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Conserved domains on  [gi|2731060520|ref|WP_345170426|]
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UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Algibacter aquimarinus]

Protein Classification

UDP-N-acetylglucosamine 1-carboxyvinyltransferase( domain architecture ID 12380807)

UDP-N-acetylglucosamine 1-carboxyvinyltransferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan

CATH:  3.65.10.10
EC:  2.5.1.7
Gene Ontology:  GO:0008760|GO:0019277|GO:0009252|GO:0008360|GO:0007049|GO:0051301|GO:0071555
SCOP:  4001425

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 1-434 0e+00

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440529  Cd Length: 416  Bit Score: 578.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQSDELD 80
Cdd:COG0766     1 MDKLIIEGGKPLSGEVRISGAKNAALPILAAALLTDGPVTLRNVPDLSDVRTMLELLESLGVKVERDDGGTLTIDASNIN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  81 LEYLESDqfkiDGRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYskEDQFYGVEADFLTG 160
Cdd:COG0766    81 STEAPYE----LVRKMRASILVLGPLLARFGEARVSLPGGCAIGARPIDLHLKGLEALGAEIEI--EHGYIEARAGRLKG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 161 TYMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTMLPDMI 240
Cdd:COG0766   155 ARIYLDFPSVGATENIMMAAVLAEGTTVIENAAREPEIVDLANFLNAMGAKIEGAGTDTITIEGVEKLHGAEHTVIPDRI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 241 EIGSWIGLAAMTKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIPAHTngyEIQnfidgsILTISDAPWPGFTPD 320
Cdd:COG0766   235 EAGTFLVAAAITGGDVTVKNVIPEHLEAVLAKLREAGVEIEEGDDGIRVRGPG---RLK------AVDIKTAPYPGFPTD 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 321 LLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKIILcDPHRATVIGhdfKSTLKATTMTSPDIRAGVSLLIAAL 400
Cdd:COG0766   306 LQAQFMALLTQAEGTSVITETVFENRFMHVDELNRMGADIKL-DGHTAIVRG---VTKLSGAPVMATDLRAGAALVLAGL 381

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2731060520 401 SAKGTSTIMNIEQIDRGYENIDERLRAIGAKITR 434
Cdd:COG0766   382 AAEGETVIDNIYHIDRGYENLEEKLRALGADIER 415
 
Name Accession Description Interval E-value
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 1-434 0e+00

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440529  Cd Length: 416  Bit Score: 578.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQSDELD 80
Cdd:COG0766     1 MDKLIIEGGKPLSGEVRISGAKNAALPILAAALLTDGPVTLRNVPDLSDVRTMLELLESLGVKVERDDGGTLTIDASNIN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  81 LEYLESDqfkiDGRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYskEDQFYGVEADFLTG 160
Cdd:COG0766    81 STEAPYE----LVRKMRASILVLGPLLARFGEARVSLPGGCAIGARPIDLHLKGLEALGAEIEI--EHGYIEARAGRLKG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 161 TYMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTMLPDMI 240
Cdd:COG0766   155 ARIYLDFPSVGATENIMMAAVLAEGTTVIENAAREPEIVDLANFLNAMGAKIEGAGTDTITIEGVEKLHGAEHTVIPDRI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 241 EIGSWIGLAAMTKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIPAHTngyEIQnfidgsILTISDAPWPGFTPD 320
Cdd:COG0766   235 EAGTFLVAAAITGGDVTVKNVIPEHLEAVLAKLREAGVEIEEGDDGIRVRGPG---RLK------AVDIKTAPYPGFPTD 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 321 LLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKIILcDPHRATVIGhdfKSTLKATTMTSPDIRAGVSLLIAAL 400
Cdd:COG0766   306 LQAQFMALLTQAEGTSVITETVFENRFMHVDELNRMGADIKL-DGHTAIVRG---VTKLSGAPVMATDLRAGAALVLAGL 381

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2731060520 401 SAKGTSTIMNIEQIDRGYENIDERLRAIGAKITR 434
Cdd:COG0766   382 AAEGETVIDNIYHIDRGYENLEEKLRALGADIER 415
PRK09369 PRK09369
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
 1-435 0e+00

