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Conserved domains on  [gi|2532790175|ref|WP_290209897|]
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MULTISPECIES: efflux RND transporter periplasmic adaptor subunit [unclassified Pseudoalteromonas]

Protein Classification

efflux RND transporter periplasmic adaptor subunit( domain architecture ID 11436533)

efflux RND (resistance-nodulation-division) transporter periplasmic adaptor subunit, similar to Bacillus subtilis YknX, which is part of an unusual four-component transporter with a role in protection against sporulation-delaying-protein-induced killing

CATH:  2.40.50.100|2.40.420.20|2.40.30.170|1.10.287.470
Gene Ontology:  GO:0016020|GO:0055085|GO:0022857|GO:0042802
PubMed:  32073314
TCDB:  2.A.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 49-373 7.90e-50

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


:

Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 170.51  E-value: 7.90e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  49 VAANNHQVVINSYGEVKPLESTRLSAQVSGEVVSWHpnFVAGGIVARGETLFTIEKDNYEAALlqaqaelaqaqaqlieE 128
Cdd:COG0845     3 VERGDVPETVEATGTVEARREVEVRARVSGRVEEVL--VDEGDRVKKGQVLARLDPPDLQAAL----------------A 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 129 QAQAQVAEDEA------------KRFPDKE---RTALFLRKPQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVVS 193
Cdd:COG0845    65 QAQAQLAAAQAqlelakaeleryKALLKKGavsQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGE 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 194 REIGVGQYINMGTQVAELNNIETAEVIIPIAGFDSVFLPervKGIKATVMKTGLHGFSREAKIDRDLGVVDNATRMSSLV 273
Cdd:COG0845   145 RNVEPGQLVSAGTPLFTIADLDPLEVEFDVPESDLARLK---VGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVR 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 274 VRIDdpyglvNKQHAIKYGTYVQVNFAGAMLENIYRLPQELV----NNQTVWIVNAEQQLEPRKVKVIREEGEYFYISDG 349
Cdd:COG0845   222 AELP------NPDGLLRPGMFVRVRIVLGERENALLVPASAVvrdgGGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSG 295

                         330       340
                  ....*....|....*....|....
gi 2532790175 350 LEADDQLVMTLPEYPQKGMAVKVA 373
Cdd:COG0845   296 LKAGDRVVVSGLQRLRDGAKVRVV 319
 
Name Accession Description Interval E-value
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 49-373 7.90e-50

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 170.51  E-value: 7.90e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  49 VAANNHQVVINSYGEVKPLESTRLSAQVSGEVVSWHpnFVAGGIVARGETLFTIEKDNYEAALlqaqaelaqaqaqlieE 128
Cdd:COG0845     3 VERGDVPETVEATGTVEARREVEVRARVSGRVEEVL--VDEGDRVKKGQVLARLDPPDLQAAL----------------A 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 129 QAQAQVAEDEA------------KRFPDKE---RTALFLRKPQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVVS 193
Cdd:COG0845    65 QAQAQLAAAQAqlelakaeleryKALLKKGavsQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGE 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 194 REIGVGQYINMGTQVAELNNIETAEVIIPIAGFDSVFLPervKGIKATVMKTGLHGFSREAKIDRDLGVVDNATRMSSLV 273
Cdd:COG0845   145 RNVEPGQLVSAGTPLFTIADLDPLEVEFDVPESDLARLK---VGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVR 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 274 VRIDdpyglvNKQHAIKYGTYVQVNFAGAMLENIYRLPQELV----NNQTVWIVNAEQQLEPRKVKVIREEGEYFYISDG 349
Cdd:COG0845   222 AELP------NPDGLLRPGMFVRVRIVLGERENALLVPASAVvrdgGGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSG 295

                         330       340
                  ....*....|....*....|....
gi 2532790175 350 LEADDQLVMTLPEYPQKGMAVKVA 373
Cdd:COG0845   296 LKAGDRVVVSGLQRLRDGAKVRVV 319
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 44-372 2.90e-26

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 107.40  E-value: 2.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  44 VKVEPVAANNHQVVINSYGEVKPLESTRLSAQVSGEVVSWhpNFVAGGIVARGETLFTIEKDNYEAALLQAQAELAQAqa 123
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKI--SVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAA-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 124 qlieeQAQAQVAEDEAKRFpdkerTALFLR-----------KPQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVV 192
Cdd:TIGR01730  77 -----EAQLELAQRSFERA-----ERLVKRnavsqadlddaKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 193 SREIGVGQYINMGTQVAELNNIETAEViipiagfdSVFLPER-----VKGIKATVMKTGLHGFSREAKIDRDLGVVDNAT 267
Cdd:TIGR01730 147 RRLVEVGAYVTAGQTLATIVDLDPLEA--------DFSVPERdlpqlRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGT 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 268 RMSSLVVRIDDPYGlvnkqhAIKYGTYVQVNFAGAMLENIYRLPQELV----NNQTVWIVNAEQQLEPRKVKVIREEGEY 343
Cdd:TIGR01730 219 GTVRVRATFPNPDG------RLLPGMFGRVTISLKVRSSAIVVPTQAViedlNGKYVYVVKNDGKVSKRPVEVGLRNGGY 292

