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Conserved domains on  [gi|2568734423|ref|WP_306660016|]
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MULTISPECIES: hypothetical protein [Nostocaceae]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins; NHL is a six-bladed beta-propeller

CATH:  2.40.10.500
Gene Ontology:  GO:0005515
PubMed:  9868369|17979191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 132-302 2.84e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 76.20  E-value: 2.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 132 TGLA-TKDKNLYVSDAANNKIRVHNTETMKELR-------NFSFLRPGDITIDKQGNLWIIqkqDANNpAKILRYSSSGK 203
Cdd:cd05819    11 QGIAvDSSGNIYVADTGNNRIQVFDPDGNFITSfgsfgsgDGQFNEPAGVAVDSDGNLYVA---DTGN-HRIQKFDPDGN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 204 QLPQKITN------VVLPGAIALDNQGRLLVAENGTlQQVLIYNIQDQPvqVGTFGHTGGIYGgvpgevqdlKFYGLTGV 277
Cdd:cd05819    87 FLASFGGSgdgdgeFNGPRGIAVDSSGNIYVADTGN-HRIQKFDPDGEF--LTTFGSGGSGPG---------QFNGPTGV 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2568734423 278 GADTQGNLYI---NNNG---FNNSGTDLRKF 302
Cdd:cd05819   155 AVDSDGNIYVadtGNHRiqvFDPDGNFLTTF 185
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 8-198 7.42e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423   8 GSQKSIQNYIEGMYVAPNGTVY---TNSHedkagaeaSIYK---DGNVIGVLNdlHGWSRHGG----KAVTANSK-YIYI 76
Cdd:cd05819    95 GDGDGEFNGPRGIAVDSSGNIYvadTGNH--------RIQKfdpDGEFLTTFG--SGGSGPGQfngpTGVAVDSDgNIYV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423  77 AMSQGfvgkidkdyppegttwYCVRRYNLSGKPAPFANGRGWDKSMLivntkSEVTGLAT-KDKNLYVSDAANNKIRVHN 155
Cdd:cd05819   165 ADTGN----------------HRIQVFDPDGNFLTTFGSTGTGPGQF-----NYPTGIAVdSDGNIYVADSGNNRVQVFD 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2568734423 156 TETMKELRNFSFL-------RPGDITIDKQGNLWIIqkqDANNPaKILRY 198
Cdd:cd05819   224 PDGAGFGGNGNFLgsdgqfnRPSGLAVDSDGNLYVA---DTGNN-RIQVF 269
 
Name Accession Description Interval E-value
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 132-302 2.84e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 76.20  E-value: 2.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 132 TGLA-TKDKNLYVSDAANNKIRVHNTETMKELR-------NFSFLRPGDITIDKQGNLWIIqkqDANNpAKILRYSSSGK 203
Cdd:cd05819    11 QGIAvDSSGNIYVADTGNNRIQVFDPDGNFITSfgsfgsgDGQFNEPAGVAVDSDGNLYVA---DTGN-HRIQKFDPDGN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 204 QLPQKITN------VVLPGAIALDNQGRLLVAENGTlQQVLIYNIQDQPvqVGTFGHTGGIYGgvpgevqdlKFYGLTGV 277
Cdd:cd05819    87 FLASFGGSgdgdgeFNGPRGIAVDSSGNIYVADTGN-HRIQKFDPDGEF--LTTFGSGGSGPG---------QFNGPTGV 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2568734423 278 GADTQGNLYI---NNNG---FNNSGTDLRKF 302
Cdd:cd05819   155 AVDSDGNIYVadtGNHRiqvFDPDGNFLTTF 185
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
138-309 1.57e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 53.10  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 138 DKNLYVSDAANNKIRVHN--TETMKELRNFSFLRPGDITIDKQGNLWIIqkqDANNpAKILRYSSSGKqlpqKITNVVLP 215
Cdd:COG4257    27 DGAVWFTDQGGGRIGRLDpaTGEFTEYPLGGGSGPHGIAVDPDGNLWFT---DNGN-NRIGRIDPKTG----EITTFALP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 216 G------AIALDNQGRLLVAENGTlQQVLIYNIQDQPVQVGTFGHTGGiyggvpgevqdlkfyGLTGVGADTQGNLYINN 289
Cdd:COG4257    99 GggsnphGIAFDPDGNLWFTDQGG-NRIGRLDPATGEVTEFPLPTGGA---------------GPYGIAVDPDGNLWVTD 162

