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Conserved domains on  [gi|2674045042|ref|WP_331645412|]
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pyridoxal-phosphate dependent enzyme [Luteibacter sp.]

Protein Classification

threonine/serine dehydratase( domain architecture ID 11439432)

serine/threonine dehydratase deaminates L-threonine or L-serine to form 2-oxobutanoate or pyruvate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 1-313 1.18e-129

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


:

Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 372.06  E-value: 1.18e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   1 MLPSFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNH 80
Cdd:COG1171     4 LMPTLADIEAAAARIAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASLSEEERARGVVAASAGNH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  81 GNALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLV 160
Cdd:COG1171    84 AQGVAYAARLLGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATFVHPFDDPDVIAGQGTIA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 161 PELLQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT-LIGEP 239
Cdd:COG1171   164 LEILEQLPDLDAVFVPVGGGGLIAGVAAALKALSPDIRVIGVEPEGAAAMYRSLAAGEPVTLPGVDTIADGLAVgRPGEL 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674045042 240 NFHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVDLDALPW 313
Cdd:COG1171   244 TFEILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKERLKGKRVVVVLSGGNIDPDRLAE 317
 
Name Accession Description Interval E-value
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 1-313 1.18e-129

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 372.06  E-value: 1.18e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   1 MLPSFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNH 80
Cdd:COG1171     4 LMPTLADIEAAAARIAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASLSEEERARGVVAASAGNH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  81 GNALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLV 160
Cdd:COG1171    84 AQGVAYAARLLGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATFVHPFDDPDVIAGQGTIA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 161 PELLQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT-LIGEP 239
Cdd:COG1171   164 LEILEQLPDLDAVFVPVGGGGLIAGVAAALKALSPDIRVIGVEPEGAAAMYRSLAAGEPVTLPGVDTIADGLAVgRPGEL 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674045042 240 NFHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVDLDALPW 313
Cdd:COG1171   244 TFEILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKERLKGKRVVVVLSGGNIDPDRLAE 317
PLN02970 PLN02970
serine racemase
 4-311 3.26e-127

serine racemase


Pssm-ID: 215524 [Multi-domain]  Cd Length: 328  Bit Score: 365.93  E-value: 3.26e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   4 SFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNA 83
Cdd:PLN02970   10 DLSSIREARKRIAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAEKGVVTHSSGNHAAA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  84 LAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPEL 163
Cdd:PLN02970   90 LALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHPYNDGRVISGQGTIALEF 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 164 LQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRTLIGEPNFHA 243
Cdd:PLN02970  170 LEQVPELDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGADDAAQSKAAGEIITLPVTNTIADGLRASLGDLTWPV 249

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2674045042 244 LRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLR-----YPAHFSGRNVGAVITGGNVDLDAL 311
Cdd:PLN02970  250 VRDLVDDVITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSdsfrsNPAWKGCKNVGIVLSGGNVDLGVL 322
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 5-307 6.17e-120

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 346.78  E-value: 6.17e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   5 FAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNAL 84
Cdd:cd01562     1 LEDILAAAARIKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSLSEEERAKGVVAASAGNHAQGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  85 AMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELL 164
Cdd:cd01562    81 AYAAKLLGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHPFDDPDVIAGQGTIGLEIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 165 QQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT-LIGEPNFHA 243
Cdd:cd01562   161 EQVPDLDAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGAPAMAQSLAAGKPVTLPEVDTIADGLAVkRPGELTFEI 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674045042 244 LRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVD 307
Cdd:cd01562   241 IRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLDLKGKKVVVVLSGGNID 304
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 15-303 3.33e-74

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 229.89  E-value: 3.33e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  15 IAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNALAMAARTRGIA 94
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGEGGKTVVEASSGNHGRALAAAAARLGLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  95 AHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAA-TGANLVHPYADARVMAGQGTLVPELLQQAPG-IDT 172
Cdd:pfam00291  81 VTIVVPEDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEgPGAYYINQYDNPLNIEGYGTIGLEILEQLGGdPDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 173 ILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT--LIGEPNFHALRDHQVR 250
Cdd:pfam00291 161 VVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSLAAGRPVPVPVADTIADGLGVgdEPGALALDLLDEYVGE 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2674045042 251 VLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAM-LRYPAHFS-GRNVGAVITG 303
Cdd:pfam00291 241 VVTVSDEEALEAMRLLARREGIVVEPSSAAALAALkLALAGELKgGDRVVVVLTG 295
ilvA_1Cterm TIGR01127
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ...
 22-311 1.68e-63

threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130197 [Multi-domain]  Cd Length: 380  Bit Score: 205.36  E-value: 1.68e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNALAMAARTRGIAAHVVVPE 101
Cdd:TIGR01127   1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGALNKIANLSEDQRQRGVVAASAGNHAQGVAYAAKKFGIKAVIVMPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 102 GAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELLQQAPGIDTILFPVGGGG 181
Cdd:TIGR01127  81 SAPPSKVKATKSYGAEVILHGDDYDEAYAFATSLAEEEGRVFVHPFDDEFVMAGQGTIGLEIMEDIPDVDTVIVPVGGGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 182 LAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT-LIGEPNFHALRDHQVRVLRVSDDDVV 260
Cdd:TIGR01127 161 LISGVASAAKQINPNVKVIGVEAEGAPSMYESLREGKIKAVESVRTIADGIAVkKPGDLTFNIIKEYVDDVVTVDEEEIA 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2674045042 261 AAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVDLDAL 311
Cdd:TIGR01127 241 NAIYLLLERHKILAEGAGAAGVAALLEQKVDVKGKKIAVVLSGGNIDLNLL 291
 
Name Accession Description Interval E-value
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 1-313 1.18e-129

