|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
28-434 |
2.77e-143 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 415.49 E-value: 2.77e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 28 QTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAV 107
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLG----STQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQF-ATFLFT 182
Cdd:cd17345 81 INILIGfvpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLgLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 183 DSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLDTGEENNKEvssLSLPQIFMKYILNNKMVWAIT 262
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQE---LSAWEIFVKYVLKNKLLWYIA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 263 LTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL-KNYRAIVCIGCVVGLIACLTAY 340
Cdd:cd17345 238 IANVFVYLVRYGILDWAPTYLSEvKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfKGRRAPTGIIFMILVIVALIVY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 341 FFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGILVSKFGWVASNTVLY 420
Cdd:cd17345 318 WLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVLL 397
|
410
....*....|....
gi 2532542707 421 AAAFIALFLLIYIL 434
Cdd:cd17345 398 ASCILAIIFLALVA 411
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
1-448 |
4.30e-91 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 283.52 E-value: 4.30e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 1 MFSFLKPAPdSKKKVPANKIKSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQtPIMKAYHFSTAQIGLILSCFGIGYGI 80
Cdd:PRK11273 1 MLSIFKPAP-HKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAM-PYLVEQGFSRGDLGFALSGISIAYGF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 81 SKLFMGALSDKSNPNHYLAAGLFISAVLNIFLG----STQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIY 156
Cdd:PRK11273 79 SKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGfvpwATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 157 SIWSSAHNAGAFACVAIVQFATFLFTDsIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQlDTGEENN 236
Cdd:PRK11273 159 SVWNCAHNVGGGLPPLLFLLGMAWFND-WHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPD-DYNEKHE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 237 KEvssLSLPQIFMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAIS 315
Cdd:PRK11273 237 QE---LTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFALDKSSWAYFLYEYAGIPGTLLCGWMS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 316 D-LLKNYRAIVCIGCVVGLIACLTAYFFSQ--NHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQY 392
Cdd:PRK11273 314 DkVFRGNRGATGVFFMTLVTIATIVYWLNPagNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGY 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 2532542707 393 IFGETLATALIGILVSKFGWVASNTVLYAAAFIALFLLIYILIREKKDIQEEVKEA 448
Cdd:PRK11273 394 LGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQKR 449
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
37-412 |
1.81e-78 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 248.44 E-value: 1.81e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 37 IGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQ 116
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 117 NFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAfACVAIVQFATFLFTDSIRDVFYTASAVA 196
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGG-GLLPPLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 197 IIIGIFILLVGSDRPTTVGLPSITEYTGDviqlDTGEENNKEVSSLSLPQIFMKYILNNKMVWAITLTSMFLYLVRYGIM 276
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNE----EPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGIL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 277 SWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISD-LLKNYRAIVCIGCVVGLIACLTAYF--FSQNHVLIVVI 352
Cdd:TIGR00881 237 DWSPLYLTQeKGFSKEKASWAFTLYELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVYWlnPAANPLMDLIC 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 353 LLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGW 412
Cdd:TIGR00881 317 LFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGG-ILAGLPLGYLADGFGW 375
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
33-447 |
2.78e-64 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 214.14 E-value: 2.78e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 33 LAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVL---- 108
Cdd:PRK09556 32 LVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICmlgf 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 109 NIFLGSTQNFYVMMFLMLVIS-IAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQF-ATFLFTDSIR 186
Cdd:PRK09556 112 GASLGSGSVSLGLMIALWALSgFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWgANYFFDGHVI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 187 DVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLDTGEENNKEVSSLslpQIFMKYILNNKMVWAITLTSM 266
Cdd:PRK09556 192 GMFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETESTDMTKW---QIFVEYVLKNPVIWLLCFANI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 267 FLYLVRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAYFFSQN 345
Cdd:PRK09556 269 FLYIVRIGIDNWSPVYAFQElGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRRALVACIALALIIFTLGVYQHATS 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 346 HVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGILVSKF------------GWV 413
Cdd:PRK09556 349 EYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDSFAKVGLGMIADPTkngtpifgytltGWA 428
|
410 420 430
....*....|....*....|....*....|....
gi 2532542707 414 ASNTVLYAAAFIALFLLIYILIREKKDIQEEVKE 447
Cdd:PRK09556 429 GTFAALDIAAIGCICLMAIVAVMEERKIRREKKI 462
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
31-431 |
2.40e-54 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 185.17 E-value: 2.40e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFacVAIVQFATFLFTDSIRDVFY 190
Cdd:cd17312 84 FMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGI--LAPILAASLASYYGWRAAFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVGSDRPttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYL 270
Cdd:cd17312 162 VPGIVGLVVAIILFFFLRDSP--------------------------------------------PYVWVLSLAYAFVYI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL-KNYRAIVCIGCVVGLIACLTAYFFS-QNHV 347
Cdd:cd17312 198 VRYACLDWGPLYLYEvKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMTLSLALFWFFpHNKL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 348 LIVVILLIMGSLIYAPLTLVGLMVNEAV-PKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGWVASNTVLYAAAFIA 426
Cdd:cd17312 278 LSIVLLFLIGFFVGGPINLIGGAAAQDIgRKEAAGTATGFVGLFGYLGA-SLAGLPLGYIIDHYGWSTVFYFLISAALLS 356
|
....*
gi 2532542707 427 LFLLI 431
Cdd:cd17312 357 VLLLL 361
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
19-433 |
4.38e-52 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 181.06 E-value: 4.38e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 19 KIKSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYL 98
Cdd:PRK11663 12 EIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFM 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 99 AAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFAT 178
Cdd:PRK11663 92 GIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 179 FLFtdSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLdtgeENNKEVSSLSLPQIFMKYILNNKMV 258
Cdd:PRK11663 172 LHY--GWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALEL----AQQQEGAGLSRKEILTKYVLLNPYI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 259 WAITLTSMFLYLVRYGIMSWIPSYLV-QKGFSPDFAKWLVGIFELSAVPGVILIGAISD-LLKNYRAIVCIGCVVGLIAC 336
Cdd:PRK11663 246 WLLSFSYVLVYVVRAAINDWGNLYMSeTLGVDLVTANSAVSMFELGGFIGALVAGWGSDkLFNGNRGPMNLIFAAGILLS 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 337 LTAYFF--SQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWVA 414
Cdd:PRK11663 326 VGSLWLmpFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GAALSGYPLAKVLEIWHWTG 404
|
410 420
....*....|....*....|
gi 2532542707 415 SNTVL-YAAAFIALFLLIYI 433
Cdd:PRK11663 405 FFVVIsIAAGISALLLLPFL 424
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-439 |
3.61e-49 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 171.59 E-value: 3.61e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 21 KSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAA 100
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 101 GLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFL 180
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 181 FtdSIRDVFYTASAVAIIIGIFillvgsdrpttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnkMVWA 260
Cdd:COG2271 161 F--GWRAAFLILGLPGLLLALL------------------------------------------------------RFWL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 261 ITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTA 339
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 340 YFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGWVASNTVL 419
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG-ALGPLLVGYLLDATGYQAAFLLL 343
|
410 420
....*....|....*....|
gi 2532542707 420 YAAAFIALFLLIYILIREKK 439
Cdd:COG2271 344 AALALLAALLALLLLRETRK 363
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
31-431 |
3.63e-39 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 144.86 E-value: 3.63e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17488 4 ILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFY 190
Cdd:cd17488 84 LFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTY--GWRAGMY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVGSDRPttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYL 270
Cdd:cd17488 162 VPGIIAILMGIVLCWRLRDRP--------------------------------------------PYIWLLAFCYVLVYV 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL-KNYRAIVCIGCVVGLIACLTAYFFSQNH-- 346
Cdd:cd17488 198 VRTAINDWGNLYLSEtHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLfKGNRGPMNLIFALGLLVSVGALWLVPVHsy 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 347 VLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYiFGETLATALIGILVSKFGWVASNTVLYAAAFIA 426
Cdd:cd17488 278 WLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAY-LGAALAGYPLAKVIESWGWSGFFIVISIAAAIS 356
|
....*
gi 2532542707 427 LFLLI 431
Cdd:cd17488 357 GLLLL 361
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
28-430 |
5.40e-28 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 114.74 E-value: 5.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 28 QTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAV 107
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHN-AGAFACVaivqFATFLFTD-SI 185
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNlAGSLGPI----LATLLALSyGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 186 RDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEytgdviqldtgEENNKEVSSLSLPQIFMKYILNNKMVWAITLTS 265
Cdd:cd17343 157 RSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE-----------EESKGKKKKSPRGESTLKELLLSPFLWLLSLGY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 266 MFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLL---------KNYRAIVCIGCVVGLIA 335
Cdd:cd17343 226 LVVFGVKTAVTDWGQLFLIQdKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAvakhgsssrGNPRMPLALVFMAGLTV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 336 CLTAYFF----SQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYiFGETLATALIGILVSKFG 411
Cdd:cd17343 306 SLHLFRVhitsDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAAN-VGGVLAGLPFSYIAKHYD 384
|
410
....*....|....*....
