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Conserved domains on  [gi|2569584920|ref|WP_306823531|]
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NAD(P)/FAD-dependent oxidoreductase [Qipengyuania flava]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11465281)

NAD(P)/FAD-dependent oxidoreductase such as polyamine oxidase (PAO), flavin-containing monoamine oxidases (MAOs), D-amino acid dehydrogenase, and linoleic acid isomerase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
7-318 2.03e-125

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


:

Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 361.89  E-value: 2.03e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920   7 AMQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVEAdgtmLRFDHGAQYFTARDPRFVEQVARWEREGV 86
Cdd:COG3380     3 MPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGGRMATRRLDG----GRFDHGAQYFTARDPRFQALVEEWLAAGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  87 VARW---------------DVAGEDAWVGTPAMNAPIKAMAGRHDVQFGTRIEQLLRDGDRWQL-DGDGAPDRRFDAVVV 150
Cdd:COG3380    79 VAPWtfdfvvldadglvspRDDGEPRYVGVPGMNALAKHLAAGLDVRLGTRVTALERDGDGWRLtDEDGEEYGPFDAVVL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920 151 ALPAEQAGPLLQP-HASAMGNLADATSSDPCWTVMAAFEQRLPSEQDSIR-HHGAIGWAARNNAKPGRGSAECWVVQASP 228
Cdd:COG3380   159 AIPAPQAAALLEPsLAPELAAALASVRYRPCWAVMLGFDQPLDPDWDAAFvDDGPLAWIARDSSKPGRPGEEAWVLHASP 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920 229 DWSRAHLEDEATAVETALLDQLADAIGAPLPPRLAISAHRWRFARSGSA-GEEALWDAQQRIGVCGDWLIGPRVEAAYLS 307
Cdd:COG3380   239 EWSREHLDDDPEEVAAALLAAFAELLGLPLAEPDWAQAHRWRYALPEAPlGAPFLWDADLGLGLCGDWCAGGRVEGAWLS 318

                         330
                  ....*....|.
gi 2569584920 308 GLLLAETVGGR 318
Cdd:COG3380   319 GLALARALLAR 329
 
Name Accession Description Interval E-value
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
7-318 2.03e-125

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 361.89  E-value: 2.03e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920   7 AMQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVEAdgtmLRFDHGAQYFTARDPRFVEQVARWEREGV 86
Cdd:COG3380     3 MPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGGRMATRRLDG----GRFDHGAQYFTARDPRFQALVEEWLAAGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  87 VARW---------------DVAGEDAWVGTPAMNAPIKAMAGRHDVQFGTRIEQLLRDGDRWQL-DGDGAPDRRFDAVVV 150
Cdd:COG3380    79 VAPWtfdfvvldadglvspRDDGEPRYVGVPGMNALAKHLAAGLDVRLGTRVTALERDGDGWRLtDEDGEEYGPFDAVVL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920 151 ALPAEQAGPLLQP-HASAMGNLADATSSDPCWTVMAAFEQRLPSEQDSIR-HHGAIGWAARNNAKPGRGSAECWVVQASP 228
Cdd:COG3380   159 AIPAPQAAALLEPsLAPELAAALASVRYRPCWAVMLGFDQPLDPDWDAAFvDDGPLAWIARDSSKPGRPGEEAWVLHASP 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920 229 DWSRAHLEDEATAVETALLDQLADAIGAPLPPRLAISAHRWRFARSGSA-GEEALWDAQQRIGVCGDWLIGPRVEAAYLS 307
Cdd:COG3380   239 EWSREHLDDDPEEVAAALLAAFAELLGLPLAEPDWAQAHRWRYALPEAPlGAPFLWDADLGLGLCGDWCAGGRVEGAWLS 318

                         330
                  ....*....|.
gi 2569584920 308 GLLLAETVGGR 318
Cdd:COG3380   319 GLALARALLAR 329
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
12-80 9.89e-16

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 70.64  E-value: 9.89e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2569584920  12 IVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVeaDGtmLRFDHGAQYFTARDPRFVEQVAR 80
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRV--PG--YVFDYGAHIFHGSDEPNVRDLLD 65
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 10-44 3.31e-08

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 54.40  E-value: 3.31e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGG 44
Cdd:PRK12810  146 VAVVGSGPAGLAAADQLARAGHKVTVFERADRIGG 180
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 12-76 7.79e-07