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated


Pssm-ID: 236486  Cd Length: 417  Bit Score: 576.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQSDELD 80
Cdd:PRK09369    1 MDKLVIEGGKPLSGEVTISGAKNAALPILAASLLAEEPVTLTNVPDLSDVRTMIELLRSLGAKVEFDGNGTVTIDASNIN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  81 LEYLESDQfkidGRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYskEDQFYGVEAD-FLT 159
Cdd:PRK09369   81 NTEAPYEL----VKKMRASILVLGPLLARFGEAKVSLPGGCAIGARPVDLHLKGLEALGAEIEI--EHGYVEAKADgRLK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 160 GTYMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTMLPDM 239
Cdd:PRK09369  155 GAHIVLDFPSVGATENILMAAVLAEGTTVIENAAREPEIVDLANFLNKMGAKISGAGTDTITIEGVERLHGAEHTVIPDR 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 240 IEIGSWIGLAAMTKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIPAHTngyeiqnfiDGSILTISDAPWPGFTP 319
Cdd:PRK09369  235 IEAGTFLVAAAITGGDVTIRGARPEHLEAVLAKLREAGAEIEEGEDGIRVDMPG---------RLKAVDIKTAPYPGFPT 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 320 DLLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKIIlCDPHRATVIGhdfKSTLKATTMTSPDIRAGVSLLIAA 399
Cdd:PRK09369  306 DMQAQFMALLTQAEGTSVITETIFENRFMHVPELIRMGADIE-VDGHTAVVRG---VEKLSGAPVMATDLRASASLVLAG 381

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 2731060520 400 LSAKGTSTIMNIEQIDRGYENIDERLRAIGAKITRL 435
Cdd:PRK09369  382 LVAEGTTIVDRIYHLDRGYERIEEKLRALGADIERV 417
UdpNAET cd01555
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the ...
 12-428 5.77e-166

UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine. This enzyme is of interest as a potential target for anti-bacterial agents. The only other known enolpyruvyl transferase is the related 5-enolpyruvylshikimate-3-phosphate synthase.


Pssm-ID: 238796  Cd Length: 400  Bit Score: 472.34  E-value: 5.77e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  12 LKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQSDELDLEYLESDqfki 91
Cdd:cd01555     1 LSGEVRISGAKNAALPILAAALLTDEPVTLRNVPDLLDVETMIELLRSLGAKVEFEGENTLVIDASNINSTEAPYE---- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  92 DGRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYsKEDQFYGVEADFLTGTYMLLEEASVT 171
Cdd:cd01555    77 LVRKMRASILVLGPLLARFGEARVSLPGGCAIGARPVDLHLKGLEALGAKIEI-EDGYVEAKAAGRLKGARIYLDFPSVG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 172 GTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTMLPDMIEIGSWIGLAAM 251
Cdd:cd01555   156 ATENIMMAAVLAEGTTVIENAAREPEIVDLANFLNKMGAKIEGAGTDTIRIEGVERLHGAEHTVIPDRIEAGTFLVAAAI 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 252 TKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIPAHTngyeiqnfIDGSILTISDAPWPGFTPDLLSIILVVATQ 331
Cdd:cd01555   236 TGGDITVENVIPEHLEAVLAKLREMGAKIEIGEDGIRVDGDG--------GRLKAVDIETAPYPGFPTDLQAQFMALLTQ 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 332 ARGSVLIHQKMFESRLFFVDKLIDMGAKIILCDPHrATVIGHDFkstLKATTMTSPDIRAGVSLLIAALSAKGTSTIMNI 411
Cdd:cd01555   308 AEGTSVITETIFENRFMHVDELNRMGADIKVEGNT-AIIRGVTK---LSGAPVMATDLRAGAALVLAGLAAEGETIISNI 383

                         410
                  ....*....|....*..
gi 2731060520 412 EQIDRGYENIDERLRAI 428
Cdd:cd01555   384 YHIDRGYERIEEKLRAL 400
murA TIGR01072
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; [Cell envelope, Biosynthesis and ...
 1-434 7.68e-151

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 162190 [Multi-domain]  Cd Length: 416  Bit Score: 434.35  E-value: 7.68e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEklsrtsytFQSDELD 80
Cdd:TIGR01072   1 MDKLVVEGGKPLSGEVTISGAKNAALPIIAATLLTDEPVTLTNVPDLSDVKTTLDLLRNLGARVE--------RDNNTLE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  81 LEYLESDQFKID---GRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFrySKEDQFYGVEADF 157
Cdd:TIGR01072  73 INTPNINSTEAPyelVRKMRASILVLGPLLARFGKAVVSLPGGCAIGARPVDLHLKGLKALGAEI--VIEDGYVYASAKG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 158 -LTGTYMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTML 236
Cdd:TIGR01072 151 rLVGAHIVLDKVSVGATENIIMAAVLAEGTTVIENAAREPEIVDLCEFLNKMGAKITGAGSNTITIEGVEKLHGTEHSVI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 237 PDMIEIGSWIGLAAMTKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIpahtngyeIQNFIDGSILTISDAPWPG 316
Cdd:TIGR01072 231 PDRIEAGTFLVAAAITGGEITIKNVRPDHLRAVLAKLREIGAEVEVDENGIRV--------DMRQKRLKAVDIETLPYPG 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 317 FTPDLLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKIILCdPHRATVIGhdfKSTLKATTMTSPDIRAGVSLL 396
Cdd:TIGR01072 303 FPTDLQAQFMALLSQAEGTSVITETVFENRFMHVDELIRMGANIKLE-GNTAVIHG---VEQLSGAEVMATDLRAGAALV 378

