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Conserved domains on  [gi|2534428689|ref|WP_291324941.1|]
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Sec-independent protein translocase protein TatB

Protein Classification

twin-arginine translocase TatA/TatE family subunit( domain architecture ID 10004603)

twin-arginine translocase TatA/TatE family subunit similar to Sec-independent protein translocase protein TatA, which may form the protein-conducting channel of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TatA COG1826
Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, ...
 1-72 9.54e-21

Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 441431 [Multi-domain]  Cd Length: 72  Bit Score: 79.98  E-value: 9.54e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2534428689   1 MIDIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEVNRSMELDELKKMKDTVENAARD 72
Cdd:COG1826     1 MFGIGFWELLIILVVALLVFGPKKLPELARSLGKAIREFKKAANEVKEELDEELKEEELRKSEKEAEELKKA 72
 
Name Accession Description Interval E-value
TatA COG1826
Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, ...
 1-72 9.54e-21

Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441431 [Multi-domain]  Cd Length: 72  Bit Score: 79.98  E-value: 9.54e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2534428689   1 MIDIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEVNRSMELDELKKMKDTVENAARD 72
Cdd:COG1826     1 MFGIGFWELLIILVVALLVFGPKKLPELARSLGKAIREFKKAANEVKEELDEELKEEELRKSEKEAEELKKA 72
PRK04654 PRK04654
sec-independent translocase; Provisional
 1-86 1.61e-16

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 72.92  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534428689   1 MIDIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEVNRSMELDELKKMKDTVENAARDVEQSIQTS 80
Cdd:PRK04654    1 MFDIGVGELTLIAVVALVVLGPERLPKAARFAGLWVRRARMQWDSVKQELERELEAEELKRSLQDVQASLREAEDQLRNT 80


                  ....*.
gi 2534428689  81 ASEFEK 86
Cdd:PRK04654   81 QQQVEQ 86
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 3-69 3.17e-15

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 66.18  E-value: 3.17e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2534428689   3 DIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEVNRSMELDELKKMKDTVENA 69
Cdd:TIGR01410   2 DIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQA 68
TatA_B_E pfam02416
mttA/Hcf106 family; Members of this protein family are involved in a sec independent ...
 4-49 4.84e-05

mttA/Hcf106 family; Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif.


Pssm-ID: 426762  Cd Length: 53  Bit Score: 38.83  E-value: 4.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2534428689   4 IGLSKMALIGVVALIVIGPEKLPRVARTVGALLG---KAQRYVADVKSE 49
Cdd:pfam02416   1 LGIPELLIILVVALLLFGPKKLPELGRALGKTLRefkKATKELEEEDEK 49
 
Name Accession Description Interval E-value
TatA COG1826
Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, ...
 1-72 9.54e-21

Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441431 [Multi-domain]  Cd Length: 72  Bit Score: 79.98  E-value: 9.54e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2534428689   1 MIDIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEVNRSMELDELKKMKDTVENAARD 72
Cdd:COG1826     1 MFGIGFWELLIILVVALLVFGPKKLPELARSLGKAIREFKKAANEVKEELDEELKEEELRKSEKEAEELKKA 72
PRK04654 PRK04654
sec-independent translocase; Provisional
 1-86 1.61e-16

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 72.92  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534428689   1 MIDIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEVNRSMELDELKKMKDTVENAARDVEQSIQTS 80
Cdd:PRK04654    1 MFDIGVGELTLIAVVALVVLGPERLPKAARFAGLWVRRARMQWDSVKQELERELEAEELKRSLQDVQASLREAEDQLRNT 80


                  ....*.
gi 2534428689  81 ASEFEK 86
Cdd:PRK04654   81 QQQVEQ 86
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 3-69 3.17e-15

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 66.18  E-value: 3.17e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2534428689   3 DIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEVNRSMELDELKKMKDTVENA 69
Cdd:TIGR01410   2 DIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQA 68
tatA PRK14857
TatA/E family twin arginine-targeting protein translocase;
4-83 6.63e-13

TatA/E family twin arginine-targeting protein translocase;


