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Conserved domains on  [gi|2564950813|ref|WP_306148843|]
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MULTISPECIES: class I SAM-dependent methyltransferase [Bacillus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 72-218 4.09e-40

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 137.43  E-value: 4.09e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  72 FSKNAEMYRDEKvfaegedlgLMIKTAECRAEHRVLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVeN 151
Cdd:COG2226     1 FDRVAARYDGRE---------ALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-N 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2564950813 152 VRFQQGTAESLPFPDDSFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFV 218
Cdd:COG2226    71 VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 72-218 4.09e-40

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 137.43  E-value: 4.09e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  72 FSKNAEMYRDEKvfaegedlgLMIKTAECRAEHRVLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVeN 151
Cdd:COG2226     1 FDRVAARYDGRE---------ALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-N 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2564950813 152 VRFQQGTAESLPFPDDSFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFV 218
Cdd:COG2226    71 VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 107-203 4.20e-31

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 112.37  E-value: 4.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 107 LDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVEnvrFQQGTAESLPFPDDSFDIITCRYAAHHFSDVRK 186
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLT---FVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*..
gi 2564950813 187 AVREVARVLKQDGRFLL 203
Cdd:pfam08241  78 ALREIARVLKPGGILII 94
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 95-217 2.11e-23

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 95.79  E-value: 2.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  95 IKTAECRAEHRVLDIGAGAGHTALAFS---PYVQECIGVDATKEMVEVAssfaQEKGV--ENVRFQQGTAESLPFPDDSF 169
Cdd:TIGR01934  32 VKLIGVFKGQKVLDVACGTGDLAIELAksaPDRGKVTGVDFSSEMLEVA----KKKSElpLNIEFIQADAEALPFEDNSF 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2564950813 170 DIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEF 217
Cdd:TIGR01934 108 DAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANALLKKF 155
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 94-217 1.55e-22

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 94.06  E-value: 1.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  94 MIKTAECRAEHRVLDIGAGAGHTALAFSPYVQ---ECIGVDATKEMVEVASS-FAQEKGVENVRFQQGTAESLPFPDDSF 169
Cdd:PRK00216   43 TIKWLGVRPGDKVLDLACGTGDLAIALAKAVGktgEVVGLDFSEGMLAVGREkLRDLGLSGNVEFVQGDAEALPFPDNSF 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2564950813 170 DIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEF 217
Cdd:PRK00216  123 DAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLKKA 170
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 105-208 2.16e-18

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 79.01  E-value: 2.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAF-SPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPF-PDDSFDIITCRYAAHHF- 181
Cdd:cd02440     1 RVLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLv 80

                          90       100
                  ....*....|....*....|....*..
gi 2564950813 182 SDVRKAVREVARVLKQDGRFLLVDHYA 208
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLTLVLA 107
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
105-247 1.83e-04

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 42.02  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  105 RVLDIGAGAGH--TALAFSPYVQECIGVDATKEMVEVASSFAQEKGVEN-VRFQQGTAESLPFPdDSFDIITCRYAAHHF 181
Cdd:smart00828   2 RVLDFGCGYGSdlIDLAERHPHLQLHGYTISPEQAEVGRERIRALGLQGrIRIFYRDSAKDPFP-DTYDLVFGFEVIHHI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2564950813  182 SDVRKAVREVARVLKQDGRFLLVDHYA-PEDPVLDEFVNHLNrlrdpshvreSSLSEWQAMFSANQL 247
Cdd:smart00828  81 KDKMDLFSNISRHLKDGGHLVLADFIAnLLSAIEHEETTSYL----------VTREEWAELLARNNL 137
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 72-218 4.09e-40

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 137.43  E-value: 4.09e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  72 FSKNAEMYRDEKvfaegedlgLMIKTAECRAEHRVLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVeN 151
Cdd:COG2226     1 FDRVAARYDGRE---------ALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-N 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2564950813 152 VRFQQGTAESLPFPDDSFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFV 218
Cdd:COG2226    71 VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 107-203 4.20e-31

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 112.37  E-value: 4.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 107 LDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVEnvrFQQGTAESLPFPDDSFDIITCRYAAHHFSDVRK 186
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLT---FVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*..
gi 2564950813 187 AVREVARVLKQDGRFLL 203
Cdd:pfam08241  78 ALREIARVLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 106-199 2.00e-30

