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Conserved domains on  [gi|2717453793|ref|WP_341533758|]
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TonB-dependent receptor domain-containing protein [Polymorphobacter fuscus]

Protein Classification

porin family protein( domain architecture ID 229388)

porin family protein is a member of a large superfamily consisting of classical (gram-negative ) porins which are non-specific channels for small hydrophillic molecules, maltoporin-like channels which have specificities for various sugars, and ligand-gated protein channels which cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OM_channels super family cl21487
Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in ...
 70-1008 3.60e-46

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20), which associate as trimers. Maltoporin-like channels have specificities for various sugars and form 18 beta-stranded barrels (18,22), which associate as trimers. Ligand-gated protein channels cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force and they form monomeric, (22,24) barrels. The 150-200 N-terminal residues form a plug that blocks the channel from the periplasmic end.


The actual alignment was detected with superfamily member cd01347:

Pssm-ID: 473880 [Multi-domain]  Cd Length: 635  Bit Score: 176.49  E-value: 3.60e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   70 PVIVTTAETIQLRASNVAEEVLRDIPGVvpsigSAVNNGNGGASYVDLRGIGSIRNIVLLDGNRIAPSGLAGRVDLNNIP 149
Cdd:cd01347      1 SVSVITAEDIEKQPATSLADLLRRIPGV-----SVTRGGGGGGSTISIRGFGPDRTLVLVDGLPLASSNYGRGVDLNTIP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  150 LALVERVDSLTGAAVTTYGADAISGVVNFVTKqdfsgidlqlgtslteqgdgqtvRADLTIGGNFDGGRGnavlsvgyqk 229
Cdd:cd01347     76 PELIERVEVLKGPSSALYGSGAIGGVVNIITK-----------------------RPTDEFGGSVTAGYG---------- 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  230 adpvyqgarefSANNVDSFTGAAGGSGTAIPSRFTGVRpidattglpsTNPAVANGNLQLDPTTGTARalfapfnfnpan 309
Cdd:cd01347    123 -----------SDNSGSSGGGGFDVSGALADDGAFGAR----------LYGAYRDGDGTIDGDGQADD------------ 169

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  310 ifqTPFERFNMYAQAKYDVSDHLEVYARGLFSKNTVNTVIAASGVFGSPVTINLNNPYLPAGLRnqfcaanvgsttayqa 389
Cdd:cd01347    170 ---SDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSSNTNGDR---------------- 230

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  390 rftpaqcaaaatatgptDPNYRTvetalarrttelgpriseYTTTIFDYRAGVRGaITDSIDYDLSGGYGESENRQalqg 469
Cdd:cd01347    231 -----------------DWDYRD------------------RYRKRASLGLEHDL-NDTGWTLRANLSYSYTDNDG---- 270

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  470 yvltskarntllannttncissdpgcvpvNWFGPAGSISPAQAAYLTAESSTVIKTSLAQARALISGDIGIALPSATdai 549
Cdd:cd01347    271 -----------------------------DPLILNGGNNAAGGDLGRSGYSSERDTTQLGFDAGLNAPFGTGPVAHT--- 318

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  550 gFAIGGEYRKYTASQradslaktpgelggaggaapdinggyDVKEVYGELiaplvqDKPFFENLTLEAGARYSDYKVDAP 629
Cdd:cd01347    319 -LTLGVEYRREELDE--------------------------KQTALYAQD------TIELTDDLTLTLGLRYDHYDQDSK 365

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  630 GNP--------SYDTFTWKAGGTWEMVQGFKVRGNYSRAVRAPNIGELFTPVTTGLTNlsvdpcaganpvtntalrtvcl 701
Cdd:cd01347    366 DTIaggttakkSYSHWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHGGTA---------------------- 423

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  702 aqgapatsiggiqqptagqanltTGGNLNLQPETANTWTVGAVFQPsfAPGLAITADYYNITVKDAVSSPlpgdivaacf 781
Cdd:cd01347    424 -----------------------AVGNPNLKPEKSKQYELGLKYDP--GDGLTLSAALFRIDIKNEIVST---------- 468

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  782 gappytspnansaacqaigrnpasggldgDPSTTRGLFAVQSNLGRIQTDGLDVTAFYSRDIGFaklGLTGNFNYTFSST 861
Cdd:cd01347    469 -----------------------------PTNTGLGLVTVYVNGGKARIRGVELEASYDLTDGL---GLTGSYTYTDTEV 516

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  862 FNADvTSPTGfarecvgyysvncsFTGSIQPKWQ--SSLRTTLGFNTFDVSLLWRHIDKVQQEPLDAVEQDplfgsfgRI 939
Cdd:cd01347    517 KRTD-GATTG--------------NRLPGIPKHTanLGLDYELPDEGLTAGGGVRYRGKQYADTANGNNTV-------KV 574

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2717453793  940 PSYNYFDLTGRFTIVENIALILTVTNLGDKKPPLVGSSAGSTSfnsgntypSTYDALGRRYAAQINVRF 1008
Cdd:cd01347    575 PGYTLVDLSASYQFTKNLTLRLGVNNLFDKDYYTSLSVRGSGL--------YGYYGPGRTYYLSVSYKF 635
 
Name Accession Description Interval E-value
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 70-1008 3.60e-46

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 176.49  E-value: 3.60e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   70 PVIVTTAETIQLRASNVAEEVLRDIPGVvpsigSAVNNGNGGASYVDLRGIGSIRNIVLLDGNRIAPSGLAGRVDLNNIP 149
Cdd:cd01347      1 SVSVITAEDIEKQPATSLADLLRRIPGV-----SVTRGGGGGGSTISIRGFGPDRTLVLVDGLPLASSNYGRGVDLNTIP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  150 LALVERVDSLTGAAVTTYGADAISGVVNFVTKqdfsgidlqlgtslteqgdgqtvRADLTIGGNFDGGRGnavlsvgyqk 229
Cdd:cd01347     76 PELIERVEVLKGPSSALYGSGAIGGVVNIITK-----------------------RPTDEFGGSVTAGYG---------- 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  230 adpvyqgarefSANNVDSFTGAAGGSGTAIPSRFTGVRpidattglpsTNPAVANGNLQLDPTTGTARalfapfnfnpan 309
Cdd:cd01347    123 -----------SDNSGSSGGGGFDVSGALADDGAFGAR----------LYGAYRDGDGTIDGDGQADD------------ 169

