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Conserved domains on  [gi|2554591105|ref|WP_303647819|]
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HAMP domain-containing sensor histidine kinase [Haloarchaeobius amylolyticus]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
26-320 9.27e-47

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 160.84  E-value: 9.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  26 FLIGAAIFTVGVRVVRRGYRPARVRRLTGWTVAGGVAGGLSLLVFSSIHTLDFGGQLVSAHLLLDGLTAGILGAGGGLVL 105
Cdd:COG0642    10 LLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 106 GLYADRLTERTRELEAANERLDEFASMVSHDLRNPLTVATLSLKLARETGEEKRFDAVDRAH---ERMGVLVDELLVLAR 182
Cdd:COG0642    90 LLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILrsaDRLLRLINDLLDLSR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 183 --QGTDITDPVPTDVEVVAREAWDTVATE----GATLVVGLE---RTVLADAERLRTLFENLYRNSIEHGRRDATVTI-- 251
Cdd:COG0642   170 leAGKLELEPEPVDLAELLEEVVELFRPLaeekGIELELDLPddlPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVsv 249

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2554591105 252 --GETATGFFVEDDGPGIDVARRGEIFAGGYTT----TEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEFE 320
Cdd:COG0642   250 rrEGDRVRISVEDTGPGIPPEDLERIFEPFFRTdpsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVT 324
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
26-320 9.27e-47

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 160.84  E-value: 9.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  26 FLIGAAIFTVGVRVVRRGYRPARVRRLTGWTVAGGVAGGLSLLVFSSIHTLDFGGQLVSAHLLLDGLTAGILGAGGGLVL 105
Cdd:COG0642    10 LLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 106 GLYADRLTERTRELEAANERLDEFASMVSHDLRNPLTVATLSLKLARETGEEKRFDAVDRAH---ERMGVLVDELLVLAR 182
Cdd:COG0642    90 LLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILrsaDRLLRLINDLLDLSR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 183 --QGTDITDPVPTDVEVVAREAWDTVATE----GATLVVGLE---RTVLADAERLRTLFENLYRNSIEHGRRDATVTI-- 251
Cdd:COG0642   170 leAGKLELEPEPVDLAELLEEVVELFRPLaeekGIELELDLPddlPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVsv 249

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2554591105 252 --GETATGFFVEDDGPGIDVARRGEIFAGGYTT----TEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEFE 320
Cdd:COG0642   250 rrEGDRVRISVEDTGPGIPPEDLERIFEPFFRTdpsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVT 324
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 223-323 8.86e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 85.78  E-value: 8.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  223 ADAERLRTLFENLYRNSIEHGRRDATVTIGETATG----FFVEDDGPGIDVARRGEIFAGGYTTTE-----HGTGLGLSI 293
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGdhveITVEDNGPGIPPEDLEKIFEPFFRTDKrsrkiGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 2554591105  294 VRRIARAHGWRVRVTDGSTGGARFEFEVRP 323
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
62-327 2.50e-19

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 88.49  E-value: 2.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  62 AGGLSLLVFSSIhTLDFGGQLVSAHLLLDGLTAGilgaggglvlglyaDRLTERTRELE--AAnerLDEFASMVSHDLRN 139
Cdd:PRK11360  342 DRTIELSVSTSL-LHNTHGEMIGALVIFSDLTER--------------KRLQRRVARQErlAA---LGELVAGVAHEIRN 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 140 PLTVATLSLKLARE----TGEEKRFDAVDRAHERMGVLVDELLVLARQGTDITDPVPTD--VEVVAREAWDTVATEGATL 213
Cdd:PRK11360  404 PLTAIRGYVQIWRQqtsdPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNalVEEVLQLFQTAGVQARVDF 483

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 214 VVGLER---TVLADAERLRTLFENLYRNSIEHGRRDATVTI-----GETATGFFVEDDGPGIDVARRGEIFAGGYTTTEH 285
Cdd:PRK11360  484 ETELDNelpPIWADPELLKQVLLNILINAVQAISARGKIRIrtwqySDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK 563

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2554591105 286 GTGLGLSIVRRIARAHGWRVRVTDGSTGGA--RFEFEVRPGDGL 327
Cdd:PRK11360  564 GTGLGLALSQRIINAHGGDIEVESEPGVGTtfTLYLPINPQGNQ 607
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 223-322 4.34e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.56  E-value: 4.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 223 ADAERLRTLFENLYRNSIEHGRRDATVTI---GETATGFFVEDDGPGIDVARRGEIFAGGYTTTEH---GTGLGLSIVRR 296
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVtlsEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....*.
gi 2554591105 297 IARAHGWRVRVTDGSTGGARFEFEVR 322
Cdd:pfam02518  81 LVELLGGTITVESEPGGGTTVTLTLP 106
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 119-321 1.16e-15

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 77.43  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 119 LEAANERLDEFASMVSHDLRNPLT--VATLSLKLARE-TGEEKRfDAVDRA---HERMGVLVDELLVLAR--QGTDITDP 190
Cdd:TIGR01386 234 LEDAFQRLSQFSADLAHELRTPLTnlLGQTQVALSQPrTGEEYR-EVLESNleeLERLSRMVSDMLFLARadNGQLALER 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 191 VPTDVEVVAR---EAWDTVATE-GATLVVGLERTVLADAERLRTLFENLYRNSIEHGRRDATVTIG-ETATGFF---VED 262
Cdd:TIGR01386 313 VRLDLAAELAkvaEYFEPLAEErGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRiERRSDEVrvsVSN 392

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2554591105 263 DGPGIDVARRGEIF------AGGYTTTEHGTGLGLSIVRRIARAHGWRVRVT--DGSTggaRFEFEV 321
Cdd:TIGR01386 393 PGPGIPPEHLSRLFdrfyrvDPARSNSGEGTGLGLAIVRSIMEAHGGRASAEspDGKT---RFILRF 456
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-319 4.42e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 70.12  E-value: 4.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 234 NLYRNSIE---HG---RRDATVTIGETATGF---FVEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIVRRIARAHGWR 304
Cdd:cd16920     7 NLVRNGIEamsEGgceRRELTIRTSPADDRAvtiSVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGGR 86

                          90
                  ....*....|....*
gi 2554591105 305 VRVTDGSTGGARFEF 319
Cdd:cd16920    87 LSVESPAGGGATFQF 101
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
26-320 9.27e-47

