|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
17-387 |
7.93e-65 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 211.33 E-value: 7.93e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 17 ALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAAT 96
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 97 VDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALAC 176
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 177 VLAAVICAIGVLDPPRPPRAEAPPEHL---ANPYRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALV 253
Cdd:cd17475 161 ILAAVLFWLFYREPPAASAATESASTLlrsLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 254 TVAQVLGAGGRIAAGRWSDVI--GSRLRPIRYIAAAASVTMALLAV-TDALGSPVSVALMVIASVVTVSDNGLAFTAIAE 330
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLlSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2556358434 331 IAGPFWSGRALGTQNTSQHLATALGSPLFGALIGVV-GYPLAFAVCALFPVAAYRLVP 387
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVLAALLLL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-382 |
3.85e-37 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 138.08 E-value: 3.85e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 3 DTISTTRRWSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTV 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 83 GSALTAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAES 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 163 HGVSTALLFPALACVLAAVIcaigvldpprppraeappehlanpyrgssVLVRIHAVSVLLVIPQGFVWTFTLVWLMTDR 242
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL-----------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 243 GWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGSRLRPIrYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNG 322
Cdd:COG2271 212 GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV-LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 323 LAFTAIAEIAGPFWSGRALGTQNTSQHLATALGSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLA 350
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-382 |
5.92e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 119.22 E-value: 5.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 8 TRRWSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALT 87
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 88 AAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVST 167
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 168 ALLFPALACVLAAVICAIGVLDPPRPPRAEAPPEHLAnpYRGSSVLVRIHAVSVLLVIPQGFVWTFTLV---WLMTDRGW 244
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD--QLEALRDPRFWLLSLLYFGTFGSFIGFSSWlppYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 245 SAAAAGALVTVAQVLGAGGRIAAGRWSDVIGSrlRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLA 324
Cdd:COG2223 239 SAATAGLLAALFALLGALGRPLGGWLSDRIGG--RRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2556358434 325 FTAIAEIAGPFWSGRALGTQNTSQHLATALGSPLFGALIGVVG-YPLAFAVCALFPVAA 382
Cdd:COG2223 317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVA 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-356 |
2.40e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.80 E-value: 2.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 31 AAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLG 110
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 111 GMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAIGVLDP 190
Cdd:pfam07690 96 GLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 191 PRPPRAEAPPEHLANPYRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWL---MTDRGWSAAAAGALVTVAQVLGAGGRIAA 267
Cdd:pfam07690 176 ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLplyQEVLGLSALLAGLLLGLGGLLGAIGRLLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 268 GRWSDVIGSRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQNTS 347
Cdd:pfam07690 256 GRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTA 335
|
....*....
gi 2556358434 348 QHLATALGS 356
Cdd:pfam07690 336 GSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-382 |
4.48e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 93.79 E-value: 4.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 34 LIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMA 113
Cdd:cd17325 18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 114 AASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAIGVLDPPRP 193
Cdd:cd17325 98 SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 194 PRAEAPPEHLANPYRGSSVLVR----IHAVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVLGAGGRIAAGR 269
Cdd:cd17325 178 PNKRAVSAARLRSGLRLLLRDRrllaLFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 270 WSDVIGsRLRPIRYIAAAASVTMALLAVTDALgsPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQNTSQH 349
Cdd:cd17325 258 LSDRIG-RKPLILIGLLLSAVALLLLPLATSF--WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS 334
|
330 340 350
....*....|....*....|....*....|...
gi 2556358434 350 LATALGSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:cd17325 335 LGMVLGPLLGGFLYDAFGFATPFLAAAALLLLA 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-354 |
6.43e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.95 E-value: 6.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 4 TISTTRRWSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVG 83
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 84 SALTAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESH 163
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 164 GVSTALLFPALACVLAAVICAIGVLDPPRPPRAEAPPEHLAnpYRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMTDRG 243
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE--LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 244 WSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGsRLRPIRYIAAAASVTMALLAVTDALgsPVSVALMVIASVVTVSDNGL 323
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLAGRLADRFG-RRRLLLIGLLLLALGLLLLALAGSL--WLLLLALFLLGFGFGLLFPL 316
|
330 340 350
....*....|....*....|....*....|.