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 372.06  E-value: 1.18e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   1 MLPSFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNH 80
Cdd:COG1171     4 LMPTLADIEAAAARIAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASLSEEERARGVVAASAGNH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  81 GNALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLV 160
Cdd:COG1171    84 AQGVAYAARLLGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATFVHPFDDPDVIAGQGTIA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 161 PELLQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT-LIGEP 239
Cdd:COG1171   164 LEILEQLPDLDAVFVPVGGGGLIAGVAAALKALSPDIRVIGVEPEGAAAMYRSLAAGEPVTLPGVDTIADGLAVgRPGEL 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674045042 240 NFHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVDLDALPW 313
Cdd:COG1171   244 TFEILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKERLKGKRVVVVLSGGNIDPDRLAE 317
PLN02970 PLN02970
serine racemase
 4-311 3.26e-127

serine racemase


Pssm-ID: 215524 [Multi-domain]  Cd Length: 328  Bit Score: 365.93  E-value: 3.26e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   4 SFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNA 83
Cdd:PLN02970   10 DLSSIREARKRIAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAEKGVVTHSSGNHAAA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  84 LAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPEL 163
Cdd:PLN02970   90 LALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHPYNDGRVISGQGTIALEF 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 164 LQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRTLIGEPNFHA 243
Cdd:PLN02970  170 LEQVPELDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGADDAAQSKAAGEIITLPVTNTIADGLRASLGDLTWPV 249

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2674045042 244 LRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLR-----YPAHFSGRNVGAVITGGNVDLDAL 311
Cdd:PLN02970  250 VRDLVDDVITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSdsfrsNPAWKGCKNVGIVLSGGNVDLGVL 322
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 5-307 6.17e-120

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 346.78  E-value: 6.17e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   5 FAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNAL 84
Cdd:cd01562     1 LEDILAAAARIKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSLSEEERAKGVVAASAGNHAQGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  85 AMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELL 164
Cdd:cd01562    81 AYAAKLLGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHPFDDPDVIAGQGTIGLEIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 165 QQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT-LIGEPNFHA 243
Cdd:cd01562   161 EQVPDLDAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGAPAMAQSLAAGKPVTLPEVDTIADGLAVkRPGELTFEI 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674045042 244 LRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVD 307
Cdd:cd01562   241 IRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLDLKGKKVVVVLSGGNID 304
PRK07048 PRK07048
threo-3-hydroxy-L-aspartate ammonia-lyase;
2-311 3.96e-91

threo-3-hydroxy-L-aspartate ammonia-lyase;


Pssm-ID: 235918 [Multi-domain]  Cd Length: 321  Bit Score: 274.20  E-value: 3.96e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   2 LPSFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHG 81
Cdd:PRK07048    5 LPTYDDVAAAAARLAGVAHRTPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGAYNALSQFSPEQRRAGVVTFSSGNHA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  82 NALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVP 161
Cdd:PRK07048   85 QAIALSARLLGIPATIVMPQDAPAAKVAATRGYGGEVVTYDRYTEDREEIGRRLAEERGLTLIPPYDHPHVIAGQGTAAK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 162 ELLQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRTL-IGEPN 240
Cdd:PRK07048  165 ELFEEVGPLDALFVCLGGGGLLSGCALAARALSPGCKVYGVEPEAGNDGQQSFRSGEIVHIDTPRTIADGAQTQhLGNYT 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2674045042 241 FHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVDLDAL 311
Cdd:PRK07048  245 FPIIRRLVDDIVTVSDAELVDAMRFFAERMKIVVEPTGCLGAAAALRGKVPLKGKRVGVIISGGNVDLARF 315
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 15-303 3.33e-74

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 229.89  E-value: 3.33e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  15 IAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNALAMAARTRGIA 94
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGEGGKTVVEASSGNHGRALAAAAARLGLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  95 AHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAA-TGANLVHPYADARVMAGQGTLVPELLQQAPG-IDT 172
Cdd:pfam00291  81 VTIVVPEDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEgPGAYYINQYDNPLNIEGYGTIGLEILEQLGGdPDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 173 ILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT--LIGEPNFHALRDHQVR 250
Cdd:pfam00291 161 VVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSLAAGRPVPVPVADTIADGLGVgdEPGALALDLLDEYVGE 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2674045042 251 VLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAM-LRYPAHFS-GRNVGAVITG 303
Cdd:pfam00291 241 VVTVSDEEALEAMRLLARREGIVVEPSSAAALAALkLALAGELKgGDRVVVVLTG 295
PRK06815 PRK06815
threonine/serine dehydratase;
5-311 5.94e-71

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 222.26  E-value: 5.94e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   5 FAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNAL 84
Cdd:PRK06815    4 FDAILEAHQRLRPQVRVTPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKLRLLNEAQRQQGVITASSGNHGQGV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  85 AMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELL 164
Cdd:PRK06815   84 ALAAKLAGIPVTVYAPEQASAIKLDAIRALGAEVRLYGGDALNAELAARRAAEQQGKVYISPYNDPQVIAGQGTIGMELV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 165 QQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGlrTLIG-EPN--- 240
Cdd:PRK06815  164 EQQPDLDAVFVAVGGGGLISGIATYLKTLSPKTEIIGCWPANSPSLYTSLEAGEIVEVAEQPTLSDG--TAGGvEPGait 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2674045042 241 FHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVDLDAL 311
Cdd:PRK06815  242 FPLCQQLIDQKVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAALKLAPRYQGKKVAVVLCGKNIVLEKY 312
PRK08638 PRK08638
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
4-308 7.85e-68

bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;


Pssm-ID: 236317 [Multi-domain]  Cd Length: 333  Bit Score: 214.98  E-value: 7.85e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   4 SFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNA 83
Cdd:PRK08638   10 AIDDIIEAKQRLAGRIRKTPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAFNKLSSLTDAEKRKGVVACSAGNHAQG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  84 LAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPEL 163
Cdd:PRK08638   90 VALSCALLGIDGKVVMPKGAPKSKVAATCGYGAEVVLHGDNFNDTIAKVEEIVEEEGRTFIPPYDDPKVIAGQGTIGLEI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 164 LQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRTLI-GEPNFH 242
Cdd:PRK08638  170 LEDLWDVDTVIVPIGGGGLIAGIAVALKSINPTIHIIGVQSENVHGMAASFYAGEITTHRTTGTLADGCDVSRpGNLTYE 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2674045042 243 ALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAML--RYPAHFSGRNVGAVITGGNVDL 308
Cdd:PRK08638  250 IVRELVDDIVLVSEDEIRNAMKDLIQRNKVVTEGAGALATAALLsgKLDQYIQNKKVVAIISGGNVDL 317
PRK08639 PRK08639
threonine dehydratase; Validated
 1-312 1.42e-63