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 160.84  E-value: 9.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  26 FLIGAAIFTVGVRVVRRGYRPARVRRLTGWTVAGGVAGGLSLLVFSSIHTLDFGGQLVSAHLLLDGLTAGILGAGGGLVL 105
Cdd:COG0642    10 LLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 106 GLYADRLTERTRELEAANERLDEFASMVSHDLRNPLTVATLSLKLARETGEEKRFDAVDRAH---ERMGVLVDELLVLAR 182
Cdd:COG0642    90 LLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILrsaDRLLRLINDLLDLSR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 183 --QGTDITDPVPTDVEVVAREAWDTVATE----GATLVVGLE---RTVLADAERLRTLFENLYRNSIEHGRRDATVTI-- 251
Cdd:COG0642   170 leAGKLELEPEPVDLAELLEEVVELFRPLaeekGIELELDLPddlPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVsv 249

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2554591105 252 --GETATGFFVEDDGPGIDVARRGEIFAGGYTT----TEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEFE 320
Cdd:COG0642   250 rrEGDRVRISVEDTGPGIPPEDLERIFEPFFRTdpsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVT 324
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
111-321 1.43e-44

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 152.37  E-value: 1.43e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 111 RLTERTRELEAANERLDEFASMVSHDLRNPLTVATLSLKLARETG---EEKRFDAVDRAH---ERMGVLVDELLVLAR-- 182
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEdlsPEERRELLEIIResaERLLRLIEDLLDLSRle 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 183 QGTDITDPVPTDVEVVAREAWDTV----ATEGATLVVGLER---TVLADAERLRTLFENLYRNSIEHGRRDATVTIGETA 255
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELrplaEEKGIRLELDLPPelpLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2554591105 256 TG----FFVEDDGPGIDVARRGEIFA----GGYTTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEFEV 321
Cdd:COG2205   161 EGdgvrISVSDNGPGIPEEELERIFErfyrGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 31-319 7.38e-41

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 149.17  E-value: 7.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  31 AIFTVGVRVVRRGYRPARVRRLTGWTVAGGVAGGLSLLVFSSIHTLDFGGQLVSAHLLLDGLTAGILGAGGGLVLGLYAD 110
Cdd:COG4251   187 VLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEE 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 111 RLTERTRELEAANERLDEFASMVSHDLRNPL-TVATLSLKLARETGEE------KRFDAVDRAHERMGVLVDELLVLARQ 183
Cdd:COG4251   267 ELEERTAELERSNEELEQFAYVASHDLREPLrKISGFSQLLEEDYGDKldeegrEYLERIRDAAERMQALIDDLLAYSRV 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 184 GTDITDPVPTDVEVVAREAWDTVATE----GATLVVGLERTVLADAERLRTLFENLYRNSIEHGRRD--ATVTIGETATG 257
Cdd:COG4251   347 GRQELEFEPVDLNELLEEVLEDLEPRieerGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREG 426

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 258 ----FFVEDDGPGIDVARRG---EIFAGGYTTTEH-GTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEF 319
Cdd:COG4251   427 gewvFSVRDNGIGIDPEYAEkifEIFQRLHSRDEYeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYF 496
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
1-320 2.35e-36

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 134.68  E-value: 2.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105   1 MAASVGYYVVDHDDPLLDALEVTVPFLIGAAIFTVGVRVVRRGYRPARVRRLTGWTVAGGVAGGLSLLVFSSIHTLDFGG 80
Cdd:COG5002    40 LLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  81 QLVSAHLLLDGLTAGILGAGGGLVLGLYADRLTERTRELEAANERLDEFASMVSHDLRNPLTVATLSLKLARETG---EE 157
Cdd:COG5002   120 LLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAaddPE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 158 KRFDAVDRAH---ERMGVLVDELLVLAR--QGTDITDPVPTDVEVVAREAWDTVATEGA----TLVVGLER---TVLADA 225
Cdd:COG5002   200 ERREYLEIILeeaERLSRLVNDLLDLSRleSGELKLEKEPVDLAELLEEVVEELRPLAEekgiELELDLPEdplLVLGDP 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 226 ERLRTLFENLYRNSIEHGRRDATVTIGETATG----FFVEDDGPGIDVARRGEIF------AGGYTTTEHGTGLGLSIVR 295
Cdd:COG5002   280 DRLEQVLTNLLDNAIKYTPEGGTITVSLREEDdqvrISVRDTGIGIPEEDLPRIFerfyrvDKSRSRETGGTGLGLAIVK 359

                         330       340
                  ....*....|....*....|....*
gi 2554591105 296 RIARAHGWRVRVTDGSTGGARFEFE 320
Cdd:COG5002   360 HIVEAHGGRIWVESEPGKGTTFTIT 384
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 116-320 4.33e-31

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 121.22  E-value: 4.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 116 TRELEAanERLD---EFASMVSHDLRNPLTVATLSL-----KLARETGEEKR-----FDAVDRAHERMGVLVDELLVLAR 182
Cdd:COG5000   190 TELLRA--ERLAawgELARRIAHEIKNPLTPIQLSAerlrrKLADKLEEDREdleraLDTIIRQVDRLKRIVDEFLDFAR 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 183 QGTdiTDPVPTDVEVVAREAWDTVATEGATLVVGLER-------TVLADAERLRTLFENLYRNSIEHGRRDATVTIGETA 255
Cdd:COG5000   268 LPE--PQLEPVDLNELLREVLALYEPALKEKDIRLELdldpdlpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRR 345

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2554591105 256 TG----FFVEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEFE 320
Cdd:COG5000   346 EDgrvrIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIR 414
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 16-320 7.39e-28

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 111.43  E-value: 7.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  16 LLDALEVTVPFLIGAAIFTVGVRVVRRGYRPARVRRLTGWTVAGGVAGGLSLLVFSSIHTLDFGGQLVSAHLLLDGLTAG 95
Cdd:COG4191    20 LALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  96 ILGAGGGLVLGLYADRLTERTR---ELEAANERL---------DEFASMVSHDLRNPLTVATLSLKLARETGEE------ 157
Cdd:COG4191   100 ALDAEENAELEELERDITELERaeeELRELQEQLvqseklaalGELAAGIAHEINNPLAAILGNAELLRRRLEDepdpee 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 158 --KRFDAVDRAHERMGVLVDELLVLARQGTDitDPVPTDVEVVAREAWDTVATE----GATLVVGLER---TVLADAERL 228
Cdd:COG4191   180 lrEALERILEGAERAAEIVRSLRAFSRRDEE--EREPVDLNELIDEALELLRPRlkarGIEVELDLPPdlpPVLGDPGQL 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 229 RTLFENLYRNSIE--HGRRDATVTIGETATG----FFVEDDGPGIDVARRGEIFAGGYTT--TEHGTGLGLSIVRRIARA 300
Cdd:COG4191   258 EQVLLNLLINAIDamEEGEGGRITISTRREGdyvvISVRDNGPGIPPEVLERIFEPFFTTkpVGKGTGLGLSISYGIVEK 337