                         170       180
                  ....*....|....*....|
gi 2568734423 290 NGFNNsgtdLRKFSPSGKQL 309
Cdd:COG4257   163 FGANA----IGRIDPDTGTL 178
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 8-198 7.42e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423   8 GSQKSIQNYIEGMYVAPNGTVY---TNSHedkagaeaSIYK---DGNVIGVLNdlHGWSRHGG----KAVTANSK-YIYI 76
Cdd:cd05819    95 GDGDGEFNGPRGIAVDSSGNIYvadTGNH--------RIQKfdpDGEFLTTFG--SGGSGPGQfngpTGVAVDSDgNIYV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423  77 AMSQGfvgkidkdyppegttwYCVRRYNLSGKPAPFANGRGWDKSMLivntkSEVTGLAT-KDKNLYVSDAANNKIRVHN 155
Cdd:cd05819   165 ADTGN----------------HRIQVFDPDGNFLTTFGSTGTGPGQF-----NYPTGIAVdSDGNIYVADSGNNRVQVFD 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2568734423 156 TETMKELRNFSFL-------RPGDITIDKQGNLWIIqkqDANNPaKILRY 198
Cdd:cd05819   224 PDGAGFGGNGNFLgsdgqfnRPSGLAVDSDGNLYVA---DTGNN-RIQVF 269
 
Name Accession Description Interval E-value
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 132-302 2.84e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 76.20  E-value: 2.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 132 TGLA-TKDKNLYVSDAANNKIRVHNTETMKELR-------NFSFLRPGDITIDKQGNLWIIqkqDANNpAKILRYSSSGK 203
Cdd:cd05819    11 QGIAvDSSGNIYVADTGNNRIQVFDPDGNFITSfgsfgsgDGQFNEPAGVAVDSDGNLYVA---DTGN-HRIQKFDPDGN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 204 QLPQKITN------VVLPGAIALDNQGRLLVAENGTlQQVLIYNIQDQPvqVGTFGHTGGIYGgvpgevqdlKFYGLTGV 277
Cdd:cd05819    87 FLASFGGSgdgdgeFNGPRGIAVDSSGNIYVADTGN-HRIQKFDPDGEF--LTTFGSGGSGPG---------QFNGPTGV 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2568734423 278 GADTQGNLYI---NNNG---FNNSGTDLRKF 302
Cdd:cd05819   155 AVDSDGNIYVadtGNHRiqvFDPDGNFLTTF 185
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 99-293 2.34e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 61.57  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423  99 CVRRYNLSGKPAPFANGRGWDKSMLivntkSEVTGLAT-KDKNLYVSDAANNKIRVHNTETmKELRNF--------SFLR 169
Cdd:cd05819    77 RIQKFDPDGNFLASFGGSGDGDGEF-----NGPRGIAVdSSGNIYVADTGNHRIQKFDPDG-EFLTTFgsggsgpgQFNG 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 170 PGDITIDKQGNLWIIqkqDANNpAKILRYSSSG---KQLPQKITNVVL---PGAIALDNQGRLLVAENGTlQQVLIYNIQ 243
Cdd:cd05819   151 PTGVAVDSDGNIYVA---DTGN-HRIQVFDPDGnflTTFGSTGTGPGQfnyPTGIAVDSDGNIYVADSGN-NRVQVFDPD 225

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2568734423 244 DQpvQVGTFGHTGGIYGGvpgevqdlkFYGLTGVGADTQGNLYINNNGFN 293
Cdd:cd05819   226 GA--GFGGNGNFLGSDGQ---------FNRPSGLAVDSDGNLYVADTGNN 264
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 132-287 6.32e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 60.38  E-value: 6.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 132 TGLATKDKNLYVSDAANNKIRVHNTETmKELRNFS--------FLRPGDITIDKQGNLWIIqkqDANNpAKILRYSSSGK 203
Cdd:cd14963   105 AGLAIDDGKLYVSDVKKHKVIVFDLEG-KLLLEFGkpgsepgeLSYPNGIAVDEDGNIYVA---DSGN-GRIQVFDKNGK 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 204 QL------PQKITNVVLPGAIALDNQGRLLVAENGTlQQVLIYNIQdqpvqvGTFGHTGGIYGGVPGEvqdlkFYGLTGV 277
Cdd:cd14963   180 FIkelngsPDGKSGFVNPRGIAVDPDGNLYVVDNLS-HRVYVFDEQ------GKELFTFGGRGKDDGQ-----FNLPNGL 247

