|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
6-522 |
3.73e-131 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 391.80 E-value: 3.73e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 6 STWAPLRSPVFRALWIAQFVSNLGTWMQMVGAQWMLVGDPRAAVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIAT 85
Cdd:pfam05977 2 SPLAPLRQGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 86 QGAMASTVGLLAVLTGVGLTTPTVLLLLLFLIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGA 165
Cdd:pfam05977 82 QLLLALVSTLLTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 166 LVSVSGPTVVFGLNAVSFVGTVIVLVLWRRPPDEQNFPSERALAALSAGGRYIRSSPIVRRILLRTALFIGPASALWGLL 245
Cdd:pfam05977 162 LLAAFGPAFTFALNALSYFAVIAALWRWKRAAPASPLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 246 PVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAW 325
Cdd:pfam05977 242 PLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAW 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 326 LLCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQALGSLVWGLLAGAASPVSSLLVSVGLLVACAVSTLWWPLhAKTGD 405
Cdd:pfam05977 322 ITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLRFRL-PEGEA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 406 IDLSPSSHWPEPSLVIEPEPLDGPVLVLTDYHVTAADEPEFLAAMAVLGRSRQRTGAARWRLYRSVEREQTFVETFIVRS 485
Cdd:pfam05977 401 ADLIPSNHWPEPLVALAVKPRRGPVLVLIEYSIDKEDIPAFLKAMAELRRERRRDGAYGWGLTRDLANPEVWVETFMVES 480
|
490 500 510
....*....|....*....|....*....|....*....
gi 2556353321 486 WGEHLHQHHtRQTGQDQVIEQAVERFVES--RPVAHHLI 522
Cdd:pfam05977 481 WAEHLRHHQ-RVTAADADVQDKVTAFHSGkePPQVRHSL 518
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-396 |
3.47e-70 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 229.42 E-value: 3.47e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 16 FRALWIAQFVSNLGTWMQMVGAQWMLVGDPRAAVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGL 95
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 96 LAVLTGVGLTTPTVLLLLLFLIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVV 175
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 176 FGLNAVSFVGTVIVLVLWRRPPDEQN-FPSERALAALSAGGRYIRSSPIVRRILLRTALFIGPASALWGLLPVIADRKLG 254
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPgESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 255 LTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNA 334
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2556353321 335 SMQLSLPGWVRARGLSVYQLIFMGGQALGSLVWGLLAGAASPVSSLLVSVGLLVACAVSTLW 396
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-362 |
1.48e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.00 E-value: 1.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 6 STWAPLRSPVFRALWIAQFVSNLGTWMQMVGAQWMLVGDPRAAVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIAT 85
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 86 QGAMASTVGLLAVLTGVGLTTPTVLLlllflIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGA 165
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFL-----QGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 166 LVSVSGPTVVFGLNAVSFVgtVIVLVLWRRPPDEQNFPSERALAALSAggryIRSSPIVRRILLRTALFIGPASALWGLL 245
Cdd:COG2814 157 LADLFGWRWVFLVNAVLAL--LALLLLLRLLPESRPAARARLRGSLRE----LLRRPRLLLLLLLAFLLGFGFFALFTYL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 246 PVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAW 325
Cdd:COG2814 231 PLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGF 310
|
330 340 350
....*....|....*....|....*....|....*..
