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Conserved domains on  [gi|2532542707|ref|WP_290033309|]
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MFS transporter [Ligilactobacillus cholophilus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
28-434 2.77e-143

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17345:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 411  Bit Score: 415.49  E-value: 2.77e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  28 QTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAV 107
Cdd:cd17345     1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLG----STQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQF-ATFLFT 182
Cdd:cd17345    81 INILIGfvpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLgLAIFGD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 183 DSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLDTGEENNKEvssLSLPQIFMKYILNNKMVWAIT 262
Cdd:cd17345   161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQE---LSAWEIFVKYVLKNKLLWYIA 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 263 LTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL-KNYRAIVCIGCVVGLIACLTAY 340
Cdd:cd17345   238 IANVFVYLVRYGILDWAPTYLSEvKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfKGRRAPTGIIFMILVIVALIVY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 341 FFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGILVSKFGWVASNTVLY 420
Cdd:cd17345   318 WLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVLL 397
                         410
                  ....*....|....
gi 2532542707 421 AAAFIALFLLIYIL 434
Cdd:cd17345   398 ASCILAIIFLALVA 411
 
Name Accession Description Interval E-value
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
28-434 2.77e-143

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 415.49  E-value: 2.77e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  28 QTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAV 107
Cdd:cd17345     1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLG----STQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQF-ATFLFT 182
Cdd:cd17345    81 INILIGfvpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLgLAIFGD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 183 DSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLDTGEENNKEvssLSLPQIFMKYILNNKMVWAIT 262
Cdd:cd17345   161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQE---LSAWEIFVKYVLKNKLLWYIA 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 263 LTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL-KNYRAIVCIGCVVGLIACLTAY 340
Cdd:cd17345   238 IANVFVYLVRYGILDWAPTYLSEvKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfKGRRAPTGIIFMILVIVALIVY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 341 FFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGILVSKFGWVASNTVLY 420
Cdd:cd17345   318 WLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVLL 397
                         410
                  ....*....|....
gi 2532542707 421 AAAFIALFLLIYIL 434
Cdd:cd17345   398 ASCILAIIFLALVA 411
glpT PRK11273
glycerol-3-phosphate transporter;
1-448 4.30e-91

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 283.52  E-value: 4.30e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707   1 MFSFLKPAPdSKKKVPANKIKSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQtPIMKAYHFSTAQIGLILSCFGIGYGI 80
Cdd:PRK11273    1 MLSIFKPAP-HKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAM-PYLVEQGFSRGDLGFALSGISIAYGF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  81 SKLFMGALSDKSNPNHYLAAGLFISAVLNIFLG----STQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIY 156
Cdd:PRK11273   79 SKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGfvpwATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 157 SIWSSAHNAGAFACVAIVQFATFLFTDsIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQlDTGEENN 236
Cdd:PRK11273  159 SVWNCAHNVGGGLPPLLFLLGMAWFND-WHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPD-DYNEKHE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 237 KEvssLSLPQIFMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAIS 315
Cdd:PRK11273  237 QE---LTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFALDKSSWAYFLYEYAGIPGTLLCGWMS 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 316 D-LLKNYRAIVCIGCVVGLIACLTAYFFSQ--NHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQY 392
Cdd:PRK11273  314 DkVFRGNRGATGVFFMTLVTIATIVYWLNPagNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGY 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2532542707 393 IFGETLATALIGILVSKFGWVASNTVLYAAAFIALFLLIYILIREKKDIQEEVKEA 448
Cdd:PRK11273  394 LGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQKR 449
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
37-412 1.81e-78

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 248.44  E-value: 1.81e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  37 IGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQ 116
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 117 NFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAfACVAIVQFATFLFTDSIRDVFYTASAVA 196
Cdd:TIGR00881  82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGG-GLLPPLVLFGIAELYSWHWVFIVPGIIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 197 IIIGIFILLVGSDRPTTVGLPSITEYTGDviqlDTGEENNKEVSSLSLPQIFMKYILNNKMVWAITLTSMFLYLVRYGIM 276
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNE----EPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGIL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 277 SWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISD-LLKNYRAIVCIGCVVGLIACLTAYF--FSQNHVLIVVI 352
Cdd:TIGR00881 237 DWSPLYLTQeKGFSKEKASWAFTLYELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVYWlnPAANPLMDLIC 316
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 353 LLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGW 412
Cdd:TIGR00881 317 LFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGG-ILAGLPLGYLADGFGW 375
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
21-439 3.61e-49

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 171.59  E-value: 3.61e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  21 KSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAA 100
Cdd:COG2271     1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 101 GLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFL 180
Cdd:COG2271    81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 181 FtdSIRDVFYTASAVAIIIGIFillvgsdrpttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnkMVWA 260
Cdd:COG2271   161 F--GWRAAFLILGLPGLLLALL------------------------------------------------------RFWL 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 261 ITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTA 339
Cdd:COG2271   185 LALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLL 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 340 YFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGWVASNTVL 419
Cdd:COG2271   265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG-ALGPLLVGYLLDATGYQAAFLLL 343
                         410       420
                  ....*....|....*....|
gi 2532542707 420 YAAAFIALFLLIYILIREKK 439
Cdd:COG2271   344 AALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
31-393 4.27e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 102.50  E-value: 4.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIIRLIFTTeqtPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPL---LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFY 190
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLdtgeennkevsslslpqifmKYILNNKMVWAItLTSMFLYL 270
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW--------------------KALLRDPVLWLL-LALLLFGF 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAI-VCIGCVVGLIACLTAYFFSQNHVLI 349
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLlLALLLLILAALGLLLLSLTLSSLWL 294
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2532542707 350 VVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYI 393
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
 
Name Accession Description Interval E-value
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
28-434 2.77e-143

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 415.49  E-value: 2.77e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  28 QTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAV 107
Cdd:cd17345     1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLG----STQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQF-ATFLFT 182
Cdd:cd17345    81 INILIGfvpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLgLAIFGD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 183 DSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLDTGEENNKEvssLSLPQIFMKYILNNKMVWAIT 262
Cdd:cd17345   161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQE---LSAWEIFVKYVLKNKLLWYIA 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 263 LTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL-KNYRAIVCIGCVVGLIACLTAY 340
Cdd:cd17345   238 IANVFVYLVRYGILDWAPTYLSEvKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfKGRRAPTGIIFMILVIVALIVY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 341 FFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGILVSKFGWVASNTVLY 420
Cdd:cd17345   318 WLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVLL 397
                         410
                  ....*....|....
gi 2532542707 421 AAAFIALFLLIYIL 434
Cdd:cd17345   398 ASCILAIIFLALVA 411
glpT PRK11273
glycerol-3-phosphate transporter;
1-448 4.30e-91

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 283.52  E-value: 4.30e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707   1 MFSFLKPAPdSKKKVPANKIKSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQtPIMKAYHFSTAQIGLILSCFGIGYGI 80
Cdd:PRK11273    1 MLSIFKPAP-HKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAM-PYLVEQGFSRGDLGFALSGISIAYGF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  81 SKLFMGALSDKSNPNHYLAAGLFISAVLNIFLG----STQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIY 156
Cdd:PRK11273   79 SKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGfvpwATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 157 SIWSSAHNAGAFACVAIVQFATFLFTDsIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQlDTGEENN 236
Cdd:PRK11273  159 SVWNCAHNVGGGLPPLLFLLGMAWFND-WHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPD-DYNEKHE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 237 KEvssLSLPQIFMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAIS 315
Cdd:PRK11273  237 QE---LTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFALDKSSWAYFLYEYAGIPGTLLCGWMS 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 316 D-LLKNYRAIVCIGCVVGLIACLTAYFFSQ--NHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQY 392
Cdd:PRK11273  314 DkVFRGNRGATGVFFMTLVTIATIVYWLNPagNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGY 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2532542707 393 IFGETLATALIGILVSKFGWVASNTVLYAAAFIALFLLIYILIREKKDIQEEVKEA 448
Cdd:PRK11273  394 LGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQKR 449
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
37-412 1.81e-78

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 248.44  E-value: 1.81e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  37 IGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQ 116
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 117 NFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAfACVAIVQFATFLFTDSIRDVFYTASAVA 196
Cdd:TIGR00881  82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGG-GLLPPLVLFGIAELYSWHWVFIVPGIIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 197 IIIGIFILLVGSDRPTTVGLPSITEYTGDviqlDTGEENNKEVSSLSLPQIFMKYILNNKMVWAITLTSMFLYLVRYGIM 276
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNE----EPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGIL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 277 SWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISD-LLKNYRAIVCIGCVVGLIACLTAYF--FSQNHVLIVVI 352
Cdd:TIGR00881 237 DWSPLYLTQeKGFSKEKASWAFTLYELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVYWlnPAANPLMDLIC 316
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 353 LLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGW 412
Cdd:TIGR00881 317 LFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGG-ILAGLPLGYLADGFGW 375
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
33-447 2.78e-64

hexose-6-phosphate:phosphate antiporter;


Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 214.14  E-value: 2.78e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  33 LAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVL---- 108
Cdd:PRK09556   32 LVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICmlgf 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 109 NIFLGSTQNFYVMMFLMLVIS-IAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQF-ATFLFTDSIR 186
Cdd:PRK09556  112 GASLGSGSVSLGLMIALWALSgFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWgANYFFDGHVI 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 187 DVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLDTGEENNKEVSSLslpQIFMKYILNNKMVWAITLTSM 266
Cdd:PRK09556  192 GMFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETESTDMTKW---QIFVEYVLKNPVIWLLCFANI 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 267 FLYLVRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAYFFSQN 345
Cdd:PRK09556  269 FLYIVRIGIDNWSPVYAFQElGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRRALVACIALALIIFTLGVYQHATS 348
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 346 HVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGILVSKF------------GWV 413
Cdd:PRK09556  349 EYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDSFAKVGLGMIADPTkngtpifgytltGWA 428
                         410       420       430
                  ....*....|....*....|....*....|....
gi 2532542707 414 ASNTVLYAAAFIALFLLIYILIREKKDIQEEVKE 447
Cdd:PRK09556  429 GTFAALDIAAIGCICLMAIVAVMEERKIRREKKI 462
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
31-431 2.40e-54

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 185.17  E-value: 2.40e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17312     4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFacVAIVQFATFLFTDSIRDVFY 190
Cdd:cd17312    84 FMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGI--LAPILAASLASYYGWRAAFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVGSDRPttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYL 270
Cdd:cd17312   162 VPGIVGLVVAIILFFFLRDSP--------------------------------------------PYVWVLSLAYAFVYI 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL-KNYRAIVCIGCVVGLIACLTAYFFS-QNHV 347
Cdd:cd17312   198 VRYACLDWGPLYLYEvKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMTLSLALFWFFpHNKL 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 348 LIVVILLIMGSLIYAPLTLVGLMVNEAV-PKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGWVASNTVLYAAAFIA 426
Cdd:cd17312   278 LSIVLLFLIGFFVGGPINLIGGAAAQDIgRKEAAGTATGFVGLFGYLGA-SLAGLPLGYIIDHYGWSTVFYFLISAALLS 356

                  ....*
gi 2532542707 427 LFLLI 431
Cdd:cd17312   357 VLLLL 361
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
19-433 4.38e-52

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 181.06  E-value: 4.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  19 KIKSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYL 98
Cdd:PRK11663   12 EIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFM 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  99 AAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFAT 178
Cdd:PRK11663   92 GIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIA 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 179 FLFtdSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLdtgeENNKEVSSLSLPQIFMKYILNNKMV 258
Cdd:PRK11663  172 LHY--GWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALEL----AQQQEGAGLSRKEILTKYVLLNPYI 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 259 WAITLTSMFLYLVRYGIMSWIPSYLV-QKGFSPDFAKWLVGIFELSAVPGVILIGAISD-LLKNYRAIVCIGCVVGLIAC 336
Cdd:PRK11663  246 WLLSFSYVLVYVVRAAINDWGNLYMSeTLGVDLVTANSAVSMFELGGFIGALVAGWGSDkLFNGNRGPMNLIFAAGILLS 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 337 LTAYFF--SQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWVA 414
Cdd:PRK11663  326 VGSLWLmpFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GAALSGYPLAKVLEIWHWTG 404
                         410       420
                  ....*....|....*....|
gi 2532542707 415 SNTVL-YAAAFIALFLLIYI 433
Cdd:PRK11663  405 FFVVIsIAAGISALLLLPFL 424
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
21-439 3.61e-49

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 171.59  E-value: 3.61e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  21 KSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAA 100
Cdd:COG2271     1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 101 GLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFL 180
Cdd:COG2271    81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 181 FtdSIRDVFYTASAVAIIIGIFillvgsdrpttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnkMVWA 260
Cdd:COG2271   161 F--GWRAAFLILGLPGLLLALL------------------------------------------------------RFWL 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 261 ITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTA 339
Cdd:COG2271   185 LALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLL 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 340 YFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGWVASNTVL 419
Cdd:COG2271   265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG-ALGPLLVGYLLDATGYQAAFLLL 343
                         410       420
                  ....*....|....*....|
gi 2532542707 420 YAAAFIALFLLIYILIREKK 439
Cdd:COG2271   344 AALALLAALLALLLLRETRK 363
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
31-431 3.63e-39

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 144.86  E-value: 3.63e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17488     4 ILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFY 190
Cdd:cd17488    84 LFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTY--GWRAGMY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVGSDRPttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYL 270
Cdd:cd17488   162 VPGIIAILMGIVLCWRLRDRP--------------------------------------------PYIWLLAFCYVLVYV 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL-KNYRAIVCIGCVVGLIACLTAYFFSQNH-- 346
Cdd:cd17488   198 VRTAINDWGNLYLSEtHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLfKGNRGPMNLIFALGLLVSVGALWLVPVHsy 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 347 VLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYiFGETLATALIGILVSKFGWVASNTVLYAAAFIA 426
Cdd:cd17488   278 WLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAY-LGAALAGYPLAKVIESWGWSGFFIVISIAAAIS 356

                  ....*
gi 2532542707 427 LFLLI 431
Cdd:cd17488   357 GLLLL 361
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
28-430 5.40e-28

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 114.74  E-value: 5.40e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  28 QTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAV 107
Cdd:cd17343     1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHN-AGAFACVaivqFATFLFTD-SI 185
Cdd:cd17343    81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNlAGSLGPI----LATLLALSyGW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 186 RDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEytgdviqldtgEENNKEVSSLSLPQIFMKYILNNKMVWAITLTS 265
Cdd:cd17343   157 RSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE-----------EESKGKKKKSPRGESTLKELLLSPFLWLLSLGY 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 266 MFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL---------KNYRAIVCIGCVVGLIA 335
Cdd:cd17343   226 LVVFGVKTAVTDWGQLFLIQdKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAvakhgsssrGNPRMPLALVFMAGLTV 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 336 CLTAYFF----SQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYiFGETLATALIGILVSKFG 411
Cdd:cd17343   306 SLHLFRVhitsDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAAN-VGGVLAGLPFSYIAKHYD 384
                         410
                  ....*....|....*....
gi 2532542707 412 WVASNTVLYAAAFIALFLL 430
Cdd:cd17343   385 WRTAFLLLEILCAITVVIL 403
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
35-431 2.95e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 112.13  E-value: 2.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  35 ICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGS 114
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 115 TQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFTDSIRDVFYTASA 194
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 195 VAIIIGIFILLVGSDRPttvglpsiteytgdviqldTGEENNKEVSSLSLPQIFMKYILNNKMVWAITLTSMFLYLVRYG 274
Cdd:cd06174   161 LALLAAILLLLVVPDPP-------------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 275 IMSWIPSYLVQKG-FSPDFAKWLVGIFELSAVPGVILIGAISDLLKNyRAIVCIGCVVGLIACLTAYFFSQNHVLIVVIL 353
Cdd:cd06174   222 FSTLLPLFLLDLGgLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG-RKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 354 LIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGILVSKFGWVASNTVLYAAAFIALFLLI 431
Cdd:cd06174   301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
22-396 9.10e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 104.67  E-value: 9.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  22 STYIWRQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAG 101
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 102 LFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLF 181
Cdd:COG2814    82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 182 tdSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEytgdviqldtgeennkevsslslpqifMKYILNNKMVWAI 261
Cdd:COG2814   162 --GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS---------------------------LRELLRRPRLLLL 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 262 TLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIvcIGCVVGLIACLTAY 340
Cdd:COG2814   213 LLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL--LIGLLLLALGLLLL 290
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2532542707 341 FFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGE 396
Cdd:COG2814   291 ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
31-435 1.95e-24

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 103.80  E-value: 1.95e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17319     4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFY 190
Cdd:cd17319    84 LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF--GWRWAFI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVGsdrpttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYL 270
Cdd:cd17319   162 IEGLLGLLLAVLWWFYL------------------------------------------------RQVWGLALGYFGINY 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNY-RAIVCIGCVVGLIACLTAYFFSQNHVL 348
Cdd:cd17319   194 ALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGaRRLVIIIGLLLAAVGLLLAYLTTSPVV 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 349 IVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGwvASNTVLYAAAFIALF 428
Cdd:cd17319   274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL-GGFVAPLLIGYLVDATG--SYTAAFLFLAAVALL 350

                  ....*..
gi 2532542707 429 LLIYILI 435
Cdd:cd17319   351 AALLVLL 357
MFS_1 pfam07690
Major Facilitator Superfamily;
31-393 4.27e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 102.50  E-value: 4.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIIRLIFTTeqtPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPL---LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFY 190
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLdtgeennkevsslslpqifmKYILNNKMVWAItLTSMFLYL 270
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW--------------------KALLRDPVLWLL-LALLLFGF 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAI-VCIGCVVGLIACLTAYFFSQNHVLI 349
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLlLALLLLILAALGLLLLSLTLSSLWL 294
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2532542707 350 VVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYI 393
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
27-439 4.44e-23

