|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
6-499 |
1.27e-158 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 459.96 E-value: 1.27e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 6 SNRWLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIF 85
Cdd:PRK14995 2 FRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 86 CAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWG 165
Cdd:PRK14995 82 GLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 166 SVFLINVPVMLLVIPLVIAYIPRRSVVGDGNWTIGQSLILILGVMASVYALKSAFKTNSSVFVTGACFVFGALMLVWFVR 245
Cdd:PRK14995 162 SVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 246 KQLHTTTPMLDLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVILKA 325
Cdd:PRK14995 242 TQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 326 IGLRWVASCSLLVSAVSLVGLAQIHLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTG 405
Cdd:PRK14995 322 LGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAG 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 406 LGITVFGILLVSTYEKSIQLPDGIPSAMAETAVRSIGETMIAAKTLGGIQGQQLAAAGQKAFSASHSMVLLTAAALVGAL 485
Cdd:PRK14995 402 LGIAIFGLLLSRSYSASIRLPAGLPAQLIEKASSSIGEAVQLANSLPPTLGQALLDAAKQAFIWSHSVVLSSAGSMLLLL 481
|
490
....*....|....
gi 2731878392 486 SLLVWFVLKHHKNR 499
Cdd:PRK14995 482 AVGVWFSLAKAQRR 495
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-448 |
2.25e-59 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 200.09 E-value: 2.25e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 15 VILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAF 94
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 95 SPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDqSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPV 174
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPG-ERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 175 MLLVIPLviayiprrsvvgdgnwtigqslililgvmasvyalksafktnssvfvtgacfvfgalmlvwfvrkqlhtttpm 254
Cdd:cd17321 160 GLVALLL------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 255 ldlslfsIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVILKAIGLRWVASC 334
Cdd:cd17321 167 -------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 335 SLLVSAVSLVGLAQIHLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLGITVFGIL 414
Cdd:cd17321 240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
410 420 430
....*....|....*....|....*....|....*.
gi 2731878392 415 LVSTYEKSI--QLPDGIPSAMAETAVRSIGETMIAA 448
Cdd:cd17321 320 LTAGLSANLgdSGVAALLSAAAAAFAAGFHLAFLVA 355
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-415 |
2.06e-41 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 152.34 E-value: 2.06e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 15 VILAFMPIvLDYTILHVAVPSLTLALQATGTEILWIIDIYpLLMASLLIPM-GTLADRVGHRRMLLAGLGIFCAGSVLAA 93
Cdd:cd17503 2 LLGAFMAI-LDTTIVNVALPTIMGDLGASLDTVQWVITSY-LLALAIMIPLsGWLADRFGTRRLFLTALALFTLGSLLCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 94 FSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFeDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVP 173
Cdd:cd17503 80 LAPNLASLIIFRILQGFGGGVLIPLAQTILLRIY-PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 174 VMLLVIplviayiprrsvvgdgnwtigqslililgvmasvyalksafktnssvfvtgacfvfgalmlvwfvrkqlhTTTP 253
Cdd:cd17503 159 IGILAL----------------------------------------------------------------------LLAP 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 254 MLDLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVILKAIGLRWVAS 333
Cdd:cd17503 169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 334 CSLLVSAVSLVGLAQIHLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLGITVFGI 413
Cdd:cd17503 249 AGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLAT 328
|
..