                         170
                  ....*....|
gi 2568734423 278 GADTQGNLYI 287
Cdd:cd14963   248 FIDDDGRLYV 257
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 140-290 1.17e-08

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 56.77  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 140 NLYVSDAANNKIRV----------------------HNTETMkelrnfsFLRPGDITIDKQGNLWIiqkQDANNpAKILR 197
Cdd:cd14953   144 NLYVADTGNHRIRKitpdgvvttvagtggagyagdgPATAAQ-------FNNPTGVAVDAAGNLYV---ADRGN-HRIRK 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 198 YSSSGKqlpqkITNVV-------------------LPGAIALDNQGRLLVAE--NGTLQQVliyniqDQPVQVGTFGHTG 256
Cdd:cd14953   213 ITPDGV-----VTTVAgtgtagfsgdggataaqlnNPTGVAVDAAGNLYVADsgNHRIRKI------TPAGVVTTVAGGG 281

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2568734423 257 GIYGGVPGEVQDLKFYGLTGVGADTQGNLYI---NNN 290
Cdd:cd14953   282 AGFSGDGGPATSAQFNNPTGVAVDAAGNLYVadtGNN 318
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 167-307 9.41e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 53.86  E-value: 9.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 167 FLRPGDITIDKQGNLWI-------IQKQDANNpAKILRYSSSGKQLPQKITnvvlPGAIALDNQGRLLVAENGtLQQVLI 239
Cdd:cd05819     7 LNNPQGIAVDSSGNIYVadtgnnrIQVFDPDG-NFITSFGSFGSGDGQFNE----PAGVAVDSDGNLYVADTG-NHRIQK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2568734423 240 YNIQdqpvqvGTFGHTGGIYGGVPGEvqdlkFYGLTGVGADTQGNLYINNNGfNNSgtdLRKFSPSGK 307
Cdd:cd05819    81 FDPD------GNFLASFGGSGDGDGE-----FNGPRGIAVDSSGNIYVADTG-NHR---IQKFDPDGE 133
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 138-309 1.00e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 53.75  E-value: 1.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 138 DKNLYVSDAANNKIRVHNTETmKELRNFS----FLRPGDITIDKQGNLWIIQKQDANnpaKILRYSSSGKQL-------- 205
Cdd:cd14962    67 NGNLYVSDAELGKVFVFDRDG-KFLRAIGagalFKRPTGIAVDPAGKRLYVVDTLAH---KVKVFDLDGRLLfdigkrgs 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 206 -PQKITnvvLPGAIALDNQGRLLVAE--NGTLQqvlIYNIQDQPVQvgTFGHTggiyGGVPGEVQDLKfygltGVGADTQ 282
Cdd:cd14962   143 gPGEFN---LPTDLAVDRDGNLYVTDtmNFRVQ---IFDADGKFLR--SFGER----GDGPGSFARPK-----GIAVDSE 205

