGLLYASVLLVAGAAIVL 439
Cdd:COG0738 317 FPT---IFSLALDGLGkrtaaaVSAVLIMGIVGGAIGPPLIGFLAD-----AFGLRAAFLVPLVCYLLIL 378
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
60-439 |
1.27e-11 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 65.79 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 60 MMQDLGLSGTQFGFATTLFYIAYIACSIpsnivLARIGARRWIGSMMIAWGLASTATL-----FASGPASLYALRFLVGV 134
Cdd:cd06180 25 MLAELGLSYAQAGWIATANYAGYLVGAL-----LASFLRRRGRARRLIRGGLLLTVLLlaamaLTSGFAALLALRFLAGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 135 TEA-GFLPGMLLYLtYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDGHWGLkGWQWLFLLEGMPSVLLGLMVYG 213
Cdd:cd06180 100 ASAfVFVFGSNLVL-HHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRA-GWLALALLSAVLLLLSFLLLRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 214 YLDDAPHkanwlgtlerqvlarMLAAEHKPAAPQAvaqaqtsvlaemcsptVLKFGIAYFCLVNTLAMVAVWTPLIVKSF 293
Cdd:cd06180 178 GPSAPTE---------------ASAAESAPGLNRP----------------LWRLALAYGLFGFGYIITATFLPLIARET 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 294 nsGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVwPMLLSAAGWLLTAYAGNPVVQLLGvCMASTGAYTAMS 373
Cdd:cd06180 227 --GAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAA-NLLVQAVGVLLPLLSPGPAGLVLS-AVLFGGTFMAIT 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2532376066 374 VFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVL 439
Cdd:cd06180 303 ALVMALARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLAL 368
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
53-321 |
5.27e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 63.29 E-value: 5.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 53 IGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLV 132
Cdd:COG0477 33 VNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQ 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 133 GVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldghwGLKGWQWLFLLEGMPSVLLGLMVY 212
Cdd:COG0477 113 GIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV------AALGWRWIFLINAPLGLLALVLRL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 213 GYLDDAPHKANWLGTLERQVLARMLAAEHKPAAPQAVAQAQTSVLAEMCSPTVLKFGIAYFCLVNTLAMVAVWTPLIVKS 292
Cdd:COG0477 187 RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLL 266
|
250 260
....*....|....*....|....*....
gi 2532376066 293 FNSGASNTQIGLLAAIPQVCTVIGMIAWG 321
Cdd:COG0477 267 LLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
49-439 |
5.65e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 64.18 E-value: 5.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 49 DRINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNiVLARIGARRWIGSMMIA-WGLASTATLFASGPASLYA 127
Cdd:cd17328 14 DRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFG-YLGDRYNRKWILAVGILiWSAATLLSSFAPNFWQLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 128 LRFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDGhwglkGWQWLFLLEGMPSVLL 207
Cdd:cd17328 93 FRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWRWAFRVTGVLGVLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 208 GLMVYGYLDDAPHKanwlgtlerqvlarmlAAEHKPAAPQAVAQAQTSVLAEMCSPTVLKFGIAYFCLVNTLAMVAVWTP 287
Cdd:cd17328 168 AILLLLFVREPPRG----------------AAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 288 -LIVKSFNSGA-SNTQIGL-LAAIPQVCTVIGMIAWGRRSDRLqeRRWHIVWPMLLSAAGWLLTA-------YAGNPVVQ 357
Cdd:cd17328 232 tFFLRAFGVGDlSSADVGLiFGAITCIAGVLGVLLGGILADRL--RRKTPRADPLVCAVGLLAAApflflalVLALSNLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 358 LLGVCMAstGAYTAMSVFWT-TPDRALSL---GARAIGIAVINATGN-IGSALNPVVVGWLKDFTH-----------SFA 421
Cdd:cd17328 310 LAWVLLF--LGEFLLSLNWApVFAILLYVvipTRRSTASAIQILLSHlLGDAGSPYLIGLISDLLRqnkdsplaeaaSLQ 387
|
410
....*....|....*...