gi 2731878392 414 LL 415
Cdd:cd17503 329 LL 330
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
10-491 |
1.48e-40 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 152.53 E-value: 1.48e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 10 LVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGS 89
Cdd:TIGR00711 2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 90 VLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFL 169
Cdd:TIGR00711 82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEK-RGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 170 INVPVMLLVIPLVIAYIPRRSVVGDGNWTIGQSLILILGVMASVYALKSAFK--TNSSVFVTGACFVfGALMLVWFVRKQ 247
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPErgWFDSNEILILSIT-GLVAIIAFVVWE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 248 LHTTTPMLDLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVILKAIG 327
Cdd:TIGR00711 240 LTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKID 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 328 LRWVASCSLLVSAVSLVGLA-QIHLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGL 406
Cdd:TIGR00711 320 PRKLVTIGLILYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 407 GITVFGILLVSTYEKSIQLPDGIPSAMAETAVRSIGETMIAAKTLGGIQGQQLAAAGQKAFSASHSMVLLTAAALVGALS 486
Cdd:TIGR00711 400 GTALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALGNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGL 479
|
....*
gi 2731878392 487 LLVWF 491
Cdd:TIGR00711 480 ILIWF 484
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-287 |
5.07e-30 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 118.76 E-value: 5.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 6 SNRWLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIF 85
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 86 CAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQsDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWG 165
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPAR-ERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 166 SVFLINVPVMLLVIPLVIAYIPRRSVVGDGNWTIGQSLILILGVMASVYALKSAFKTNSSVFVTGACFVFGALMLVWFVR 245
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2731878392 246 KQLHTTTPMLDLSLFSIPAVSTGIVMALVTMGALAGFELLLA 287
Cdd:COG0477 249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-406 |
2.73e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.15 E-value: 2.73e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 1 MSNGNSNRWLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLA 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 81 GLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQsDQAVALGIWGAVASTGAAIGPLVGGALLE 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPE-RRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 161 HFWWGSVFLINVPVMLLVIPLVIAYIPRRSVVGDGNWTIGQslililgvmasvyalksafktnssvfvtgacfvfgalml 240
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL--------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 241 vwfvrkqlhtttpmldLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAG 320
Cdd:COG2814 201 ----------------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 321 VILKAIGLRWVASCSLLVSAVSLVGLAqihLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSY 400
Cdd:COG2814 265 RLADRFGRRRLLLIGLLLLALGLLLLA---LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
....*.
gi 2731878392 401 DLGTGL 406
Cdd:COG2814 342 FLGGPL 347
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
12-417 |
3.16e-26 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 109.97 E-value: 3.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 12 LMSVILAFMpivLDYTILHVAVPSLTLALQATGTEILWIIDIYpLLMASLLIP-MGTLADRVGHRRMLLAGLGIFCAGSV 90
Cdd:cd17504 1 LALAALAVM---LVETMLSPALPTIQREFGTSAAAVSWVLTAY-LLVGAVSTPiLGRLGDLYGRKKVLLIVLAIYTAGSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 91 LAAFSPNVGSLIGARAFMAFGGAMVmPSVLAIIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLI 170
Cdd:cd17504 77 LAAFAPNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPER-VPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 171 NVPVMLLVIPLViayiprrsvvgdgnwtigqslililgvmasvyalksafktnssvfvtgacfvfgalmlvwfvrkqlht 250
Cdd:cd17504 155 AAPVAVLLAALV-------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 251 ttPMLDLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVME----RTPLEAGIFMMPLMIAAAIGGPLAGVILKAI 326
Cdd:cd17504 167 --PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPtgfgLGITEAGLLLLPGALVMLIAGPLAGRLIARV 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 327 GLRWVASCSLLVSAVSLVGLAQIHLGSGGVAVIVMLVALGLSLSigLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGL 406
Cdd:cd17504 245 GPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLA--FASLPNIVVESVPPDRTGIATGMNTVLRTIGSAI 322
|
410
....*....|.