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 110.73  E-value: 2.00e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 106 VLDIGAGAGHTALAFSPYVQ-ECIGVDATKEMVEVASSFAQEKGVeNVRFQQGTAESLPFPDDSFDIITCRYAAHHFS-- 182
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGaRVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPdp 79

                          90
                  ....*....|....*..
gi 2564950813 183 DVRKAVREVARVLKQDG 199
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 105-205 1.64e-26

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 101.25  E-value: 1.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEkgvENVRFQQGTAESLPFPDDSFDIITCRYAAHHFSDV 184
Cdd:COG2227    27 RVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAE---LNVDFVQGDLEDLPLEDGSFDLVICSEVLEHLPDP 103

                          90       100
                  ....*....|....*....|.
gi 2564950813 185 RKAVREVARVLKQDGRFLLVD 205
Cdd:COG2227   104 AALLRELARLLKPGGLLLLST 124
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 95-217 2.11e-23

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 95.79  E-value: 2.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  95 IKTAECRAEHRVLDIGAGAGHTALAFS---PYVQECIGVDATKEMVEVAssfaQEKGV--ENVRFQQGTAESLPFPDDSF 169
Cdd:TIGR01934  32 VKLIGVFKGQKVLDVACGTGDLAIELAksaPDRGKVTGVDFSSEMLEVA----KKKSElpLNIEFIQADAEALPFEDNSF 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2564950813 170 DIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEF 217
Cdd:TIGR01934 108 DAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANALLKKF 155
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 94-217 1.55e-22

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 94.06  E-value: 1.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  94 MIKTAECRAEHRVLDIGAGAGHTALAFSPYVQ---ECIGVDATKEMVEVASS-FAQEKGVENVRFQQGTAESLPFPDDSF 169
Cdd:PRK00216   43 TIKWLGVRPGDKVLDLACGTGDLAIALAKAVGktgEVVGLDFSEGMLAVGREkLRDLGLSGNVEFVQGDAEALPFPDNSF 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2564950813 170 DIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEF 217
Cdd:PRK00216  123 DAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLKKA 170
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 105-206 6.59e-22

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 89.78  E-value: 6.59e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAFSPYVQ---ECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLP--FPDDSFDIITCRYAAH 179
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELGpnaEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPelLEDDKFDVVISNCVLN 85

                          90       100
                  ....*....|....*....|....*..
gi 2564950813 180 HFSDVRKAVREVARVLKQDGRFLLVDH 206
Cdd:pfam13847  86 HIPDPDKVLQEILRVLKPGGRLIISDP 112
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 105-206 9.69e-21

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 88.05  E-value: 9.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAF-SPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGT-AESLPFPDDSFDIITCRYAAHHFS 182
Cdd:COG0500    29 RVLDLGCGTGRNLLALaARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADlAELDPLPAESFDLVVAFGVLHHLP 108

                          90       100
                  ....*....|....*....|....*.
gi 2564950813 183 DVR--KAVREVARVLKQDGRFLLVDH 206
Cdd:COG0500   109 PEEreALLRELARALKPGGVLLLSAS 134
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
96-215 1.47e-20

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 88.27  E-value: 1.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  96 KTAECRAEHR---VLDIGAGAGHTALAFSPYVQ---ECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDDSF 169
Cdd:pfam01209  33 FTMKCMGVKRgnkFLDVAGGTGDWTFGLSDSAGssgKVVGLDINENMLKEGEKKAKEEGKYNIEFLQGNAEELPFEDDSF 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2564950813 170 DIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLD 215
Cdd:pfam01209 113 DIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEFSKPENPLLS 158
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
94-247 1.80e-20

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 86.98  E-value: 1.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  94 MIKTAECRAEHRVLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVassfAQEKGVEnVRFQQGTAESLPFPDDSFDIIT 173
Cdd:COG4976    38 LLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAK----AREKGVY-DRLLVADLADLAEPDGRFDLIV 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2564950813 174 CRYAAHHFSDVRKAVREVARVLKQDGRFLLVdhyapedpvldefVNHLnrlrDPSHVRESSLSEWQAMFSANQL 247
Cdd:COG4976   113 AADVLTYLGDLAAVFAGVARALKPGGLFIFS-------------VEDA----DGSGRYAHSLDYVRDLLAAAGF 169
PRK08317 PRK08317
hypothetical protein; Provisional
 105-205 7.82e-20