gi 2556358434 324 AFTAIAEIAGPFWSGRALGTQNTSQHLATAL 354
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-382 |
6.91e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.48 E-value: 6.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 28 INGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFL 107
Cdd:cd06174 12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 108 LLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVS--TALLFPALACVLAAVICAI 185
Cdd:cd06174 92 FLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFLIAAALALLAAILLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 186 GVLDPPRPPRAEAPPEHLANP------YRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVL 259
Cdd:cd06174 172 VVPDPPESARAKNEEASSKSVlkllkrVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 260 GAGGRIAAGRWSDVIGSRLRPIRYIAAAASVTMALLAVTDALgsPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGR 339
Cdd:cd06174 252 GALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL--LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGT 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2556358434 340 ALGTQNTSQHLATALGSPLFGALI-GVVGYPLAFAVCALFPVAA 382
Cdd:cd06174 330 AFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLA 373
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-382 |
9.15e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 87.24 E-value: 9.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 6 STTRRWSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSA 85
Cdd:COG2807 12 RRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 86 LTAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFpPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGV 165
Cdd:COG2807 92 LLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 166 STALLFPALACVLAAVICAIGVLDPPRPPRAEAPPEHLANPYRgsSVLVRIHAVSVLLvipQGFVWTFTLVWL---MTDR 242
Cdd:COG2807 171 RGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWR--SPLAWLLTLFFGL---QSLLYYAVVAWLppiLRDA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 243 GWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGSRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSdng 322
Cdd:COG2807 246 GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFP--- 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2556358434 323 LAFTAIAEIAG-PFWSGRALGTQNTSQHLATALGSPLFGALIGVVG-YPLAFAVCALFPVAA 382
Cdd:COG2807 323 LALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLM 384
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
47-382 |
2.98e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 2.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 47 AAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVV 126
Cdd:cd17489 31 AVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 127 GWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAiGVLDPPRPPRAEAPPEHLANP 206
Cdd:cd17489 111 DIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF-LVKDPPPVAAEEAEAGTRAFR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 207 YRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMtDRGWSaaAAGALVTVAQVLGAGGRIAAGRWSDvigsRLRPIRYIAA 286
Cdd:cd17489 190 RLVEKKVLPPALILFLASIAYGAISTFLPLYAA-ERGIS--NAGLFFTVYAIALLLSRPFSGKLSD----RKGPKTVIIP 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 287 AASVTMALLAvtdALGSPVSVALMVIASVVTVSDNGLAFTA----IAEIAGPFWSGRALGTQNTSQHLATALGSPLFGAL 362
Cdd:cd17489 263 GLLLLALGLL---LLSFAGSPWMLLLAAVLYGLGFGLLFPAlqalAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339
|
330 340
....*....|....*....|
gi 2556358434 363 IGVVGYPLAFAVCALFPVAA 382
Cdd:cd17489 340 AELFGYRAMFLLAAVVVLLA 359
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
27-386 |
6.87e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 69.61 E-value: 6.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 27 FINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWA-VGA 105
Cdd:cd17355 18 IRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQlYLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 106 FLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAI 185
Cdd:cd17355 98 WGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 186 GVLDPPRPPRAEAPPEHLANPYRGSSVLVRIHAVSVLLVIPQ---GFVWTF---TLVWLMTDRGWSAAAAGALVTVAQVL 259
Cdd:cd17355 178 LLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFflcGFAVVGlivHLVPYLADRGISPAAAAVALALIGLF 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 260 GAGGRIAAGRWSDVIGSRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDngLAFTAIAEIAGPFWSGR 339
Cdd:cd17355 258 NIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVP--LTAALAARYFGARSYGT 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2556358434 340 ALGTQNTSQHLATALGSPLFGALIGVVG-YPLAFAVCALFPVAAYRLV 386
Cdd:cd17355 336 LFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLV 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-382 |
4.21e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 66.81 E-value: 4.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 34 LIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMA 113
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 114 AASSNSAsGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAIGVLDPPRP 193
Cdd:cd17478 98 SAAFHPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 194 PRAEAPPEHLANPYRG-SSVLVRIHAVSVLLVIPQGFVWTFTLVWLMtDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSD 272
Cdd:cd17478 177 AKKAAAKSSARSTLKGvWRALLLLLIIVFLRSWVLSSLTTFLPFYLV-QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSD 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 273 VIGSRlrpiRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEIAGP---FWSGRALGTQNTsqh 349
Cdd:cd17478 256 RFGRR----RVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGnvgLASGLMMGLSFG--- 328
|
330 340 350
....*....|....*....|....*....|...