gi 2532542707 412 WVASNTVLYAAAFIALFLL 430
Cdd:cd17343 385 WRTAFLLLEILCAITVVIL 403
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
35-431 |
2.95e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 112.13 E-value: 2.95e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 35 ICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGS 114
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 115 TQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFTDSIRDVFYTASA 194
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 195 VAIIIGIFILLVGSDRPttvglpsiteytgdviqldTGEENNKEVSSLSLPQIFMKYILNNKMVWAITLTSMFLYLVRYG 274
Cdd:cd06174 161 LALLAAILLLLVVPDPP-------------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 275 IMSWIPSYLVQKG-FSPDFAKWLVGIFELSAVPGVILIGAISDLLKNyRAIVCIGCVVGLIACLTAYFFSQNHVLIVVIL 353
Cdd:cd06174 222 FSTLLPLFLLDLGgLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG-RKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 354 LIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGILVSKFGWVASNTVLYAAAFIALFLLI 431
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
22-396 |
9.10e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 104.67 E-value: 9.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 22 STYIWRQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAG 101
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 102 LFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLF 181
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 182 tdSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEytgdviqldtgeennkevsslslpqifMKYILNNKMVWAI 261
Cdd:COG2814 162 --GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS---------------------------LRELLRRPRLLLL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 262 TLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIvcIGCVVGLIACLTAY 340
Cdd:COG2814 213 LLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL--LIGLLLLALGLLLL 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2532542707 341 FFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGE 396
Cdd:COG2814 291 ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
31-435 |
1.95e-24 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 103.80 E-value: 1.95e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17319 4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFY 190
Cdd:cd17319 84 LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF--GWRWAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVGsdrpttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYL 270
Cdd:cd17319 162 IEGLLGLLLAVLWWFYL------------------------------------------------RQVWGLALGYFGINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNY-RAIVCIGCVVGLIACLTAYFFSQNHVL 348
Cdd:cd17319 194 ALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGaRRLVIIIGLLLAAVGLLLAYLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 349 IVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGwvASNTVLYAAAFIALF 428
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL-GGFVAPLLIGYLVDATG--SYTAAFLFLAAVALL 350
|
....*..
gi 2532542707 429 LLIYILI 435
Cdd:cd17319 351 AALLVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-393 |
4.27e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.50 E-value: 4.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 31 VLLAICIGYIGYYIIRLIFTTeqtPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPL---LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFY 190
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLdtgeennkevsslslpqifmKYILNNKMVWAItLTSMFLYL 270
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW--------------------KALLRDPVLWLL-LALLLFGF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAI-VCIGCVVGLIACLTAYFFSQNHVLI 349
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLlLALLLLILAALGLLLLSLTLSSLWL 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2532542707 350 VVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYI 393
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-439 |
4.44e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 100.34 E-value: 4.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 27 RQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISA 106
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 107 VLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIR 186
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF--GWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 187 DVFYTASAVAIIIGIFILLVGSDRPttvglpsiteytgdviqldtgeENNKEVSSLSLPQIfmKYILNNKMVWAITLTSM 266
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPP----------------------AGAAAAAKASLRDQ--LEALRDPRFWLLSLLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 267 FLYLVRYGIMSWIPSYLV-QKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIACLTAYFFSQN 345
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL-IVFALMALGLLLLALALGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 346 HVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFG-WVASNTVLYAAAF 424
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGG-FLGPLLFGALLDATGsYTAAFLVFAVLAL 373
|
410
....*....|....*
gi 2532542707 425 IALFLLIYILIREKK 439
Cdd:COG2223 374 VALVLTLLLYRRPRR 388
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-436 |
2.26e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.25 E-value: 2.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 31 VLLAICIGYIGYYIIRLIFTteqtPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILP----LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFY 190
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL--GYRAPFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 191 TASAVAIIIGIFILLVgsdrpttvgLPsiteytgdviqlDTGEENNKEVSSLSLPQIFMKYILNNKMVWAITLTSMFLYL 270
Cdd:cd17325 155 VCAALALLALVLALLL---------LP------------EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 271 VRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKnyRAIVCIGCVVGLIACLTAYFFSQNHVLI 349
Cdd:cd17325 214 AFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG--RKPLILIGLLLSAVALLLLPLATSFWLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 350 VVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWvaSNTVLYAAAFIALFL 429
Cdd:cd17325 292 LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGF--ATPFLAAAALLLLAA 368
|
....*..
gi 2532542707 430 LIYILIR 436
Cdd:cd17325 369 VLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
55-436 |
1.12e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 90.32 E-value: 1.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 55 PIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGM 134
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 GAAACQRTVQLWWGKkRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFYTASAVAIIIGIFILLVGSDRPTTV 214
Cdd:COG2807 123 GNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAAL--GWRGALAVWALLALLALLLWLPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 215 GLPSiteytgdviqldtgeennKEVSSLSLpqifmkyiLNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAK 294
Cdd:COG2807 200 AAAP------------------AAASLRSL--------WRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 295 WLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILL--IMGSLIYAPLTLVGLMVN 372
Cdd:COG2807 254 LLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLglGQGGLFPLALTLIGLRAR 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2532542707 373 EAVpkfAVGSSTGFMGFFQYIFGeTLATALIGILVSKFG-WVASNTVLyAAAFIALFLLIYILIR 436
Cdd:COG2807 334 TPA---EAAALSGMAQSVGYLLA-ALGPLLVGALHDATGsWTAALLLL-AALAVLMLVAGLLAGR 393
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-431 |
1.39e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 86.84 E-value: 1.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGM- 134
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAf 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 ---GAAACQRTvqlwwGKKRRGAIYSIWSSAHNAGaFACVAIvqFATFLFTDSIRDVFYTASAVAIIIGIFILLVGSDRP 211
Cdd:cd17478 102 hpeGARLASQA-----AGGRRGLAMSIFSVGGNLG-FALGPL--IAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 212 ttvgLPSITEYTGDVIQLDTgeennkevsslslpqifmkYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPD 291
Cdd:cd17478 174 ----KPEAKKAAAKSSARST-------------------LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 292 FAKWLVGIFELSAVPGVILIGAISDLLkNYRAIVCIGCVVGLIacLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMV 371
Cdd:cd17478 231 FAGLLLSLFLFAGAIGTLIGGPLSDRF-GRRRVIIASLLLAAP--FLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 372 NEAVPKFAVGSSTGFMGFFQYIFGetLATALIGILVSKFGWVASNTVLYAAAFIALFLLI 431
Cdd:cd17478 308 QELLPGNVGLASGLMMGLSFGLGG--IGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
56-439 |
3.22e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 82.98 E-value: 3.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMG 135
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRTVqLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFL-FTDSIRDVFYTASAVAIIIGIFILLvgsdrpttV 214
Cdd:COG0738 114 DVAANPYV-AALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLgLSLSWHLPYLILAVLLLLLALLFLR--------S 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 215 GLPSITEYTGDVIQLDTGeennkevsslslpqifMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFA 293
Cdd:COG0738 185 KLPEIEEEEEEAAGSAAS----------------LKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 294 KWLVGIFELSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIACLTAYFFSQNHVLIVVILLI--MGSLIYAplTLVGLMV 371
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLR-LSALLAAVGLLLALLAPGPWLALIGLALVglGLSLMFP--TIFSLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 372 nEAVPKFAVGSSTGFMGFfqYIFGETLATALIGILVSKFGWVASNTVLyAAAFIALFLLIYILIREKK 439
Cdd:COG0738 326 -DGLGKRTAAAVSAVLIM--GIVGGAIGPPLIGFLADAFGLRAAFLVP-LVCYLLILLLALALKRKRR 389
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
32-431 |
3.81e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 82.60 E-value: 3.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 32 LLAICIGYIGYYIIRLIftteqTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIF 111
Cdd:cd17324 6 LAAFAIGTTEYVIQGLL-----PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 112 LGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFYT 191
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL--GWRAAFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 192 ASAVAIIIGIFILLVgsdrpttvgLPSITEytgdviqldtgeenNKEVSSLSLPQIFMkyILNNKMVWAITLTSMFLYLV 271
Cdd:cd17324 159 IAVLALLAALLLWRL---------LPSLPP--------------KKPGSLGLLSSLLL--LLRNPRLRLAYLITFLLFGG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 272 RYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTayFFSQNHVLIV 350
Cdd:cd17324 214 FFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLT--LLGPSPLLLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 351 VILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYifGETLATALIGILVSKFGWVASNTVLYAAAFIALFLL 430
Cdd:cd17324 292 VGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNL--GGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
.