                         170       180
                  ....*....|....*....|....*..
gi 2568734423 283 GNLYINNNGFNNsgtdLRKFSPSGKQL 309
Cdd:cd14962   206 GNIYVVDAAFDN----VQIFNPEGELL 228
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 131-308 1.41e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 53.06  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 131 VTGLA-TKDKNLYVSDAANNKIRVHNTETMKELRNFS-------FLRPGDITIDKQGNLWIIqkqDANNpAKILRYSSSG 202
Cdd:cd14956    15 PRGIAvDADDNVYVADARNGRIQVFDKDGTFLRRFGTtgdgpgqFGRPRGLAVDKDGWLYVA---DYWG-DRIQVFTLTG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 203 KqlPQKITNV--------VLPGAIALDNQGRLLVAENGTlqqvliyniqdQPVQV----GTFGHTGGIYGGVPGEvqdlk 270
Cdd:cd14956    91 E--LQTIGGSsgsgpgqfNAPRGVAVDADGNLYVADFGN-----------QRIQKfdpdGSFLRQWGGTGIEPGS----- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2568734423 271 FYGLTGVGADTQGNLYI---NNNG---FNNSGTDLRKFSPSGKQ 308
Cdd:cd14956   153 FNYPRGVAVDPDGTLYVadtYNDRiqvFDNDGAFLRKWGGRGTG 196
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
138-309 1.57e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 53.10  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 138 DKNLYVSDAANNKIRVHN--TETMKELRNFSFLRPGDITIDKQGNLWIIqkqDANNpAKILRYSSSGKqlpqKITNVVLP 215
Cdd:COG4257    27 DGAVWFTDQGGGRIGRLDpaTGEFTEYPLGGGSGPHGIAVDPDGNLWFT---DNGN-NRIGRIDPKTG----EITTFALP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 216 G------AIALDNQGRLLVAENGTlQQVLIYNIQDQPVQVGTFGHTGGiyggvpgevqdlkfyGLTGVGADTQGNLYINN 289
Cdd:COG4257    99 GggsnphGIAFDPDGNLWFTDQGG-NRIGRLDPATGEVTEFPLPTGGA---------------GPYGIAVDPDGNLWVTD 162

                         170       180
                  ....*....|....*....|
gi 2568734423 290 NGFNNsgtdLRKFSPSGKQL 309
Cdd:COG4257   163 FGANA----IGRIDPDTGTL 178
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 140-306 2.26e-07

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 52.92  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 140 NLYVSDAANNKIRVHNTETM---------------KELRNFSFLRPGDITIDKQGNLWIiqkQDANNpAKILRYSSSGKq 204
Cdd:cd14953    89 NLYVADTGNHRIRKITPDGVvstlagtgtagfsddGGATAAQFNYPTGVAVDAAGNLYV---ADTGN-HRIRKITPDGV- 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 205 lpqkITNVV-------------------LPGAIALDNQGRLLVAE--NGTLQQVliyniqDQPVQVGTFGHTGGIYGGVP 263
Cdd:cd14953   164 ----VTTVAgtggagyagdgpataaqfnNPTGVAVDAAGNLYVADrgNHRIRKI------TPDGVVTTVAGTGTAGFSGD 233

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2568734423 264 GEVQDLKFYGLTGVGADTQGNLYINNNGfNNSgtdLRKFSPSG 306
Cdd:cd14953   234 GGATAAQLNNPTGVAVDAAGNLYVADSG-NHR---IRKITPAG 272
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
92-306 2.66e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 52.33  E-value: 2.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423  92 PEGTTWYC------VRRYNL-SGKPAPFANGRGwdksmlivntkSEVTGLAT-KDKNLYVSDAANNKIRVHNTETmKELR 163
Cdd:COG4257    26 PDGAVWFTdqgggrIGRLDPaTGEFTEYPLGGG-----------SGPHGIAVdPDGNLWFTDNGNNRIGRIDPKT-GEIT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 164 NFSF----LRPGDITIDKQGNLWIIqkqdANNPAKILRYS-SSGK----QLPQKITNvvlPGAIALDNQGRLLVAENGTl 234
Cdd:COG4257    94 TFALpgggSNPHGIAFDPDGNLWFT----DQGGNRIGRLDpATGEvtefPLPTGGAG---PYGIAVDPDGNLWVTDFGA- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 235 QQVLIYNIQD-------------QPVQVgTFGHTGGIY------GGV------PGEVQDLKFYGL----TGVGADTQGNL 285
Cdd:COG4257   166 NAIGRIDPDTgtlteyalptpgaGPRGL-AVDPDGNLWvadtgsGRIgrfdpkTGTVTEYPLPGGgarpYGVAVDGDGRV 244

