|
Name |
Accession |
Description |
Interval |
E-value |
| Cas1 |
COG1518 |
CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated ... |
195-525 |
5.25e-107 |
|
CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated integrase Cas1 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 441127 Cd Length: 329 Bit Score: 322.53 E-value: 5.25e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPPPH-K 273
Cdd:COG1518 2 LYITEPGAYLSRKGNTLVVEKEDEEKKRVPLEDIEQIVLFGEVSLSTALLRFLAENGIPVHFLDYYGRYLGRLLPRESgG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 274 HIDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPAGVLERLAA---ARRRAERAKSLEQLLGIEGYAAR 350
Cdd:COG1518 82 NVLLRRAQYQAYLDEEKRLALARSIVRGKIRNQRAVLRRYGRRRKEDLEEAIERleeLLKRLEEADSIDELRGIEGNAAR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 351 DYFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNalllflyalltkeMLI-------------TLVGVGFDPYLGFYH 417
Cdd:COG1518 162 IYFSALDGLLPED-------FRFEGRSRRPPRDPVN-------------ALLsfgytllysdvlsAIYAAGLDPYIGFLH 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 418 QPKYGRPALALDLMEEFRPLIADSVAIGLINNGELRPSDFIARAGAVALTDNGRRRVLDAYERRLDTLVTHPRFGYAISY 497
Cdd:COG1518 222 EPRPGRPSLALDLMEEFRPILVDRLVLSLINRGQITPKDFEKELGGVLLTEEGRKKFLEAFEERLQETIKHPFLGRKVSY 301
|
330 340
....*....|....*....|....*...
gi 2707155935 498 RRIFEVQARLLARFLLGEIAEYPAFYTR 525
Cdd:COG1518 302 RRLIRLQARKLAKHLRGELDEYPPFVLR 329
|
|
| Cas1_I-II-III |
cd09634 |
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ... |
195-514 |
9.18e-95 |
|
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain
Pssm-ID: 187766 Cd Length: 317 Bit Score: 290.67 E-value: 9.18e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPP-PHK 273
Cdd:cd09634 3 LYITTPGAYLSRKGNRLVVEKEDEKKKRIPLEDIDSIVIFGNVSISTAALRLLAENGIPVHFLDYYGRYLGRLYPPeGGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 274 HIDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPAGVLERLAAARRRAERAK--SLEQLLGIEGYAARD 351
Cdd:cd09634 83 SVLLRRAQYEAYLDPEKRLELAREIVRGKIRNQRRVLKRYARDGKELLLALAELEELLEKLDKakSIEELRGIEGNAAKI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 352 YFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNALLLFLYALLTKEMLITLVGVGFDPYLGFYHQPKYGRPALALDLM 431
Cdd:cd09634 163 YFEALFQLLPKE-------FRFEGRSRRPPKDPVNALLSYGYSLLYSAVLSAIVAAGLDPYIGFLHEDRPGRPSLALDLM 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 432 EEFRPLIADSVAIGLINNGELRPSDFIARAGAVALTDNGRRRVLDAYERRLDTLVTHpRFGYAISYRRIFEVQARLLARF 511
Cdd:cd09634 236 EEFRPIIVDRLVLSLINKGQIKKKDFEKELGGVLLTEEGRKKLIEALEERLKETIKH-YLGRKVSYRRLIRLQAYKLAKH 314
|
...
gi 2707155935 512 LLG 514
Cdd:cd09634 315 LRG 317
|
|
| Cas_Cas1 |
pfam01867 |
CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats ... |
195-480 |
1.29e-93 |
|
CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.
Pssm-ID: 460366 Cd Length: 283 Bit Score: 286.66 E-value: 1.29e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPPPHKH 274
Cdd:pfam01867 1 LYVTTPGAYLSRKGETLVVEKEGEEKKRIPLEDVEQIVIFGNVSISTAALRLLAERGIPVHFLSYYGRYLGRLYPEVSGN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 275 IDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPAGVLERL----AAARRRAERAKSLEQLLGIEGYAAR 350
Cdd:pfam01867 81 VLLRRAQYRAYDDEEKRLELARSFVAGKLRNQRTVLRRYNRDRKDEALEEAieelEELLKKLERADSIDELRGIEGNAAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 351 DYFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNalllflyallTKEMLITLVGVGFDPYLGFYHQPKYGRPALALDL 430
Cdd:pfam01867 161 AYFSAFDELLPKE-------FGFEGRSRRPPLDPVNallsfgytllYSDVLSALEAVGLDPYIGFLHEDRPGRPSLALDL 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2707155935 431 MEEFRPLIADSVAIGLINNGELRPSDFIARAGAVALTDNGRRRVLDAYER 480
Cdd:pfam01867 234 MEEFRPVIVDRLVLSLINRGQITPKDFEKRENGVLLNDEGRKKFLKAYEE 283
|
|
| cas1_CYANO |
TIGR04093 |
CRISPR-associated endonuclease Cas1, subtype CYANO; The CRISPR-associated protein Cas1 is ... |
195-525 |
2.79e-81 |
|
CRISPR-associated endonuclease Cas1, subtype CYANO; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.