threonine dehydratase; Validated


Pssm-ID: 236318 [Multi-domain]  Cd Length: 420  Bit Score: 206.58  E-value: 1.42e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   1 MLPSFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNH 80
Cdd:PRK08639    5 MTVSAKDIDKAAKRLKDVVPETPLQRNDYLSEKYGANVYLKREDLQPVRSYKLRGAYNAISQLSDEELAAGVVCASAGNH 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  81 GNALAMAARTRGIAAHVVVPEGAVKAKVDA----------IIAAGATIHRCAATtqareakAAEIMAATGANLVHPYADA 150
Cdd:PRK08639   85 AQGVAYACRHLGIPGVIFMPVTTPQQKIDQvrffggefveIVLVGDTFDDSAAA-------AQEYAEETGATFIPPFDDP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 151 RVMAGQGTLVPELLQQA---PGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVgpfTPST 227
Cdd:PRK08639  158 DVIAGQGTVAVEILEQLekeGSPDYVFVPVGGGGLISGVTTYLKERSPKTKIIGVEPAGAASMKAALEAGKPV---TLEK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 228 I---CDG--LRTlIGEPNFHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVIT 302
Cdd:PRK08639  235 IdkfVDGaaVAR-VGDLTFEILKDVVDDVVLVPEGAVCTTILELYNKEGIVAEPAGALSIAALELYKDEIKGKTVVCVIS 313

                         330
                  ....*....|
gi 2674045042 303 GGNVDLDALP 312
Cdd:PRK08639  314 GGNNDIERMP 323
ilvA_1Cterm TIGR01127
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ...
 22-311 1.68e-63

threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130197 [Multi-domain]  Cd Length: 380  Bit Score: 205.36  E-value: 1.68e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNALAMAARTRGIAAHVVVPE 101
Cdd:TIGR01127   1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGALNKIANLSEDQRQRGVVAASAGNHAQGVAYAAKKFGIKAVIVMPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 102 GAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELLQQAPGIDTILFPVGGGG 181
Cdd:TIGR01127  81 SAPPSKVKATKSYGAEVILHGDDYDEAYAFATSLAEEEGRVFVHPFDDEFVMAGQGTIGLEIMEDIPDVDTVIVPVGGGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 182 LAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT-LIGEPNFHALRDHQVRVLRVSDDDVV 260
Cdd:TIGR01127 161 LISGVASAAKQINPNVKVIGVEAEGAPSMYESLREGKIKAVESVRTIADGIAVkKPGDLTFNIIKEYVDDVVTVDEEEIA 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2674045042 261 AAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVDLDAL 311
Cdd:TIGR01127 241 NAIYLLLERHKILAEGAGAAGVAALLEQKVDVKGKKIAVVLSGGNIDLNLL 291
PRK08246 PRK08246
serine/threonine dehydratase;
1-311 2.34e-63

serine/threonine dehydratase;


Pssm-ID: 181319 [Multi-domain]  Cd Length: 310  Bit Score: 202.49  E-value: 2.34e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   1 MLPSFAEIRDAAARIAPHARVTPAMRSELIDARvGAAVWFKCENLQRGGAFKFRGATNAVwsLTDEEAARGVVTHSSGNH 80
Cdd:PRK08246    3 AMITRSDVRAAAQRIAPHIRRTPVLEADGAGFG-PAPVWLKLEHLQHTGSFKARGAFNRL--LAAPVPAAGVVAASGGNA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  81 GNALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLV 160
Cdd:PRK08246   80 GLAVAYAAAALGVPATVFVPETAPPAKVARLRALGAEVVVVGAEYADALEAAQAFAAETGALLCHAYDQPEVLAGAGTLG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 161 PELLQQAPGIDTILFPVGGGGLAAGCSIAAHGidpAIALFGAEPEGADDAARSLEA----DARVGPFTPSTIcdGLRTlI 236
Cdd:PRK08246  160 LEIEEQAPGVDTVLVAVGGGGLIAGIAAWFEG---RARVVAVEPEGAPTLHAALAAgepvDVPVSGIAADSL--GARR-V 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2674045042 237 GEPNFHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAML--RY-PAhfSGRNVGAVITGGNVDLDAL 311
Cdd:PRK08246  234 GEIAFALARAHVVTSVLVSDEAIIAARRALWEELRLAVEPGAATALAALLsgAYvPA--PGERVAVVLCGANTDPATL 309
eutB PRK07476
threonine dehydratase; Provisional
 4-310 2.67e-62

threonine dehydratase; Provisional


Pssm-ID: 236025 [Multi-domain]  Cd Length: 322  Bit Score: 200.19  E-value: 2.67e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   4 SFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNA 83
Cdd:PRK07476    2 SLADIYRARRRIAGRVRRTPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNALLSLSAQERARGVVTASTGNHGRA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  84 LAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPEL 163
Cdd:PRK07476   82 LAYAARALGIRATICMSRLVPANKVDAIRALGAEVRIVGRSQDDAQAEVERLVREEGLTMVPPFDDPRIIAGQGTIGLEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 164 LQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPE-GADDAArSLEADARVGPFTPSTICDGLRTLIGEPN-- 240
Cdd:PRK07476  162 LEALPDVATVLVPLSGGGLASGVAAAVKAIRPAIRVIGVSMErGAAMHA-SLAAGRPVQVEEVPTLADSLGGGIGLDNry 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2674045042 241 -FHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVDLDA 310
Cdd:PRK07476  241 tFAMCRALLDDVVLLDEAEIAAGIRHAYREERLVVEGAGAVGIAALLAGKIAARDGPIVVVVSGANIDMEL 311
PRK07334 PRK07334
threonine dehydratase; Provisional
 4-307 8.11e-62

threonine dehydratase; Provisional


Pssm-ID: 235994 [Multi-domain]  Cd Length: 403  Bit Score: 201.66  E-value: 8.11e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   4 SFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNA 83
Cdd:PRK07334    6 TLADIRAAAARLAGQVLRTPCVHSRTLSQITGAEVWLKFENLQFTASFKERGALNKLLLLTEEERARGVIAMSAGNHAQG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  84 LAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPEL 163
Cdd:PRK07334   86 VAYHAQRLGIPATIVMPRFTPTVKVERTRGFGAEVVLHGETLDEARAHARELAEEEGLTFVHPYDDPAVIAGQGTVALEM 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 164 LQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARvgPFTPSTICDGLR-TLIGEPNFH 242
Cdd:PRK07334  166 LEDAPDLDTLVVPIGGGGLISGMATAAKALKPDIEIIGVQTELYPSMYAAIKGVAL--PCGGSTIAEGIAvKQPGQLTLE 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2674045042 243 ALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVD 307
Cdd:PRK07334  244 IVRRLVDDILLVSEADIEQAVSLLLEIEKTVVEGAGAAGLAALLAYPERFRGRKVGLVLSGGNID 308
PRK06608 PRK06608
serine/threonine dehydratase;
2-307 8.99e-61

serine/threonine dehydratase;