                         250       260
                  ....*....|....*....|..
gi 2568734423 286 YinnngFNNSGTD-LRKFSPSG 306
Cdd:COG4257   245 W-----FAESGANrIVRFDPDT 261
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 141-309 1.31e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 50.28  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 141 LYVSDAANNKIRVHNTETmKELRNF------SFLRPGDITIDKQGNLWIiqkQDANNpAKILRYSSSGKQLPqKITNVVL 214
Cdd:cd14962    25 IYVADTGRGAVFVFDLPN-GKVFVIgnagpnRFVSPIGVAIDANGNLYV---SDAEL-GKVFVFDRDGKFLR-AIGAGAL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 215 ---PGAIALDN-QGRLLVAENGtLQQVLIYNIQDQpvQVGTFGHTGGIyggvPGEvqdlkFYGLTGVGADTQGNLYINNN 290
Cdd:cd14962    99 fkrPTGIAVDPaGKRLYVVDTL-AHKVKVFDLDGR--LLFDIGKRGSG----PGE-----FNLPTDLAVDRDGNLYVTDT 166

                         170       180
                  ....*....|....*....|....*
gi 2568734423 291 G------FNNSGTDLRKFSPSGKQL 309
Cdd:cd14962   167 MnfrvqiFDADGKFLRSFGERGDGP 191
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 133-325 4.24e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 48.44  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 133 GLATKDKNLYVSDAANNKIRVHNTETM---------KELRNFSFlrPGDITIDKQGNLWIiqkQDANNpAKILRYSSSGK 203
Cdd:cd14963    14 GVAVSDGRIYVADTNNHRVQVFDYEGKfkksfggpgTGPGEFKY--PYGIAVDSDGNIYV---ADLYN-GRIQVFDPDGK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 204 QL-----PQKITNVVLPGAIALDNqGRLLVAENGTlQQVLIYNIQdqpvqvGTFGHTGGIYGGVPGEvqdlkFYGLTGVG 278
Cdd:cd14963    88 FLkyfpeKKDRVKLISPAGLAIDD-GKLYVSDVKK-HKVIVFDLE------GKLLLEFGKPGSEPGE-----LSYPNGIA 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2568734423 279 ADTQGNLYINNNG------FNNSGTDLRKF--SPSGKQlwrllGLSLVENADVDP 325
Cdd:cd14963   155 VDEDGNIYVADSGngriqvFDKNGKFIKELngSPDGKS-----GFVNPRGIAVDP 204
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 140-306 5.05e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 48.42  E-value: 5.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 140 NLYVSDAANNKIRVHNTET-------MKELRNFSFLRPGDITIDKQGNLWIIqkqDANNpAKILRYSSSGKQL------P 206
Cdd:cd14957    77 NIYVADTDNNRIQVFNSSGvyqysigTGGSGDGQFNGPYGIAVDSNGNIYVA---DTGN-HRIQVFTSSGTFSysigsgG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 207 QKITNVVLPGAIALDNQGRLLVAENGtlqqvliyniqDQPVQV----GTFGHTGGIYGGVPGEvqdlkFYGLTGVGADTQ 282
Cdd:cd14957   153 TGPGQFNGPQGIAVDSDGNIYVADTG-----------NHRIQVftssGTFQYTFGSSGSGPGQ-----FSDPYGIAVDSD 216

                         170       180       190
                  ....*....|....*....|....*....|
gi 2568734423 283 GNLYINNNG------FNNSGTDLRKFSPSG 306
Cdd:cd14957   217 GNIYVADTGnhriqvFTSSGAYQYSIGTSG 246
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 132-307 5.81e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 48.06  E-value: 5.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 132 TGLA-TKDKNLYVSDAANNKIRVHNTETmKELRNF-------SFLRPGDITIDKqGNLWIIQkqdaNNPAKILRYSSSGK 203
Cdd:cd14963    59 YGIAvDSDGNIYVADLYNGRIQVFDPDG-KFLKYFpekkdrvKLISPAGLAIDD-GKLYVSD----VKKHKVIVFDLEGK 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 204 QL------PQKITNVVLPGAIALDNQGRLLVAENGTlQQVLIYNIQDQPVQVgtfghtggIYGGVPGEVQdlkFYGLTGV 277
Cdd:cd14963   133 LLlefgkpGSEPGELSYPNGIAVDEDGNIYVADSGN-GRIQVFDKNGKFIKE--------LNGSPDGKSG---FVNPRGI 200