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2731060520 397 IAALSAKGTSTIMNIEQIDRGYENIDERLRAIGAKITR 434
Cdd:TIGR01072 379 LAGLVAEGETIVHNVYHLDRGYEDLEEKLRALGAKIER 416
EPSP_synthase pfam00275
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
7-425 1.96e-57

EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);


Pssm-ID: 395213  Cd Length: 415  Bit Score: 194.44  E-value: 1.96e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   7 EGGHQLKGKIQPQG-AKNEALQILCAVLLTPElVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQSDELDLEYLE 85
Cdd:pfam00275   1 TGGSRLSGEVKIPGsKSNSHRALILAALAAGE-STITNLLDSDDTLTMLEALRALGAEIIKLDDEKSVVIVEGLGGSFEA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  86 SDQFKIDgrgLRGSIMIVGPLLARFG--KGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYSKEDQF--YGVEADFLTGT 161
Cdd:pfam00275  80 PEDLVLD---MGNSGTALRPLTGRLAlqSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYapLKVRGLRLGGI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 162 YMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGS-NMLIIDGVEYLGGTDHTMLPDMI 240
Cdd:pfam00275 157 HIDGDVSSQFVTSLLMLAALLAEGTTTIENLASEPYIDDTENMLKKFGAKIEGSGTeLSITVKGGEKLPGQEYRVEGDRS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 241 EIGSWIGLAAMTKSELTITNVSWNDL---GIIPNIFRKLGITVEKQGDDIHIpahtngyEIQNFIDGSILTISDAPWPGF 317
Cdd:pfam00275 237 SAAYFLVAAAITGGTVTVENVGINSLqgdEALLEILEKMGAEITQEEDADIV-------VGPPGLRGKAVDIRTAPDPAP 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 318 TPDLLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKiilCDPHRATVIGHDFKSTLK-ATTMTSPDIRAGVSLL 396
Cdd:pfam00275 310 TTAVLAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGAD---VEELPDGLIIIPAVKELKgAEVDSYGDHRIAMALA 386

                         410       420
                  ....*....|....*....|....*....
gi 2731060520 397 IAALSAKGTSTIMNIEQIDRGYENIDERL 425
Cdd:pfam00275 387 LAGLVAEGETIIDDIECTDRSFPDFEEKL 415
 
Name Accession Description Interval E-value
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 1-434 0e+00

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440529  Cd Length: 416  Bit Score: 578.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQSDELD 80
Cdd:COG0766     1 MDKLIIEGGKPLSGEVRISGAKNAALPILAAALLTDGPVTLRNVPDLSDVRTMLELLESLGVKVERDDGGTLTIDASNIN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  81 LEYLESDqfkiDGRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYskEDQFYGVEADFLTG 160
Cdd:COG0766    81 STEAPYE----LVRKMRASILVLGPLLARFGEARVSLPGGCAIGARPIDLHLKGLEALGAEIEI--EHGYIEARAGRLKG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 161 TYMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTMLPDMI 240
Cdd:COG0766   155 ARIYLDFPSVGATENIMMAAVLAEGTTVIENAAREPEIVDLANFLNAMGAKIEGAGTDTITIEGVEKLHGAEHTVIPDRI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 241 EIGSWIGLAAMTKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIPAHTngyEIQnfidgsILTISDAPWPGFTPD 320
Cdd:COG0766   235 EAGTFLVAAAITGGDVTVKNVIPEHLEAVLAKLREAGVEIEEGDDGIRVRGPG---RLK------AVDIKTAPYPGFPTD 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 321 LLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKIILcDPHRATVIGhdfKSTLKATTMTSPDIRAGVSLLIAAL 400
Cdd:COG0766   306 LQAQFMALLTQAEGTSVITETVFENRFMHVDELNRMGADIKL-DGHTAIVRG---VTKLSGAPVMATDLRAGAALVLAGL 381

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2731060520 401 SAKGTSTIMNIEQIDRGYENIDERLRAIGAKITR 434
Cdd:COG0766   382 AAEGETVIDNIYHIDRGYENLEEKLRALGADIER 415
PRK09369 PRK09369
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
 1-435 0e+00