Pssm-ID: 274976 Cd Length: 323 Bit Score: 256.20 E-value: 2.79e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGE---VLEIRSKGAVVSeARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPPP 271
Cdd:TIGR04093 3 LYITQPDAKISKDDGriiVVDSDGEEKVAS-FPLIKVETIVVFGEATLTTPALAHLLERGIVLHYLTRFGKYFGSLVPEL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 272 HKHIDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGlpagvLERLAAARRRAERAKSLEQLLGIEGYAARD 351
Cdd:TIGR04093 82 TRNTILRVAQHQAHISPQQRLAIAREIVRGKLRNSRTMLYRRGRK-----QTKIPELEKPVDDKNSLDSLRGLEGEAAAI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 352 YFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNALLLFLYALLTKEMLITLVGVGFDPYLGFYHQPKYGRPALALDLM 431
Cdd:TIGR04093 157 YFGCLSDLLPDE-------WSFHGRTRRPPTDPVNALLSLGYALLRTQVLSALRIVGLDPYIGFLHVDRHGRPALALDLM 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 432 EEFRPLIADSVAIGLINNGELRPSDFIARAGAVALTDNGRRRVLDAYERRLDTLVTHPRFGYAISYRRIFEVQARLLARF 511
Cdd:TIGR04093 230 EEFRPIIVDAVVLRLINRKMLKPKDFQEEPGAVRLKDEAFKLFLGKFEEKMQSEFKHPIFKYKVSYRRAIELQARLLAKA 309
|
330
....*....|....
gi 2707155935 512 LLGEIAEYPAFYTR 525
Cdd:TIGR04093 310 LMGEIKEYPPLIIR 323
|
|
| Cas4 |
COG1468 |
CRISPR/Cas system-associated exonuclease Cas4, RecB family [Defense mechanisms]; CRISPR/Cas ... |
16-158 |
1.30e-32 |
|
CRISPR/Cas system-associated exonuclease Cas4, RecB family [Defense mechanisms]; CRISPR/Cas system-associated exonuclease Cas4, RecB family is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 441077 [Multi-domain] Cd Length: 184 Bit Score: 123.15 E-value: 1.30e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 16 EALDSMPELHARSVMAGSDTLGAVARIDVIEGEHEHVVPVDYKRGTPpdipeRAYEPERVQLCLQGLLLREQ-GYPCTHG 94
Cdd:COG1468 46 ERVYKRLERLRREVPLDSERLGLTGKIDLVEFEDGELVPVEYKKSKP-----KPWEADRMQLCAYALLLEEMlGIPVPKG 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2707155935 95 ILYFAASQTRVTVEFTEALQARTLELLAEARHTAAAGESPPPLVESPKCPRCSLVGICLPDEVN 158
Cdd:COG1468 121 YLYYPEERKREEVELTEELREEVEEAIEEIREILESEKPPPPTKSKKKCKKCSYREFCLPRETS 184
|
|
| cas4 |
TIGR00372 |
CRISPR-associated protein Cas4; This model represents a family of proteins associated with ... |
27-154 |
6.74e-18 |
|
CRISPR-associated protein Cas4; This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.