gi 2532542707 431 I 431
Cdd:cd17324 370 L 370
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
59-431 |
6.74e-16 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 78.82 E-value: 6.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 59 AYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVIsiaqGMGAAA 138
Cdd:cd17475 25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV----GAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 139 CQ----RTVQLWWGKKRRGAIYSIWSSAHNAGAFacVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFILLVGSDRPTTV 214
Cdd:cd17475 101 VQpgggRAIMRWFPPRERGLAMGIRQTGVPLGGA--LAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAAS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 215 GLPSITeytgdviqldtgeenNKEVSSLSLPqifmkyiLNNKMVWAITLTSMFLYLVRYGIMSWIPSYLV-QKGFSPDFA 293
Cdd:cd17475 179 AATESA---------------STLLRSLKEV-------LRNRDVWLIAIAGALLVAPQFALLTFLLLFLHdHLGLSVVAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 294 KWLVGIFELSAVPGVILIGAISDLL--KNYRA-IVCIGCVVGLIACLTAYFFSQNHVLIVVILLI---MGSLIYAPLTLV 367
Cdd:cd17475 237 GALLAVAQLGGALGRIGLGRVSDRVfgGRRRPvLVITAAIAAAALLVLSLLSPGTPLWLLVLLLIllgLFAIGWNGLYLT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 368 glMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKfgwvasnTVLYAAAFIALFLLI 431
Cdd:cd17475 317 --LVAESAGPEQAGTALGLANTINFI-GIAIGPPLFGLLVDA-------THSYAPAWLALALLL 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
31-429 |
9.29e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 75.39 E-value: 9.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQ-GMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQfaTFLFTDSIRDVF 189
Cdd:cd17355 84 LLALATSLWQLYLLWGLLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGA--ALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 190 YTASAVAIIIGIFILLVGSDRPTTVGLPSITeytgdviqldtgeennkeVSSLSLPQIFMKYILNNKMVWAITLTSMFLY 269
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPADLALRAYD------------------DASPASPGSTLKEALRSASFWLLALAFFLCG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 270 LVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLkNYRAIVCIGCVVGLIACLTAYFFSQNHVLI 349
Cdd:cd17355 224 FAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRY-SPRRLLAASYALRALGLALLLLLPFPPLAL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 350 VVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMgFFQYIFGETLATALIGILVSKFG-----WVASNTVLYAAAF 424
Cdd:cd17355 303 LLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLV-FAPHQLGSALGPWLGGLLYDRTGsytaaWALAVALGLIAAL 381
|
....*
gi 2532542707 425 IALFL 429
Cdd:cd17355 382 LVLPI 386
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
57-433 |
2.13e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 71.05 E-value: 2.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 57 MKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGA 136
Cdd:cd17477 23 LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 137 AACQRTVQLWWGKKRRGAIYSIWSSAHNAGafacVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFILLVGSDRPTTvgl 216
Cdd:cd17477 103 VVSESWLNALATNENRGRVLGLYSTVLGLG----FALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEI--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 217 psiteytgdviqldtgeennKEVSSLSLPQIFMKYILnnkmvwaiTLTSMFLY-LVRYGIMSWIPSYLVQKGFSPDFAKW 295
Cdd:cd17477 176 --------------------EEAESISLRRLLRIAPL--------ALLGAFVAgFLEGAFYSLLPLYGLRLGLSVAQAAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 296 LVGIFELSAVPGVILIGAISDLLKNYRAIVCIgCVVGLIACLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAV 375
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLADRFDRRRVLLGC-ALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRL 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 376 PKFAVGSSTGFMGFFqYIFGETLATALIGILVSKFGwvaSNTVLYAAAFIALFLLIYI 433
Cdd:cd17477 307 PGDELVAANAALLLL-YGLGSVIGPLLAGALMDAFG---PHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
58-411 |
4.80e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.17 E-value: 4.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 58 KAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAA 137
Cdd:cd17329 28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 138 ACQRTVQLWWGKKRRGAIYSIWSSAHNAGAfACVAIVqfATFLFTDSIRDVFyTASAVAIIIGIFILLVGSDRPTTVGLP 217
Cdd:cd17329 108 ASEAMIADVTTPENRTRAFSLLYWAINLGV-AIGPLL--GGLLLLYSFRLLF-LAAAVLFLLAALVLLFLLPETRPKRRA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 218 SITEYTGDVIQLdtgeennkevsslslpqifmkyILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAkwLV 297
Cdd:cd17329 184 AEKTEILRGYKI----------------------VLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL--LG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 298 GIFELSAVPGVILIGAISDLLKNYRAIVCIG-CVVGLIACLTAYFFSQN--HVLIVVILLIMGSLIYAPltlvglMVNEA 374
Cdd:cd17329 240 LLLALNALLIVLLQFPVARLVERFRLRKILMiGILLFAIGFAVLAFANTlaVLILAMIVLTLGEMLVFP------AVQTL 313
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2532542707 375 VPKFAVGSSTG-FMGFFQ--YIFGETLATALIGILVSKFG 411
Cdd:cd17329 314 VAALAPPDKRGsYMGFYAlaWGLGRAIGPLVGGLLLDLLG 353
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
47-434 |
4.95e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 64.25 E-value: 4.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 47 LIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLML 126
Cdd:cd17371 16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 127 VISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIvqfATFLFTDSI-----RDVFYTASAVAIIIgI 201
Cdd:cd17371 96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLL---AALLFPLLPpeiawRVLFLLGALPALLV-L 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 202 FILLVGSDRPttvglpsiteytgdvIQLDTGEENNKEVSSLSLPQIFMKYILNNKMVWaiTLTSMFLYLVRYGIMSWIPS 281
Cdd:cd17371 172 FIRRFVKEPP---------------QWQAARAARRHFADRPSLRELFSPPLLRTTLLA--SLLATGALGGYYGITTWLPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 282 YL-VQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNyRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLIMGSLI 360
Cdd:cd17371 235 YLtGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGR-RNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFA 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2532542707 361 YAPLTLVGLMVNEAVPKFAVGSSTGFMgffqYIFGE---TLATALIGILVSKFGWVASNTVLYAAAFIALFLLIYIL 434
Cdd:cd17371 314 SGPFSGMGAYLTELFPTAVRATAQGFC----YNVGRiigALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
56-433 |
1.40e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYvmmfLMLVISIAQGMG 135
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA----LLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRT-----VQLWWGKKRRGAIySIWSSAHNAGAFACVAIvqfATFLFTDSIRDVFYtASAVAIIIGIFILLVGSDR 210
Cdd:cd17474 101 AAGLGPLaltliGDLFEGGERAKAM-GLYEAALGLGIAVGPLL---GGLLAAISWRYPFF-LLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 211 PTTVGLPSITEYTGDviqldtgeennkevsslslpqifMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQK-GFS 289
Cdd:cd17474 176 PKEKAKSSSATKLRD-----------------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 290 PDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVgLIACLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGL 369
