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Conserved domains on  [gi|2731057570|ref|WP_345167484|]
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NAD(P)H-hydrate dehydratase [Algibacter aquimarinus]

Protein Classification

NAD(P)H-hydrate epimerase( domain architecture ID 10000547)

NAD(P)H-hydrate epimerase catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 1-501 3.24e-121

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


:

Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 364.96  E-value: 3.24e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570   1 MKIFSKEQIYAGDKLTAEKQQISSTDLMERAGTQIFNWMHMRMQGAQVPIHVFCGIGNNGGDGLVLARHLITHGYNVNTF 80
Cdd:COG0062     1 MKLLTAAQMRALDRAAIEALGIPGLVLMERAGRAVARAIRRRFPSAARRVLVLCGPGNNGGDGLVAARLLAEAGYNVTVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  81 IINCSDKRSKDFLINYDRIKNVTKKWpvlLSCAEDFPEINPDDIIVDAVFGIGLNRPVDEWVKNLFKHFRASKAFTLAID 160
Cdd:COG0062    81 LLGDPEKLSGDAAANLERLKAAGIPI---LELDDELPELAEADLIVDALFGTGLSRPLRGPYAELIEAINASGAPVLAVD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 161 IPSGLFPDKAiEDEDAVVWAGFTLSFASPKLVFFLPETAKYTVQWEVLDIGLDQEFLFTTETEVELIGKHEVLPnYIPRE 240
Cdd:COG0062   158 IPSGLDADTG-EVLGAAVRADLTVTFGAPKPGLLLGPGRDYCGELVVADIGIGIPAAAEAPAALLLLADLLALL-LPPRR 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 241 KFSHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITDTNEEKITSISFDIEPTV 320
Cdd:COG0062   236 RSHHKGGGGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAALLAALPEAMALALDDDEELLLLLAAAVVVA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 321 IGLGIGVGTDTDTIKAFEAFLKTNKAPLVIDADGINILSKKKTLLKLLPEATVLTPHPKELERLIGTWKDDFDKLKKVKT 400
Cdd:COG0062   316 GGGGGGGGGAGGGLLLLLLLLLLLLVLLAAALLLLLALAAALLLLLLLPPPLAAALLLLRLLTELLELRAAAAALLAAAA 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 401 FSKKHKLIIIIKGANTITVFEDKLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFGVYLHGKSADIAIEDFG 480
Cdd:COG0062   396 AAAAVAAAAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGLLAGAAAAAAAAAAAAAAAAAAAAAAAALA 475

                         490       500
                  ....*....|....*....|.
gi 2731057570 481 YQSLIASHVIDYLGEAYLDLF 501
Cdd:COG0062   476 AALLAAAAALIALLLAAALLL 496
 
Name Accession Description Interval E-value
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 1-501 3.24e-121

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 364.96  E-value: 3.24e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570   1 MKIFSKEQIYAGDKLTAEKQQISSTDLMERAGTQIFNWMHMRMQGAQVPIHVFCGIGNNGGDGLVLARHLITHGYNVNTF 80
Cdd:COG0062     1 MKLLTAAQMRALDRAAIEALGIPGLVLMERAGRAVARAIRRRFPSAARRVLVLCGPGNNGGDGLVAARLLAEAGYNVTVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  81 IINCSDKRSKDFLINYDRIKNVTKKWpvlLSCAEDFPEINPDDIIVDAVFGIGLNRPVDEWVKNLFKHFRASKAFTLAID 160
Cdd:COG0062    81 LLGDPEKLSGDAAANLERLKAAGIPI---LELDDELPELAEADLIVDALFGTGLSRPLRGPYAELIEAINASGAPVLAVD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 161 IPSGLFPDKAiEDEDAVVWAGFTLSFASPKLVFFLPETAKYTVQWEVLDIGLDQEFLFTTETEVELIGKHEVLPnYIPRE 240
Cdd:COG0062   158 IPSGLDADTG-EVLGAAVRADLTVTFGAPKPGLLLGPGRDYCGELVVADIGIGIPAAAEAPAALLLLADLLALL-LPPRR 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 241 KFSHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITDTNEEKITSISFDIEPTV 320
Cdd:COG0062   236 RSHHKGGGGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAALLAALPEAMALALDDDEELLLLLAAAVVVA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 321 IGLGIGVGTDTDTIKAFEAFLKTNKAPLVIDADGINILSKKKTLLKLLPEATVLTPHPKELERLIGTWKDDFDKLKKVKT 400
Cdd:COG0062   316 GGGGGGGGGAGGGLLLLLLLLLLLLVLLAAALLLLLALAAALLLLLLLPPPLAAALLLLRLLTELLELRAAAAALLAAAA 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 401 FSKKHKLIIIIKGANTITVFEDKLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFGVYLHGKSADIAIEDFG 480
Cdd:COG0062   396 AAAAVAAAAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGLLAGAAAAAAAAAAAAAAAAAAAAAAAALA 475