gi 2532376066 422 TGLLYASVLLVAGAAIVL 439
Cdd:cd17328 388 YALLLCSFVLVLGGFFFL 405
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
59-441 |
2.15e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.20 E-value: 2.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 59 TMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAG 138
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 139 FLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLIlgldghwGLKGWQWLFLLEGMPSVLLGLMVYGYLDDA 218
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-------AAISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 219 PHKANWLGTLERqvlarmlaaehkpaapqavaqaqTSVLAEMCSPTVLKFGIAYFCLVNTLAMVAVWTPLIVKsFNSGAS 298
Cdd:cd17474 177 KEKAKSSSATKL-----------------------RDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE-LLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 299 NTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGAYTAMSVFWTT 378
Cdd:cd17474 233 PIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2532376066 379 PDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFtHSFATGLLYASVLLVAGAAIVLTL 441
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI-FGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
60-441 |
2.48e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 61.90 E-value: 2.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 60 MMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARR--WIGSMMIAWGLASTAtlFASGPASLYALRFLVGVTEA 137
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRvmLLGLLLLAAGLVLLA--LATSLWQLYLLWGLLGGGGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 138 GFL-PGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDGhwglkgWQWLFLLEGMPSVLLGLMVYgyld 216
Cdd:cd17355 107 GTLaAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG------WRTALLVLALLALLVLVPVL---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 217 daphkanwlgtlerQVLARMLAAEHKPAAPQAVAQAQTSVLAEMC--SPTVLKFGIAYFCLVNTLAMVAVWTPLIVksfN 294
Cdd:cd17355 177 --------------LLLRRRPADLALRAYDDASPASPGSTLKEALrsASFWLLALAFFLCGFAVVGLIVHLVPYLA---D 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 295 SGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLqERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCM---ASTGAYTA 371
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRY-SPRRLLAASYALRALGLALLLLLPFPPLALLLFAAlfgLGWGATVP 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 372 MSVFWTTPDRALSLGARAIGIavINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVLTL 441
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGL--VFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-441 |
2.62e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.84 E-value: 2.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 62 QDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGFLP 141
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 142 GMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDGHWglkgwqWLFLLeGMPSVLLGLMVYGYLDDAPHK 221
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFA------VLFIV-AAVLALLALLLVFLVKDPPPV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 222 ANWLGTLERQVLARMLaaehkpaapqavaqaqtsvlaemcSPTVLKFGIAYFCLVNTLAMVAVWTPLIVKSFNSgasnTQ 301
Cdd:cd17489 177 AAEEAEAGTRAFRRLV------------------------EKKVLPPALILFLASIAYGAISTFLPLYAAERGI----SN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 302 IGLLAAIPQVCTVIGMIAWGRRSDRLQeRRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTG------AYTAMSVF 375
Cdd:cd17489 229 AGLFFTVYAIALLLSRPFSGKLSDRKG-PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfgllfpALQALAVD 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2532376066 376 WTTPDRalslgaRAIGIAVINATGNIGSALNPVVVGWLKDFThSFATGLLYASVLLVAGAAIVLTL 441
Cdd:cd17489 308 LVPPHR------RGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
57-444 |
2.18e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.80 E-value: 2.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 57 GLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRW-IGSMMIAWGLASTATLFASGPASLYALRFLVGVT 135
Cdd:cd17341 22 GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 136 EAGFLPGMLlYLTYWFPSAYRARANALF----MIAMPVTAAIGSALSGLILGLDGHwglKGWQWLFLLEGMPSVLLGLMV 211
Cdd:cd17341 102 GANFASGQP-WASFWFPKEKIGGAAGGIagagNMGVAVSQLLAPLIAGAIVFDGGF---VGWRNAFFVPGILLAIAAVLV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 212 YGYLDDAPHKANWlgtlERQVLARMLAAehkpaapqavaqAQTSVLAEMCSPTVLKFGIayfclvnTLAMVAVWTPLIVK 291
Cdd:cd17341 178 LLFGDDLPTGKAS----ALEFLKVQLAV------------LKNYRTWILSLLYGVTFGS-------FVGFSNVLPTYFKT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 292 SFnsGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLL-----TAYAGNPVVQLLGVCMAST 366
Cdd:cd17341 235 RF--GLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLslslpTSGTNLVLFLALFVALGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532376066 367 GAYTAMSVFWTTPDRALSLGARAIGIavINATGNIGSALNPVVVGWLKDFTHSFATGLlyasvLLVAGAAIVLTLPMA 444
Cdd:cd17341 313 AGAGNGSVFRMVPFIFRRELGAVTGL--VGAIGGLGGFFLPLLFGSSALMTGSGVGAF-----SLFGVLAVACTLLVW 383
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
59-442 |
2.40e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 58.85 E-value: 2.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 59 TMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAG 138