gi 2731878392 407 GITVFGILLVS 417
Cdd:cd17504 323 GPAIAGAILTT 333
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
24-410 |
7.99e-26 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 108.03 E-value: 7.99e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 24 LDYTILHVAVPSLTLALQAtGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIG 103
Cdd:cd17502 10 LDQTIVATALPTIVAEFGG-LSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 104 ARAFMAFGGAMVMPSVLAIIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLvi 183
Cdd:cd17502 89 GRAIQGIGGGGLMSLAFIIIADLVPPRE-RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALAL-- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 184 ayiprrsvvgdgnwtigqslililgvmasvyalksafktnssvfvtgacfvfgalmlvwfvrkqlhtttpmldlslfsIP 263
Cdd:cd17502 166 ------------------------------------------------------------------------------LR 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 264 AVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVIL-KAIGLRWVASCSLLVSAVS 342
Cdd:cd17502 168 TILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALIsKTGRYKPLIVIGTILMSVG 247
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2731878392 343 LVGLAQIHLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLGITV 410
Cdd:cd17502 248 AGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-344 |
1.02e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 102.26 E-value: 1.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 8 RWLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCA 87
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 88 GSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFeDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSV 167
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 168 FLINVPVMLLVIPLVIAYIPRRSVVGDGNWTIGQSLILILGVMASVYALKSAFKTNSSVFVTGA--CFVFGALMLVWFVR 245
Cdd:COG2271 167 FLILGLPGLLLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIvgSLLGGWLSDRLGRR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 246 KQLHTTTPMLDLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQF--VMERTPLEA-----GIFMMPLMIAAAIGGPL 318
Cdd:COG2271 247 RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWalAAELFPKKArgtasGLVNTFGFLGGALGPLL 326
|
330 340
....*....|....*....|....*.
gi 2731878392 319 AGVILKAIGLRWVASCSLLVSAVSLV 344
Cdd:COG2271 327 VGYLLDATGYQAAFLLLAALALLAAL 352
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-414 |
1.28e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.19 E-value: 1.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 15 VILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAF 94
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 95 SPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPV 174
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE-RGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 175 MLLVIPLVIAYIPRRSVVGDGNWTIGQSLILILgvmasvyalksafktnssvfvtgacfvfgalmlvwfvrkqlhtttpm 254
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGL----------------------------------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 255 ldLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVILKAIGLRWVASC 334
Cdd:cd17325 193 --RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 335 SLLVSAVSLVGLAqihLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLGITVFGIL 414
Cdd:cd17325 271 GLLLSAVALLLLP---LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
14-492 |
1.01e-20 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 95.00 E-value: 1.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 14 SVILAFMPIVLDYTILHVAVPSLTLALQATgTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAA 93
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 94 FSPNVGSLIGARAF--MAFGGAMVMPSVLA--IIRQTfedqsdQAVALGIWGAVASTGAAIGPLVGGALLEHFW--WGSV 167
Cdd:cd06179 81 TAKSVNMLIGGQALigIGAGTQGLGAAVASelVPNKY------RGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 168 FLINVPVMLL-VIPLVIAYIPRRSVVGDGNWT---------------IGQSLILILGVM--ASVYALKSAfkTNSSVFVT 229
Cdd:cd06179 155 FYINAIFNALaLILLFFFYHPPPRPQLHGSSTrqklkrldwvglfllIAGLVLFLLGLSwgGNPYPWSSA--HVIAPLVI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 230 GACFVFGALMLVWFVRKQlhttTPMLDLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLM 309
Cdd:cd06179 233 GGVLLIAFGLYEWKGTKD----GLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFG 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 310 IAAAIGGPLAGVILKAIG-LRWVASCSLLVSAVSLVGLAQIHLGSGGVAvIVMLVALGLSLSIGLTASSVAIMNSIPMEK 388
Cdd:cd06179 309 LGTLFGAILAGLLLTKIKhIKWQLVAGFVLFTAFLALLALITPDNKALA-IAFSVLAGIGIGGPLVLAIVIVQLSVPPED 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 389 AGSAGALEATSYDLGTGLGITVFGILLVSTYEKsiQLPDGIPSAMAETAVR-SIGETMIAAKTLGGIQG----------- 456
Cdd:cd06179 388 IGTASGLLGSARALGGAVGTAIFTSILSNRLSK--NLPARVAPAALEAGLPaSSLPALLGALASGNIAAltavpginpei 465
|
490 500 510
....*....|....*....|....*....|....*..