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated


Pssm-ID: 236486  Cd Length: 417  Bit Score: 576.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQSDELD 80
Cdd:PRK09369    1 MDKLVIEGGKPLSGEVTISGAKNAALPILAASLLAEEPVTLTNVPDLSDVRTMIELLRSLGAKVEFDGNGTVTIDASNIN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  81 LEYLESDQfkidGRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYskEDQFYGVEAD-FLT 159
Cdd:PRK09369   81 NTEAPYEL----VKKMRASILVLGPLLARFGEAKVSLPGGCAIGARPVDLHLKGLEALGAEIEI--EHGYVEAKADgRLK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 160 GTYMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTMLPDM 239
Cdd:PRK09369  155 GAHIVLDFPSVGATENILMAAVLAEGTTVIENAAREPEIVDLANFLNKMGAKISGAGTDTITIEGVERLHGAEHTVIPDR 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 240 IEIGSWIGLAAMTKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIPAHTngyeiqnfiDGSILTISDAPWPGFTP 319
Cdd:PRK09369  235 IEAGTFLVAAAITGGDVTIRGARPEHLEAVLAKLREAGAEIEEGEDGIRVDMPG---------RLKAVDIKTAPYPGFPT 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 320 DLLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKIIlCDPHRATVIGhdfKSTLKATTMTSPDIRAGVSLLIAA 399
Cdd:PRK09369  306 DMQAQFMALLTQAEGTSVITETIFENRFMHVPELIRMGADIE-VDGHTAVVRG---VEKLSGAPVMATDLRASASLVLAG 381

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 2731060520 400 LSAKGTSTIMNIEQIDRGYENIDERLRAIGAKITRL 435
Cdd:PRK09369  382 LVAEGTTIVDRIYHLDRGYERIEEKLRALGADIERV 417
UdpNAET cd01555
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the ...
 12-428 5.77e-166

UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine. This enzyme is of interest as a potential target for anti-bacterial agents. The only other known enolpyruvyl transferase is the related 5-enolpyruvylshikimate-3-phosphate synthase.


Pssm-ID: 238796  Cd Length: 400  Bit Score: 472.34  E-value: 5.77e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  12 LKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQSDELDLEYLESDqfki 91
Cdd:cd01555     1 LSGEVRISGAKNAALPILAAALLTDEPVTLRNVPDLLDVETMIELLRSLGAKVEFEGENTLVIDASNINSTEAPYE---- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  92 DGRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYsKEDQFYGVEADFLTGTYMLLEEASVT 171
Cdd:cd01555    77 LVRKMRASILVLGPLLARFGEARVSLPGGCAIGARPVDLHLKGLEALGAKIEI-EDGYVEAKAAGRLKGARIYLDFPSVG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 172 GTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTMLPDMIEIGSWIGLAAM 251
Cdd:cd01555   156 ATENIMMAAVLAEGTTVIENAAREPEIVDLANFLNKMGAKIEGAGTDTIRIEGVERLHGAEHTVIPDRIEAGTFLVAAAI 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 252 TKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIPAHTngyeiqnfIDGSILTISDAPWPGFTPDLLSIILVVATQ 331
Cdd:cd01555   236 TGGDITVENVIPEHLEAVLAKLREMGAKIEIGEDGIRVDGDG--------GRLKAVDIETAPYPGFPTDLQAQFMALLTQ 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 332 ARGSVLIHQKMFESRLFFVDKLIDMGAKIILCDPHrATVIGHDFkstLKATTMTSPDIRAGVSLLIAALSAKGTSTIMNI 411
Cdd:cd01555   308 AEGTSVITETIFENRFMHVDELNRMGADIKVEGNT-AIIRGVTK---LSGAPVMATDLRAGAALVLAGLAAEGETIISNI 383

                         410
                  ....*....|....*..
gi 2731060520 412 EQIDRGYENIDERLRAI 428
Cdd:cd01555   384 YHIDRGYERIEEKLRAL 400
murA TIGR01072
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; [Cell envelope, Biosynthesis and ...
 1-434 7.68e-151

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 162190 [Multi-domain]  Cd Length: 416  Bit Score: 434.35  E-value: 7.68e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEklsrtsytFQSDELD 80
Cdd:TIGR01072   1 MDKLVVEGGKPLSGEVTISGAKNAALPIIAATLLTDEPVTLTNVPDLSDVKTTLDLLRNLGARVE--------RDNNTLE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  81 LEYLESDQFKID---GRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFrySKEDQFYGVEADF 157
Cdd:TIGR01072  73 INTPNINSTEAPyelVRKMRASILVLGPLLARFGKAVVSLPGGCAIGARPVDLHLKGLKALGAEI--VIEDGYVYASAKG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 158 -LTGTYMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTML 236
Cdd:TIGR01072 151 rLVGAHIVLDKVSVGATENIIMAAVLAEGTTVIENAAREPEIVDLCEFLNKMGAKITGAGSNTITIEGVEKLHGTEHSVI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 237 PDMIEIGSWIGLAAMTKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIpahtngyeIQNFIDGSILTISDAPWPG 316
Cdd:TIGR01072 231 PDRIEAGTFLVAAAITGGEITIKNVRPDHLRAVLAKLREIGAEVEVDENGIRV--------DMRQKRLKAVDIETLPYPG 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 317 FTPDLLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKIILCdPHRATVIGhdfKSTLKATTMTSPDIRAGVSLL 396
Cdd:TIGR01072 303 FPTDLQAQFMALLSQAEGTSVITETVFENRFMHVDELIRMGANIKLE-GNTAVIHG---VEQLSGAEVMATDLRAGAALV 378