Pssm-ID: 273040 [Multi-domain] Cd Length: 178 Bit Score: 81.30 E-value: 6.74e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 27 RSVMAGSDTLGAVARIDVIEGEHEHVVPVDYKRGTPPdiPERAYepeRVQLCLQGLLLREQGYPCTHGILYFAASQTRVT 106
Cdd:TIGR00372 56 KEVPLKSKKYGLKGVIDIVLEEDGELVPVEVKSGKPS--PREAH---KYQLLAYAYLLEEMYGEIVRGYILYINAGKKLE 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2707155935 107 VEFTEALQARTLELLAEARHTAAAGESPPPLVESPKCPRCSLVGICLP 154
Cdd:TIGR00372 131 VEISEELRKKAVKLIEKIRELLEGGKPPSPPKSGPKCKFCPYREICLP 178
|
|
| Cas4_I-A_I-B_I-C_I-D_II-B |
cd09637 |
CRISPR/Cas system-associated protein Cas4; CRISPR (Clustered Regularly Interspaced Short ... |
27-153 |
3.41e-16 |
|
CRISPR/Cas system-associated protein Cas4; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster
Pssm-ID: 187768 [Multi-domain] Cd Length: 178 Bit Score: 76.70 E-value: 3.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 27 RSVMAGSDTLGAVARIDVIEGEHEHVVPVDYKRGtPPDIPERAYepeRVQLCLQGLLLREQ-GYPCTHGILYFAASQTRV 105
Cdd:cd09637 56 KEVPLKSKKYGLKGVIDIVLKEDGELVPVEVKSG-RAGSPREAH---KLQLVAYAYLLEEMyGKRVARGYIVYLEGGKRL 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2707155935 106 TVEFTEALQARTLELLAEARhTAAAGESPPPLVESPKCPRCSLVGICL 153
Cdd:cd09637 132 EVEISEELRKKAEKLLEEIR-KLLEGELPPPVKSSPKCKFCPYREICL 178
|
|
| Cas_Cas4 |
pfam01930 |
Domain of unknown function DUF83; This domain has no known function. The domain contains three ... |
41-154 |
2.62e-14 |
|
Domain of unknown function DUF83; This domain has no known function. The domain contains three conserved cysteines at its C terminus.
Pssm-ID: 426517 [Multi-domain] Cd Length: 160 Bit Score: 70.72 E-value: 2.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 41 RIDVIEGEHEHVVPVDYKRGTPPDiperayEPERVQLCLQGLLLREQGYPCThGILYFAASQTRVTVEFTEALQARTLEL 120
Cdd:pfam01930 55 KIDFVRRRGGGLVVHEVKKSSKME------EAHRMQLLYYLYYLKKRGIEIK-GVLHYPKERKREEVELTEEDRRELEEA 127
|
90 100 110
....*....|....*....|....*....|....
gi 2707155935 121 LAEARHtAAAGESPPPLVESPKCPRCSLVGICLP 154
Cdd:pfam01930 128 IKEIEE-IISSEKPPPPQKKKICKKCAYYEFCWP 160
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Cas1 |
COG1518 |
CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated ... |
195-525 |
5.25e-107 |
|
CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated integrase Cas1 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 441127 Cd Length: 329 Bit Score: 322.53 E-value: 5.25e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPPPH-K 273
Cdd:COG1518 2 LYITEPGAYLSRKGNTLVVEKEDEEKKRVPLEDIEQIVLFGEVSLSTALLRFLAENGIPVHFLDYYGRYLGRLLPRESgG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 274 HIDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPAGVLERLAA---ARRRAERAKSLEQLLGIEGYAAR 350
Cdd:COG1518 82 NVLLRRAQYQAYLDEEKRLALARSIVRGKIRNQRAVLRRYGRRRKEDLEEAIERleeLLKRLEEADSIDELRGIEGNAAR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 351 DYFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNalllflyalltkeMLI-------------TLVGVGFDPYLGFYH 417
Cdd:COG1518 162 IYFSALDGLLPED-------FRFEGRSRRPPRDPVN-------------ALLsfgytllysdvlsAIYAAGLDPYIGFLH 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 418 QPKYGRPALALDLMEEFRPLIADSVAIGLINNGELRPSDFIARAGAVALTDNGRRRVLDAYERRLDTLVTHPRFGYAISY 497
Cdd:COG1518 222 EPRPGRPSLALDLMEEFRPILVDRLVLSLINRGQITPKDFEKELGGVLLTEEGRKKFLEAFEERLQETIKHPFLGRKVSY 301
|
330 340
....*....|....*....|....*...
