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Conserved domains on  [gi|2573224370|ref|WP_308353257|]
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MULTISPECIES: OapA family protein [Serratia]

Protein Classification

OapA family protein( domain architecture ID 11459647)

opacity-associated protein OapA family protein similar to Escherichia coli cell division protein YtfB whose function is related to the generation of a transient cell wall structure

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 73-223 5.49e-44

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 152.51  E-value: 5.49e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2573224370  73 MEPLPYFHRRWVLIFGIILLLALLWPySPERQPFPVSQQETSVPLQADLQNGGGATSANEPTPAGNWQRYQIQPGQTLAQ 152
Cdd:COG3061     4 MNPLPRKHRRLLGLLSALLLLALLLP-SPDASASRVSQPLVPLALTAEADAPAAAAPAAPAAPEGEWQEYTVQSGDTLSQ 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2573224370 153 LFRDNNLPVNEVFAMAQVEGGDKPLSNMKAGQEVRIERDANGVINALSVTTVDNSQALFRRQADGSYRRER 223
Cdd:COG3061    83 IFRRLGLSASDLYALLAAEGDAKPLSRLKPGQELRFQLDADGQLQALRYEVSRLETLLFTRQGDGFQRKRV 153
 
Name Accession Description Interval E-value
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 73-223 5.49e-44

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 152.51  E-value: 5.49e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2573224370  73 MEPLPYFHRRWVLIFGIILLLALLWPySPERQPFPVSQQETSVPLQADLQNGGGATSANEPTPAGNWQRYQIQPGQTLAQ 152
Cdd:COG3061     4 MNPLPRKHRRLLGLLSALLLLALLLP-SPDASASRVSQPLVPLALTAEADAPAAAAPAAPAAPEGEWQEYTVQSGDTLSQ 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2573224370 153 LFRDNNLPVNEVFAMAQVEGGDKPLSNMKAGQEVRIERDANGVINALSVTTVDNSQALFRRQADGSYRRER 223
Cdd:COG3061    83 IFRRLGLSASDLYALLAAEGDAKPLSRLKPGQELRFQLDADGQLQALRYEVSRLETLLFTRQGDGFQRKRV 153
OapA pfam04225
Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the ...
 138-223 3.66e-38

Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. The OapA domain has been shown to bind to peptidoglycan in the E. coli protein YtfB. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links. The OapA domain is distantly related to pfam01476.


Pssm-ID: 427799 [Multi-domain]  Cd Length: 85  Bit Score: 127.47  E-value: 3.66e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2573224370 138 NWQRYQIQPGQTLAQLFRDNNLPVNEVFAMAQVEGGDKPLSNMKAGQEVRIERDANGVINALSVTTvDNSQALFRRQADG 217
Cdd:pfam04225   1 NWKTYTVPKGDTLAQLFRDNNLPISDVNAMAKVEGADKPLSNIKSGQLVRIKLNAQGRVDELQIEN-GAKSVMFFRQSDG 79


                  ....*.
gi 2573224370 218 SYRRER 223
Cdd:pfam04225  80 SFGRKK 85
 
Name Accession Description Interval E-value
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 73-223 5.49e-44

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 152.51  E-value: 5.49e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2573224370  73 MEPLPYFHRRWVLIFGIILLLALLWPySPERQPFPVSQQETSVPLQADLQNGGGATSANEPTPAGNWQRYQIQPGQTLAQ 152
Cdd:COG3061     4 MNPLPRKHRRLLGLLSALLLLALLLP-SPDASASRVSQPLVPLALTAEADAPAAAAPAAPAAPEGEWQEYTVQSGDTLSQ 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2573224370 153 LFRDNNLPVNEVFAMAQVEGGDKPLSNMKAGQEVRIERDANGVINALSVTTVDNSQALFRRQADGSYRRER 223
Cdd:COG3061    83 IFRRLGLSASDLYALLAAEGDAKPLSRLKPGQELRFQLDADGQLQALRYEVSRLETLLFTRQGDGFQRKRV 153
OapA pfam04225
Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the ...
 138-223 3.66e-38

Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. The OapA domain has been shown to bind to peptidoglycan in the E. coli protein YtfB. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links. The OapA domain is distantly related to pfam01476.


Pssm-ID: 427799 [Multi-domain]  Cd Length: 85  Bit Score: 127.47  E-value: 3.66e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2573224370 138 NWQRYQIQPGQTLAQLFRDNNLPVNEVFAMAQVEGGDKPLSNMKAGQEVRIERDANGVINALSVTTvDNSQALFRRQADG 217
Cdd:pfam04225   1 NWKTYTVPKGDTLAQLFRDNNLPISDVNAMAKVEGADKPLSNIKSGQLVRIKLNAQGRVDELQIEN-GAKSVMFFRQSDG 79


                  ....*.
gi 2573224370 218 SYRRER 223
Cdd:pfam04225  80 SFGRKK 85
OapA_N pfam08525
Opacity-associated protein A N-terminal motif; This family includes the Haemophilus influenzae ...
 72-98 4.74e-06

Opacity-associated protein A N-terminal motif; This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. This motif occurs at the N-terminus of these proteins. It contains a conserved histidine followed by a run of hydrophobic residues.


Pssm-ID: 430054  Cd Length: 27  Bit Score: 41.92  E-value: 4.74e-06
                          10        20
                  ....*....|....*....|....*..
gi 2573224370  72 WMEPLPYFHRRWVLIFGIILLLALLWP 98
Cdd:pfam08525   1 LFKPLPKLHRRLLLALSLVVLILLLWP 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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