Pssm-ID: 235842 [Multi-domain]  Cd Length: 338  Bit Score: 196.92  E-value: 8.99e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   2 LPSFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEA-ARGVVTHSSGNH 80
Cdd:PRK06608    4 LQNPQNIAAAHNRIKQYLHLTPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGVLNHLLELKEQGKlPDKIVAYSTGNH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  81 GNALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCaATTQAREAKAAEIMaATGANLVHPYADARVMAGQGTLV 160
Cdd:PRK06608   84 GQAVAYASKLFGIKTRIYLPLNTSKVKQQAALYYGGEVILT-NTRQEAEEKAKEDE-EQGFYYIHPSDSDSTIAGAGTLC 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 161 PELLQQ-APGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVG-PFTPSTICDGLRTL-IG 237
Cdd:PRK06608  162 YEALQQlGFSPDAIFASCGGGGLISGTYLAKELISPTSLLIGSEPLNANDAYLSLKNNKIYRlNYSPNTIADGLKTLsVS 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2674045042 238 EPNFHALR--DHQVRVlrvsDDDVVAamrlMWTE-----LRVIVEPSSATTLAAMLRYPAHFSG-RNVGAVITGGNVD 307
Cdd:PRK06608  242 ARTFEYLKklDDFYLV----EEYEIY----YWTAwlthlLKVICEPSSAINMVAVVNWLKTQSKpQKLLVILSGGNID 311
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 22-304 1.94e-56

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 182.71  E-value: 1.94e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARG--VVTHSSGNHGNALAMAARTRGIAAHVVV 99
Cdd:cd00640     1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKLPKgvIIESTGGNTGIALAAAAARLGLKCTIVM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 100 PEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAAT-GANLVHPYADARVMAGQGTLVPELLQQAPG--IDTILFP 176
Cdd:cd00640    81 PEGASPEKVAQMRALGAEVVLVPGDFDDAIALAKELAEEDpGAYYVNQFDNPANIAGQGTIGLEILEQLGGqkPDAVVVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 177 VGGGGLAAGCSIAAHGIDPAIALFGAEPEgaddaarsleadarvgpftpsticdglrtligepnfhalrdhqvrVLRVSD 256
Cdd:cd00640   161 VGGGGNIAGIARALKELLPNVKVIGVEPE---------------------------------------------VVTVSD 195

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2674045042 257 DDVVAAMRLMWTELRVIVEPSSATTLAAMLRY-PAHFSGRNVGAVITGG 304
Cdd:cd00640   196 EEALEAIRLLAREEGILVEPSSAAALAAALKLaKKLGKGKTVVVILTGG 244
PRK09224 PRK09224
threonine ammonia-lyase IlvA;
19-311 8.07e-56

threonine ammonia-lyase IlvA;


Pssm-ID: 236417 [Multi-domain]  Cd Length: 504  Bit Score: 188.42  E-value: 8.07e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  19 ARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNALAMAARTRGIAAHVV 98
Cdd:PRK09224   18 AQETPLEKAPKLSARLGNQVLLKREDLQPVFSFKLRGAYNKMAQLTEEQLARGVITASAGNHAQGVALSAARLGIKAVIV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  99 VPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELLQQAPG-IDTILFPV 177
Cdd:PRK09224   98 MPVTTPDIKVDAVRAFGGEVVLHGDSFDEAYAHAIELAEEEGLTFIHPFDDPDVIAGQGTIAMEILQQHPHpLDAVFVPV 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 178 GGGGLAAGcsIAAH--GIDPAIALFGAEPEGADDAARSLEAD-----ARVGPFTpsticDGLRT-LIGEPNFHALRDHQV 249
Cdd:PRK09224  178 GGGGLIAG--VAAYikQLRPEIKVIGVEPEDSACLKAALEAGervdlPQVGLFA-----DGVAVkRIGEETFRLCQEYVD 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674045042 250 RVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPA--HFSGRNVGAVITGGNVDLDAL 311
Cdd:PRK09224  251 DVITVDTDEICAAIKDVFEDTRSIAEPAGALALAGLKKYVAqhGIEGETLVAILSGANMNFDRL 314
PRK12483 PRK12483
threonine dehydratase; Reviewed
 12-311 1.14e-53

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 183.07  E-value: 1.14e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  12 AARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNALAMAARTR 91
Cdd:PRK12483   28 AARVYDVARETPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGAYNKMARLPAEQLARGVITASAGNHAQGVALAAARL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  92 GIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELLQQAPG-I 170
Cdd:PRK12483  108 GVKAVIVMPRTTPQLKVDGVRAHGGEVVLHGESFPDALAHALKLAEEEGLTFVPPFDDPDVIAGQGTVAMEILRQHPGpL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 171 DTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT-LIGEPNFHALRDHQV 249
Cdd:PRK12483  188 DAIFVPVGGGGLIAGIAAYVKYVRPEIKVIGVEPDDSNCLQAALAAGERVVLGQVGLFADGVAVaQIGEHTFELCRHYVD 267

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674045042 250 RVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAH--FSGRNVGAVITGGNVDLDAL 311
Cdd:PRK12483  268 EVVTVSTDELCAAIKDIYDDTRSITEPAGALAVAGIKKYAERegIEGQTLVAIDSGANVNFDRL 331
ectoine_eutB TIGR02991
ectoine utilization protein EutB; Members of this protein family are EutB, a predicted ...
 4-310 1.78e-47

ectoine utilization protein EutB; Members of this protein family are EutB, a predicted arylmalonate decarboxylase found in a conserved ectoine utilization operon of species that include Sinorhizobium meliloti 1021 (where it is known to be induced by ectoine), Mesorhizobium loti, Silicibacter pomeroyi, Agrobacterium tumefaciens, and Pseudomonas putida. Members of this family resemble threonine dehydratases.