gi 2707155935 498 RRIFEVQARLLARFLLGEIAEYPAFYTR 525
Cdd:COG1518 302 RRLIRLQARKLAKHLRGELDEYPPFVLR 329
|
|
| Cas1_I-II-III |
cd09634 |
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ... |
195-514 |
9.18e-95 |
|
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain
Pssm-ID: 187766 Cd Length: 317 Bit Score: 290.67 E-value: 9.18e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPP-PHK 273
Cdd:cd09634 3 LYITTPGAYLSRKGNRLVVEKEDEKKKRIPLEDIDSIVIFGNVSISTAALRLLAENGIPVHFLDYYGRYLGRLYPPeGGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 274 HIDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPAGVLERLAAARRRAERAK--SLEQLLGIEGYAARD 351
Cdd:cd09634 83 SVLLRRAQYEAYLDPEKRLELAREIVRGKIRNQRRVLKRYARDGKELLLALAELEELLEKLDKakSIEELRGIEGNAAKI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 352 YFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNALLLFLYALLTKEMLITLVGVGFDPYLGFYHQPKYGRPALALDLM 431
Cdd:cd09634 163 YFEALFQLLPKE-------FRFEGRSRRPPKDPVNALLSYGYSLLYSAVLSAIVAAGLDPYIGFLHEDRPGRPSLALDLM 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 432 EEFRPLIADSVAIGLINNGELRPSDFIARAGAVALTDNGRRRVLDAYERRLDTLVTHpRFGYAISYRRIFEVQARLLARF 511
Cdd:cd09634 236 EEFRPIIVDRLVLSLINKGQIKKKDFEKELGGVLLTEEGRKKLIEALEERLKETIKH-YLGRKVSYRRLIRLQAYKLAKH 314
|
...
gi 2707155935 512 LLG 514
Cdd:cd09634 315 LRG 317
|
|
| Cas_Cas1 |
pfam01867 |
CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats ... |
195-480 |
1.29e-93 |
|
CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.
Pssm-ID: 460366 Cd Length: 283 Bit Score: 286.66 E-value: 1.29e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPPPHKH 274
Cdd:pfam01867 1 LYVTTPGAYLSRKGETLVVEKEGEEKKRIPLEDVEQIVIFGNVSISTAALRLLAERGIPVHFLSYYGRYLGRLYPEVSGN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 275 IDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPAGVLERL----AAARRRAERAKSLEQLLGIEGYAAR 350
Cdd:pfam01867 81 VLLRRAQYRAYDDEEKRLELARSFVAGKLRNQRTVLRRYNRDRKDEALEEAieelEELLKKLERADSIDELRGIEGNAAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 351 DYFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNalllflyallTKEMLITLVGVGFDPYLGFYHQPKYGRPALALDL 430
Cdd:pfam01867 161 AYFSAFDELLPKE-------FGFEGRSRRPPLDPVNallsfgytllYSDVLSALEAVGLDPYIGFLHEDRPGRPSLALDL 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2707155935 431 MEEFRPLIADSVAIGLINNGELRPSDFIARAGAVALTDNGRRRVLDAYER 480
Cdd:pfam01867 234 MEEFRPVIVDRLVLSLINRGQITPKDFEKRENGVLLNDEGRKKFLKAYEE 283
|
|
| cas1_CYANO |
TIGR04093 |
CRISPR-associated endonuclease Cas1, subtype CYANO; The CRISPR-associated protein Cas1 is ... |
195-525 |
2.79e-81 |
|
CRISPR-associated endonuclease Cas1, subtype CYANO; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.
Pssm-ID: 274976 Cd Length: 323 Bit Score: 256.20 E-value: 2.79e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGE---VLEIRSKGAVVSeARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPPP 271
Cdd:TIGR04093 3 LYITQPDAKISKDDGriiVVDSDGEEKVAS-FPLIKVETIVVFGEATLTTPALAHLLERGIVLHYLTRFGKYFGSLVPEL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 272 HKHIDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGlpagvLERLAAARRRAERAKSLEQLLGIEGYAARD 351
Cdd:TIGR04093 82 TRNTILRVAQHQAHISPQQRLAIAREIVRGKLRNSRTMLYRRGRK-----QTKIPELEKPVDDKNSLDSLRGLEGEAAAI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 352 YFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNALLLFLYALLTKEMLITLVGVGFDPYLGFYHQPKYGRPALALDLM 431
Cdd:TIGR04093 157 YFGCLSDLLPDE-------WSFHGRTRRPPTDPVNALLSLGYALLRTQVLSALRIVGLDPYIGFLHVDRHGRPALALDLM 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 432 EEFRPLIADSVAIGLINNGELRPSDFIARAGAVALTDNGRRRVLDAYERRLDTLVTHPRFGYAISYRRIFEVQARLLARF 511
Cdd:TIGR04093 230 EEFRPIIVDAVVLRLINRKMLKPKDFQEEPGAVRLKDEAFKLFLGKFEEKMQSEFKHPIFKYKVSYRRAIELQARLLAKA 309
|
330
....*....|....