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 50.35  E-value: 7.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569584920  12 IVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRmaTRRVEADGtmLRFDHGAQYFTarDPRFVE 76
Cdd:TIGR02734   3 VIGAGFGGLALAIRLAAAGIPVTVVEQRDKPGGR--AGVLEDDG--FRFDTGPTVIT--MPEALE 61
 
Name Accession Description Interval E-value
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
7-318 2.03e-125

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 361.89  E-value: 2.03e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920   7 AMQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVEAdgtmLRFDHGAQYFTARDPRFVEQVARWEREGV 86
Cdd:COG3380     3 MPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGGRMATRRLDG----GRFDHGAQYFTARDPRFQALVEEWLAAGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  87 VARW---------------DVAGEDAWVGTPAMNAPIKAMAGRHDVQFGTRIEQLLRDGDRWQL-DGDGAPDRRFDAVVV 150
Cdd:COG3380    79 VAPWtfdfvvldadglvspRDDGEPRYVGVPGMNALAKHLAAGLDVRLGTRVTALERDGDGWRLtDEDGEEYGPFDAVVL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920 151 ALPAEQAGPLLQP-HASAMGNLADATSSDPCWTVMAAFEQRLPSEQDSIR-HHGAIGWAARNNAKPGRGSAECWVVQASP 228
Cdd:COG3380   159 AIPAPQAAALLEPsLAPELAAALASVRYRPCWAVMLGFDQPLDPDWDAAFvDDGPLAWIARDSSKPGRPGEEAWVLHASP 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920 229 DWSRAHLEDEATAVETALLDQLADAIGAPLPPRLAISAHRWRFARSGSA-GEEALWDAQQRIGVCGDWLIGPRVEAAYLS 307
Cdd:COG3380   239 EWSREHLDDDPEEVAAALLAAFAELLGLPLAEPDWAQAHRWRYALPEAPlGAPFLWDADLGLGLCGDWCAGGRVEGAWLS 318

                         330
                  ....*....|.
gi 2569584920 308 GLLLAETVGGR 318
Cdd:COG3380   319 GLALARALLAR 329
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
12-80 9.89e-16

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 70.64  E-value: 9.89e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2569584920  12 IVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVeaDGtmLRFDHGAQYFTARDPRFVEQVAR 80
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRV--PG--YVFDYGAHIFHGSDEPNVRDLLD 65
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 8-72 9.79e-11

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 62.17  E-value: 9.79e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMatRRVEADGTmlRFDHGAQYFTARDP 72
Cdd:COG1233     4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRA--RTFERPGF--RFDVGPSVLTMPGV 64
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 8-76 1.30e-10

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 61.77  E-value: 1.30e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVeaDGtmLRFDHGAQYFTARDPRFVE 76
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGLIRTVEV--DG--FRIDRGPHSFLTRDPEVLE 66
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
1-67 1.70e-09

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 58.39  E-value: 1.70e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2569584920   1 MPEADGAMQIAIVGAGMAGLSCATRLAALGHDVALFD-KGRgPGGRMATRRVEADGtmLRFDHGAQYF 67
Cdd:COG1231     1 MSRRARGKDVVIVGAGLAGLAAARELRKAGLDVTVLEaRDR-VGGRVWTLRFGDDG--LYAELGAMRI 65
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 7-63 1.09e-08

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 56.02  E-value: 1.09e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2569584920   7 AMQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRmaTRRVEADGTMLRFDHG 63
Cdd:COG3349     3 PPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGGR--ARSFPDPDTGLPIDNG 57
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 10-164 1.11e-08

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 56.02  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRR-------VEADGTMLRFdhgAQYFTArDPRFV--EQVAR 80
Cdd:COG2072     9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNRypglrldTPSHLYSLPF---FPNWSD-DPDFPtgDEILA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  81 WEREgVVARWDVagedawvgtpamnapikamagRHDVQFGTRIEQL--LRDGDRWQLDGDGAPDRRFDAVVVAlpaeqAG 158
Cdd:COG2072    85 YLEA-YADKFGL---------------------RRPIRFGTEVTSArwDEADGRWTVTTDDGETLTARFVVVA-----TG 137