Pssm-ID: 132036 [Multi-domain]  Cd Length: 317  Bit Score: 161.94  E-value: 1.78e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   4 SFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNA 83
Cdd:TIGR02991   2 TLQDIERAAARISGRVEETPLVESPSLSELCGVPVHLKLEHRQTTGSFKLRGATNAVLSLSDTQRAAGVVAASTGNHGRA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  84 LAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPEL 163
Cdd:TIGR02991  82 LAYAAAEEGVRATICMSELVPQNKVDEIRRLGAEVRIVGRSQDDAQEEVERLVADRGLTMLPPFDHPDIVAGQGTLGLEV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 164 LQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRTLIGEPN--- 240
Cdd:TIGR02991 162 VEQMPDLATVLVPLSGGGLASGVAMAVKAARPDTRVIGVSMERGAAMKASLQAGRPVLVAELPTLADSLGGGIGLDNrvt 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 241 FHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVgAVITGGNVDLDA 310
Cdd:TIGR02991 242 FAMCKALLDEIVLVSEAEIAAGIRHAYAEEREIVEGAGAVGIAALLAGKIKNPGPCA-VIVSGRNIDMDL 310
PRK06110 PRK06110
threonine dehydratase;
1-311 2.54e-45

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 156.31  E-value: 2.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   1 MLPSFAEIRDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEE-AARGVVTHSSGN 79
Cdd:PRK06110    1 MMFTLAELEAAAAVVYAAMPPTPQYRWPLLAERLGCEVWVKHENHTPTGAFKVRGGLVYFDRLARRGpRVRGVISATRGN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  80 HGNALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVmAGQGTL 159
Cdd:PRK06110   81 HGQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAELIEHGEDFQAAREEAARLAAERGLHMVPSFHPDLV-RGVATY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 160 VPELLQQAPGIDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRTLIGEP 239
Cdd:PRK06110  160 ALELFRAVPDLDVVYVPIGMGSGICGAIAARDALGLKTRIVGVVSAHAPAYALSFEAGRVVTTPVATTLADGMACRTPDP 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2674045042 240 N-FHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRYPAHFSGRNVGAVITGGNVDLDAL 311
Cdd:PRK06110  240 EaLEVIRAGADRIVRVTDDEVAAAMRAYFTDTHNVAEGAGAAALAAALQERERLAGKRVGLVLSGGNIDRAVF 312
PLN02550 PLN02550
threonine dehydratase
 33-311 8.53e-39

threonine dehydratase


Pssm-ID: 178165 [Multi-domain]  Cd Length: 591  Bit Score: 144.29  E-value: 8.53e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  33 RVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNALAMAARTRGIAAHVVVPEGAVKAKVDAII 112
Cdd:PLN02550  121 RLGVKVLLKREDLQPVFSFKLRGAYNMMAKLPKEQLDKGVICSSAGNHAQGVALSAQRLGCDAVIAMPVTTPEIKWQSVE 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 113 AAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELLQQAPG-IDTILFPVGGGGLAAGCSIAAH 191
Cdd:PLN02550  201 RLGATVVLVGDSYDEAQAYAKQRALEEGRTFIPPFDHPDVIAGQGTVGMEIVRQHQGpLHAIFVPVGGGGLIAGIAAYVK 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 192 GIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTICDGLRT-LIGEPNFHALRDHQVRVLRVSDDDVVAAMRLMWTEL 270
Cdd:PLN02550  281 RVRPEVKIIGVEPSDANAMALSLHHGERVMLDQVGGFADGVAVkEVGEETFRLCRELVDGVVLVSRDAICASIKDMFEEK 360

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2674045042 271 RVIVEPSSATTLAAMLRYPAHFS--GRNVGAVITGGNVDLDAL 311
Cdd:PLN02550  361 RSILEPAGALALAGAEAYCKYYGlkDENVVAITSGANMNFDRL 403
PRK08813 PRK08813
threonine dehydratase; Provisional
 4-311 1.93e-36

threonine dehydratase; Provisional


Pssm-ID: 236339 [Multi-domain]  Cd Length: 349  Bit Score: 133.60  E-value: 1.93e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   4 SFAEIRDAAARIAPHARVTPAMRSElidaRVGaaVWFKCENLQRGGAFKFRGATNAVWSLTDEEAARGVVTHSSGNHGNA 83
Cdd:PRK08813   22 SVADVLAAQARLRRYLSPTPLHYAE----RFG--VWLKLENLQRTGSYKVRGALNALLAGLERGDERPVICASAGNHAQG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  84 LAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPEL 163
Cdd:PRK08813   96 VAWSAYRLGVQAITVMPHGAPQTKIAGVAHWGATVRQHGNSYDEAYAFARELADQNGYRFLSAFDDPDVIAGQGTVGIEL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 164 LQQAPgiDTILFPVGGGGLAAGCSIAAHgiDPAIALFGAEPEGADDAARSLEADARvgPFTP-STICDGLRTLIgePNFH 242
Cdd:PRK08813  176 AAHAP--DVVIVPIGGGGLASGVALALK--SQGVRVVGAQVEGVDSMARAIRGDLR--EIAPvATLADGVKVKI--PGFL 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2674045042 243 ALR---DHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRypahFSGRNVGAVITGGNVDLDAL 311
Cdd:PRK08813  248 TRRlcsSLLDDVVIVREAELRETLVRLALEEHVIAEGAGALALAAGRR----VSGKRKCAVVSGGNIDATVL 315
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
 21-311 1.11e-31

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


Pssm-ID: 107209  Cd Length: 316  Bit Score: 120.10  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  21 VTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTDEEAA--RGVVTHSSGNHGNALAMAARTRGIAAHVV 98
Cdd:cd06448     1 KTPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGLNecVHVVCSSGGNAGLAAAYAARKLGVPCTIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  99 VPEGAVKAKVDAIIAAGATIHRCAATT-QAREAKAAEIMAATGANL-VHPYADARVMAGQGTLVPELLQQ---APGIDTI 173
Cdd:cd06448    81 VPESTKPRVVEKLRDEGATVVVHGKVWwEADNYLREELAENDPGPVyVHPFDDPLIWEGHSSMVDEIAQQlqsQEKVDAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 174 LFPVGGGGLAAGcsiAAHGIDPA----IALFGAEPEGADDAARSLEADARVgPFTPST-ICDGLRTL-IGEPNFHALRDH 247
Cdd:cd06448   161 VCSVGGGGLLNG---IVQGLERNgwgdIPVVAVETEGAHSLNASLKAGKLV-TLPKITsVATSLGAKtVSSQALEYAQEH 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2674045042 248 QVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAA-----MLRYPAHF---SGRNVGAVITGGN----VDLDAL 311
Cdd:cd06448   237 NIKSEVVSDRDAVQACLRFADDERILVEPACGAALAVvysgkILDLQLEVlltPLDNVVVVVCGGSnitlEQLKEY 312
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ...
 2-288 3.19e-29

Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 440264 [Multi-domain]  Cd Length: 394  Bit Score: 114.91  E-value: 3.19e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042   2 LPSFAEI---RDAAARIAPHARVTPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVwSLTDEEAARGVVTHSSG 78
Cdd:COG0498    44 LWRYRELlpfDDEEKAVSLGEGGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDRAMQVAV-SLALERGAKTIVCASSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  79 NHGNALA-MAARTrGIAAHVVVPEGAV-KAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATG---ANLVHPYadaRVM 153
Cdd:COG0498   123 NGSAALAaYAARA-GIEVFVFVPEGKVsPGQLAQMLTYGAHVIAVDGNFDDAQRLVKELAADEGlyaVNSINPA---RLE 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 154 aGQGTLVPELLQQ---APgiDTILFPVGGGGLAAGCSIA-----AHGIDPAI-ALFGAEPEGADDAARSLEA-DARVGPF 223
Cdd:COG0498   199 -GQKTYAFEIAEQlgrVP--DWVVVPTGNGGNILAGYKAfkelkELGLIDRLpRLIAVQATGCNPILTAFETgRDEYEPE 275

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 224 TPSTICDGLRtlIGEP-NF----HALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRY 288
Cdd:COG0498   276 RPETIAPSMD--IGNPsNGeralFALRESGGTAVAVSDEEILEAIRLLARREGIFVEPATAVAVAGLRKL 343
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
 22-288 2.11e-28

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 111.53  E-value: 2.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAA-VWFKCENLQRGGAFKFRGATNAVwSLTDEEAARGVVTHSSGNHGNALAMAARTRGIAAHVVVP 100
Cdd:cd01563    23 TPLVRAPRLGERLGGKnLYVKDEGLNPTGSFKDRGMTVAV-SKAKELGVKAVACASTGNTSASLAAYAARAGIKCVVFLP 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 101 EGAVKAKVDAIIAAGATIH-----RCAATTQAREAKAAEIMAAtgANLVHPYadaRVmAGQGTLVPELLQQ----APgiD 171
Cdd:cd01563   102 AGKALGKLAQALAYGATVLavegnFDDALRLVRELAEENWIYL--SNSLNPY---RL-EGQKTIAFEIAEQlgweVP--D 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 172 TILFPVGGGGLAAG-----CSIAAHG-IDPAIALFGAEPEGADDAARSLEA-DARVGPFT-PSTICDGLRtlIGEP---- 239
Cdd:cd01563   174 YVVVPVGNGGNITAiwkgfKELKELGlIDRLPRMVGVQAEGAAPIVRAFKEgKDDIEPVEnPETIATAIR--IGNPasgp 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2674045042 240 -NFHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRY 288
Cdd:cd01563   252 kALRAVRESGGTAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGLKKL 301
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 22-288 6.07e-22

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 93.35  E-value: 6.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVwsltdEEA-ARGVVTH-------SSGNHGNALAMAARTRGI 93
Cdd:cd01561     3 TPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMI-----EDAeKRGLLKPgttiiepTSGNTGIGLAMVAAAKGY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  94 AAHVVVPEGAVKAKVDAIIAAGATIHRCAAT----TQAREAKAAEiMAATGANLVHP--YA-DARVMAGQGTLVPELLQQ 166
Cdd:cd01561    78 RFIIVMPETMSEEKRKLLRALGAEVILTPEAeadgMKGAIAKARE-LAAETPNAFWLnqFEnPANPEAHYETTAPEIWEQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 167 APG-IDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGAddaarsleADARVGPFTPSTIcDGLRTLIGEPNF-HAL 244
Cdd:cd01561   157 LDGkVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGS--------VLFSGGPPGPHKI-EGIGAGFIPENLdRSL 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2674045042 245 RDhqvRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRY 288
Cdd:cd01561   228 ID---EVVRVSDEEAFAMARRLAREEGLLVGGSSGAAVAAALKL 268
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 22-288 2.95e-19

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 85.87  E-value: 2.95e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAAVWFKCENLQRGGAFKFRgatnAVWSLTDEEAARGVVTH-------SSGNHGNALAMAARTRGIA 94
Cdd:COG0031    14 TPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDR----IALSMIEDAEKRGLLKPggtiveaTSGNTGIGLAMVAAAKGYR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  95 AHVVVPEGAVKAKVDAIIAAGATIHRC--AATTQAREAKAAEIMAATGaNLVHP--YA-DARVMAGQGTLVPELLQQAPG 169
Cdd:COG0031    90 LILVMPETMSKERRALLRAYGAEVVLTpgAEGMKGAIDKAEELAAETP-GAFWPnqFEnPANPEAHYETTGPEIWEQTDG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 170 -IDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEGaddaarsleadarvgpftpSTICDGlrtliGEPNFHALR--- 245
Cdd:COG0031   169 kVDAFVAGVGTGGTITGVGRYLKERNPDIKIVAVEPEG-------------------SPLLSG-----GEPGPHKIEgig 224

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2674045042 246 --------DHQV--RVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLRY 288
Cdd:COG0031   225 agfvpkilDPSLidEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRL 277
thrC TIGR00260
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ...
 18-287 2.04e-15

threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 272986 [Multi-domain]  Cd Length: 327  Bit Score: 75.50  E-value: 2.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  18 HARVTPAMRSELIDARVGAA-VWFKCENLQRGGAFKFRGATNAVwSLTDEEAARGVVTHSSGNHGNALAMAARTRGIAAH 96
Cdd:TIGR00260  19 GEGVTPLFRAPALAANVGIKnLYVKELGHNPTLSFKDRGMAVAL-TKALELGNDTVLCASTGNTGAAAAAYAGKAGLKVV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  97 VVVPEGAV-KAKVDAIIAAGATIHRC-----AATTQARE-AKAAEIMAATGANLVhPYadaRVmAGQGTLVPELLQQAPG 169
Cdd:TIGR00260  98 VLYPAGKIsLGKLAQALGYNAEVVAIdgnfdDAQRLVKQlFEDKPALGLNSANSI-PY---RL-EGQKTYAFEAVEQLGW 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 170 I--DTILFPVGGGG-----LAAGCSIAAHGIDPAIALFGAEPEGADDAARSLEADARVGPF-TPSTICDGLRtlIGEPNf 241
Cdd:TIGR00260 173 EapDKVVVPVPNSGnfgaiWKGFKEKKMLGLDSLPVKRGIQAEGAADIVRAFLEGGQWEPIeTPETLSTAMD--IGNPA- 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2674045042 242 halrdHQVRVLR-----------VSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLR 287
Cdd:TIGR00260 250 -----NWPRALEafrrsngyaedLSDEEILEAIKLLAREEGYFVEPHSAVAVAALLK 301
PRK08329 PRK08329
threonine synthase; Validated
 17-285 7.44e-14

threonine synthase; Validated


Pssm-ID: 236244 [Multi-domain]  Cd Length: 347  Bit Score: 71.01  E-value: 7.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  17 PHARVTPAmrselidARVGAAVWFKCENLQRGGAFKFRGATNAVWSLTdEEAARGVVTHSSGNHGNALAMAARTRGIAAH 96
Cdd:PRK08329   60 LTPPITPT-------VKRSIKVYFKLDYLQPTGSFKDRGTYVTVAKLK-EEGINEVVIDSSGNAALSLALYSLSEGIKVH 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  97 VVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELLQQAPGIDTILFP 176
Cdd:PRK08329  132 VFVSYNASKEKISLLSRLGAELHFVEGDRMEVHEEAVKFSKRNNIPYVSHWLNPYFLEGTKTIAYEIYEQIGVPDYAFVP 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 177 VGGGGLAAGC------SIAAHGIDPAIALFGAEPEGADD-AARSLEAdarvgpftpSTICDGLRtlIGEPN-----FHAL 244
Cdd:PRK08329  212 VGSGTLFLGIwkgfkeLHEMGEISKMPKLVAVQAEGYESlCKRSKSE---------NKLADGIA--IPEPPrkeemLRAL 280

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2674045042 245 RDHQVRVLRVSDDDVVAAMrlmwTELR---VIVEPSSATTLAAM 285
Cdd:PRK08329  281 EESNGFCISVGEEETRAAL----HWLRrmgFLVEPTSAVALAAY 320
PRK08197 PRK08197
threonine synthase; Validated
 22-285 4.29e-13

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 69.26  E-value: 4.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAA-VWFKCENLQRGGAFKFRGATNAVwSLTDEEAARGVVTHSSGNHGNALAMAARTRGIAAHVVVP 100
Cdd:PRK08197   80 TPLLPLPRLGKALGIGrLWVKDEGLNPTGSFKARGLAVGV-SRAKELGVKHLAMPTNGNAGAAWAAYAARAGIRATIFMP 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 101 EGAVKAKVDAIIAAGAT-------IHRCAAttQAREAKAAEIMAATgANLVHPYadaRVmAGQGTLVPELLQQ----APg 169
Cdd:PRK08197  159 ADAPEITRLECALAGAElylvdglISDAGK--IVAEAVAEYGWFDV-STLKEPY---RI-EGKKTMGLELAEQlgwrLP- 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 170 iDTILFPVGGG-GLAagcsiaahGIDPAIA--------------LFGAEPEGADDAARSLEADARVGPFTP--STICDGL 232
Cdd:PRK08197  231 -DVILYPTGGGvGLI--------GIWKAFDelealgwiggkrprLVAVQAEGCAPIVKAWEEGKEESEFWEdaHTVAFGI 301

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2674045042 233 RTLIGEPNF---HALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAM 285
Cdd:PRK08197  302 RVPKALGDFlvlDAVRETGGCAIAVSDDAILAAQRELAREEGLFACPEGAATFAAA 357
PRK05638 PRK05638
threonine synthase; Validated
 14-303 8.45e-13

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 68.30  E-value: 8.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  14 RIAPHARVTPAMRSELIDaRVGAAVWFKCENLQRGGAFKFRGATNAVwSLTDEEAARGVVTHSSGNHGNALAMAARTRGI 93
Cdd:PRK05638   59 IISLGEGGTPLIRARISE-KLGENVYIKDETRNPTGSFRDRLATVAV-SYGLPYAANGFIVASDGNAAASVAAYSARAGK 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  94 AAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHPYADARVMAGQGTLVPELLQQApGIDTI 173
Cdd:PRK05638  137 EAFVVVPRKVDKGKLIQMIAFGAKIIRYGESVDEAIEYAEELARLNGLYNVTPEYNIIGLEGQKTIAFELWEEI-NPTHV 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 174 LFPVGGG--------GLAAGCSIAAhgIDPAIALFGAEPEGADDAARSLEADARVGPFTPSTicdGL---RTLIGEPNFH 242
Cdd:PRK05638  216 IVPTGSGsylysiykGFKELLEIGV--IEEIPKLIAVQTERCNPIASEILGNKTKCNETKAL---GLyvkNPVMKEYVSE 290

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674045042 243 ALRDHQVRVLRVSDDDVVAAMRLMWTElRVIVEPSSATTLAAMLRY---PAHFSGRNVGAVITG 303
Cdd:PRK05638  291 AIKESGGTAVVVNEEEIMAGEKLLAKE-GIFAELSSAVVMPALLKLgeeGYIEKGDKVVLVVTG 353
PRK08206 PRK08206
diaminopropionate ammonia-lyase; Provisional
 72-287 2.39e-12

diaminopropionate ammonia-lyase; Provisional


Pssm-ID: 236186  Cd Length: 399  Bit Score: 66.83  E-value: 2.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  72 VVTHSSGNHGNALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAATTQAREAKAAEIMAATGANLVHP----- 146
Cdd:PRK08206  119 FATATDGNHGRGVAWAAQQLGQKAVIYMPKGSSEERVDAIRALGAECIITDGNYDDSVRLAAQEAQENGWVVVQDtaweg 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 147 YAD--ARVMAGQGTLVPELLQQAPGID---TILFPVGG-GGLAAGcsIAAHGIDpaiaLFGA--------EPEGADDAAR 212
Cdd:PRK08206  199 YEEipTWIMQGYGTMADEAVEQLKEMGvppTHVFLQAGvGSLAGA--VLGYFAE----VYGEqrphfvvvEPDQADCLYQ 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 213 SleadARVGpfTPSTICDGLRTLI-----GEPNFHA---LRDHQVRVLRVSDDDVVAAMRLMWTEL----RVIVEPSSAT 280
Cdd:PRK08206  273 S----AVDG--KPVAVTGDMDTIMaglacGEPNPLAweiLRNCADAFISCPDEVAALGMRILANPLggdpPIVSGESGAV 346