Pssm-ID: 184859  Cd Length: 90  Bit Score: 60.50  E-value: 6.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534428689   4 IGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEVNRSM-ELDELKKMKDTVE-NAARDVEQSIQTSA 81
Cdd:PRK14857    6 IGLPEMAVILVIALLVFGPKKLPEIGRSLGKTLKGFQEASKEFENEIKREMaEPEQEVKAPAELEsNQTNEANQEQVDAE 85


                  ..
gi 2534428689  82 SE 83
Cdd:PRK14857   86 NS 87
tatA PRK14858
twin arginine translocase protein A; Provisional
 1-95 2.94e-10

twin arginine translocase protein A; Provisional


Pssm-ID: 184860  Cd Length: 108  Bit Score: 54.10  E-value: 2.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534428689   1 MIDIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKsevnRSMELDE-LKKMKDTVENAARDVEQSIQT 79
Cdd:PRK14858    1 MFGIGMPELIVILVIALIVIGPQKLPDLARSLGRGLAEFKKATDDFK----QSMQEESrTAEEKEKAEKLAETKKEAEAP 76

                          90
                  ....*....|....*.
gi 2534428689  80 SASEFEKDLAQAAGTT 95
Cdd:PRK14858   77 EAKAEEDQAPKPKGAG 92
PRK01371 PRK01371
Sec-independent protein translocase protein TatB;
1-108 5.70e-08

Sec-independent protein translocase protein TatB;


Pssm-ID: 179287 [Multi-domain]  Cd Length: 137  Bit Score: 48.55  E-value: 5.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534428689   1 MIDIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYV----ADVKSEVN---RSMELDEL-------KKMKDTV 66
Cdd:PRK01371    1 MFGIGPGELVVLVVLAVLVFGPDKLPKAARDAGRTLRQLREMAnnarNDLRSELGpefADLDLRDLnpktfvrKHLLEDL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2534428689  67 ENAARDVEQSIQTSASEFEKDLAQAAGTTTGELQDPFAVVPA 108
Cdd:PRK01371   81 DDDIDEIKLGLKTVRSGLDLGDEDPAVPAAGNGRRPEASSSV 122
tatB PRK00182
Sec-independent protein translocase subunit TatB;
4-61 2.63e-06

Sec-independent protein translocase subunit TatB;


Pssm-ID: 234681  Cd Length: 160  Bit Score: 44.82  E-value: 2.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534428689   4 IGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEVNRSM--ELDELKK 61
Cdd:PRK00182    5 VGWGEILLLLIVGLIVIGPERLPRLIEDVRAALLAARTAINNAKQQLDGDFgeEFDEFRK 64
tatA PRK14861
twin arginine translocase protein A; Provisional
 1-65 7.96e-06

twin arginine translocase protein A; Provisional


Pssm-ID: 237837  Cd Length: 61  Bit Score: 41.11  E-value: 7.96e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2534428689   1 MIDIGLSKMALIGVVALIVIGPEKLPRVARTVGALLGKAQRYVADVKSEvnrsmELDELKKMKDT 65
Cdd:PRK14861    2 FSNIGFPGLILILVVALIIFGPKKLPELGKALGKTLREFKKATKELTDD-----DFQEKKKKEKM 61
tatA PRK14860
twin arginine translocase protein A; Provisional
 1-33 3.33e-05

twin arginine translocase protein A; Provisional


Pssm-ID: 184862  Cd Length: 64  Bit Score: 39.72  E-value: 3.33e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2534428689   1 MIDIGLSKMALIGVVALIVIGPEKLPRVARTVG 33
Cdd:PRK14860    1 MFGFGMPELIVILVIALVVFGPAKLPQLGQALG 33
TatA_B_E pfam02416
mttA/Hcf106 family; Members of this protein family are involved in a sec independent ...
 4-49 4.84e-05

mttA/Hcf106 family; Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif.


Pssm-ID: 426762  Cd Length: 53  Bit Score: 38.83  E-value: 4.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2534428689   4 IGLSKMALIGVVALIVIGPEKLPRVARTVGALLG---KAQRYVADVKSE 49
Cdd:pfam02416   1 LGIPELLIILVVALLLFGPKKLPELGRALGKTLRefkKATKELEEEDEK 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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