                  ....*.
gi 2569584920 159 PLLQPH 164
Cdd:COG2072   138 PLSRPK 143
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 10-44 3.31e-08

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 54.40  E-value: 3.31e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGG 44
Cdd:PRK12810  146 VAVVGSGPAGLAAADQLARAGHKVTVFERADRIGG 180
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 10-160 4.35e-08

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 53.99  E-value: 4.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGrmatrrveadgtMLRFdhGAqyftardPRFveqvaRWEREgvVAR 89
Cdd:COG0493   124 VAVVGSGPAGLAAAYQLARAGHEVTVFEALDKPGG------------LLRY--GI-------PEF-----RLPKD--VLD 175

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2569584920  90 WDVAGedawvgtpamnapIKAMAGRhdVQFGTRI------EQLLRDgdrwqldgdgapdrrFDAVVVALPAEQAGPL 160
Cdd:COG0493   176 REIEL-------------IEALGVE--FRTNVEVgkditlDELLEE---------------FDAVFLATGAGKPRDL 222
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 2-46 4.54e-08

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 54.11  E-value: 4.54e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2569584920   2 PEADGAMQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRM 46
Cdd:PRK12771  132 PAPDTGKRVAVIGGGPAGLSAAYHLRRMGHAVTIFEAGPKLGGMM 176
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 10-44 6.66e-08

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 53.64  E-value: 6.66e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGG 44
Cdd:PRK11749  143 VAVIGAGPAGLTAAHRLARKGYDVTIFEARDKAGG 177
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
8-63 7.10e-08

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 53.20  E-value: 7.10e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALgHDVALFDKGRGPGGRMATRRVEADGTMLRFDHG 63
Cdd:COG2907     4 MRIAVIGSGISGLTAAWLLSRR-HDVTLFEANDRLGGHTHTVDVDLDGRTVPVDTG 58
PRK07233 PRK07233
hypothetical protein; Provisional
 10-62 6.75e-07

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 50.27  E-value: 6.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATrrVEADGTML-RFDH 62
Cdd:PRK07233    2 IAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGLAAS--FEFGGLPIeRFYH 53
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 12-76 7.79e-07

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 50.35  E-value: 7.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569584920  12 IVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRmaTRRVEADGtmLRFDHGAQYFTarDPRFVE 76
Cdd:TIGR02734   3 VIGAGFGGLALAIRLAAAGIPVTVVEQRDKPGGR--AGVLEDDG--FRFDTGPTVIT--MPEALE 61
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 8-47 1.22e-06

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 49.24  E-value: 1.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDKGRG-PGGRMA 47
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGTcPYGGCV 41
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 10-47 2.55e-06

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 48.45  E-value: 2.55e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMA 47
Cdd:PRK12770   21 VAIIGAGPAGLAAAGYLACLGYEVHVYDKLPEPGGLML 58
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 39-315 2.77e-06

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 48.64  E-value: 2.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  39 GRGPGGRMATRRVEADGTMLRFDHGAQYFTARDPRFVEQVA---RWEREGvvarwdvAGEDAWVGTPAMNAPIKAMA--- 112
Cdd:pfam01593 144 RRGPGDVEVWDRLIDPELFAALPFASGAFAGDPSELSAGLAlplLWALLG-------EGGSLLLPRGGLGALPDALAaql 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920 113 GRHDVQFGTRIEQLLRDGDRWQLDGDGAPDRRFDAVVVALPA------EQAGPLLQPHASAMGNLaDATSSDpcwTVMAA 186
Cdd:pfam01593 217 LGGDVRLNTRVRSIDREGDGVTVTLTDGEVIEADAVIVTVPLgvlkriLFTPPLPPEKARAIRNL-GYGPVN---KVHLE 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920 187 FEQRlPSEQDSIRHHGAIGWAAR----------NNAKPGRGSAE-CWVVQASPDWSRAHLEDEATAveTALLDQLADAIG 255
Cdd:pfam01593 293 FDRK-FWPDLGLLGLLSELLTGLgtafswltfpNRAPPGKGLLLlVYVGPGDRARELEGLSDEELL--QAVLRDLRKLFG 369