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 86.53  E-value: 7.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAFSPYVQ---ECIGVDATKEMVEVASSFAQEKGVeNVRFQQGTAESLPFPDDSFDIITCRYAAHHF 181
Cdd:PRK08317   22 RVLDVGCGPGNDARELARRVGpegRVVGIDRSEAMLALAKERAAGLGP-NVEFVRGDADGLPFPDGSFDAVRSDRVLQHL 100

                          90       100
                  ....*....|....*....|....
gi 2564950813 182 SDVRKAVREVARVLKQDGRFLLVD 205
Cdd:PRK08317  101 EDPARALAEIARVLRPGGRVVVLD 124
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 105-208 2.16e-18

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 79.01  E-value: 2.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAF-SPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPF-PDDSFDIITCRYAAHHF- 181
Cdd:cd02440     1 RVLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLv 80

                          90       100
                  ....*....|....*....|....*..
gi 2564950813 182 SDVRKAVREVARVLKQDGRFLLVDHYA 208
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLTLVLA 107
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
105-205 6.57e-17

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 74.86  E-value: 6.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAFSPYVQEC--IGVDATKEMVEVAssfaqEKGVENVRFQQGTAESLPfPDDSFDIITCRYAAHHFS 182
Cdd:COG4106     4 RVLDLGCGTGRLTALLAERFPGArvTGVDLSPEMLARA-----RARLPNVRFVVADLRDLD-PPEPFDLVVSNAALHWLP 77

                          90       100
                  ....*....|....*....|...
gi 2564950813 183 DVRKAVREVARVLKQDGRFLLVD 205
Cdd:COG4106    78 DHAALLARLAAALAPGGVLAVQV 100
arsM PRK11873
arsenite methyltransferase;
86-205 5.19e-16

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 76.53  E-value: 5.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  86 AEGEDLGL----MIKTAECRAEHRVLDIGAGAGHTALAFSPYVQE---CIGVDATKEMVEVASSFAQEKGVENVRFQQGT 158
Cdd:PRK11873   57 PEGANLGLgcgnPTALAELKPGETVLDLGSGGGFDCFLAARRVGPtgkVIGVDMTPEMLAKARANARKAGYTNVEFRLGE 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2564950813 159 AESLPFPDDSFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVD 205
Cdd:PRK11873  137 IEALPVADNSVDVIISNCVINLSPDKERVFKEAFRVLKPGGRFAISD 183
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 93-205 5.40e-16

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 73.81  E-value: 5.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  93 LMIKTAECRAEHRVLDIGAGAGHTALAFSPYVQ-ECIGVDATKEMVEVASSFAQEKGVEN-VRFQQGTAESLPfPDDSFD 170
Cdd:COG2230    42 LILRKLGLKPGMRVLDIGCGWGGLALYLARRYGvRVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDLP-ADGQFD 120

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2564950813 171 IITCRYAAHHFSD--VRKAVREVARVLKQDGRFLLVD 205
Cdd:COG2230   121 AIVSIGMFEHVGPenYPAYFAKVARLLKPGGRLLLHT 157
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 107-201 5.01e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 67.01  E-value: 5.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 107 LDIGAGAGHTALAFSPYVQEC--IGVDATKEMVEVASS-FAQEKGVENVRFQQGTAESLPFPDDSFDIITCRYAAHHFSD 183
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLeyTGLDISPAALEAARErLAALGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*...
gi 2564950813 184 VRKAVREVARVLKQDGRF 201
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 98-248 1.65e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 67.07  E-value: 1.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  98 AECRAEHRVLDIGAGAGHTALAFSPYVQECIGVDAtkemvevaSSFAQEKGVENVRFQQGTAESLPFPDDSFDIITCRYA 177
Cdd:pfam13489  18 PKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDP--------SPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREV 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2564950813 178 AHHFSDVRKAVREVARVLKQDGRFLLVDHyAPEDPVLDEFvnHLNRLRDPSHvresslsEWQAMFSANQLA 248
Cdd:pfam13489  90 LEHVPDPPALLRQIAALLKPGGLLLLSTP-LASDEADRLL--LEWPYLRPRN-------GHISLFSARSLK 150
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 105-244 1.72e-13

