|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
52-464 |
0e+00 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 543.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 52 IKASAHGITPRMFNRNALTVVEKLQRQGYEAYVVGGCLRDLLLGKKPKDFDVATNARPEQIQAVFqRQCRLVGRRFRLAH 131
Cdd:PRK11623 39 IPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLF-RNCRLVGRRFRLAH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 132 VMFGCEIIEVATFRAGHAEHHNEK-LAKQSEEGMLLRDNVYGTLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKNG 210
Cdd:PRK11623 118 VMFGPEIIEVATFRGHHEGNESDRnTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKEG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 211 KLRLIGDPVTRYQEDPVRMLRSIRFMAKLDMFLDKPSDAPIKSLAHLLKNIPPARLFEESLKLLQSGYGVKTYRLLRQYG 290
Cdd:PRK11623 198 VIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYH 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 291 LFEPLFPLLTPYFTEYEDSMTEKMILRALTSTDERVADKLPINPAFLFAAFFWYPLRERVEVLKNEGGLNNYDAYALASN 370
Cdd:PRK11623 278 LFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQKIAQESGLAYYDAFALAMN 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 371 DVLEQLCKSLAVPRRHTAVIREIWLLQLQFLKRTPKSVQRAIEQSKFRAGFDLLVMRAEIEGG-EAVELAAWWHEYQFSN 449
Cdd:PRK11623 358 DVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEVENNaELQRLAQWWGEFQVSA 437
|
410
....*....|....*
gi 2588609018 450 ESQRQDLVKELPSQP 464
Cdd:PRK11623 438 PPQQKGMLNELDDDP 452
|
|
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
52-458 |
2.13e-159 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 457.72 E-value: 2.13e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 52 IKASAHGITPRMFNRNALTVVEKLQRQGYEAYVVGGCLRDLLLGKKPKDFDVATNARPEQIQAVFqRQCRLVGRRFRLAH 131
Cdd:TIGR01942 2 IPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLF-RNSRIVGRRFRLVH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 132 VMFGCEIIEVATFRAGHAEHHNEklakqseEGMLLRDNVYGTLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKNGK 211
Cdd:TIGR01942 81 VSFGRQIIEVATFRSGHKSSVNA-------EGRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNRR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 212 LRLIGDPVTRYQEDPVRMLRSIRFMAKLDMFLDKPSDAPIKSLAHLLKNIPPARLFEESLKLLQSGYGVKTYRLLRQYGL 291
Cdd:TIGR01942 154 LRLIGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGYQL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 292 FEPLFPLLTPYFTEyEDSMTEKMILRALT-STDERVADKLPINPAFLFAAFFWYPLRERVEVLKNEgGLNNYDAYALASN 370
Cdd:TIGR01942 234 LEPLFPSVAYALRE-SPKFESAFTVQALVnDTDFRVKRDKPVTPAFLYAALLWPGLVFRVADAPDQ-GVMPYPAVFDAIR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 371 DVLEQLCKSLAVPRRHTAVIREIWLLQLQFLKRTPKSVQRAIEQSKFRAGFDLLVMRaEIEGGEAVELAAWWHEYQFSNE 450
Cdd:TIGR01942 312 DFVEEQCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLR-EVCGRENAVLGEWWTPYQLASE 390
|
....*...
gi 2588609018 451 SQRQDLVK 458
Cdd:TIGR01942 391 EERTEMTR 398
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
66-447 |
1.07e-116 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 348.34 E-value: 1.07e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 66 RNALTVVEKLQRQGYEAYVVGGCLRDLLLGKKPKDFDVATNARPEQIQAVFQRQ--CRLVGRRFRLAHVMFGCEIIEVAT 143
Cdd:COG0617 4 PNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRKAlrTVPVGRDFGTVTVVFGGEKIEVAT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 144 FRAGHAEHHneklakqseegmlLRD--NVYG-TLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKNGKLRLIGDPVT 220
Cdd:COG0617 84 ARTERYYGD-------------GRRpfVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDPEE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 221 RYQEDPVRMLRSIRFMAKLDMFLDKPSDAPIKSLAHLLKNIPPARLFEESLKLLQSGYGVKTYRLLRQYGLFEPLfpllt 300
Cdd:COG0617 151 RFREDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVL----- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 301 pyfteyedsmtekmilraltstdervadklpinpAFLFAAFFwYPLRERVEvlkNEGGLNNYDAYALASNDVLEQLCKSL 380
Cdd:COG0617 226 ----------------------------------ALRLAALL-HDLGKPAT---REDGLPTFHGHEEAGAELAEALLKRL 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2588609018 381 AVPRRHTAVIREIWLLQLQFL---KRTPKSVQRAIEQsKFRAGFDLLVMRAEIEGGEAVE------LAAWWHEYQF 447
Cdd:COG0617 268 RLPNRERKLVRELVELHLRFHglgELRDSAVRRLLER-GPEALEDLLLLRENGLEYPELQerlaelLEAAWRRFQP 342
|
|
| PolyA_pol |
pfam01743 |
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
82-213 |
2.58e-49 |
|
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.
Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 165.15 E-value: 2.58e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 82 AYVVGGCLRDLLLGKKPKDFDVATNARPEQIQAVFQR---QCRLVGRRFRLAHVMFGCEIIEVATFRAGHAE--HHNEKL 156
Cdd:pfam01743 1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRrriVHLLSGIEFGTIHVIFGNQILEVATFRIEFDEsdFRNPRS 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2588609018 157 AKQSeegmllrdnvyGTLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKNGKLR 213
Cdd:pfam01743 81 EEYT-----------GTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
67-209 |
4.32e-41 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 143.50 E-value: 4.32e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 67 NALTVVEKLQR-QGYEAYVVGGCLRDLLLGKKPKDFDVATNAR-PEQIQAVFQRQ-CRLVGR--RFRLAHVMFGCEIIEV 141
Cdd:cd05398 3 ELLKLLRELKKaLGYEAYLVGGAVRDLLLGRPPKDIDIATDADgPEFAEALFKKIgGRVVGLgeEFGTATVVINGLTIDV 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2588609018 142 ATFRAGhaehhneklaKQSEEGMLLRDNVYgTLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKN 209
Cdd:cd05398 83 ATLRTE----------TYTDPGRRPPVVGF-TIEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLEN 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
52-464 |
0e+00 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 543.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 52 IKASAHGITPRMFNRNALTVVEKLQRQGYEAYVVGGCLRDLLLGKKPKDFDVATNARPEQIQAVFqRQCRLVGRRFRLAH 131
Cdd:PRK11623 39 IPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLF-RNCRLVGRRFRLAH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 132 VMFGCEIIEVATFRAGHAEHHNEK-LAKQSEEGMLLRDNVYGTLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKNG 210
Cdd:PRK11623 118 VMFGPEIIEVATFRGHHEGNESDRnTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKEG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 211 KLRLIGDPVTRYQEDPVRMLRSIRFMAKLDMFLDKPSDAPIKSLAHLLKNIPPARLFEESLKLLQSGYGVKTYRLLRQYG 290
Cdd:PRK11623 198 VIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYH 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 291 LFEPLFPLLTPYFTEYEDSMTEKMILRALTSTDERVADKLPINPAFLFAAFFWYPLRERVEVLKNEGGLNNYDAYALASN 370
Cdd:PRK11623 278 LFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQKIAQESGLAYYDAFALAMN 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 371 DVLEQLCKSLAVPRRHTAVIREIWLLQLQFLKRTPKSVQRAIEQSKFRAGFDLLVMRAEIEGG-EAVELAAWWHEYQFSN 449
Cdd:PRK11623 358 DVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEVENNaELQRLAQWWGEFQVSA 437
|
410
....*....|....*
gi 2588609018 450 ESQRQDLVKELPSQP 464
Cdd:PRK11623 438 PPQQKGMLNELDDDP 452
|
|
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
52-458 |
2.13e-159 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 457.72 E-value: 2.13e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 52 IKASAHGITPRMFNRNALTVVEKLQRQGYEAYVVGGCLRDLLLGKKPKDFDVATNARPEQIQAVFqRQCRLVGRRFRLAH 131
Cdd:TIGR01942 2 IPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLF-RNSRIVGRRFRLVH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 132 VMFGCEIIEVATFRAGHAEHHNEklakqseEGMLLRDNVYGTLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKNGK 211
Cdd:TIGR01942 81 VSFGRQIIEVATFRSGHKSSVNA-------EGRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNRR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 212 LRLIGDPVTRYQEDPVRMLRSIRFMAKLDMFLDKPSDAPIKSLAHLLKNIPPARLFEESLKLLQSGYGVKTYRLLRQYGL 291
Cdd:TIGR01942 154 LRLIGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGYQL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 292 FEPLFPLLTPYFTEyEDSMTEKMILRALT-STDERVADKLPINPAFLFAAFFWYPLRERVEVLKNEgGLNNYDAYALASN 370
Cdd:TIGR01942 234 LEPLFPSVAYALRE-SPKFESAFTVQALVnDTDFRVKRDKPVTPAFLYAALLWPGLVFRVADAPDQ-GVMPYPAVFDAIR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 371 DVLEQLCKSLAVPRRHTAVIREIWLLQLQFLKRTPKSVQRAIEQSKFRAGFDLLVMRaEIEGGEAVELAAWWHEYQFSNE 450
Cdd:TIGR01942 312 DFVEEQCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLR-EVCGRENAVLGEWWTPYQLASE 390
|
....*...