                         490       500
                  ....*....|....*....|.
gi 2731057570 481 YQSLIASHVIDYLGEAYLDLF 501
Cdd:COG0062   476 AALLAAAAALIALLLAAALLL 496
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 243-493 3.11e-71

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 227.50  E-value: 3.11e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 243 SHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITDTNEEKITSISFDIEPTVIG 322
Cdd:cd01171     3 SHKGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATPPEAAAVIKSYSPELMVHPLLETDIEELLELLERADAVV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 323 LGIGVGTDTDTIKAFEAFLKTNKaPLVIDADGINIlSKKKTLLKLLPEATVLTPHPKELERLIG--TWKDDFDKLKKVKT 400
Cdd:cd01171    83 IGPGLGRDEEAAEILEKALAKDK-PLVLDADALNL-LADEPSLIKRYGPVVLTPHPGEFARLLGalVEEIQADRLAAARE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 401 FSKKHKLIIIIKGANTITVFED-KLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFGVYLHGKSADIAIEDF 479
Cdd:cd01171   161 AAAKLGATVVLKGAVTVIADPDgRVYVNPTGNPGLATGGSGDVLAGIIAALLAQGLSPLEAAALAVYLHGLAGDLAAKKK 240

                         250
                  ....*....|....
gi 2731057570 480 GYQSLIASHVIDYL 493
Cdd:cd01171   241 GAGLTAADLVAEIP 254
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 3-493 6.01e-52

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 184.49  E-value: 6.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570   3 IFSKEQIYAGDKLTAEKQQISSTDLMERAGTQIFNWMHMRMQGAQvpiH--VFCGIGNNGGDGLVLARHLITHGYNVnTF 80
Cdd:PRK10565   17 VWPADDIRRGEREAADALGLTLYELMLRAGEAAFQVARSAYPDAR---HwlVLCGHGNNGGDGYVVARLAQAAGIDV-TL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  81 IINCSDK---------RSKdFLINYDRIKNVTKKWPvllscaedfpeiNPDDIIVDAVFGIGLNRPVDEWVKNLFKHFRA 151
Cdd:PRK10565   93 LAQESDKplpeeaalaREA-WLNAGGEIHAADIVWP------------ESVDLIVDALLGTGLRQAPREPYAALIDQANA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 152 SKAFTLAIDIPSGLFPDKAIEdEDAVVWAGFTLSFASPKLVFFLPETAKYTVQWEVLDIGLdQEFLFTTETEVELIGKHE 231
Cdd:PRK10565  160 HPAPVVALDIPSGLLAETGAT-PGAVINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGL-DSWLAGQEAPIQRFDAEQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 232 vLPNYI-PREKFSHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITDTNEEKIT 310
Cdd:PRK10565  238 -LSQWLkPRRPTSHKGDHGRLLIIGGDHGTAGAIRMAGEAALRSGAGLVRVLTRSENIAPLLTARPELMVHELTPDSLEE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 311 SISFdiePTVIGLGIGVGTDTDTIKAFEAFLKTNKaPLVIDADGINIlskkktlLKLLPEAT---VLTPHPKELERLIGT 387
Cdd:PRK10565  317 SLEW---ADVVVIGPGLGQQEWGKKALQKVENFRK-PMLWDADALNL-------LAINPDKRhnrVITPHPGEAARLLGC 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 388 WKDDF--DKLKKVKTFSKKHKLIIIIKGANTITVFE-DKLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFG 464
Cdd:PRK10565  386 SVAEIesDRLLSARRLVKRYGGVVVLKGAGTVIAAEpDALAIIDVGNAGMASGGMGDVLSGIIGALLGQKLSPYDAACAG 465