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 68.85  E-value: 1.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHT--ALAFSPYVQECIGVDATKEMVEvassFAQEKGVENVRFQQGTAESLPFPDDSFDIITCRYAAHHFS 182
Cdd:TIGR02072  37 SVLDIGCGTGYLtrALLKRFPQAEFIALDISAGMLA----QAKTKLSENVQFICGDAEKLPLEDSSFDLIVSNLALQWCD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2564950813 183 DVRKAVREVARVLKQDGRFL---LVDHYAPEdpVLDEFVNHLNRLRdpshvresSLSEWQAMFSA 244
Cdd:TIGR02072 113 DLSQALSELARVLKPGGLLAfstFGPGTLHE--LRQSFGQHGLRYL--------SLDELKALLKN 167
PLN02244 PLN02244
tocopherol O-methyltransferase
 105-204 6.53e-13

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 68.23  E-value: 6.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTA--LAfSPYVQECIGVDATKEMVEVASSFAQEKGVEN-VRFQQGTAESLPFPDDSFDIITCRYAAHHF 181
Cdd:PLN02244  121 RIVDVGCGIGGSSryLA-RKYGANVKGITLSPVQAARANALAAAQGLSDkVSFQVADALNQPFEDGQFDLVWSMESGEHM 199

                          90       100
                  ....*....|....*....|...
gi 2564950813 182 SDVRKAVREVARVLKQDGRFLLV 204
Cdd:PLN02244  200 PDKRKFVQELARVAAPGGRIIIV 222
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 105-205 1.90e-10

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 60.29  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAFSPYVQ---ECIGVDATKEMVEVASSFAQEKG---VENVRFQQGTAESLPFPDDSFDIITCRYAA 178
Cdd:PLN02233   76 RVLDLCCGSGDLAFLLSEKVGsdgKVMGLDFSSEQLAVAASRQELKAkscYKNIEWIEGDATDLPFDDCYFDAITMGYGL 155

                          90       100
                  ....*....|....*....|....*..
gi 2564950813 179 HHFSDVRKAVREVARVLKQDGRFLLVD 205
Cdd:PLN02233  156 RNVVDRLKAMQEMYRVLKPGSRVSILD 182
PRK05785 PRK05785
hypothetical protein; Provisional
 105-194 4.71e-10

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 58.55  E-value: 4.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAFSP-YVQECIGVDATKEMVEVASsfaqekgVENVRFQqGTAESLPFPDDSFDIITCRYAAHHFSD 183
Cdd:PRK05785   54 KVLDVAAGKGELSYHFKKvFKYYVVALDYAENMLKMNL-------VADDKVV-GSFEALPFRDKSFDVVMSSFALHASDN 125

                          90
                  ....*....|.
gi 2564950813 184 VRKAVREVARV 194
Cdd:PRK05785  126 IEKVIAEFTRV 136
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 84-204 2.83e-09

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 55.97  E-value: 2.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  84 VFAEGE-DLG--LMIKTAECRAEHRVLDIGAGAG---HTALAFSPyVQECIGVDATKEMVEVASSFAQEKGVENVRFQQG 157
Cdd:COG2813    28 VFSRDRlDIGtrLLLEHLPEPLGGRVLDLGCGYGvigLALAKRNP-EARVTLVDVNARAVELARANAAANGLENVEVLWS 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2564950813 158 TAESlPFPDDSFDIITC-----------RYAAHHFsdvrkaVREVARVLKQDGRFLLV 204
Cdd:COG2813   107 DGLS-GVPDGSFDLILSnppfhagravdKEVAHAL------IADAARHLRPGGELWLV 157
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 93-237 4.57e-09

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 54.95  E-value: 4.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  93 LMIKTAECRAEHRVLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDDSFD-I 171
Cdd:COG1041    17 ALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPLADESVDaI 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2564950813 172 IT-------CRYAAHHFSD-VRKAVREVARVLKQDGRFLLVdhyAPEDPVLDEFVNHLNRLRDPSHVRESSLSE 237
Cdd:COG1041    97 VTdppygrsSKISGEELLElYEKALEEAARVLKPGGRVVIV---TPRDIDELLEEAGFKVLERHEQRVHKSLTR 167
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 84-204 2.18e-08