gi 2588609018 451 SQRQDLVK 458
Cdd:TIGR01942 391 EERTEMTR 398
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
66-447 |
1.07e-116 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 348.34 E-value: 1.07e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 66 RNALTVVEKLQRQGYEAYVVGGCLRDLLLGKKPKDFDVATNARPEQIQAVFQRQ--CRLVGRRFRLAHVMFGCEIIEVAT 143
Cdd:COG0617 4 PNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRKAlrTVPVGRDFGTVTVVFGGEKIEVAT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 144 FRAGHAEHHneklakqseegmlLRD--NVYG-TLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKNGKLRLIGDPVT 220
Cdd:COG0617 84 ARTERYYGD-------------GRRpfVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDPEE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 221 RYQEDPVRMLRSIRFMAKLDMFLDKPSDAPIKSLAHLLKNIPPARLFEESLKLLQSGYGVKTYRLLRQYGLFEPLfpllt 300
Cdd:COG0617 151 RFREDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVL----- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 301 pyfteyedsmtekmilraltstdervadklpinpAFLFAAFFwYPLRERVEvlkNEGGLNNYDAYALASNDVLEQLCKSL 380
Cdd:COG0617 226 ----------------------------------ALRLAALL-HDLGKPAT---REDGLPTFHGHEEAGAELAEALLKRL 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2588609018 381 AVPRRHTAVIREIWLLQLQFL---KRTPKSVQRAIEQsKFRAGFDLLVMRAEIEGGEAVE------LAAWWHEYQF 447
Cdd:COG0617 268 RLPNRERKLVRELVELHLRFHglgELRDSAVRRLLER-GPEALEDLLLLRENGLEYPELQerlaelLEAAWRRFQP 342
|
|
| PolyA_pol |
pfam01743 |
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
82-213 |
2.58e-49 |
|
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.
Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 165.15 E-value: 2.58e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 82 AYVVGGCLRDLLLGKKPKDFDVATNARPEQIQAVFQR---QCRLVGRRFRLAHVMFGCEIIEVATFRAGHAE--HHNEKL 156
Cdd:pfam01743 1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRrriVHLLSGIEFGTIHVIFGNQILEVATFRIEFDEsdFRNPRS 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2588609018 157 AKQSeegmllrdnvyGTLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKNGKLR 213
Cdd:pfam01743 81 EEYT-----------GTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
|
|
| PRK13299 |
PRK13299 |
tRNA CCA-pyrophosphorylase; Provisional |
61-327 |
8.46e-49 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237339 [Multi-domain] Cd Length: 394 Bit Score: 172.33 E-value: 8.46e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 61 PRMFNRnALTVVEKLQRQGYEAYVVGGCLRDLLLGKKPKDFDVATNARPEQIQAVFQRQCRlVGRRFRLAHVMFGCEIIE 140
Cdd:PRK13299 3 PSEFQK-ALPILEKIKEAGFEAYFVGGSVRDYLLGRPIHDVDIATSAYPEEVKAIFPRTVD-VGIEHGTVLVLENGEEYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 141 VATFRA-GHAEHHneklaKQSEEGMLLRDnvygtLEQDAERRDFSVNALYYNpQDNTLKDYFNGIDDLKNGKLRLIGDPV 219
Cdd:PRK13299 81 VTTFRTeSEYVDY-----RRPSEVTFVRS-----LEEDLKRRDFTINAIAMD-ENGEIIDLFDGLEDLKNRLIRAVGNAE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 220 TRYQEDPVRMLRSIRFMAKLDMFLDKPSDAPIKSLAHLLKNIPPARLFEESLKLLQSGYGVKTYRLLRQYGLFEPLfpll 299
Cdd:PRK13299 150 ERFQEDALRMMRAVRFASQLGFDLETETFEAMKTQAPLLEKISVERIFVEFEKLLLGPFWRKGLKLLIETGLYNYL---- 225
|
250 260
....*....|....*....|....*...