                         490       500
                  ....*....|....*....|....*....
gi 2731057570 465 VYLHGKSADIAIEDFGYQSLIASHVIDYL 493
Cdd:PRK10565  466 CVAHGAAADVLAARFGTRGMLATDLFSTL 494
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 238-496 8.43e-51

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 174.49  E-value: 8.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 238 PREKFSHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMV-----ITDTNEEKITSI 312
Cdd:TIGR00196  14 LRDPNSHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVAAPENVITLINSVSPELIVhrlmwKVDEDEELLERY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 313 SfdieptVIGLGIGVGTDTDTIKAFEAFLKTNKaPLVIDADGINILSKKKTLLkllpEATVLTPHPKELERLIGTWKDDF 392
Cdd:TIGR00196  94 D------VVVIGPGLGQDPSFKKAVEEVLELDK-PVVLDADALNLLTYNQKRE----GEVILTPHPGEFKRLLGVNEIQG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 393 DKLKKVKTFSKKHKLIIIIKGA-NTITVFEDKLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFGVYLHGKS 471
Cdd:TIGR00196 163 DRLEAAQDIAQKLQAVVVLKGAaDVIAAPDGDLWINKTGNAALAKGGTGDVLAGLIGGLLAQNLDPFDAACNAAFAHGLA 242

                         250       260
                  ....*....|....*....|....*
gi 2731057570 472 ADIAIEDFGYQSLIASHVIDYLGEA 496
Cdd:TIGR00196 243 GDLALKNHGAYGLTALDLIEKIPRV 267
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 252-493 1.65e-40

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 146.35  E-value: 1.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 252 LIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITDTNEEKITSISFDIEptVIGLGIGVGTDT 331
Cdd:pfam01256   2 LVIGGSKDYTGAPLLAALAALRSGAGLVSVATDSEAIAVLKSPLPEVMVHPLPETSSILEKLSRYD--AVVIGPGLGRDE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 332 DTIKAFEAFLKTNKaPLVIDADGINILSKKKTLLKLLpEATVLTPHPKELERL---IGTWKDDfdKLKKVKTFSKKHKLI 408
Cdd:pfam01256  80 KGKAALEEVLAKDC-PLVIDADALNLLAINNEKPARE-GPTVLTPHPGEFERLcglAGILGDD--RLEAARELAQKLNGT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 409 IIIKGANTITVFEDK-LYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFGVYLHGKSADIAIEDFGYqSLIAS 487
Cdd:pfam01256 156 ILLKGNVTVIAAPGGeVWINSTGNSALAKGGSGDVLAGLIGGLLAQNEDPYDAAIAAAWLHGAASDLAAENHGV-YMLPT 234


                  ....*.
gi 2731057570 488 HVIDYL 493
Cdd:pfam01256 235 LLSKII 240
 
Name Accession Description Interval E-value
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 1-501 3.24e-121