gi 2707155935 512 LLGEIAEYPAFYTR 525
Cdd:TIGR04093 310 LMGEIKEYPPLIIR 323
|
|
| Cas1_I-C |
cd09721 |
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ... |
195-522 |
4.47e-75 |
|
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain
Pssm-ID: 187852 Cd Length: 338 Bit Score: 240.60 E-value: 4.47e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPPPHKH 274
Cdd:cd09721 5 LYVTTQGTYLHKDGETVVVEVEGEKKARVPLHHLGGIVCFGNVGLSPFLMGRCAEDGISLVFLTENGRFLARVEGPVSGN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 275 IDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPAGVLERLAAARRRA--------ERAKSLEQLLGIEG 346
Cdd:cd09721 85 VLLRRAQYRAADDPERSLAIARSIVAGKIRNARQVLLRAARDHGEEDDRAALEAAADRlavalrrlQRADDLDELRGIEG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 347 YAARDYFAHFACMFKPgedeQAPAFEFTSRNRRPPRDPVNALLLFLYALLTKEMLITLVGVGFDPYLGFYHQPKYGRPAL 426
Cdd:cd09721 165 EAARLYFAVFDHLLRQ----DAPAFRFDGRSRRPPLDPVNALLSFLYTLLTHDCRSALEGVGLDPAVGFLHRDRPGRPSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 427 ALDLMEEFRPLIADSVAIGLINNGELRPSDFIARA-GAVALTDNGRRRVLDAYERRLDTLVTHPRFGYAISYRRIFEVQA 505
Cdd:cd09721 241 ALDLMEEFRAVLADRLALSLINRGQLTAKDFEVREgGAVLLTDDARKTVLVAYQERKQEEITHPFLGEKVPLGLLPHVQA 320
|
330
....*....|....*..
gi 2707155935 506 RLLARFLLGEIAEYPAF 522
Cdd:cd09721 321 RLLARHLRGDLDGYPPF 337
|
|
| cas1_DVULG |
TIGR03640 |
CRISPR-associated endonuclease Cas1, subtype I-C/DVULG; The CRISPR-associated protein Cas1 is ... |
195-522 |
6.60e-75 |
|
CRISPR-associated endonuclease Cas1, subtype I-C/DVULG; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.
Pssm-ID: 188360 Cd Length: 340 Bit Score: 240.22 E-value: 6.60e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGGWLSAITTPPPHKH 274
Cdd:TIGR03640 6 LYVTTQGTYLHKDGETVVVEVEGEKKARVPLHHLGGIVCFGNVGLSPFLMGRCAEDGISLVFLTENGRFLARVEGPVSGN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 275 IDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPAGVLERLAAARRRA--------ERAKSLEQLLGIEG 346
Cdd:TIGR03640 86 VLLRRAQYRAADDPERSLAIARSIVAGKIRNARQVLLRAARDHGEEDDAAALEAAADRlavalrrlQRADDLDSLRGIEG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 347 YAARDYFAHFACMFKPgedeQAPAFEFTSRNRRPPRDPVNALLLFLYALLTKEMLITLVGVGFDPYLGFYHQPKYGRPAL 426
Cdd:TIGR03640 166 EAARLYFAVFDHLLRQ----DRPAFRFDGRSRRPPLDPVNALLSFLYTLLTHDCRSALEGVGLDPAVGFLHRDRPGRPSL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 427 ALDLMEEFRPLIADSVAIGLINNGELRPSDFIARA-GAVALTDNGRRRVLDAYERRLDTLVTHPRFGYAISYRRIFEVQA 505
Cdd:TIGR03640 242 ALDLMEEFRAVLADRLALSLINRGQLTAKDFEVREgGAVLLTDDARKTVLVAYQERKQEEILHPFLGEKVPLGLLPHVQA 321
|
330
....*....|....*..
gi 2707155935 506 RLLARFLLGEIAEYPAF 522
Cdd:TIGR03640 322 RLLARHLRGDLDGYPPF 338
|
|
| cas1 |
TIGR00287 |
CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the ... |
195-520 |
9.50e-75 |
|
CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the most universal CRISPR system protein. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is a metal-dependent DNA-specific endonuclease.