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  310 ifqTPFERFNMYAQAKYDVSDHLEVYARGLFSKNTVNTVIAASGVFGSPVTINLNNPYLPAGLRnqfcaanvgsttayqa 389
Cdd:cd01347    170 ---SDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSSNTNGDR---------------- 230

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  390 rftpaqcaaaatatgptDPNYRTvetalarrttelgpriseYTTTIFDYRAGVRGaITDSIDYDLSGGYGESENRQalqg 469
Cdd:cd01347    231 -----------------DWDYRD------------------RYRKRASLGLEHDL-NDTGWTLRANLSYSYTDNDG---- 270

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  470 yvltskarntllannttncissdpgcvpvNWFGPAGSISPAQAAYLTAESSTVIKTSLAQARALISGDIGIALPSATdai 549
Cdd:cd01347    271 -----------------------------DPLILNGGNNAAGGDLGRSGYSSERDTTQLGFDAGLNAPFGTGPVAHT--- 318

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  550 gFAIGGEYRKYTASQradslaktpgelggaggaapdinggyDVKEVYGELiaplvqDKPFFENLTLEAGARYSDYKVDAP 629
Cdd:cd01347    319 -LTLGVEYRREELDE--------------------------KQTALYAQD------TIELTDDLTLTLGLRYDHYDQDSK 365

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  630 GNP--------SYDTFTWKAGGTWEMVQGFKVRGNYSRAVRAPNIGELFTPVTTGLTNlsvdpcaganpvtntalrtvcl 701
Cdd:cd01347    366 DTIaggttakkSYSHWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHGGTA---------------------- 423

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  702 aqgapatsiggiqqptagqanltTGGNLNLQPETANTWTVGAVFQPsfAPGLAITADYYNITVKDAVSSPlpgdivaacf 781
Cdd:cd01347    424 -----------------------AVGNPNLKPEKSKQYELGLKYDP--GDGLTLSAALFRIDIKNEIVST---------- 468

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  782 gappytspnansaacqaigrnpasggldgDPSTTRGLFAVQSNLGRIQTDGLDVTAFYSRDIGFaklGLTGNFNYTFSST 861
Cdd:cd01347    469 -----------------------------PTNTGLGLVTVYVNGGKARIRGVELEASYDLTDGL---GLTGSYTYTDTEV 516

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  862 FNADvTSPTGfarecvgyysvncsFTGSIQPKWQ--SSLRTTLGFNTFDVSLLWRHIDKVQQEPLDAVEQDplfgsfgRI 939
Cdd:cd01347    517 KRTD-GATTG--------------NRLPGIPKHTanLGLDYELPDEGLTAGGGVRYRGKQYADTANGNNTV-------KV 574

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2717453793  940 PSYNYFDLTGRFTIVENIALILTVTNLGDKKPPLVGSSAGSTSfnsgntypSTYDALGRRYAAQINVRF 1008
Cdd:cd01347    575 PGYTLVDLSASYQFTKNLTLRLGVNNLFDKDYYTSLSVRGSGL--------YGYYGPGRTYYLSVSYKF 635
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 53-770 1.05e-32

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 135.37  E-value: 1.05e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGSLIRNPNLVSAAPVIVTTAETIQLRASNVAEEVLRDIPGVVpsigSAVNNGNGGASYVDLRGIGSIRNIVLLDGN 132
Cdd:COG4771     30 VVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALRLLPGVS----VTRSGGRGGSSGISIRGLGGDRVLVLIDGV 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  133 RIAPSGLAGRVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQDFSGIDLQLGTSLTEQGDGqTVRADLTIGG 212
Cdd:COG4771    106 PVNNPALGGGGDLSYIPPDDIERIEVIRGPASALYGSDAIGGVINIITKKPTDELEGSVSLGYGSNGNG-TYSGSLSLGG 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  213 NfdGGRGNAVLSVGYQKADPVYqgarefsannvdsftgaaggsgtaipsrftgvrpiDATTGLPSTNPAvangnlqldpt 292
Cdd:COG4771    185 P--GDKLSFLLSGSYRDRDGYL-----------------------------------DYRNGGFVGNSG----------- 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  293 tgtaralfapfnfnpanifqtpFERFNMYAQAKYDVSDHLEVYARGLFSKNTVNTVIAASGVFGSPVTINLNnpylpagl 372
Cdd:COG4771    217 ----------------------YERYNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPPTLGDTEISSDNAGD-------- 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  373 rnqfcaanvgsttayqarftpaqcaaaatatgptdpnyrtvetalarrttelgpriSEYTTTIFDYRAGVRGAITDSIdy 452
Cdd:COG4771    267 --------------------------------------------------------RDTTTDRGNYSLRYNGDLGDNL-- 288

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  453 DLSGGYGESENRqalqgyvltskarntllannttncissdpgcvpvnwfgpagSISPAQAAYLTAESSTVIKTSLAQARA 532
Cdd:COG4771    289 DLSLYYSRTDRD-----------------------------------------STNGSLGGSTGSFSDSDDTTYGLELDL 327

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  533 LIsgdigialpSATDAIGFAIGGEYRKYTASQRadslaktpgelggagGAAPDINGGYDVKEVYGELiaplvqDKPFFEN 612
Cdd:COG4771    328 TY---------PLGGNHTLTLGAEYRYDDLDSS---------------SFLGGADASRDTYGLFAQD------EWKLTDK 377