gi 2556358434 350 lATALGSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:cd17478 329 -LGGIGAPVLGALADAFGLESVLLILALLPLLG 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-386 |
8.47e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 66.05 E-value: 8.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 32 AFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGG 111
Cdd:cd17319 23 SVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 112 MAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAIgvldpp 191
Cdd:cd17319 103 VAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 192 rppraeappehlanpyrgssvLVRIHAVSVLLVIPQGFVWTFTLVWLMT----DRGWSAAAAGALVTVAQVLGAGGRIAA 267
Cdd:cd17319 177 ---------------------YLRQVWGLALGYFGINYALYGLLTWLPTylkqARGFSLKQVGLLAAIPFLAGAIGMILG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 268 GRWSD--VIGSRLRPIRYIAAAASVTMALLAVTDALGspVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQN 345
Cdd:cd17319 236 GRLSDrlLRGARRLVIIIGLLLAAVGLLLAYLTTSPV--VAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLIN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2556358434 346 TSQHLATALGSPLFGALIGVVGYP----LAFAVCALFPVAAYRLV 386
Cdd:cd17319 314 SGGNLGGFVAPLLIGYLVDATGSYtaafLFLAAVALLAALLVLLL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-382 |
1.09e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 65.65 E-value: 1.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 16 IALTATTCANVFINGAAF-----LIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAF 90
Cdd:COG0738 7 RRALIAIYLLFFLWGFATalwgpLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 91 AFGAATVDSLWAVGAFLLLGGMAAASSNSASGrVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESH---GVST 167
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAAN-PYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 168 ALLFPALACVLAAVICAIGVLDPPRPPRAEAPPEHLANPYRGSSVLVRIHAVSVLL-VIPQGFVWTFTLVWLMTDRGWSA 246
Cdd:COG0738 166 PYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLyVGAEGAIGDWLPLYLKDVLGLSE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 247 AAAGALVTVAQVLGAGGRIAAGRWSDVIGSRlRPIRYIAAAASVTMALLAVTDalGSPVSVALMVIASVVTVSDNGLAFT 326
Cdd:COG0738 246 ATAALGLSLFWGGMTIGRFLGGFLLKRFGPV-RLLRLSALLAAVGLLLALLAP--GPWLALIGLALVGLGLSLMFPTIFS 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2556358434 327 AIAEIAGPFwSGRALGTQNTSQHLATALGSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:COG0738 323 LALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-375 |
1.24e-11 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 65.37 E-value: 1.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 10 RWSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAA 89
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 90 FAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTAL 169
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 170 LFPALACVLAAVICAIGVLDpprppraeappehlanpyrgSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMTDR-GWSAAA 248
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRD--------------------SPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVkGYSLID 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 249 AGALVTVAQVLGAGGRIAAGRWSDVI--GSRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFT 326
Cdd:cd17312 221 AGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGA 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2556358434 327 AIAEIAGPFWSGRALGTQNTSQHLATALGSPLFGALIGVVGYPLAFAVC 375
Cdd:cd17312 301 AAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFL 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-185 |
1.48e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 65.28 E-value: 1.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 11 WSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGER--IVLTVGSALTA 88
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 89 AFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTA 168
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170
....*....|....*..
gi 2556358434 169 LLFPALACVLAAVICAI 185
Cdd:COG2271 340 FLLLAALALLAALLALL 356
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
33-272 |
3.67e-11 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 64.28 E-value: 3.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 33 FLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGM 112
Cdd:cd17343 24 FVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 113 AAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAIGVLDPPR 192
Cdd:cd17343 104 AQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 193 PPRAEAPPEHLANPYRGSSVLVRIHAVSVLL-----VIPQGFVWTF---------TLVWLMTDRGWSAAAAGALVTVAQV 258
Cdd:cd17343 184 DVGLNNIEEEESKGKKKKSPRGESTLKELLLspflwLLSLGYLVVFgvktavtdwGQLFLIQDKGQSALTGSSFMSSLEV 263
|
250
....*....|....
gi 2556358434 259 LGAGGRIAAGRWSD 272
Cdd:cd17343 264 GGFVGSIAAGYLSD 277
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-382 |
6.55e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 63.34 E-value: 6.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 34 LIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMA 113
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 114 AASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAIGVLDPPRP 193
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 194 PRAEAPPEHLANPYRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSDv 273
Cdd:cd17324 181 KPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 274 igsRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQNTSQHLATA 353
Cdd:cd17324 260 ---RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGA 336
|
330 340
....*....|....*....|....*....