gi 2556353321 326 LLCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQAL 362
Cdd:COG2814 311 GLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
16-371 |
5.68e-25 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 106.25 E-value: 5.68e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 16 FRALWIAQFVSNLGTWMQMVGAQWMLVGDPRAAVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGL 95
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 96 LAVLTGVGLTTPTVLLLLLFLIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVV 175
Cdd:TIGR00900 81 LPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 176 FGLNAVSFVGTVIVLVL----WRRPPDEQNFpSERALAALSAGGRYIRSSPIVRRI----LLRTALFIGPASAlwgLLPV 247
Cdd:TIGR00900 161 IWVDAVGFAISALLIVSvripELAASEIQAL-SNAVLRDTREGIKFVLKNPLLRTLlllaLLFNLVFAPAIVA---LFPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 248 IADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENILLTIAATGFAAATAVLALVN-NFAVVLIALVFGGTAWL 326
Cdd:TIGR00900 237 VQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVGLTPpNFPLFLVLWFAIGVGYG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2556353321 327 LCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQALGSLVWGLLA 371
Cdd:TIGR00900 317 PINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLA 361
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-364 |
3.99e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.79 E-value: 3.99e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 19 LWIAQFVSNLGTWMQMVGAQWMLVGDPRAAV-LVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGLLA 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPtEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 98 VLTGVglttpTVLLLLLFLIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFG 177
Cdd:pfam07690 81 FASSL-----WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 178 LNAVSFVGTVIVLVLWRRPPDEQNFPSERALAALSAGGRYIRSSPIVRRILLRTALFIGPASALWGLLPVIADRkLGLTS 257
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 258 SGYGLMLGALGLGAVLGAIALSRLRSRFGENILLTIAATGFAAATAV---LALVNNFAVVLIALVFGGTAWLLCLSTLNA 334
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGlllLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
|
330 340 350
....*....|....*....|....*....|
gi 2556353321 335 SMQLSLPGWVRARGLSVYQLIFMGGQALGS 364
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-397 |
4.40e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.87 E-value: 4.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 48 AVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAVLTGVGLTTPTVLLLllfliGCGQALTMPA 127
Cdd:cd17325 30 VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQ-----GLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 128 WQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLWRRPPDEQNFPSERA 207
Cdd:cd17325 105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 208 LAALSAGGRYIRSSPIVRRILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGE 287
Cdd:cd17325 185 AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 288 NILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQALGSLVW 367
Cdd:cd17325 265 KPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLG 344
|
330 340 350
....*....|....*....|....*....|
gi 2556353321 368 GLLAGAASPVSSLLVSVGLLVACAVSTLWW 397
Cdd:cd17325 345 GFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
10-392 |
3.56e-15 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 77.71 E-value: 3.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 10 PLR-SPVFRALWIAQFVSNLGTWMQMVG--AQ-WMLVGDPraaVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIAT 85
Cdd:PRK10489 12 LLKtHPAFRAVFIARFISIFGLGLLGVAvpVQiQMMTGST---LQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 86 QGAMASTVGLLAVLTGVGLTTPTVLLLLLFLIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGA 165
Cdd:PRK10489 89 RGTCGLGFIGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 166 LVSVSGPTVVFGLNAvsfVGTVIVLV-LWRRPPDE-QNFPSERALAALSAGGRYIRSSPIVRRILLRTALfIGPASALWG 243
Cdd:PRK10489 169 LIAAGGVAWNYGLAA---AGTFITLLpLLRLPALPpPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGL-LTMASAVRV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 244 LLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRL-RSRFGENILLTIAATGFAAATAVLALVNNFAVVLIALVFGg 322
Cdd:PRK10489 245 LYPALADEVWQMGAAQIGLLYAAVPLGAALGALTSGWLaHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFG- 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2556353321 323 taWLLCLSTL--NASMQLSLPGWVRARGLSVYQLIFMGGQALGSLVWGLLAGAASPVSSLLVS-VGLLVACAV 392
Cdd:PRK10489 324 --YLSAISSLlqYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASgFGLLIIGVL 394