gi 2731878392 457 -QQLAAAGQKAFSASHSMVLLTAAALVGALSLLVWFV 492
Cdd:cd06179 466 iAAATAALKQAYADSFRYVWYAAIPFGVVAIIAALFL 502
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-418 |
2.42e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 89.94 E-value: 2.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 6 SNRWLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIF 85
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 86 CAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEHFWWG 165
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR-RGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 166 SVFLINVPVMLLVIPLVIAYIPRRSVVGDGnwtigqslililGVMASVYALKSAFKTnssvfvtgacfvfgalmlvwfvr 245
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAA------------AAKASLRDQLEALRD----------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 246 kqlhtttpmldlslfsiPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVILKA 325
Cdd:COG2223 205 -----------------PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 326 IGLRWVASCSLLVSAVSLVGLAQIHLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNsiPMEKAGSAGALEATSYDLGTG 405
Cdd:COG2223 268 IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF--PTKNAGAVYGLVGAAGGLGGF 345
|
410
....*....|...
gi 2731878392 406 LGITVFGILLVST 418
Cdd:COG2223 346 LGPLLFGALLDAT 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-407 |
8.11e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.86 E-value: 8.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 15 VILAFMPIVLDYTILHVAVPS-LTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 94 FSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDqSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVP 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 174 VMLLVIPLVIAYIPRRSVVGDGnwtiGQSLILILGVMASVYALKSAFKTNSSVFVTGACFVFGALMLVWFVRKQLHTttp 253
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPK----PAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL--- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 254 mldlslfsipavstgivmalvtmgalagfelllaqelqfvmerTPLEAGIFMMPLMIAAAIGGPLAGVILKAIGLRWVAS 333
Cdd:pfam07690 233 -------------------------------------------SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2731878392 334 CSLLVSAVSLVGLAQIHLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLG 407
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
31-186 |
5.86e-18 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 85.39 E-value: 5.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 31 VAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAF 110
Cdd:cd17476 19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2731878392 111 GGAMVMPSVLAIIRQTFEDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINvpVMLLVIPLVIAYI 186
Cdd:cd17476 99 GPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL--AILAAIVAVAAIF 172
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
1-415 |
1.08e-17 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 85.55 E-value: 1.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 1 MSNGNSNRWLvLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLA 80
Cdd:PRK10504 2 TDLPDSVRWQ-LWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 81 GLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMP-SVLAIIRQTFEDQSDQAVA-LGIWGAVastGAAIGPLVGGAL 158
Cdd:PRK10504 81 AIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPvGRLTVMKIVPREQYMAAMTfVTLPGQV---GPLLGPALGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 159 LEHFWWGSVFLINVPVMLLVIPLVIAYIPRRSVVGDgNWTIGQSLILILGVMASVYALKSAFKTNSSVFVTGACFVFGAL 238
Cdd:PRK10504 158 VEYASWHWIFLINIPVGIIGAIATLMLMPNYTMQTR-RFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 239 MLVWFVRKQLHTTTPMLDLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPL 318
Cdd:PRK10504 237 ALLLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 319 AGVILKAIGLRWV-ASCSLLVSAVSLVGLAQIHLGSGGVAVIVMLVaLGLSLSIGLTASSVAIMNSIPMEKAGSAGALEA 397
Cdd:PRK10504 317 VVQVVNRFGYRRVlVATTLGLALVSLLFMLVALLGWYYLLPFVLFL-QGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLS 395
|
410
....*....|....*...