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 100.34  E-value: 4.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  27 RQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISA 106
Cdd:COG2223     2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 107 VLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIR 186
Cdd:COG2223    82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF--GWR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 187 DVFYTASAVAIIIGIFILLVGSDRPttvglpsiteytgdviqldtgeENNKEVSSLSLPQIfmKYILNNKMVWAITLTSM 266
Cdd:COG2223   160 NAFLILGILLLVVAVLAWLFLRDPP----------------------AGAAAAAKASLRDQ--LEALRDPRFWLLSLLYF 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 267 FLYLVRYGIMSWIPSYLV-QKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIACLTAYFFSQN 345
Cdd:COG2223   216 GTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL-IVFALMALGLLLLALALGS 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 346 HVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFG-WVASNTVLYAAAF 424
Cdd:COG2223   295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGG-FLGPLLFGALLDATGsYTAAFLVFAVLAL 373
                         410
                  ....*....|....*
gi 2532542707 425 IALFLLIYILIREKK 439
Cdd:COG2223   374 VALVLTLLLYRRPRR 388
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
31-436 2.26e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 92.25  E-value: 2.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIIRLIFTteqtPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILP----LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFY 190
Cdd:cd17325    77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL--GYRAPFL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVgsdrpttvgLPsiteytgdviqlDTGEENNKEVSSLSLPQIFMKYILNNKMVWAITLTSMFLYL 270
Cdd:cd17325   155 VCAALALLALVLALLL---------LP------------EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAF 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKnyRAIVCIGCVVGLIACLTAYFFSQNHVLI 349
Cdd:cd17325   214 AFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG--RKPLILIGLLLSAVALLLLPLATSFWLL 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 350 VVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWvaSNTVLYAAAFIALFL 429
Cdd:cd17325   292 LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGF--ATPFLAAAALLLLAA 368

                  ....*..
gi 2532542707 430 LIYILIR 436
Cdd:cd17325   369 VLFLLLR 375
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
55-436 1.12e-19

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 90.32  E-value: 1.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  55 PIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGM 134
Cdd:COG2807    43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 GAAACQRTVQLWWGKkRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFYTASAVAIIIGIFILLVGSDRPTTV 214
Cdd:COG2807   123 GNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAAL--GWRGALAVWALLALLALLLWLPLLRRRPAAA 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 215 GLPSiteytgdviqldtgeennKEVSSLSLpqifmkyiLNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAK 294
Cdd:COG2807   200 AAAP------------------AAASLRSL--------WRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAG 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 295 WLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILL--IMGSLIYAPLTLVGLMVN 372
Cdd:COG2807   254 LLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLglGQGGLFPLALTLIGLRAR 333
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2532542707 373 EAVpkfAVGSSTGFMGFFQYIFGeTLATALIGILVSKFG-WVASNTVLyAAAFIALFLLIYILIR 436
Cdd:COG2807   334 TPA---EAAALSGMAQSVGYLLA-ALGPLLVGALHDATGsWTAALLLL-AALAVLMLVAGLLAGR 393
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
56-431 1.39e-18

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 86.84  E-value: 1.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGM- 134
Cdd:cd17478    22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAf 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 ---GAAACQRTvqlwwGKKRRGAIYSIWSSAHNAGaFACVAIvqFATFLFTDSIRDVFYTASAVAIIIGIFILLVGSDRP 211
Cdd:cd17478   102 hpeGARLASQA-----AGGRRGLAMSIFSVGGNLG-FALGPL--IAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 212 ttvgLPSITEYTGDVIQLDTgeennkevsslslpqifmkYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPD 291
Cdd:cd17478   174 ----KPEAKKAAAKSSARST-------------------LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 292 FAKWLVGIFELSAVPGVILIGAISDLLkNYRAIVCIGCVVGLIacLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMV 371
Cdd:cd17478   231 FAGLLLSLFLFAGAIGTLIGGPLSDRF-GRRRVIIASLLLAAP--FLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLA 307
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 372 NEAVPKFAVGSSTGFMGFFQYIFGetLATALIGILVSKFGWVASNTVLYAAAFIALFLLI 431
Cdd:cd17478   308 QELLPGNVGLASGLMMGLSFGLGG--IGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
56-439 3.22e-17

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 82.98  E-value: 3.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMG 135
Cdd:COG0738    34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLL 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRTVqLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFL-FTDSIRDVFYTASAVAIIIGIFILLvgsdrpttV 214
Cdd:COG0738   114 DVAANPYV-AALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLgLSLSWHLPYLILAVLLLLLALLFLR--------S 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 215 GLPSITEYTGDVIQLDTGeennkevsslslpqifMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFA 293
Cdd:COG0738   185 KLPEIEEEEEEAAGSAAS----------------LKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATA 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 294 KWLVGIFELSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIACLTAYFFSQNHVLIVVILLI--MGSLIYAplTLVGLMV 371
Cdd:COG0738   249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLR-LSALLAAVGLLLALLAPGPWLALIGLALVglGLSLMFP--TIFSLAL 325
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 372 nEAVPKFAVGSSTGFMGFfqYIFGETLATALIGILVSKFGWVASNTVLyAAAFIALFLLIYILIREKK 439
Cdd:COG0738   326 -DGLGKRTAAAVSAVLIM--GIVGGAIGPPLIGFLADAFGLRAAFLVP-LVCYLLILLLALALKRKRR 389
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
32-431 3.81e-17

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 82.60  E-value: 3.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  32 LLAICIGYIGYYIIRLIftteqTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIF 111
Cdd:cd17324     6 LAAFAIGTTEYVIQGLL-----PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 112 LGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFYT 191
Cdd:cd17324    81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL--GWRAAFLA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 192 ASAVAIIIGIFILLVgsdrpttvgLPSITEytgdviqldtgeenNKEVSSLSLPQIFMkyILNNKMVWAITLTSMFLYLV 271
Cdd:cd17324   159 IAVLALLAALLLWRL---------LPSLPP--------------KKPGSLGLLSSLLL--LLRNPRLRLAYLITFLLFGG 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 272 RYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTayFFSQNHVLIV 350
Cdd:cd17324   214 FFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLT--LLGPSPLLLL 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 351 VILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYifGETLATALIGILVSKFGWVASNTVLYAAAFIALFLL 430
Cdd:cd17324   292 VGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNL--GGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369

                  .
gi 2532542707 431 I 431
Cdd:cd17324   370 L 370
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
59-431 6.74e-16

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 78.82  E-value: 6.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  59 AYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVIsiaqGMGAAA 138
Cdd:cd17475    25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV----GAGYGS 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 139 CQ----RTVQLWWGKKRRGAIYSIWSSAHNAGAFacVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFILLVGSDRPTTV 214
Cdd:cd17475   101 VQpgggRAIMRWFPPRERGLAMGIRQTGVPLGGA--LAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAAS 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 215 GLPSITeytgdviqldtgeenNKEVSSLSLPqifmkyiLNNKMVWAITLTSMFLYLVRYGIMSWIPSYLV-QKGFSPDFA 293
Cdd:cd17475   179 AATESA---------------STLLRSLKEV-------LRNRDVWLIAIAGALLVAPQFALLTFLLLFLHdHLGLSVVAA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 294 KWLVGIFELSAVPGVILIGAISDLL--KNYRA-IVCIGCVVGLIACLTAYFFSQNHVLIVVILLI---MGSLIYAPLTLV 367
Cdd:cd17475   237 GALLAVAQLGGALGRIGLGRVSDRVfgGRRRPvLVITAAIAAAALLVLSLLSPGTPLWLLVLLLIllgLFAIGWNGLYLT 316
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 368 glMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKfgwvasnTVLYAAAFIALFLLI 431
Cdd:cd17475   317 --LVAESAGPEQAGTALGLANTINFI-GIAIGPPLFGLLVDA-------THSYAPAWLALALLL 370
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
31-429 9.29e-15

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 75.39  E-value: 9.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17355     4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQ-GMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQfaTFLFTDSIRDVF 189
Cdd:cd17355    84 LLALATSLWQLYLLWGLLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGA--ALIEAFGWRTAL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 190 YTASAVAIIIGIFILLVGSDRPTTVGLPSITeytgdviqldtgeennkeVSSLSLPQIFMKYILNNKMVWAITLTSMFLY 269
Cdd:cd17355   162 LVLALLALLVLVPVLLLLRRRPADLALRAYD------------------DASPASPGSTLKEALRSASFWLLALAFFLCG 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 270 LVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLkNYRAIVCIGCVVGLIACLTAYFFSQNHVLI 349
Cdd:cd17355   224 FAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRY-SPRRLLAASYALRALGLALLLLLPFPPLAL 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 350 VVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMgFFQYIFGETLATALIGILVSKFG-----WVASNTVLYAAAF 424
Cdd:cd17355   303 LLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLV-FAPHQLGSALGPWLGGLLYDRTGsytaaWALAVALGLIAAL 381