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-395 |
7.24e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 67.07 E-value: 7.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 19 LWIAQFVSNLGTWMQMVGAQWMLVGDPRAAVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAV 98
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 99 LTGVGLTTPTVLLlllflIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPT--VVF 176
Cdd:cd06174 81 APSFWLLLLGRFL-----LGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 177 GLNAVSFVGTVIVLVLW-RRPPDEQNFPSERALAALSAGG-RYIRSSPIVRRILLRTALFIGPASALWGLLPVIADRKLG 254
Cdd:cd06174 156 LIAAALALLAAILLLLVvPDPPESARAKNEEASSKSVLKLlKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 255 LTSSGYGLMLGALGLGAVLGAIALSRLRSRFGE--NILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTL 332
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGrkPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2556353321 333 NASMQLSLPGWvRARGLSVYQLIFMGGQALGSLVWG-LLAGAASPVSSLLVSVGLLVACAVSTL 395
Cdd:cd06174 316 ALIAELFPPEI-RGTAFGLLNTFGFLGGAIGPLLAGfLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
17-397 |
4.55e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.56 E-value: 4.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 17 RALWIAQFVSNLGTWM----------QMVGAQWMLVGdpraavLVPLVQTATTLPVMLLAlpsGVLADLIDRRRLLIATQ 86
Cdd:cd17329 2 WVLLIGSFLNRLGFFMvwpfmaiylhQQLGLSASIVG------LVLALSAVAGIVASLIG---GRLADRFGRKPVMLAGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 87 GAMASTVGLLAVLTGVGLTTPTVLLlllflIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGAL 166
Cdd:cd17329 73 LLRALGFALLGFAHSPWLFAIALVL-----TGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 167 VsVSGPTVVFGLNAVSFVGTVIVLVLWRRPpdeqNFPSERALAALSAGGRYIRSspIVRRILLRTALFIGPASALWG--- 243
Cdd:cd17329 148 L-LYSFRLLFLAAAVLFLLAALVLLFLLPE----TRPKRRAAEKTEILRGYKIV--LRDRAFLLFLLASFLISLIYFqle 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 244 -LLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENILLTIAATGFAAATAVLALVNNFAVVLIALVFGG 322
Cdd:cd17329 221 sTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLT 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2556353321 323 TAWLLCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQALGSLVWGLLAGAASPvSSLLVSVGLLVACAVSTLWW 397
Cdd:cd17329 301 LGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGP-GLPWLILAALGLIAAALLLG 374
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
51-392 |
6.23e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.13 E-value: 6.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 51 VPLVQTATTLPVMLLALPSGVLADLIDRRRLLI---------ATQGAMASTVGLLAVLTGVGlttptvlllllfliGCGQ 121
Cdd:cd17474 36 VGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLpglllfgigGLLCGLSDSFALLLAGRALQ--------------GIGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 122 ALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLWRRPPDEQN 201
Cdd:cd17474 102 AGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 202 FPSERALAALSAggryIRSSPIVRRILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSR- 280
Cdd:cd17474 182 SSSATKLRDLKK----ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRl 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 281 LRSRFGENILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQ 360
Cdd:cd17474 258 LKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQ 337
|
330 340 350
....*....|....*....|....*....|..
gi 2556353321 361 ALGSLVWGLLAGAASPVSSLLVSVGLLVACAV 392
Cdd:cd17474 338 AVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
56-395 |
3.45e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.80 E-value: 3.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 56 TATTLPVMLLALPSGVLADLIDRRRLLIATqgamastVGLLAVLTGVGLTTPTVLLLLLFLIGCGQALTMpAWQAIQP-- 133
Cdd:cd17324 41 SAYALGYALGALLLGPLSDRIERRRLLLVL-------LLLFILGNLLAALAPSFALLLLARALAGLAHGG-FWAIAAAya 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 134 -DLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGlnAVSFVGTVIVLVLWRRPPDEQNFPSeRALAALS 212
Cdd:cd17324 113 aDLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL--AIAVLALLAALLLWRLLPSLPPKKP-GSLGLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 213 AGGRyIRSSPIVRRILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENILLT 292
Cdd:cd17324 190 SLLL-LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 293 IAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGwVRARGLSVYQLIFMGGQALGSLVWGLLAG 372
Cdd:cd17324 269 ALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLYLAAYNLGGALGAALGGLVLD 347
|
330 340
....*....|....*....|...
