NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2582485817|ref|WP_311510520|]
View 

type II CAAX prenyl endopeptidase Rce1 family protein [Nocardiopsis sp. DSM 44743]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 171-262 6.45e-17

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 76.37  E-value: 6.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 171 AAIGVAVTGGLCAELLYRGLFI-VLVTSMGVplWIGAVLSVLLFAVAYLYQgWWGLVSASASGTLFVVLYLGTGSLWVPV 249
Cdd:COG1266     7 FLLVVVILAPIAEELLFRGYLLgRLRRRFGP--WLAILLSSLLFGLLHLPN-LLGFLPAFLLGLVLGLLYLRTGSLWVPI 83

                          90
                  ....*....|...
gi 2582485817 250 LVHIALNLRSLAF 262
Cdd:COG1266    84 LLHALNNLLALLL 96
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 265-659 1.40e-07

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.18  E-value: 1.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  265 AALREESYAYDEPYEDEPYDDPDSGSDETPDGAGHPIV--PALGAPPPFAPARDTLALGGAGYPGGAGAPVPGGPSPSLG 342
Cdd:PHA03307    14 AAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAavTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  343 DARPAPPAGEAGPYPAAPTWDAPAQGAPALGGAEPPPTEGNPSVRGPGAQPAGSWNTPAPGAPGFGGgeyRPGAHGAHGS 422
Cdd:PHA03307    94 TLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPA---AVASDAASSR 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  423 SGSAPLPgwgTPGQGTPSHGGGSSSGAGPSAGGAGAHPSAGTWNTPAPGAPGLGGGDYRPGAHGADASSWNSGAQSGPHP 502
Cdd:PHA03307   171 QAALPLS---SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGC 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  503 SAGTWNTPARGAPGLGGDEYRPGAHRADGSSGSAPLPGR-GTPGQGTPSFGGTGYPDGPGYGTRPPAHGDPSGRPLGAQA 581
Cdd:PHA03307   248 GWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASsSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSS 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  582 DPAPGGDASRASGPYPAAP--AWGTPAQGAPSFDGSSPTDAATWGTGTWNGPRPDAgsRNTPARGGPVPGGAEDRAGTPP 659
Cdd:PHA03307   328 STSSSSESSRGAAVSPGPSpsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAG--RPTRRRARAAVAGRARRRDATG 405
 
Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 171-262 6.45e-17

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 76.37  E-value: 6.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 171 AAIGVAVTGGLCAELLYRGLFI-VLVTSMGVplWIGAVLSVLLFAVAYLYQgWWGLVSASASGTLFVVLYLGTGSLWVPV 249
Cdd:COG1266     7 FLLVVVILAPIAEELLFRGYLLgRLRRRFGP--WLAILLSSLLFGLLHLPN-LLGFLPAFLLGLVLGLLYLRTGSLWVPI 83

                          90
                  ....*....|...
gi 2582485817 250 LVHIALNLRSLAF 262
Cdd:COG1266    84 LLHALNNLLALLL 96
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 171-257 1.12e-16

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 75.67  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 171 AAIGVAVTGGLCAELLYRGLFIVLVTSMGvPLWIGAVLSVLLFAVAYLYQGWWGLVSASASGTLFVVLYLGTGSLWVPVL 250
Cdd:pfam02517   6 LLLLLALLAPIGEELLFRGYLLPRLRRRL-WPVLAILISSLLFGLAHLPNGPQLFLLAFLLGLILGYLYLRTGSLWAAIL 84


                  ....*..
gi 2582485817 251 VHIALNL 257
Cdd:pfam02517  85 LHALNNL 91
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 265-659 1.40e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.18  E-value: 1.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  265 AALREESYAYDEPYEDEPYDDPDSGSDETPDGAGHPIV--PALGAPPPFAPARDTLALGGAGYPGGAGAPVPGGPSPSLG 342
Cdd:PHA03307    14 AAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAavTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  343 DARPAPPAGEAGPYPAAPTWDAPAQGAPALGGAEPPPTEGNPSVRGPGAQPAGSWNTPAPGAPGFGGgeyRPGAHGAHGS 422
Cdd:PHA03307    94 TLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPA---AVASDAASSR 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  423 SGSAPLPgwgTPGQGTPSHGGGSSSGAGPSAGGAGAHPSAGTWNTPAPGAPGLGGGDYRPGAHGADASSWNSGAQSGPHP 502
Cdd:PHA03307   171 QAALPLS---SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGC 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  503 SAGTWNTPARGAPGLGGDEYRPGAHRADGSSGSAPLPGR-GTPGQGTPSFGGTGYPDGPGYGTRPPAHGDPSGRPLGAQA 581
Cdd:PHA03307   248 GWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASsSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSS 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  582 DPAPGGDASRASGPYPAAP--AWGTPAQGAPSFDGSSPTDAATWGTGTWNGPRPDAgsRNTPARGGPVPGGAEDRAGTPP 659
Cdd:PHA03307   328 STSSSSESSRGAAVSPGPSpsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAG--RPTRRRARAAVAGRARRRDATG 405
 
Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 171-262 6.45e-17

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 76.37  E-value: 6.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 171 AAIGVAVTGGLCAELLYRGLFI-VLVTSMGVplWIGAVLSVLLFAVAYLYQgWWGLVSASASGTLFVVLYLGTGSLWVPV 249
Cdd:COG1266     7 FLLVVVILAPIAEELLFRGYLLgRLRRRFGP--WLAILLSSLLFGLLHLPN-LLGFLPAFLLGLVLGLLYLRTGSLWVPI 83

                          90
                  ....*....|...
gi 2582485817 250 LVHIALNLRSLAF 262
Cdd:COG1266    84 LLHALNNLLALLL 96
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 171-257 1.12e-16

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 75.67  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 171 AAIGVAVTGGLCAELLYRGLFIVLVTSMGvPLWIGAVLSVLLFAVAYLYQGWWGLVSASASGTLFVVLYLGTGSLWVPVL 250
Cdd:pfam02517   6 LLLLLALLAPIGEELLFRGYLLPRLRRRL-WPVLAILISSLLFGLAHLPNGPQLFLLAFLLGLILGYLYLRTGSLWAAIL 84


                  ....*..
gi 2582485817 251 VHIALNL 257
Cdd:pfam02517  85 LHALNNL 91
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 265-659 1.40e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.18  E-value: 1.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  265 AALREESYAYDEPYEDEPYDDPDSGSDETPDGAGHPIV--PALGAPPPFAPARDTLALGGAGYPGGAGAPVPGGPSPSLG 342
Cdd:PHA03307    14 AAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAavTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  343 DARPAPPAGEAGPYPAAPTWDAPAQGAPALGGAEPPPTEGNPSVRGPGAQPAGSWNTPAPGAPGFGGgeyRPGAHGAHGS 422
Cdd:PHA03307    94 TLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPA---AVASDAASSR 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  423 SGSAPLPgwgTPGQGTPSHGGGSSSGAGPSAGGAGAHPSAGTWNTPAPGAPGLGGGDYRPGAHGADASSWNSGAQSGPHP 502
Cdd:PHA03307   171 QAALPLS---SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGC 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  503 SAGTWNTPARGAPGLGGDEYRPGAHRADGSSGSAPLPGR-GTPGQGTPSFGGTGYPDGPGYGTRPPAHGDPSGRPLGAQA 581
Cdd:PHA03307   248 GWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASsSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSS 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  582 DPAPGGDASRASGPYPAAP--AWGTPAQGAPSFDGSSPTDAATWGTGTWNGPRPDAgsRNTPARGGPVPGGAEDRAGTPP 659
Cdd:PHA03307   328 STSSSSESSRGAAVSPGPSpsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAG--RPTRRRARAAVAGRARRRDATG 405
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 496-677 5.82e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 53.07  E-value: 5.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 496 AQSGPHPSAGTWNTPARGAPGLGGDEyrpGAHRADGSSGSAPLPGRGTPGQGTPSFGGTGYPDGPGYGTRPPAH---GDP 572
Cdd:PRK07764  586 AVVGPAPGAAGGEGPPAPASSGPPEE---AARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHvavPDA 662

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 573 SGRPLGAQADPAPGGDASRASGPYPAAPAWGTPAQGAPSFDGSSPTDAATWGTGTWNGPRPDAGSRNTPARGGPVPGGAE 652
Cdd:PRK07764  663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLP 742

