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Conserved domains on  [gi|2721292501|ref|WP_342106547|]
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helix-turn-helix transcriptional regulator [Serratia nevei]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 12204063)

helix-turn-helix (HTH) transcriptional regulator containing an AraC family DNA-binding HTH domain controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.1310
Gene Ontology:  GO:0006355|GO:0043565|GO:0003700
PubMed:  2644244|15808743|8831795
SCOP:  4000332

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
58-141 2.20e-26

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 95.70  E-value: 2.20e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501   58 KLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAFRHHFGLSP 137
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 2721292501  138 KEMR 141
Cdd:smart00342  81 SEYR 84
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
58-141 2.20e-26

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 95.70  E-value: 2.20e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501   58 KLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAFRHHFGLSP 137
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 2721292501  138 KEMR 141
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
55-141 1.54e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 93.31  E-value: 1.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  55 LDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAFRHHFG 134
Cdd:COG2207   165 LLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFG 244


                  ....*..
gi 2721292501 135 LSPKEMR 141
Cdd:COG2207   245 VTPSEYR 251
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
48-156 6.28e-23

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 88.24  E-value: 6.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  48 FSWIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFAR 127
Cdd:PRK11511   15 LDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTR 94

                          90       100
                  ....*....|....*....|....*....
gi 2721292501 128 AFRHHFGLSPKEMRGAKIIPEGKRVYPLD 156
Cdd:PRK11511   95 TFKNYFDVPPHKYRMTNMQGESRFLHPLN 123
MarA_TF NF012198
MDR efflux pump AcrAB transcriptional activator MarA;
48-156 2.35e-21

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 411088  Cd Length: 124  Bit Score: 84.03  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  48 FSWIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFAR 127
Cdd:NF012198   15 LDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTR 94

                          90       100
                  ....*....|....*....|....*....
gi 2721292501 128 AFRHHFGLSPKEMRGAKIIPEGKRVYPLD 156
Cdd:NF012198   95 TFKNYFDVPPHKYRITNMPGESRYLHPLN 123
HTH_18 pfam12833
Helix-turn-helix domain;
64-141 2.58e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.94  E-value: 2.58e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2721292501  64 ISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDA-ELSITDIFCMVGFYENSTFARAFRHHFGLSPKEMR 141
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
RobA_TF NF012228
MDR efflux pump AcrAB transcriptional activator RobA; The original characterization of RobA as ...
 49-137 1.46e-17

MDR efflux pump AcrAB transcriptional activator RobA; The original characterization of RobA as a Right side Origin of replication Binding protein A (robA) may be misleading. Characterizations in large numbers of papers since then treat RobA as a transcriptional activator of the AcrAB antibiotic efflux pump.


Pssm-ID: 467958 [Multi-domain]  Cd Length: 286  Bit Score: 77.64  E-value: 1.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  49 SWIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARA 128
Cdd:NF012228   10 VWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGQAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRA 89


                  ....*....
gi 2721292501 129 FRHHFGLSP 137
Cdd:NF012228   90 FKKQFNQTP 98
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 50-141 1.37e-10

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 58.53  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  50 WIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMtIAANLIIDAELSITDIFCMVGFYENSTFARAF 129
Cdd:TIGR04094 293 YINLNLYDPLKVEEIAKQFFMSESKLRKLFKKEMGISIQEYISKRKI-EEAKYLLRSQIPVSEVSNELGFYDLSHFSRTF 371

                          90
                  ....*....|..
gi 2721292501 130 RHHFGLSPKEMR 141
Cdd:TIGR04094 372 KKHTGVSPKQYQ 383
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
58-141 2.20e-26

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 95.70  E-value: 2.20e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501   58 KLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAFRHHFGLSP 137
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 2721292501  138 KEMR 141
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
55-141 1.54e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 93.31  E-value: 1.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  55 LDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAFRHHFG 134
Cdd:COG2207   165 LLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFG 244


                  ....*..
gi 2721292501 135 LSPKEMR 141
Cdd:COG2207   245 VTPSEYR 251
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
48-156 6.28e-23