Cdd:cd17474 233 PIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLL-YALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 370 MVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWVASNTVLYAAAFIALFLLIYI 433
Cdd:cd17474 312 LVTELAPEEERGTASSLYNFVRFL-GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
252-369 |
1.41e-10 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 1.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 252 ILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVV 331
Cdd:cd17339 192 VWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVL 271
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2532542707 332 GLIACLTAYFFSQNHVLIVVILLI--MGSLIYAPLTLVGL 369
Cdd:cd17339 272 FIIGVLGLLFAPTALALLWAVLLGlgGGAAFSLALTLISL 311
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
56-434 |
5.20e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 60.80 E-value: 5.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQG-M 134
Cdd:cd17333 22 LEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGiL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 GAAACQRTVQLWwgKKRRGAIYSIWSSAHNAGAFACVAIvqfATFLFTDSIR--DVFYTASAVAIIIGIFILLVGSDRpt 212
Cdd:cd17333 102 DTGANTFVGALF--EESSATRLNVLHGFFGLGALIGPLI---ATSLLTSELSwsWAYLIIGLIYLLLAILILLTLFPE-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 213 tvglpsiTEYTGDVIQLDTGEennkevsslslpQIFMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPD- 291
Cdd:cd17333 175 -------LPSARNPQQSVGAF------------SASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDg 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 292 FAKWLVGIFELSAVPGVILIGAISDLLKnYRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLImgSLIYAPLTLVGLMV 371
Cdd:cd17333 236 LAGYLLSGFWVGITIGRLLGGPISRRIK-PHTLLVLSGSGALLGLLILLLAPTLVVGLVATALL--GLFMAALFPTILSL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2532542707 372 NEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWVAsnTVLYAAAFIALFLLIYIL 434
Cdd:cd17333 313 GISNLPYAKGKGTSVLLAAGSI-GGAIIPFIMGFIAEAVGIQT--AMLLITILYAIIFVLALL 372
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
6-205 |
2.28e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.74 E-value: 2.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 6 KPAPDSKKKVPANKIKSTYIW--RQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKL 83
Cdd:cd17325 174 PRPPPNKRAVSAARLRSGLRLllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQP 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 84 FMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAH 163
Cdd:cd17325 254 PAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF 333
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2532542707 164 NAGAFACVAIVQFATFLFtdSIRDVFYTASAVAIIIGIFILL 205
Cdd:cd17325 334 SLGMVLGPLLGGFLYDAF--GFATPFLAAAALLLLAAVLFLL 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
33-448 |
3.80e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.37 E-value: 3.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 33 LAICIGYIGYYIIRLIFTTEQtpimkaYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNH-----YLAAGLFISAV 107
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDV------LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLGSTQNFYVMMFL--MLVISIAQGMGAAACQrtvQLWWG--------KKRRGAIYSIWSSAHNAGAFACVAIVQFA 177
Cdd:COG2211 94 SFVLLFTAPDLSPTGKLiyALVTYLLLGLAYTLVN---IPYSAlgaeltpdYEERTRLSSWRFAFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 178 TFLFTDSIRD-VFYTASAVAIIIGIFILLVGsdrpttvglpsiteytgdviqLDTGEENNKEVSSLSLPQIFmKYILNNK 256
Cdd:COG2211 171 VAAFGGDAALgYRLTALIFAVLGLLAFLLTF---------------------FGTKERPVPEEEKVSLKESL-KALLKNR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 257 MVWAITLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIA 335
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI-IGLLLAALG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 336 CLTAYFFSQNHV-LIVVILLIMGSLIYAPLTLVGLMVNEAVP-------KFAVGSSTGFMGFFQYIfGETLATALIGILV 407
Cdd:COG2211 308 LLLLFFLGPGNLwLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKL-GQALAGALAGLLL 386
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 408 SKFGWVASNT-------------VLYAAAFIALFLLIYILIREKKDIQEEVKEA 448
Cdd:COG2211 387 ALFGYVAGAAqspsaltgirllfFLLPAVLLLLAALLLLFYPLTRERHAEIRAE 440
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
58-447 |
1.66e-08 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 56.68 E-value: 1.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 58 KAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFL--GSTQNFYVMMFLMLVISIAQGMG 135
Cdd:TIGR00894 69 PNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSV 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRTVQLWWGKKRRGAIYSIwssahnagafaCVAIVQFATFLF---TDSIRD-------VFYTASAVAIIIGIFILL 205
Cdd:TIGR00894 149 SPATHKIIVKWAPPKERSRLLGM-----------STSGFQLGTFIFlpiSGWLCEswggwpmIFYVFGIVGCAWSLLWFV 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 206 VGSDRPTTVglPSITEYTGDVIqldtGEENNKEVSSLSLPQIFmKYILNNKMVWAITLtsmflylvryGIMSWIPSYLVQ 285
Cdd:TIGR00894 218 FPADDPSIH--PCISKFEKKYI----NSSLQGQKGSTRQSLPI-KAIPKSLPVWAIWF----------AIFGHFWLYTIL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 286 KGFSPDFAKWLVG--IFE---LSAVPGV------ILIGAISDLLKN--------YRAIVC-IGCVVGLIACLTAYFFSQN 345
Cdd:TIGR00894 281 PTYLPTFISWVLRvsGKEnglLSSLPYLfawlcsIFAGYLADFLKSsktlsltaARKIFNgIGGLGPGIFAYALPYLSAA 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 346 HVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFA--VGSSTGFMGFFQYIFGETLAtaliGILVSKFGWVASNTVLYAAA 423
Cdd:TIGR00894 361 FYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLgfIKGITGLPGFIGGLIASTLA----GNILSQDSKNVWLIVFLIMA 436
|
410 420
....*....|....*....|....
gi 2532542707 424 FIALFLLIYILIREKKDIQEEVKE 447
Cdd:TIGR00894 437 FVNILCVIFYLIFGSAERQDWAKE 460
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
32-435 |
5.06e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.93 E-value: 5.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 32 LLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIF 111
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 112 LGSTQNFyvmmFLMLVISIAQGMGAAACQRTVQLWWG----KKRRGAIYSIWSSAHNAGAFACVaIVQFATFLFTDSIRD 187
Cdd:cd17328 81 SSFAPNF----WQLLLFRALVGIGEASYSPIAPTIIAdlfpKEKRTRALGVFYFAIPLGSGLGY-VVGGLVAQATGGWRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 188 VFYTASAVAIIIGIFILLVGSDRPTTVGlpsiteytgdviqlDTGEENNKEVSSLSLPqifMKYILNNKMVWAITLTSMF 267
Cdd:cd17328 156 AFRVTGVLGVLLAILLLLFVREPPRGAA--------------EGGVMAKSTATSFLAD---LKALAKNPSFILSTLGFTA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 268 LYLVRYGIMSWIPSYL-----VQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNY----RAIVCIGCVVGLI--AC 336
Cdd:cd17328 219 VSFVTGALAFWAPTFFlrafgVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKtpraDPLVCAVGLLAAApfLF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 337 LTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIFGETLATALIGiLVSKFGWVASN 416
Cdd:cd17328 299 LALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIG-LISDLLRQNKD 377
|
410 420
....*....|....*....|.