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  613 LTLEAGARYSDYKVDapGNPSYDTFTWKAGGTWEMVQGFKVRGNYSRAVRAPNIGELFTPVTTGLTNLSVdpcaganpvt 692
Cdd:COG4771    378 LTLTAGLRYDYYSTF--GASNYTAFSPRLGLRYDLSDNLTLRASYGRGFRAPSLAELYGSGTGTPGRYVL---------- 445

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2717453793  693 ntalrtvclaqgapatsiggiqqptagqanlttgGNLNLQPETANTWTVGAVFQPSFApGLAITADYYNITVKDAVSS 770
Cdd:COG4771    446 ----------------------------------GNPDLKPETSDNYELGLEYRLGNG-GLSLSLTGFYTDIKDLIVL 488
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 608-1007 1.61e-19

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 92.91  E-value: 1.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  608 PFFENLTLEAGARYSDYKVDAPGNP--------SYDTFTWKAGGTWEMVQGFKVRGNYSRAVRAPNIGELFTPVTTgltn 679
Cdd:pfam00593  184 KLTDRLTLTLGLRYDHYSTDGDDGNgggdnfsrSYSAFSPRLGLVYKPTDNLSLYASYSRGFRAPSLGELYGSGSG---- 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  680 lsvdpcaganpvtntalrtvclaqgapatsiggiqqptaGQANLTTGGNLNLQPETANTWTVGAVFQPSfapGLAITADY 759
Cdd:pfam00593  260 ---------------------------------------GGGGAVAGGNPDLKPETSDNYELGLKYDDG---RLSLSLAL 297

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  760 YNITVKDAVSSplpgdivaacfgappytspnansaacqaigrnpasgglDGDPSTTRGLFAVQSNLGRIQTDGLDVTAFY 839
Cdd:pfam00593  298 FYIDIKNLITS--------------------------------------DPDGPGLGGTVYTYTNVGKARIRGVELELSG 339

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  840 SrdigFAKLGLTGNfNYTFSSTFNADVTSPTGfarecvgyYSVNcsftgsIQPKWQSSLRTTLGF--NTFDVSLLWRHID 917
Cdd:pfam00593  340 R----LWGLGLSGG-GYTYTDADDDADADDTG--------NPLP------NVPRHTANLGLTYDFplGGWGARLGARYVG 400

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  918 KVQQEPLDAVEQDplfgsfgRIPSYNYFDLTGRFTIVENIALILTVTNLGDKKPplvgssagSTSFNSGNTYPSTYDALG 997
Cdd:pfam00593  401 SGERRYGDAANTF-------KTPGYTLVDLSAGYRLNKNLTLRLGVNNLFDKYY--------KRYYSSGGGNLGGYPGPG 465

                          410
                   ....*....|
gi 2717453793  998 RRYAAQINVR 1007
Cdd:pfam00593  466 RTFYLGLSYK 475
btuB PRK10641
TonB-dependent vitamin B12 receptor BtuB;
54-219 1.96e-18

TonB-dependent vitamin B12 receptor BtuB;


Pssm-ID: 236730 [Multi-domain]  Cd Length: 614  Bit Score: 90.44  E-value: 1.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   54 VVTGSLIRNPnlVSA--APVIVTTAETIQLRASNVAEEVLRDIPGVvpsiGSAVNNGNGGASYVDLRGIGSIRNIVLLDG 131
Cdd:PRK10641    29 VVTANRFQQP--VSTvlAPTTVVTRDDIDRWQSKSVNDVLRRLPGV----DIAQNGGLGQLSSLFIRGTNSSHVLVLIDG 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  132 NRIAPSGLAGRVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQDFSGIDLQ--LGTSLTEQGDGQTV----- 204
Cdd:PRK10641   103 VRLNQAGISGSADLSQIPISLVQRIEYIRGPRSAVYGSDAIGGVVNIITTRDKPGTTLSagWGSNGYQNYDGSTQqqlgd 182

                          170
                   ....*....|....*
gi 2717453793  205 RADLTIGGNFDGGRG 219
Cdd:PRK10641   183 NTRVTLAGDYTYTKG 197
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 71-239 6.69e-11

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 66.28  E-value: 6.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   71 VIVTTAETIQLRASNVAEEVLRDIPGVVpsigsaVNNGNGGASY--VDLRGIGSIRNI--VLLDGNRiapsgLAGRVDLN 146
Cdd:TIGR01783    6 VSVITRQELEDQQAGSLSEALQRVPGVV------VGGSGGTTQFgnITIRGFGLEVDIdnVYLDGVP-----LLSRGNLA 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  147 NIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQdfsGIDLQLGTSLTEQGDGQTVRADLTIGGNFDGGRGNAV-LSV 225
Cdd:TIGR01783   75 IVDPAMVERVEVLRGPASLLYGGSAPGGVINIVTKR---PQDEPKGSVTFGAGTRSGYRTAFDLGGPLGADGTFRGrLNG 151

                          170
                   ....*....|....
gi 2717453793  226 GYQKADPVYQGARE 239
Cdd:TIGR01783  152 ARQDGDSFYDGAGE 165
 
Name Accession Description Interval E-value
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 70-1008 3.60e-46

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 176.49  E-value: 3.60e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   70 PVIVTTAETIQLRASNVAEEVLRDIPGVvpsigSAVNNGNGGASYVDLRGIGSIRNIVLLDGNRIAPSGLAGRVDLNNIP 149
Cdd:cd01347      1 SVSVITAEDIEKQPATSLADLLRRIPGV-----SVTRGGGGGGSTISIRGFGPDRTLVLVDGLPLASSNYGRGVDLNTIP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  150 LALVERVDSLTGAAVTTYGADAISGVVNFVTKqdfsgidlqlgtslteqgdgqtvRADLTIGGNFDGGRGnavlsvgyqk 229
Cdd:cd01347     76 PELIERVEVLKGPSSALYGSGAIGGVVNIITK-----------------------RPTDEFGGSVTAGYG---------- 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  230 adpvyqgarefSANNVDSFTGAAGGSGTAIPSRFTGVRpidattglpsTNPAVANGNLQLDPTTGTARalfapfnfnpan 309
Cdd:cd01347    123 -----------SDNSGSSGGGGFDVSGALADDGAFGAR----------LYGAYRDGDGTIDGDGQADD------------ 169