                  ....*
gi 2532542707 425 IALFL 429
Cdd:cd17355   382 LVLPI 386
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
57-433 2.13e-13

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 71.05  E-value: 2.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  57 MKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGA 136
Cdd:cd17477    23 LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLF 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 137 AACQRTVQLWWGKKRRGAIYSIWSSAHNAGafacVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFILLVGSDRPTTvgl 216
Cdd:cd17477   103 VVSESWLNALATNENRGRVLGLYSTVLGLG----FALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEI--- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 217 psiteytgdviqldtgeennKEVSSLSLPQIFMKYILnnkmvwaiTLTSMFLY-LVRYGIMSWIPSYLVQKGFSPDFAKW 295
Cdd:cd17477   176 --------------------EEAESISLRRLLRIAPL--------ALLGAFVAgFLEGAFYSLLPLYGLRLGLSVAQAAL 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 296 LVGIFELSAVPGVILIGAISDLLKNYRAIVCIgCVVGLIACLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAV 375
Cdd:cd17477   228 LLAAFVLGGLLLQWPLGWLADRFDRRRVLLGC-ALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRL 306
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 376 PKFAVGSSTGFMGFFqYIFGETLATALIGILVSKFGwvaSNTVLYAAAFIALFLLIYI 433
Cdd:cd17477   307 PGDELVAANAALLLL-YGLGSVIGPLLAGALMDAFG---PHGLFLFLAAVALLFLLFL 360
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
58-411 4.80e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 64.17  E-value: 4.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  58 KAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAA 137
Cdd:cd17329    28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEP 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 138 ACQRTVQLWWGKKRRGAIYSIWSSAHNAGAfACVAIVqfATFLFTDSIRDVFyTASAVAIIIGIFILLVGSDRPTTVGLP 217
Cdd:cd17329   108 ASEAMIADVTTPENRTRAFSLLYWAINLGV-AIGPLL--GGLLLLYSFRLLF-LAAAVLFLLAALVLLFLLPETRPKRRA 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 218 SITEYTGDVIQLdtgeennkevsslslpqifmkyILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAkwLV 297
Cdd:cd17329   184 AEKTEILRGYKI----------------------VLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL--LG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 298 GIFELSAVPGVILIGAISDLLKNYRAIVCIG-CVVGLIACLTAYFFSQN--HVLIVVILLIMGSLIYAPltlvglMVNEA 374
Cdd:cd17329   240 LLLALNALLIVLLQFPVARLVERFRLRKILMiGILLFAIGFAVLAFANTlaVLILAMIVLTLGEMLVFP------AVQTL 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2532542707 375 VPKFAVGSSTG-FMGFFQ--YIFGETLATALIGILVSKFG 411
Cdd:cd17329   314 VAALAPPDKRGsYMGFYAlaWGLGRAIGPLVGGLLLDLLG 353
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
47-434 4.95e-11

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 64.25  E-value: 4.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  47 LIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLML 126
Cdd:cd17371    16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 127 VISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIvqfATFLFTDSI-----RDVFYTASAVAIIIgI 201
Cdd:cd17371    96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLL---AALLFPLLPpeiawRVLFLLGALPALLV-L 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 202 FILLVGSDRPttvglpsiteytgdvIQLDTGEENNKEVSSLSLPQIFMKYILNNKMVWaiTLTSMFLYLVRYGIMSWIPS 281
Cdd:cd17371   172 FIRRFVKEPP---------------QWQAARAARRHFADRPSLRELFSPPLLRTTLLA--SLLATGALGGYYGITTWLPS 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 282 YL-VQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNyRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLIMGSLI 360
Cdd:cd17371   235 YLtGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGR-RNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFA 313
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2532542707 361 YAPLTLVGLMVNEAVPKFAVGSSTGFMgffqYIFGE---TLATALIGILVSKFGWVASNTVLYAAAFIALFLLIYIL 434
Cdd:cd17371   314 SGPFSGMGAYLTELFPTAVRATAQGFC----YNVGRiigALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
56-433 1.40e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 62.59  E-value: 1.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYvmmfLMLVISIAQGMG 135
Cdd:cd17474    25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA----LLLAGRALQGIG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRT-----VQLWWGKKRRGAIySIWSSAHNAGAFACVAIvqfATFLFTDSIRDVFYtASAVAIIIGIFILLVGSDR 210
Cdd:cd17474   101 AAGLGPLaltliGDLFEGGERAKAM-GLYEAALGLGIAVGPLL---GGLLAAISWRYPFF-LLAALIPVAFLAILFLLPE 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 211 PTTVGLPSITEYTGDviqldtgeennkevsslslpqifMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQK-GFS 289
Cdd:cd17474   176 PKEKAKSSSATKLRD-----------------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGIS 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 290 PDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVgLIACLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGL 369
Cdd:cd17474   233 PIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLL-YALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTT 311
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 370 MVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWVASNTVLYAAAFIALFLLIYI 433
Cdd:cd17474   312 LVTELAPEEERGTASSLYNFVRFL-GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
252-369 1.41e-10

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 62.59  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 252 ILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVV 331
Cdd:cd17339   192 VWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVL 271
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2532542707 332 GLIACLTAYFFSQNHVLIVVILLI--MGSLIYAPLTLVGL 369
Cdd:cd17339   272 FIIGVLGLLFAPTALALLWAVLLGlgGGAAFSLALTLISL 311
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
56-434 5.20e-10

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 60.80  E-value: 5.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQG-M 134
Cdd:cd17333    22 LEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGiL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 GAAACQRTVQLWwgKKRRGAIYSIWSSAHNAGAFACVAIvqfATFLFTDSIR--DVFYTASAVAIIIGIFILLVGSDRpt 212
Cdd:cd17333   102 DTGANTFVGALF--EESSATRLNVLHGFFGLGALIGPLI---ATSLLTSELSwsWAYLIIGLIYLLLAILILLTLFPE-- 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 213 tvglpsiTEYTGDVIQLDTGEennkevsslslpQIFMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPD- 291
Cdd:cd17333   175 -------LPSARNPQQSVGAF------------SASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDg 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 292 FAKWLVGIFELSAVPGVILIGAISDLLKnYRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLImgSLIYAPLTLVGLMV 371
Cdd:cd17333   236 LAGYLLSGFWVGITIGRLLGGPISRRIK-PHTLLVLSGSGALLGLLILLLAPTLVVGLVATALL--GLFMAALFPTILSL 312
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2532542707 372 NEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWVAsnTVLYAAAFIALFLLIYIL 434
Cdd:cd17333   313 GISNLPYAKGKGTSVLLAAGSI-GGAIIPFIMGFIAEAVGIQT--AMLLITILYAIIFVLALL 372
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
6-205 2.28e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 58.74  E-value: 2.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707   6 KPAPDSKKKVPANKIKSTYIW--RQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKL 83
Cdd:cd17325   174 PRPPPNKRAVSAARLRSGLRLllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQP 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  84 FMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAH 163
Cdd:cd17325   254 PAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF 333
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2532542707 164 NAGAFACVAIVQFATFLFtdSIRDVFYTASAVAIIIGIFILL 205
Cdd:cd17325   334 SLGMVLGPLLGGFLYDAF--GFATPFLAAAALLLLAAVLFLL 373
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
33-448 3.80e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 58.37  E-value: 3.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  33 LAICIGYIGYYIIRLIFTTEQtpimkaYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNH-----YLAAGLFISAV 107
Cdd:COG2211    20 LGLNLAFGLLSAYLLYFYTDV------LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLAL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLGSTQNFYVMMFL--MLVISIAQGMGAAACQrtvQLWWG--------KKRRGAIYSIWSSAHNAGAFACVAIVQFA 177
Cdd:COG2211    94 SFVLLFTAPDLSPTGKLiyALVTYLLLGLAYTLVN---IPYSAlgaeltpdYEERTRLSSWRFAFAGLGGLLASVLPPPL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 178 TFLFTDSIRD-VFYTASAVAIIIGIFILLVGsdrpttvglpsiteytgdviqLDTGEENNKEVSSLSLPQIFmKYILNNK 256
Cdd:COG2211   171 VAAFGGDAALgYRLTALIFAVLGLLAFLLTF---------------------FGTKERPVPEEEKVSLKESL-KALLKNR 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 257 MVWAITLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIA 335
Cdd:COG2211   229 PFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI-IGLLLAALG 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 336 CLTAYFFSQNHV-LIVVILLIMGSLIYAPLTLVGLMVNEAVP-------KFAVGSSTGFMGFFQYIfGETLATALIGILV 407
Cdd:COG2211   308 LLLLFFLGPGNLwLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKL-GQALAGALAGLLL 386
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 408 SKFGWVASNT-------------VLYAAAFIALFLLIYILIREKKDIQEEVKEA 448
Cdd:COG2211   387 ALFGYVAGAAqspsaltgirllfFLLPAVLLLLAALLLLFYPLTRERHAEIRAE 440
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
58-447 1.66e-08