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2731060520 397 IAALSAKGTSTIMNIEQIDRGYENIDERLRAIGAKITR 434
Cdd:TIGR01072 379 LAGLVAEGETIVHNVYHLDRGYEDLEEKLRALGAKIER 416
PRK12830 PRK12830
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed
 1-436 2.70e-94

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed


Pssm-ID: 183779  Cd Length: 417  Bit Score: 290.22  E-value: 2.70e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEklsRTSYTFQSDELD 80
Cdd:PRK12830    1 MEKIVINGGKPLSGEVTISGAKNSAVALIPAAILADGPVTLDGVPDISDVHSLVDILEELGGKVK---RDGDTLEIDPTG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  81 LEYLESDQFKIdgRGLRGSIMIVGPLLARFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYSKEDQFygVEADFLTG 160
Cdd:PRK12830   78 IQSMPLPNGKV--KSLRASYYFMGALLGRFKKAVVGLPGGCDLGPRPIDQHIKGFEALGAEVTNEGGAIY--LKADELKG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 161 TYMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTMLPDMI 240
Cdd:PRK12830  154 AHIYLDVVSVGATINIMLAAVKAKGRTVIENAAKEPEIIDVATLLNNMGANIKGAGTDVIRIEGVDELHGCRHTVIPDRI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 241 EIGSWIGLAAMTKSELTITNVSWNDLGIIPNIFRKLGITVEKQGDDIHIPAHTNGYEIqnfidgsilTISDAPWPGFTPD 320
Cdd:PRK12830  234 EAGTYMILAAACGGGVTINNVIPEHLESFIAKLEEMGVRVEVNEDSIFVEKQGNLKAV---------DIKTLPYPGFATD 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 321 LLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKIILcDPHRATVIGhdfKSTLKATTMTSPDIRAGVSLLIAAL 400
Cdd:PRK12830  305 LQQPLTPLLLKANGRSVVTDTIYEKRFKHVDELKRMGANIKV-EGRSAIITG---PSKLTGAKVKATDLRAGAALVIAGL 380

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 2731060520 401 SAKGTSTIMNIEQIDRGYENIDERLRAIGAKITRLE 436
Cdd:PRK12830  381 MAEGVTEITNIEHIDRGYSNIIEKLKALGADIWREE 416
EPSP_synthase pfam00275
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
7-425 1.96e-57

EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);


Pssm-ID: 395213  Cd Length: 415  Bit Score: 194.44  E-value: 1.96e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   7 EGGHQLKGKIQPQG-AKNEALQILCAVLLTPElVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQSDELDLEYLE 85
Cdd:pfam00275   1 TGGSRLSGEVKIPGsKSNSHRALILAALAAGE-STITNLLDSDDTLTMLEALRALGAEIIKLDDEKSVVIVEGLGGSFEA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  86 SDQFKIDgrgLRGSIMIVGPLLARFG--KGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYSKEDQF--YGVEADFLTGT 161
Cdd:pfam00275  80 PEDLVLD---MGNSGTALRPLTGRLAlqSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYapLKVRGLRLGGI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 162 YMLLEEASVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGS-NMLIIDGVEYLGGTDHTMLPDMI 240
Cdd:pfam00275 157 HIDGDVSSQFVTSLLMLAALLAEGTTTIENLASEPYIDDTENMLKKFGAKIEGSGTeLSITVKGGEKLPGQEYRVEGDRS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 241 EIGSWIGLAAMTKSELTITNVSWNDL---GIIPNIFRKLGITVEKQGDDIHIpahtngyEIQNFIDGSILTISDAPWPGF 317
Cdd:pfam00275 237 SAAYFLVAAAITGGTVTVENVGINSLqgdEALLEILEKMGAEITQEEDADIV-------VGPPGLRGKAVDIRTAPDPAP 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 318 TPDLLSIILVVATQARGSVLIHQKMFESRLFFVDKLIDMGAKiilCDPHRATVIGHDFKSTLK-ATTMTSPDIRAGVSLL 396
Cdd:pfam00275 310 TTAVLAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGAD---VEELPDGLIIIPAVKELKgAEVDSYGDHRIAMALA 386

                         410       420
                  ....*....|....*....|....*....
gi 2731060520 397 IAALSAKGTSTIMNIEQIDRGYENIDERL 425
Cdd:pfam00275 387 LAGLVAEGETIIDDIECTDRSFPDFEEKL 415
EPT-like cd01554
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine ...
 12-428 2.78e-55

Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer.