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 52.98  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  84 VFAEGE-DLG--LMIKTAECRAEHRVLDIGAGAGH---TALAFSPyVQECIGVDATKEMVEVASSFAQEKGVENVRFQQG 157
Cdd:pfam05175  10 VFSHGRlDIGsrLLLEHLPKDLSGKVLDLGCGAGVlgaALAKESP-DAELTMVDINARALESARENLAANGLENGEVVAS 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2564950813 158 TAESlPFPDDSFDIITCR---YAAHHFSD--VRKAVREVARVLKQDGRFLLV 204
Cdd:pfam05175  89 DVYS-GVEDGKFDLIISNppfHAGLATTYnvAQRFIADAKRHLRPGGELWIV 139
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 98-204 7.33e-08

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 52.45  E-value: 7.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  98 AECRAEHRVLDIGAGAGHTALAFSPYVQEC--IGVDATKEMVEVAS-SFAQEKGVENVRFQQGTAESLP--FPDDSFDII 172
Cdd:COG4123    33 APVKKGGRVLDLGTGTGVIALMLAQRSPGAriTGVEIQPEAAELARrNVALNGLEDRITVIHGDLKEFAaeLPPGSFDLV 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2564950813 173 TC-----------------RYAAHH-----FSDVRKAvreVARVLKQDGRFLLV 204
Cdd:COG4123   113 VSnppyfkagsgrkspdeaRAIARHedaltLEDLIRA---AARLLKPGGRFALI 163
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
162-204 3.09e-07

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 49.48  E-value: 3.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2564950813 162 LPFPDDSFDIItcrYAAH---HFS--DVRKAVREVARVLKQDGRFLLV 204
Cdd:COG4627    40 LPFPDNSVDAI---YSSHvleHLDyeEAPLALKECYRVLKPGGILRIV 84
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 105-204 1.28e-06

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 49.51  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAFSPYV--QECIGVDATKEMVEVASsfaQEKGVENVRFQQGTAESLPFPDDSFDiitcRYAA---- 178
Cdd:PLN02490  116 KVVDVGGGTGFTTLGIVKHVdaKNVTILDQSPHQLAKAK---QKEPLKECKIIEGDAEDLPFPTDYAD----RYVSagsi 188

                          90       100
                  ....*....|....*....|....*.
gi 2564950813 179 HHFSDVRKAVREVARVLKQDGRFLLV 204
Cdd:PLN02490  189 EYWPDPQRGIKEAYRVLKIGGKACLI 214
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 105-203 2.76e-06

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 47.45  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGH----TALAFsPYVQeCIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPfPDDSFDIITCRyAahh 180
Cdd:COG0357    70 RVLDVGSGAGFpgipLAIAR-PDLQ-VTLVDSLGKKIAFLREVVRELGLKNVTVVHGRAEELA-PREKFDVVTAR-A--- 142

                          90       100
                  ....*....|....*....|...
gi 2564950813 181 FSDVRKAVREVARVLKQDGRFLL 203
Cdd:COG0357   143 VAPLPDLLELALPLLKPGGRLLA 165
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 79-223 3.94e-06

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 47.27  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  79 YRDEKV----FAEGEDL---GLMIKTA------ECRAEHRVLDIGAGAGHTALAFS-PYVQECIGVDATKEMVEVASSFA 144
Cdd:PTZ00098   16 YSDEGIkayeFIFGEDYissGGIEATTkilsdiELNENSKVLDIGSGLGGGCKYINeKYGAHVHGVDICEKMVNIAKLRN 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 145 QEKGveNVRFQQGTAESLPFPDDSFDIITCRYAAHHFS--DVRKAVREVARVLKQDGRFLLVDHYAPEDPVLD-EFVNHL 221
Cdd:PTZ00098   96 SDKN--KIEFEANDILKKDFPENTFDMIYSRDAILHLSyaDKKKLFEKCYKWLKPNGILLITDYCADKIENWDeEFKAYI 173


                  ..
gi 2564950813 222 NR 223
Cdd:PTZ00098  174 KK 175
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 80-217 3.94e-06

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 48.21  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  80 RDEKVFAEG-------EDLGLMIKTAECRAEHRVLDIGAGAG----HTALAFSPYVqecIGVDATKEMVevasSFAQEKG 148
Cdd:PLN02336  237 RYERVFGEGfvstgglETTKEFVDKLDLKPGQKVLDVGCGIGggdfYMAENFDVHV---VGIDLSVNMI----SFALERA 309