                         170       180
                  ....*....|....*....|....*
gi 2582485817 653 DRAGTPPWDEAGTGSHGGPRHAEPR 677
Cdd:PRK07764  743 PEPDDPPDPAGAPAQPPPPPAPAPA 767
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 495-659 1.54e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.44  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 495 GAQSGPHPSAGTWNTPARGAPGLGGDEYRPGAHRADGSSGSAP-LPGRGTPGQGTPSFGGTGYPDGPGYGTRPPAHGDPS 573
Cdd:PRK07764  612 AARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPkHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPA 691

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 574 GRPLGAQADPAPGGDASRASGPYPAAPAWGTPAQGAPSFDGSSPTDAATWGTGTWNGPRPDAGSRNTPARGGPVPGGAED 653
Cdd:PRK07764  692 APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPA 771


                  ....*.
gi 2582485817 654 RAGTPP 659
Cdd:PRK07764  772 AAPPPS 777
PHA03247 PHA03247
large tegument protein UL36; Provisional
 481-659 4.41e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 4.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  481 RPGAHGADASSWNSGAQSGPHPSAGTWNTPARGAPGLGGDEY---RPGAHRADGSSGSAPLPGRGTPGQGTPSFGGTGYP 557
Cdd:PHA03247  2597 RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQA 2676

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  558 DGPGYGTRPPAHGDPSGrPLGAQADPAPGGDASrASGPYPAAPAWGTPAQGAPSFDGSSPTDAATWGTGTWNGPRPDAGS 637
Cdd:PHA03247  2677 SSPPQRPRRRAARPTVG-SLTSLADPPPPPPTP-EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP 2754

                          170       180
                   ....*....|....*....|....*.
gi 2582485817  638 RNTPAR----GGPVPGGAEDRAGTPP 659
Cdd:PHA03247  2755 ARPARPpttaGPPAPAPPAAPAAGPP 2780
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 415-613 6.40e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.52  E-value: 6.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 415 GAHGAHGSSGSAPLPGWGTPGQGTPSHGGGSSSGAGPSAGGAGAHPSAGTWNTPAPGAPGLGGGDYRPGAHGADASSWNS 494
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 495 GAQSG-PHPSAGTWNTPARGAPGLGGDEYRPGAHRADGSSGSAPLPGRGTPGQGTPSfGGTGYPDGPGYGTRPPAHGDPS 573
Cdd:PRK07764  670 PAKAGgAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQ-GASAPSPAADDPVPLPPEPDDP 748

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2582485817 574 GRPLGAQADPAPGGDASRASGPyPAAPAWGTPAQGAPSFD 613
Cdd:PRK07764  749 PDPAGAPAQPPPPPAPAPAAAP-AAAPPPSPPSEEEEMAE 787
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 292-676 2.26e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 292 ETPDGAGHPIVPALGAPPPfAPARDTLALGGAGYPGGAGAPVPGGPSPSLGDARPAPpAGEAGPYPAAPTWDAPAQGAPA 371
Cdd:PRK07764  413 AAAAPAAAAAPAPAAAPQP-APAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAP-APAAAPEPTAAPAPAPPAAPAP 490

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 372 LGGAEPPPTEGNPSVRGPGAQPAGSWNT---PAPGAPGFGGGEYRPGAHgAHGSSGSAPLPGWGTPGQGTPSHGGGSS-- 446
Cdd:PRK07764  491 AAAPAAPAAPAAPAGADDAATLRERWPEilaAVPKRSRKTWAILLPEAT-VLGVRGDTLVLGFSTGGLARRFASPGNAev 569

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 447 ----------SGAGPSAGGAGAHPSAGTWNTPAPGAPGLGGGDYRPGAHGADASSWNSGAQSGPHPSAGTWNTPARGAPg 516
Cdd:PRK07764  570 lvtalaeelgGDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVA- 648

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 517 lggdeyrPGAHRADGSSGSAPLPGRGTPGQGTPSFGGTGYPDGPGYGTRPPAHGDPSGRPLGAQADPAPGGDASRASGPY 596
Cdd:PRK07764  649 -------APEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQP 721

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 597 PAAPAWGTPAQGAPSFDGSSPTDAATWGTGTWNGPRPDAGSRNTPARGGPVPGGAEDRAGTPPWDEAGTGSHGGPRHAEP 676
Cdd:PRK07764  722 PQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDA 801
PHA03247 PHA03247
large tegument protein UL36; Provisional
 263-653 7.65e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 7.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  263 PPAALREESYAYDEPYEDEPYDDPDSGSDETPDGAGHPIVPALGAPPPFAP----ARDTLALGGAGYPGGAGAPVPGGPS 338
Cdd:PHA03247  2633 PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPrrraARPTVGSLTSLADPPPPPPTPEPAP 2712