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 56.68  E-value: 1.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  58 KAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFL--GSTQNFYVMMFLMLVISIAQGMG 135
Cdd:TIGR00894  69 PNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSV 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRTVQLWWGKKRRGAIYSIwssahnagafaCVAIVQFATFLF---TDSIRD-------VFYTASAVAIIIGIFILL 205
Cdd:TIGR00894 149 SPATHKIIVKWAPPKERSRLLGM-----------STSGFQLGTFIFlpiSGWLCEswggwpmIFYVFGIVGCAWSLLWFV 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 206 VGSDRPTTVglPSITEYTGDVIqldtGEENNKEVSSLSLPQIFmKYILNNKMVWAITLtsmflylvryGIMSWIPSYLVQ 285
Cdd:TIGR00894 218 FPADDPSIH--PCISKFEKKYI----NSSLQGQKGSTRQSLPI-KAIPKSLPVWAIWF----------AIFGHFWLYTIL 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 286 KGFSPDFAKWLVG--IFE---LSAVPGV------ILIGAISDLLKN--------YRAIVC-IGCVVGLIACLTAYFFSQN 345
Cdd:TIGR00894 281 PTYLPTFISWVLRvsGKEnglLSSLPYLfawlcsIFAGYLADFLKSsktlsltaARKIFNgIGGLGPGIFAYALPYLSAA 360
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 346 HVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFA--VGSSTGFMGFFQYIFGETLAtaliGILVSKFGWVASNTVLYAAA 423
Cdd:TIGR00894 361 FYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLgfIKGITGLPGFIGGLIASTLA----GNILSQDSKNVWLIVFLIMA 436
                         410       420
                  ....*....|....*....|....
gi 2532542707 424 FIALFLLIYILIREKKDIQEEVKE 447
Cdd:TIGR00894 437 FVNILCVIFYLIFGSAERQDWAKE 460
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
32-435 5.06e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 54.93  E-value: 5.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  32 LLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIF 111
Cdd:cd17328     1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 112 LGSTQNFyvmmFLMLVISIAQGMGAAACQRTVQLWWG----KKRRGAIYSIWSSAHNAGAFACVaIVQFATFLFTDSIRD 187
Cdd:cd17328    81 SSFAPNF----WQLLLFRALVGIGEASYSPIAPTIIAdlfpKEKRTRALGVFYFAIPLGSGLGY-VVGGLVAQATGGWRW 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 188 VFYTASAVAIIIGIFILLVGSDRPTTVGlpsiteytgdviqlDTGEENNKEVSSLSLPqifMKYILNNKMVWAITLTSMF 267
Cdd:cd17328   156 AFRVTGVLGVLLAILLLLFVREPPRGAA--------------EGGVMAKSTATSFLAD---LKALAKNPSFILSTLGFTA 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 268 LYLVRYGIMSWIPSYL-----VQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNY----RAIVCIGCVVGLI--AC 336
Cdd:cd17328   219 VSFVTGALAFWAPTFFlrafgVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKtpraDPLVCAVGLLAAApfLF 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 337 LTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGiLVSKFGWVASN 416
Cdd:cd17328   299 LALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIG-LISDLLRQNKD 377
                         410       420
                  ....*....|....*....|.
gi 2532542707 417 TVLYAAAFI--ALFLLIYILI 435
Cdd:cd17328   378 SPLAEAASLqyALLLCSFVLV 398
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
63-437 6.44e-08

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 54.63  E-value: 6.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  63 STAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLG-----STQNFYVMMFLMLVISIAQGMGAA 137
Cdd:cd17344    60 GTELLGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGlgyywNIHSLWYFVVVQILAGLFQSTGWP 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 138 ACQRTVQLWWGKKRRGAIYSIWSSaHNA-----GAFACVAIVQFA---TFlftdsirdvfytasavaIIIGIFILLVGsd 209
Cdd:cd17344   140 SVVACVGNWFGKGKRGLIMGIWNS-HTSvgnilGSLIAGIFVSSAwglSF-----------------IVPGIIIAAMG-- 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 210 rpttvglpsiteytgdVIqldtgeennkevsslslpqIFMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKG-F 288
Cdd:cd17344   200 ----------------VL-------------------VFLFLVEHPPGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAiL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 289 SPDFAKWLVGIFELSAVPGVILIGAISDLLKNyRAIVCIGCVVGLIACLTAY-FFSQNHVLIVVILLIM-GSLIYAPLTL 366
Cdd:cd17344   245 SAKKAGDLSTLFDVGGIVGGILAGYISDYTGG-RATTCAAMLILAAPMLFIYnYFGQVSMTTNIVLLIVcGLLVNGPYAL 323
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2532542707 367 VGLMVNE--AVPKFAVGSSTGFMGFFQYIFGETLATALIGIL----VSKFGWVASNTVLYAAAFIALFLLIYILIRE 437
Cdd:cd17344   324 ITTAVSAdlGTHKSLKGNARALATVTAIIDGTGSIGAALGPLlaglISSRGWNNVFYMLIAADVCAGLLLTRLVYKE 400
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
56-403 7.63e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 54.28  E-value: 7.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMG 135
Cdd:TIGR00895  43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRTVQLWWGKKRRGAIYSIWSSAHN-----AGAFACVAIVQFATflftdsiRDVFYTASAVAIIIGIFILLV---- 206
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPigaavGGFLAGWLIPVFGW-------RSLFYVGGIAPLLLLLLLMRFlpes 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 207 ----GSDRPTTVG------LPSITEYTGDVIQLDTGEENNKEVSSLSLPQifMKYILNNKMVWAITLTSMFLYlvrYGIM 276
Cdd:TIGR00895 196 idflVSKRPETVRrivnaiAPQMQAEAQSALPEQKSTQGTKRSVFKALFQ--GKTARITVLLWLLYFMLLVGV---YFLT 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 277 SWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKnyRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLIM 356
Cdd:TIGR00895 271 NWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG--PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIA 348
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2532542707 357 GSLIYAPLTLVGLMVNEAVPKFAVGSSTGFM---GFFQYIFGETLATALI 403
Cdd:TIGR00895 349 GFFVNGGQSGLYALMALFYPTAIRATGVGWAigiGRLGAIIGPILAGYLL 398
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
67-367 1.19e-07

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 53.47  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  67 IGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQ------NFYVMMFLMLVISIAQGMGAAACQ 140
Cdd:cd17342    65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVV 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 141 RTVQLWWGKKRRGAIYSIWSSAHNA----GAFACVAIVQFA---TFLFTdsirdvfytaSAVAIIIGIFILLVGSDRPtt 213
Cdd:cd17342   145 AIMGNWFGKSSRGFVLGLWSACASVgniiGALLASSVLDYGyeyAFLVT----------SSLLFAGAIVVFFGLLSSP-- 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 214 vglPSITEYtgdviqldtgeennkevsslslpqifmkyilnnkmvwaiTLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDF 292
Cdd:cd17342   213 ---PGVIPY---------------------------------------SLAYACLKLVNYSFFFWLPFYLSNNfHWKESE 250
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2532542707 293 AKWLVGIFELSAVPGVILIGAISDLLKNyRAIVCIGCVVGLIACLTAYFFSQNHVLI-VVILLIMGSLIYAPLTLV 367
Cdd:cd17342   251 ADQLSIWYDVGGIIGGIVAGYISDRMGS-RSPVVVVMLLLAIPSLFVYSHSPSDKVLnAFVMTITGFFIGGPANLI 325
MFS_1 pfam07690
Major Facilitator Superfamily;
261-439 2.11e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.42  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 261 ITLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCigCVVGLIACLTA 339
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI--GLLLFALGLLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 340 YFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFqYIFGETLATALIGILVSKFGWVAsntVL 419
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAG-FGLGAALGPLLGGLLASLFGWRA---AF 154
                         170       180
                  ....*....|....*....|
gi 2532542707 420 YAAAFIALFLLIYILIREKK 439
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPP 174
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
60-431 2.13e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.60  E-value: 2.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  60 YHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAAC 139
Cdd:cd17316    31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 140 QRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFTDSI--RDVFytasAVAIIIGIFILLVgsdrpttvglp 217
Cdd:cd17316   111 STYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwRILF----LIGALPALLALLL----------- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 218 siteytgdviqldtgeennkevsslslpqifmkyilnNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWL 296
Cdd:cd17316   176 -------------------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLY 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 297 VGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVP 376
Cdd:cd17316   219 LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP 298
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2532542707 377 KFAVGSSTGFMGFFQYIFGETLATALIGILVSKFGWVASNTVLYAAAFIALFLLI 431
Cdd:cd17316   299 TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
61-205 3.19e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 52.23  E-value: 3.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  61 HFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQ 140
Cdd:cd06173   240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2532542707 141 RTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFYTASAVAIIIGIFILL 205
Cdd:cd06173   320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL--GLSAVFLLAGALLLLAALLLLL 382
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
256-434 3.24e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.90  E-value: 3.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 256 KMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIvcIGCVVGLIA 335
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL--LLGLLLFAL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 336 CLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWVAS 415
Cdd:COG2814    88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGL-GPALGPLLGGLLADLFGWRWV 166
                         170
                  ....*....|....*....
gi 2532542707 416 NTVLYAAAFIALFLLIYIL 434
Cdd:COG2814   167 FLVNAVLALLALLLLLRLL 185
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
30-358 1.43e-06