gi 2532542707 417 TVLYAAAFI--ALFLLIYILI 435
Cdd:cd17328 378 SPLAEAASLqyALLLCSFVLV 398
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
63-437 |
6.44e-08 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 54.63 E-value: 6.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 63 STAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLG-----STQNFYVMMFLMLVISIAQGMGAA 137
Cdd:cd17344 60 GTELLGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGlgyywNIHSLWYFVVVQILAGLFQSTGWP 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 138 ACQRTVQLWWGKKRRGAIYSIWSSaHNA-----GAFACVAIVQFA---TFlftdsirdvfytasavaIIIGIFILLVGsd 209
Cdd:cd17344 140 SVVACVGNWFGKGKRGLIMGIWNS-HTSvgnilGSLIAGIFVSSAwglSF-----------------IVPGIIIAAMG-- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 210 rpttvglpsiteytgdVIqldtgeennkevsslslpqIFMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKG-F 288
Cdd:cd17344 200 ----------------VL-------------------VFLFLVEHPPGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAiL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 289 SPDFAKWLVGIFELSAVPGVILIGAISDLLKNyRAIVCIGCVVGLIACLTAY-FFSQNHVLIVVILLIM-GSLIYAPLTL 366
Cdd:cd17344 245 SAKKAGDLSTLFDVGGIVGGILAGYISDYTGG-RATTCAAMLILAAPMLFIYnYFGQVSMTTNIVLLIVcGLLVNGPYAL 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2532542707 367 VGLMVNE--AVPKFAVGSSTGFMGFFQYIFGETLATALIGIL----VSKFGWVASNTVLYAAAFIALFLLIYILIRE 437
Cdd:cd17344 324 ITTAVSAdlGTHKSLKGNARALATVTAIIDGTGSIGAALGPLlaglISSRGWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
56-403 |
7.63e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 54.28 E-value: 7.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMG 135
Cdd:TIGR00895 43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRTVQLWWGKKRRGAIYSIWSSAHN-----AGAFACVAIVQFATflftdsiRDVFYTASAVAIIIGIFILLV---- 206
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPigaavGGFLAGWLIPVFGW-------RSLFYVGGIAPLLLLLLLMRFlpes 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 207 ----GSDRPTTVG------LPSITEYTGDVIQLDTGEENNKEVSSLSLPQifMKYILNNKMVWAITLTSMFLYlvrYGIM 276
Cdd:TIGR00895 196 idflVSKRPETVRrivnaiAPQMQAEAQSALPEQKSTQGTKRSVFKALFQ--GKTARITVLLWLLYFMLLVGV---YFLT 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 277 SWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKnyRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLIM 356
Cdd:TIGR00895 271 NWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG--PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIA 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2532542707 357 GSLIYAPLTLVGLMVNEAVPKFAVGSSTGFM---GFFQYIFGETLATALI 403
Cdd:TIGR00895 349 GFFVNGGQSGLYALMALFYPTAIRATGVGWAigiGRLGAIIGPILAGYLL 398
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
67-367 |
1.19e-07 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 53.47 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 67 IGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQ------NFYVMMFLMLVISIAQGMGAAACQ 140
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 141 RTVQLWWGKKRRGAIYSIWSSAHNA----GAFACVAIVQFA---TFLFTdsirdvfytaSAVAIIIGIFILLVGSDRPtt 213
Cdd:cd17342 145 AIMGNWFGKSSRGFVLGLWSACASVgniiGALLASSVLDYGyeyAFLVT----------SSLLFAGAIVVFFGLLSSP-- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 214 vglPSITEYtgdviqldtgeennkevsslslpqifmkyilnnkmvwaiTLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDF 292
Cdd:cd17342 213 ---PGVIPY---------------------------------------SLAYACLKLVNYSFFFWLPFYLSNNfHWKESE 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2532542707 293 AKWLVGIFELSAVPGVILIGAISDLLKNyRAIVCIGCVVGLIACLTAYFFSQNHVLI-VVILLIMGSLIYAPLTLV 367
Cdd:cd17342 251 ADQLSIWYDVGGIIGGIVAGYISDRMGS-RSPVVVVMLLLAIPSLFVYSHSPSDKVLnAFVMTITGFFIGGPANLI 325
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
261-439 |
2.11e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.42 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 261 ITLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCigCVVGLIACLTA 339
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI--GLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 340 YFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFqYIFGETLATALIGILVSKFGWVAsntVL 419
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAG-FGLGAALGPLLGGLLASLFGWRA---AF 154
|
170 180
....*....|....*....|
gi 2532542707 420 YAAAFIALFLLIYILIREKK 439
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPP 174
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
60-431 |
2.13e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.60 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 60 YHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAAC 139
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 140 QRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFTDSI--RDVFytasAVAIIIGIFILLVgsdrpttvglp 217
Cdd:cd17316 111 STYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwRILF----LIGALPALLALLL----------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 218 siteytgdviqldtgeennkevsslslpqifmkyilnNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWL 296
Cdd:cd17316 176 -------------------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 297 VGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVP 376
Cdd:cd17316 219 LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2532542707 377 KFAVGSSTGFMGFFQYIFGETLATALIGILVSKFGWVASNTVLYAAAFIALFLLI 431
Cdd:cd17316 299 TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
61-205 |
3.19e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 3.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 61 HFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQ 140
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2532542707 141 RTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFYTASAVAIIIGIFILL 205
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL--GLSAVFLLAGALLLLAALLLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
256-434 |
3.24e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.90 E-value: 3.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 256 KMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIvcIGCVVGLIA 335
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL--LLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 336 CLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVSKFGWVAS 415
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGL-GPALGPLLGGLLADLFGWRWV 166
|
170
....*....|....*....
gi 2532542707 416 NTVLYAAAFIALFLLIYIL 434
Cdd:COG2814 167 FLVNAVLALLALLLLLRLL 185
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
30-358 |
1.43e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 50.30 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 30 GVLLAICIGYI-GYYIIRliftteqTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVL 108
Cdd:cd17353 9 AVLMHLILGYQyAWSVFN-------PPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 109 NIFLG-STQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWgKKRRGAIYSIWSSAHNAGAFACVAIvqFATFLFTDSIRD 187
Cdd:cd17353 82 FILSAfAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPL--IAYLINTVGVPT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 188 VFYTASAVAIIIGIFILLVGSDRPTTVGLPSITEYTGDVIQLDTGEENNKEVSSLSLPQIFMKYILNNkmVWAITLTSMF 267
Cdd:cd17353 159 TFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNA--TAGLMLIGQA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 268 LYLVRygimswipsylVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIACLTAYFFSQNHV 347
Cdd:cd17353 237 KPIGQ-----------EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLS-IAFLIQGVAMFLLPFIGSVAV 304
|
330
....*....|.