                         330       340
                  ....*....|....*....|....*....
gi 2532790175 344 FYISDGLEADDQLVMTLPEYPQKGMAVKV 372
Cdd:TIGR01730 293 VEIESGLKAGDQIVTAGVVKLRDGAKVKV 321
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
62-357 4.48e-09

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 57.88  E-value: 4.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  62 GEVKPLESTRLSAQVSGEVVSWHpnFVAGGIVARGETLFTIEKDNYEAALLqaqaelaqaqaqlieeQAQAQVAEDEA-- 139
Cdd:PRK11556   80 GTVTAANTVTVRSRVDGQLMALH--FQEGQQVKAGDLLAEIDPRPFKVALA----------------QAQGQLAKDQAtl 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 140 -------KRFPDKERTALFLRK------PQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVVSREIGVGQYINMGT 206
Cdd:PRK11556  142 anarrdlARYQQLAKTNLVSRQeldaqqALVSETEGTIKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGD 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 207 QvaelnnieTAEVII----PIagfDSVF-LPErvkGIKATVM---KTGlHGFSREAkIDRdlgvvDNATRMS-----SLV 273
Cdd:PRK11556  222 T--------TGIVVItqthPI---DLVFtLPE---SDIATVVqaqKAG-KPLVVEA-WDR-----TNSKKLSegtllSLD 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 274 VRIDDPYGLV-------NKQHAIKYGTYVQVNFAGAMLENIYRLPQELV----NNQTVWIVNAEQQLEPRKVKVIREEGE 342
Cdd:PRK11556  281 NQIDATTGTIklkarfnNQDDALFPNQFVNARMLVDTLQNAVVIPTAALqmgnEGHFVWVLNDENKVSKHLVTPGIQDSQ 360

                         330
                  ....*....|....*
gi 2532790175 343 YFYISDGLEADDQLV 357
Cdd:PRK11556  361 KVVISAGLSAGDRVV 375
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
 182-284 1.25e-08

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 52.36  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 182 EVTAPYDALVVSREIGVGQYINMGTQVAELNNIETAEVIIPIAGFDSVFLPervKGIKATVMKTGLHGFSREAKIDRDLG 261
Cdd:pfam13437   1 TIRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLK---KGQKVTLKLDPGSDYTLEGKVVRISP 77

                          90       100
                  ....*....|....*....|...
gi 2532790175 262 VVDNATRMSSLVVRIDDPYGLVN 284
Cdd:pfam13437  78 TVDPDTGVIPVRVSIENPKTPIP 100
 
Name Accession Description Interval E-value
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 49-373 7.90e-50

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 170.51  E-value: 7.90e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  49 VAANNHQVVINSYGEVKPLESTRLSAQVSGEVVSWHpnFVAGGIVARGETLFTIEKDNYEAALlqaqaelaqaqaqlieE 128
Cdd:COG0845     3 VERGDVPETVEATGTVEARREVEVRARVSGRVEEVL--VDEGDRVKKGQVLARLDPPDLQAAL----------------A 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 129 QAQAQVAEDEA------------KRFPDKE---RTALFLRKPQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVVS 193
Cdd:COG0845    65 QAQAQLAAAQAqlelakaeleryKALLKKGavsQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGE 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 194 REIGVGQYINMGTQVAELNNIETAEVIIPIAGFDSVFLPervKGIKATVMKTGLHGFSREAKIDRDLGVVDNATRMSSLV 273
Cdd:COG0845   145 RNVEPGQLVSAGTPLFTIADLDPLEVEFDVPESDLARLK---VGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVR 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 274 VRIDdpyglvNKQHAIKYGTYVQVNFAGAMLENIYRLPQELV----NNQTVWIVNAEQQLEPRKVKVIREEGEYFYISDG 349
Cdd:COG0845   222 AELP------NPDGLLRPGMFVRVRIVLGERENALLVPASAVvrdgGGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSG 295

                         330       340
                  ....*....|....*....|....
gi 2532790175 350 LEADDQLVMTLPEYPQKGMAVKVA 373
Cdd:COG0845   296 LKAGDRVVVSGLQRLRDGAKVRVV 319
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 44-372 2.90e-26