                  ....*..
gi 2674045042 281 TLAAMLR 287
Cdd:PRK08206  347 GLGALAA 353
cysKM TIGR01136
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ...
 22-287 1.85e-10

cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273463  Cd Length: 299  Bit Score: 60.76  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVWsltDEEAaRGVVTH-------SSGNHGNALAMAARTRGIA 94
Cdd:TIGR01136   8 TPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMIL---DAEK-RGLLKPgdtiieaTSGNTGIALAMVAAARGYK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  95 AHVVVPEGAVKAKVDAIIAAGATIhrcaATTQARE------AKAAEIMAATG--------ANLVHPYADarvmagQGTLV 160
Cdd:TIGR01136  84 LILTMPETMSLERRKLLRAYGAEL----ILTPGEEgmkgaiDKAEELAAETNkyvmldqfENPANPEAH------YKTTG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 161 PELLQQAPG-IDTILFPVGGGGLAAGCSIAAHGIDPAIALFGAEPEgaddaarslEADARVGpftpsticdglrtliGEP 239
Cdd:TIGR01136 154 PEIWRDTDGrIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPA---------ESPVLSG---------------GEP 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2674045042 240 NFHALR-----------DHQV--RVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAAMLR 287
Cdd:TIGR01136 210 GPHKIQgigagfipkilDLSLidEVITVSDEDAIETARRLAREEGILVGISSGAAVAAALK 270
PRK06450 PRK06450
threonine synthase; Validated
 38-289 3.42e-09

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 57.05  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  38 VWFKCENLQRGGAFKFRGATNAVWSLTDEEAARgVVTHSSGNHGNALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGAT 117
Cdd:PRK06450   67 IWFKLDFLNPTGSYKDRGSVTLISYLAEKGIKQ-ISEDSSGNAGASIAAYGAAAGIEVKIFVPETASGGKLKQIESYGAE 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 118 IHRCAATtqaRE--AKAAEIMAATGANLV-HP-YADA-RVMAGQgtLVPELLQQAPgiDTILFPVGGGGLAAG------- 185
Cdd:PRK06450  146 VVRVRGS---REdvAKAAENSGYYYASHVlQPqFRDGiRTLAYE--IAKDLDWKIP--NYVFIPVSAGTLLLGvysgfkh 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 186 -------------CSIAAHGIDPAIALFGAEPEGADDAARSLeADARVGPftpsticdglrtligEPnfhALRDHQVRVL 252
Cdd:PRK06450  219 lldsgvisempkiVAVQTEQVSPLCAKFKGISYTPPDKVTSI-ADALVST---------------RP---FLLDYMVKAL 279

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2674045042 253 R-------VSDDDVVAAmrlmWTELR---VIVEPSSATTLAAMLRYP 289
Cdd:PRK06450  280 SeygecivVSDNEIVEA----WKELAkkgLLVEYSSATVYAAYKKYS 322
PRK06381 PRK06381
threonine synthase; Validated
 71-304 1.18e-07

threonine synthase; Validated


Pssm-ID: 235789  Cd Length: 319  Bit Score: 52.40  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  71 GVVTHSSGNHGNALAMAARTRGIAAHVVVPEGAVKAKVDAIIAAGATIHRCAAT---TQAREAKAAEIMAATGAN--LVH 145
Cdd:PRK06381   65 GITVGTCGNYGASIAYFARLYGLKAVIFIPRSYSNSRVKEMEKYGAEIIYVDGKyeeAVERSRKFAKENGIYDANpgSVN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 146 PYADarvMAGQGTLVPELLQQ---APgiDTILFPVGGGGLAAGCSiaaHG---------IDPAIALFGAEPEGADDAARS 213
Cdd:PRK06381  145 SVVD---IEAYSAIAYEIYEAlgdVP--DAVAVPVGNGTTLAGIY---HGfrrlydrgkTSRMPRMIGVSTSGGNQIVES 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042 214 LE------ADARVGPFTPSTICDGL---RTLIGEPNFHALRDHQVRVLRVSDDDVVAAMRLMWTELRVIVEPSSATTLAA 284
Cdd:PRK06381  217 FKrgssevVDLEVDEIRETAVNEPLvsyRSFDGDNALEAIYDSHGYAFGFSDDEMVKYAELLRRMEGLNALPASASALAA 296

                         250       260
                  ....*....|....*....|.
gi 2674045042 285 MLRYPAHFS-GRNVGAVITGG 304
Cdd:PRK06381  297 LVKYLKKNGvNDNVVAVITGR 317
PLN02356 PLN02356
phosphateglycerate kinase
 22-120 1.39e-05

phosphateglycerate kinase


Pssm-ID: 215204  Cd Length: 423  Bit Score: 46.14  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVwsltdEEAAR-------GVVTH-SSGNHGNALAMAARTRGI 93
Cdd:PLN02356   54 TPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKII-----EEALEsgqlfpgGVVTEgSAGSTAISLATVAPAYGC 128

                          90       100
                  ....*....|....*....|....*..
gi 2674045042  94 AAHVVVPEGAVKAKVDAIIAAGATIHR 120
Cdd:PLN02356  129 KCHVVIPDDVAIEKSQILEALGATVER 155
cysM PRK11761
cysteine synthase CysM;
22-118 3.02e-04

cysteine synthase CysM;


Pssm-ID: 236972  Cd Length: 296  Bit Score: 41.78  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674045042  22 TPAMRSELIDARVGAAVWFKCENLQRGGAFKFRGATNAVwsltdEEA-ARG-------VVTHSSGNHGNALAMAARTRGI 93
Cdd:PRK11761   13 TPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMI-----VQAeKRGeikpgdtLIEATSGNTGIALAMIAAIKGY 87

                          90       100
                  ....*....|....*....|....*
gi 2674045042  94 AAHVVVPEGAVKAKVDAIIAAGATI 118
Cdd:PRK11761   88 RMKLIMPENMSQERRAAMRAYGAEL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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