gi 2556353321 373 AASPVSSLLVSVGLLVACAVSTL 395
Cdd:cd17324 348 HGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
48-397 |
1.02e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.30 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 48 AVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAVLTGVGLTTPTVLLLllfliGCGQALTMPA 127
Cdd:cd17489 30 EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIH-----GIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 128 WQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAV-SFVGTVIVLVLWRRPPDeqnfPSER 206
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVlALLALLLVFLVKDPPPV----AAEE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 207 ALAALSAGGRYIRssPIVRRILLRTALFIGPASALWGLLPVIAdRKLGLTSSGYGLMLGALGLgaVLGAIALSRLRSRFG 286
Cdd:cd17489 181 AEAGTRAFRRLVE--KKVLPPALILFLASIAYGAISTFLPLYA-AERGISNAGLFFTVYAIAL--LLSRPFSGKLSDRKG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 287 ENILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQALGSLV 366
Cdd:cd17489 256 PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLL 335
|
330 340 350
....*....|....*....|....*....|.
gi 2556353321 367 WGLLAGAASPVSSLLVSVGLLVACAVSTLWW 397
Cdd:cd17489 336 LGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
45-398 |
6.22e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.97 E-value: 6.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 45 PRAAVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIA---------TQGAMASTVGLLAVLTGVglttptvlllllf 115
Cdd:cd17473 31 PNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAglllygiggVAGLFLDSLYALLASRAL------------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 116 lIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVS--GPtvvFGLNAVSFVgtVIVLVLW 193
Cdd:cd17473 98 -LGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGwrAP---FLVYLLALP--VLILVLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 194 R-RPPDEQNFPSERALAALSAGGRYIRSSPIVRRILLRTALFIGPASALwgllPVIADRKLGLTSSGYGLMLGALGLGAV 272
Cdd:cd17473 172 FlPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQL----PFLLQERGGGSAALIGLALAIASLAGA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 273 LGAIALSRLRSRFGENILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGWVRARGLSVY 352
Cdd:cd17473 248 IGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIV 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2556353321 353 QLIFMGGQALGSLVWGLLAGAASPVS-SLLVSVGLLVACAVSTLWWP 398
Cdd:cd17473 328 TSAFFLGQFLSPLVLGPLVNLTGGLSgAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
56-194 |
1.11e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.20 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 56 TATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAVLTGVglttpTVLLLLLFLIGCGQALTMPAWQAIQPDL 135
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF-----WLLLLLLALLGLGLGLVFPATLALLADI 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2556353321 136 VPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLWR 194
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
53-398 |
2.95e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.65 E-value: 2.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 53 LVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAVLTGVGLTTPTVLLlllflIGCGQALTMPAWQAIQ 132
Cdd:COG2271 49 LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFL-----LGLGEAGFFPAALKLI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 133 PDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLWrrppdeqnfpseralaals 212
Cdd:COG2271 124 AEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWL------------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 213 aggryirsspivrrILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGE--NIL 290
Cdd:COG2271 185 --------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 291 LTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQALGSLVWGLL 370
Cdd:COG2271 251 LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
330 340
....*....|....*....|....*...