Cdd:cd17371 24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 139 -FLPGMLLYLTYWfPSAYRARANALFMIAMPVTAAIGSALSGLILGLDGhwGLKGWQWLFLLEGMPSvLLGLMVYGYLDD 217
Cdd:cd17371 104 eWAAGAALMAEYV-PARHRGKALGYVQSGWAVGWLLATLLAALLFPLLP--PEIAWRVLFLLGALPA-LLVLFIRRFVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 218 APhkanwlgtlerqvlaRMLAAEHKPAAPQAVAQAQTSVLAEMCSPTVLKFGIAYFCLVnTLAMVAVWTPLIVKSFNSGA 297
Cdd:cd17371 180 PP---------------QWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALG-GYYGITTWLPSYLTGERGLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 298 SNTQIGLLAAIpQVCTVIGMIAWGRRSDRLQeRRWHIVWPMLLSAAGWLLTAYA----GNPVVQLLGVCMASTGAYTAMS 373
Cdd:cd17371 244 FEGSAGYLVVT-ILGGFLGYLAGGFLADRIG-RRNNFALFALGSAISILLYFFLplspTLILILGFPLGFFASGPFSGMG 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 374 VFWTtpdRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDfTHSFATGL-LYASVLLVAGAAIVLTLP 442
Cdd:cd17371 322 AYLT---ELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLAT-SGSLGTAIaVFAAVYYIAGLVLALLLP 387
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
49-437 |
6.64e-09 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 57.18 E-value: 6.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 49 DRINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLAS--TATLFASGPASLY 126
Cdd:cd17380 14 DRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATllTPLLAYSSLPLLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 127 ALRFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPvtaaIGSALSGLILGLDGHWGlkGWQWLFLLEGMPSVL 206
Cdd:cd17380 94 LSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSY----LGTLLGGLIGPLLLEYY--GWPSVFYFFGLLGLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 207 LGLMVYGYLddaphKANWlgtlerqvlarmlaaehkpaapqavaqaqtSVLaemcsptvlkfgIAYFCLVNTLAMVAVWT 286
Cdd:cd17380 168 WALVWLIYL-----PPVW------------------------------AII------------VAHFCMNWGFYILLSWL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 287 PLIvksFNSG-ASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVW--------PMLLSAAGWLLTAYAGNPVVQ 357
Cdd:cd17380 201 PTY---FHEVlVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSvrklmqsiGFLGPALFLLLLSHTDSFSLA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 358 LLGVCMASTGAYTAMSVFWTTPdraLSLGARAIGI--AVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGA 435
Cdd:cd17380 278 LLCMSVALGLSAFSSSGVLVNH---QDIAPNYAGIvfGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGA 354
|
..
gi 2532376066 436 AI 437
Cdd:cd17380 355 VV 356
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
50-219 |
1.13e-08 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 56.65 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 50 RINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALR 129
Cdd:cd17488 19 RKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 130 FLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMpvtaAIGSALSGLILGLDGHWGlkGWQWLFLLEGMPSVLLGL 209
Cdd:cd17488 99 TLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSH----NIGGALIPILTGFAALTY--GWRAGMYVPGIIAILMGI 172
|
170
....*....|
gi 2532376066 210 MVYGYLDDAP 219
Cdd:cd17488 173 VLCWRLRDRP 182
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
60-439 |
5.74e-08 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 54.30 E-value: 5.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 60 MMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARR--WIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEA 137
Cdd:pfam06779 19 MIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRLrpALLAGLLATVLLLLAMAATSSFWAVLLIRFLAGVASA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 138 GflpGMLLYLTYWFPSAYRARANALFMIAMpVTAAIGSALSGLILGLDGHWGLKGwQWLFLLEGMPSVLLGLMVYGYLDD 217
Cdd:pfam06779 99 A---VMIFGSSLILGHATAARRAFVGALLF-AGVGIGIALSGLLVPLGLQLGLGG-SSLWYGAGVLSAVLTLAVFPLLPR 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 218 APHKANWLGTLERQVLARMLAaehkpaapqavaqaqtsvlaemcsptVLKFGIAYFCLVNTLAMVAVWTPLIVKSFNSGA 297
Cdd:pfam06779 174 RAPRHASAPAPAAKPLQRSLP--------------------------LWILTLAYGLAGFGYIITATFLPAMARDGFGGP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 298 SNTQigLLAAIPQVCTVIGMIAWGRRSDRLQERRWhIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMAStGAYTAMSVFWT 377
Cdd:pfam06779 228 AAAA--LFWSLFGLAAALGVLVWLRAAKRWGTRPA-LTAALLIQALGVLLSLLSPSPAGLAVSSLLFG-GTFMAITSLVM 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2532376066 378 TPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAAIVL 439
Cdd:pfam06779 304 QLARELAPPAPRRLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIVL 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
156-448 |
8.16e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 8.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 156 RARANALFMIAMPVTAAIGSALSGLILGLDGHWGLKGWQWLFLLEGMPSVLLGLMVYGYLDDAPHKANWLGTLeRQVLAR 235
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSL-KESLKA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 236 MLAaehkpaapqavaqaqtsvlaemcSPTVLKFGIAYFCLVNTLAMVAVWTPLIVKsFNSGASNTQIGLLAAIPQVCTVI 315
Cdd:COG2211 224 LLK-----------------------NRPFLLLLLAYLLFFLALALVAALLLYYFK-YVLGLSAALVGLLLALYFLAALL 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 316 GMIAWGRRSDRLQERRWHIVWpMLLSAAGWLLTAYAG--NPVVQLLGVCMASTGAYTAMSVFW-----TTPDRALSLGAR 388