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 50.30  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  30 GVLLAICIGYI-GYYIIRliftteqTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVL 108
Cdd:cd17353     9 AVLMHLILGYQyAWSVFN-------PPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 109 NIFLG-STQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWgKKRRGAIYSIWSSAHNAGAFACVAIvqFATFLFTDSIRD 187
Cdd:cd17353    82 FILSAfAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPL--IAYLINTVGVPT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 188 VFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLDTGEENNKEVSSLSLPQIFMKYILNNkmVWAITLTSMF 267
Cdd:cd17353   159 TFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNA--TAGLMLIGQA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 268 LYLVRygimswipsylVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIACLTAYFFSQNHV 347
Cdd:cd17353   237 KPIGQ-----------EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLS-IAFLIQGVAMFLLPFIGSVAV 304
                         330
                  ....*....|.
gi 2532542707 348 LIVVILLIMGS 358
Cdd:cd17353   305 LFVLGVALIGF 315
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
55-436 1.52e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.89  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  55 PIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGM 134
Cdd:cd17365    24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGA 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 GAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAfacvAIVQFATFLFTDSI--RDVFYTASAVAIIIgiFILLVGSdrpt 212
Cdd:cd17365   104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGA----ALGGFLAAALIPAFgwRSVFLLGGVPPLIL--LPLLRGT---- 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 213 tvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYlvrYGIMSWIPSYLVQKGFSPDF 292
Cdd:cd17365   174 -------------------------------------------LLLWVTFFMGLLLV---YLLNSWLPKLMVEAGYSLSQ 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 293 AKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAyFFSQNHVLIVVILLIMGSLIYAPLTLvglmVN 372
Cdd:cd17365   208 ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLG-VSPASLVLLYVLVFLAGACVNGAQVG----LY 282
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 373 EAVPKF--------AVGSSTGfMGFFQYIFGETLATALIGilvskFGWVASN--TVLYAAAFIALFLLIYILIR 436
Cdd:cd17365   283 ALAARFyptevratGVGWALG-VGRLGAILGPLLGGLLLA-----AGLGPESvfLALAIPAALGALAVLLLRLR 350
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
1-207 2.29e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.49  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707   1 MFSFLKPAPDSKKKVPANKIKST---YIW-RQTGVLLAICIGYIGYYIIrliftteqtPIMKAYH------FSTAQIGLI 70
Cdd:cd17473   168 LVLLFLPEPARKSKSAASPGAATaaaLPWkRVLPIYFLAFLAMLLFYVI---------PIQLPFLlqerggGSAALIGLA 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  71 LSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKK 150
Cdd:cd17473   239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPE 318
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2532542707 151 RRGAIYSIWSSAHNAGAFACVAIVQFATFLFTDsIRDVFYTASAVAIIIGIFILLVG 207
Cdd:cd17473   319 LRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGG-LSGAFLILGVLALVLAIVLLLLR 374
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
55-433 4.38e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 48.69  E-value: 4.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  55 PIMKAYHFSTAQIGLIlscFGIGYGIS---KLFMGALSDKSNpnHY---LAAGLFISAVLNIFLGSTQNFYVMMFLMLVI 128
Cdd:cd17370    24 LFLVVLGASAAAVGLI---EGLAEALGsllRLFSGYLSDRTG--KRkplVILGYGLSALAKPLLALAGSWQLVLLLRILE 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 129 SIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFILLVGS 208
Cdd:cd17370    99 RLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVK 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 209 DRPTTVGLpsiteytgdviqldtgEENNKEVSSLSLPQIFMKYILNNkMVWAITLTSMFLYLVRYGimswipsylvQKGF 288
Cdd:cd17370   179 EYPRPPKL----------------RKKSKKTSLKKLPKAFWLYLLAV-ALFALGNFSFAFLILRAQ----------ELGL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 289 SPDFAKWLVGIFELSAVPGVILIGAISDlLKNYRAIVCIGCVVGLIACLT-AYFFSQNHVLIVVIL--LIMGSLIYAPLT 365
Cdd:cd17370   232 SAALIPLLYALFNLVYALAAYPAGRLSD-RIGRKKLLILGYLSLALAYLGfALGSSLWLLLLGFILwgLYMGAQESIERA 310
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 366 LVGLMVNEAVPKFAVGSSTGFMGFFQYIfgetlATALIGILVSKFGWVAsnTVLYAAAFIALFLLIYI 433
Cdd:cd17370   311 AVADLVPAELRGTAYGLFNTVVGIGWLL-----ASLIAGYLWDLISPSA--AFLFSAVLALIALLLLL 371
MFS_NIMT_like cd17409
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ...
249-374 7.47e-06

2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340967 [Multi-domain]  Cd Length: 374  Bit Score: 48.03  E-value: 7.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 249 MKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFEL-SAVPGVILIGAISDlLKNYRAIVCI 327
Cdd:cd17409   190 GGSVWRSPLAWQVTLFLGLNSFIYYVLVGWLPSILTDAGYSAAQAGSLHGLLQLaTAVPGLLLIPVLAR-MKDQRLLAVL 268
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2532542707 328 GCVVGLIACLTAYFFSQnHVLIVVILLIMGS---LIYApLTLVGLMVNEA 374
Cdd:cd17409   269 VSLLGAVGLIGLLLAPS-LAILWVILFGFGSgagFILG-LAFIGLRTSSA 316
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
56-408 1.03e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 47.55  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVisiaQGMG 135
Cdd:cd17321    22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARAL----QGIG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRT----VQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFYtasaVAIIIGIFILLVGsdrp 211
Cdd:cd17321    98 AAAIMPAslalIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF--GWRWIFL----INVPIGLVALLLA---- 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 212 ttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYLVRYGIMSWIPSYL-VQKGFSP 290
Cdd:cd17321   168 --------------------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLqGVLGYSP 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 291 DFAKWLVGIFELSAVPGVILIGAISDLLkNYRAIVCIGCVVGLIACLTAYFFSQNH--VLIVVILLIMG---SLIYAPLT 365
Cdd:cd17321   204 LQAGLALLPLALAMLVAAPLAGRLADRF-GPRLVLVAGLLLTAVGLLLLALLGADSsvWLLLPGLVLLGlglGLFATPLT 282
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2532542707 366 LVGLmvnEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVS 408
Cdd:cd17321   283 NAAL---SSVPKEKAGAASGILNTARQL-GGALGVALLGALLT 321
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
31-436 1.03e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.59  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIirliFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17489     1 ILLANFFFFLSFYL----LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRG---AIYSIWSSAHNA-GAFACVAIVQFATFLFtdsir 186
Cdd:cd17489    77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGegiGYYGLATTLAMAlGPALGLFLYQHLGFAV----- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 187 dVFYTASAVAIIIGIFILLVgsdrpttvglpsiteytgdviqldtgEENNKEVSSLSLPQIFMKYILNNKMVWAITLTSM 266
Cdd:cd17489   152 -LFIVAAVLALLALLLVFLV--------------------------KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILF 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 267 FLYLVRYGIMSWIPSYLVQKGFSpdfAKWLV-GIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAYFFSQN 345
Cdd:cd17489   205 LASIAYGAISTFLPLYAAERGIS---NAGLFfTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPW 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 346 HVLIVVILLIMGSLIYAPlTLVGLMVNEAVP-KFAVGSSTGFMGFfqyIFGETLATALIGILVSKFGWvaSNTVLYAAAF 424
Cdd:cd17489   282 MLLLAAVLYGLGFGLLFP-ALQALAVDLVPPhRRGAANGTFFIFF---DLGIGLGGLLLGLVAELFGY--RAMFLLAAVV 355
                         410
                  ....*....|..
gi 2532542707 425 IALFLLIYILIR 436
Cdd:cd17489   356 VLLALVLYIFLL 367
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
43-434 1.54e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 46.78  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  43 YIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIF--LGSTQNFYV 120
Cdd:cd17380    12 YADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 121 MMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFatFLFTDSIRDVFYTASAVAIIIG 200
Cdd:cd17380    92 LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPL--LLEYYGWPSVFYFFGLLGLLWA 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 201 IFILLVgsdrpttvgLPSiteytgdviqldtgeennkevsslslpqifmkyilnnkmVWAITLTSMFLYLVRYGIMSWIP 280
Cdd:cd17380   170 LVWLIY---------LPP---------------------------------------VWAIIVAHFCMNWGFYILLSWLP 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 281 SYLvQKGFSPDFAKWLVGIFE-LSAVPGVILIGAISDLL--KNYRAIV---CIGCVVGLIACLTAYFFSQNHVLIVVILL 354
Cdd:cd17380   202 TYF-HEVLVPLAKGWVFNVVPwLVMFPSSNVAGWLADHLisRGWTVTSvrkLMQSIGFLGPALFLLLLSHTDSFSLALLC 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 355 IMGSLIYAPLTLVGLMVNEA--VPKFAvGSSTGFMGFFQYIFGeTLATALIGILVSKFGWVASntVLYAAAFIALF-LLI 431
Cdd:cd17380   281 MSVALGLSAFSSSGVLVNHQdiAPNYA-GIVFGISNTAGTIPG-IVGVYLTGYILEATGSWSL--VFVLAAVVNLVgAVV 356