Pssm-ID: 272998 Cd Length: 323 Bit Score: 239.17 E-value: 9.50e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGG-WLSAITTPPPHK 273
Cdd:TIGR00287 2 LYVLEYGSYLSRKGNTLVVEKEGKKKWNIPVANVDCIVLFGGVSISSAAIRLLAKRGIDIVFFGGDGnYVGRLSPQESGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 274 HIDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPA--GVLERLAAARRRAERAKSLEQLLGIEGYAARD 351
Cdd:TIGR00287 82 TVELRLAQVKAYLDEEKRLKLAKEFVSGKIANQAALLKYLTRRREDlrSYLEEYESLMKELASADSIEELMGIEGNAARA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 352 YFAHFACMFKPgedeqapAFEFTSRNRRPPRDPVNALLLFLYALLTKEMLITLVGVGFDPYLGFYHQPKYGRPALALDLM 431
Cdd:TIGR00287 162 YYAALAQLLPD-------EFGFNGRSKRPPKDPFNALLSYGYSLLYSNVLTAIYIAGLDPYIGFLHTDRSGRPSLVLDLM 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 432 EEFRPLIADSVAIGLINNGELRPSDFIARAGAVALTDNGRRRVLDAYERRLDTLVTHPRFGYAISYRRIFEVQARLLARF 511
Cdd:TIGR00287 235 EEFKPQIVDRLVFSLINRNIITEEDFEKISNGVYLGEEGRKKFLQAFEERLQTTVTHPGLNRRVSYLDIIILQARKLAKA 314
|
....*....
gi 2707155935 512 LLGEIAEYP 520
Cdd:TIGR00287 315 LRGEERYRP 323
|
|
| cas1_MYXAN |
TIGR03983 |
CRISPR-associated endonuclease Cas1, subtype MYXAN; Members of this protein are the Cas1 ... |
182-515 |
1.07e-58 |
|
CRISPR-associated endonuclease Cas1, subtype MYXAN; Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.
Pssm-ID: 274899 Cd Length: 347 Bit Score: 198.06 E-value: 1.07e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 182 PRRLVPARDDRRAVYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGG 261
Cdd:TIGR03983 1 PVRLFPEDDERQVLHVLEPGTRIGRTGEQLKVTRREGADEKIPIQQVSQVVLHGFSQISTQALHFLASEEIGVHWVSGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 262 -WLSAITTPPphKHIDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLPAGVLERLAAARRRAERAK---- 336
Cdd:TIGR03983 81 rYIGSFDGRS--GSVQRRIRQFRALTQEDFCLGLARKLVAAKGEGQLRFLLRAKRGDKESRPELESAIAQMRAVLKqveq 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 337 --SLEQLLGIEGYAARDYFAHFACMFKPGEDeqaPAFEFTSRNRRPPRDPVNALLLFLYALLTKEMLITLVGVGFDPYLG 414
Cdd:TIGR03983 159 aeSLESLLGIEGNLAALYFGALPALLGKDVD---DSLRFSGRNRRPPKDRFNALLSFGYSLLYKDVMNAILAVGLEPAFG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 415 FYHQPKYGRPALALDLMEEFRPLIADSVAIGLINNGELR-PSDFIARAGAVALTDNGRRRVLDAYERRLDTLVTHPRFGY 493
Cdd:TIGR03983 236 FYHQPRTQAPPLALDLMELFRVPLVDMPVVGSINRRQWDiDEDFEITGQQVWLSDSGRRKFIELYERRKAETWKHPVLGY 315
|
330 340
....*....|....*....|..
gi 2707155935 494 AISYRRIFEVQARLLARFLLGE 515
Cdd:TIGR03983 316 SLSYARLIELEVRLLEKEWSGE 337
|
|
| Cas1_I-II-III |
cd09636 |
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ... |
195-457 |
5.16e-52 |
|
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain
Pssm-ID: 187767 Cd Length: 260 Bit Score: 177.87 E-value: 5.16e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 195 VYVQRQGHSVGLKGEVLEIRSKGAVVSEARLLEMSQLSLFGNVQLTSQALRALAAREIPIVHLSYGG-WLSAITTPPPHK 273
Cdd:cd09636 1 LYVLEYGSYLSRKGNTLVVEKEGELKKNIPVANVDCIVIFGGVSISSAAIRELAKRGIDIVFLGGDGnYLGRLYPPEPGS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 274 HIDLRRRQFATAVDQAVYVSLARAFVAGKIRNTRTLLRRNSRGLP---AGVLERLAAARRRAERAKSLEQLLGIEGYAAR 350
Cdd:cd09636 81 SVFTRRAQYKAYLNPAKRLKLAREFVEGKLANQAALLRYLTRRREdlkSELAEYIAELLKELDNANSIEELMGIEGNAAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 351 DYFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNALLLFLYALLTKEMLITLVGVGFDPYLGFYHQPKYGRPALALDL 430
Cdd:cd09636 161 AYYAALAQLLPDE-------FGFNGRSRRPPKDPFNALLSYGYSLLYSNVLTAIYIAGLDPYIGFLHTDRSGRPSLVLDL 233
|
250 260
....*....|....*....|....*..