Cdd:COG2211 280 GAPLWPRLAKRFGKKKAFIIG-LLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWamladVVDYDEWKTGRR 358
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2532376066 389 AIGI--AVINATGNIGSALNPVVVGWLKDF---------THSFATGL-----LYASVLLVAGAAIVLTLPMARGKE 448
Cdd:COG2211 359 REGLyfGIFTFAIKLGQALAGALAGLLLALfgyvagaaqSPSALTGIrllffLLPAVLLLLAALLLLFYPLTRERH 434
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
264-442 |
2.21e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.67 E-value: 2.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 264 TVLKFGIAYFCLVNTLAMVAVWTPLIVKSFnsGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLqERRWHIVWPMLLSAA 343
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADL--GASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 344 GWLLTAYAGNPVVQLLGVCMASTGAYTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATG 423
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*....
gi 2532376066 424 LLYASVLLVAGAAIVLTLP 442
Cdd:COG2814 168 LVNAVLALLALLLLLRLLP 186
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
56-199 |
5.39e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 5.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 56 AGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVT 135
Cdd:cd17321 18 ALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIG 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532376066 136 EAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDghwglkGWQWLFLL 199
Cdd:cd17321 98 AAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF------GWRWIFLI 155
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
62-441 |
2.46e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.53 E-value: 2.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 62 QDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARR-WIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGFL 140
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKlFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 141 PGMLLYLTYwFPSAYRARANALFMIAMPVTAAIGSALSGLIlglDGHWGLKGWQWLFLLEGMPSVLLGLMVYGYLDDAPH 220
Cdd:cd17490 104 SFTVLYASY-FPPDEAAKAMGLINLVNNLGQLIAFLIGGLI---AEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 221 KANWLGTLERQVLARMLaaehkpaapqavaqAQTSVLAemcsptVLKFGIAYfclvntlAMVAVWTPLIVKSFnsGASNT 300
Cdd:cd17490 180 VLTELKELLSVLKDKKL--------------LFFSLLA------ILQQMITF-------STTFGFTPLIAKQL--GASSF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 301 QIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGAYTAMSVFWTTPD 380
Cdd:cd17490 231 QLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSI 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2532376066 381 RALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFThSFATGLLYASVLLVAGAAIVLTL 441
Cdd:cd17490 311 EGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAF-GLQTGFFVIGVIALLAAILSLAY 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
58-215 |
3.31e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.11 E-value: 3.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 58 LTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEA 137
Cdd:cd17325 224 LYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLG 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532376066 138 GFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLIlgldghWGLKGWQWLFLLEGMPSVLLGLMVYGYL 215
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL------YDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
78-201 |
3.79e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.77 E-value: 3.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 78 FYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFAS--GPASLYALRFLVGVTEAGFLPGMLLYLTYWFPSAY 155
Cdd:cd17318 65 FFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLE 144
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2532376066 156 RARanaLFMIAMpVTAAIGSALSGLILGLDGHWGlkGWQWLFLLEG 201
Cdd:cd17318 145 RSR---LTSIAY-SGSQFGTVIAMPLSGFLCESL--GWPSIFYIFG 184
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
53-445 |
4.81e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 48.42 E-value: 4.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 53 IGFAGLTMMQDLGLSGTQFGfattLFYIAYIACSIPSNIV---LA-RIGARRWIGSMMIAWGLASTATLFASGPASLYAL 128
Cdd:PRK11551 34 AGVAAPRMAQEFGLDVAQMG----WAFSAGILGLLPGALLggrLAdRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 129 RFLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALsGLILGLDGhwglkGWQWLFLLEGMPSVLLG 208
Cdd:PRK11551 110 RLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVI-GVLAAGDA-----AWRHIFYVGGVGPLLLV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 209 LmvygylddaphkanwlgtlerqVLARMLAAEHKPAAPQAVAQAQTSVLAEMCSP----TVLKFGIAYFCLVNTLAMVAV 284
Cdd:PRK11551 184 P----------------------LLMRWLPESRAFAQAAGAGKQRAPVLRALFGEgratATLLLWISYFFTLIVLYFLLN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 285 WTPLIVKSfnSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLqeRRWHIVWPMLLSAAGWLLT-AYAGNPVVQLLGVCM 363
Cdd:PRK11551 242 WLPSLLVG--QGLSRSQAGLVQIAFNIGGALGSLLIGALMDRL--RPRRVVLLIYAGILASLAAlAAAPSFAGMLLAGFA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 364 ASTGAYTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSfATGLLYASVLLVAGAAIVLTLPM 443
Cdd:PRK11551 318 AGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRS-TVGVIGASIPVILVAALAALLLV 396
|
..