gi 2556353321 371 AGAASPVSSLLVSVGLLVACAVSTLWWP 398
Cdd:COG2271 331 LDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-192 |
2.05e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.37 E-value: 2.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 8 WAPLRSPVFRALWIAQFVSNLGTWMQMVGAQWML---VGDPRAavLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIA 84
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFkyvLGLSAA--LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 85 tqgAMASTVGLLAVLTGVGLTTPTVLLLLLFLIGCGQALTMPAWQAIQPDLVPAHQIP-------AAAALGSMSMNGARA 157
Cdd:COG2211 300 ---GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQA 376
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2556353321 158 IGPAIAGALVSVSG--------PTVVFGLNAVSFVGTVIVLVL 192
Cdd:COG2211 377 LAGALAGLLLALFGyvagaaqsPSALTGIRLLFFLLPAVLLLL 419
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
53-396 |
3.81e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.16 E-value: 3.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 53 LVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAVLTGVGLTTPTVLLlllflIGCGQALTMPAWQAIQ 132
Cdd:COG0738 47 LLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFL-----LGLGLGLLDVAANPYV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 133 PDLVPAHQIPAAAALGSMSMNGArAIGPAIAGALVSVS-GPTVVFGLNAVSFVGTVIVLVLWRRPPDEQNFPSERAlAAL 211
Cdd:COG0738 122 AALGPETAASRLNLLHAFFSLGA-LLGPLLGGLLILLGlSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEA-AGS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 212 SAGGRYIRSSPIVRRILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENILL 291
Cdd:COG0738 200 AASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 292 TIAATGFAAATAVLALVNNFAVVLIALVFGGtawlLCLSTLNASMQ---LSLPGWVRARGLSVYQLIFMGGQALGSLVWG 368
Cdd:COG0738 280 RLSALLAAVGLLLALLAPGPWLALIGLALVG----LGLSLMFPTIFslaLDGLGKRTAAAVSAVLIMGIVGGAIGPPLIG 355
|
330 340
....*....|....*....|....*...
gi 2556353321 369 LLAGAASPVSSLLVSVGLLVACAVSTLW 396
Cdd:COG0738 356 FLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-285 |
1.38e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.19 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 1 MSSPVSTWAPLRSPVFRALWIAQFVSNLGTWMQMVGAQWMLVGDPRAAVLVPLVQTATTLPVMLLALPSGVLADLIDRRR 80
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 81 LLIATQGAMASTVGLLAVLTGVGLTTPTVLLLllfliGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGP 160
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQ-----GIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 161 AIAGALVSVSGPTVVFGLNAVsfVGTVIVLVLWRRPPDEQNFPSERALAALSAGGRYIRSSPIVRRILLRTALFIGPASA 240
Cdd:COG0477 156 LLGGLLVAALGWRWIFLINAP--LGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALL 233
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2556353321 241 LWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRF 285
Cdd:COG0477 234 LAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLAL 278
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
53-199 |
7.62e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.33 E-value: 7.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 53 LVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAVLTgvgLTTPTVLLLLLFLIGCGQALTMPAWQAIQ 132
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAL---LPSPALAIALLFLAGFGLGGAFGLLWALA 296
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2556353321 133 PDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLWRRPPDE 199
Cdd:COG2271 297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
118-397 |
1.18e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 47.57 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 118 GCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVsfVGTVIVLVLWRRPP 197
Cdd:cd17320 98 GLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLAL--LGLLLLLLVLLFLP 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 198 dEQNFPSERALAALSAGGRYIR--SSPIVRRILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGA 275
Cdd:cd17320 176 -ETLPEEKRKPLLSSLLRAYKRvlKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGS 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 276 IALSRLRSRFGE-------NILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLclsTLNASMQLSLPGWVRARG 348
Cdd:cd17320 255 LLNGRLVRRFGPrrllrlgLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIF---PNATSLALEPFPHVAGTA 331
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2556353321 349 LSVYQLIFMGGQALGslvwGLLAGAASPVSSLLVSVGLLVACAVSTLWW 397
Cdd:cd17320 332 SALLGFLQFLIGALA----GALVGLLPNGTALPMGLLILVLGLLALLLL 376