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2569584920 256 APLPPRLAISAHRW---RFARSG------SAGEEALWDAQQ----RIGVCGDWLIGP---RVEAAYLSGLLLAETV 315
Cdd:pfam01593 370 EEAPEPLRVLVSDWhtdPWPRGSyslpqyGPGHDDYRPLARtpdpGLFFAGEHTSTGypgTVEGAIESGRRAARAV 445
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 10-151 3.07e-06

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 48.16  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGG------------------RMATRRVEADGTMLRFDHGAQY----- 66
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSgasgrnaglihpglrylePSELARLALEALDLWEELEEELgidcg 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  67 ----------FTARDPRFVEQVARWEREGVVARW--------------DVAG-----EDAWVGTPAMNAPIKAMAGRHDV 117
Cdd:pfam01266  82 frrcgvlvlaRDEEEEALEKLLAALRRLGVPAELldaeelrelepllpGLRGglfypDGGHVDPARLLRALARAAEALGV 161

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2569584920 118 QF--GTRIEQLLRDGDRWQLDGDGapdrRFDAVVVA 151
Cdd:pfam01266 162 RIieGTEVTGIEEEGGVWGVVTTG----EADAVVNA 193
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 10-46 4.21e-06

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 48.19  E-value: 4.21e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRM 46
Cdd:PRK12814  196 VAIIGAGPAGLTAAYYLLRKGHDVTIFDANEQAGGMM 232
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 10-68 4.45e-06

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 48.06  E-value: 4.45e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVEADGTMLRFDHGAQYFT 68
Cdd:PLN02328  241 VVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRVKTMKMKGDGVVAAADLGGSVLT 299
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 8-151 5.54e-06

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 47.24  E-value: 5.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDK-------GRG----PGGRMATRRVEADGTMLRfdHGAQYFTARdprfve 76
Cdd:COG0654     4 TDVLIVGGGPAGLALALALARAGIRVTVVERappprpdGRGialsPRSLELLRRLGLWDRLLA--RGAPIRGIR------ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  77 qVARWEREGVVARWDVAGEDAWVGTPAMNAPI------KAMAGRHDVQFGTRIEQLLRDGDRWQLDGDGAPDRRFDAVVV 150
Cdd:COG0654    76 -VRDGSDGRVLARFDAAETGLPAGLVVPRADLeralleAARALGVELRFGTEVTGLEQDADGVTVTLADGRTLRADLVVG 154


                  .
gi 2569584920 151 A 151
Cdd:COG0654   155 A 155
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 17-80 5.66e-06

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 47.49  E-value: 5.66e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2569584920  17 MAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVeaDGtmLRFDHGAQYFTARDPRFVEQVAR 80
Cdd:pfam01593   1 LAGLAAARELLRAGHDVTVLEARDRVGGRIRTVRD--DG--FLIELGAMWFHGAQPPLLALLKE 60
PLN03000 PLN03000
amine oxidase
 1-68 1.35e-05

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 46.55  E-value: 1.35e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2569584920   1 MPEADGAMQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVEADGTMLRFDHGAQYFT 68
Cdd:PLN03000  178 FPAQSSKSSVVIVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKMEANRVGAAADLGGSVLT 245
HI0933_like pfam03486
HI0933-like protein;
9-43 2.35e-05

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 45.65  E-value: 2.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2569584920   9 QIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPG 43
Cdd:pfam03486   2 DVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLG 36
PRK12831 PRK12831
putative oxidoreductase; Provisional
 2-44 2.62e-05

putative oxidoreductase; Provisional


Pssm-ID: 183780 [Multi-domain]  Cd Length: 464  Bit Score: 45.39  E-value: 2.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2569584920   2 PEADGAMQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGG 44
Cdd:PRK12831  135 TEEKKGKKVAVIGSGPAGLTCAGDLAKMGYDVTIFEALHEPGG 177
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
15-151 5.15e-05

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 44.19  E-value: 5.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  15 AGMAGLSCATRLAALGHDVALFDKGRGPGGrmatrRVEADGTMLR-------FDHGA--------QYFTARDPRFVEQVA 79
Cdd:COG0644     1 AGPAGSAAARRLARAGLSVLLLEKGSFPGD-----KICGGGLLPRaleelepLGLDEplerpvrgARFYSPGGKSVELPP 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2569584920  80 RWEREGVVARWDVageDAWVGTPAMNAPIkamagrhDVQFGTRIEQLLRDGDRWQLDGDGAPDRRFDAVVVA 151
Cdd:COG0644    76 GRGGGYVVDRARF---DRWLAEQAEEAGA-------EVRTGTRVTDVLRDDGRVVVRTGDGEEIRADYVVDA 137
PRK06753 PRK06753
hypothetical protein; Provisional
 8-38 6.38e-05