gi 2532542707 348 LIVVILLIMGS 358
Cdd:cd17353 305 LFVLGVALIGF 315
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
55-436 |
1.52e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.89 E-value: 1.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 55 PIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGM 134
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 GAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAfacvAIVQFATFLFTDSI--RDVFYTASAVAIIIgiFILLVGSdrpt 212
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGA----ALGGFLAAALIPAFgwRSVFLLGGVPPLIL--LPLLRGT---- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 213 tvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYlvrYGIMSWIPSYLVQKGFSPDF 292
Cdd:cd17365 174 -------------------------------------------LLLWVTFFMGLLLV---YLLNSWLPKLMVEAGYSLSQ 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 293 AKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAyFFSQNHVLIVVILLIMGSLIYAPLTLvglmVN 372
Cdd:cd17365 208 ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLG-VSPASLVLLYVLVFLAGACVNGAQVG----LY 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 373 EAVPKF--------AVGSSTGfMGFFQYIFGETLATALIGilvskFGWVASN--TVLYAAAFIALFLLIYILIR 436
Cdd:cd17365 283 ALAARFyptevratGVGWALG-VGRLGAILGPLLGGLLLA-----AGLGPESvfLALAIPAALGALAVLLLRLR 350
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
1-207 |
2.29e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 2.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 1 MFSFLKPAPDSKKKVPANKIKST---YIW-RQTGVLLAICIGYIGYYIIrliftteqtPIMKAYH------FSTAQIGLI 70
Cdd:cd17473 168 LVLLFLPEPARKSKSAASPGAATaaaLPWkRVLPIYFLAFLAMLLFYVI---------PIQLPFLlqerggGSAALIGLA 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 71 LSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKK 150
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPE 318
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2532542707 151 RRGAIYSIWSSAHNAGAFACVAIVQFATFLFTDsIRDVFYTASAVAIIIGIFILLVG 207
Cdd:cd17473 319 LRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGG-LSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
55-433 |
4.38e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.69 E-value: 4.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 55 PIMKAYHFSTAQIGLIlscFGIGYGIS---KLFMGALSDKSNpnHY---LAAGLFISAVLNIFLGSTQNFYVMMFLMLVI 128
Cdd:cd17370 24 LFLVVLGASAAAVGLI---EGLAEALGsllRLFSGYLSDRTG--KRkplVILGYGLSALAKPLLALAGSWQLVLLLRILE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 129 SIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFILLVGS 208
Cdd:cd17370 99 RLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 209 DRPTTVGLpsiteytgdviqldtgEENNKEVSSLSLPQIFMKYILNNkMVWAITLTSMFLYLVRYGimswipsylvQKGF 288
Cdd:cd17370 179 EYPRPPKL----------------RKKSKKTSLKKLPKAFWLYLLAV-ALFALGNFSFAFLILRAQ----------ELGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 289 SPDFAKWLVGIFELSAVPGVILIGAISDlLKNYRAIVCIGCVVGLIACLT-AYFFSQNHVLIVVIL--LIMGSLIYAPLT 365
Cdd:cd17370 232 SAALIPLLYALFNLVYALAAYPAGRLSD-RIGRKKLLILGYLSLALAYLGfALGSSLWLLLLGFILwgLYMGAQESIERA 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 366 LVGLMVNEAVPKFAVGSSTGFMGFFQYIfgetlATALIGILVSKFGWVAsnTVLYAAAFIALFLLIYI 433
Cdd:cd17370 311 AVADLVPAELRGTAYGLFNTVVGIGWLL-----ASLIAGYLWDLISPSA--AFLFSAVLALIALLLLL 371
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
249-374 |
7.47e-06 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 48.03 E-value: 7.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 249 MKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFEL-SAVPGVILIGAISDlLKNYRAIVCI 327
Cdd:cd17409 190 GGSVWRSPLAWQVTLFLGLNSFIYYVLVGWLPSILTDAGYSAAQAGSLHGLLQLaTAVPGLLLIPVLAR-MKDQRLLAVL 268
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2532542707 328 GCVVGLIACLTAYFFSQnHVLIVVILLIMGS---LIYApLTLVGLMVNEA 374
Cdd:cd17409 269 VSLLGAVGLIGLLLAPS-LAILWVILFGFGSgagFILG-LAFIGLRTSSA 316
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
56-408 |
1.03e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.55 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVisiaQGMG 135
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARAL----QGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAACQRT----VQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIRDVFYtasaVAIIIGIFILLVGsdrp 211
Cdd:cd17321 98 AAAIMPAslalIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF--GWRWIFL----INVPIGLVALLLA---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 212 ttvglpsiteytgdviqldtgeennkevsslslpqifmkyilnnKMVWAITLTSMFLYLVRYGIMSWIPSYL-VQKGFSP 290
Cdd:cd17321 168 --------------------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLqGVLGYSP 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 291 DFAKWLVGIFELSAVPGVILIGAISDLLkNYRAIVCIGCVVGLIACLTAYFFSQNH--VLIVVILLIMG---SLIYAPLT 365
Cdd:cd17321 204 LQAGLALLPLALAMLVAAPLAGRLADRF-GPRLVLVAGLLLTAVGLLLLALLGADSsvWLLLPGLVLLGlglGLFATPLT 282
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2532542707 366 LVGLmvnEAVPKFAVGSSTGFMGFFQYIfGETLATALIGILVS 408
Cdd:cd17321 283 NAAL---SSVPKEKAGAASGILNTARQL-GGALGVALLGALLT 321
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-436 |
1.03e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 31 VLLAICIGYIGYYIirliFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17489 1 ILLANFFFFLSFYL----LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRG---AIYSIWSSAHNA-GAFACVAIVQFATFLFtdsir 186
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGegiGYYGLATTLAMAlGPALGLFLYQHLGFAV----- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 187 dVFYTASAVAIIIGIFILLVgsdrpttvglpsiteytgdviqldtgEENNKEVSSLSLPQIFMKYILNNKMVWAITLTSM 266
Cdd:cd17489 152 -LFIVAAVLALLALLLVFLV--------------------------KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 267 FLYLVRYGIMSWIPSYLVQKGFSpdfAKWLV-GIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTAYFFSQN 345
Cdd:cd17489 205 LASIAYGAISTFLPLYAAERGIS---NAGLFfTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPW 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 346 HVLIVVILLIMGSLIYAPlTLVGLMVNEAVP-KFAVGSSTGFMGFfqyIFGETLATALIGILVSKFGWvaSNTVLYAAAF 424
Cdd:cd17489 282 MLLLAAVLYGLGFGLLFP-ALQALAVDLVPPhRRGAANGTFFIFF---DLGIGLGGLLLGLVAELFGY--RAMFLLAAVV 355
|
410
....*....|..
gi 2532542707 425 IALFLLIYILIR 436
Cdd:cd17489 356 VLLALVLYIFLL 367
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
43-434 |
1.54e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.78 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 43 YIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIF--LGSTQNFYV 120
Cdd:cd17380 12 YADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 121 MMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFatFLFTDSIRDVFYTASAVAIIIG 200
Cdd:cd17380 92 LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPL--LLEYYGWPSVFYFFGLLGLLWA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 201 IFILLVgsdrpttvgLPSiteytgdviqldtgeennkevsslslpqifmkyilnnkmVWAITLTSMFLYLVRYGIMSWIP 280
Cdd:cd17380 170 LVWLIY---------LPP---------------------------------------VWAIIVAHFCMNWGFYILLSWLP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 281 SYLvQKGFSPDFAKWLVGIFE-LSAVPGVILIGAISDLL--KNYRAIV---CIGCVVGLIACLTAYFFSQNHVLIVVILL 354
Cdd:cd17380 202 TYF-HEVLVPLAKGWVFNVVPwLVMFPSSNVAGWLADHLisRGWTVTSvrkLMQSIGFLGPALFLLLLSHTDSFSLALLC 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 355 IMGSLIYAPLTLVGLMVNEA--VPKFAvGSSTGFMGFFQYIFGeTLATALIGILVSKFGWVASntVLYAAAFIALF-LLI 431
Cdd:cd17380 281 MSVALGLSAFSSSGVLVNHQdiAPNYA-GIVFGISNTAGTIPG-IVGVYLTGYILEATGSWSL--VFVLAAVVNLVgAVV 356
|
...
gi 2532542707 432 YIL 434
Cdd:cd17380 357 FLL 359
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
4-206 |
5.07e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.25 E-value: 5.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 4 FLKPAPDSKKKVPANKIKSTYIWRQTG-----VLLAICIGYIGYYiirLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGY 78
Cdd:cd17474 171 FLLPEPKEKAKSSSATKLRDLKKALRGrglltFLVSAFLYFFLYF---AFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 79 GISKLFMGALSDKSNPNHY-LAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYS 157
Cdd:cd17474 248 ALGSLFVGRLLKKRFGARRiLVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2532542707 158 IWSSAHNAGafACVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFILLV 206
Cdd:cd17474 328 LYNFVRFLG--QAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
27-219 |
8.45e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.42 E-value: 8.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 27 RQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISA 106
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 107 VLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFLFtdSIR 186
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL--GWR 168
|
170 180 190
....*....|....*....|....*....|...
gi 2532542707 187 DVFYTASAVAIIIGIFILLVGSDRPTTVGLPSI 219
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGLLLALLAL 201
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
257-430 |
1.05e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 44.09 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 257 MVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIA 335
Cdd:cd17502 168 TILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVG 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 336 CLTAYFFSQN-HVLIVVILLIMGSLIYAPLTLVGLM-VNEAVPKFAVGSSTGFMGFFQyifgeTLATAlIGILVSKFGWV 413
Cdd:cd17502 248 AGLLTTLTLDtSKWLLIGYLILLGLGLGIGFQQPLVaVQNAVPPADVGVATATNTFFR-----SLGGT-LGVAITDVFLV 321
|
170
....*....|....*..