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 88.24  E-value: 6.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  48 FSWIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFAR 127
Cdd:PRK11511   15 LDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTR 94

                          90       100
                  ....*....|....*....|....*....
gi 2721292501 128 AFRHHFGLSPKEMRGAKIIPEGKRVYPLD 156
Cdd:PRK11511   95 TFKNYFDVPPHKYRMTNMQGESRFLHPLN 123
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
50-141 6.55e-22

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 84.98  E-value: 6.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  50 WIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAF 129
Cdd:PRK10219   13 WIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVF 92

                          90
                  ....*....|..
gi 2721292501 130 RHHFGLSPKEMR 141
Cdd:PRK10219   93 RRQFDRTPSDYR 104
MarA_TF NF012198
MDR efflux pump AcrAB transcriptional activator MarA;
48-156 2.35e-21

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 411088  Cd Length: 124  Bit Score: 84.03  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  48 FSWIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFAR 127
Cdd:NF012198   15 LDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTR 94

                          90       100
                  ....*....|....*....|....*....
gi 2721292501 128 AFRHHFGLSPKEMRGAKIIPEGKRVYPLD 156
Cdd:NF012198   95 TFKNYFDVPPHKYRITNMPGESRYLHPLN 123
HTH_18 pfam12833
Helix-turn-helix domain;
64-141 2.58e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.94  E-value: 2.58e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2721292501  64 ISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDA-ELSITDIFCMVGFYENSTFARAFRHHFGLSPKEMR 141
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 50-157 2.25e-19

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 83.18  E-value: 2.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  50 WIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLiIDAELSITDIFCMVGFYENSTFARAF 129
Cdd:COG2169    92 LIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQL-LQTGLSVTDAAYAAGFGSLSRFYEAF 170

                          90       100
                  ....*....|....*....|....*...
gi 2721292501 130 RHHFGLSPKEMRGAKIIPEGKRVYPLDW 157
Cdd:COG2169   171 KKLLGMTPSAYRRGGAGAAIRFAPTPCS 198
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 50-141 9.33e-19

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 81.36  E-value: 9.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  50 WIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAF 129
Cdd:COG4977   218 WMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAF 297

                          90
                  ....*....|..
gi 2721292501 130 RHHFGLSPKEMR 141
Cdd:COG4977   298 RRRFGVSPSAYR 309
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
49-137 5.38e-18

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 78.90  E-value: 5.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  49 SWIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARA 128
Cdd:PRK15121   12 IWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRA 91


                  ....*....
gi 2721292501 129 FRHHFGLSP 137
Cdd:PRK15121   92 FKKQFAQTP 100
RobA_TF NF012228
MDR efflux pump AcrAB transcriptional activator RobA; The original characterization of RobA as ...
 49-137 1.46e-17

MDR efflux pump AcrAB transcriptional activator RobA; The original characterization of RobA as a Right side Origin of replication Binding protein A (robA) may be misleading. Characterizations in large numbers of papers since then treat RobA as a transcriptional activator of the AcrAB antibiotic efflux pump.


Pssm-ID: 467958 [Multi-domain]  Cd Length: 286  Bit Score: 77.64  E-value: 1.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  49 SWIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARA 128
Cdd:NF012228   10 VWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGQAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRA 89


                  ....*....
gi 2721292501 129 FRHHFGLSP 137
Cdd:NF012228   90 FKKQFNQTP 98
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 50-141 1.37e-10

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 58.53  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  50 WIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMtIAANLIIDAELSITDIFCMVGFYENSTFARAF 129
Cdd:TIGR04094 293 YINLNLYDPLKVEEIAKQFFMSESKLRKLFKKEMGISIQEYISKRKI-EEAKYLLRSQIPVSEVSNELGFYDLSHFSRTF 371

                          90
                  ....*....|..
gi 2721292501 130 RHHFGLSPKEMR 141
Cdd:TIGR04094 372 KKHTGVSPKQYQ 383
ftrA PRK09393
transcriptional activator FtrA; Provisional
 48-141 1.71e-09

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 55.36  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  48 FSWIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFAR 127
Cdd:PRK09393  224 IDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRH 303

                          90
                  ....*....|....
gi 2721292501 128 AFRHHFGLSPKEMR 141
Cdd:PRK09393  304 HFRRRAATSPAAYR 317
PRK10371 PRK10371
transcriptional regulator MelR;
43-141 2.40e-06

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 46.35  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  43 FASVFFSWIEDNLDRKLTMDEISEFTG----YSKWHFQRgfrdFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVG 118
Cdd:PRK10371  192 YVSQMLGFIAENYDQALTINDVAEHVKlnanYAMGIFQR----VMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAG 267

                          90       100
                  ....*....|....*....|...
gi 2721292501 119 FYENSTFARAFRHHFGLSPKEMR 141
Cdd:PRK10371  268 FRSSSRFYSTFGKYVGMSPQQYR 290
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 51-92 3.23e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 42.14  E-value: 3.23e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2721292501  51 IEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIR 92
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 51-141 7.54e-06

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 44.64  E-value: 7.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  51 IEDNLDRK-LTMDEISEFTGYSKWHFQRGFRDFfGMTLMAYIRGRKMTIAA---NLIIDAElSITDIFCMVGFYENSTFA 126
Cdd:PRK09685  206 IDQSIQEEiLRPEWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCAddlRPAADDE-KITSIAYKWGFSDSSHFS 283

                          90
                  ....*....|....*
gi 2721292501 127 RAFRHHFGLSPKEMR 141
Cdd:PRK09685  284 TAFKQRFGVSPGEYR 298
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
50-141 7.60e-05

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 41.59  E-value: 7.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  50 WIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAF 129
Cdd:PRK13503  179 WLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLF 258

                          90
                  ....*....|..
gi 2721292501 130 RHHFGLSPKEMR 141
Cdd:PRK13503  259 RREFSWSPRDIR 270
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
51-141 1.68e-04

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 40.73  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  51 IEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAFR 130
Cdd:PRK10572  192 ISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFK 271

                          90
                  ....*....|.
gi 2721292501 131 HHFGLSPKEMR 141
Cdd:PRK10572  272 KCTGASPSEFR 282
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
54-141 1.89e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 40.86  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  54 NLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAFRHHF 133
Cdd:PRK13500  218 SLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRET 297


                  ....*...
gi 2721292501 134 GLSPKEMR 141
Cdd:PRK13500  298 GMTPSQWR 305
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
51-141 5.25e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 39.27  E-value: 5.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  51 IEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAFR 130
Cdd:PRK13502  185 LANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFT 264

                          90
                  ....*....|.
gi 2721292501 131 HHFGLSPKEMR 141
Cdd:PRK13502  265 RETGMTPSQWR 275
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
56-141 1.20e-03

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 38.24  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  56 DRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAY---IRGRKMTIAanliIDAELSITDIFCMVGFYENSTFARAFRHH 132
Cdd:PRK15435   97 ETPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWqqaWRARRLREA----LAKGESVTTSILNAGFPDSSSYYRKADET 172


                  ....*....
gi 2721292501 133 FGLSPKEMR 141
Cdd:PRK15435  173 LGMTAKQFR 181
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 44-139 2.76e-03

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 37.35  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721292501  44 ASVFFSWIEDNLDRKLTMDEISEFTGYSKWHFQRGFRDFFGMTLMAYIRGRkMTIAANLIIDAELSITDIFCMVGFYENS 123
Cdd:PRK15186  183 AENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNAR-MNKATKLLRNSEYNITRVAYMCGYDSAS 261

                          90
                  ....*....|....*.
gi 2721292501 124 TFARAFRHHFGLSPKE 139
Cdd:PRK15186  262 YFTCVFKKHFKTTPSE 277
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
79-141 5.01e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 36.42  E-value: 5.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2721292501  79 FRDFFGMTLMAYIRGRKMTIAANLIIDAELSITDIFCMVGFYENSTFARAFRHHFGLSPKEMR 141
Cdd:PRK13501  213 FRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYR 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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