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 44.29  E-value: 6.38e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDK 38
Cdd:PRK06753    1 MKIAIIGAGIGGLTAAALLQEQGHEVKVFEK 31
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 10-44 6.73e-05

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 44.40  E-value: 6.73e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRgPGG 44
Cdd:PRK06292    6 VIVIGAGPAGYVAARRAAKLGKKVALIEKGP-LGG 39
PRK12778 PRK12778
bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate ...
 8-44 7.42e-05

bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate synthase;


Pssm-ID: 237200 [Multi-domain]  Cd Length: 752  Bit Score: 44.35  E-value: 7.42e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGG 44
Cdd:PRK12778  432 KKVAVIGSGPAGLSFAGDLAKRGYDVTVFEALHEIGG 468
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
11-43 7.55e-05

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 43.89  E-value: 7.55e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2569584920  11 AIVGAGMAGLSCATRLAALGHDVALFDKGRGPG 43
Cdd:COG2081     1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVG 33
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 8-38 1.03e-04

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 43.75  E-value: 1.03e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDK 38
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLADLGHDVTGVDI 31
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
8-44 1.08e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 43.36  E-value: 1.08e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGG 44
Cdd:COG0665     3 ADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGSG 39
PLN02529 PLN02529
lysine-specific histone demethylase 1
 1-68 1.30e-04

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 43.73  E-value: 1.30e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2569584920   1 MPEADGAMQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATRRVEADGTMLRFDHGAQYFT 68
Cdd:PLN02529  154 IPEEGTEGSVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYTQKMGRKGQFAAVDLGGSVIT 221
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 8-72 1.32e-04

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 43.30  E-value: 1.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2569584920   8 MQIAIVGAGMAGLSCATRL--AALGHDVALFDKGRGPGGRMATRRVeaDGtmLRFDHGAQYFTARDP 72
Cdd:PRK11883    1 KKVAIIGGGITGLSAAYRLhkKGPDADITLLEASDRLGGKIQTVRK--DG--FPIELGPESFLARKP 63
PLN02487 PLN02487
zeta-carotene desaturase
 2-48 2.43e-04

zeta-carotene desaturase


Pssm-ID: 215268 [Multi-domain]  Cd Length: 569  Bit Score: 42.48  E-value: 2.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2569584920   2 PEADGA--MQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMAT 48
Cdd:PLN02487   68 PEAYKGpkLKVAIIGAGLAGMSTAVELLDQGHEVDIYESRPFIGGKVGS 116
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 10-151 3.27e-04

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 42.14  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPG----------------------GRM-------ATRRVEA-DGTMLR 59
Cdd:PRK01747  263 AAIIGGGIAGAALALALARRGWQVTLYEADEAPAqgasgnrqgalypllskddnalSRFfraaflfARRFYDAlPAAGVA 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  60 FDHGA----QYftARDP-------------------RFVEQVARWEREGvvarWDVA------GEDAWVGTPAMNAPIKA 110
Cdd:PRK01747  343 FDHDWcgvlQL--AWDEksaekiakmlalglpaelaRALDAEEAEELAG----LPVPcggifyPQGGWLCPAELCRALLA 416

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2569584920 111 MAGRH-DVQFGTRIEQLLRDGDRWQLDGDGAPDRRFDAVVVA 151
Cdd:PRK01747  417 LAGQQlTIHFGHEVARLEREDDGWQLDFAGGTLASAPVVVLA 458
PRK13984 PRK13984
putative oxidoreductase; Provisional
 9-46 3.30e-04

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 42.06  E-value: 3.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2569584920   9 QIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRM 46
Cdd:PRK13984  285 KVAIVGSGPAGLSAAYFLATMGYEVTVYESLSKPGGVM 322
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
 8-38 3.83e-04