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  339 PSLGDARPAPPAGEAGPYPAAPTWDAPAQGAPALGGAEPppteGNPSVRGPGAQPAGSWNTPAPGAPGFGGGEYRPGAHG 418
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP----GGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAV 2788

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  419 AHGSSGSAPLPGWGTPGQGTPSHGGGSSSGAGPSAGGAGAHPSAGTWNTPAPGAPGLGGGDYRPGAhgadasswnSGAQS 498
Cdd:PHA03247  2789 ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG---------SVAPG 2859

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  499 GPHPSAGtwntPARGAPGLGGDEYRPGAHRAdgssgSAPLPGRGTPGQGTPsfggtgyPDGPGYGTRPPAHGDPSGRPLG 578
Cdd:PHA03247  2860 GDVRRRP----PSRSPAAKPAAPARPPVRRL-----ARPAVSRSTESFALP-------PDQPERPPQPQAPPPPQPQPQP 2923

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2582485817  579 AQADPAPGGDASRASGPYPAAPAWGTPAQGAPSFDGSSPTDAATwGTGTWNGPR----PDAGSRNTPARGGPVPGGAED 653
Cdd:PHA03247  2924 PPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL-VPGRVAVPRfrvpQPAPSREAPASSTPPLTGHSL 3001
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 512-638 9.18e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 9.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 512 RGAPGLGGDEY----RPGAHRADGSSGSAPLPGRGTPGQGTPSFGGTGYPDGPGYGTRPPAHGDPSGRPLGAQADPAPGG 587
Cdd:PRK07764  383 RRLGVAGGAGApaaaAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAP 462

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2582485817 588 DASRASGPYPAAPAWGTPAQGAPSFDGSSPTDAATWGTGTWNGPRPDAGSR 638
Cdd:PRK07764  463 SAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLR 513
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 520-646 1.08e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 42.36  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 520 DEYRPGAHRADGSSGSApLPGRGTPGQGTPSFGGTGYPDGpgygTRPPAHGDPSGrplGAQADPAPGgDASRASGPY--- 596
Cdd:PRK14959  369 ESLRPSGGGASAPSGSA-AEGPASGGAATIPTPGTQGPQG----TAPAAGMTPSS---AAPATPAPS-AAPSPRVPWdda 439

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2582485817 597 -PAAPAWGTPAQGAPSFDGSSPTDAATWGTGTWNGPRPDAGSRNTPARGGP 646
Cdd:PRK14959  440 pPAPPRSGIPPRPAPRMPEASPVPGAPDSVASASDAPPTLGDPSDTAEHTP 490
PHA03247 PHA03247
large tegument protein UL36; Provisional
 261-658 1.63e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  261 AFPPAALREESYAYDEPYEDEPYDDPDSGSDETPDGAGHPIVPA-------------------------------LGAPP 309
Cdd:PHA03247  2473 LFPGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLApailpdepvgepvhprmltwirgleelasddAGDPP 2552

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  310 PFAPARDTLALGGAGYPGGAGAPVPGGPSPSLGDARP-APPAGEAGPYPAAPTWDAPAQGAPALGGAEPPPTEGNPSVRG 388
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPdAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  389 PGAQPAGSWNTPAPGAPGFGGGEYRPG--------AHGAHGSSGSAPLPGWGTPGQGTPSHGGGSSSGAGPSAGGAGAHP 460
Cdd:PHA03247  2633 PAANEPDPHPPPTVPPPERPRDDPAPGrvsrprraRRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP 2712

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  461 SAGTWNTPAPGAPGlgggdyrpgahgadasswnSGAQSGPHPSAGTWNTPARGAPGLGGDEYRPGAhRADGSSGSAPLPG 540
Cdd:PHA03247  2713 HALVSATPLPPGPA-------------------AARQASPALPAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPP 2772

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  541 RGTPGqgtpsfggtgypdGPGYGTRPPAHGDPSGRPLGAQADPAPGGDASRASGPYPAAPAWGTPAQGAPsfdgsSPTDA 620
Cdd:PHA03247  2773 AAPAA-------------GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP-----PPTSA 2834