gi 2532376066 444 AR 445
Cdd:PRK11551 397 SR 398
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
50-219 |
1.11e-05 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 47.40 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 50 RINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALR 129
Cdd:PRK11663 39 RKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLW 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 130 FLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVtaaiGSALSGLILG-LDGHWglkGWQWLFLLEGMPSVLLG 208
Cdd:PRK11663 119 VLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNV----GGALIPLVVGaIALHY---GWRYGMMIAGIIAIVVG 191
|
170
....*....|.
gi 2532376066 209 LMVYGYLDDAP 219
Cdd:PRK11663 192 LFLCWRLRDKP 202
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
60-440 |
3.19e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 46.03 E-value: 3.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 60 MMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAwGLASTATLFASGPASLYALRFLVGVTEAG- 138
Cdd:cd17339 25 IRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLL-LAAGILLRSLGGIALLFLGTALAGAGIAVg 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 139 --FLPGMllyLTYWFPSaYRARANALFMIAMPVTAAIGSALSGLILgldgHWGLKGWQWLFLLEGMPSVLLGLMvygyld 216
Cdd:cd17339 104 nvLLPSL---IKRDFPR-RVGLMTGLYTTSMNLGAALASGLSVPLA----QALGGGWRGALAIWALPALLALLI------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 217 daphkanWLGTLERQVlarmlaAEHKPAAPQAVAQAQTSVLAEMCsptvlkfgIAYFCLVNTLAMVAV-WTPLIVKsfNS 295
Cdd:cd17339 170 -------WLPQLRRRK------RAAAAAAPLTKISVWRSPLAWQV--------TLFMGLQSLLFYTLMaWLPTILI--DA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 296 GASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTG------AY 369
Cdd:cd17339 227 GLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLGLGGgaafslAL 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2532376066 370 TAMSVFWTTPDRALSLGARAIGIavinatGNIGSALNPVVVGWLKDFTHSFATGLLyasVLLVAGAAIVLT 440
Cdd:cd17339 307 TLISLRSSDPAEAAALSGMAQSV------GYLLAALGPLLFGVLHDLTGSWTAPLV---LLLALTVLQLVA 368
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
62-219 |
3.42e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 45.76 E-value: 3.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 62 QDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPAS-LYALRFLVGVTEAGFL 140
Cdd:TIGR00886 30 DDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSvLLLIRLFIGIAGGSFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 141 PGMLLyLTYWFPSAYRARANALFM----IAMPVTAAIGSALSGLILGLDGHWGLKGWQWLFLL-EGMPSVLLGLMVYGYL 215
Cdd:TIGR00886 110 SCMPW-ISFFFPKKIQGTALGLAAgwgnMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIvPAGILLLPALLIFFVG 188
|
....