                         330       340
                  ....*....|....*....|
gi 2554591105 301 HGWRVRVTDGSTGGARFEFE 320
Cdd:COG4191   338 HGGRIEVESEPGGGTTFTIT 357
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
112-322 2.46e-24

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 101.46  E-value: 2.46e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 112 LTERtRELEAANERLD------EFASMVSHDLRNPLTVATLSLKLARETGEEKRF--------DAVDRAHErmgvLVDEL 177
Cdd:COG3852   116 ITER-KRLERELRRAEklaavgELAAGLAHEIRNPLTGIRGAAQLLERELPDDELreytqliiEEADRLNN----LVDRL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 178 LVLARQGTdiTDPVPTDVEVVAREAWDTVATE---GATLVVGLER---TVLADAERLRTLFENLYRNSIEHGRRDATVTI 251
Cdd:COG3852   191 LSFSRPRP--PEREPVNLHEVLERVLELLRAEapkNIRIVRDYDPslpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITI 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 252 G-ETATGFF-------------VEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIVRRIARAHGWRVRVTdgSTGGARF 317
Cdd:COG3852   269 RtRVERQVTlgglrprlyvrieVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVE--SEPGKGT 346


                  ....*
gi 2554591105 318 EFEVR 322
Cdd:COG3852   347 TFRIY 351
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 223-323 8.86e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 85.78  E-value: 8.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  223 ADAERLRTLFENLYRNSIEHGRRDATVTIGETATG----FFVEDDGPGIDVARRGEIFAGGYTTTE-----HGTGLGLSI 293
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGdhveITVEDNGPGIPPEDLEKIFEPFFRTDKrsrkiGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 2554591105  294 VRRIARAHGWRVRVTDGSTGGARFEFEVRP 323
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 112-308 3.23e-20

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 90.80  E-value: 3.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 112 LTERtRELEAANERLD------EFASMVSHDLRNPLTvatlSLK------LARETGEEKR-FDAVDRAHERMGVLVDELL 178
Cdd:COG5809   251 ITER-KKLEELLRKSEklsvvgELAAGIAHEIRNPLT----SLKgfiqllKDTIDEEQKTyLDIMLSELDRIESIISEFL 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 179 VLAR-QGTDITdpvPTDVEVVAREAWDTVATEgATL--------VVGLERTVLADAERLRTLFENLYRNSIEHGRRDATV 249
Cdd:COG5809   326 VLAKpQAIKYE---PKDLNTLIEEVIPLLQPQ-ALLknvqieleLEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNI 401

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2554591105 250 TIGETATG-----FFVEDDGPGID---VARRGEIFaggYTTTEHGTGLGLSIVRRIARAHGWRVRVT 308
Cdd:COG5809   402 TIETKAEDddkvvISVTDEGCGIPeerLKKLGEPF---YTTKEKGTGLGLMVSYKIIEEHGGKITVE 465
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
62-327 2.50e-19

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 88.49  E-value: 2.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105  62 AGGLSLLVFSSIhTLDFGGQLVSAHLLLDGLTAGilgaggglvlglyaDRLTERTRELE--AAnerLDEFASMVSHDLRN 139
Cdd:PRK11360  342 DRTIELSVSTSL-LHNTHGEMIGALVIFSDLTER--------------KRLQRRVARQErlAA---LGELVAGVAHEIRN 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 140 PLTVATLSLKLARE----TGEEKRFDAVDRAHERMGVLVDELLVLARQGTDITDPVPTD--VEVVAREAWDTVATEGATL 213
Cdd:PRK11360  404 PLTAIRGYVQIWRQqtsdPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNalVEEVLQLFQTAGVQARVDF 483

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 214 VVGLER---TVLADAERLRTLFENLYRNSIEHGRRDATVTI-----GETATGFFVEDDGPGIDVARRGEIFAGGYTTTEH 285
Cdd:PRK11360  484 ETELDNelpPIWADPELLKQVLLNILINAVQAISARGKIRIrtwqySDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK 563

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2554591105 286 GTGLGLSIVRRIARAHGWRVRVTDGSTGGA--RFEFEVRPGDGL 327
Cdd:PRK11360  564 GTGLGLALSQRIINAHGGDIEVESEPGVGTtfTLYLPINPQGNQ 607
PRK10337 PRK10337
sensor protein QseC; Provisional
 129-322 1.38e-18

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 85.86  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 129 FASMVSHDLRNPLT-------VATLSLKlaRETGEEKRFDAVDRAHERMGVLVDELLVLAR--QGTDITDPVPTDVEVVA 199
Cdd:PRK10337  240 FTSDAAHELRSPLAalkvqteVAQLSDD--DPQARKKALLQLHAGIDRATRLVDQLLTLSRldSLDNLQDVAEIPLEDLL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 200 REA----WDTVATEGATLVVGLERTvlaDAER------LRTLFENLYRNSIEHGRRDATVTIGETATGFFVEDDGPGID- 268
Cdd:PRK10337  318 QSAvmdiYHTAQQAGIDVRLTLNAH---PVIRtgqpllLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTp 394

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2554591105 269 --VARRGEIFAGGYTTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGarFEFEVR 322
Cdd:PRK10337  395 eaLARIGERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG--FEAKVS 448
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 223-322 4.34e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.56  E-value: 4.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 223 ADAERLRTLFENLYRNSIEHGRRDATVTI---GETATGFFVEDDGPGIDVARRGEIFAGGYTTTEH---GTGLGLSIVRR 296
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVtlsEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....*.
gi 2554591105 297 IARAHGWRVRVTDGSTGGARFEFEVR 322
Cdd:pfam02518  81 LVELLGGTITVESEPGGGTTVTLTLP 106
PRK09303 PRK09303
histidine kinase;
117-321 1.53e-17

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 82.31  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 117 RELEAANERL---DEFASMVSHDLRNPLTVATL---SLKLARE--------TGEEKRFDAVDRAHERMGVLVDELLVLAR 182
Cdd:PRK09303  139 QENETLLEQLkfkDRVLAMLAHDLRTPLTAASLaleTLELGQIdedtelkpALIEQLQDQARRQLEEIERLITDLLEVGR 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 183 QGTD--ITDPVPTDVEVVAREA----WDTVATEGATLVVGLER---TVLADAERLRTLFENLYRNSIEHGRRDATVTIG- 252
Cdd:PRK09303  219 TRWEalRFNPQKLDLGSLCQEVilelEKRWLAKSLEIQTDIPSdlpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSm 298