Pssm-ID: 238795  Cd Length: 408  Bit Score: 188.58  E-value: 2.78e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  12 LKGKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEkLSRTSYTFQSDELDLeyLESDQFKI 91
Cdd:cd01554     1 LHGIIRVPGDKSISHRSLIFASLAEGETKVYNILRGEDVLSTMQVLRDLGVEIE-DKDGVITIQGVGMAG--LKAPQNAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  92 D-GRGLRGSIMIVGPLLARfgKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYSKEDQF--YGVEADFLTGTYMLLEEA 168
Cdd:cd01554    78 NlGNSGTAIRLISGVLAGA--DFEVELFGDDSLSKRPMDRVTLPLKKMGASISGQEERDLppLLKGGKNLGPIHYEDPIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 169 SVTGTANIVMAAVLAKGQTTIYNAACEPYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTMLPDMIEIGSWIGL 248
Cdd:cd01554   156 SAQVKSALMFAALLAKGETVIIEAAKEPTINHTENMLQTFGGHISVQGTKKIVVQGPQKLTGQKYVVPGDISSAAFFLVA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 249 AAMTKSELTITNVSWN--DLGIIpNIFRKLGITVEKQGDDIHIPAHtngyeiqnfiDGSILTISDAPWPgFTPDLLSIIL 326
Cdd:cd01554   236 AAIAPGRLVLQNVGINetRTGII-DVLRAMGAKIEIGEDTISVESS----------DLKATEICGALIP-RLIDELPIIA 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 327 VVATQARGSVLIHQ------KMFESRLFFVDKLIDMGAKIilcDPHRATVIGHDFKSTLKATTMTSPDIRAGVSLLIAAL 400
Cdd:cd01554   304 LLALQAQGTTVIKDaeelkvKETDRIFVVADELNSMGADI---EPTADGMIIKGKEKLHGARVNTFGDHRIGMMTALAAL 380

                         410       420
                  ....*....|....*....|....*...
gi 2731060520 401 SAKGTSTIMNIEQIDRGYENIDERLRAI 428
Cdd:cd01554   381 VADGEVELDRAEAINTSYPSFFDDLESL 408
EPSP_synthase cd01556
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ...
 12-412 2.74e-16

EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.


Pssm-ID: 238797  Cd Length: 409  Bit Score: 80.29  E-value: 2.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  12 LKGKIQPQGAK---NEALqiLCAVLLTPElVTINNIPDIVDVNKLINLLKKLGVKVEKLSRT------SYTFQSDELDLE 82
Cdd:cd01556     1 LSGEITVPGSKsisHRAL--LLAALAEGE-SRIENLLDSDDTLATLEALRALGAKIEEEGGTveivggGGLGLPPEAVLD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  83 YLESdqfkidGRGLRgsimIVGPLLArFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYSKEDQF--YGVEADFLTG 160
Cdd:cd01556    78 CGNS------GTTMR----LLTGLLA-LQGGDSVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYppLIGGGGLKGG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 161 TYMLLEEAS---VTGtanIVMAAVLAKGQTTIYNAACE--PYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDHTM 235
Cdd:cd01556   147 EVEIPGAVSsqfKSA---LLLAAPLAEGPTTIIIGELEskPYIDHTERMLRAFGAEVEVDGYRTITVKGGQKYKGPEYTV 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 236 LPDmieIGS---WIGLAAMTKSELTITNVSWNDLGI-IPNIFRKLG--ITVEKQGDD-IHIPAHTNGYEiqnfIDGSILt 308
Cdd:cd01556   224 EGD---ASSaafFLAAAAITGSEIVIKNVGLNSGDTgIIDVLKEMGadIEIGNEDTVvVESGGKLKGID----IDGNDI- 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 309 isdapwpgftPDLLSIILVVATQARGSVLI----HQKMFES-RLF-FVDKLIDMGAKIILCD--------PHRATVIGHD 374
Cdd:cd01556   296 ----------PDEAPTLAVLAAFAEGPTRIrnaaELRVKESdRIAaMATELRKLGADVEETEdgliieggPLKGAGVEVY 365

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2731060520 375 fkstlkattmTSPDIRAGVSLLIAALSAKGTSTIMNIE 412
Cdd:cd01556   366 ----------TYGDHRIAMSFAIAGLVAEGGVTIEDPE 393
AroA COG0128
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ...
 1-412 1.69e-13