gi 2588609018 300 tPYFTEYEDSMTEKMILRALTSTDERVA 327
Cdd:PRK13299 226 -PGLKGKEENLLKLTQLLWFSFETSEQA 252
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
67-209 |
4.32e-41 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 143.50 E-value: 4.32e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 67 NALTVVEKLQR-QGYEAYVVGGCLRDLLLGKKPKDFDVATNAR-PEQIQAVFQRQ-CRLVGR--RFRLAHVMFGCEIIEV 141
Cdd:cd05398 3 ELLKLLRELKKaLGYEAYLVGGAVRDLLLGRPPKDIDIATDADgPEFAEALFKKIgGRVVGLgeEFGTATVVINGLTIDV 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2588609018 142 ATFRAGhaehhneklaKQSEEGMLLRDNVYgTLEQDAERRDFSVNALYYNPQDNTLKDYFNGIDDLKN 209
Cdd:cd05398 83 ATLRTE----------TYTDPGRRPPVVGF-TIEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLEN 139
|
|
| PolyA_pol_arg_C |
pfam12626 |
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ... |
357-464 |
7.72e-41 |
|
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.
Pssm-ID: 463647 [Multi-domain] Cd Length: 116 Bit Score: 142.34 E-value: 7.72e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 357 GGLNNYDAYALASNDVLEQLCKSLAVPRRHTAVIREIWLLQLQFLKRTPKSVQRAIEQSKFRAGFDLLVMRAeiEGGEA- 435
Cdd:pfam12626 1 QGLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRA--ESGEVl 78
|
90 100
....*....|....*....|....*....
gi 2588609018 436 VELAAWWHEYQFSNESQRQDLVKELPSQP 464
Cdd:pfam12626 79 QELAEWWTRFQEADEAEREAMIAELGADA 107
|
|
| PolyA_pol_RNAbd |
pfam12627 |
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA ... |
240-303 |
3.46e-19 |
|
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA and SrmB binding motifs on polymerase A.
Pssm-ID: 463648 [Multi-domain] Cd Length: 64 Bit Score: 81.38 E-value: 3.46e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2588609018 240 DMFLDKPSDAPIKSLAHLLKNIPPARLFEESLKLLQSGYGVKTYRLLRQYGLFEPLFPLLTPYF 303
Cdd:pfam12627 1 GFTIEPETREAIRKLAPLLKKISPERIFEELLKLLLSGHPERGLELLRETGLLEYLFPELAAAL 64
|
|
| PRK13297 |
PRK13297 |
tRNA CCA-pyrophosphorylase; Provisional |
79-246 |
2.51e-14 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 139469 [Multi-domain] Cd Length: 364 Bit Score: 74.26 E-value: 2.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 79 GYEAYVVGGCLRDLLLGKKPKDFD-VATNARPEQIQavfQRQCRLVGRRFRLahvmfgceIIEVATfRAGHAEHHNEKLA 157
Cdd:PRK13297 11 GLQVYIVGGAVRDALLGLPAGDRDwVVVGATPEDMA---RRGFIPVGGDFPV--------FLHPRT-KEEYALARTERKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 158 KQSEEGMLLRDNVYGTLEQDAERRDFSVNALYYNPQdNTLKDYFNGIDDLKNGKLRLIGDPvtrYQEDPVRMLRSIRFMA 237
Cdd:PRK13297 79 GRGYKGFTFYTGADVTLEQDLQRRDLTVNAIARTPQ-GELVDPLDGVADVRARVLRHVGEA---FAEDPVRILRLGRFAA 154
|
....*....
gi 2588609018 238 KLDMFLDKP 246
Cdd:PRK13297 155 RFGDFSIAP 163
|
|
| cca |
PRK10885 |
multifunctional CCA addition/repair protein; |
83-239 |
1.55e-13 |
|
multifunctional CCA addition/repair protein;
Pssm-ID: 182810 [Multi-domain] Cd Length: 409 Bit Score: 72.19 E-value: 1.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 83 YVVGGCLRDLLLGKKPKDFD-VATNARPEQIQAVFQRQcrlVGRRFrlahvmfgceiievATFRagHAEHHNE-KLAKQ- 159
Cdd:PRK10885 4 YLVGGAVRDALLGLPVKDRDwVVVGATPEEMLAQGYQQ---VGKDF--------------PVFL--HPKTHEEyALARTe 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 160 --SEEGmllrdnvYG----------TLEQDAERRDFSVNALYYNPQDNtLKDYFNGIDDLKNGKLRLIGDPvtrYQEDPV 227
Cdd:PRK10885 65 rkSGRG-------YTgftcyaapdvTLEEDLIRRDLTINAMAQDDDGE-LIDPYGGQRDLEARLLRHVSPA---FAEDPL 133
|
170
....*....|..