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2582485817  621 ATWGTGTWNGPRPDAgsrnTPARGGPVPGGAEDRAGTP 658
Cdd:PHA03247  2835 QPTAPPPPPGPPPPS----LPLGGSVAPGGDVRRRPPS 2868
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 368-621 1.83e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 368 GAPALGGAEPPPTEGNPSVRGPGAQPAGSwntpapgapgfGGGEYRPGAHGAHGSSGSAPLPGWGTPGQGtpshgggssS 447
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAP-----------AAPAAPAAPAPAGAAAAPAEASAAPAPGVA---------A 649

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 448 GAGPSAGGAGAHPSAGTWntpapgapglgggdyrpGAHGADASSWNSGAQSGPHPSAGTWNTPARGAPGLGGDEYRPGAH 527
Cdd:PRK07764  650 PEHHPKHVAVPDASDGGD-----------------GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG 712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 528 RADGSSGSAPLPGRGTPGQGTPSFGGTGYPDGPGYGTRPPAHGDPSGRPlGAQADPAPGGDASRASGPYPAAPAWGTPAQ 607
Cdd:PRK07764  713 QADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPP-PAPAPAAAPAAAPPPSPPSEEEEMAEDDAP 791

                         250
                  ....*....|....
gi 2582485817 608 GAPSFDGSSPTDAA 621
Cdd:PRK07764  792 SMDDEDRRDAEEVA 805
MgtE COG2239
Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism];
184-250 2.68e-03

Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism];


Pssm-ID: 441840 [Multi-domain]  Cd Length: 443  Bit Score: 40.82  E-value: 2.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2582485817 184 ELLYRGLFIVLVTSMGVPLWIGAVLSVLLFAVAYLYQGWW--GLVSASAsgtLFVVLYLGT--GSLwVPVL 250
Cdd:COG2239   341 EITLSDWWRVLLKELLVGLLNGLILGLVVGLVAYLWFGNPllGLVVGLA---LVINVLVAAlaGSL-LPLL 407
PHA03247 PHA03247
large tegument protein UL36; Provisional
 258-394 4.77e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 4.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817  258 RSLAFPPAALREESYAYDEPYEDEPYDDPDSGSDETPDGAGHPIVPALGAPPPFAPARDTLALGGAGYPGGAGAPVPGGP 337
Cdd:PHA03247  2684 RRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT 2763

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2582485817  338 SpslGDARPAPPAGEAGPYPAAPTWDAPAQGAPALGGAEPPPTEGNPSVRGPGAQPA 394
Cdd:PHA03247  2764 A---GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 344-719 8.65e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 8.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 344 ARPAPPAGEAGPYPAAPTWDAPAQGAPaLGGAEPPPTEGNPSVRGPGAQPAGSWNTPAPGAPGFGGGEYRPGAHGAhGSS 423
Cdd:PRK07764  360 ARMLLPSASDDERGLLARLERLERRLG-VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPA-PAP 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 424 GSAPLPGWGTPGQGTPSHGGGSSSG------AGPSAGGAGAHPSAGTWNTPAPGAPGLGGGDYRPGAHGADA----SSWN 493
Cdd:PRK07764  438 APAPPSPAGNAPAGGAPSPPPAAAPsaqpapAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAatlrERWP 517

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 494 SGAQSGPHPSAGTW----------------------NTPARGAPG---------------LGGD---EYRPGAHRADGSS 533
Cdd:PRK07764  518 EILAAVPKRSRKTWaillpeatvlgvrgdtlvlgfsTGGLARRFAspgnaevlvtalaeeLGGDwqvEAVVGPAPGAAGG 597

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 534 GSAPLPGRGTPGQGTPSFGGTGYPDGPGYGTRPPAHGDPSGRPLGAQADPAPGGDASRASG-PYPAAPAWGTPA---QGA 609
Cdd:PRK07764  598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAvPDASDGGDGWPAkagGAA 677

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2582485817 610 PSFDGSSPTDAATWGTGTWNGPRPDAGSRNT-PARGGPVPGGAEDRAGTPPWDEAGTGSHGGPRHAEPRWGTPGHGGPVP 688
Cdd:PRK07764  678 PAAPPPAPAPAAPAAPAGAAPAQPAPAPAATpPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQ 757

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2582485817 689 GGEGAQGGDLGDFLGGDAPAEEEGRRLYPDE 719
Cdd:PRK07764  758 PPPPPAPAPAAAPAAAPPPSPPSEEEEMAED 788
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH