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Conserved domains on  [gi|2731170960|ref|WP_345278341|]
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outer membrane beta-barrel protein [Litoribaculum gwangyangense]

Protein Classification

porin family protein( domain architecture ID 229388)

porin family protein is a member of a large superfamily consisting of classical (gram-negative ) porins which are non-specific channels for small hydrophillic molecules, maltoporin-like channels which have specificities for various sugars, and ligand-gated protein channels which cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OM_channels super family cl21487
Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in ...
 35-179 7.63e-06

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20), which associate as trimers. Maltoporin-like channels have specificities for various sugars and form 18 beta-stranded barrels (18,22), which associate as trimers. Ligand-gated protein channels cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force and they form monomeric, (22,24) barrels. The 150-200 N-terminal residues form a plug that blocks the channel from the periplasmic end.


The actual alignment was detected with superfamily member pfam13568:

Pssm-ID: 473880  Cd Length: 175  Bit Score: 44.70  E-value: 7.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731170960  35 FAQTATG---FGLKGGLNYNAngdyFESIGSNARNPDRNIGYHFGVFGKI--GKQVYFRPELVYSSTKSDYNDD------ 103
Cdd:pfam13568   1 FAQSRRRrleIGVKGGFNASK----LSPEPRNISDYNPRGGFSVGVIVRYrlNNRWGFQPGLGYSNRGWEFEFEvetssg 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731170960 104 -----SFKMQKLDAPMLVGLKVIGP----VSIFGGPSFQYILDTEFEGIA----------IREVANDFTVGLNFGIGLNL 164
Cdd:pfam13568  77 dtyktKRTSTYLELPLLAKYRFGKSnnvrLFFQAGPKLGYLLGGKFSGTDsdvtdsdasyDTDKLRKFDYGLVIGAGLEF 156

                         170
                  ....*....|....*.
gi 2731170960 165 -NKLGIDLRYERGFNN 179
Cdd:pfam13568 157 fNRLTLELRYYYGLND 172
 
Name Accession Description Interval E-value
OMP_b-brl_2 pfam13568
Outer membrane protein beta-barrel domain; This domain is found in a wide range of outer ...
 35-179 7.63e-06

Outer membrane protein beta-barrel domain; This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.


Pssm-ID: 433316  Cd Length: 175  Bit Score: 44.70  E-value: 7.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731170960  35 FAQTATG---FGLKGGLNYNAngdyFESIGSNARNPDRNIGYHFGVFGKI--GKQVYFRPELVYSSTKSDYNDD------ 103
Cdd:pfam13568   1 FAQSRRRrleIGVKGGFNASK----LSPEPRNISDYNPRGGFSVGVIVRYrlNNRWGFQPGLGYSNRGWEFEFEvetssg 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731170960 104 -----SFKMQKLDAPMLVGLKVIGP----VSIFGGPSFQYILDTEFEGIA----------IREVANDFTVGLNFGIGLNL 164
Cdd:pfam13568  77 dtyktKRTSTYLELPLLAKYRFGKSnnvrLFFQAGPKLGYLLGGKFSGTDsdvtdsdasyDTDKLRKFDYGLVIGAGLEF 156

                         170
                  ....*....|....*.
gi 2731170960 165 -NKLGIDLRYERGFNN 179
Cdd:pfam13568 157 fNRLTLELRYYYGLND 172
 
Name Accession Description Interval E-value
OMP_b-brl_2 pfam13568
Outer membrane protein beta-barrel domain; This domain is found in a wide range of outer ...
 35-179 7.63e-06

Outer membrane protein beta-barrel domain; This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.


Pssm-ID: 433316  Cd Length: 175  Bit Score: 44.70  E-value: 7.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731170960  35 FAQTATG---FGLKGGLNYNAngdyFESIGSNARNPDRNIGYHFGVFGKI--GKQVYFRPELVYSSTKSDYNDD------ 103
Cdd:pfam13568   1 FAQSRRRrleIGVKGGFNASK----LSPEPRNISDYNPRGGFSVGVIVRYrlNNRWGFQPGLGYSNRGWEFEFEvetssg 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731170960 104 -----SFKMQKLDAPMLVGLKVIGP----VSIFGGPSFQYILDTEFEGIA----------IREVANDFTVGLNFGIGLNL 164
Cdd:pfam13568  77 dtyktKRTSTYLELPLLAKYRFGKSnnvrLFFQAGPKLGYLLGGKFSGTDsdvtdsdasyDTDKLRKFDYGLVIGAGLEF 156

                         170
                  ....*....|....*.
gi 2731170960 165 -NKLGIDLRYERGFNN 179
Cdd:pfam13568 157 fNRLTLELRYYYGLND 172
OMP_b-brl pfam13505
Outer membrane protein beta-barrel domain; This domain is found in a wide range of outer ...
 22-175 7.10e-03

Outer membrane protein beta-barrel domain; This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.


Pssm-ID: 463903 [Multi-domain]  Cd Length: 175  Bit Score: 35.84  E-value: 7.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731170960  22 FFILLVTIIPATSFAQTA-TGFGLKGGLNYnangdyfesIGSNARNPDRNIGYHFGVFG--KIGKQVYFRPELVYSSTKS 98
Cdd:pfam13505   1 AALLLLAAFSAAAAAAEEfGGFYVGGGLGN---------ANFSFDGDGTDSGGGFGVGAgyDFNDYLGVEGELGYGSDDD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731170960  99 DYNDD--SFKMQKLDAPMLVGLKV-IGP-VSIFGGPSFQYI-LDTEFEGIAIREVANDFTVGLNFGIGLNlNKLGIDLRY 173
Cdd:pfam13505  72 YSGGGntDANIRSLSIGVNLGYRFpLSDsLLPYGGAGYGYSkLEGDYNGVSDSGTDFGFGYGAGVEYALT-DHLAVRAEY 150


                  ..
gi 2731170960 174 ER 175
Cdd:pfam13505 151 RY 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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