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  310 ifqTPFERFNMYAQAKYDVSDHLEVYARGLFSKNTVNTVIAASGVFGSPVTINLNNPYLPAGLRnqfcaanvgsttayqa 389
Cdd:cd01347    170 ---SDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSSNTNGDR---------------- 230

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  390 rftpaqcaaaatatgptDPNYRTvetalarrttelgpriseYTTTIFDYRAGVRGaITDSIDYDLSGGYGESENRQalqg 469
Cdd:cd01347    231 -----------------DWDYRD------------------RYRKRASLGLEHDL-NDTGWTLRANLSYSYTDNDG---- 270

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  470 yvltskarntllannttncissdpgcvpvNWFGPAGSISPAQAAYLTAESSTVIKTSLAQARALISGDIGIALPSATdai 549
Cdd:cd01347    271 -----------------------------DPLILNGGNNAAGGDLGRSGYSSERDTTQLGFDAGLNAPFGTGPVAHT--- 318

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  550 gFAIGGEYRKYTASQradslaktpgelggaggaapdinggyDVKEVYGELiaplvqDKPFFENLTLEAGARYSDYKVDAP 629
Cdd:cd01347    319 -LTLGVEYRREELDE--------------------------KQTALYAQD------TIELTDDLTLTLGLRYDHYDQDSK 365

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  630 GNP--------SYDTFTWKAGGTWEMVQGFKVRGNYSRAVRAPNIGELFTPVTTGLTNlsvdpcaganpvtntalrtvcl 701
Cdd:cd01347    366 DTIaggttakkSYSHWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHGGTA---------------------- 423

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  702 aqgapatsiggiqqptagqanltTGGNLNLQPETANTWTVGAVFQPsfAPGLAITADYYNITVKDAVSSPlpgdivaacf 781
Cdd:cd01347    424 -----------------------AVGNPNLKPEKSKQYELGLKYDP--GDGLTLSAALFRIDIKNEIVST---------- 468

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  782 gappytspnansaacqaigrnpasggldgDPSTTRGLFAVQSNLGRIQTDGLDVTAFYSRDIGFaklGLTGNFNYTFSST 861
Cdd:cd01347    469 -----------------------------PTNTGLGLVTVYVNGGKARIRGVELEASYDLTDGL---GLTGSYTYTDTEV 516

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  862 FNADvTSPTGfarecvgyysvncsFTGSIQPKWQ--SSLRTTLGFNTFDVSLLWRHIDKVQQEPLDAVEQDplfgsfgRI 939
Cdd:cd01347    517 KRTD-GATTG--------------NRLPGIPKHTanLGLDYELPDEGLTAGGGVRYRGKQYADTANGNNTV-------KV 574

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2717453793  940 PSYNYFDLTGRFTIVENIALILTVTNLGDKKPPLVGSSAGSTSfnsgntypSTYDALGRRYAAQINVRF 1008
Cdd:cd01347    575 PGYTLVDLSASYQFTKNLTLRLGVNNLFDKDYYTSLSVRGSGL--------YGYYGPGRTYYLSVSYKF 635
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 53-770 1.05e-32

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 135.37  E-value: 1.05e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGSLIRNPNLVSAAPVIVTTAETIQLRASNVAEEVLRDIPGVVpsigSAVNNGNGGASYVDLRGIGSIRNIVLLDGN 132
Cdd:COG4771     30 VVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALRLLPGVS----VTRSGGRGGSSGISIRGLGGDRVLVLIDGV 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  133 RIAPSGLAGRVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQDFSGIDLQLGTSLTEQGDGqTVRADLTIGG 212
Cdd:COG4771    106 PVNNPALGGGGDLSYIPPDDIERIEVIRGPASALYGSDAIGGVINIITKKPTDELEGSVSLGYGSNGNG-TYSGSLSLGG 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  213 NfdGGRGNAVLSVGYQKADPVYqgarefsannvdsftgaaggsgtaipsrftgvrpiDATTGLPSTNPAvangnlqldpt 292
Cdd:COG4771    185 P--GDKLSFLLSGSYRDRDGYL-----------------------------------DYRNGGFVGNSG----------- 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  293 tgtaralfapfnfnpanifqtpFERFNMYAQAKYDVSDHLEVYARGLFSKNTVNTVIAASGVFGSPVTINLNnpylpagl 372
Cdd:COG4771    217 ----------------------YERYNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPPTLGDTEISSDNAGD-------- 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  373 rnqfcaanvgsttayqarftpaqcaaaatatgptdpnyrtvetalarrttelgpriSEYTTTIFDYRAGVRGAITDSIdy 452
Cdd:COG4771    267 --------------------------------------------------------RDTTTDRGNYSLRYNGDLGDNL-- 288

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  453 DLSGGYGESENRqalqgyvltskarntllannttncissdpgcvpvnwfgpagSISPAQAAYLTAESSTVIKTSLAQARA 532
Cdd:COG4771    289 DLSLYYSRTDRD-----------------------------------------STNGSLGGSTGSFSDSDDTTYGLELDL 327

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  533 LIsgdigialpSATDAIGFAIGGEYRKYTASQRadslaktpgelggagGAAPDINGGYDVKEVYGELiaplvqDKPFFEN 612
Cdd:COG4771    328 TY---------PLGGNHTLTLGAEYRYDDLDSS---------------SFLGGADASRDTYGLFAQD------EWKLTDK 377

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  613 LTLEAGARYSDYKVDapGNPSYDTFTWKAGGTWEMVQGFKVRGNYSRAVRAPNIGELFTPVTTGLTNLSVdpcaganpvt 692
Cdd:COG4771    378 LTLTAGLRYDYYSTF--GASNYTAFSPRLGLRYDLSDNLTLRASYGRGFRAPSLAELYGSGTGTPGRYVL---------- 445

