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Conserved domains on  [gi|2644345368|ref|WP_323424548|]
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Fur family transcriptional regulator [Proteiniphilum sp.]

Protein Classification

Fur family transcriptional regulator( domain architecture ID 10002362)

Fur (ferric uptake regulator) family transcriptional regulator such as metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria

CATH:  3.30.1490.190|1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677|GO:0046872
PubMed:  17216355|24106689

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
1-132 1.44e-27

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


:

Pssm-ID: 440498  Cd Length: 140  Bit Score: 98.87  E-value: 1.44e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368   1 MTVEEILHAHDLKNTGCRKYILGELLKNEAAMS----ENELKESYPDLfDRVTLYRTLKTLEDRGIIHRIVLNDNTVKYA 76
Cdd:COG0735     5 EEAEELLREAGLRLTPQRLAILELLLESDRHLSaeeiYEALRKKGPSI-SLATVYRTLDLLVEAGLVHRIEFGGGKARYE 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368  77 LNRHHHendklHSHFHCEKCDEVLCLDGVT----HFDAELPKGFISKEVFVVVEGLCADC 132
Cdd:COG0735    84 LNEGDH-----HHHLICTKCGKVIELDDDEieelLEELAEPHGFEIESHELEIYGLCPDC 138
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
1-132 1.44e-27

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 98.87  E-value: 1.44e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368   1 MTVEEILHAHDLKNTGCRKYILGELLKNEAAMS----ENELKESYPDLfDRVTLYRTLKTLEDRGIIHRIVLNDNTVKYA 76
Cdd:COG0735     5 EEAEELLREAGLRLTPQRLAILELLLESDRHLSaeeiYEALRKKGPSI-SLATVYRTLDLLVEAGLVHRIEFGGGKARYE 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368  77 LNRHHHendklHSHFHCEKCDEVLCLDGVT----HFDAELPKGFISKEVFVVVEGLCADC 132
Cdd:COG0735    84 LNEGDH-----HHHLICTKCGKVIELDDDEieelLEELAEPHGFEIESHELEIYGLCPDC 138
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 18-129 9.86e-15

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 65.29  E-value: 9.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368  18 RKYILGELLKNEAAMSENE----LKESYPDLfDRVTLYRTLKTLEDRGIIHRIVLNDNTVKYALNRHHHendklHSHFHC 93
Cdd:cd07153     3 RLAILEVLLESDGHLTAEEiyerLRKKGPSI-SLATVYRTLELLEEAGLVREIELGDGKARYELNTDEH-----HHHLIC 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2644345368  94 EKCDEV--LCLDGVTHFDAELPK--GFISKEVFVVVEGLC 129
Cdd:cd07153    77 TKCGKVidFEDCPLEELLEELAAktGFKITSHRLELYGIC 116
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 12-99 1.86e-08

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 49.16  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368  12 LKNTGCRKYILGELLKNEAAMSE-----NELKESYPDLfDRVTLYRTLKTLEDRGIIHRIVLNDNTVKYALNRHHHendk 86
Cdd:pfam01475   4 LKLTPQRLKILEVLQKSDKEHLSaeeiyKELREEDPNI-SLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHH---- 78

                          90
                  ....*....|...
gi 2644345368  87 lHSHFHCEKCDEV 99
Cdd:pfam01475  79 -HDHLICEDCGKV 90
PRK11639 PRK11639
zinc uptake transcriptional repressor Zur;
49-132 4.91e-04

zinc uptake transcriptional repressor Zur;


Pssm-ID: 183251  Cd Length: 169  Bit Score: 37.82  E-value: 4.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368  49 TLYRTLKTLEDRGIIHRIvlnDNTVKYALNrHHHENdklHSH----FHCEKCDEVL--CLDGVTHFDAELPK--GFISKE 120
Cdd:PRK11639   62 TVYRALDFLLEQGFVHKV---ESTNSYVLC-HLFDQ---PTHtsamFICDRCGAVKeeCAEGVEDIMHTLAAkmGFALRH 134