gi 2532376066 216 DDAP 219
Cdd:TIGR00886 189 ADTP 192
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
50-441 |
6.12e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.96 E-value: 6.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 50 RINIGFAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIawgLASTATLFASGPASLYALR 129
Cdd:cd17312 19 RKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLL---LSALANIFMGFSTSLWFFA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 130 FLVG----VTEAGFLPGMLLyLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldghwGLKGWQWLFLLEGMPSV 205
Cdd:cd17312 96 VLWGlnglFQSMGWPPCVKL-LGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA------SYYGWRAAFLVPGIVGL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 206 LLGLMVYGYLDDAPhkanwlgtlerqvlarmlaaehkpaapqavaqaqtsvlaemcsPTVLKFGIAYFCLVNTLAMVAVW 285
Cdd:cd17312 169 VVAIILFFFLRDSP-------------------------------------------PYVWVLSLAYAFVYIVRYACLDW 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 286 TPLI---VKSFNSGASNTQIGLLAaipqVCTVIGMIAWGRRSDRLQERRWHIvwPMLLSAAGWLLTAYAGNPVVQ---LL 359
Cdd:cd17312 206 GPLYlyeVKGYSLIDAGWFSSLYE----VGGIAGTILAGLLSDKLFGGRRAP--IAVIYMLLMTLSLALFWFFPHnklLS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 360 GVCMASTGAYTAMSV-FWTTPDRALSLGARAIGIA--VINATGNIGSALNPVVVGWLKDFTHSFATGLLYASVLLVAGAA 436
Cdd:cd17312 280 IVLLFLIGFFVGGPInLIGGAAAQDIGRKEAAGTAtgFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLL 359
|
....*
gi 2532376066 437 IVLTL 441
Cdd:cd17312 360 LLSLW 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
269-441 |
6.30e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 6.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 269 GIAYFCLVNTLAMVAVWTPLIVKSFnsGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWhIVWPMLLSAAGWLLT 348
Cdd:COG2271 16 FLAYFLNYLDRSNLSVAAPPLQADL--GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV-LAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 349 AYAGNP-------VVQLLGVCMASTGAYTAMSVfWTTPDRalslgaRAIGIAVINATGNIGSALNPVVVGWLKDFTHSFA 421
Cdd:COG2271 93 GFATSFwqllllrFLLGLGEAGFFPAALKLIAE-WFPPKE------RGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180
....*....|....*....|
gi 2532376066 422 TGLLYASVLLVAGAAIVLTL 441
Cdd:COG2271 166 AFLILGLPGLLLALLRFWLL 185
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
61-216 |
7.74e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.88 E-value: 7.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 61 MQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGFL 140
Cdd:cd17335 225 LQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVW 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2532376066 141 PGMLLYLTYWFPSAYRARANALF-MIAMPVTAAIGSALSGLIlgldghWGLKGWQWLFLLEGMPSvLLGLMVYGYLD 216
Cdd:cd17335 305 AAAVSYASAAAPPGLRATAQGLLqGLYFGLGGGLGSLIGGYL------YEAFGARTTFRFFAIAA-LAGLLAFFLIQ 374
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
50-219 |
1.06e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 44.54 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 50 RINIGFAGLTMMQDLGLSGTQFGFATTLFYIAY-IACSIPSNIVlARIGARRWIGSMMIAWGLASTATLFASG-PASLYA 127
Cdd:cd17345 19 RNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYgLSKFVMGNLS-DRSNPKRFLAIGLILSAIINILIGFVPSaTSSVGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 128 LRFLVGVTeaGFLPGML-----LYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDGHwglKGWQWLFLLEGM 202
Cdd:cd17345 98 MFILLFLN--GWFQGMGwppsgRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGD---GWWRGAFIFPAI 172
|
170
....*....|....*..
gi 2532376066 203 PSVLLGLMVYGYLDDAP 219
Cdd:cd17345 173 IAIIVAVIVLFLGKDTP 189
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
280-445 |
1.71e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.70 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 280 AMVAVWTPLIVKSFnsGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLqERRWHIVWPMLLSAAGWLLTAYAGNPVVQLL 359
Cdd:cd17478 13 GFLPALLPLLIAKL--GLSYAQAGLLVSVFSITSSLLQPLFGYLADRK-PRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 360 GVCMASTG--AY--TAMSVFwttpdRALSLGARAIGIAVINATGNIGSALNPVVVGWLkdfthsFATGLLYASVLLVAGA 435
Cdd:cd17478 90 LVALAGIGsaAFhpEGARLA-----SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL------VALFGGLGLLILLIIP 158
|
170
....*....|
gi 2532376066 436 AIVLTLPMAR 445
Cdd:cd17478 159 GLAVALLLLR 168
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
268-445 |
2.57e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.95 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 268 FGIAYFCLVNTLAMVAVWTPLIVKSFNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWHIVwPMLLSAAGWLL 347
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLL-SLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 348 TAYAGNPVVQLL-----GVCMASTGAYTAMSVFWTTPDralslgARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFAT 422
Cdd:cd17330 81 LGLSRNLWLLFLarfldGLTGGNVSVAQAYIADITDEE------ERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALP 154
|
170 180
....*....|....*....|...
