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Conserved domains on  [gi|2631531332|ref|WP_321170002|]
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GNAT family N-acetyltransferase [Priestia endophytica]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 50-113 4.53e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 60.05  E-value: 4.53e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2631531332  50 EAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKDGEP---LYGCRGFNFKGSEESY 113
Cdd:COG0456    13 EAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAaiaLYEKLGFEEVGERPNY 79
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 50-113 4.53e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 60.05  E-value: 4.53e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2631531332  50 EAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKDGEP---LYGCRGFNFKGSEESY 113
Cdd:COG0456    13 EAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAaiaLYEKLGFEEVGERPNY 79
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 42-90 1.14e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.05  E-value: 1.14e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2631531332  42 YLEDLQGIEAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLH 90
Cdd:cd04301    17 SPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 42-104 3.91e-09

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.59  E-value: 3.91e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2631531332  42 YLEDLQGIEAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKDGEP---LYGCRGF 104
Cdd:pfam00583  51 SIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAaiaLYEKLGF 116
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 50-105 3.51e-07

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 45.69  E-value: 3.51e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2631531332  50 EAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWL-------HASKdgepLYGCRGFN 105
Cdd:PRK09491   63 EATLFNIAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLevrasnaAAIA----LYESLGFN 121
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 50-113 4.53e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 60.05  E-value: 4.53e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2631531332  50 EAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKDGEP---LYGCRGFNFKGSEESY 113
Cdd:COG0456    13 EAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAaiaLYEKLGFEEVGERPNY 79
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
50-104 1.18e-12

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 59.81  E-value: 1.18e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2631531332  50 EAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKDGEPLYGCRGF 104
Cdd:COG2153    58 EAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHAVGFYEKLGF 112
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
51-104 1.23e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.40  E-value: 1.23e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2631531332  51 AYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKDGEPLYGCRGF 104
Cdd:COG3153    68 LLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGF 121
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 51-104 5.22e-11

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 55.77  E-value: 5.22e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2631531332  51 AYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKDGEPLYGCRGF 104
Cdd:COG1246    53 AELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGF 106
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 42-90 1.14e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.05  E-value: 1.14e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2631531332  42 YLEDLQGIEAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLH 90
Cdd:cd04301    17 SPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 9-99 7.83e-10

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 52.75  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2631531332   9 ETEISNNHFVSYIAKNDEGVV----SVRGVFFkkrpsYLEDLQGI-------------EAYIFNMYTLPAHRSQGLARQL 71
Cdd:COG0454     5 KATPEDINFILLIEALDAELKamegSLAGAEF-----IAVDDKGEpigfaglrrlddkVLELKRLYVLPEYRGKGIGKAL 79

                          90       100
                  ....*....|....*....|....*...
gi 2631531332  72 FEKCIEECKKRNVKGIWLHASKDGEPLY 99
Cdd:COG0454    80 LEALLEWARERGCTALELDTLDGNPAAI 107
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 42-104 3.91e-09

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.59  E-value: 3.91e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2631531332  42 YLEDLQGIEAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKDGEP---LYGCRGF 104
Cdd:pfam00583  51 SIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAaiaLYEKLGF 116
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
51-94 1.87e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 47.98  E-value: 1.87e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2631531332  51 AYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKD 94
Cdd:COG3393    16 AEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDAD 59
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 8-110 5.24e-08

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 47.65  E-value: 5.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2631531332   8 LETEISNNHFVSYIAKNDE---GVVSVRGvffkkrpsyledlqgiEAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNV 84
Cdd:pfam13673  22 LRERIDQGEYFFFVAFEGGqivGVIALRD----------------RGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGI 85

                          90       100
                  ....*....|....*....|....*...
gi 2631531332  85 KG--IWLHASKDGEPLYGCRGFNFKGSE 110
Cdd:pfam13673  86 KLseLTVNASPYAVPFYEKLGFRATGPE 113
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 20-104 1.09e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 45.91  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2631531332  20 YIAKNDEGVVSVRGVFFKKRPSYLEDLqgieayifNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKDGEPLY 99
Cdd:pfam13508   6 FVAEDDGKIVGFAALLPLDDEGALAEL--------RLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFY 77


                  ....*
gi 2631531332 100 GCRGF 104
Cdd:pfam13508  78 EKLGF 82
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 50-105 3.51e-07

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 45.69  E-value: 3.51e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2631531332  50 EAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIWL-------HASKdgepLYGCRGFN 105
Cdd:PRK09491   63 EATLFNIAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLevrasnaAAIA----LYESLGFN 121
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
10-97 3.01e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 43.44  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2631531332  10 TEISNNHFVSYIAKNDEGVV-SVRGVFFKKRPSYLEdlqgieAYIFNMYTLPAHRSQGLARQLFEKCIEECKKRNVKGIW 88
Cdd:COG1247    45 AAILAPGRPVLVAEEDGEVVgFASLGPFRPRPAYRG------TAEESIYVDPDARGRGIGRALLEALIERARARGYRRLV 118


                  ....*....
gi 2631531332  89 LHASKDGEP 97
Cdd:COG1247   119 AVVLADNEA 127
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 58-104 6.37e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 36.78  E-value: 6.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2631531332  58 TLPAHRSQGLARQLFEKCIEECKKRNVKGIWLHASKdgEPLYGCRGF 104
Cdd:pfam13527  78 TYPEYRGRGVMSRLLRRSLEEMRERGVPLSFLYPSS--YPIYRRFGY 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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