                          90
                  ....*....|..
gi 2644345368 121 VFVVVEGLCADC 132
Cdd:PRK11639  135 NVIEAHGLCAAC 146
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
1-132 1.44e-27

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 98.87  E-value: 1.44e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368   1 MTVEEILHAHDLKNTGCRKYILGELLKNEAAMS----ENELKESYPDLfDRVTLYRTLKTLEDRGIIHRIVLNDNTVKYA 76
Cdd:COG0735     5 EEAEELLREAGLRLTPQRLAILELLLESDRHLSaeeiYEALRKKGPSI-SLATVYRTLDLLVEAGLVHRIEFGGGKARYE 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368  77 LNRHHHendklHSHFHCEKCDEVLCLDGVT----HFDAELPKGFISKEVFVVVEGLCADC 132
Cdd:COG0735    84 LNEGDH-----HHHLICTKCGKVIELDDDEieelLEELAEPHGFEIESHELEIYGLCPDC 138
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 18-129 9.86e-15

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 65.29  E-value: 9.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368  18 RKYILGELLKNEAAMSENE----LKESYPDLfDRVTLYRTLKTLEDRGIIHRIVLNDNTVKYALNRHHHendklHSHFHC 93
Cdd:cd07153     3 RLAILEVLLESDGHLTAEEiyerLRKKGPSI-SLATVYRTLELLEEAGLVREIELGDGKARYELNTDEH-----HHHLIC 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2644345368  94 EKCDEV--LCLDGVTHFDAELPK--GFISKEVFVVVEGLC 129
Cdd:cd07153    77 TKCGKVidFEDCPLEELLEELAAktGFKITSHRLELYGIC 116
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 12-99 1.86e-08

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 49.16  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368  12 LKNTGCRKYILGELLKNEAAMSE-----NELKESYPDLfDRVTLYRTLKTLEDRGIIHRIVLNDNTVKYALNRHHHendk 86
Cdd:pfam01475   4 LKLTPQRLKILEVLQKSDKEHLSaeeiyKELREEDPNI-SLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHH---- 78

                          90
                  ....*....|...
gi 2644345368  87 lHSHFHCEKCDEV 99
Cdd:pfam01475  79 -HDHLICEDCGKV 90
PRK11639 PRK11639
zinc uptake transcriptional repressor Zur;
49-132 4.91e-04

zinc uptake transcriptional repressor Zur;


Pssm-ID: 183251  Cd Length: 169  Bit Score: 37.82  E-value: 4.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2644345368  49 TLYRTLKTLEDRGIIHRIvlnDNTVKYALNrHHHENdklHSH----FHCEKCDEVL--CLDGVTHFDAELPK--GFISKE 120
Cdd:PRK11639   62 TVYRALDFLLEQGFVHKV---ESTNSYVLC-HLFDQ---PTHtsamFICDRCGAVKeeCAEGVEDIMHTLAAkmGFALRH 134

                          90
                  ....*....|..
gi 2644345368 121 VFVVVEGLCADC 132
Cdd:PRK11639  135 NVIEAHGLCAAC 146
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
35-77 1.60e-03

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 35.61  E-value: 1.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2644345368  35 NELKESYPDLFDRVtLYRTLKTLEDRGIIHRIVLNDN--TVKYAL 77
Cdd:COG1733    39 GELRRSLPGISQKM-LTQRLRELEEDGLVERTVYPEVppRVEYSL 82
PRK06474 PRK06474
hypothetical protein; Provisional
 18-78 6.26e-03

hypothetical protein; Provisional


Pssm-ID: 235811  Cd Length: 178  Bit Score: 35.11  E-value: 6.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2644345368  18 RKYILGELLKNEAAMSENELKESYPDLfDRVTLYRTLKTLEDRGIIHriVLNDNTVK------YALN 78
Cdd:PRK06474   13 RMKICQVLMRNKEGLTPLELVKILKDV-PQATLYRHLQTMVDSGILH--VVKEKKVRsvsekyYAIN 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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