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 107.40  E-value: 2.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  44 VKVEPVAANNHQVVINSYGEVKPLESTRLSAQVSGEVVSWhpNFVAGGIVARGETLFTIEKDNYEAALLQAQAELAQAqa 123
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKI--SVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAA-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 124 qlieeQAQAQVAEDEAKRFpdkerTALFLR-----------KPQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVV 192
Cdd:TIGR01730  77 -----EAQLELAQRSFERA-----ERLVKRnavsqadlddaKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 193 SREIGVGQYINMGTQVAELNNIETAEViipiagfdSVFLPER-----VKGIKATVMKTGLHGFSREAKIDRDLGVVDNAT 267
Cdd:TIGR01730 147 RRLVEVGAYVTAGQTLATIVDLDPLEA--------DFSVPERdlpqlRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGT 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 268 RMSSLVVRIDDPYGlvnkqhAIKYGTYVQVNFAGAMLENIYRLPQELV----NNQTVWIVNAEQQLEPRKVKVIREEGEY 343
Cdd:TIGR01730 219 GTVRVRATFPNPDG------RLLPGMFGRVTISLKVRSSAIVVPTQAViedlNGKYVYVVKNDGKVSKRPVEVGLRNGGY 292

                         330       340
                  ....*....|....*....|....*....
gi 2532790175 344 FYISDGLEADDQLVMTLPEYPQKGMAVKV 372
Cdd:TIGR01730 293 VEIESGLKAGDQIVTAGVVKLRDGAKVKV 321
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
128-299 6.29e-10

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 60.06  E-value: 6.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 128 EQAQAQVAEDEAKRfpdKERTALFLRKPQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVVSREIGVGQYINMGTQ 207
Cdd:COG1566   158 DAAQAQLEAAQAQL---AQAQAGLREEEELAAAQAQVAQAEAALAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQP 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 208 VAELNNIETAEVIIPIAGFDSVFLperVKGIKATVMKTGLHGFSREAKIDR------DLGVVDNATRMSSLV----VRID 277
Cdd:COG1566   235 LLTIVPLDDLWVEAYVPETDLGRV---KPGQPVEVRVDAYPDRVFEGKVTSispgagFTSPPKNATGNVVQRypvrIRLD 311

                         170       180
                  ....*....|....*....|..
gi 2532790175 278 DPYGlvnkqHAIKYGTYVQVNF 299
Cdd:COG1566   312 NPDP-----EPLRPGMSATVEI 328
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
62-357 4.48e-09

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 57.88  E-value: 4.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  62 GEVKPLESTRLSAQVSGEVVSWHpnFVAGGIVARGETLFTIEKDNYEAALLqaqaelaqaqaqlieeQAQAQVAEDEA-- 139
Cdd:PRK11556   80 GTVTAANTVTVRSRVDGQLMALH--FQEGQQVKAGDLLAEIDPRPFKVALA----------------QAQGQLAKDQAtl 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 140 -------KRFPDKERTALFLRK------PQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVVSREIGVGQYINMGT 206
Cdd:PRK11556  142 anarrdlARYQQLAKTNLVSRQeldaqqALVSETEGTIKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGD 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 207 QvaelnnieTAEVII----PIagfDSVF-LPErvkGIKATVM---KTGlHGFSREAkIDRdlgvvDNATRMS-----SLV 273
Cdd:PRK11556  222 T--------TGIVVItqthPI---DLVFtLPE---SDIATVVqaqKAG-KPLVVEA-WDR-----TNSKKLSegtllSLD 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 274 VRIDDPYGLV-------NKQHAIKYGTYVQVNFAGAMLENIYRLPQELV----NNQTVWIVNAEQQLEPRKVKVIREEGE 342
Cdd:PRK11556  281 NQIDATTGTIklkarfnNQDDALFPNQFVNARMLVDTLQNAVVIPTAALqmgnEGHFVWVLNDENKVSKHLVTPGIQDSQ 360

                         330
                  ....*....|....*
gi 2532790175 343 YFYISDGLEADDQLV 357
Cdd:PRK11556  361 KVVISAGLSAGDRVV 375
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
 182-284 1.25e-08

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 52.36  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 182 EVTAPYDALVVSREIGVGQYINMGTQVAELNNIETAEVIIPIAGFDSVFLPervKGIKATVMKTGLHGFSREAKIDRDLG 261
Cdd:pfam13437   1 TIRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLK---KGQKVTLKLDPGSDYTLEGKVVRISP 77