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2554591105 253 --ETA--TGFFVEDDGPGIDVARRGEIFAGGY-----TTTEhGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEFEV 321
Cdd:PRK09303  299 lhRTTqkVQVSICDTGPGIPEEEQERIFEDRVrlprdEGTE-GYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTL 375
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 112-318 2.48e-16

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 79.39  E-value: 2.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 112 LTERTR--ELEAANERLD---EFASMVSHDLRNPLTVATLSLKLARETGEEKR--FDAVDRAHERMGVLVDELLVLARQG 184
Cdd:COG5805   268 ITEKKEaeELMARSEKLSiagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEeyFDIMLSELDRIESIISEFLALAKPQ 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 185 TD----------ITDPVP--------TDVEVVArEAWDTVATegatlvvglertVLADAERLRTLFENLYRNSIEHGRRD 246
Cdd:COG5805   348 AVnkekeninelIQDVVTlleteailHNIQIRL-ELLDEDPF------------IYCDENQIKQVFINLIKNAIEAMPNG 414

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2554591105 247 ATVTIGETATGFF----VEDDGPGID---VARRGEIFaggYTTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFE 318
Cdd:COG5805   415 GTITIHTEEEDNSviirVIDEGIGIPeerLKKLGEPF---FTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFT 490
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
108-317 2.89e-16

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 79.06  E-value: 2.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 108 YADRLTERTRELEAANERLDEFASM------VSHDLRNPLTvatlSLK-LARETGEekRFDAVDRAHE----------RM 170
Cdd:PRK10364  213 WYRRYLRSRQLLQDEMKRKEKLVALghlaagVAHEIRNPLS----SIKgLAKYFAE--RAPAGGEAHQlaqvmakeadRL 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 171 GVLVDELLVLAR------QGTDITDPVPTDVEVVAREAWDTVATEGATLVVGLERtVLADAERLRTLFENLYRNSIEHGR 244
Cdd:PRK10364  287 NRVVSELLELVKpthlalQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPE-IQADPDRLTQVLLNLYLNAIQAIG 365

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2554591105 245 RDATVTIGETATG----FFVEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARF 317
Cdd:PRK10364  366 QHGVISVTASESGagvkISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATF 442
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 119-321 1.16e-15

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 77.43  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 119 LEAANERLDEFASMVSHDLRNPLT--VATLSLKLARE-TGEEKRfDAVDRA---HERMGVLVDELLVLAR--QGTDITDP 190
Cdd:TIGR01386 234 LEDAFQRLSQFSADLAHELRTPLTnlLGQTQVALSQPrTGEEYR-EVLESNleeLERLSRMVSDMLFLARadNGQLALER 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 191 VPTDVEVVAR---EAWDTVATE-GATLVVGLERTVLADAERLRTLFENLYRNSIEHGRRDATVTIG-ETATGFF---VED 262
Cdd:TIGR01386 313 VRLDLAAELAkvaEYFEPLAEErGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRiERRSDEVrvsVSN 392

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2554591105 263 DGPGIDVARRGEIF------AGGYTTTEHGTGLGLSIVRRIARAHGWRVRVT--DGSTggaRFEFEV 321
Cdd:TIGR01386 393 PGPGIPPEHLSRLFdrfyrvDPARSNSGEGTGLGLAIVRSIMEAHGGRASAEspDGKT---RFILRF 456
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
123-316 1.21e-15

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 76.55  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 123 NERLdeFASMVSHDLRNPLTVATLSLKLARETGEEKRFDAVDRAHERMGVlVDELLVLARQGTDIT----DPVP--TDVE 196
Cdd:PRK10755  136 QERL--FTADVAHELRTPLAGIRLHLELLEKQHHIDVAPLIARLDQMMHT-VEQLLQLARAGQSFSsghyQTVKllEDVI 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 197 VVAREAWDTV-ATEGATLVVGL---ERTVLADAE----RLRTLFENLYRNSIEHGrrDATVTIGETATG--FFVEDDGPG 266
Cdd:PRK10755  213 LPSQDELSEMlEQRQQTLLLPEsaaDITVQGDATllrlLLRNLVENAHRYSPEGS--TITIKLSQEDGGavLAVEDEGPG 290

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2554591105 267 IDVARRGEI------FAGGYTttehGTGLGLSIVRRIARAHGWRVRVTDGS-TGGAR 316
Cdd:PRK10755  291 IDESKCGELskafvrMDSRYG----GIGLGLSIVSRITQLHHGQFFLQNRQeRSGTR 343
PRK10604 PRK10604
sensor protein RstB; Provisional
 133-319 4.21e-15

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 75.41  E-value: 4.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 133 VSHDLRNPLtvATLSLKLA---RETGEEKRfdAVDRAHERMGVLVDELLVLA---RQGTDITdPVPTDVEVVAREAWDTV 206
Cdd:PRK10604  219 IAHELRTPL--VRLRYRLEmsdNLSAAESQ--ALNRDIGQLEALIEELLTYArldRPQNELH-LSEPDLPAWLSTHLADI 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 207 ATEGATLVVGLERTVLADA----ERL--RTLfENLYRNSIEHGRRDATVTI---GETATgFFVEDDGPGIDVARRGEIF- 276
Cdd:PRK10604  294 QAVTPEKTVRLDTPHQGDYgaldMRLmeRVL-DNLLNNALRYAHSRVRVSLlldGNQAC-LIVEDDGPGIPPEERERVFe 371

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2554591105 277 ------------AGGYtttehgtGLGLSIVRRIARAHGWRVRVTDGSTGGARFEF 319
Cdd:PRK10604  372 pfvrldpsrdraTGGC-------GLGLAIVHSIALAMGGSVNCDESELGGARFSF 419
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-319 4.42e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 70.12  E-value: 4.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 234 NLYRNSIE---HG---RRDATVTIGETATGF---FVEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIVRRIARAHGWR 304
Cdd:cd16920     7 NLVRNGIEamsEGgceRRELTIRTSPADDRAvtiSVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGGR 86

                          90
                  ....*....|....*
gi 2554591105 305 VRVTDGSTGGARFEF 319
Cdd:cd16920    87 LSVESPAGGGATFQF 101
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 112-321 8.73e-15

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 74.50  E-value: 8.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 112 LTERTrELEAANERLDEFASMV------SHDLRNPL-TVATLsLKLaRETGEEKRFdaVDRAHERMGVLVDELLVlarqg 184
Cdd:COG3290   170 FRDRT-ELERLEEELEGVKELAealraqRHDFRNHLhTISGL-LQL-GEYDEALEY--IDEISEELQELIDSLLS----- 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 185 tDITDPVptdVEVVAREAWDTVATEGATLVVG----LERTVLADAErLRTLFENLYRNSIEH------GRRDATVTIGET 254
Cdd:COG3290   240 -RIGNPV---LAALLLGKAARARERGIDLTIDidsdLPDLPLSDTD-LVTILGNLLDNAIEAveklpeEERRVELSIRDD 314