gi 2707155935 431 MEEFRPLIADSVAIGLINNGELRPSDF 457
Cdd:cd09636 234 MEEFRPQIVDRLVFSLINRGIITPEDF 260
|
|
| Cas1_I-B |
cd09722 |
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ... |
234-522 |
9.14e-41 |
|
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain
Pssm-ID: 187853 Cd Length: 320 Bit Score: 149.28 E-value: 9.14e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 234 FGNVQLTSQALRALAAREIPIvHL--SYGGWLSAITtppPHKHI---DLRRRQFATAVDQAVYVSLARAFVAGKIRN-TR 307
Cdd:cd09722 39 FGEVSLNSKALSFLSKKGIPI-HFfnYYGYYSGSFY---PRESLnsgYLIVKQVEHYLDSEKRLELARSFVEGAAHNmRR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 308 TLLRRNSRGlpAGVLERLAAARRRAERAKSLEQLLGIEGYAARDYFAHFACMFKPGedeqapaFEFTSRNRRPPRDPVNa 387
Cdd:cd09722 115 VLKYYKDRG--DDLDDYLDEIEEQKESANSINELMGVEGNIRKTYYSAFDEILKDE-------FRFEKRTRRPPKNELN- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 388 lllflyalltkemliTLVGVG----------------FDPYLGFYHQPKYGRPALALDLMEEFRPLIADSVAIGLINNGE 451
Cdd:cd09722 185 ---------------ALISFGnsllyttvlseiykthLNPTISYLHEPSERRFSLALDIAEIFKPIIVDRLIFRLVNKKI 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2707155935 452 LRPSDFIARAGAVALTDNGRRRVLDAYERRLDTLVTHPRFGYAISYRRIFEVQARLLARFLLGEiAEYPAF 522
Cdd:cd09722 250 IKEKHFEKDLNGVLLNEEGRKKFVKEFEEKLKTTIKHRKLKRKVSYRRLIRLELYKLIKHLLGE-EEYKPF 319
|
|
| Cas4 |
COG1468 |
CRISPR/Cas system-associated exonuclease Cas4, RecB family [Defense mechanisms]; CRISPR/Cas ... |
16-158 |
1.30e-32 |
|
CRISPR/Cas system-associated exonuclease Cas4, RecB family [Defense mechanisms]; CRISPR/Cas system-associated exonuclease Cas4, RecB family is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 441077 [Multi-domain] Cd Length: 184 Bit Score: 123.15 E-value: 1.30e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 16 EALDSMPELHARSVMAGSDTLGAVARIDVIEGEHEHVVPVDYKRGTPpdipeRAYEPERVQLCLQGLLLREQ-GYPCTHG 94
Cdd:COG1468 46 ERVYKRLERLRREVPLDSERLGLTGKIDLVEFEDGELVPVEYKKSKP-----KPWEADRMQLCAYALLLEEMlGIPVPKG 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2707155935 95 ILYFAASQTRVTVEFTEALQARTLELLAEARHTAAAGESPPPLVESPKCPRCSLVGICLPDEVN 158
Cdd:COG1468 121 YLYYPEERKREEVELTEELREEVEEAIEEIREILESEKPPPPTKSKKKCKKCSYREFCLPRETS 184
|
|
| cas4 |
TIGR00372 |
CRISPR-associated protein Cas4; This model represents a family of proteins associated with ... |
27-154 |
6.74e-18 |
|
CRISPR-associated protein Cas4; This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.