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2717453793  693 ntalrtvclaqgapatsiggiqqptagqanlttgGNLNLQPETANTWTVGAVFQPSFApGLAITADYYNITVKDAVSS 770
Cdd:COG4771    446 ----------------------------------GNPDLKPETSDNYELGLEYRLGNG-GLSLSLTGFYTDIKDLIVL 488
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
53-290 2.60e-26

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 109.58  E-value: 2.60e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGSLIRNPNLVSAAPVIVTTAETIQLRASNVAEEVLRDIPGVVpsigSAVNNGNGGASYVDLRGIGSIRNIVLLDGN 132
Cdd:COG4206      1 VVVTATRLEQSKSDLTGSVTVIDAEELERSGATSLADALRRVPGVQ----VSSSGGPGSAASISIRGLGSNQTLVLIDGV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  133 RIApSGLAGRVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQDFSGIDLQLGTSLTEQGdgqTVRADLTIGG 212
Cdd:COG4206     77 PLN-DPSLGGVDLSLIPPDDIERIEVLKGAASALYGSDAIGGVINITTKKGKKGFKGSVSASYGSFG---TRRLSASLSG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  213 NfdGGRGNAVLSVGYQKADPV-YQGAREFSANNVDSFTGAAGGSGTAIPSRFTGV--RPIDATTGLPSTNPAVANGNLQL 289
Cdd:COG4206    153 G--AGKFSYSLSASYRRSDGYrYNDPDLRNNDGYENTSLNARLGYKLGDNGSLSLsgGYSDSERGYPGAVGSDRNLRLSL 230


                   .
gi 2717453793  290 D 290
Cdd:COG4206    231 S 231
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
53-970 4.61e-25

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 111.46  E-value: 4.61e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGSLIRNPNLVSAAPVIVTTAETIQLRASNVAEEVLRDIPGVVpsigsaVNNGNGGASYVDLRGIGSI--RNIVLLD 130
Cdd:COG1629      4 VVVTATRTDESLQDVPGSVSVISREQLEDQPATDLGDLLRRVPGVS------VTSAGGGAGQISIRGFGGGgnRVLVLVD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  131 GNRIaPSGLAGRVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQDFSGIDLQLGTSLteqGDGQTVRADLTI 210
Cdd:COG1629     78 GVPL-NDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTKKPKDGKGGEVSASY---GSYGTYRASLSL 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  211 GGNfdGGRGNAVLSVGYQKADpvyqGAREFSAnnvdsftgaaggsgtaipsrftgvrpidattglpstnpavangnlqld 290
Cdd:COG1629    154 SGG--NGKLAYRLSASYRDSD----GYRDNSD------------------------------------------------ 179

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  291 pttgtaralfapfnfnpanifqtpFERFNMYAQAKYDVSD--HLEVYARGLFSKNTVNTVIAASGVFGSPVTINLNNPYL 368
Cdd:COG1629    180 ------------------------SDRYNLRAKLGYQLGDdtRLTLSASYSDSDQDSPGYLTLAALRPRGAMDDGTNPYS 235

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  369 PAGLRNQFCAANVGsttayqarftpaqcaaaatatgptdpnyrtvetalarrttelgpriseytttiFDYRagvrgAITD 448
Cdd:COG1629    236 NDTDDNTRDRYSLS-----------------------------------------------------LEYE-----HLGD 257

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  449 SIDYDLSGGYGESENRQALQGYVLTSKARNTLLANNTTNCISSDpgcvpvnwfgpagsispaqaAYLTAESSTVIKTSLa 528
Cdd:COG1629    258 GLKLSASAYYRYDDTDLDSDFTPTPADGGTLEQTDFDNRTYGLE--------------------LRLTYDLGFGGKHTL- 316

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  529 qaralisgdigialpsatdaigfAIGGEYRKYTASQRADSLAKTPGELgGAGGAAPDINGGYDVKEVYGELiaplvqDKP 608
Cdd:COG1629    317 -----------------------LVGLDYQRQDLDGSGYPLDLGSGSL-PTLTSGADDDGTTTSLALYAQD------TYK 366

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  609 FFENLTLEAGARYSDYKVD----------APGNPSYDTFTWKAGGTWEMVQGFKVRGNYSRAVRAPNIGELFtpvttglt 678
Cdd:COG1629    367 LTDKLTLTAGLRYDYVSYDvddtvtgtdsASGSRSYSAFSPSLGLTYQLSPNLSLYASYSRGFRAPTFGELY-------- 438

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  679 nlsvdpcaganpvtntalrtvclaqgapatsiggiqqptAGQANLTTGGNLNLQPETANTWTVGAVFQPsFAPGLAITAD 758
Cdd:COG1629    439 ---------------------------------------ANGTDPYSVGNPDLKPETSTNYELGLRYRL-LDGRLSLSLA 478

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  759 YYNITVKDAVSSPLPGDivaacfgappytspnansaacqaigrnpasggldgdpstTRGLFAVQSNLGRIQTDGLDVTAF 838
Cdd:COG1629    479 LFYSDVDNEILSVPLPN---------------------------------------DSGFSTYYTNAGKARSYGVELELS 519

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  839 YSRDIGFaklglTGNFNYTFSstfNADVTSPTGFARECVGYYSVNcsftgsiQPKWQSSLRTTLGFNT-FDVSLLWRHID 917
Cdd:COG1629    520 YQLTPGL-----SLNASYSYT---DAKFDDDTDGSADLDGNRLPG-------VPPLTANLGLTYEFPGgWSLGLGVRYVG 584

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2717453793  918 KVQQEPLDaveqdplfgSFGRIPSYNYFDLTGRFTIVENIALILTVTNLGDKK 970
Cdd:COG1629    585 DRYLDDAN---------TQGAPGGYTLVDLGAGYRFGDNLTLSLGVDNLFDKK 628
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 608-1007 1.61e-19