5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439898  Cd Length: 421  Bit Score: 71.66  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAK---NEALqILCAvlLTPELVTINNIPDIVDVNKLINLLKKLGVKVEKLSRTSYTFQS- 76
Cdd:COG0128     1 MSSLTIAPPSPLKGTVRVPGSKsisHRAL-LLAA--LAEGESTIRNLLESDDTLATLEALRALGAEIEELDGGTLRVTGv 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  77 --------DELDLeylesdqfkidgrGLRGSIM-IVGPLLARFGKGYIPKpgGDK-IGRRRLDTHFEGLIKLGAKFRYSK 146
Cdd:COG0128    78 ggglkepdAVLDC-------------GNSGTTMrLLTGLLALQPGEVVLT--GDEsLRKRPMGRLLDPLRQLGARIESRG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 147 EDQF----YGveADFLTGTYMLLEEAS---VTGtanIVMAAVLAKGQTTIYNAAC---EPYLQQLCKMLNRMGAKISGVG 216
Cdd:COG0128   143 GGYLpltiRG--GPLKGGEYEIPGSASsqfKSA---LLLAGPLAEGGLEITVTGElesKPYRDHTERMLRAFGVEVEVEG 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 217 SNMLIIDGVEYLGGTDHTMLPDmieIGS---WIGLAAMTKSELTITNVSWN----DLGIIpNIFRKLGITVEKQGDDIHI 289
Cdd:COG0128   218 YRRFTVPGGQRYRPGDYTVPGD---ISSaafFLAAAAITGSEVTVEGVGLNstqgDTGIL-DILKEMGADIEIENDGITV 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 290 -PAHTNGYEIqnfiDGSIltisdapwpgfTPDLLSIILVVATQARG-SVLI---HQKMFES-RLF-FVDKLIDMGAKIil 362
Cdd:COG0128   294 rGSPLKGIDI----DLSD-----------IPDEAPTLAVLAAFAEGtTRIRgaaELRVKESdRIAaMATELRKLGADV-- 356

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2731060520 363 cdphratVIGHDF-----KSTLKATTMTS-PDIRAGVSLLIAALSAKGTSTIMNIE 412
Cdd:COG0128   357 -------EETEDGliiegGPKLKGAEVDSyGDHRIAMAFAVAGLRAEGPVTIDDAE 405
aroA TIGR01356
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ...
 14-431 1.85e-10

3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273574  Cd Length: 409  Bit Score: 62.29  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  14 GKIQPQGAKNEALQILCAVLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEKlsrtsytfqsdeldleylESDQFKIDG 93
Cdd:TIGR01356   1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIED------------------GGEVAVIEG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  94 RGLR-----------GSIM-IVGPLLArFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYSKEDQFY--GVEADFLT 159
Cdd:TIGR01356  63 VGGKepqaeldlgnsGTTArLLTGVLA-LADGEVVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLplTISGPLPG 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 160 GTYMLLEEAS---VTGtanIVMAAVLAKGQTTIYNAACE---PYLQQLCKMLNRMGAKISGVGSNMLIIDGVEYLGGTDH 233
Cdd:TIGR01356 142 GIVYISGSASsqyKSA---LLLAAPALQAVGITIVGEPLksrPYIEITLDLLGSFGVEVERSDGRKIVVPGGQKYGPQGY 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 234 TMLPDMIEIGSWIGLAAMTKSELTITNVSWNDL---GIIPNIFRKLGITVEKQGDDIHIPAHTNGYEIQnfIDgsiltIS 310
Cdd:TIGR01356 219 DVPGDYSSAAFFLAAAAITGGRVTLENLGINPTqgdKAIIIVLEEMGADIEVEEDDLIVEGASGLKGIK--ID-----MD 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 311 DAPwpgftpDLLSIILVVATQARG-SVLI---HQKMFES-RL-FFVDKLIDMGAKiilCDPhratviGHDF-----KSTL 379
Cdd:TIGR01356 292 DMI------DELPTLAVLAAFAEGvTRITgaeELRVKESdRIaAIAEELRKLGVD---VEE------FEDGlyirgKKEL 356

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2731060520 380 K-ATTMTSPDIRAGVSLLIAALSAKGTSTIMNIEQIDRGYENIDERLRAIGAK 431
Cdd:TIGR01356 357 KgAVVDTFGDHRIAMAFAVAGLVAEGEVLIDDPECVAKSFPSFFDVLERLGAN 409
PRK02427 PRK02427
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 1-432 8.17e-08

