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Conserved domains on  [gi|2538713928|ref|WP_295005771|]
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methyl-accepting chemotaxis protein [Sulfurimonas sp.]

Protein Classification

methyl-accepting chemotaxis domain-containing protein( domain architecture ID 1562453)

methyl-accepting chemotaxis protein (MCP) domain-containing protein similar to bacterial receptors that mediate chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

Gene Ontology:  GO:0007165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCP_signal super family cl46910
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 293-372 5.35e-32

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


The actual alignment was detected with superfamily member cd11386:

Pssm-ID: 481250 [Multi-domain]  Cd Length: 200  Bit Score: 119.26  E-value: 5.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538713928 293 DNLVDLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQktlnDAKVEISGVVDSI 372
Cdd:cd11386    54 SAVEELEESSAEIGEIVEVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESA----EAAKEIEELIEEI 129
 
Name Accession Description Interval E-value
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 293-372 5.35e-32

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 119.26  E-value: 5.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538713928 293 DNLVDLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQktlnDAKVEISGVVDSI 372
Cdd:cd11386    54 SAVEELEESSAEIGEIVEVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESA----EAAKEIEELIEEI 129
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
282-374 2.92e-30

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 121.28  E-value: 2.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538713928 282 EDEEQESSMFNDNLVDLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKtlndA 361
Cdd:COG0840   340 EEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAE----A 415

                          90
                  ....*....|...
gi 2538713928 362 KVEISGVVDSISS 374
Cdd:COG0840   416 TKEIEELIEEIQS 428
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 292-372 3.88e-30

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 116.23  E-value: 3.88e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538713928  292 NDNLVDLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKTLNdakvEISGVVDS 371
Cdd:smart00283  80 VSAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAK----EIESLIKE 155


                   .
gi 2538713928  372 I 372
Cdd:smart00283 156 I 156
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 297-372 1.96e-27

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 106.36  E-value: 1.96e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2538713928 297 DLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQktlnDAKVEISGVVDSI 372
Cdd:pfam00015  27 QIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSA----QAAKEIEALIIEI 98
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 297-373 9.83e-17

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 81.59  E-value: 9.83e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2538713928 297 DLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKTLNDAKVEISgvvDSIS 373
Cdd:PRK15048  351 EIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIE---DSVS 424
 
Name Accession Description Interval E-value
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 293-372 5.35e-32

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 119.26  E-value: 5.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538713928 293 DNLVDLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQktlnDAKVEISGVVDSI 372
Cdd:cd11386    54 SAVEELEESSAEIGEIVEVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESA----EAAKEIEELIEEI 129
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
282-374 2.92e-30

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 121.28  E-value: 2.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538713928 282 EDEEQESSMFNDNLVDLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKtlndA 361
Cdd:COG0840   340 EEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAE----A 415

                          90
                  ....*....|...
gi 2538713928 362 KVEISGVVDSISS 374
Cdd:COG0840   416 TKEIEELIEEIQS 428
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 292-372 3.88e-30

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 116.23  E-value: 3.88e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538713928  292 NDNLVDLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKTLNdakvEISGVVDS 371
Cdd:smart00283  80 VSAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAK----EIESLIKE 155


                   .
gi 2538713928  372 I 372
Cdd:smart00283 156 I 156
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 297-372 1.96e-27

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 106.36  E-value: 1.96e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2538713928 297 DLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQktlnDAKVEISGVVDSI 372
Cdd:pfam00015  27 QIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSA----QAAKEIEALIIEI 98
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 297-373 9.83e-17

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 81.59  E-value: 9.83e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2538713928 297 DLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKTLNDAKVEISgvvDSIS 373
Cdd:PRK15048  351 EIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIE---DSVS 424
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
293-373 2.40e-16

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 80.38  E-value: 2.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538713928 293 DNLV----DLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKtlndAKVEISGV 368
Cdd:PRK15041  345 DNVVqtmrDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQ----AAREIKSL 420


                  ....*.
gi 2538713928 369 V-DSIS 373
Cdd:PRK15041  421 IeDSVG 426
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
278-372 2.66e-16

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 80.12  E-value: 2.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2538713928 278 HNYKEDEEQESSMfNDNLVDLQNQSKDIFTVLETISDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKT 357
Cdd:PRK09793  331 TTAQAGGVQVSTM-THTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQA 409

                          90
                  ....*....|....*
gi 2538713928 358 LNDAKVEISGVVDSI 372
Cdd:PRK09793  410 AKEIKGLIEESVNRV 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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