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 364.96  E-value: 3.24e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570   1 MKIFSKEQIYAGDKLTAEKQQISSTDLMERAGTQIFNWMHMRMQGAQVPIHVFCGIGNNGGDGLVLARHLITHGYNVNTF 80
Cdd:COG0062     1 MKLLTAAQMRALDRAAIEALGIPGLVLMERAGRAVARAIRRRFPSAARRVLVLCGPGNNGGDGLVAARLLAEAGYNVTVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  81 IINCSDKRSKDFLINYDRIKNVTKKWpvlLSCAEDFPEINPDDIIVDAVFGIGLNRPVDEWVKNLFKHFRASKAFTLAID 160
Cdd:COG0062    81 LLGDPEKLSGDAAANLERLKAAGIPI---LELDDELPELAEADLIVDALFGTGLSRPLRGPYAELIEAINASGAPVLAVD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 161 IPSGLFPDKAiEDEDAVVWAGFTLSFASPKLVFFLPETAKYTVQWEVLDIGLDQEFLFTTETEVELIGKHEVLPnYIPRE 240
Cdd:COG0062   158 IPSGLDADTG-EVLGAAVRADLTVTFGAPKPGLLLGPGRDYCGELVVADIGIGIPAAAEAPAALLLLADLLALL-LPPRR 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 241 KFSHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITDTNEEKITSISFDIEPTV 320
Cdd:COG0062   236 RSHHKGGGGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAALLAALPEAMALALDDDEELLLLLAAAVVVA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 321 IGLGIGVGTDTDTIKAFEAFLKTNKAPLVIDADGINILSKKKTLLKLLPEATVLTPHPKELERLIGTWKDDFDKLKKVKT 400
Cdd:COG0062   316 GGGGGGGGGAGGGLLLLLLLLLLLLVLLAAALLLLLALAAALLLLLLLPPPLAAALLLLRLLTELLELRAAAAALLAAAA 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 401 FSKKHKLIIIIKGANTITVFEDKLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFGVYLHGKSADIAIEDFG 480
Cdd:COG0062   396 AAAAVAAAAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGLLAGAAAAAAAAAAAAAAAAAAAAAAAALA 475

                         490       500
                  ....*....|....*....|.
gi 2731057570 481 YQSLIASHVIDYLGEAYLDLF 501
Cdd:COG0062   476 AALLAAAAALIALLLAAALLL 496
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 224-502 4.94e-101

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 305.12  E-value: 4.94e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 224 VELIGKHEVLPNYIPREKFSHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITD 303
Cdd:COG0063     2 ARLLTPADLRALLPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVPESAAPAVAAALPELMVIPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 304 TNEEKItsISFDIEPTVIGLGIGVGTDTDTIKAFEAFLKTNKAPLVIDADGINILSKKKTLLKLLPEATVLTPHPKELER 383
Cdd:COG0063    82 PEEDEL--LELLERADAVVIGPGLGRDEETRELLRALLEAADKPLVLDADALNLLAEDPELLAALPAPTVLTPHPGEFAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 384 LIGTWKDD--FDKLKKVKTFSKKHKLIIIIKGANTITVFED-KLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTA 460
Cdd:COG0063   160 LLGCSVAEiqADRLEAAREAAKRYGAVVVLKGAGTVIAAPDgRVYINPTGNPGLATAGSGDVLAGIIAGLLAQGLDPFEA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2731057570 461 TIFGVYLHGKSADIAIEDFGYqSLIASHVIDYLGEAYLDLFK 502
Cdd:COG0063   240 AAAGVYLHGLAGDLAAEERGR-GLLASDLIEALPAALRELLE 280
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 243-493 3.11e-71

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 227.50  E-value: 3.11e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 243 SHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITDTNEEKITSISFDIEPTVIG 322
Cdd:cd01171     3 SHKGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATPPEAAAVIKSYSPELMVHPLLETDIEELLELLERADAVV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 323 LGIGVGTDTDTIKAFEAFLKTNKaPLVIDADGINIlSKKKTLLKLLPEATVLTPHPKELERLIG--TWKDDFDKLKKVKT 400
Cdd:cd01171    83 IGPGLGRDEEAAEILEKALAKDK-PLVLDADALNL-LADEPSLIKRYGPVVLTPHPGEFARLLGalVEEIQADRLAAARE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 401 FSKKHKLIIIIKGANTITVFED-KLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFGVYLHGKSADIAIEDF 479
Cdd:cd01171   161 AAAKLGATVVLKGAVTVIADPDgRVYVNPTGNPGLATGGSGDVLAGIIAALLAQGLSPLEAAALAVYLHGLAGDLAAKKK 240