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 255 ATGFF--VEDDGPGIDVARRGEIFAGGYTT-TEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEFEV 321
Cdd:COG3290   315 GDELVieVEDSGPGIPEELLEKIFERGFSTkLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
117-319 9.72e-15

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 74.28  E-value: 9.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 117 RELEAAneRLDEFASmVSHDLRNPLTVATLSLKLARETGEEKRfdAVDRAH-------ERMGVLVDELLVLAR------- 182
Cdd:PRK11006  198 HQLEGA--RRNFFAN-VSHELRTPLTVLQGYLEMMQDQPLEGA--LREKALhtmreqtQRMEGLVKQLLTLSKieaapti 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 183 QGTDITDpVPTDVEVVAREAwDTVATEGATLV--VGLERTVLADAERLRTLFENLYRNSIEHGRRDATVTIG--ETATG- 257
Cdd:PRK11006  273 DLNEKVD-VPMMLRVLEREA-QTLSQGKHTITfeVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRwqRVPQGa 350

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2554591105 258 -FFVEDDGPGID---VARRGEIF-----AGGYTTTehGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEF 319
Cdd:PRK11006  351 eFSVEDNGPGIApehIPRLTERFyrvdkARSRQTG--GSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSF 419
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-319 5.15e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 67.07  E-value: 5.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 234 NLYRNSIEHGRRdaTVTIGETATG----FFVEDDGPGIDVARRGEIFA------GGYTTTEHGTGLGLSIVRRIARAHGW 303
Cdd:cd16939     7 NLLRNALRYAHR--TVRIALLVSGgrltLIVEDDGPGIPAAARERVFEpfvrldPSRDRATGGFGLGLAIVHRVALWHGG 84

                          90
                  ....*....|....*.
gi 2554591105 304 RVRVTDGSTGGARFEF 319
Cdd:cd16939    85 HVECDDSELGGACFRL 100
PRK15347 PRK15347
two component system sensor kinase;
111-320 7.90e-14

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 72.37  E-value: 7.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 111 RLTERTREL-------EAANERLDEFASMVSHDLRNPLTVATLSLKLARETG-EEKRFDAVDRAHE---RMGVLVDELLV 179
Cdd:PRK15347  376 KVAERTQALaeakqraEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPlTAEQMDLADTARQctlSLLAIINNLLD 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 180 LAR----QGT---DITDPVPtdvevVAREAWDTVA----TEGATL--VVGLE--RTVLADAERLRTLFENLYRNSI---E 241
Cdd:PRK15347  456 FSRiesgQMTlslEETALLP-----LLDQAMLTIQgpaqSKSLTLrtFVGAHvpLYLHLDSLRLRQILVNLLGNAVkftE 530

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 242 HGRRDATVTIGETATGFFVEDDGPGIDVARRGEIFAGGYTTTEH--GTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEF 319
Cdd:PRK15347  531 TGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHsqGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSL 610


                  .
gi 2554591105 320 E 320
Cdd:PRK15347  611 V 611
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
131-316 1.62e-13

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 70.73  E-value: 1.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 131 SMVSHDLRNPLTVATLSLKLA-RETGEEKRFDAVDRAHERMGVLVDELLVLARQGTD---ITDPVPtdvevvAREAWDTV 206
Cdd:PRK09470  248 SDISHELRTPLTRLQLATALLrRRQGESKELERIETEAQRLDSMINDLLVLSRNQQKnhlERETFK------ANSLWSEV 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 207 --------ATEGATLVV--GLER-TVLADAERLRTLFENLYRNSIEHGRRDATVTIGETATGFF--VEDDGPGIDVARRG 273
Cdd:PRK09470  322 ledakfeaEQMGKSLTVsaPPGPwPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTitVDDDGPGVPEEERE 401

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2554591105 274 EIFAGGYTTTEH------GTGLGLSIVRRIARAHGWRVRVTDGSTGGAR 316
Cdd:PRK09470  402 QIFRPFYRVDEArdresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLR 450
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 109-315 2.82e-13

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 70.49  E-value: 2.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 109 ADRLTERTR---ELEAANERLDEFASM---------VSHDLRNPLTVATLSLKLARETGEEKRFDAV-------DRAHER 169
Cdd:COG4192   404 ETEIEERKRiekNLRQTQDELIQAAKMavvgqtmtsLAHELNQPLNAMSMYLFSAKKALEQENYAQLptsldkiEGLIER 483

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 170 MGVLVDELLVLARQGTdiTDPVPTDVEVVAREAWDTVAT----EGATLVVGLERTVLADAERLRTLFENLYRNSIEHGRR 245
Cdd:COG4192   484 MDKIIKSLRQFSRKSD--TPLQPVDLRQVIEQAWELVESrakpQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVAT 561

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2554591105 246 DATVTIGETATG----FFVEDDGPGIDVARRgeIFAGGYTTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGA 315
Cdd:COG4192   562 QPQISVDLLSNAenlrVAISDNGNGWPLVDK--LFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGA 633
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 220-316 3.05e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 65.12  E-value: 3.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 220 TVLADAERLRTLFENLYRNSIEHGRRDATVTI---GETATGFFVEDDGPGIDVARRGEIFAGGY---TTTEHGTGLGLSI 293
Cdd:cd16940     6 QVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIklsADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSI 85

                          90       100
                  ....*....|....*....|...
gi 2554591105 294 VRRIARAHGWRVRVTDGSTGGAR 316
Cdd:cd16940    86 VKRIVELHGGQIFLGNAQGGGLE 108
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 135-316 5.10e-13

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 69.49  E-value: 5.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 135 HDLRNPLTVATLSLKLARE---TGEEKRF-DAVDRAHERMGVLVDELLVLAR--QGTDITDPVPTDVEVVAREAWDTVAT 208
Cdd:PRK11100  265 HELKSPLAAIRGAAELLQEdppPEDRARFtGNILTQSARLQQLIDRLLELARleQRQELEVLEPVALAALLEELVEAREA 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 209 E----GATLVVGLERT-VLADAERLRTLFENLYRNSIEHGRRDATVTI-GETATGFF---VEDDGPGI-DVA--RRGEIF 276
Cdd:PRK11100  345 QaaakGITLRLRPDDArVLGDPFLLRQALGNLLDNAIDFSPEGGTITLsAEVDGEQValsVEDQGPGIpDYAlpRIFERF 424