gi 2556358434 354 LGSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:cd17324 337 LGAALGGLVLDHGGWAGVGWVGAALLLLA 365
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
37-382 |
5.62e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.20 E-value: 5.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 37 TLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMAAAS 116
Cdd:cd17330 24 REFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 117 SNSASGrVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICaigvldpprppra 196
Cdd:cd17330 104 VSVAQA-YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLV------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 197 eappehlanpYRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGS 276
Cdd:cd17330 170 ----------LFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 277 RLRPIRYIAAAASVTMALLAVtdalgsPVSVALMVIASVVTVSDNGLAFTA----IAEIAGPFWSGRALGTQNTSQHLAT 352
Cdd:cd17330 240 ERKLLRLGLLLAIIGLLLLPF------ASSVPLLVLAAAILAFGTGIVFPAlsalLSKSVPSKEQGKAQGIIQSLQSLAR 313
|
330 340 350
....*....|....*....|....*....|
gi 2556358434 353 ALGSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:cd17330 314 IIGPLLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
43-395 |
1.35e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.45 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 43 GLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGER------------IVLTVGSALTAAFAFGAATVDSLWAVGAFLLLG 110
Cdd:COG2211 42 GLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrpwiligaIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 111 GMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLA------ESHGVSTALLFPALACVLAAVICA 184
Cdd:COG2211 122 LAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVaafggdAALGYRLTALIFAVLGLLAFLLTF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 185 IGVLDPPRPPRAEAPPEHLANPYRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVLGAGGR 264
Cdd:COG2211 202 FGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 265 IAAGRWSDVIGsRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEIA-------GPFWS 337
Cdd:COG2211 282 PLWPRLAKRFG-KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRRE 360
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2556358434 338 GRALGTQNTSQHLATALGSPLFGALIGVVGY---------------------PLAFAVCALFPVAAYRLVPADPEPITR 395
Cdd:COG2211 361 GLYFGIFTFAIKLGQALAGALAGLLLALFGYvagaaqspsaltgirllffllPAVLLLLAALLLLFYPLTRERHAEIRA 439
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-187 |
3.97e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.50 E-value: 3.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 2 PDTISTTRRWSMLVIALTATTCANVFINGAAF-----LIPTLHTER-GLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVG 75
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFgalepFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 76 ERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALV 155
Cdd:cd17325 264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
170 180 190
....*....|....*....|....*....|..
gi 2556358434 156 IPRLAESHGVSTALLFPALACVLAAVICAIGV 187
Cdd:cd17325 344 GGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-182 |
5.26e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.11 E-value: 5.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 11 WSMLVIALtATTCANVFINGAAFLIPT-LHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRV---GERIVLTVGSAL 86
Cdd:cd17319 179 RQVWGLAL-GYFGINYALYGLLTWLPTyLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 87 TAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAE-SHGV 165
Cdd:cd17319 258 AAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSY 337
|
170
....*....|....*..
gi 2556358434 166 STALLFPALACVLAAVI 182
Cdd:cd17319 338 TAAFLFLAAVALLAALL 354
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
32-183 |
7.75e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 53.92 E-value: 7.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 32 AFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGG 111
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2556358434 112 MAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGA-LVIPRLAESHGVSTALLFPALACVLAAVIC 183
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAIIVSLIC 167
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-382 |
1.05e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.33 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 34 LIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMA 113
Cdd:cd17477 18 LLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 114 AASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLaeshGVSTALLFPALACVLAAVICAIGVLDPPRP 193
Cdd:cd17477 98 LAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV----GTAGALPFLIAAVLLLLALVPLLLTRRAAP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 194 PRAEAPPEHLANPYRGSSVLVrihAVSVLLVIPQGFVWTFTLVWLMtDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSDV 273
Cdd:cd17477 174 EIEEAESISLRRLLRIAPLAL---LGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 274 IGSRLrpiryIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAeIAGPFWSGRALGTQNTSQHLATA 353
Cdd:cd17477 250 FDRRR-----VLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALA-LAGDRLPGDELVAANAALLLLYG 323
|
330 340 350
....*....|....*....|....*....|....*.
gi 2556358434 354 LGS---PLFGAL----IGVVGYPLAFAVCALFPVAA 382
Cdd:cd17477 324 LGSvigPLLAGAlmdaFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
130-382 |
3.94e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.39 E-value: 3.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 130 PPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVS--TALLFPALACVLAAVICAIGVLDPPRPPRAEAPPeHLANPY 207
Cdd:cd17370 118 PPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKS-KKTSLK 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 208 RGSSVLVRIHAVSVLLVIpqgFVWTFTLVWL-MTDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGsrlRPIRYIAA 286
Cdd:cd17370 197 KLPKAFWLYLLAVALFAL---GNFSFAFLILrAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIG---RKKLLILG 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 287 AASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQNTSQHLATALGSPLFGALIGVV 366
Cdd:cd17370 271 YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
|
250
....*....|....*.