                         250
                  ....*....|....
gi 2731057570 480 GYQSLIASHVIDYL 493
Cdd:cd01171   241 GAGLTAADLVAEIP 254
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 3-493 6.01e-52

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 184.49  E-value: 6.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570   3 IFSKEQIYAGDKLTAEKQQISSTDLMERAGTQIFNWMHMRMQGAQvpiH--VFCGIGNNGGDGLVLARHLITHGYNVnTF 80
Cdd:PRK10565   17 VWPADDIRRGEREAADALGLTLYELMLRAGEAAFQVARSAYPDAR---HwlVLCGHGNNGGDGYVVARLAQAAGIDV-TL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  81 IINCSDK---------RSKdFLINYDRIKNVTKKWPvllscaedfpeiNPDDIIVDAVFGIGLNRPVDEWVKNLFKHFRA 151
Cdd:PRK10565   93 LAQESDKplpeeaalaREA-WLNAGGEIHAADIVWP------------ESVDLIVDALLGTGLRQAPREPYAALIDQANA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 152 SKAFTLAIDIPSGLFPDKAIEdEDAVVWAGFTLSFASPKLVFFLPETAKYTVQWEVLDIGLdQEFLFTTETEVELIGKHE 231
Cdd:PRK10565  160 HPAPVVALDIPSGLLAETGAT-PGAVINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGL-DSWLAGQEAPIQRFDAEQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 232 vLPNYI-PREKFSHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITDTNEEKIT 310
Cdd:PRK10565  238 -LSQWLkPRRPTSHKGDHGRLLIIGGDHGTAGAIRMAGEAALRSGAGLVRVLTRSENIAPLLTARPELMVHELTPDSLEE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 311 SISFdiePTVIGLGIGVGTDTDTIKAFEAFLKTNKaPLVIDADGINIlskkktlLKLLPEAT---VLTPHPKELERLIGT 387
Cdd:PRK10565  317 SLEW---ADVVVIGPGLGQQEWGKKALQKVENFRK-PMLWDADALNL-------LAINPDKRhnrVITPHPGEAARLLGC 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 388 WKDDF--DKLKKVKTFSKKHKLIIIIKGANTITVFE-DKLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFG 464
Cdd:PRK10565  386 SVAEIesDRLLSARRLVKRYGGVVVLKGAGTVIAAEpDALAIIDVGNAGMASGGMGDVLSGIIGALLGQKLSPYDAACAG 465

                         490       500
                  ....*....|....*....|....*....
gi 2731057570 465 VYLHGKSADIAIEDFGYQSLIASHVIDYL 493
Cdd:PRK10565  466 CVAHGAAADVLAARFGTRGMLATDLFSTL 494
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 238-496 8.43e-51

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 174.49  E-value: 8.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 238 PREKFSHKGQFGHTLIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMV-----ITDTNEEKITSI 312
Cdd:TIGR00196  14 LRDPNSHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVAAPENVITLINSVSPELIVhrlmwKVDEDEELLERY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 313 SfdieptVIGLGIGVGTDTDTIKAFEAFLKTNKaPLVIDADGINILSKKKTLLkllpEATVLTPHPKELERLIGTWKDDF 392
Cdd:TIGR00196  94 D------VVVIGPGLGQDPSFKKAVEEVLELDK-PVVLDADALNLLTYNQKRE----GEVILTPHPGEFKRLLGVNEIQG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 393 DKLKKVKTFSKKHKLIIIIKGA-NTITVFEDKLYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFGVYLHGKS 471
Cdd:TIGR00196 163 DRLEAAQDIAQKLQAVVVLKGAaDVIAAPDGDLWINKTGNAALAKGGTGDVLAGLIGGLLAQNLDPFDAACNAAFAHGLA 242