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
56-194 |
2.04e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 56 TATTLPVMLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAVLTGVglttpTVLLLLLFLIGCGQALTMPAWQAIQPDL 135
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSP-----WMLLLAAVLYGLGFGLLFPALQALAVDL 308
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2556353321 136 VPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLWR 194
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
70-387 |
3.51e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.06 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 70 GVLADLIDRRRLLIATQGAMASTVGLLAVLTGVglttptvlllLLFLIGCGQAL---TMPAWQAIQPDLVPAHQipAAAA 146
Cdd:cd17331 56 GRFGDLFGPRAALVLSFLSSALSYLLLAFASSV----------PMLFLSRLPSVfmhAMQAAQMVVTDLTDPGE--RAAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 147 LG--SMSMNGARAIGPAIAGALVSVSGPTVVFGLNAV-SFVGTVIVLVLWRRPP-----DEQNFPSERALAALSAGGRYI 218
Cdd:cd17331 124 LGrlGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVgSLLSIVLVILLIPSNTkskreKEAKESASPPSVFNLKEILRL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 219 RSSPIVRRILLRTALFIGPASALWGLLPVIADRKLGLTSS--GYGLMLGALGLGaVLGAIALSRLRSRFGENILLTIAAT 296
Cdd:cd17331 204 LRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEenGYLMSYAGVLGM-VVQGLLVGPLTKRFGERSLLKLSVA 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 297 GFAAATAVLALVNN---FAVVLIALVFGGTAWLLCL-STLNASMQLSLPGWVRARGLSVYQLIFMGGQALGSLV-----W 367
Cdd:cd17331 283 LLAIGYLLLAFVTTvwqLLVLLLPLVIGGSVLYTVItSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALlqaygF 362
|
330 340
....*....|....*....|
gi 2556353321 368 GLLAGAASPVSSLLVSVGLL 387
Cdd:cd17331 363 PSFGLLGAAINGLLTVYLLL 382
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
54-403 |
9.19e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.87 E-value: 9.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 54 VQTATTLPV---MLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAVLTGVGLTTPTVLLlllflIGCGQALTMPAWQA 130
Cdd:COG2223 42 LGLLFAIPVlvgALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL-----LGIGGGGSFAVGIA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 131 IQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLW-RRPPDEQNFPSERALA 209
Cdd:COG2223 117 LVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFlRDPPAGAAAAAKASLR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 210 ALSAggryIRSSPIVRRILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENI 289
Cdd:COG2223 197 DQLE----ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 290 LLTIAATGFAAATAV-LALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGWVRArglSVYQLIFMGGqALGSLVWG 368
Cdd:COG2223 273 VLLIVFALMALGLLLlALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAG---AVYGLVGAAG-GLGGFLGP 348
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2556353321 369 LLAGAA-----SPVSSLLVSVGLLVACAVSTLWWPLHAKT 403
Cdd:COG2223 349 LLFGALldatgSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
47-396 |
1.23e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.49 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 47 AAVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIAtqgamaSTVGLLAVLTGVGLTTPTVLLLLLFLIGCGQALTMP 126
Cdd:cd17330 32 SGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLL------SLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 127 AWQAIQPDLVPAHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLWRRPpdeqnfpser 206
Cdd:cd17330 106 VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPP---------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 207 alaalsaggryirsspiVRRILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIAL-SRLRSRF 285
Cdd:cd17330 176 -----------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 286 GENILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQALGSL 365
Cdd:cd17330 239 GERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPL 318
|
330 340 350
....*....|....*....|....*....|.
gi 2556353321 366 VWGLLAGAASPVSSLLVSVGLLVACAVSTLW 396
Cdd:cd17330 319 LAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
227-419 |
1.10e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 227 ILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENILLTIAATGFAAATAVLA 306
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 307 LVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGWVRARGLSVYQLIFMGGQALGSLVWGLLAGAASPVSSLLVSVGL 386
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190
....*....|....*....|....*....|...