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 40.69  E-value: 3.83e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDK 38
Cdd:pfam03721   1 MKISVIGLGYVGLPTAACLAEIGHDVIGVDI 31
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
10-47 8.58e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 41.00  E-value: 8.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMA 47
Cdd:COG1148   143 ALVIGGGIAGMTAALELAEQGYEVYLVEKEPELGGRAA 180
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 10-44 9.01e-04

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 40.84  E-value: 9.01e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRgPGG 44
Cdd:COG1249     6 LVVIGAGPGGYVAAIRAAQLGLKVALVEKGR-LGG 39
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 10-44 1.09e-03

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 40.35  E-value: 1.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGG 44
Cdd:pfam00890   2 VLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGG 36
PRK06370 PRK06370
FAD-containing oxidoreductase;
12-40 1.44e-03

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 40.19  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*....
gi 2569584920  12 IVGAGMAGLSCATRLAALGHDVALFDKGR 40
Cdd:PRK06370   10 VIGAGQAGPPLAARAAGLGMKVALIERGL 38
PRK05329 PRK05329
glycerol-3-phosphate dehydrogenase subunit GlpB;
10-41 1.46e-03

glycerol-3-phosphate dehydrogenase subunit GlpB;


Pssm-ID: 235412  Cd Length: 422  Bit Score: 39.83  E-value: 1.46e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRG 41
Cdd:PRK05329    5 VLVIGGGLAGLTAALAAAEAGKRVALVAKGQG 36
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 10-39 1.56e-03

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 39.88  E-value: 1.56e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKG 39
Cdd:TIGR01988   2 IVIVGGGMVGLALALALARSGLKVALIEAT 31
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
10-48 1.83e-03

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 39.33  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2569584920  10 IAIVGAGMAGLSCATRLAALGHDVALFDKGRgPGGRMAT 48
Cdd:COG0492     3 VVIIGAGPAGLTAAIYAARAGLKTLVIEGGE-PGGQLAT 40
PRK12921 PRK12921
oxidoreductase;
8-63 2.77e-03

oxidoreductase;


Pssm-ID: 183829 [Multi-domain]  Cd Length: 305  Bit Score: 38.69  E-value: 2.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDKGRgpgGRMATRRveaDGTMLRFDHG 63
Cdd:PRK12921    1 MRIAVVGAGAVGGTFGGRLLEAGRDVTFLVRPK---RAKALRE---RGLVIRSDHG 50
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 9-42 3.38e-03

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 38.85  E-value: 3.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2569584920   9 QIAIVGAGMAGLSCATRLAALGHDVALFDKGRGP 42
Cdd:PRK12409    3 HIAVIGAGITGVTTAYALAQRGYQVTVFDRHRYA 36
PRK07208 PRK07208
hypothetical protein; Provisional
 9-76 3.99e-03

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 38.72  E-value: 3.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2569584920   9 QIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPGGRMATrrVEADGTmlRFDHGAQYFTARDPRFVE 76
Cdd:PRK07208    6 SVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGGISRT--VTYKGN--RFDIGGHRFFSKSPEVMD 69
PRK00711 PRK00711
D-amino acid dehydrogenase;
8-43 5.14e-03

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 38.24  E-value: 5.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2569584920   8 MQIAIVGAGMAGLSCATRLAALGHDVALFDKGRGPG 43
Cdd:PRK00711    1 MRVVVLGSGVIGVTSAWYLAQAGHEVTVIDRQPGPA 36
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
11-152 7.66e-03

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 36.49  E-value: 7.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  11 AIVGAGMAGLSCATRLAAL----GHDVALFDKgRGPGGRMATRRVEADGTMLRFDHGA-QYFTARDPRFVeqvaRW--ER 83
Cdd:pfam13454   1 AIVGGGPSGLALLERLLARapkrPLEITLFDP-SPPGAGGVYRTDQSPEHLLNVPASRmSLFPDDPPHFL----EWlrAR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569584920  84 EGVVARWDVAGED-----------AWVGTPAmnapIKAMAGRHDVQF-GTRIEQLLRDGDRWQLDGDGAPDRRFDAVVVA 151
Cdd:pfam13454  76 GALDEAPGLDPDDfppralygrylRDRFEEA----LARAPAGVTVRVhRARVTDLRPRGDGYRVLLADGRTLAADAVVLA 151


                  .
gi 2569584920 152 L 152
Cdd:pfam13454 152 T 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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