                         250       260
                  ....*....|....*....|....*
gi 2731057570 472 ADIAIEDFGYQSLIASHVIDYLGEA 496
Cdd:TIGR00196 243 GDLALKNHGAYGLTALDLIEKIPRV 267
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 252-493 1.65e-40

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 146.35  E-value: 1.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 252 LIIGGSYGKIGAVTLASRAALSAGAGLISAFVPKCGYTPLQASFPEAMVITDTNEEKITSISFDIEptVIGLGIGVGTDT 331
Cdd:pfam01256   2 LVIGGSKDYTGAPLLAALAALRSGAGLVSVATDSEAIAVLKSPLPEVMVHPLPETSSILEKLSRYD--AVVIGPGLGRDE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 332 DTIKAFEAFLKTNKaPLVIDADGINILSKKKTLLKLLpEATVLTPHPKELERL---IGTWKDDfdKLKKVKTFSKKHKLI 408
Cdd:pfam01256  80 KGKAALEEVLAKDC-PLVIDADALNLLAINNEKPARE-GPTVLTPHPGEFERLcglAGILGDD--RLEAARELAQKLNGT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 409 IIIKGANTITVFEDK-LYVNTTGNPGLSTAGSGDVLTGIITGLISQNYHPLTATIFGVYLHGKSADIAIEDFGYqSLIAS 487
Cdd:pfam01256 156 ILLKGNVTVIAAPGGeVWINSTGNSALAKGGSGDVLAGLIGGLLAQNEDPYDAAIAAAWLHGAASDLAAENHGV-YMLPT 234


                  ....*.
gi 2731057570 488 HVIDYL 493
Cdd:pfam01256 235 LLSKII 240
YjeF_N pfam03853
YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a ...
 24-191 2.40e-37

YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.


Pssm-ID: 427546 [Multi-domain]  Cd Length: 168  Bit Score: 135.43  E-value: 2.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  24 STDLMERAGTQIFNWMHMRMQGAQVPIHVFCGIGNNGGDGLVLARHLITHGYNVNTFIINCSDKRSKDFLINYDRIKNVT 103
Cdd:pfam03853   1 SAVLMENAGRAAARVLKALLSPAGPKVLILCGPGNNGGDGLAAARHLANRGAKVTVLLLGPEEKLSEDARRQLDLFKKLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 104 KKWPVLLSCAEDFPEINPDDIIVDAVFGIGLNRPVDEWVKNLFKHFRASKAFTLAIDIPSGLFPDKAiEDEDAVVWAGFT 183
Cdd:pfam03853  81 GKIVTDNPDEDLEKLLSPVDLIIDALLGTGLSGPLRGEYAALIEWINQSGAPVLAVDIPSGLDADTG-AVLGTAVRADHT 159


                  ....*...
gi 2731057570 184 LSFASPKL 191
Cdd:pfam03853 160 VTFGAPKP 167
yjeF_nterm TIGR00197
yjeF N-terminal region; The protein region corresponding to this model shows no clear homology ...
 2-213 1.79e-28

yjeF N-terminal region; The protein region corresponding to this model shows no clear homology to any protein of known function. This model is built on yeast protein YNL200C and the N-terminal regions of E. coli yjeF and its orthologs in various species. The C-terminal region of yjeF and its orthologs shows similarity to hydroxyethylthiazole kinase (thiM) and other enzymes involved in thiamine biosynthesis. Yeast YKL151C and B. subtilis yxkO match the yjeF C-terminal domain but lack this region. [Unknown function, General]