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2554591105 277 aggYT-----TTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGAR 316
Cdd:PRK11100  425 ---YSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVL 466
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
114-330 1.91e-12

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 68.17  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 114 ERTRELEAanerLDEFASMVSHDLRNPLTV----ATLSL-KLARETGEEKRFDAVDRAHERMGVLVDELLVLARQGTDIT 188
Cdd:PRK13837  442 EHARRLEA----VGTLASGIAHNFNNILGAilgyAEMALnKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERNT 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 189 DPVptDVEVVAREAWD--TVAT-EGATLVVGLER---TVLADAERLRTLFENLYRNSIEHGRRDATVTI----------- 251
Cdd:PRK13837  518 KPF--DLSELVTEIAPllRVSLpPGVELDFDQDQepaVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIslsraklrapk 595

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 252 ----GETATGFF----VEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEFEVRP 323
Cdd:PRK13837  596 vlshGVLPPGRYvllrVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP 675


                  ....*..
gi 2554591105 324 GDGLQVE 330
Cdd:PRK13837  676 SSKVPVA 682
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 232-316 2.19e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 62.73  E-value: 2.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 232 FENLYRNSIEHGRRDATVTIGETATG--FFVEDDGPGIDVARRGEIFAGGYTTTEH------GTGLGLSIVRRIARAHGW 303
Cdd:cd16949     5 LENVLRNALRYSPSKILLDISQDGDQwtITITDDGPGVPEDQLEQIFLPFYRVDSArdresgGTGLGLAIAERAIEQHGG 84

                          90
                  ....*....|...
gi 2554591105 304 RVRVTDGSTGGAR 316
Cdd:cd16949    85 KIKASNRKPGGLR 97
envZ PRK09467
osmolarity sensor protein; Provisional
 133-319 9.47e-12

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 65.32  E-value: 9.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 133 VSHDLRNPLTvatlSLKLARET-GEEKRF--DAVDRAHERMGVLVDELLVLARQGTDiTDPVPTDVEVVAREawdTVATE 209
Cdd:PRK09467  236 VSHDLRTPLT----RIRLATEMmSEEDGYlaESINKDIEECNAIIEQFIDYLRTGQE-MPMEMADLNALLGE---VIAAE 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 210 G------ATLVVGLERTVLADAERLRTLFENLYRNSIEHGRRDATVTIGET--ATGFFVEDDGPGIDVARRGEIFA---- 277
Cdd:PRK09467  308 SgyereiETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEgkRAWFQVEDDGPGIPPEQLKHLFQpftr 387

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2554591105 278 GGYTTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGG--ARFEF 319
Cdd:PRK09467  388 GDSARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGlsARAWL 431
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-319 3.80e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 59.26  E-value: 3.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 228 LRTLFENLYRNSIE--HGRRDATVTIGETATG----FFVEDDGPGID---VARRGEIFAGGYTTTE-HGTGLGLSIVRRI 297
Cdd:cd16921     1 LGQVLTNLLGNAIKfrRPRRPPRIEVGAEDVGeewtFYVRDNGIGIDpeyAEKVFGIFQRLHSREEyEGTGVGLAIVRKI 80

                          90       100
                  ....*....|....*....|..
gi 2554591105 298 ARAHGWRVRVTDGSTGGARFEF 319
Cdd:cd16921    81 IERHGGRIWLESEPGEGTTFYF 102
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 123-182 7.44e-11

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 57.22  E-value: 7.44e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2554591105 123 NERLDEFASMVSHDLRNPLTVATLSLKLARETGE-----EKRFDAVDRAHERMGVLVDELLVLAR 182
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLddeeqREYLERIREEAERLLRLINDLLDLSR 65
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 226-318 1.69e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 58.03  E-value: 1.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 226 ERLRTLFENLYRNSIEHGRrdATVTIGETATGFFVEDDGPGIDVARRGEIFAGGYTTTEH--GTGLGLSIVRRIARAHGW 303
Cdd:cd16954    40 ELLGNLLDNACKWCLEFVE--VTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQrpGQGLGLAIAKEIVEQYGG 117

                          90
                  ....*....|....*
gi 2554591105 304 RVRVTDGSTGGARFE 318
Cdd:cd16954   118 ELSLSDSPLGGARFE 132
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 125-182 4.61e-10

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 54.91  E-value: 4.61e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2554591105 125 RLDEFASMVSHDLRNPLTVATLSLKLARETG--EEKR--FDAVDRAHERMGVLVDELLVLAR 182
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKldEEQReyLETILRSAERLLRLINDLLDLSR 62
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 224-321 7.52e-10

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 55.58  E-value: 7.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 224 DAERLRTLFENLYRNSIEH----GRRDATVTIGETATGFF-VEDDGPGIDVARRGEIF-----AGGYTTTEH-GTGLGLS 292
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFtpdgGRIRCILEKFRLNRFLLtVSDSGPGIPPNLREEIFerfrqGDGSSTRAHgGTGLGLS 80

                          90       100
                  ....*....|....*....|....*....
gi 2554591105 293 IVRRIARAHGWRVRVTDGSTGGARFEFEV 321
Cdd:cd16925    81 IVKEFVELHGGTVTVSDAPGGGALFQVEL 109
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 125-182 9.39e-10

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 54.11  E-value: 9.39e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2554591105  125 RLDEFASMVSHDLRNPLTVATLSLKLARET--GEEKR--FDAVDRAHERMGVLVDELLVLAR 182
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTelSEEQReyLETILREAERLLRLINDLLDLSR 62
PRK10490 PRK10490
sensor protein KdpD; Provisional
 111-319 1.41e-09

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 59.28  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 111 RLTERTReLEAANERL-DEFASMVSHDLRNPLTV-----ATLSLKLARETGEEKRFDAVDRAH----ERmgvLVDELLVL 180
Cdd:PRK10490  649 ASEEQAR-LASEREQLrNALLAALSHDLRTPLTVlfgqaEILTLDLASEGSPHARQASEIRQQvlntTR---LVNNLLDM 724

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 181 AR-QGTDITdpvptdvevvAREAWDT----VATEGATLVVGLERTVLA------------DAERLRTLFENLYRNSIEHG 243
Cdd:PRK10490  725 ARiQSGGFN----------LRKEWLTleevVGSALQMLEPGLSGHPINlslpepltlihvDGPLFERVLINLLENAVKYA 794

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 244 RRDATVTIGETATGFFVE----DDGPGIDVARRGEIFA----GGYTTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGA 315
Cdd:PRK10490  795 GAQAEIGIDAHVEGERLQldvwDNGPGIPPGQEQLIFDkfarGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGA 874