gi 2731878392 398 TSYDLGTGLGITVFGILL 415
Cdd:PRK10504 396 MIMQLSMSIGVTIAGLLL 413
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
10-418 |
3.63e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 83.01 E-value: 3.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 10 LVLMSVILAFMPIVLDytILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGS 89
Cdd:cd17320 1 LLLLALLVALGPLAID--MYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 90 VLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQsDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFL 169
Cdd:cd17320 79 LLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGA-ELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 170 INVPVMLLVIPLVIAYIPRRSVVGdgnwTIGQSLILILGVMASVyaLKSAFktnssvfvtgacFVFGALMLvwfvrkqlh 249
Cdd:cd17320 158 FLALLGLLLLLLVLLFLPETLPEE----KRKPLLSSLLRAYKRV--LKNRR------------FLGYALAL--------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 250 tttpmldlslfsipAVSTGIVMALVTMGALAGFELLLAQELQFvmertpleaGIFMMPLMIAAAIGGPLAGVILKAIGLR 329
Cdd:cd17320 211 --------------GLSFAGLFAYLAAAPFIYIEQLGLSPAQF---------GLLFALNAIALILGSLLNGRLVRRFGPR 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 330 WVASCSLLVSAVSLVGLAQIHLGSGGVAVIVMLVALGLSLSIGLTassVAIMNSIPMEK----AGSAGALEATSYDLGTG 405
Cdd:cd17320 268 RLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLI---FPNATSLALEPfphvAGTASALLGFLQFLIGA 344
|
410
....*....|...
gi 2731878392 406 LGITVFGILLVST 418
Cdd:cd17320 345 LAGALVGLLPNGT 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
9-415 |
3.70e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 76.84 E-value: 3.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 9 WLVLMSVILAFMPIvldyTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAG 88
Cdd:cd17474 2 YAVFFATLLAVLGV----SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 89 SVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQsDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVF 168
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGG-ERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 169 LINVPVMLLVIPLVIAYIPRRSVVGDGNWTIGQSLILILGVMASVyalksafktnsSVFVTGACFVFGalmlvwfvrkql 248
Cdd:cd17474 157 LLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLL-----------TFLVSAFLYFFL------------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 249 htttpmldlsLFSIpavstgivmalvtmgaLAGFELLLAQELQFvmerTPLEAGIFMMPLMIAAAIGGPLAGVIL-KAIG 327
Cdd:cd17474 214 ----------YFAF----------------LTYLPFLLELLYGI----SPIIIGLLFAGWSVLLALGSLFVGRLLkKRFG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 328 LRWVASCSLLVSAVSLVGLAQIHlgsGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLG 407
Cdd:cd17474 264 ARRILVIGLLLYALSLLLLGFVP---SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
....*...
gi 2731878392 408 ITVFGILL 415
Cdd:cd17474 341 PLLFGLLL 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
42-186 |
5.49e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.22 E-value: 5.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 42 ATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLA 121
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2731878392 122 IIRQTFeDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYI 186
Cdd:cd17325 312 LLADIV-PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
49-415 |
2.44e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 65.26 E-value: 2.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 49 WIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFe 128
Cdd:cd17324 38 LLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 129 DQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYIPRRSVVGDGNWTIGQSLILILG 208
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 209 VmasvyalksafktnssvfvtgacfvfgalmlvwfvrkqlhtttpmldlslfsiPAVSTGIVMALVTMGALAGFELLLAQ 288
Cdd:cd17324 197 N-----------------------------------------------------PRLRLAYLITFLLFGGFFALYTYLAP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 289 ELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVILKAIGLRWVASCSLLVSAVSLVGLAqihLGSGGVAVIVMLVALGLS 368
Cdd:cd17324 224 FLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL---LGPSPLLLLVGLVLWGLG 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2731878392 369 LSIGLTASSVAIMNSIPmEKAGSAGALEATSYDLGTGLGITVFGILL 415
Cdd:cd17324 301 FFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVL 346
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
42-403 |
2.63e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 65.29 E-value: 2.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 42 ATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLA 121
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 122 IIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEhFWWGSVFLINVpVMLLVIPLVIAYIPRRSVVGDGNwtigq 201
Cdd:cd17473 112 LIGDYFEGEE-RAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPARKSKSA----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 202 slililgvmASVYALKSAFKTNSSVFVtgACFVFGALMLVWFVrkqLHTTTPMLDLSLFSIPAVSTGIVMALVTmgalag 281
Cdd:cd17473 184 ---------ASPGAATAAALPWKRVLP--IYFLAFLAMLLFYV---IPIQLPFLLQERGGGSAALIGLALAIAS------ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 282 felllaqelqfvmertpleagifmmplmIAAAIGGPLAGVILKAIGLRWVASCSLLVSAVSLVGLAqihLGSGGVAVIVM 361
Cdd:cd17473 244 ----------------------------LAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLA---LASGLWVVLLG 292
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2731878392 362 LVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLG 403
Cdd:cd17473 293 AILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
66-187 |
3.12e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 61.13 E-value: 3.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQsDQAVALGIWGAVAS 145
Cdd:TIGR00880 19 GLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE-ERGVALGLMSAGIA 97
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2731878392 146 TGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYIP 187
Cdd:TIGR00880 98 LGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
8-188 |
6.99e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 63.74 E-value: 6.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 8 RWLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCA 87
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 88 GSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFeDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSV 167
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF-PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA 159
|
170 180
....*....|....*....|.
gi 2731878392 168 FLINVPVMLLVIPLVIAYIPR 188
Cdd:cd17319 160 FIIEGLLGLLLAVLWWFYLRQ 180
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-414 |
7.21e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.77 E-value: 7.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 28 ILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAF 107
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 108 MAFGGAMVMPSVLAIIrQTFEDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVpVMLLVIPLVIAYIP 187
Cdd:cd17489 94 HGIGWGAFTTAAATLV-ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAA-VLALLALLLVFLVK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 188 RRSVVGDgnwtigqslililgvmasvyALKSAFKTNSSVFVTGACFVFGALMLvwfvrkqlhtttpmldlslfsipaVST 267
Cdd:cd17489 172 DPPPVAA--------------------EEAEAGTRAFRRLVEKKVLPPALILF------------------------LAS 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 268 GIVMALVTMGALAGFELLLAQelqfvmertpleAGIFMMPLMIAAAIGGPLAGVILKAIGLRWVASCSLLVSAVSLVGLA 347
Cdd:cd17489 208 IAYGAISTFLPLYAAERGISN------------AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2731878392 348 QIHlgsGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLGITVFGIL 414
Cdd:cd17489 276 FAG---SPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-189 |
1.39e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.97 E-value: 1.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 6 SNRWLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIF 85
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 86 CAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQsdQAVALGIWGAVASTGAAIGPLVGGALLEHFWWG 165
Cdd:COG2807 94 AAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR--VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171
|
170 180
....*....|....*....|....
gi 2731878392 166 SVFLINVPVMLLVIPLVIAYIPRR 189
Cdd:COG2807 172 GALAVWALLALLALLLWLPLLRRR 195
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
65-187 |
2.25e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 62.21 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 65 MGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQsDQAVALGIWGAVA 144
Cdd:cd17323 54 WAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPE-ERGKAMGVYSLGP 132
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2731878392 145 STGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYIP 187
Cdd:cd17323 133 LLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-419 |
2.66e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.06 E-value: 2.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 24 LDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIG 103
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 104 ARAFMAFGGAMVMPSVLAIIRQTFeDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVI 183
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLF-PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 184 AYIPRRSVVGDGNWTigqslililgvmasvyalksafktnssvfvtgacfvfgalmlvwfVRKQLHTTTPMLDLSLFSIP 263
Cdd:cd06174 169 LLLVVPDPPESARAK---------------------------------------------NEEASSKSVLKLLKRVLKNP 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 264 AVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVIL-KAIGLRWVASCSLLVSAVS 342
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSdRLIGRKPLLLIGLLLMALG 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2731878392 343 LVGLAqihLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLGITVFGILLVSTY 419
Cdd:cd06174 284 LALLL---LAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-414 |
1.67e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.48 E-value: 1.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 1 MSNGNSNRWLVLMSVILAFMPIVLDytILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLA 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATA--LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 81 GLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQAVALGiwGAVASTGAAIGPLVGGALLe 160
Cdd:COG0738 79 GLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLL--HAFFSLGALLGPLLGGLLI- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 161 hfwwgsvfLINVPVMLLVIPLVIAyiprrsvvgdgnwtigqSLILILGVMASVYALKSAFKTNSSVFVTGACFvfgalml 240
Cdd:COG0738 156 --------LLGLSLSWHLPYLILA-----------------VLLLLLALLFLRSKLPEIEEEEEEAAGSAASL------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 241 vwfvrkqlhtttpmldLSLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAG 320
Cdd:COG0738 204 ----------------KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 321 VILKAIGLRWVASCSLLVSAVSLVGLAqihLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSY 400
Cdd:COG0738 268 FLLKRFGPVRLLRLSALLAAVGLLLAL---LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI 344
|
410
....*....|....