Pssm-ID: 272956 [Multi-domain]  Cd Length: 205  Bit Score: 112.12  E-value: 1.79e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570   2 KIFSKEQIYAGDKLTAEKQQISSTDLMERAGTQIFnwmhmRMQGAQVP----IHVFCGIGNNGGDGLVLARHLIthGYNV 77
Cdd:TIGR00197   1 KVVVSPKDMAIDKENAEYLGLTLDLLMENAGKAVA-----QAVLQAYPlaghVIIFCGPGNNGGDGFVVARHLK--GFGV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  78 NTFIIncsdKRSKDFLINYDRIKNVtKKWPVLLSCAEDFPEINPD--DIIVDAVFGIGLNRPVDEWVKNLFKHFRASKAF 155
Cdd:TIGR00197  74 EVFLL----KKEKRIECTEQAEVNL-KALKVGGISIDEGNLVKPEdcDVIIDAILGTGFKGKLREPFKTIVESINELPAP 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2731057570 156 TLAIDIPSGLFPDKAiEDEDAVVWAGFTLSFASPKLVFFLPEtAKYTVQWEVLDIGLD 213
Cdd:TIGR00197 149 IVSVDIPSGLDVDTG-AIEGPAVNADLTITFHAIKPCLLSDR-ADVTGELKVGGIGIP 204
PLN03050 PLN03050
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 52-164 7.56e-14

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215551 [Multi-domain]  Cd Length: 246  Bit Score: 71.45  E-value: 7.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  52 VFCGIGNNGGDGLVLARHLITHGYNVNTFIINCSDKRSKDFLINYDRIKNVTKKWPVLLSCAEDFPEINPDDIIVDAVFG 131
Cdd:PLN03050   65 LVCGPGNNGGDGLVAARHLAHFGYEVTVCYPKQSSKPHYENLVTQCEDLGIPFVQAIGGTNDSSKPLETTYDVIVDAIFG 144

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2731057570 132 I---GLNR-PVDEWVKnLFKHFRASKAFTLAIDIPSG 164
Cdd:PLN03050  145 FsfhGAPRaPFDTLLA-QMVQQQKSPPPIVSVDVPSG 180
PLN03049 PLN03049
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 52-164 9.20e-12

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215550 [Multi-domain]  Cd Length: 462  Bit Score: 67.18  E-value: 9.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  52 VFCGIGNNGGDGLVLARHLITHGYNVNTfiinCSDKRSKDFLINYDRIKNVTKKWPVLLscAEDFPEINPD--DIIVDAV 129
Cdd:PLN03049   64 ALCGPGNNGGDGLVAARHLHHFGYKPSI----CYPKRTDKPLYNGLVTQLESLSVPFLS--VEDLPSDLSSqfDIVVDAM 137

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2731057570 130 FGI---GLNR-PVDEWVKNLFKhfRASKAFTLAIDIPSG 164
Cdd:PLN03049  138 FGFsfhGAPRpPFDDLIQKLVR--AAGPPPIVSVDIPSG 174
PLN02918 PLN02918
pyridoxine (pyridoxamine) 5'-phosphate oxidase
 52-191 4.84e-10

pyridoxine (pyridoxamine) 5'-phosphate oxidase


Pssm-ID: 215496 [Multi-domain]  Cd Length: 544  Bit Score: 61.88  E-value: 4.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570  52 VFCGIGNNGGDGLVLARHLITHGYnvNTFIinCSDKRSKDFLinYDRIKNVTKKWPVLLSCAEDFPE-INPD-DIIVDAV 129
Cdd:PLN02918  140 AICGPGNNGGDGLVAARHLHHFGY--KPFV--CYPKRTAKPL--YTGLVTQLESLSVPFVSVEDLPAdLSKDfDIIVDAM 213

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731057570 130 FGI---GLNR-PVDEWVKNLFK----HFRASKAFTLAIDIPSGLFPDKAiEDEDAVVWAGFTLSFASPKL 191
Cdd:PLN02918  214 FGFsfhGAPRpPFDDLIRRLVSlqnyEQTLKHPVIVSVDIPSGWHVEEG-DHEGGGIKPDMLVSLTAPKL 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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