                  ....
gi 2554591105 316 RFEF 319
Cdd:PRK10490  875 CFRV 878
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-314 2.27e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 53.99  E-value: 2.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 228 LRTLFENLYRNSIEHGRRDATVTIG--ETATGFFVEDDGPGIDVARRGEIFA----GGYTTTEHGTGLGLSIVRRIARAH 301
Cdd:cd16950     1 LKRVLSNLVDNALRYGGGWVEVSSDgeGNRTRIQVLDNGPGIAPEEVDELFQpfyrGDNARGTSGTGLGLAIVQRISDAH 80

                          90
                  ....*....|...
gi 2554591105 302 GWRVRVTDGSTGG 314
Cdd:cd16950    81 GGSLTLANRAGGG 93
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-317 3.68e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 53.58  E-value: 3.68e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 260 VEDDGPGIDVARRGEIFAGGYTT--TEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARF 317
Cdd:cd16943    40 VEDTGSGIDPEILGRIFDPFFTTkpVGEGTGLGLSLSYRIIQKHGGTIRVASVPGGGTRF 99
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-318 5.62e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 53.06  E-value: 5.62e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 260 VEDDGPGIDVARRGEIFAGGYTTTEHGT-GLGLSIVRRIARAHGWRVRVTDGSTGGARFE 318
Cdd:cd16915    41 VRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVRQSVERLGGSITVESEPGGGTTFS 100
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 258-321 9.71e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 52.50  E-value: 9.71e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2554591105 258 FFVEDDGPGIDVARRGEIF-----AGGYTTTEH-GTGLGLSIVRRIARAHGWRVRVT--DGStgGARFEFEV 321
Cdd:cd16922    39 FSVEDTGIGIPEEQQARLFepfsqADSSTTRKYgGTGLGLAISKKLVELMGGDISVEsePGQ--GSTFTFTL 108
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-321 1.28e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 52.07  E-value: 1.28e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2554591105 260 VEDDGPGIDVARRGEIFAGGYTTTE--HGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFEFEV 321
Cdd:cd16976    39 VRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVEEHGGRLSVANEEGAGARFTFDL 102
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 224-316 9.13e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 49.77  E-value: 9.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 224 DAERLRTLFENLYRNSIEH-----------GRRDATVTIgetatgfFVEDDGPGID---VARRGEIF---AGGYTTTEHG 286
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYtdtggklriraAQTPQEVRL-------DVEDSAPGVSddqLARLFERFyrvESSRNRASGG 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 2554591105 287 TGLGLSIVRRIARAHGWRVRVTDGSTGGAR 316
Cdd:cd16946    74 SGLGLAICHNIALAHGGTISAEHSPLGGLR 103
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
133-316 9.40e-08

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 53.10  E-value: 9.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 133 VSHDLRNPLTVATLSLKlARETGEeKRFDAVDRAHERMGV-----LVDEL--LVLARQGT-----DITDPVPTdVEVVAR 200
Cdd:PRK10549  247 ISHELRTPLAVLRGELE-AIQDGV-RKFTPESVASLQAEVgtltkLVDDLhqLSLSDEGAlayrkTPVDLVPL-LEVAGG 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 201 EAWDTVATEGATLVVGL--ERTVLADAERLRTLFENLYRNS-----------IEHGRRDATVTIgetatgfFVEDDGPGI 267
Cdd:PRK10549  324 AFRERFASRGLTLQLSLpdSATVFGDPDRLMQLFNNLLENSlrytdsggslhISAEQRDKTLRL-------TFADSAPGV 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2554591105 268 DVARRGEIFAGGYTT------TEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGAR 316
Cdd:PRK10549  397 SDEQLQKLFERFYRTegsrnrASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVS 451
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
248-318 1.26e-07

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 52.71  E-value: 1.26e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2554591105 248 TVTIGETATGFFVEDDGPGIDVARRGEIFAGGY--TTTEHGTGLGLSIVRRIARAHGWRVRVTDGSTGGARFE 318
Cdd:PRK10815  401 SARQTDEHLHIVVEDDGPGIPESKRELIFDRGQraDTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGARME 473
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-323 1.65e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 49.12  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 228 LRTLFENLYRNSIEHGRRDATVTI----GETATGFFVEDDGPGID---VARRGEIF-----AGGYTTTehGTGLGLSIVR 295
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSDTITVrwsqEESGARLSVEDTGPGIPpehIPRLTERFyrvdiERCRNTG--GTGLGLAIVK 78

                          90       100
                  ....*....|....*....|....*...
gi 2554591105 296 RIARAHGWRVRVTDGSTGGARFEFEVRP 323
Cdd:cd16952    79 HVMSRHDARLLIASELGKGSRFTCLFPS 106
glnL PRK11073
nitrogen regulation protein NR(II);
168-308 1.77e-07

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 52.01  E-value: 1.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 168 ERMGVLVDELLVLARQGTDITDPVPTDVEVVAReawdTVATEGATLVVgLER-------TVLADAERLRTLFENLYRNSI 240
Cdd:PRK11073  176 DRLRNLVDRLLGPQRPGTHVTESIHKVAERVVQ----LVSLELPDNVR-LIRdydpslpELAHDPDQIEQVLLNIVRNAL 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 241 EH-GRRDATVTIgETATGFF---------------VEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIVRRIARAHGWR 304
Cdd:PRK11073  251 QAlGPEGGTITL-RTRTAFQltlhgeryrlaaridIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGK 329


                  ....
gi 2554591105 305 VRVT 308
Cdd:PRK11073  330 IEFT 333
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-324 2.50e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 48.55  E-value: 2.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2554591105 260 VEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIVRRIARAHGWRVrvtdgstggarfEFEVRPG 324
Cdd:cd16918    48 VIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLAIAQNIVSQHGGVI------------ECDSQPG 100
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
238-330 2.58e-07

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 51.94  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 238 NSIEHG----RRDATVTI-----GETATgFFVEDDGPGIDVARRGEIFAgGYTTTEHGTGLGLSIVR-RIARAHGwrvrv 307
Cdd:COG2972   347 NAIEHGiepkEGGGTIRIsirkeGDRLV-ITVEDNGVGMPEEKLEKLLE-ELSSKGEGRGIGLRNVReRLKLYYG----- 419

                          90       100
                  ....*....|....*....|...
gi 2554591105 308 tdgstGGARFEFEVRPGDGLQVE 330
Cdd:COG2972   420 -----EEYGLEIESEPGEGTTVT 437
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 224-316 7.52e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 47.15  E-value: 7.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 224 DAERLRTLFENLYRNSIE------HGRRDATVTIGETATG---FFVEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIV 294
Cdd:cd16944     1 DTTQISQVLTNILKNAAEaiegrpSDVGEVRIRVEADQDGrivLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80