Pssm-ID: 273040 [Multi-domain] Cd Length: 178 Bit Score: 81.30 E-value: 6.74e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 27 RSVMAGSDTLGAVARIDVIEGEHEHVVPVDYKRGTPPdiPERAYepeRVQLCLQGLLLREQGYPCTHGILYFAASQTRVT 106
Cdd:TIGR00372 56 KEVPLKSKKYGLKGVIDIVLEEDGELVPVEVKSGKPS--PREAH---KYQLLAYAYLLEEMYGEIVRGYILYINAGKKLE 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2707155935 107 VEFTEALQARTLELLAEARHTAAAGESPPPLVESPKCPRCSLVGICLP 154
Cdd:TIGR00372 131 VEISEELRKKAVKLIEKIRELLEGGKPPSPPKSGPKCKFCPYREICLP 178
|
|
| Cas4_I-A_I-B_I-C_I-D_II-B |
cd09637 |
CRISPR/Cas system-associated protein Cas4; CRISPR (Clustered Regularly Interspaced Short ... |
27-153 |
3.41e-16 |
|
CRISPR/Cas system-associated protein Cas4; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster
Pssm-ID: 187768 [Multi-domain] Cd Length: 178 Bit Score: 76.70 E-value: 3.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 27 RSVMAGSDTLGAVARIDVIEGEHEHVVPVDYKRGtPPDIPERAYepeRVQLCLQGLLLREQ-GYPCTHGILYFAASQTRV 105
Cdd:cd09637 56 KEVPLKSKKYGLKGVIDIVLKEDGELVPVEVKSG-RAGSPREAH---KLQLVAYAYLLEEMyGKRVARGYIVYLEGGKRL 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2707155935 106 TVEFTEALQARTLELLAEARhTAAAGESPPPLVESPKCPRCSLVGICL 153
Cdd:cd09637 132 EVEISEELRKKAEKLLEEIR-KLLEGELPPPVKSSPKCKFCPYREICL 178
|
|
| Cas_Cas4 |
pfam01930 |
Domain of unknown function DUF83; This domain has no known function. The domain contains three ... |
41-154 |
2.62e-14 |
|
Domain of unknown function DUF83; This domain has no known function. The domain contains three conserved cysteines at its C terminus.
Pssm-ID: 426517 [Multi-domain] Cd Length: 160 Bit Score: 70.72 E-value: 2.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 41 RIDVIEGEHEHVVPVDYKRGTPPDiperayEPERVQLCLQGLLLREQGYPCThGILYFAASQTRVTVEFTEALQARTLEL 120
Cdd:pfam01930 55 KIDFVRRRGGGLVVHEVKKSSKME------EAHRMQLLYYLYYLKKRGIEIK-GVLHYPKERKREEVELTEEDRRELEEA 127
|
90 100 110
....*....|....*....|....*....|....
gi 2707155935 121 LAEARHtAAAGESPPPLVESPKCPRCSLVGICLP 154
Cdd:pfam01930 128 IKEIEE-IISSEKPPPPQKKKICKKCAYYEFCWP 160
|
|
| Cas1_II |
cd09720 |
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ... |
403-451 |
1.47e-05 |
|
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.
Pssm-ID: 187851 Cd Length: 275 Bit Score: 46.86 E-value: 1.47e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 2707155935 403 TLVGVGFDPYLGFYHQPKYGRPALALDLMEEFRPLIaDSVAIGLINNGE 451
Cdd:cd09720 189 ALVKAGLLPRLGIFHKSEYNPFNLADDLMEPFRPLV-DYLVYELLFESR 236
|
|
| cas1_NMENI |
TIGR03639 |
CRISPR-associated endonuclease Cas1, subtype II/NMENI; The CRISPR-associated protein Cas1 is ... |
403-451 |
3.84e-05 |
|
CRISPR-associated endonuclease Cas1, subtype II/NMENI; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.
Pssm-ID: 274694 Cd Length: 278 Bit Score: 45.71 E-value: 3.84e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 2707155935 403 TLVGVGFDPYLGFYHQPKYGRPALALDLMEEFRPLIaDSVAIGLINNGE 451
Cdd:TIGR03639 190 ALVKSGLLPRLGIFHKSEYNPFNLADDLMEPFRPLV-DYLVYELLIEEF 237
|
|
| PDDEXK_1 |
pfam12705 |
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ... |
39-152 |
7.01e-04 |
|
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily
Pssm-ID: 432731 [Multi-domain] Cd Length: 250 Bit Score: 41.37 E-value: 7.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2707155935 39 VARIDVIEGEHE-HVVPVDYKRGTPPDIPERAYEPERVQLCLQGLLLREQGYPCTH--GILYFAASQTRVTVEFTEALQA 115
Cdd:pfam12705 128 VGRIDRVDLDGEgYLRIIDYKTGSAPPQSEDLDLYEGLQLLLYLLALAAGEKALGGpaGALYLRLDDPLKKDEEVVEPMV 207
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2707155935 116 RTLE----LLAEARHTAAAGESPP-PLVESPKCPRCSLVGIC 152
Cdd:pfam12705 208 LTEDefdaLLQELRELAEEILAGEfPARPGKKCRYCPYRSIC 249
|
|
| |