gi 2532542707 414 AsnTVLYAAAFIALFLL 430
Cdd:cd17502 322 A--LALAALAFLLSLFL 336
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-206 |
1.45e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.71 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 32 LLAICIGYIGYYIIRLIFTTEQTPIMK-AYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPN---HYLAAGLFISAV 107
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYLKqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGarrLVIIIGLLLAAV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 LNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIVQFATFlFTDSIRD 187
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVD-ATGSYTA 339
|
170
....*....|....*....
gi 2532542707 188 VFYTASAVAIIIGIFILLV 206
Cdd:cd17319 340 AFLFLAAVALLAALLVLLL 358
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
31-138 |
1.47e-04 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 43.77 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 31 VLLAICIGYIGYYIIRLIFTTEqtpimKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNI 110
Cdd:cd17336 9 CLLGLLQGAVVSYFVSTITTIE-----KRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCF 83
|
90 100
....*....|....*....|....*...
gi 2532542707 111 FLGSTQNFYVMMFLMlvisiaqGMGAAA 138
Cdd:cd17336 84 LLALPHFLFVGQFLL-------GIGSSP 104
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
6-204 |
1.80e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.57 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 6 KPAPDSKKKVPANKIKSTYIWRQTGVLLAICIGYIGYYIIRLIFTTEQTPIMKAY-HFSTAQIGLILSCFGIGYGISKLF 84
Cdd:cd06174 179 SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLgGLSVAVAGLLLSLFGLAGALGSLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 85 MGALSDKSNPNHYL-AAGLFISAVLNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAh 163
Cdd:cd06174 259 LGLLSDRLIGRKPLlLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTF- 337
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2532542707 164 NAGAFACVAIVQFATFLFTDSIRDVFYTASAVAIIIGIFIL 204
Cdd:cd06174 338 GFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
56-434 |
2.16e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.34 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMmflmLVISIAQGMG 135
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVL----IAGRALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAA---CQRTVQLWWGKKRRGAIYSIWSSAHNAGA----FACVAIVQFATFlftdsiRDVFYTASAVAIIIGIFILLVgs 208
Cdd:cd17504 98 GAVfplAFALVREEFPPERVPVAQGILSATFGIGAgiglPLGGWIVQHLGW------RWIFWTAAPVAVLLAALVPLI-- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 209 drpttvglpsiteytgdviqldtgeennkevsSLSLpqifmkyiLNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KG 287
Cdd:cd17504 170 --------------------------------DLRL--------LRRRNVLLANITALLAGFGMFMVFQLLPQLLQLpTP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 288 FSPDFAKWLVGIFELSAVPGVILIGAISDLLKN---YRAIVCIGCVVGLIACLTAYFFSQNHVLIVVILLIMG---SLIY 361
Cdd:cd17504 210 TGFGLGITEAGLLLLPGALVMLIAGPLAGRLIArvgPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGiglGLAF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 362 APLTlvgLMVNEAVPKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKF-GWVASNTVLYAAAFIALFLLIYIL 434
Cdd:cd17504 290 ASLP---NIVVESVPPDRTGIATGMNTVLRTIGS-AIGPAIAGAILTTYtVSITSGGVPTEGAYVLAFLIGAAL 359
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
61-131 |
3.35e-04 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 42.62 E-value: 3.35e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2532542707 61 HFSTAQIGLILSCFGIGYGISKLFMGALSDKS-NPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVISIA 131
Cdd:cd06177 29 GFTGAQIGAVYSTTGIAAIIMPFFLGIIADRFfAAEKVLAVLHLIGAAALFYAATVTDFSVFFWVMLLYSLC 100
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
63-436 |
3.68e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.60 E-value: 3.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 63 STAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFL-----GSTQNFYVMMFLMLVISIAQGMGAA 137
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLallalLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 138 ACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIvqfATFLFT-DSIRDVFYTASAVAIIIGIFILLVGSDRPTTVGL 216
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPAL---GGLLVAlLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 217 PSITEYTGDViqldtgeennkevsslslpqIFMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQK-GFSPDFAKW 295
Cdd:cd06173 189 SSSLLLRDLR--------------------EGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 296 LVGIFELSAVPGVILIGAISDLLKNYRAIvcIGCVVGLIACLTAYFFSQNHVLIVVILLIMGSLIYAPLTLVGLMVNEAV 375
Cdd:cd06173 249 LLAAFGVGALLGALLLGRLSKRRRRGRLL--LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2532542707 376 PKFAVGSSTGFMGFFQYIFGeTLATALIGILVSKFGWVAsntVLYAAAFIALFLLIYILIR 436
Cdd:cd06173 327 PDELRGRVFSVYNALNSGAM-PLGALLAGLLADALGLSA---VFLLAGALLLLAALLLLLL 383
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
252-395 |
7.59e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.38 E-value: 7.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 252 ILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVV 331
Cdd:cd17352 179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLL 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2532542707 332 GLIACLTAYFFSQNHVLIVVILLIMGSLI--YAPLTLVGLMVNEAVPKF--AVGSSTGFMGFFQYIFG 395
Cdd:cd17352 259 ILGLSLLAFPLATTYVGLIVFSVLFGFCSgsYSSLTPVILADLVGLEKLsnAYGLVLLFQGLAALVGP 326
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
252-435 |
7.80e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.41 E-value: 7.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 252 ILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLVQ-KGFSPDFAKWLVGIFELSAVPGVILIGAISDLLkNYRAIVCIGCV 330
Cdd:cd17503 174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF-GPRLLLLAGLL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 331 VGLIACLTAYFFS--QNHVLIVVILLIMG---SLIYAPLTLVGLMvneAVPKFAVGSSTGFMGFFQyIFGETLATALIGI 405
Cdd:cd17503 253 LLALGTLLLAFLTpdTSLWLIILPLFIRGlgmGLVFMPLNTLALN---SLPPEQIGDATALFNTIR-QLGGSIGTALLAT 328
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2532542707 406 LVSKFGWVASNTVL-----------YAAAFIALFLLIYILI 435
Cdd:cd17503 329 LLTNRTQFHHSRLSellaqqvqkqaLIIAFNDAFLVSAILL 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
29-206 |
1.08e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 29 TGVLLAICIGYIGYYIIRLIFtteqtpIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAV- 107
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLY------LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVg 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 108 --LNIFLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFACVAIV----------- 174
Cdd:cd17321 248 llLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLgalltaglsan 327
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2532542707 175 ----------QFATFLFTDSIRDVFYTASAVAIIIGIFILLV 206
Cdd:cd17321 328 lgdsgvaallSAAAAAFAAGFHLAFLVAAALALLAALLALLL 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
6-169 |
1.27e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 6 KPAPDSKKKVPANKIKSTYIWRQTGVLLAIcIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFM 85
Cdd:pfam07690 177 SKRPKPAEEARLSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 86 GALSDKSNPNHYLAAGLFISAVLNI---FLGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSA 162
Cdd:pfam07690 256 GRLSDRLGRRRRLLLALLLLILAALgllLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTA 335
|
....*..