gi 2556358434 367 GYPLAFAVCALFPVAA 382
Cdd:cd17370 351 SPSAAFLFSAVLALIA 366
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
10-382 |
4.30e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.46 E-value: 4.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 10 RWSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAA 89
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 90 FAFGAATVDSLWAVG-AFLLLGGMAAASSNSASGRVVVGWFpPEQRGLAMGIrqtaTPLGVGIGALVIPRLAES----HG 164
Cdd:cd17353 81 GFILSAFAISLPLLFlGYGVLGGIGAGIGYITPVSTAVKWF-PDKRGLATGI----VIAGFGLGSLIFSPLIAYlintVG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 165 VSTALLFPALACVLAAVICAIGVLDPPRPPRAEAPPEHLANPYRGSSVLVRIHAvsvlLVIPQGFV--WTFTLVW----- 237
Cdd:cd17353 156 VPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREM----LRTPTFWLlwLMFFLNAtaglm 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 238 --------LMTDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGsRLRPIRYIAAAASVTMALLavtdaLGSPVSVAL 309
Cdd:cd17353 232 ligqakpiGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIG-RKNTLSIAFLIQGVAMFLL-----PFIGSVAVL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2556358434 310 MVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQN----TSQHLATALGSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:cd17353 306 FVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYgllyTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVA 382
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-382 |
1.30e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 38 LHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMAAASS 117
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 118 NSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVstaLLFPALACVLaaVICAIGVLDPPRPPRAE 197
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR---LLFLAAAVLF--LLAALVLLFLLPETRPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 198 APPEHLANPYRGSSVLVRIHAVSVLLVIpqGFVWTFTLVWLMT--------DRGWSAAAAGALVTVAQVLGAGGRIAAGR 269
Cdd:cd17329 181 RRAAEKTEILRGYKIVLRDRAFLLFLLA--SFLISLIYFQLEStlpvyvveILGLGESLLGLLLALNALLIVLLQFPVAR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 270 WSdvigSRLRPIRYIAAAAS-VTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQNTSQ 348
Cdd:cd17329 259 LV----ERFRLRKILMIGILlFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAW 334
|
330 340 350
....*....|....*....|....*....|....
gi 2556358434 349 HLATALGSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:cd17329 335 GLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIA 368
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-382 |
2.80e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.82 E-value: 2.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 218 AVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGSRlRPIRYIAAAASVTMALLAV 297
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRR-RVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 298 TDALgsPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQNTSQHLATALGSPLFGALIGVVGYPLAFAVCAL 377
Cdd:COG2814 95 APSL--WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172
|
....*
gi 2556358434 378 FPVAA 382
Cdd:COG2814 173 LALLA 177
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
11-185 |
2.91e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.75 E-value: 2.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 11 WSMLVIALTATTCANVFINGAAFLIPTLH-TERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAA 89
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLqTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 90 FAFG--AATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVST 167
Cdd:cd17316 256 LALPlfYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*...
gi 2556358434 168 ALLFPALACVLAAVICAI 185
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-185 |
8.79e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 8.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 13 MLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWG-WLVDRVGERIVLTVGSALTAAFA 91
Cdd:cd17474 200 LLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 92 FGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLF 171
Cdd:cd17474 280 LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV 359
|
170
....*....|....
gi 2556358434 172 PALACVLAAVICAI 185
Cdd:cd17474 360 GAAIALAAAVLLAL 373
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
43-331 |
9.40e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 47.30 E-value: 9.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 43 GLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLT----VGSALTAAFAFGAATVDSLWAVGAFLLLGGMAAASSN 118
Cdd:TIGR00886 33 GLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTAlsllLLAIPCLWAGLAVQSYSVLLLIRLFIGIAGGSFASCM 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 119 SASGRvvvgWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAES----HGVSTALLF-PALACVLAAVICAIGVLdpprp 193
Cdd:TIGR00886 113 PWISF----FFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSlifgGGQPAHLAWgWAFVIVPAGILLLPALL----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 194 praeaPPEHLANPYRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMT-----------------DRGWSAAAAGALVTVA 256
Cdd:TIGR00886 184 -----IFFVGADTPPGKPATGKLSFKEALKVFGNRHTWILALLYSVTfgsflgvssifamlfkdQFGLSKVQAGAYASLG 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2556358434 257 QVLGAGGRIAAGRWSDVIGS-RLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEI 331
Cdd:TIGR00886 259 GFLGSLARPAGGAISDRLGGaRKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAGAGNGSTFALVPHI 334
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-293 |
1.22e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.73 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 2 PDTISTTRRWSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLT 81
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 82 VGSALTAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAE 161
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 162 SHGVSTALLFPALACVLAAVICAIGVLDPPRPPRAEAPPEHLANPYRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMTD 241
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2556358434 242 RGWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGSRLRPIRYIAAAASVTMA 293
Cdd:COG0477 244 ALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
46-382 |
2.45e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 46 LAAAGLLSAMPSFGLVVTLIAwGWLVDRVGERIVLTV-----GSALTAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSA 120
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFA-GVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 121 SGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAIGVLDPPRPPRAEAPP 200
Cdd:cd06173 113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 201 EHLA-----NPYRGSSVLVRIHAVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVaqvlGAGGRIAAGRWSDVIG 275
Cdd:cd06173 193 LLRDlreglRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA----FGVGALLGALLLGRLS 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 276 SRLRPIRYIAAAASVTMALLAVTDALGS-PVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQNTSQHLATAL 354
Cdd:cd06173 269 KRRRRGRLLLIGALLLGLALLVLGLSPSlWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348
|
330 340
....*....|....*....|....*...