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2568734423 278 GADTQGNLYINNN------GFNNSGTDLRKFSPSGK 307
Cdd:cd14963   201 AVDPDGNLYVVDNlshrvyVFDEQGKELFTFGGRGK 236
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 8-198 7.42e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423   8 GSQKSIQNYIEGMYVAPNGTVY---TNSHedkagaeaSIYK---DGNVIGVLNdlHGWSRHGG----KAVTANSK-YIYI 76
Cdd:cd05819    95 GDGDGEFNGPRGIAVDSSGNIYvadTGNH--------RIQKfdpDGEFLTTFG--SGGSGPGQfngpTGVAVDSDgNIYV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423  77 AMSQGfvgkidkdyppegttwYCVRRYNLSGKPAPFANGRGWDKSMLivntkSEVTGLAT-KDKNLYVSDAANNKIRVHN 155
Cdd:cd05819   165 ADTGN----------------HRIQVFDPDGNFLTTFGSTGTGPGQF-----NYPTGIAVdSDGNIYVADSGNNRVQVFD 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2568734423 156 TETMKELRNFSFL-------RPGDITIDKQGNLWIIqkqDANNPaKILRY 198
Cdd:cd05819   224 PDGAGFGGNGNFLgsdgqfnRPSGLAVDSDGNLYVA---DTGNN-RIQVF 269
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 140-308 8.92e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 44.56  E-value: 8.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 140 NLYVSDAANNKIRVHNTETMKELR-------NFSFLRPGDITIDKQGNLWIIQKQDAN----NPAKILRYSSSGKQLPQK 208
Cdd:cd14957    30 NIYVADTGNNRIQVFTSSGVYSYSigsggtgSGQFNSPYGIAVDSNGNIYVADTDNNRiqvfNSSGVYQYSIGTGGSGDG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 209 ITNVvlPGAIALDNQGRLLVAENGTlqqvliyNIqdqpVQV----GTFGHTGGIYGGVPGEvqdlkFYGLTGVGADTQGN 284
Cdd:cd14957   110 QFNG--PYGIAVDSNGNIYVADTGN-------HR----IQVftssGTFSYSIGSGGTGPGQ-----FNGPQGIAVDSDGN 171

                         170       180       190
                  ....*....|....*....|....*....|
gi 2568734423 285 LYINNNG------FNNSGTDLRKFSPSGKQ 308
Cdd:cd14957   172 IYVADTGnhriqvFTSSGTFQYTFGSSGSG 201
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 137-240 1.08e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.20  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 137 KDKNLYVSDAANNKIRVH--NTETMKELRN-----FSFLRPGDITIDKQGNLWIIQKQDAN------NPAKILRYSSSGK 203
Cdd:cd14963   157 EDGNIYVADSGNGRIQVFdkNGKFIKELNGspdgkSGFVNPRGIAVDPDGNLYVVDNLSHRvyvfdeQGKELFTFGGRGK 236

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2568734423 204 QLPQkitnVVLPGAIALDNQGRLLVAENGtLQQVLIY 240
Cdd:cd14963   237 DDGQ----FNLPNGLFIDDDGRLYVTDRE-NNRVAVY 268
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 133-304 1.54e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 43.72  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 133 GLAT-KDKNLYVSDAANNKIRVHN---TETMK----ELRNFSFLRPGDITIDKQGNLWIIqkqDANNPaKILRYSSSGKQ 204
Cdd:cd14955   114 GIAVdSAGNVYVTDSGNNRIQKFDssgTFITKwgsfGSGDGQFNSPTGIAVDSAGNVYVA---DTGNN-RIQKFTSTGTF 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 205 LPQKITN------VVLPGAIALDNQGRLLVAENGTlQQVLIYNiqdqpvQVGTFGHTGGIYGGVPGEvqdlkFYGLTGVG 278
Cdd:cd14955   190 LTKWGSEgsgdgqFNAPYGIAVDSAGNVYVADTGN-NRIQKFD------SSGTFITKWGSEGSGDGQ-----FNSPSGIA 257