gi 2532542707 163 HNAGAFA 169
Cdd:pfam07690 336 GSLGGAL 342
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
302-431 |
1.59e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.52 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 302 LSAVPGVILIGAISDLLKNYRAIVcIGCVVGLIACLTAYFFSQNHVLIVVILLI---MGSLIYAPLTLVGLMVNEavpkf 378
Cdd:COG2270 285 IVAALGALLFGRLDDRIGPKRVIL-VSLVIWIVVCLAAYFLTTALAFWILGLLIglvMGGIQALSRSLLARLIPP----- 358
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2532542707 379 avGSSTGFMGFFQyIFGEtlATALIGILVskFGWV--ASNTVLYAAAFIALFLLI 431
Cdd:COG2270 359 --GREAEFFGLYA-LSGK--AASFLGPLL--FGLVtqLTGSQRLGILSLIVFFVI 406
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
57-139 |
1.88e-03 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 40.40 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 57 MKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFL--GSTQNFYVMMFLMLVISIAQGM 134
Cdd:cd17382 41 KAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIpiAARVHYGCVIFVRILQGLVEGV 120
|
....*
gi 2532542707 135 GAAAC 139
Cdd:cd17382 121 TYPAC 125
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
31-434 |
2.37e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 40.08 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 31 VLLAICIGYIGYYIIRLIFTTEQTPIMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNpnhyLAAGLFISAVLNI 110
Cdd:cd17334 5 VLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVG----LRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 111 F--------LGSTQNFYVMMFLMLVISIAQGMGAAACQRTVQLWWGKKRRGAIYSIWSSAHNAG---AFACVAIVQFATF 179
Cdd:cd17334 81 LgsvlkcipLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGcaiGFLLPPVVVPPPK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 180 LFTDSIRDVFYTASAVAIIIGIFILLVGSDRPTTVglPSITeytgdviqldTGEENNKEVSSLSLpQIFMKYILNNKMVW 259
Cdd:cd17334 161 GTKKEFGAVFYGEFGFACLLLALVLALFPPKPKYP--PSAA----------SARQQNSEHVILEL-QKSISELLRNEPFV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 260 AITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGCVVGLIACLTA 339
Cdd:cd17334 228 LLAVAFSIMMGVFAGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFF 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 340 YFFSQNHVLIVVILlimgsLIYAPLTLVGLMVNEAVP---KFAV--------GSSTGFMGFFQYIFGeTLATALIGILVS 408
Cdd:cd17334 308 MLLVDRYGLPYVTL-----AFYLLCGLLGFFQNSMVPimfELAVeltypvpeSVSTGVLTALANLFS-FLLMLVFSELLG 381
|
410 420
....*....|....*....|....*.
gi 2532542707 409 KFGWVASNTVLYAAAFIALFLLIYIL 434
Cdd:cd17334 382 PTPTESKYLLWFILCTVGSCLGALFF 407
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
258-447 |
2.46e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 2.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 258 VWAITLTSMFLYLVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIGcvVGLIACL 337
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILG--YGLSALA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 338 TAYFFSQNHVLIVVILLIMGSL---IYAPLTLVglMVNEAVPKFAVGSSTGFMGFFQyIFGETLAtALIGILVSKFGWVA 414
Cdd:cd17370 79 KPLLALAGSWQLVLLLRILERLgkgIRTPPRDA--LLADATPPSGRGKAFGLHRALD-TLGAVLG-PLLAALLLYLLGGN 154
|
170 180 190
....*....|....*....|....*....|....
gi 2532542707 415 SNTVLYAAAFIALF-LLIYILIREKKDIQEEVKE 447
Cdd:cd17370 155 YRTIFLLAAIPALLaLLILLFVVKEYPRPPKLRK 188
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
270-339 |
2.90e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 39.95 E-value: 2.90e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 270 LVRYGIMSWIPSYLVQKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYRAIVCIgcVVGLIACLTA 339
Cdd:PRK11551 234 IVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLI--YAGILASLAA 301
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
56-356 |
3.28e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.54 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGS-TQNFYVMMFLMLVISIAqGM 134
Cdd:cd17341 25 IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALaVSSYWGLLVLGFLLGFA-GA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 135 GAAACQRTVQLWWGKKRRGAIYSIWSSAHNAGafacVAIVQFATFLFTDSI---------RDVFYTASAVAIIIGIFILL 205
Cdd:cd17341 104 NFASGQPWASFWFPKEKIGGAAGGIAGAGNMG----VAVSQLLAPLIAGAIvfdggfvgwRNAFFVPGILLAIAAVLVLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 206 VGSDRPTTvglpsiteytgdviqldtgeennKEVSSLSLPQifMKYILNNKMVWAITLTSMFLYLVRYGIMSWIPSYLV- 284
Cdd:cd17341 180 FGDDLPTG-----------------------KASALEFLKV--QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKt 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2532542707 285 QKGFSPDFAKWLVGIFELSAVPGVILIGAISDLLKNYR--AIVCIGCVVGLIACltAYFFSQNHVLIVVILLIM 356
Cdd:cd17341 235 RFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRrlWWLFIVMTIGAALL--SLSLPTSGTNLVLFLALF 306
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
56-433 |
7.28e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 38.33 E-value: 7.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 56 IMKAYHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIFLGSTQNFYVMMFLMLVisiaQGMG 135
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFL----QGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 136 AAAC----QRTVQLWWGKKRRGAIYSIwssahnAGAFACVAIV------QFATFLFtdSIRDVFYTASAVAIIIGIFILL 205
Cdd:cd17320 101 AAAGsvvaRAIVRDLYSGAELAKIFSL------LMMILAIAPAlapllgGLLLLFF--GWRAIFVFLALLGLLLLLLVLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 206 VgsdrpttvgLPSiteytgdviqldTGEENNKEVSSLSLPQIFmKYILNNKMVWAITLTSMFLYLvryGIMSWIPS---- 281
Cdd:cd17320 173 F---------LPE------------TLPEEKRKPLLSSLLRAY-KRVLKNRRFLGYALALGLSFA---GLFAYLAAapfi 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 282 YLVQKGFSPDfakwLVGIFELSAVPGVILIGAISD-LLKNYRAIVCIGCVVGLIACLTAyffsqnhVLIVVILLIMGSLI 360
Cdd:cd17320 228 YIEQLGLSPA----QFGLLFALNAIALILGSLLNGrLVRRFGPRRLLRLGLLLLLAAAL-------VLLLAALLGGLSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 361 Y--APLTLVGLMVNEAVP----------KFAVGSSTGFMGFFQYIFGeTLATALIGILVSkFGWVASNTVLYAAAFIALF 428
Cdd:cd17320 297 PlvAPLFLIFFGFGLIFPnatslalepfPHVAGTASALLGFLQFLIG-ALAGALVGLLPN-GTALPMGLLILVLGLLALL 374
|
....*
gi 2532542707 429 LLIYI 433
Cdd:cd17320 375 LLILL 379
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
60-435 |
8.92e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.37 E-value: 8.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 60 YHFSTAQIGLILSCFGIGYGISKLFMGALSDKSNPNHYLAAGLFISAVLNIF--LGSTQNFYVMMFLMLVISIAQGMGAA 137
Cdd:cd17318 51 FDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLtpLAARGGYGALIVLRILQGLAQGVTFP 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 138 ACQRTVQLWWGKKRRGAIYSIWSSAHNAGAFacvaIVQFATFLFTDSIR--DVFYTASAVAIIIGIFILLvgsdrpttvg 215
Cdd:cd17318 131 AMHALWAKWAPPLERSRLTSIAYSGSQFGTV----IAMPLSGFLCESLGwpSIFYIFGGLGLLWCLLWFF---------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 216 lpsiteytgdviqldtgeennkevssLSLPqifmkyilnnkmVWAITLTSMFLYLVRYGIMSWIPSYLvQKGFSPDFAKw 295
Cdd:cd17318 197 --------------------------LVLP------------VWAIVVAHFGHNWGFYTLLTELPTYM-SDVLHFNIKS- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 296 lVGIfeLSAVPGV------ILIGAISDLLKNY--------RAIVCIGCVVGLIACLTAY-FFSQNHVLIVVILLImgSLI 360
Cdd:cd17318 237 -NGF--LSSLPYLamwicsIVGGYLADWLRSRgilstttvRKLFTSIGFLGPGVFLIALgYLGSNATLAVVFLTL--SVG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532542707 361 YAPLTLVGLMVN--EAVPKFAvGSSTGFMGFFQYIFGeTLATALIGILVSK----FGWvasNTVLYAAAFIALFLLIYIL 434
Cdd:cd17318 312 LSGACYSGFLVNhlDLAPNYA-GTLMGITNTAATIAG-IISPLIVGAIVKNdqtiGQW---RIVFFISAAIYILGAIFYL 386
|
.
gi 2532542707 435 I 435
Cdd:cd17318 387 I 387
|
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