gi 2556358434 355 GSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:cd06173 349 GALLAGLLADALGLSAVFLLAGALLLLA 376
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
53-382 |
4.08e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 4.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 53 SAMPSFGLVVTLIAwGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAV-GAFLLLGGMAAASSNSASGRVVVGWFPp 131
Cdd:cd17352 45 SLLLGVSLFSGPLS-SALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYGVLGGLGLGLIYSPAIVIVGQYFE- 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 132 EQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAIGVLdpprppraeappehLANPyrgss 211
Cdd:cd17352 123 KKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLRL--------------LKDP----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 212 vLVRIHAVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGSRlRPIRYIAAAASVT 291
Cdd:cd17352 184 -TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIG-RLYLYIFTLLILG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 292 MALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQNTSQHLATALGSPLFGALIGVVG-YPL 370
Cdd:cd17352 262 LSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGdYDA 341
|
330
....*....|..
gi 2556358434 371 AFAVCALFPVAA 382
Cdd:cd17352 342 AFYFCGACLLLS 353
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-382 |
4.30e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.29 E-value: 4.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 32 AFLIPTLHTER--GLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLL 109
Cdd:cd17316 19 GFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 110 GGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALV----IPRLAESHGVSTALLFPALACVLAAVICAI 185
Cdd:cd17316 99 QGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVasllIPLLSGDWGWRILFLIGALPALLALLLRRR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 186 gvldpprppraeappehlanpyrgssvLVRIHAVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVLGAGGRI 265
Cdd:cd17316 179 ---------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 266 AAGRWSDVIGsRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQN 345
Cdd:cd17316 232 IAGLLSDRIG-RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSY 310
|
330 340 350
....*....|....*....|....*....|....*..
gi 2556358434 346 TSQHLATALGSPLFGALIGVVGYPLAFAVCALFPVAA 382
Cdd:cd17316 311 NLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
31-313 |
4.49e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 45.27 E-value: 4.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 31 AAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLG 110
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 111 GMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVICAIGVLdp 190
Cdd:cd17365 98 GLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTLL-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 191 prppraeappehlanpyrgssvlvrIHAVSVLLVipqgFVWTFTLVW---LMTDRGWSAAAAGALVTVAQVLGAGGRIAA 267
Cdd:cd17365 176 -------------------------LWVTFFMGL----LLVYLLNSWlpkLMVEAGYSLSQALTITLLLNIGGVIGSLLL 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2556358434 268 GRWSDvigsRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIA 313
Cdd:cd17365 227 GWLAD----RFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVF 268
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
26-364 |
5.07e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 5.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 26 VFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGA 105
Cdd:cd17321 10 LDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 106 FLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVicai 185
Cdd:cd17321 90 ARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL---- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 186 gvldpprppraeappehLANPYRGSSVlvrihaVSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVLGAGGRI 265
Cdd:cd17321 166 -----------------LARTFSGAVL------AAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 266 AAGRWSDVIGSRLrPIRYIAAAASVTMALLAVTDALGSPVSVAL-MVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQ 344
Cdd:cd17321 223 LAGRLADRFGPRL-VLVAGLLLTAVGLLLLALLGADSSVWLLLPgLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGIL 301
|
330 340
....*....|....*....|
gi 2556358434 345 NTSQHLATALGSPLFGALIG 364
Cdd:cd17321 302 NTARQLGGALGVALLGALLT 321
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
10-378 |
5.19e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 45.10 E-value: 5.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 10 RWSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAA 89
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 90 FAFGAATVDSLW-AVGAFLLLGGMAAASSNSASGRVVVGWFPpEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTA 168
Cdd:cd17314 81 GYTYLSYVFNSFpLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 169 LLFpaLACVLAAVICAIGVLDPPRPPRAEAPPEHLANPYRGSSVLVRIHAVSVL-LVIPQGFVWTFTLVWLMTDRGWSAA 247
Cdd:cd17314 160 YTI--LGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILfIAIFLVLIGGFLFIANMASLVRSLQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 248 AAGA-----LVTVAQVLGAGGRIAAGRWSDVIGSRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNG 322
Cdd:cd17314 238 LDAPsfvtkLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFT 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2556358434 323 LAFTAIAEIAGPFWSGRALGTQNTSQHLATALGSPLFGALIGVV-GYPLAFAVCALF 378
Cdd:cd17314 318 VYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTpSYISAVYIYAVI 374
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
32-277 |
6.79e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.60 E-value: 6.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 32 AFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGG 111
Cdd:cd17371 19 GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 112 MAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGA----LVIPRLAESHGVSTALLFPALACVLAAVIcAIGV 187
Cdd:cd17371 99 LGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATllaaLLFPLLPPEIAWRVLFLLGALPALLVLFI-RRFV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 188 LDPPRPPRAEAPPEHLANPYRGSSV----LVRIHAVSVLLVIPQGFVWTFTLVW----LMTDRGWSAAAAGALVTVAQVL 259
Cdd:cd17371 178 KEPPQWQAARAARRHFADRPSLRELfsppLLRTTLLASLLATGALGGYYGITTWlpsyLTGERGLSFEGSAGYLVVTILG 257
|
250
....*....|....*...
gi 2556358434 260 GAGGRIAAGRWSDVIGSR 277
Cdd:cd17371 258 GFLGYLAGGFLADRIGRR 275
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-182 |
7.78e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 44.65 E-value: 7.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 3 DTISTTRRWSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTV 82
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 83 GSALTAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAES 162
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV 167
|
170 180
....*....|....*....|
gi 2556358434 163 HGVSTALLFPALACVLAAVI 182
Cdd:TIGR00895 168 FGWRSLFYVGGIAPLLLLLL 187
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-182 |
8.27e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 8.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 9 RRWSMLVIALTATTCANVFINGAAFLIPTL-HTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALT 87
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLaKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 88 AAFAFGAATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVST 167
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*
gi 2556358434 168 ALLFPALACVLAAVI 182
Cdd:cd06173 365 VFLLAGALLLLAALL 379
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
219-382 |
1.71e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 219 VSVLLVIPQGFVWTFTLVWLMTDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIGSRlrpIRYIAAAASVTMALLAVT 298
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR---RVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 299 DALGSPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGTQNTSQHLATALGSPLFGALIGVVGYPLAFAVCALF 378
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
....
gi 2556358434 379 PVAA 382
Cdd:pfam07690 161 SLLA 164
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
31-325 |
2.25e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.01 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 31 AAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDS----LWAVGAF 106
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSsywgLLVLGFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 107 LLLGGMAAASSNSASGRvvvgWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESH-------GVSTALLFPALACVLA 179
Cdd:cd17341 98 LGFAGANFASGQPWASF----WFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIvfdggfvGWRNAFFVPGILLAIA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 180 AVICAIGVLDPPRPPRAEAPPEHlanPYRGSSVLVRIHAVSVLLVIPQGFVWTFTLV---WLMTDRGWSAAAAGALVTVA 256
Cdd:cd17341 174 AVLVLLFGDDLPTGKASALEFLK---VQLAVLKNYRTWILSLLYGVTFGSFVGFSNVlptYFKTRFGLPLVTAGILAALF 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2556358434 257 QVLGAGGRIAAGRWSDVIG--SRLRPIRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAF 325
Cdd:cd17341 251 PLAGALARPAGGWLSDRFGgrRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVF 321
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
32-183 |
2.28e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 43.00 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 32 AFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVG----SALTAAFAFGAATVDSLWAVGAFL 107
Cdd:cd17345 23 SLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGlilsAIINILIGFVPSATSSVGLMFILL 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2556358434 108 LLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAE---SHGVSTALLFPALACVLAAVIC 183
Cdd:cd17345 103 FLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAifgDGWWRGAFIFPAIIAIIVAVIV 181
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
61-378 |
4.45e-04 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 42.00 E-value: 4.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 61 VVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLG----GMAAASSNSASGRVVVGWFPPEQRGL 136
Cdd:cd17334 53 VPGVFAFCWLLDKVGLRIGVLIGAALNALGSVLKCIPLGQQPKFALLVLGqvlnALAQVLVLSLPPLIAAVWFPPKERTT 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 137 AMGIRQTATPLGVGIGALVIPRLAEShGVSTALLFPALACVLAAVICAIGVLDPP-----------RPPRAEAPPEHLAN 205
Cdd:cd17334 133 ATAIASLANFLGCAIGFLLPPVVVPP-PKGTKKEFGAVFYGEFGFACLLLALVLAlfppkpkyppsAASARQQNSEHVIL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 206 PYRGSSVLVRIHAVSVLLV----IPQGFVWTFTLVW--LMTDRGWSAAAAGALVTVAQVLGAGGRIAAGRWSDVIgSRLR 279
Cdd:cd17334 212 ELQKSISELLRNEPFVLLAvafsIMMGVFAGFSSVLaqILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRT-RMFK 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 280 PIRYIA---AAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNG---LAFTAIAEIAGPFWSGRALGTQNTSQHLATA 353
Cdd:cd17334 291 LIGLIIlalGTVVCTFFMLLVDRYGLPYVTLAFYLLCGLLGFFQNSmvpIMFELAVELTYPVPESVSTGVLTALANLFSF 370
|
330 340
....*....|....*....|....*....