3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 235037 [Multi-domain]  Cd Length: 435  Bit Score: 53.99  E-value: 8.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520   1 MGTFKIEGGHQLKGKIQPQGAK---NEALqiLCAvLLTPELVTINNIPDIVDVNKLINLLKKLGVKVEklsRTSYTFQSd 77
Cdd:PRK02427    2 MMMLLIIPPSPLSGTVRVPGSKsisHRAL--LLA-ALAEGETTITNLLRSEDTLATLNALRALGVEIE---DDEVVVEG- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520  78 eLDLEYLESDQFKID----GRGLRgsIMIvgPLLArFGKGYIPKPGGDKIGRRRLDTHFEGLIKLGAKFRYSKEDQfygv 153
Cdd:PRK02427   75 -VGGGGLKEPEDVLDcgnsGTTMR--LLT--GLLA-LQPGEVVLTGDESLRKRPMGRLLDPLRQMGAKIEGRDEGY---- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 154 eADF-LTGTYML------LEEAS--VTGtanIVM-AAVLAKGQTTIY---NAACEPYLQQLCKMLNRMGAKISGVGSNM- 219
Cdd:PRK02427  145 -LPLtIRGGKKGgpieydGPVSSqfVKS---LLLlAPLFAEGDTETTviePLPSRPHTEITLRMLRAFGVEVENVEGWGy 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 220 --LIIDGVEYLGGTDHTMLPDmieIGS---WIGLAAMT-KSELTITNVSWNDL---GIIPNIFRKLG--ITVEKQ----- 283
Cdd:PRK02427  221 rrIVIKGGQRLRGQDITVPGD---PSSaafFLAAAAITgGSEVTITNVGLNSTqggKAIIDVLEKMGadIEIENEregge 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 284 -GDDIHI-PAHTNGYEIqnfidgsiltisDAPWpgfTPDLLSIILVVATQARG-SVLI---HQKMFES-RLF-FVDKLID 355
Cdd:PRK02427  298 pVGDIRVrSSELKGIDI------------DIPD---IIDEAPTLAVLAAFAEGtTVIRnaeELRVKETdRIAaMATELRK 362

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 356 MGAK--------IILCDPHRATVIGHDfkstlkattmtspDIRAGVSLLIAALSAKGTSTIMNIEQIDRGYENIDERLRA 427
Cdd:PRK02427  363 LGAEveetedglIITGGPLAGVVDSYG-------------DHRIAMAFAIAGLAAEGPVTIDDPECVAKSFPDFFEDLAS 429


                  ....*
gi 2731060520 428 IGAKI 432
Cdd:PRK02427  430 LGANI 434
EPSP_synthase cd01556
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ...
 248-434 2.37e-05

EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.


Pssm-ID: 238797  Cd Length: 409  Bit Score: 46.40  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 248 LAAMTKSELTITNVSWND--LGIIpNIFRKLGITVEKQGDDIHIpaHTNGyeIQNFIDGSILTISDApwpGFTPDLLSII 325
Cdd:cd01556    20 LAALAEGESRIENLLDSDdtLATL-EALRALGAKIEEEGGTVEI--VGGG--GLGLPPEAVLDCGNS---GTTMRLLTGL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 326 LvvATQARGSVLI-HQKMFE---SRLffVDKLIDMGAKII-LCDPHRATVIGHdfkSTLKATTMTspdIRAGVS------ 394
Cdd:cd01556    92 L--ALQGGDSVLTgDESLRKrpmGRL--VDALRQLGAEIEgREGGGYPPLIGG---GGLKGGEVE---IPGAVSsqfksa 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2731060520 395 LLIAALSAKGTSTIMNIEQIDRGYENIDER-LRAIGAKITR 434
Cdd:cd01556   162 LLLAAPLAEGPTTIIIGELESKPYIDHTERmLRAFGAEVEV 202
PRK02427 PRK02427
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 205-433 2.16e-04

3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 235037 [Multi-domain]  Cd Length: 435  Bit Score: 43.21  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 205 LNRMGAKISGVGSNM--LIIDGVEYLGGtdhtmlpdmIEIGSWI------------GLAAMTKSELTITN--VSWNDLGI 268
Cdd:PRK02427  130 LRQMGAKIEGRDEGYlpLTIRGGKKGGP---------IEYDGPVssqfvksllllaPLFAEGDTETTVIEplPSRPHTEI 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 269 IPNIFRKLGITVEKQGDDIHIPAHTNG---YEIQNFI---DGSiltiSDAPWpgftpdllsiiLVVATQARGS-VLIHQK 341
Cdd:PRK02427  201 TLRMLRAFGVEVENVEGWGYRRIVIKGgqrLRGQDITvpgDPS----SAAFF-----------LAAAAITGGSeVTITNV 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731060520 342 MFESR---LFFVDKLIDMGAKIILCDPHRATVIGHDF---KSTLKATTMTSPD-IRAGVSLLIAALSAKGTSTIMNIEQI 414
Cdd:PRK02427  266 GLNSTqggKAIIDVLEKMGADIEIENEREGGEPVGDIrvrSSELKGIDIDIPDiIDEAPTLAVLAAFAEGTTVIRNAEEL 345

                         250       260
                  ....*....|....*....|....
gi 2731060520 415 -----DRgYENIDERLRAIGAKIT 433
Cdd:PRK02427  346 rvketDR-IAAMATELRKLGAEVE 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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