                         170       180
                  ....*....|....*....|....*.
gi 2568734423 279 ADTQGNLYINNNGfNNsgtDLRKFSP 304
Cdd:cd14955   258 VDSAGNVYVADSG-NN---RIQKFAP 279
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 132-230 1.76e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 44.06  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 132 TGLAT-KDKNLYVSDAANNKIR----------VHNTETM-----KELRNFSFLRPGDITIDKQGNLWIIqkqDANNpAKI 195
Cdd:cd14953   190 TGVAVdAAGNLYVADRGNHRIRkitpdgvvttVAGTGTAgfsgdGGATAAQLNNPTGVAVDAAGNLYVA---DSGN-HRI 265

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2568734423 196 LRYSSSGKQL--------------PQKITNVVLPGAIALDNQGRLLVAE 230
Cdd:cd14953   266 RKITPAGVVTtvagggagfsgdggPATSAQFNNPTGVAVDAAGNLYVAD 314
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 130-290 2.74e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 130 EVTGLAT-KDKNLYVSDAANNKIrVHNTETMKELRNF--------SFLRPGDITIDKQGNLWIiqkQDANNpAKILRYSS 200
Cdd:cd14956   108 APRGVAVdADGNLYVADFGNQRI-QKFDPDGSFLRQWggtgiepgSFNYPRGVAVDPDGTLYV---ADTYN-DRIQVFDN 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 201 SGKQLPQKITNVVLPG------AIALDNQGRLLVAEngtlqqvlIYNiqdQPVQV----GTFGHTGGIYGGVPGEvqdlk 270
Cdd:cd14956   183 DGAFLRKWGGRGTGPGqfnypyGIAIDPDGNVFVAD--------FGN---NRIQKftadGTFLTSWGSPGTGPGQ----- 246

                         170       180
                  ....*....|....*....|...
gi 2568734423 271 FYGLTGVGADTQGNLYI---NNN 290
Cdd:cd14956   247 FKNPWGVVVDADGTVYVadsNNN 269
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 100-309 5.92e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.80  E-value: 5.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 100 VRRYNLSGK-------PAPFANGRGWDK--SMLIVNTKSEVTGLatkdknlyvsDAANNKIRVHNTETMKELRnfsflRP 170
Cdd:COG3386    31 IHRYDPDGGavevfaePSGRPNGLAFDPdgRLLVADHGRGLVRF----------DPADGEVTVLADEYGKPLN-----RP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 171 GDITIDKQGNLWIIQKQDANNPAKILRYSSSGKqLPQKITNVVLPGAIALDNQGR-LLVAENGTlQQVLIYNIQDQpvqv 249
Cdd:COG3386    96 NDGVVDPDGRLYFTDMGEYLPTGALYRVDPDGS-LRVLADGLTFPNGIAFSPDGRtLYVADTGA-GRIYRFDLDAD---- 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2568734423 250 GTFG-----HTGGIYGGVPgevqDlkfyGLTgvgADTQGNLYINNNGFNNsgtdLRKFSPSGKQL 309
Cdd:COG3386   170 GTLGnrrvfADLPDGPGGP----D----GLA---VDADGNLWVALWGGGG----VVRFDPDGELL 219
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 132-306 7.09e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 41.79  E-value: 7.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 132 TGLAT-KDKNLYVSDAANNKIRVHNTetmkelrNFSFLR--------------PGDITIDKQGNLWIIqkqDANNPaKIL 196
Cdd:cd14955    66 TGIAVdSDGNVYVADTGNHRIQKFDS-------TGTFLTkwgssgsgdgqfnsPSGIAVDSAGNVYVT---DSGNN-RIQ 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 197 RYSSSGKQLPQ------KITNVVLPGAIALDNQGRLLVAENGTlQQVLIYNIQdqpvqvGTFGHTGGIYGGVPGEvqdlk 270
Cdd:cd14955   135 KFDSSGTFITKwgsfgsGDGQFNSPTGIAVDSAGNVYVADTGN-NRIQKFTST------GTFLTKWGSEGSGDGQ----- 202