gi 2532376066 423 GLLYASVLLVAGAAIVLTLPMAR 445
Cdd:cd17330 155 FLVAAALALLNLVLVLFFLPPLR 177
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
55-441 |
5.40e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 5.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 55 FAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGV 134
Cdd:cd17329 21 FMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 135 TEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDGhwglkgwQWLFLLEGMPSVLLGLMVYGY 214
Cdd:cd17329 101 GGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-------RLLFLAAAVLFLLAALVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 215 LD-DAPHKANWLGTLERQVLARMLAAehkpaapqavaqaqtsvlaemcsPTVLKFGIAYFCLVNTLAMVAVWTPLIVKSF 293
Cdd:cd17329 174 LPeTRPKRRAAEKTEILRGYKIVLRD-----------------------RAFLLFLLASFLISLIYFQLESTLPVYVVEI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 294 NsGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWhIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGAYTAMS 373
Cdd:cd17329 231 L-GLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKI-LMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFP 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532376066 374 VFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFtHSFATGLLYASVLLVAGAAIVLTL 441
Cdd:cd17329 309 AVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL-LGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
61-184 |
5.48e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 5.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 61 MQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGFL 140
Cdd:cd17477 23 LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLF 102
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2532376066 141 PGMLLYLTYWFPSAYRARANALFMIAMpvtaAIGSALSGLILGL 184
Cdd:cd17477 103 VVSESWLNALATNENRGRVLGLYSTVL----GLGFALGPLLLAL 142
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
270-442 |
5.83e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 5.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 270 IAYFCLVNTLAMVAVWTPLIVKSfNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWhIVWPMLLSAAGWLLTA 349
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV-LLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 350 YAGNPVVQLLGVCMASTGAYTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATGLLYASV 429
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|...
gi 2532376066 430 LLVAGAAIVLTLP 442
Cdd:pfam07690 161 SLLAAVLLLLPRP 173
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
51-441 |
6.71e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.92 E-value: 6.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 51 INIGFAGLTMM---QDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYA 127
Cdd:cd17333 10 LTDALLGILGPsleEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 128 LRFLVGVTEAGFLPGMLLYLTYWFPSAYRARanalfMIAMPVTAAIGSALSGLILGLDGHWGLkGWQWLFLLEGMPSVLL 207
Cdd:cd17333 90 LMFLAGLGAGILDTGANTFVGALFEESSATR-----LNVLHGFFGLGALIGPLIATSLLTSEL-SWSWAYLIIGLIYLLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 208 GLMVYgylddaphkanwlgtlerqvLARMLAAEHKPAAPQAVAQAQTSVLAEMCSPTVLKFGIAYFCLVNTLAMVAVWTP 287
Cdd:cd17333 164 AILIL--------------------LTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 288 LIVKSfNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWhIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTG 367
Cdd:cd17333 224 SYLVE-KKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTL-LVLSGSGALLGLLILLLAPTLVVGLVATALLGLF 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 368 aytaMSVFWTTpdrALSLGARAI------GIAVINATGNIGSALNPVVVGWLKDfthsfATGLLYASVLLVAGAAIVLTL 441
Cdd:cd17333 302 ----MAALFPT---ILSLGISNLpyakgkGTSVLLAAGSIGGAIIPFIMGFIAE-----AVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
61-212 |
7.95e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 7.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 61 MQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGFL 140
Cdd:cd06173 236 KEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFN 315
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2532376066 141 PGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDghwglkGWQWLFLLEGMPSVLLGLMVY 212
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL------GLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
60-439 |
1.29e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.00 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 60 MMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAGF 139
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 140 LPGMLLYLTYwFPSAYRARANALFMIAMPVTAAIGSALSGLILGLdghWGLKGWQWLFLLegmPSVLLGLMVYGYLDDAP 219
Cdd:cd17478 102 HPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVAL---FGGLGLLILLII---PGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 220 HKAnwlgtlerqvlarmlaaehkpaAPQAVAQAQTSVLAEMCSPTVLKFGIAYFclvNTLAMVAVWTPLIVKSFNSGASN 299