gi 2731878392 401 dLGTGLGITVFGIL 414
Cdd:COG0738 345 -VGGAIGPPLIGFL 357
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
15-184 |
1.94e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.14 E-value: 1.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 15 VILAFMPIVL---DYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVL 91
Cdd:cd17365 1 LALCFLIIVLdgfDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 92 AAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQtFEDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLIN 171
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSE-YAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLG 159
|
170
....*....|...
gi 2731878392 172 VPVMLLVIPLVIA 184
Cdd:cd17365 160 GVPPLILLPLLRG 172
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
66-414 |
3.95e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 58.44 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQAVALGIWGAVAS 145
Cdd:cd17355 59 GRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGG 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 146 TGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYIPRRSvvgdgnWTIGQSLILILGVMASVYALKSAFKTNSS 225
Cdd:cd17355 139 LGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRP------ADLALRAYDDASPASPGSTLKEALRSASF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 226 VFVTGACFVFGALMlvwfvrkqlhtttpmldlslfsipavsTGIVMALVTMGALAGFelllaqelqfvmerTPLEAGIFM 305
Cdd:cd17355 213 WLLALAFFLCGFAV---------------------------VGLIVHLVPYLADRGI--------------SPAAAAVAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 306 MPLMIAAAIGGPLAGVILKAIGLRWVASCSLLVSAVSLVGLAQIHLGSGGVAVIVMLVALGLSLSIGLTASSVAIMnsIP 385
Cdd:cd17355 252 ALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARY--FG 329
|
330 340
....*....|....*....|....*....
gi 2731878392 386 MEKAGSAGALEATSYDLGTGLGITVFGIL 414
Cdd:cd17355 330 ARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
2-350 |
7.08e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 57.75 E-value: 7.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 2 SNGNSNRWLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAG 81
Cdd:TIGR00895 9 QPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 82 LGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEH 161
Cdd:TIGR00895 89 ILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRF-RGTAVGLMFCGYPIGAAVGGFLAGWLIPV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 162 FWWGSVFLINVPVMLLVIPLVIAYIPRRSVVGDGNWTIGQSLILILGVMASVYALKSAFKTNSSvFVTGACFVFGALMlv 241
Cdd:TIGR00895 168 FGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKS-TQGTKRSVFKALF-- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 242 wfvRKQLHTTTPMLDLSLFsipavstgivMALVTMGALAGFELLLAQELQFVMErtplEAGIFMMPLMIAAAIGGPLAGV 321
Cdd:TIGR00895 245 ---QGKTARITVLLWLLYF----------MLLVGVYFLTNWLPKLMVELGFSLS----LAATGGALFNFGGVIGSIIFGW 307
|
330 340
....*....|....*....|....*....
gi 2731878392 322 ILKAIGLRWVASCSLLVSAVSLVGLAQIH 350
Cdd:TIGR00895 308 LADRLGPRVTALLLLLGAVFAVLVGSTLF 336
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
66-184 |
2.01e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 56.44 E-value: 2.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQAVALGIWGAVAS 145
Cdd:PRK11043 62 GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVAL 141
|
90 100 110
....*....|....*....|....*....|....*....