                  ...
gi 2532542707 432 YIL 434
Cdd:cd17380   357 FLL 359
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
4-206 5.07e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 45.25  E-value: 5.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707   4 FLKPAPDSKKKVPANKIKSTYIWRQTG-----VLLAICIGYIGYYiirLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGY 78
Cdd:cd17474   171 FLLPEPKEKAKSSSATKLRDLKKALRGrglltFLVSAFLYFFLYF---AFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  79 GISKLFMGALSDKSNPNHY-LAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYS 157
Cdd:cd17474   248 ALGSLFVGRLLKKRFGARRiLVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2532542707 158 IWSSAHNAGafACVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFILLV 206
Cdd:cd17474   328 LYNFVRFLG--QAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
27-219 8.45e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 44.42  E-value: 8.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  27 RQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISA 106
Cdd:COG0477    11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 107 VLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIR 186
Cdd:COG0477    91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL--GWR 168
                         170       180       190
                  ....*....|....*....|....*....|...
gi 2532542707 187 DVFYTASAVAIIIGIFILLVGSDRPTTVGLPSI 219
Cdd:COG0477   169 WIFLINAPLGLLALVLRLRLPESRGLLLALLAL 201
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
257-430 1.05e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 44.09  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 257 MVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIA 335
Cdd:cd17502   168 TILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVG 247
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 336 CLTAYFFSQN-HVLIVVILLIMGSLIYAPLTLVGLM-VNEAVPKFAVGSSTGFMGFFQyifgeTLATAlIGILVSKFGWV 413
Cdd:cd17502   248 AGLLTTLTLDtSKWLLIGYLILLGLGLGIGFQQPLVaVQNAVPPADVGVATATNTFFR-----SLGGT-LGVAITDVFLV 321
                         170
                  ....*....|....*..
gi 2532542707 414 AsnTVLYAAAFIALFLL 430
Cdd:cd17502   322 A--LALAALAFLLSLFL 336
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
32-206 1.45e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 43.71  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  32 LLAICIGYIGYYIIRLIFTTEQTPIMK-AYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPN---HYLAAGLFISAV 107
Cdd:cd17319   181 VWGLALGYFGINYALYGLLTWLPTYLKqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGarrLVIIIGLLLAAV 260
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFlFTDSIRD 187
Cdd:cd17319   261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVD-ATGSYTA 339
                         170
                  ....*....|....*....
gi 2532542707 188 VFYTASAVAIIIGIFILLV 206
Cdd:cd17319   340 AFLFLAAVALLAALLVLLL 358
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
31-138 1.47e-04

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 43.77  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIIRLIFTTEqtpimKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17336     9 CLLGLLQGAVVSYFVSTITTIE-----KRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCF 83
                          90       100
                  ....*....|....*....|....*...
gi 2532542707 111 FLGSTQNFYVMMFLMlvisiaqGMGAAA 138
Cdd:cd17336    84 LLALPHFLFVGQFLL-------GIGSSP 104
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
6-204 1.80e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.57  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707   6 KPAPDSKKKVPANKIKSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAY-HFSTAQIGLILSCFGIGYGISKLF 84
Cdd:cd06174   179 SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLgGLSVAVAGLLLSLFGLAGALGSLL 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  85 MGALSDKSNPNHYL-AAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAh 163
Cdd:cd06174   259 LGLLSDRLIGRKPLlLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTF- 337
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2532542707 164 NAGAFACVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFIL 204
Cdd:cd06174   338 GFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
56-434 2.16e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.34  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMmflmLVISIAQGMG 135
Cdd:cd17504    22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVL----IAGRALQGIG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAA---CQRTVQLWWGKKRRGAIYSIWSSAHNAGA----FACVAIVQFATFlftdsiRDVFYTASAVAIIIGIFILLVgs 208
Cdd:cd17504    98 GAVfplAFALVREEFPPERVPVAQGILSATFGIGAgiglPLGGWIVQHLGW------RWIFWTAAPVAVLLAALVPLI-- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 209 drpttvglpsiteytgdviqldtgeennkevsSLSLpqifmkyiLNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KG 287
Cdd:cd17504   170 --------------------------------DLRL--------LRRRNVLLANITALLAGFGMFMVFQLLPQLLQLpTP 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 288 FSPDFAKWLVGIFELSAVPGVILIGAISDLLKN---YRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLIMG---SLIY 361
Cdd:cd17504   210 TGFGLGITEAGLLLLPGALVMLIAGPLAGRLIArvgPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGiglGLAF 289
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 362 APLTlvgLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKF-GWVASNTVLYAAAFIALFLLIYIL 434
Cdd:cd17504   290 ASLP---NIVVESVPPDRTGIATGMNTVLRTIGS-AIGPAIAGAILTTYtVSITSGGVPTEGAYVLAFLIGAAL 359
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
61-131 3.35e-04

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 42.62  E-value: 3.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2532542707  61 HFSTAQIGLILSCFGIGYGISKLFMGALSDKS-NPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIA 131
Cdd:cd06177    29 GFTGAQIGAVYSTTGIAAIIMPFFLGIIADRFfAAEKVLAVLHLIGAAALFYAATVTDFSVFFWVMLLYSLC 100
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
63-436 3.68e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.60  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  63 STAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFL-----GSTQNFYVMMFLMLVISIAQGMGAA 137
Cdd:cd06173    32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLallalLGSLSLWLLLVLAFLLGIASAFFGP 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 138 ACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIvqfATFLFT-DSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGL 216
Cdd:cd06173   112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPAL---GGLLVAlLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGE 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 217 PSITEYTGDViqldtgeennkevsslslpqIFMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDFAKW 295
Cdd:cd06173   189 SSSLLLRDLR--------------------EGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGL 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 296 LVGIFELSAVPGVILIGAISDLLKNYRAIvcIGCVVGLIACLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAV 375
Cdd:cd06173   249 LLAAFGVGALLGALLLGRLSKRRRRGRLL--LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2532542707 376 PKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGWVAsntVLYAAAFIALFLLIYILIR 436
Cdd:cd06173   327 PDELRGRVFSVYNALNSGAM-PLGALLAGLLADALGLSA---VFLLAGALLLLAALLLLLL 383
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
252-395 7.59e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 41.38  E-value: 7.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 252 ILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVV 331
Cdd:cd17352   179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLL 258
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 332 GLIACLTAYFFSQNHVLIVVILLIMGSLI--YAPLTLVGLMVNEAVPKF--AVGSSTGFMGFFQYIFG 395
Cdd:cd17352   259 ILGLSLLAFPLATTYVGLIVFSVLFGFCSgsYSSLTPVILADLVGLEKLsnAYGLVLLFQGLAALVGP 326
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
252-435 7.80e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.41  E-value: 7.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 252 ILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLLkNYRAIVCIGCV 330
Cdd:cd17503   174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF-GPRLLLLAGLL 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 331 VGLIACLTAYFFS--QNHVLIVVILLIMG---SLIYAPLTLVGLMvneAVPKFAVGSSTGFMGFFQyIFGETLATALIGI 405
Cdd:cd17503   253 LLALGTLLLAFLTpdTSLWLIILPLFIRGlgmGLVFMPLNTLALN---SLPPEQIGDATALFNTIR-QLGGSIGTALLAT 328
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2532542707 406 LVSKFGWVASNTVL-----------YAAAFIALFLLIYILI 435
Cdd:cd17503   329 LLTNRTQFHHSRLSellaqqvqkqaLIIAFNDAFLVSAILL 369
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
29-206 1.08e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  29 TGVLLAICIGYIGYYIIRLIFtteqtpIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAV- 107
Cdd:cd17321   174 VLAAFLLGAALGGLLFLLPLY------LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVg 247
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 --LNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIV----------- 174
Cdd:cd17321   248 llLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLgalltaglsan 327
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2532542707 175 ----------QFATFLFTDSIRDVFYTASAVAIIIGIFILLV 206
Cdd:cd17321   328 lgdsgvaallSAAAAAFAAGFHLAFLVAAALALLAALLALLL 369
MFS_1 pfam07690
Major Facilitator Superfamily;
6-169 1.27e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707   6 KPAPDSKKKVPANKIKSTYIWRQTGVLLAIcIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFM 85
Cdd:pfam07690 177 SKRPKPAEEARLSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLL 255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  86 GALSDKSNPNHYLAAGLFISAVLNI---FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSA 162
Cdd:pfam07690 256 GRLSDRLGRRRRLLLALLLLILAALgllLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTA 335