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 92.91  E-value: 1.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  608 PFFENLTLEAGARYSDYKVDAPGNP--------SYDTFTWKAGGTWEMVQGFKVRGNYSRAVRAPNIGELFTPVTTgltn 679
Cdd:pfam00593  184 KLTDRLTLTLGLRYDHYSTDGDDGNgggdnfsrSYSAFSPRLGLVYKPTDNLSLYASYSRGFRAPSLGELYGSGSG---- 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  680 lsvdpcaganpvtntalrtvclaqgapatsiggiqqptaGQANLTTGGNLNLQPETANTWTVGAVFQPSfapGLAITADY 759
Cdd:pfam00593  260 ---------------------------------------GGGGAVAGGNPDLKPETSDNYELGLKYDDG---RLSLSLAL 297

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  760 YNITVKDAVSSplpgdivaacfgappytspnansaacqaigrnpasgglDGDPSTTRGLFAVQSNLGRIQTDGLDVTAFY 839
Cdd:pfam00593  298 FYIDIKNLITS--------------------------------------DPDGPGLGGTVYTYTNVGKARIRGVELELSG 339

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  840 SrdigFAKLGLTGNfNYTFSSTFNADVTSPTGfarecvgyYSVNcsftgsIQPKWQSSLRTTLGF--NTFDVSLLWRHID 917
Cdd:pfam00593  340 R----LWGLGLSGG-GYTYTDADDDADADDTG--------NPLP------NVPRHTANLGLTYDFplGGWGARLGARYVG 400

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  918 KVQQEPLDAVEQDplfgsfgRIPSYNYFDLTGRFTIVENIALILTVTNLGDKKPplvgssagSTSFNSGNTYPSTYDALG 997
Cdd:pfam00593  401 SGERRYGDAANTF-------KTPGYTLVDLSAGYRLNKNLTLRLGVNNLFDKYY--------KRYYSSGGGNLGGYPGPG 465

                          410
                   ....*....|
gi 2717453793  998 RRYAAQINVR 1007
Cdd:pfam00593  466 RTFYLGLSYK 475
btuB PRK10641
TonB-dependent vitamin B12 receptor BtuB;
54-219 1.96e-18

TonB-dependent vitamin B12 receptor BtuB;


Pssm-ID: 236730 [Multi-domain]  Cd Length: 614  Bit Score: 90.44  E-value: 1.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   54 VVTGSLIRNPnlVSA--APVIVTTAETIQLRASNVAEEVLRDIPGVvpsiGSAVNNGNGGASYVDLRGIGSIRNIVLLDG 131
Cdd:PRK10641    29 VVTANRFQQP--VSTvlAPTTVVTRDDIDRWQSKSVNDVLRRLPGV----DIAQNGGLGQLSSLFIRGTNSSHVLVLIDG 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  132 NRIAPSGLAGRVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQDFSGIDLQ--LGTSLTEQGDGQTV----- 204
Cdd:PRK10641   103 VRLNQAGISGSADLSQIPISLVQRIEYIRGPRSAVYGSDAIGGVVNIITTRDKPGTTLSagWGSNGYQNYDGSTQqqlgd 182

                          170
                   ....*....|....*
gi 2717453793  205 RADLTIGGNFDGGRG 219
Cdd:PRK10641   183 NTRVTLAGDYTYTKG 197
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 67-175 4.77e-18

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 80.39  E-value: 4.77e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   67 SAAPVIVTTAETIQLRASNVAEEVLRDIPGVvpsigSAVNNGNGGASYVDLRGIGSIRNIVLLDGNRIAPSGlAGRVDLN 146
Cdd:pfam07715    5 TPGSVSVVTAEDIEDQGATNLADALRGVPGV-----SVSSGGGGGGSSISIRGFGSNRVLVLVDGVPLNSGG-GGSVDLN 78

                           90       100
                   ....*....|....*....|....*....
gi 2717453793  147 NIPLALVERVDSLTGAAVTTYGADAISGV 175
Cdd:pfam07715   79 SIDPEDIERVEVLKGPASALYGSGAIGGV 107
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 53-217 2.99e-13

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 73.77  E-value: 2.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGSLIRNpNLVSA-APVIVTTAETIQLRASNVAEEVLRDIPGVvpSIGSAVNNGNGgasyVDLRGIGSIRNIVLLDG 131
Cdd:PRK10064    33 MVVTASAVEQ-NLKDApASISVITQEDLQRKPVQNLKDVLKEVPGV--QLTNEGDNRKG----VSIRGLDSSYTLILIDG 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  132 NRIAPSGLAGR---VDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTK---QDFSGiDLQLGTSLTEQGDgqtvR 205
Cdd:PRK10064   106 KRVNSRNAVFRhndFDLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKkigQKWHG-TVTVDTTIQEHRD----R 180

                          170
                   ....*....|..
gi 2717453793  206 ADLTIGGNFDGG 217
Cdd:PRK10064   181 GDTYNGQFFTSG 192
PRK13513 PRK13513
ligand-gated channel protein;
53-200 2.70e-11

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 67.49  E-value: 2.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGSLIRNPNLVSAAPVIVTTAETIQLRASNVAEEVLRDIPGVVPSigsavnnGNGGASYVDLRGIGSIRNIVLLDGN 132
Cdd:PRK13513    38 MVVTASGFQQRIQDAPASISVVTREQLENKAYRDVTDALKDVPGVVVT-------GGGSTSDISIRGMAAKYTLILVDGK 110

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2717453793  133 RIAPSGLAGRVDLNNI------PLALVERVDSLTGAAVTTYGADAISGVVNFVTK--QDFSGIDLQLGTSLTEQGD 200
Cdd:PRK13513   111 RVDTRSTRPNSDGSGIeqgwlpPLAAIERIEVVRGPMSSLYGSDAMGGVINIITRkvQKEWHGSLRADATLQEDSK 186
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
71-232 5.39e-11