gi 2556353321 387 LVACAVSTLWWPLHAKTGDIDLSPSSHWPEPSL 419
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA 193
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
41-396 |
1.14e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 41.83 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 41 LVGDPRAAVLVPLVQTATTLPVMLLALPSGVLADLIDRRRLLIATQgamASTVGL-LAVLTGVGLTTPTVLLLLLFLIGC 119
Cdd:PRK08633 39 AYDGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVK---LFEVGLtLLIVLAYYLGWFWLAFAVTFLLGA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 120 GQALTMPAWQAIQPDLVPAHQ---------------IPAAAALGSMSMNGARAIGPAIAGALVSVSGptvvFGLNAVSFV 184
Cdd:PRK08633 116 QSAIYSPAKYGIIPELVGKENlsranglleaftivaILAGTALFSFLFESVNGNTPSEILGRIAPAG----LVLLAVAVL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 185 GTVIVLVLWRRPPDEQNFPSERA---LAALSAGGRYIRSSPIVRRILLRTALFIGPASALWGLLPVIADRKLGLTSSGYG 261
Cdd:PRK08633 192 GLIFAYRLPKVPAAAPEVFDKKKylfPKLLWRNLKLLRSDRVLWLAIIGLSYFWFISQLAQANFPAYAKEVLGLDNTFQV 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 262 LMLGALGLGAV-LGAIALSRLRSRFGENILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSL 340
Cdd:PRK08633 272 QYLLAASAIGIgIGSLLAGRLSGRHIELGLVPLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRA 351
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 341 PGWVRARGL---SVYQLIFMGgqaLGSLVWGLLAGAASPVSSLLVSVGLL-VACAVSTLW 396
Cdd:PRK08633 352 PEKELGKVLaanNFLQNVGML---LFLALTTLFSGLGLSPAGLFYLIALVtLIGTLYTLL 408
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
122-398 |
1.40e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 122 ALTMPAWQAIQPDLVP-AHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLW------- 193
Cdd:COG2211 125 TLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFlltffgt 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 194 --RRPPDEQNFPSERALAALsaggryiRSSPIVRRILLRTALFIGPASALWGLLPVIADRKLGLTSSGYGLMLGALGLGA 271
Cdd:COG2211 205 keRPVPEEEKVSLKESLKAL-------LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 272 VLGAIALSRLRSRFG--ENILLTIAATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASM-----QLSLPGWV 344
Cdd:COG2211 278 LLGAPLWPRLAKRFGkkKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdYDEWKTGR 357
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2556353321 345 RARGL--SVYQLIFMGGQALGSLVWGLLAGAASPVSSLLVSVGLLVACAVSTLWWP 398
Cdd:COG2211 358 RREGLyfGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLLP 413
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-199 |
1.40e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.02 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 2 SSPVSTWAPLRSPVFRALWIAQFVSN-----LGTWMQMVGAQWMLVGDPRAAVLVPLVqtatTLPVMLLALPSGVLADLI 76
Cdd:COG2223 193 ASLRDQLEALRDPRFWLLSLLYFGTFgsfigFSSWLPPYLVDQFGLSAATAGLLAALF----ALLGALGRPLGGWLSDRI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 77 DRRRLLIATQGAMASTVGLLAVLTGVGLTTPTVLLLLLFLIGCGQALTMpawqAIQPDLVPAHQIPAAAALGSMSMNGAR 156
Cdd:COG2223 269 GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVF----ALVPDIFPTKNAGAVYGLVGAAGGLGG 344
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2556353321 157 AIGPAIAGALVSVSGP-----TVVFGLNAVSFVGTVIVLVLWRRPPDE 199
Cdd:COG2223 345 FLGPLLFGALLDATGSytaafLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
2-191 |
1.90e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.49 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 2 SSPVSTWAPLRSPVFRALWIAQFVSNLG--TWMQMVGAQWMLVGDPRAAVlVPLVQTATTLPVMLLALPSGVLADLIDRR 79
Cdd:cd06174 191 SVLKLLKRVLKNPGLWLLLLAIFLVNLAyySFSTLLPLFLLDLGGLSVAV-AGLLLSLFGLAGALGSLLLGLLSDRLIGR 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 80 RLLIATQGAMASTVGLLAVLtgvgLTTPTVLLLLLFLIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGARAIG 159
Cdd:cd06174 270 KPLLLIGLLLMALGLALLLL----APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIG 345
|
170 180 190
....*....|....*....|....*....|...