                          90       100
                  ....*....|....*....|..
gi 2554591105 295 RRIARAHGWRVRVTDGSTGGAR 316
Cdd:cd16944    81 KKIMEEHGGRISLSNREAGGAC 102
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 224-321 1.81e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 45.92  E-value: 1.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 224 DAERLRTLFENLYRNSIEHGRRDATVTIG----ETATGFFVEDDGPGI---DVARRGEIFAGGYTTTEHGT--GLGLSIV 294
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISiydeEEYLYFEIWDNGHGFseqDLKKALELFYRDDTSRRSGGhyGMGLYIA 80

                          90       100
                  ....*....|....*....|....*..
gi 2554591105 295 RRIARAHGWRVRVTDGSTGGARFEFEV 321
Cdd:cd16975    81 KNLVEKHGGSLIIENSQKGGAEVTVKI 107
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-317 1.47e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 43.33  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 228 LRTLFENLYRNSIEHGRRDA---TVTIGETATGF--FVEDDGPGIDVARRGEIFAGGYTTTEHG------TGLGLSIVRR 296
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDTgriTVSAMPTGKMVtiSVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQ 80

                          90       100
                  ....*....|....*....|....*
gi 2554591105 297 IARAHGWRV----RVTDGSTGGARF 317
Cdd:cd16953    81 IIEAHGGISvaenHNQPGQVIGARF 105
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 217-317 1.60e-05

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 46.44  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 217 LERTVLADAERLRTLFENLYRNSIEHGRRDA-TVTIGETATGFF--VEDDGPGIDVARRGEIFAG--GYTTTEHGTGLGL 291
Cdd:PRK11466  551 LPTALMGDPRRIRQVITNLLSNALRFTDEGSiVLRSRTDGEQWLveVEDSGCGIDPAKLAEIFQPfvQVSGKRGGTGLGL 630

                          90       100
                  ....*....|....*....|....*.
gi 2554591105 292 SIVRRIARAHGWRVRVTDGSTGGARF 317
Cdd:PRK11466  631 TISSRLAQAMGGELSATSTPEVGSCF 656
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 113-322 2.78e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 45.70  E-value: 2.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 113 TERTR---ELEAANERLDEFASMVSHDLRNPLT-VATLS-LKLARETGEEKR----------------------FDAVDR 165
Cdd:PRK11091  267 TERKRyqdALEKASRDKTTFISTISHELRTPLNgIVGLSrILLDTELTAEQRkylktihvsaitlgnifndiidMDKMER 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 166 ahermgvlvdELLVLARQGTDITDPVpTDVEVVAReawdtVATEGATLVVGLERT------VLADAERLRTLFENLYRNS 239
Cdd:PRK11091  347 ----------RKLQLDNQPIDFTDFL-ADLENLSG-----LQAEQKGLRFDLEPLlplphkVITDGTRLRQILWNLISNA 410

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 240 I---EHGRRDATV--TIGETATgFFVEDDGPGIDVARRGEIFAGGYTTTEH-------GTGLGLSIVRRIARAHGWRVRV 307
Cdd:PRK11091  411 VkftQQGGVTVRVryEEGDMLT-FEVEDSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITV 489

                         250
                  ....*....|....*
gi 2554591105 308 TDGSTGGARFEFEVR 322
Cdd:PRK11091  490 TSEEGKGSCFTLTIH 504
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
125-308 3.50e-05

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 45.15  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 125 RLDEFASMVSHDLRNPLT--VATLSLKLARETGEEKRFDAVDRAHE---RMGVLVDELLVLARQGTD--ITDPVPTDV-- 195
Cdd:PRK09835  261 RQSNFSADIAHEIRTPITnlITQTEIALSQSRSQKELEDVLYSNLEeltRMAKMVSDMLFLAQADNNqlIPEKKMLDLad 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 196 EVVAR----EAWdtvATE-GATL-VVGLERTVLADAERLRTLFENLYRNSIEH---GRRdATVTIGETATGFFVEDDGPG 266
Cdd:PRK09835  341 EVGKVfdffEAW---AEErGVELrFVGDPCQVAGDPLMLRRAISNLLSNALRYtpaGEA-ITVRCQEVDHQVQLVVENPG 416

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2554591105 267 IDVA-------------------RRGEifaggytttehGTGLGLSIVRRIARAHGWRVRVT 308
Cdd:PRK09835  417 TPIApehlprlfdrfyrvdpsrqRKGE-----------GSGIGLAIVKSIVVAHKGTVAVT 466
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 224-314 3.11e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 39.75  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 224 DAERLRTLFENLYRNSIEHGRRDATVTIGETATG----FFVEDDGPGIDVARRGEIFAGGYT-----TTEHGTGLGLSIV 294
Cdd:cd16945     1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTegieLLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFV 80

                          90       100
                  ....*....|....*....|
gi 2554591105 295 RRIARAHGWRVRVTDGSTGG 314
Cdd:cd16945    81 QEVAQLHGGRITLRNRPDGV 100
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-307 5.36e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 39.42  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 222 LADAERLRTLFENLYRNSIEHGR--RDATVTIGETATGFF--VEDDGPGIDVARRGEIFAGGYTTTE------HGTGLGL 291
Cdd:cd16947    15 NANTEALQRILKNLISNAIKYGSdgKFLGMTLREDEKHVYidIWDKGKGISETEKDHVFERLYTLEDsrnsakQGNGLGL 94

                          90
                  ....*....|....*.
gi 2554591105 292 SIVRRIARAHGWRVRV 307
Cdd:cd16947    95 TITKRLAESMGGSIYV 110
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
224-304 8.72e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 38.74  E-value: 8.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554591105 224 DAERLRTLFENLYRNSIEHGRRDA-----TVTIGETATGFFVE--DDGPGIDVARRGEIFaggytTTEHGTGLGLSIVRR 296
Cdd:COG2172    31 DADDLVLAVSEAVTNAVRHAYGGDpdgpvEVELELDPDGLEIEvrDEGPGFDPEDLPDPY-----STLAEGGRGLFLIRR 105


                  ....*...
gi 2554591105 297 IARAHGWR 304
Cdd:COG2172   106 LMDEVEYE 113
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 260-295 8.82e-04

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 41.05  E-value: 8.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2554591105 260 VEDDGPGIDVARRGEIFAGGYTTTEHGTGLGLSIVR 295
Cdd:PRK11086  472 VSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVK 507
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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