                  ....*..
gi 2532542707 163 HNAGAFA 169
Cdd:pfam07690 336 GSLGGAL 342
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
302-431 1.59e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 40.52  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 302 LSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIACLTAYFFSQNHVLIVVILLI---MGSLIYAPLTLVGLMVNEavpkf 378
Cdd:COG2270   285 IVAALGALLFGRLDDRIGPKRVIL-VSLVIWIVVCLAAYFLTTALAFWILGLLIglvMGGIQALSRSLLARLIPP----- 358
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2532542707 379 avGSSTGFMGFFQyIFGEtlATALIGILVskFGWV--ASNTVLYAAAFIALFLLI 431
Cdd:COG2270   359 --GREAEFFGLYA-LSGK--AASFLGPLL--FGLVtqLTGSQRLGILSLIVFFVI 406
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
57-139 1.88e-03

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 40.40  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  57 MKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFL--GSTQNFYVMMFLMLVISIAQGM 134
Cdd:cd17382    41 KAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIpiAARVHYGCVIFVRILQGLVEGV 120

                  ....*
gi 2532542707 135 GAAAC 139
Cdd:cd17382   121 TYPAC 125
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
31-434 2.37e-03

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 40.08  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNpnhyLAAGLFISAVLNI 110
Cdd:cd17334     5 VLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVG----LRIGVLIGAALNA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 F--------LGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAG---AFACVAIVQFATF 179
Cdd:cd17334    81 LgsvlkcipLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGcaiGFLLPPVVVPPPK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 180 LFTDSIRDVFYTASAVAIIIGIFILLVGSDRPTTVglPSITeytgdviqldTGEENNKEVSSLSLpQIFMKYILNNKMVW 259
Cdd:cd17334   161 GTKKEFGAVFYGEFGFACLLLALVLALFPPKPKYP--PSAA----------SARQQNSEHVILEL-QKSISELLRNEPFV 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 260 AITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTA 339
Cdd:cd17334   228 LLAVAFSIMMGVFAGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFF 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 340 YFFSQNHVLIVVILlimgsLIYAPLTLVGLMVNEAVP---KFAV--------GSSTGFMGFFQYIFGeTLATALIGILVS 408
Cdd:cd17334   308 MLLVDRYGLPYVTL-----AFYLLCGLLGFFQNSMVPimfELAVeltypvpeSVSTGVLTALANLFS-FLLMLVFSELLG 381
                         410       420
                  ....*....|....*....|....*.
gi 2532542707 409 KFGWVASNTVLYAAAFIALFLLIYIL 434
Cdd:cd17334   382 PTPTESKYLLWFILCTVGSCLGALFF 407
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
258-447 2.46e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.83  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 258 VWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGcvVGLIACL 337
Cdd:cd17370     1 VWLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILG--YGLSALA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 338 TAYFFSQNHVLIVVILLIMGSL---IYAPLTLVglMVNEAVPKFAVGSSTGFMGFFQyIFGETLAtALIGILVSKFGWVA 414
Cdd:cd17370    79 KPLLALAGSWQLVLLLRILERLgkgIRTPPRDA--LLADATPPSGRGKAFGLHRALD-TLGAVLG-PLLAALLLYLLGGN 154
                         170       180       190
                  ....*....|....*....|....*....|....
gi 2532542707 415 SNTVLYAAAFIALF-LLIYILIREKKDIQEEVKE 447
Cdd:cd17370   155 YRTIFLLAAIPALLaLLILLFVVKEYPRPPKLRK 188
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
270-339 2.90e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 39.95  E-value: 2.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 270 LVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIgcVVGLIACLTA 339
Cdd:PRK11551  234 IVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLI--YAGILASLAA 301
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
56-356 3.28e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 39.54  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGS-TQNFYVMMFLMLVISIAqGM 134
Cdd:cd17341    25 IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALaVSSYWGLLVLGFLLGFA-GA 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 GAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGafacVAIVQFATFLFTDSI---------RDVFYTASAVAIIIGIFILL 205
Cdd:cd17341   104 NFASGQPWASFWFPKEKIGGAAGGIAGAGNMG----VAVSQLLAPLIAGAIvfdggfvgwRNAFFVPGILLAIAAVLVLL 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 206 VGSDRPTTvglpsiteytgdviqldtgeennKEVSSLSLPQifMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLV- 284
Cdd:cd17341   180 FGDDLPTG-----------------------KASALEFLKV--QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKt 234
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 285 QKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYR--AIVCIGCVVGLIACltAYFFSQNHVLIVVILLIM 356
Cdd:cd17341   235 RFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRrlWWLFIVMTIGAALL--SLSLPTSGTNLVLFLALF 306
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
56-433 7.28e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 38.33  E-value: 7.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVisiaQGMG 135
Cdd:cd17320    25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFL----QGLG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAAC----QRTVQLWWGKKRRGAIYSIwssahnAGAFACVAIV------QFATFLFtdSIRDVFYTASAVAIIIGIFILL 205
Cdd:cd17320   101 AAAGsvvaRAIVRDLYSGAELAKIFSL------LMMILAIAPAlapllgGLLLLFF--GWRAIFVFLALLGLLLLLLVLL 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 206 VgsdrpttvgLPSiteytgdviqldTGEENNKEVSSLSLPQIFmKYILNNKMVWAITLTSMFLYLvryGIMSWIPS---- 281
Cdd:cd17320   173 F---------LPE------------TLPEEKRKPLLSSLLRAY-KRVLKNRRFLGYALALGLSFA---GLFAYLAAapfi 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 282 YLVQKGFSPDfakwLVGIFELSAVPGVILIGAISD-LLKNYRAIVCIGCVVGLIACLTAyffsqnhVLIVVILLIMGSLI 360
Cdd:cd17320   228 YIEQLGLSPA----QFGLLFALNAIALILGSLLNGrLVRRFGPRRLLRLGLLLLLAAAL-------VLLLAALLGGLSLW 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 361 Y--APLTLVGLMVNEAVP----------KFAVGSSTGFMGFFQYIFGeTLATALIGILVSkFGWVASNTVLYAAAFIALF 428
Cdd:cd17320   297 PlvAPLFLIFFGFGLIFPnatslalepfPHVAGTASALLGFLQFLIG-ALAGALVGLLPN-GTALPMGLLILVLGLLALL 374

                  ....*
gi 2532542707 429 LLIYI 433
Cdd:cd17320   375 LLILL 379
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
60-435 8.92e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 38.37  E-value: 8.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707  60 YHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIF--LGSTQNFYVMMFLMLVISIAQGMGAA 137
Cdd:cd17318    51 FDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLtpLAARGGYGALIVLRILQGLAQGVTFP 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 138 ACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFacvaIVQFATFLFTDSIR--DVFYTASAVAIIIGIFILLvgsdrpttvg 215
Cdd:cd17318   131 AMHALWAKWAPPLERSRLTSIAYSGSQFGTV----IAMPLSGFLCESLGwpSIFYIFGGLGLLWCLLWFF---------- 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 216 lpsiteytgdviqldtgeennkevssLSLPqifmkyilnnkmVWAITLTSMFLYLVRYGIMSWIPSYLvQKGFSPDFAKw 295
Cdd:cd17318   197 --------------------------LVLP------------VWAIVVAHFGHNWGFYTLLTELPTYM-SDVLHFNIKS- 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 296 lVGIfeLSAVPGV------ILIGAISDLLKNY--------RAIVCIGCVVGLIACLTAY-FFSQNHVLIVVILLImgSLI 360
Cdd:cd17318   237 -NGF--LSSLPYLamwicsIVGGYLADWLRSRgilstttvRKLFTSIGFLGPGVFLIALgYLGSNATLAVVFLTL--SVG 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 361 YAPLTLVGLMVN--EAVPKFAvGSSTGFMGFFQYIFGeTLATALIGILVSK----FGWvasNTVLYAAAFIALFLLIYIL 434
Cdd:cd17318   312 LSGACYSGFLVNhlDLAPNYA-GTLMGITNTAATIAG-IISPLIVGAIVKNdqtiGQW---RIVFFISAAIYILGAIFYL 386

                  .
gi 2532542707 435 I 435
Cdd:cd17318   387 I 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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