gi 2556353321 160 PAIAGAL-VSVSGPTVVFGLNAVSFVGTVIVLV 191
Cdd:cd06174 346 PLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-200 |
2.33e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 2 SSPVSTWAPLRSPVFRALWIAQFVSNL-----GTWMQMVGAQWMLVGDPRAAVLVplvqTATTLPVMLLALPSGVLADLI 76
Cdd:COG0738 198 GSAASLKSLLKNPRLLLGGLAIFLYVGaegaiGDWLPLYLKDVLGLSEATAALGL----SLFWGGMTIGRFLGGFLLKRF 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 77 DRRRLLIAtqGAMASTVGLLAVLTGVGLTTPTVLLLLlflIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGAr 156
Cdd:COG0738 274 GPVRLLRL--SALLAAVGLLLALLAPGPWLALIGLAL---VGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGG- 347
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2556353321 157 AIGPAIAGALVSVSGPTVVFGLNAVSFVGTVIVLVLWRRPPDEQ 200
Cdd:COG0738 348 AIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
58-396 |
3.56e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.86 E-value: 3.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 58 TTLPV---MLLALPSGVLADLIDRRRLLIATQGAMASTVGLLAVLTGVGLTTPTVLLlllflIGCGQALTMPAWQAIQPD 134
Cdd:COG2807 59 TTLPLlafGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL-----IGAGIAVGNVLLPGLIKR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 135 LVPaHQIPAAAALGSMSMNGARAIGPAIAGALVSVSGPTVVFGLNAV-SFVGTVIVLVLWRRPPdeqnfpSERALAALSA 213
Cdd:COG2807 134 WFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALlALLALLLWLPLLRRRP------AAAAAAPAAA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 214 GGRYIRSSPIVRRILLRTALFIGPASALWGLLPVIAdRKLGLTSSGYGLMLGALGLGAVLGAIALSRLRSRFGENILLTI 293
Cdd:COG2807 207 SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 294 AATGFAAATAVLALVNNFAVVLIALVFGGTAWLLCLSTLNASMQLSLPGWVRARGLS-VYQLIFMGGQALGSLVWGLLAG 372
Cdd:COG2807 286 LLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSgMAQSVGYLLAALGPLLVGALHD 365
|
330 340
....*....|....*....|....*
gi 2556353321 373 AA-SPVSSLLVSVGLLVACAVSTLW 396
Cdd:COG2807 366 ATgSWTAALLLLAALAVLMLVAGLL 390
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-198 |
4.39e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.53 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 18 ALWIAQF-----VSNLGTWMQMVGAQWmlvGDPRAAVLVPlvqTATTLPVMLLALPSGVLADLIDRRRLLIATQ------ 86
Cdd:cd06179 2 ALCLAYFaqlfgVTLPAAVLPFIVADL---GPSSNSTWIS---TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNllgvvg 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556353321 87 ---GAMASTVGLLAVLTGVglttptvlllllflIGCGQALTMPAWQAIQPDLVPAHQIPAAAALGSMSMNGArAIGPAIA 163
Cdd:cd06179 76 sivAGTAKSVNMLIGGQAL--------------IGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGS-ALGPLIA 140
|
170 180 190
....*....|....*....|....*....|....*..
gi 2556353321 164 GALVSVSGPT--VVFGLNAVSFVGTVIVLVLWRRPPD 198
Cdd:cd06179 141 GALVEANAAGwrWIFYINAIFNALALILLFFFYHPPP 177
|
|
| |