gi 2588609018 228 RMLRSIRFMAKL 239
Cdd:PRK10885 134 RVLRVARFAARF 145
|
|
| PRK13296 |
PRK13296 |
CCA tRNA nucleotidyltransferase; |
81-260 |
3.88e-13 |
|
CCA tRNA nucleotidyltransferase;
Pssm-ID: 106256 [Multi-domain] Cd Length: 360 Bit Score: 70.78 E-value: 3.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 81 EAYVVGGCLRDLLLGKKPKDFD--VATNARPEQIQAVFQRqcrlVGRRFRLahvmfgceIIEVATfRAGHAEHHNEKLAK 158
Cdd:PRK13296 2 KFYLVGGAVRDMLLGITPKDKDwvVVGATEDEMLANGFIK----IAANFPV--------FIHPQT-KQEYALARSEKKTA 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 159 QSEEGMLLRDNVYGTLEQDAERRDFSVNALYYNpQDNTLKDYFNGIDDLKNGKLRLIGDPvtrYQEDPVRMLRSIRFMAK 238
Cdd:PRK13296 69 SGYHGFEVNFSKYITLEDDLKRRDLTINSIAID-QNNKVIDPFNGQADLQNRILRHTSIA---FIEDPLRVVRLARFKAQ 144
|
170 180
....*....|....*....|..
gi 2588609018 239 LDMFLDKPSDAPIKSLAHLLKN 260
Cdd:PRK13296 145 LSNFNFSIAQEMLALIKELVKT 166
|
|
| PRK13298 |
PRK13298 |
tRNA CCA-pyrophosphorylase; Provisional |
81-393 |
1.83e-11 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237338 [Multi-domain] Cd Length: 417 Bit Score: 65.91 E-value: 1.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 81 EAYVVGGCLRDLLLGKKPKDFD-VATNARPEQIQAVFQRQcrlVGRRFrlahvmfgceiievATFRagHAEHHNE-KLAK 158
Cdd:PRK13298 2 KIYLVGGAVRDSLLNLPVKDKDwVVVGGTPKILLSINFQQ---VGKDF--------------PVFL--HPETHEEyALAR 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 159 ------QSEEGMLLRDNVYGTLEQDAERRDFSVNALYYNPQDNTLkDYFNGIDDLKNGKLRLIGDPvtrYQEDPVRMLRS 232
Cdd:PRK13298 63 terksgVGYTGFITDTSSDVTLEEDLIRRDLTINAIAQDENGNYI-DPFQGKKDIQLRLLRHVSES---FIEDPLRVLRV 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 233 IRFMAKLDM--FLDKPSDAPIKSL---AHLLKNIPPARLFEESLKLLQSGYGVKTYRLLRQYGLFEPLFPLL-----TPY 302
Cdd:PRK13298 139 ARFAALLVHlgFKIAKETMILMCImvkKHELLYLTPERIWNETEKALKTDNPHVYFQVLYECNALKFLFPEIdflyeKPY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2588609018 303 FTeyeDSMTEKMILRALTSTDERVADKLPINPAFLFAAFFWYpLRERVEVLKNEGGLNNYDAYALASNdVLEQLCKSLAV 382
Cdd:PRK13298 219 FL---NSFFKKFNLGNYILMGLSKISKLTKDIDIRFSYLCQF-LGSMIPINQIKRNYKKIFFDKYAAS-LIKNLCKRFKI 293
|
330
....*....|.
gi 2588609018 383 PrrhtAVIREI 393
Cdd:PRK13298 294 P----SYIRNI 300
|
|
| PHA01806 |
PHA01806 |
hypothetical protein |
68-122 |
1.36e-03 |
|
hypothetical protein
Pssm-ID: 222838 Cd Length: 200 Bit Score: 39.87 E-value: 1.36e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 2588609018 68 ALTVVEKLQRQGYEAYVVGGCLRDLLLGKKPKDFDVATnARPEQIQAVFQRQCRL 122
Cdd:PHA01806 24 LLLRLYSDARHSEGVALAGGAARDLMHGAEPKDIDIAL-YGMDDRQAELLIGCIL 77
|
|
| |