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 66.44  E-value: 5.39e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   71 VIVTTAETIQLRASNVAEEVLRDIPGVvpsigSAVNNGNGGASYVDLRGIGSIRNIvLLDGNRIAPSglagrvdlNNIPL 150
Cdd:COG4774     13 VTVVTRELIEDQGATSLADALRNVPGV-----TFGAGEGGNGDSFSIRGFSASGDI-YVDGLRDPGQ--------YRRDT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  151 ALVERVDSLTGAAVTTYGADAISGVVNFVTKQ----DFSGIDLQLGTslteqGDGQTVRADLT--IGGNFdGGRGNAVls 224
Cdd:COG4774     79 FNLERVEVLKGPASVLYGRGSPGGVINLVTKRptdePFTEVTLTYGS-----DGQRRATLDVNgpLGDDL-AYRLNGM-- 150


                   ....*...
gi 2717453793  225 vgYQKADP 232
Cdd:COG4774    151 --YRDSDS 156
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 71-239 6.69e-11

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 66.28  E-value: 6.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   71 VIVTTAETIQLRASNVAEEVLRDIPGVVpsigsaVNNGNGGASY--VDLRGIGSIRNI--VLLDGNRiapsgLAGRVDLN 146
Cdd:TIGR01783    6 VSVITRQELEDQQAGSLSEALQRVPGVV------VGGSGGTTQFgnITIRGFGLEVDIdnVYLDGVP-----LLSRGNLA 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  147 NIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQdfsGIDLQLGTSLTEQGDGQTVRADLTIGGNFDGGRGNAV-LSV 225
Cdd:TIGR01783   75 IVDPAMVERVEVLRGPASLLYGGSAPGGVINIVTKR---PQDEPKGSVTFGAGTRSGYRTAFDLGGPLGADGTFRGrLNG 151

                          170
                   ....*....|....
gi 2717453793  226 GYQKADPVYQGARE 239
Cdd:TIGR01783  152 ARQDGDSFYDGAGE 165
PRK13483 PRK13483
ligand-gated channel protein;
53-247 1.35e-10

ligand-gated channel protein;


Pssm-ID: 184080 [Multi-domain]  Cd Length: 660  Bit Score: 65.18  E-value: 1.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGS----LIRNpnlvSAAPVIVTTAETIQLRASNVAEEVLRDIPGVVPSigsavnnGNGGASYVDLRGIGSIRNIVL 128
Cdd:PRK13483    36 VVVTASgyeqQIRD----APASISVITREDLENRFYRDLTDALLDVPGVVVT-------GGGDRTDISLRGMGSQYTLIL 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  129 LDGNRIA-----PSGLAGRVDLNNIP-LALVERVDSLTGAAVTTYGADAISGVVNFVTKQD---FSGiDLQLGTSLTEQG 199
Cdd:PRK13483   105 VDGKRQSsretrPNSDGPGVEQAWTPpLAAIERIEVIRGPMSSLYGSDAIGGVINIITRKVpneWQG-EVRLDTTLQENS 183

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2717453793  200 DGQTVRAdltigGNF--DGGRGNAVLSV----GYQK--ADPVYQGAREFSANNVDS 247
Cdd:PRK13483   184 DSGNVYQ-----ANFfvNGPLIKDLLGLqlygQYTQreEDDIEGGYRDKDARSLTA 234
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 18-346 1.41e-10

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 65.30  E-value: 1.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   18 ATLAIAMLAMPAAAyaqSTTGSTTTAAAAADEDAAIVVTGSLIRNPNLVSAAPVIVT----------------TAETIQL 81
Cdd:COG4773      3 ALLAGSGLAAAAAG---ALAQAAAAAAAEATTLPEVTVTGTAEGTGGYTAKSSSTATkldtplretpqsvsvvTRQLIED 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   82 RASNVAEEVLRDIPGVvpsigSAVNNGNGGASYVDLRGIGSirNIVLLDGNRIAPSGLAgrvdlnNIPLALVERVDSLTG 161
Cdd:COG4773     80 QGATTLDDALRNVPGV-----TVSSYDGGGRDSFSIRGFSI--DNYLRDGLPLGGFGGG------QPDTANLERVEVLKG 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  162 AAVTTYGADAISGVVNFVTKQ---DFSG-IDLQLGTslteqgdGQTVRADLTIGGNFD-----GGRGNAVlsvgYQKADP 232
Cdd:COG4773    147 PAGLLYGAGSPGGLVNLVTKRptaEPQGeVSLSAGS-------WDTYRATADVGGPLNedgtlRYRLNAA----YEDGDS 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  233 VYqgarefsaNNVDSFTGAAGGSGTAIPSrftgvrpiDATTglpstnpAVANGNLQLDPTTGTARALfaPFNFNPANI-- 310
Cdd:COG4773    216 FR--------DGVDNRRTLIAPSLDWDLT--------DDTT-------LTLGAEYQDDDSTGDRGFL--PLDGTLLDLpr 270

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 2717453793  311 ---FQTPFERFNM-----YAQAKYDVSDHLEVYARGLFSKNTVN 346
Cdd:COG4773    271 stnLGEPWDYYDTetttlFAELEHRFNDDWSLRANARYSDSDRD 314
PRK13486 PRK13486
TonB-dependent receptor;
53-183 3.61e-10

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 63.89  E-value: 3.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGSLIRNPNLVSAAPVIVTTAETIQLRASNVAEEVLRDIPGVVPSIGSavnnGNGGASYVDLRGIGSIRNIVLLDGN 132
Cdd:PRK13486    28 MIVSASGYEKKLTNAAASVSVISQEELQSSQYHDLAEALRSVEGVDVESGT----GKTGGLEISIRGMPASYTLILIDGV 103

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2717453793  133 R------IAPSGLAGRVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQD 183
Cdd:PRK13486   104 RqggssdVTPNGFSAMNTGFMPPLAAIERIEVIRGPMSTLYGSDAMGGVVNIITRKN 160
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
53-253 1.11e-09

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 62.25  E-value: 1.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGSLIRNPNL--VSAAPVIVTtAETIQLRASNVAEEVLRDIPGVVpsigSAVNNGNGGASYVDLRGIGS--IRNI-V 127
Cdd:COG4772     26 VVVTGSRAAEARLkdVPGSVSVVD-REELENQAATSLREVLRRVPGVN----VQEEDGFGLRPNIGIRGLGPrrSRGItL 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  128 LLDGNRIAPSGL-AGRVDLNNIPLAlVERVDSLTGAAVTTYGADAISGVVNFVTK---QDFSgidlqlGTSLTEQGDGQT 203
Cdd:COG4772    101 LEDGIPIAPAPYgDPAAYYFPDLER-MERIEVLRGAAALRYGPQTVGGAINFVTRtipTAFG------GELRVTGGSFGY 173

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2717453793  204 VRADLTIGGNFdgGRGNAVLSVGYQKADpvyqGAREFSANNVDSFTGAAG 253
Cdd:COG4772    174 RRTHASVGGTV--GNFGYLVEYSRKRGD----GFRDNSGFDINDFNAKLG 217
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
609-1008 1.37e-09

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 62.25  E-value: 1.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  609 FFENLTLEAGARYSD--------YKVDAPGNPS----YDTFTWKAGGTWEMVQGFKVRGNYSRAVRAPNIGELFTPvttg 676
Cdd:COG4772    391 LTGRLTLTPGLRYEHirrdrtdrYSTRTGGDDSgsnsYSEFLPGLGLLYQLTDNLQLYANVSRGFEPPTFGDLAYG---- 466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  677 ltnlsvdpcaganpvtntalrtvclaqgapatsiggiqqptagqanltTGGNLNLQPETANTWTVGAVFQPSfaPGLAIT 756
Cdd:COG4772    467 ------------------------------------------------NGGNPDLKPEKSWNYELGTRGRIG--NGLSAE 496

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  757 ADYYNITVKDavssplpgdivaacfgappytspnansaacqAIGRNPASGGLDgdpsttrglfAVQSNLGRIQTDGLDVT 836
Cdd:COG4772    497 VALFYIDYDN-------------------------------ELGSCSAAGGDR----------STFTNAGETRHQGLELA 535

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  837 AFYsrDIGFAKL-GLTGNFNYTFS-STFNADVTSPTGFARecVGYYsvncsftgsiqPKWQSSLRTTLGFNTFDVSLLWR 914
Cdd:COG4772    536 LDY--DLLKGGGlGLPLFAAYTYTdAEFTSDFGPVFAGNR--LPYV-----------PRHQLTAGLGYEHGGWTANLNGR 600

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  915 HIDKVQQEPLDAVEQdplfGSFGRIPSYNYFDLTGRFTIVENIALILTVTNLGDKKpplvgsSAGSTSFNSGNTYpstYD 994
Cdd:COG4772    601 YVSEQFTDAANTVAD----GSFGKIPSYTVLDLSASYDFGKNLSLFAGVNNLFDKR------YIASRAPNYAAGI---RP 667

                          410
                   ....*....|....
gi 2717453793  995 ALGRRYAAQINVRF 1008
Cdd:COG4772    668 GPPRTVYAGLRLKF 681
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
53-236 3.79e-09

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 60.79  E-value: 3.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   53 IVVTGSLIRNPNLVSAAPVIVTTAETIQLRASNVAEEVLRDIPGVvpSIgsavnNGNGGASYVDLRGIGSIRNIVLLDGN 132
Cdd:PRK13484    33 LVVTASGFTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKDVEGI--SI-----TGGNEKPDISIRGLSGDYTLILVDGR 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793  133 RIA-----PSGLAGRVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTK----QDFSGIdLQLGTSLTEQGD-GQ 202
Cdd:PRK13484   106 RQSgresrPNGSGGFEAGFIPPVEAIERIEVIRGPMSSLYGSDAIGGVINIITKpvnnQTWDGV-LGLGGIIQEHGKfGN 184

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2717453793  203 TVRADLTIGGNFDGGRGNAVL--SVGYQKADPVYQG 236
Cdd:PRK13484   185 STTNDFYLSGPLIKDKLGLQLygGMNYRKEDSISQG 220
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 71-212 5.62e-09

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 60.16  E-value: 5.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   71 VIVTTAETIQLRA-SNVAEEVLRDIPGVVPSiGSAVNNGNGGASYVDLRGIGSIRNIVLLDGNRIAPS-----GLAG--- 141
Cdd:PRK13528    53 VSIITAEDIKKRPpVNDLSDIIRKMPGVNLT-GNSASGTRGNNRQIDIRGMGPENTLILIDGVPVTSRnsvrySWRGerd 131

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2717453793  142 -RVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQ---DFSGiDLQLGTSLTEQGD-GQTVRADLTIGG 212
Cdd:PRK13528   132 tRGDTNWVPPEMVERIEVIRGPAAARYGSGAAGGVVNIITKRptnDWHG-SLSLYTNQPESSKeGATRRANFSLSG 206
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
68-182 5.51e-08

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 56.96  E-value: 5.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2717453793   68 AAPVIVTTAETIQLRA-SNVAEEVLRDIPGVVPSiGSAVNNGNGGASYVDLRGIGSIRNIVLLDGNRIAPS-----GLAG 141
Cdd:PRK13524    52 APGVSTITAEDIRKRPpANDVSEIIRTMPGVNLT-GNSTSGQRGNNRQIDIRGMGPENTLILIDGKPVSSRnsvryGWRG 130

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2717453793  142 ----RVDLNNIPLALVERVDSLTGAAVTTYGADAISGVVNFVTKQ 182
Cdd:PRK13524   131 erdtRGDTNWVPPEMIERIEVLRGPAAARYGNGAAGGVVNIITKK 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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