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2564950813 149 VE---NVRFQQGTAESLPFPDDSFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEF 217
Cdd:PLN02336  310 IGrkcSVEFEVADCTKKTYPDNSFDVIYSRDTILHIQDKPALFRSFFKWLKPGGKVLISDYCRSPGTPSPEF 381
PRK14968 PRK14968
putative methyltransferase; Provisional
 81-204 1.45e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 44.89  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  81 DEKVFAEGEDLGLMIKTAECRAEHRVLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAE 160
Cdd:PRK14968    2 NDEVYEPAEDSFLLAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNGVEVIRSD 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2564950813 161 SL-PFPDDSFDIIT--------------CRYAAHHFS---DVRKAV----REVARVLKQDGRFLLV 204
Cdd:PRK14968   82 LFePFRGDKFDVILfnppylpteeeeewDDWLNYALSggkDGREVIdrflDEVGRYLKPGGRILLL 147
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 98-160 3.23e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 45.17  E-value: 3.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2564950813  98 AECRAEHRVLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAE 160
Cdd:COG2265   229 LDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLE 291
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 106-240 6.68e-05

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 43.59  E-value: 6.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 106 VLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVAssfaQEKGVENvRFQQGTAESLPFPDDSFDIITCRYAAHHFSDVR 185
Cdd:PRK10258   46 VLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQA----RQKDAAD-HYLAGDIESLPLATATFDLAWSNLAVQWCGNLS 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2564950813 186 KAVREVARVLKQDGRF---LLVDHYAPEDPVLDEFVN---HLNRLRDPSHVReSSLSEWQA 240
Cdd:PRK10258  121 TALRELYRVVRPGGVVaftTLVQGSLPELHQAWQAVDerpHANRFLPPDAIE-QALNGWRY 180
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 128-205 1.21e-04

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 41.98  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 128 IGVDATKEMVEVAS---SFAQEKGVENVRFQQGTAESLPFPDDSFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLV 204
Cdd:PLN02232    1 MGLDFSSEQLAVAAtrqSLKARSCYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSIL 80


                  .
gi 2564950813 205 D 205
Cdd:PLN02232   81 D 81
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 91-235 1.46e-04

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 42.00  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  91 LGLMIKTAECRAEHRVLDIGAGAG-HTALAfSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAeSLPFPDDS- 168
Cdd:COG2518    55 VARMLEALDLKPGDRVLEIGTGSGyQAAVL-ARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDG-ALGWPEHAp 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2564950813 169 FD--IITCryaahhfsdvrkAVREVARV----LKQDGRfLLVdhyapedPVLDEFVNHLNRL-RDPSHVRESSL 235
Cdd:COG2518   133 FDriIVTA------------AAPEVPEAlleqLAPGGR-LVA-------PVGEGGVQRLVLItRTGDGFERESL 186
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 105-173 1.60e-04

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 42.73  E-value: 1.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2564950813 105 RVLDIGAGAGHTALAFSPYVQEC--IGVDATKEMVEVASSFAQEKGVE-NVRFQQGTAESlPFPDDSFDIIT 173
Cdd:TIGR00536 117 HILDLGTGSGCIALALAYEFPNAevIAVDISPDALAVAEENAEKNQLEhRVEFIQSNLFE-PLAGQKIDIIV 187
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
105-247 1.83e-04

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 42.02  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  105 RVLDIGAGAGH--TALAFSPYVQECIGVDATKEMVEVASSFAQEKGVEN-VRFQQGTAESLPFPdDSFDIITCRYAAHHF 181
Cdd:smart00828   2 RVLDFGCGYGSdlIDLAERHPHLQLHGYTISPEQAEVGRERIRALGLQGrIRIFYRDSAKDPFP-DTYDLVFGFEVIHHI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2564950813  182 SDVRKAVREVARVLKQDGRFLLVDHYA-PEDPVLDEFVNHLNrlrdpshvreSSLSEWQAMFSANQL 247
Cdd:smart00828  81 KDKMDLFSNISRHLKDGGHLVLADFIAnLLSAIEHEETTSYL----------VTREEWAELLARNNL 137
PRK06202 PRK06202
hypothetical protein; Provisional
 105-196 2.12e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 41.91  E-value: 2.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAFSPYVQ------ECIGVDATKEMVEVASSFAQekgVENVRFQQGTAESLPFPDDSFDIITCRYAA 178
Cdd:PRK06202   63 TLLDIGCGGGDLAIDLARWARrdglrlEVTAIDPDPRAVAFARANPR---RPGVTFRQAVSDELVAEGERFDVVTSNHFL 139