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2568734423 271 FYGLTGVGADTQGNLYINNNGfNNSgtdLRKFSPSG 306
Cdd:cd14955   203 FNAPYGIAVDSAGNVYVADTG-NNR---IQKFDSSG 234
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 140-306 1.77e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 40.64  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 140 NLYVSDAANNKIRVHNTeTMKELRNF--------SFLRPGDITIDKQGNLWI-------IQKQDAN--NPAKILRYSSSG 202
Cdd:cd14955    28 NVYVADTGNNRIQKFDS-TGTFLTKWgssgsgdgQFYSPTGIAVDSDGNVYVadtgnhrIQKFDSTgtFLTKWGSSGSGD 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 203 KQLPQkitnvvlPGAIALDNQGRLLVAENGTlQQVLIYNIQdqpvqvGTFGHTGGIYGGVPGEvqdlkFYGLTGVGADTQ 282
Cdd:cd14955   107 GQFNS-------PSGIAVDSAGNVYVTDSGN-NRIQKFDSS------GTFITKWGSFGSGDGQ-----FNSPTGIAVDSA 167

                         170       180       190
                  ....*....|....*....|....*....|
gi 2568734423 283 GNLYI---NNN---GFNNSGTDLRKFSPSG 306
Cdd:cd14955   168 GNVYVadtGNNriqKFTSTGTFLTKWGSEG 197
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 132-326 4.31e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 39.18  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 132 TGLA-TKDKNLYVSDAANNKIRVHNTE-------TMKELRNFSFLRPGDITIDKQGNLWIIQKQDanNPAKIlrYSSSGK 203
Cdd:cd14961    14 TGVAvTPTGRVVVADDGNKRIQVFDSDgnclqqfGPKGDAGQDIRYPLDVAVTPDGHIVVTDAGD--RSVKV--FSFDGR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 204 QLPQKITNVVLPGAIALDNQGRLLVA--ENGTLqqvliyniqdqpVQVGTFGHTGGI--YGGVPGEVQDLKF--YGLTGV 277
Cdd:cd14961    90 LKLFVRKSFSLPWGVAVNPSGEILVTdsEAGKL------------FVLTVDFKLGILkkGQKLCSQLCRPRFvaVSRLGA 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2568734423 278 GADTQGnlyINNNGFNNSGTDLRKFSpSGKQLWR---LLGLSLVENADVDPT 326
Cdd:cd14961   158 VAVTEH---LFANGTRSSSTRVKVFS-SGGQLLGqidSFGLNLVFPSLICAS 205
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 173-312 4.46e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 39.10  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 173 ITIDKQGNLWIIqkqDANNPaKILRYSSSGKQLPQKITNVVLPGAIALDNQGRLLVAENGtlQQVLIYNIQDQPVQVgtf 252
Cdd:COG3386    13 PVWDPDGRLYWV---DIPGG-RIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHG--RGLVRFDPADGEVTV--- 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 253 ghtggiyggVPGEVqDLKFYGLTGVGADTQGNLYInnngfnnsgTDLRKFSPSGkQLWRL 312
Cdd:COG3386    84 ---------LADEY-GKPLNRPNDGVVDPDGRLYF---------TDMGEYLPTG-ALYRV 123
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
134-233 6.06e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.52  E-value: 6.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 134 LATKDKNLYVSDAANNKIRVHNTETMKELRNFSF-LRPGDITIDKQGN------------LWIIQKQDANNPAKIlryss 200
Cdd:COG3391   117 VDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVgAGPHGIAVDPDGKrlyvansgsntvSVIVSVIDTATGKVV----- 191

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2568734423 201 sgkqlpQKITNVVLPGAIALDNQGR-LLVAENGT 233
Cdd:COG3391   192 ------ATIPVGGGPVGVAVSPDGRrLYVANRGS 219
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 138-241 6.24e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 38.79  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568734423 138 DKNLYVSDAANNKIRVHNTETMKELR-------NFSFLRPGDITIDKQGNLWIIqkqDANNpAKILRYSSSGKQLPQKIT 210
Cdd:cd14957   169 DGNIYVADTGNHRIQVFTSSGTFQYTfgssgsgPGQFSDPYGIAVDSDGNIYVA---DTGN-HRIQVFTSSGAYQYSIGT 244

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2568734423 211 NVVLPG------AIALDNQGRLLVAENGTlQQVLIYN 241
Cdd:cd14957   245 SGSGNGqfnypyGIAVDNDGKIYVADSNN-NRIQVFN 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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