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Conserved domains on  [gi|2539099344|ref|WP_295360380|]
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STAS domain-containing protein [uncultured Succiniclasticum sp.]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 321-405 1.34e-11

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


:

Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 60.61  E-value: 1.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 321 MHYTMENGLFRVSLCGRLDSITAPELLLKWEkEKTATNIERAIVDCERLTYISSAGVRVLLTMEEKTK---CGVTLIHVS 397
Cdd:cd07043     1 ITVEERGGVLVVRLSGELDAATAPELREALE-ELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARaagGRLVLVNVS 79


                  ....*...
gi 2539099344 398 PLVKKLLE 405
Cdd:cd07043    80 PAVRRVLE 87
Cellulase-like super family cl46800
Sugar-binding cellulase-like; This is a putative cellulase family. The structure is a ...
 79-290 5.37e-09

Sugar-binding cellulase-like; This is a putative cellulase family. The structure is a TIM-barrel.


The actual alignment was detected with superfamily member COG3315:

Pssm-ID: 481140  Cd Length: 246  Bit Score: 56.51  E-value: 5.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344  79 NSGYRTCVDLPCGYTPKAFHLT-AKGIQFIGLDLPIVVQEMEPVMHSLTAyPERMAFHPVDATNYD---SLDAALEKTAG 154
Cdd:COG3315    54 AAGIAQVVILGAGLDTRAYRLDnPGGVRWFEVDLPEVIALKRRLLPELGP-PARLRLVAVDLRDPDwpdALPAAGFDPSR 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 155 PLCITTEGMMMYFTESELEAVVNNVCTLLEVHGGAWFTpdpefmiqffltfqslFGEDWMKKLEAAGNAAKKQSDVANLS 234
Cdd:COG3315   133 PTLFIAEGVLMYLTEEAVRALLRRIAALFPPGSELAFD----------------YVPPLALKGSKKHPAVRKLRRDLGAP 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2539099344 235 NSFIIDAADIpgsvkrtEAFLAKFGLKA-EKLNLAEYMPELSTYRFLTSEQIVQFKK 290
Cdd:COG3315   197 FKFGIDPDDP-------AELLEEPGWRLvEELSPLELLARYLPLRPLRAPRLVHARF 246
 
Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 321-405 1.34e-11

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 60.61  E-value: 1.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 321 MHYTMENGLFRVSLCGRLDSITAPELLLKWEkEKTATNIERAIVDCERLTYISSAGVRVLLTMEEKTK---CGVTLIHVS 397
Cdd:cd07043     1 ITVEERGGVLVVRLSGELDAATAPELREALE-ELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARaagGRLVLVNVS 79


                  ....*...
gi 2539099344 398 PLVKKLLE 405
Cdd:cd07043    80 PAVRRVLE 87
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 324-405 1.72e-10

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 57.17  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 324 TMENGLFRVSLCGRLDSITAPELLLKWEkEKTATNIERAIVDCERLTYISSAGVRVLLTMEEKTK---CGVTLIHVSPLV 400
Cdd:COG1366     5 EVRDGVLVLPLIGELDAARAPELREALL-EALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARllgGRLVLVGVSPAV 83


                  ....*
gi 2539099344 401 KKLLE 405
Cdd:COG1366    84 ARVLE 88
YktD COG3315
O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, ...
 79-290 5.37e-09

O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442544  Cd Length: 246  Bit Score: 56.51  E-value: 5.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344  79 NSGYRTCVDLPCGYTPKAFHLT-AKGIQFIGLDLPIVVQEMEPVMHSLTAyPERMAFHPVDATNYD---SLDAALEKTAG 154
Cdd:COG3315    54 AAGIAQVVILGAGLDTRAYRLDnPGGVRWFEVDLPEVIALKRRLLPELGP-PARLRLVAVDLRDPDwpdALPAAGFDPSR 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 155 PLCITTEGMMMYFTESELEAVVNNVCTLLEVHGGAWFTpdpefmiqffltfqslFGEDWMKKLEAAGNAAKKQSDVANLS 234
Cdd:COG3315   133 PTLFIAEGVLMYLTEEAVRALLRRIAALFPPGSELAFD----------------YVPPLALKGSKKHPAVRKLRRDLGAP 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2539099344 235 NSFIIDAADIpgsvkrtEAFLAKFGLKA-EKLNLAEYMPELSTYRFLTSEQIVQFKK 290
Cdd:COG3315   197 FKFGIDPDDP-------AELLEEPGWRLvEELSPLELLARYLPLRPLRAPRLVHARF 246
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 320-406 7.78e-07

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 47.21  E-value: 7.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 320 AMHYTME--NGLFRVSLCGRLDSITAPELLLKWEKEKTATNIERAIVDCERLTYISSAGVRVLL-TMEEKTKCGVTLI-- 394
Cdd:TIGR00377   2 NLNIETEvqEGVVVVRLSGELDAHTAPLLREKVTPAAERTGIRPIVLDLEDLEFMDSSGLGVLLgRYKQVRRVGGQLVlv 81

                          90
                  ....*....|..
gi 2539099344 395 HVSPLVKKLLEQ 406
Cdd:TIGR00377  82 SVSPRVARLLDI 93
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 332-406 2.07e-06

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 45.29  E-value: 2.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2539099344 332 VSLCGRLDSITAPELLLKWEKEKTATniERAIVDCERLTYISSAGVRVLLTME---EKTKCGVTLIHVSPLVKKLLEQ 406
Cdd:pfam13466   1 LSLSGELDADTAPALREALLAALAAG--SPVVVDLSGVERVDSAGLALLLALArraRARGKRLVLRGLPPALLRLLRL 76
 
Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 321-405 1.34e-11

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 60.61  E-value: 1.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 321 MHYTMENGLFRVSLCGRLDSITAPELLLKWEkEKTATNIERAIVDCERLTYISSAGVRVLLTMEEKTK---CGVTLIHVS 397
Cdd:cd07043     1 ITVEERGGVLVVRLSGELDAATAPELREALE-ELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARaagGRLVLVNVS 79


                  ....*...
gi 2539099344 398 PLVKKLLE 405
Cdd:cd07043    80 PAVRRVLE 87
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 324-405 1.72e-10

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 57.17  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 324 TMENGLFRVSLCGRLDSITAPELLLKWEkEKTATNIERAIVDCERLTYISSAGVRVLLTMEEKTK---CGVTLIHVSPLV 400
Cdd:COG1366     5 EVRDGVLVLPLIGELDAARAPELREALL-EALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARllgGRLVLVGVSPAV 83


                  ....*
gi 2539099344 401 KKLLE 405
Cdd:COG1366    84 ARVLE 88
YktD COG3315
O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, ...
 79-290 5.37e-09

O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442544  Cd Length: 246  Bit Score: 56.51  E-value: 5.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344  79 NSGYRTCVDLPCGYTPKAFHLT-AKGIQFIGLDLPIVVQEMEPVMHSLTAyPERMAFHPVDATNYD---SLDAALEKTAG 154
Cdd:COG3315    54 AAGIAQVVILGAGLDTRAYRLDnPGGVRWFEVDLPEVIALKRRLLPELGP-PARLRLVAVDLRDPDwpdALPAAGFDPSR 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 155 PLCITTEGMMMYFTESELEAVVNNVCTLLEVHGGAWFTpdpefmiqffltfqslFGEDWMKKLEAAGNAAKKQSDVANLS 234
Cdd:COG3315   133 PTLFIAEGVLMYLTEEAVRALLRRIAALFPPGSELAFD----------------YVPPLALKGSKKHPAVRKLRRDLGAP 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2539099344 235 NSFIIDAADIpgsvkrtEAFLAKFGLKA-EKLNLAEYMPELSTYRFLTSEQIVQFKK 290
Cdd:COG3315   197 FKFGIDPDDP-------AELLEEPGWRLvEELSPLELLARYLPLRPLRAPRLVHARF 246
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 320-406 7.78e-07

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 47.21  E-value: 7.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 320 AMHYTME--NGLFRVSLCGRLDSITAPELLLKWEKEKTATNIERAIVDCERLTYISSAGVRVLL-TMEEKTKCGVTLI-- 394
Cdd:TIGR00377   2 NLNIETEvqEGVVVVRLSGELDAHTAPLLREKVTPAAERTGIRPIVLDLEDLEFMDSSGLGVLLgRYKQVRRVGGQLVlv 81

                          90
                  ....*....|..
gi 2539099344 395 HVSPLVKKLLEQ 406
Cdd:TIGR00377  82 SVSPRVARLLDI 93
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 332-406 2.07e-06

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 45.29  E-value: 2.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2539099344 332 VSLCGRLDSITAPELLLKWEKEKTATniERAIVDCERLTYISSAGVRVLLTME---EKTKCGVTLIHVSPLVKKLLEQ 406
Cdd:pfam13466   1 LSLSGELDADTAPALREALLAALAAG--SPVVVDLSGVERVDSAGLALLLALArraRARGKRLVLRGLPPALLRLLRL 76
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 329-406 1.31e-05

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 43.76  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 329 LFRVSlcGRLDSITAPEL---LLKWEKEKTATNIeraIVDCERLTYISSAGVRVLLTMEEKTKC-GVTLIHV--SPLVKK 402
Cdd:pfam01740  12 ILRLD--GPLDFANAESLrerLLRALEEGEIKHV---VLDLSAVPFIDSSGLGALEELYKELRRrGVELVLVgpSPEVAR 86


                  ....
gi 2539099344 403 LLEQ 406
Cdd:pfam01740  87 TLEK 90
MlaB COG3113
Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, ...
 331-405 9.37e-04

Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442347 [Multi-domain]  Cd Length: 97  Bit Score: 38.31  E-value: 9.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2539099344 331 RVSLCGRLDSITAPELllkWEK-EKTATNIERAIVDCERLTYISSAGVRVLLTME---EKTKCGVTLIHVSPLVKKLLE 405
Cdd:COG3113    13 TLRLSGELTRDTVLAL---WAQlLALLAAGGAVEIDLSGVTRVDSAGLALLLELLreaRAQGKTLRLTGVPEQLRTLAA 88
STAS cd06844
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of ...
 332-408 2.17e-03

Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain is found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors, like anti-anti-sigma factors and "stressosome" components. The sigma factor regulators are involved in protein-protein interaction which is regulated by phosphorylation.


Pssm-ID: 132911 [Multi-domain]  Cd Length: 100  Bit Score: 37.46  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539099344 332 VSLCGRLDSITAPELllkweKEKTATNIERAIV-----DCERLTYISSAGVRVLL-TMEEKTKCG--VTLIHVSPLVKKL 403
Cdd:cd06844    12 VRLEGELDHHSVEQF-----KEELLHNITNVAGktiviDISALEFMDSSGTGVLLeRSRLAEAVGgqFVLTGISPAVRIT 86


                  ....*
gi 2539099344 404 LEQNE 408
Cdd:cd06844    87 LTESG 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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