Cdd:cd17478 175 PEA----------------------KKAAAKSSARSTLKGVWRALLLLLIIVFL---RSWVLSSLTTFLPFYLVQRGYSL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 300 TQIGLLAAIPQVCTVIGMIAWGRRSDRLQERRWhIVWPMLLSAAGWLLTAYA-GNPVVQLLGVCMASTGAYTAMSVFWtt 378
Cdd:cd17478 230 VFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRV-IIASLLLAAPFLLLFLLTpGIWSYILLVLAGFLLFASFPVTVVL-- 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2532376066 379 pdrALSLGARAIGIA--VINATGNIGSALNPVVVGWLKDfTHSFATGLLYASVLLVAGAAIVL 439
Cdd:cd17478 307 ---AQELLPGNVGLAsgLMMGLSFGLGGIGAPVLGALAD-AFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
59-199 |
2.19e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 59 TMMQDLGLSGTQFGFATTLFYIAyIACSIP-SNIVLARIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEA 137
Cdd:cd17503 21 TIMGDLGASLDTVQWVITSYLLA-LAIMIPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGG 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2532376066 138 GFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILgldghwGLKGWQWLFLL 199
Cdd:cd17503 100 VLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLT------DNLSWRWIFYI 155
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
63-220 |
2.34e-03 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 40.29 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 63 DLGLSGTQFGFATtlfyIAYIACSIPSNIVLA----RIGARRWIGSMMIAWGLASTATLFASGPASLYALRFLVGVTEAG 138
Cdd:PLN00028 65 NLNLTKSDIGNAG----IASVSGSIFSRLAMGpvcdLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLAT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 139 FLPGMllyltYWFPSAYRAR----ANALfmiampvtAA----IGSALSGLILGL-------DGHWGLKGWQWLFLLEGMP 203
Cdd:PLN00028 141 FVSCQ-----YWMSTMFNGKivgtANGI--------AAgwgnLGGGVTQLLMPLvfplikdAGAPSFTAWRIAFFVPGLL 207
|
170
....*....|....*..
gi 2532376066 204 SVLLGLMVYGYLDDAPH 220
Cdd:PLN00028 208 HIIMGILVLTLGQDLPD 224
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
64-186 |
5.21e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.12 E-value: 5.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 64 LGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFA--SGPASLYALRFLVGVTEAGFLP 141
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILV 338
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2532376066 142 GMLLYLT-------YWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDG 186
Cdd:COG2211 339 LPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
55-441 |
6.34e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 6.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 55 FAGLTMMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRW-----IGSMMIAWGLASTATLFASGPASLYALR 129
Cdd:cd06173 20 VALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 130 FLVGVTEAGFLPGMLLYLTYWFPSAYRARANALFMIAMPVTAAIGSALSGLILGLDGHWglkgwqWLFLLEGMPSVLLGL 209
Cdd:cd06173 100 FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG------GAFAINALSFLLSAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 210 MVygylddaphkanwlgtlerqVLARMLAAEHKPAAPQAVAQAQTSVLAEMCSPTVLKFGIAYFCLVNTL-AMVAVWTPL 288
Cdd:cd06173 174 LL--------------------LFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLgGALTVLLPL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 289 IVKSfNSGASNTQIGLLAAIPQVCTVIGMIAWGRRSDRLqERRWHIVWPMLLSAAGWLLTAYAGNPVVQLLGVCMASTGA 368
Cdd:cd06173 234 LAKE-VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR-RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAG 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2532376066 369 YTAMSVFWTTPDRALSLGARAIGIAVINATGNIGSALNPVVVGWLKDFTHSFATgLLYASVLLVAGAAIVLTL 441
Cdd:cd06173 312 GLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV-FLLAGALLLLAALLLLLL 383
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
61-212 |
7.24e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 7.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 61 MQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGaRRWIGSMMIAWGLASTATLFASGPASLYAL----RFLVGVTE 136
Cdd:cd17357 41 NLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFG-RKNGLLISNALLVVSSLLMFLSKSAKSPELlifgRFLVGIAC 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2532376066 137 AGFLPGMLLYLTYWFPSAYRARANalFMIAMPVTAAIgsaLSGLILGLDGHWGLK-GWQWLFLLEGMPSVLLGLMVY 212
Cdd:cd17357 120 GLSTGFVPMYLQEISPSELRGALG--SLTQIGVTLGI---LLGQVFGLPSVLGTEtLWPYLLFFPGIPALLQLAALP 191
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
60-209 |
9.30e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 37.97 E-value: 9.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532376066 60 MMQDLGLSGTQFGFATTLFYIAYIACSIPSNIVLARIGARRWIGSMMIAWGLASTATLFA--SGPASLYALRFLVGVTEA 137
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVG 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532376066 138 GFLPGMLLYLTYWFPSAYRARANALFMiampVTAAIGSALSGLILG--LDGHWGLKGWQWLFLLEGMPSVLLGL 209
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSY----NLGRLGGGGAPPLIAllLASTGGTGVPALILALLAIVALIVAL 353
|
|
| |