                          90
                  ....*....|....*...
gi 2564950813 179 HHFSDVrkavrEVARVLK 196
Cdd:PRK06202  140 HHLDDA-----EVVRLLA 152
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 105-204 3.24e-04

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 41.86  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 105 RVLDIGAGAGHTALAFS---PYVQECIGVDATKEMVEVASSFAQE---KGVENVRFQQGTAESlPFPDDSFDIITCRYAa 178
Cdd:COG5459    83 TVLDVGAGPGTAAWAAAdawPSLLDATLLERSAAALALGRRLARAaanPALETAEWRLADLAA-ALPAPPADLVVASYV- 160

                          90       100
                  ....*....|....*....|....*...
gi 2564950813 179 hhFSDVRKAVRE--VARVLKQDGRFLLV 204
Cdd:COG5459   161 --LNELADAARAalVDRLWLAPDGALLI 186
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 107-205 8.99e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 38.06  E-value: 8.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 107 LDIGAGAGHTALAFSPYVQE-----CIGVDATKEMVEVASSFAQEKGVENVRFQQGTA-ESLP-FPDDSFDIITCRyAAH 179
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAALRDnglgrLTAVDPDPGAEEAGALLRKAGLDDRVRLIVGDSrEALPsLADGPIDLLFID-GDH 79

                          90       100
                  ....*....|....*....|....*.
gi 2564950813 180 HFSDVRKAVREVARVLKQDGrFLLVD 205
Cdd:pfam13578  80 TYEAVLNDLELWLPRLAPGG-VILFH 104
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
105-164 2.38e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 38.50  E-value: 2.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2564950813 105 RVLDIGAGAGHTALAFSPYVQE---CIGVDATKEMVEVASSFAQEKGVENVRF-----QQGTAESLPF 164
Cdd:pfam01135  76 RVLEIGSGSGYLTACFARMVGEvgrVVSIEHIPELVEIARRNLEKLGLENVIVvvgdgRQGWPEFAPY 143
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 104-204 4.06e-03

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 38.35  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 104 HRVLDIGAGAGHtalaFSPYVQECI---------GVDATKEMVEVASsfaqeKGVENVRFQQGTAESLPFPDDSFDIITC 174
Cdd:PRK11088   87 TALLDIGCGEGY----YTHALADALpeittmqlfGLDISKVAIKYAA-----KRYPQVTFCVASSHRLPFADQSLDAIIR 157

                          90       100       110
                  ....*....|....*....|....*....|
gi 2564950813 175 RYAAHhfsdvrKAVrEVARVLKQDGRFLLV 204
Cdd:PRK11088  158 IYAPC------KAE-ELARVVKPGGIVITV 180
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 79-157 4.91e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 38.29  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813  79 YRDEKVFAEGEDLGLM---IKTAECRAEHRVLDIGAGAGHTALAFSPYVQE---CIGVDATKEMVEVASSFAQEKGVENV 152
Cdd:PRK13943   54 YDDGEEYSTSSQPSLMalfMEWVGLDKGMRVLEIGGGTGYNAAVMSRVVGEkglVVSVEYSRKICEIAKRNVRRLGIENV 133


                  ....*
gi 2564950813 153 RFQQG 157
Cdd:PRK13943  134 IFVCG 138
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
101-232 5.73e-03

Predicted methyltransferase [General function prediction only];


Pssm-ID: 443826  Cd Length: 274  Bit Score: 37.97  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564950813 101 RAEHRVLDIGAGAGHTALAFSPYVQEC---IGV--DATKEMVEVASSF---------AQEKGVENVRFQQGTAESLPF-P 165
Cdd:COG4798    65 KPGMTVVEIWPGGGWYTEILAPYLGPKgkvYAAnfDPDSEPPEYAKRSreafsaklaADPALYGNVRVTAFAPPDDPIaP 144

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2564950813 166 DDSFD-IITCRyAAH--HFSDVRKAV-REVARVLKQDGRFLLVDHYAPEDPVLDEfVNHLNRLrDPSHVRE 232
Cdd:COG4798   145 PGSADlVLTFR-NYHnwYRAGDAAAMfAAFFKALKPGGVLGVVDHRAPPGTGLEA-VATLGYI-DEAYVIA 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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