                          90       100
                  ....*....|....*....|...
gi 2532790175 262 VVDNATRMSSLVVRIDDPYGLVN 284
Cdd:pfam13437  78 TVDPDTGVIPVRVSIENPKTPIP 100
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
44-391 3.87e-08

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 54.72  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  44 VKVEPVaannhQVVINSYGEVKPLESTRLSAQVSGEVVSwhPNFVAGGIVARGETLFTIEKDNYEAALLQAQAELAqaqa 123
Cdd:PRK15030   45 VKTEPL-----QITTELPGRTSAYRIAEVRPQVSGIILK--RNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLA---- 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 124 qliEEQAQAQVAEDEAKRFPDKERTALFLRKP--QVLS----AKASVKSAQARLKRAQRDLDNCEVTAPYDALVVSREIG 197
Cdd:PRK15030  114 ---KAQAAANIAQLTVNRYQKLLGTQYISKQEydQALAdaqqANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVT 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 198 VGQYINMG--TQVAELNNIETAEVIIPIAGFDSVFLPERVKG---------IKATVMKTGLHGFSREAKIDRDLGVVDNA 266
Cdd:PRK15030  191 EGALVQNGqaTALATVQQLDPIYVDVTQSSNDFLRLKQELANgtlkqengkAKVSLITSDGIKFPQDGTLEFSDVTVDQT 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 267 TrmSSLVVRIDDPyglvNKQHAIKYGTYVQVNFAGAMLENIYRLPQELVN-----NQTVWIVNAEQQLEPRKVKVIREEG 341
Cdd:PRK15030  271 T--GSITLRAIFP----NPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTrtprgDATVLVVGADDKVETRPIVASQAIG 344

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2532790175 342 EYFYISDGLEADDQLVMTLPEYPQKGMAVKVAGVQDVKKIDALDSAATEK 391
Cdd:PRK15030  345 DKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQ 394
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 53-358 4.66e-07

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 51.27  E-value: 4.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  53 NHQVVINSYGEVKPL-ESTRLSAQVSGEVVswHPNFVAGGIVARGETLFTIEKDNYEAALLQAQAELAqaqaqliEEQAQ 131
Cdd:pfam00529   3 PLTKGVEAPGRVVVSgNAKAVQPQVSGIVT--RVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLA-------KAQAQ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 132 AQVAEDEAKRFPDKERTALFLRKP------QVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDAlvVSREigvgQYINMG 205
Cdd:pfam00529  74 VARLQAELDRLQALESELAISRQDydgataQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGG--ISRE----SLVTAG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 206 TQVAELNNIETA----------EVIIPIAGFDSVFLPERVKG------IKATVMKTGLHGFSREAKIDRDlGVVDNAT-R 268
Cdd:pfam00529 148 ALVAQAQANLLAtvaqldqiyvQITQSAAENQAEVRSELSGAqlqiaeAEAELKLAKLDLERTEIRAPVD-GTVAFLSvT 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 269 MSSLVVRIDDPYGLVNKQHaikyGTYVQVNFAGAMLENIY-----RLPQELVNNQ-----TVWIVNAEQQLEPRKVKVIR 338
Cdd:pfam00529 227 VDGGTVSAGLRLMFVVPED----NLLVPGMFVETQLDQVRvgqpvLIPFDAFPQTktgrfTGVVVGISPDTGPVRVVVDK 302

                         330       340
                  ....*....|....*....|
gi 2532790175 339 EEGEYFYISDGLEADDQLVM 358
Cdd:pfam00529 303 AQGPYYPLRIGLSAGALVRL 322
HlyD_D23 pfam16576
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ...
 169-295 4.96e-04

Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.


Pssm-ID: 435440 [Multi-domain]  Cd Length: 214  Bit Score: 40.95  E-value: 4.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 169 ARLKRAQRDLDNCEVTAPYDALVVSREIGVGQYINMGTQVAELNNIET----AEViipiagfdsvflPER----VK-GIK 239
Cdd:pfam16576  97 AELERTGKVQPTVTVYAPISGVVTELNVREGMYVQPGDTLFTIADLSTvwveADV------------PEQdlalVKvGQP 164

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2532790175 240 ATVMKTGLHGFSREAKIDRDLGVVDNATRmsSLVVRIDdpygLVNKQHAIKYGTYV 295
Cdd:pfam16576 165 AEVTLPALPGKTFEGKVDYIYPTLDPKTR--TVRVRIE----LPNPDGRLKPGMFA 214
PRK09578 PRK09578
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
129-372 7.23e-04

MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 169982 [Multi-domain]  Cd Length: 385  Bit Score: 41.32  E-value: 7.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 129 QAQAQVAEDEAKRFPDKERT-ALFLRKPQV-----LSAKASVKSAQARLKRAQRDLDNCEVTAPYD-----ALVVSREIg 197
Cdd:PRK09578  114 EAAHLAALDKRRRYDDLVRDrAVSERDYTEavadeRQAKAAVASAKAELARAQLQLDYATVTAPIDgrarrALVTEGAL- 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 198 VGQyinmgTQVAELNNIETAEVII-----PIAGFDSV---FLPERVKGIK-----ATVMKTGLHGFSREAKI-DRDLGvV 263
Cdd:PRK09578  193 VGQ-----DQATPLTTVEQLDPIYvnfsqPAADVEALrraVKSGRATGIAqqdvaVTLVRADGSEYPLKGKLlFSDLA-V 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 264 DNATRMSSLVVRIDDPyglvnkQHAIKYGTYVQVNFAGAMLENIYRLPQELV----NNQTVWIVNAEQQLEPRKVKVIRE 339
Cdd:PRK09578  267 DPTTDTVAMRALFPNP------ERELLPGAYVRIALDRAVNPRAILVPRDALlrtaDSASVKVVGQNGKVRDVEVEADQM 340

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2532790175 340 EGEYFYISDGLEADDQLVMTLPEYPQKGMAVKV 372
Cdd:PRK09578  341 SGRDWIVTRGLAGGERVIVDNAAQFAPGTAVKA 373
PRK10476 PRK10476
multidrug transporter subunit MdtN;
159-202 9.03e-04

multidrug transporter subunit MdtN;


Pssm-ID: 182488 [Multi-domain]  Cd Length: 346  Bit Score: 41.17  E-value: 9.03e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2532790175 159 SAKASVKSAQARLKRAQRDLDNCEVTAPYDALVVSREIGVGQYI 202
Cdd:PRK10476  187 ALVAQRAAREAALAIAELHLEDTTVRAPFDGRVVGLKVSVGEFA 230
PRK03598 PRK03598
putative efflux pump membrane fusion protein; Provisional
 128-208 1.65e-03

putative efflux pump membrane fusion protein; Provisional


Pssm-ID: 235136 [Multi-domain]  Cd Length: 331  Bit Score: 39.95  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 128 EQAQAQVAEDEAKRFPDKERTALFL---RKPQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVVSREIGVGQYINM 204
Cdd:PRK03598  148 ENARSSRDQAQATLKSAQDKLSQYRegnRPQDIAQAKASLAQAQAALAQAELNLQDTELIAPSDGTILTRAVEPGTMLNA 227


                  ....
gi 2532790175 205 GTQV 208
Cdd:PRK03598  228 GSTV 231
PRK09859 PRK09859
multidrug transporter subunit MdtE;
42-359 4.70e-03

multidrug transporter subunit MdtE;


Pssm-ID: 137559 [Multi-domain]  Cd Length: 385  Bit Score: 38.93  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175  42 PVVKVEPVAANNHQVVINSYGEVKPLESTRLSAQVSGEVVSwhPNFVAGGIVARGETLFTIEKD------NYEAALLQAQ 115
Cdd:PRK09859   34 PEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIK--RNFIEGDKVNQGDSLYQIDPAplqaelNSAKGSLAKA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 116 AELAQAQAQLIEEQAQAQVAEDEAKRFPDKERTalflrkpQVLSAKASVKSAQARLKRAQRDLDNCEVTAPYDALVVSRE 195
Cdd:PRK09859  112 LSTASNARITFNRQASLLKTNYVSRQDYDTART-------QLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSS 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 196 IGVGQYI--NMGTQVAELNNIETAEVIIPIAGFDSVFLPE-----RVKGIK-ATVMKTGLHG---FSREAKIDRDLGVVD 264
Cdd:PRK09859  185 VTVGALVtaNQADSLVTVQRLDPIYVDLTQSVQDFLRMKEevasgQIKQVQgSTPVQLNLENgkrYSQTGTLKFSDPTVD 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532790175 265 NATRMSSLVVRIDDPYGlvnkqhAIKYGTYVQVNFAGAMLENIYRLPQELVNNQ-----TVWIVNAEQQLEPRKVKVIRE 339
Cdd:PRK09859  265 ETTGSVTLRAIFPNPNG------DLLPGMYVTALVDEGSRQNVLLVPQEGVTHNaqgkaTALILDKDDVVQLREIEASKA 338

                         330       340
                  ....*....|....*....|
gi 2532790175 340 EGEYFYISDGLEADDQLVMT 359
Cdd:PRK09859  339 IGDQWVVTSGLQAGDRVIVS 358
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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