gi 2556358434 354 LGSPLFGALIG----VVGYPLAFAVCALF 378
Cdd:cd17334 371 LLMLVFSELLGptptESKYLLWFILCTVG 399
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
35-182 |
6.15e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 6.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 35 IPTLHTERGLDlaAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMAA 114
Cdd:cd17489 217 LPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF 294
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2556358434 115 ASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALLFPALACVLAAVI 182
Cdd:cd17489 295 GLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
11-184 |
1.36e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 11 WSMLVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAF 90
Cdd:cd17478 194 WRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPF 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 91 AFGAATVDSLWAVGAFLLLGGMAAASSNSASgrVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHGVSTALL 170
Cdd:cd17478 274 LLLFLLTPGIWSYILLVLAGFLLFASFPVTV--VLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLL 351
|
170
....*....|....
gi 2556358434 171 FPALACVLAAVICA 184
Cdd:cd17478 352 ILALLPLLGALLAF 365
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
129-378 |
1.62e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 40.29 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 129 FPPEQRGLAMGIRQTATPLGVGIGALVIprLAESHGVSTALLFPALACVLAavICAIGVLDPPRPPRAEAPPEHLANPYR 208
Cdd:cd17485 121 LTPEERGLGNAAQVVGYKLGSLLGGGGL--LWLYDLIGWQSLLLSLAALYL--LLLLPVLFLRELELPQQPPASERGAAL 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 209 GSSVLVRIH------AVSVLLVIPQGFVWTFTLVWLM-TDRGWSAAAAGALVTV-AQVLGAGGRIAAGRWSDVIGsRLRP 280
Cdd:cd17485 197 KASLRAFLRrpgtrwLLLFLLLYKLGEQGALAMLPPFlVDRGFSLSQIGLLSGVgGSLVSIAGSLLGGYLLKRRG-RRRL 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 281 IRYIAAAASVTMALLAVTDALGSPVSVALMVIASVVTVSDNGLAFTAIAEIAGPFWSGRALGT----QNTSQHLATALGS 356
Cdd:cd17485 276 LLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTdytlLATVEVLGKLLFG 355
|
250 260
....*....|....*....|..
gi 2556358434 357 PLFGALIGVVGYPLAFAVCALF 378
Cdd:cd17485 356 SLAGFLADHLGYAAAFLLFAIL 377
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
41-187 |
1.70e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.30 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 41 ERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMAAASSNSA 120
Cdd:cd17328 28 DFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPI 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2556358434 121 SGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGALVIPRLAESH-GVSTALLFPALACVLAAVICAIGV 187
Cdd:cd17328 108 APTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFV 175
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
34-164 |
2.17e-03 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 39.70 E-value: 2.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 34 LIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFGAATVDSLWAVGAFLLLGGMA 113
Cdd:cd17410 21 LLNEIRAATGLSFQVASLLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLWSGTGPTLIASALLGGLG 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2556358434 114 AASSNSASGRVVVGWFpPEQRGLAMGIRQTATPLGVGIGALVIPRLAESHG 164
Cdd:cd17410 101 IAIIQALVPGLIKRRF-PARVPLAMGLYSASLMAGGGLAASLSPRLAQHSA 150
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-153 |
4.71e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556358434 14 LVIALTATTCANVFINGAAFLIPTLHTERGLDLAAAGLLSAMPSFGLVVTLIAWGWLVDRVGERIVLTVGSALTAAFAFG 93
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2556358434 94 ---AATVDSLWAVGAFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGIGA 153
Cdd:pfam07690 282 lllLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| |