gi 2731878392 146 TgAAIGPLVGGALLEHFWWGSVFLInvpvmLLVIPLVIA 184
Cdd:PRK11043 142 S-PALAPLLGAWLLNHFGWQAIFAT-----LFAITLLLI 174
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
6-184 |
5.00e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.88 E-value: 5.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 6 SNRWLVLMsVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGT-LADRVGHRRMLLAGLGI 84
Cdd:cd17474 196 RGRGLLTF-LVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 85 FCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEHFWW 164
Cdd:cd17474 275 YALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEE-RGTASSLYNFVRFLGQAVGPLLFGLLLEIFGL 353
|
170 180
....*....|....*....|
gi 2731878392 165 GSVFLINVPVMLLVIPLVIA 184
Cdd:cd17474 354 SAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
53-187 |
8.46e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.14 E-value: 8.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 53 IYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMafGGAMVMPSVLAIIRQTFEDQsD 132
Cdd:cd17472 40 IYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVMALLADLTREE-N 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2731878392 133 QAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYIP 187
Cdd:cd17472 117 RTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVP 171
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
28-344 |
1.29e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 53.71 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 28 ILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAF 107
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 108 MAFGGAMVMPSVLAIIRQTFEdqSDQAVALGIWGAVASTGAAIGPLVGGALLEHFW---WGSVFLINVPVMLLVIPLVIA 184
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAG--GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGglgLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 185 YIPRRSVVGDGNWTIGQ-------SLILILGVMASVYALKSAFKTNSSVFVT--GACFVFGALMLVWFV----------- 244
Cdd:cd17478 172 LKKPEAKKAAAKSSARStlkgvwrALLLLLIIVFLRSWVLSSLTTFLPFYLVqrGYSLVFAGLLLSLFLfagaigtligg 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 245 -------RKQ-----LHTTTPMLDLSLFSiPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAA 312
Cdd:cd17478 252 plsdrfgRRRviiasLLLAAPFLLLFLLT-PGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLG 330
|
330 340 350
....*....|....*....|....*....|..
gi 2731878392 313 AIGGPLAGVILKAIGLRWVASCSLLVSAVSLV 344
Cdd:cd17478 331 GIGAPVLGALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
57-186 |
1.32e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 50.34 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 57 LMASLLIPM-GTLADRVGHRRMLL-AGLGIFCAGSvLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQA 134
Cdd:cd17391 47 LVSAIFSPIwGRLADRYGRKPMLLrASLGMAIVIG-LMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWA 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2731878392 135 VALGIWGAVAstGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYI 186
Cdd:cd17391 126 LGTLSTGVVA--GTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFV 175
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
66-160 |
1.75e-06 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 50.00 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQAVALGIWGAVAS 145
Cdd:cd17383 51 GTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFTEEAERSKALGIALAFIS 130
|
90
....*....|....*
gi 2731878392 146 TGAAIGPLVGGALLE 160
Cdd:cd17383 131 FGCLVAPPFGGILYE 145
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
15-170 |
1.91e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 49.86 E-value: 1.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 15 VILAFMPIVLDY---TILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGL---GIFCAG 88
Cdd:cd17380 1 VILLFLATCICYadrVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAValwSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 89 SVLAAfSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFeDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVF 168
Cdd:cd17380 81 TPLLA-YSSLPLLILSRILLGLGEGVHFPSMTSLFSRWV-PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVF 158
|
..
gi 2731878392 169 LI 170
Cdd:cd17380 159 YF 160
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
66-185 |
2.48e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.51 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEdQSDQAVALGIWGAVAS 145
Cdd:cd17489 248 GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP-PHRRGAANGTFFIFFD 326
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2731878392 146 TGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAY 185
Cdd:cd17489 327 LGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
29-414 |
2.58e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.53 E-value: 2.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 29 LHVAVPSLTLALQATGTEILW---IIDIYPLLMASLLIPMGTLADRVG-HRRMLLAGLGIFCAGSVLAAFSPNVGSLIGA 104
Cdd:cd17490 12 QYVYVPFLSPYAESLGASLSMigiILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 105 RAFMAFGGAM-VMPSVLAIirqTFEDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLinvpvmllviplvi 183
Cdd:cd17490 92 RFLSGIAAATwVSFTVLYA---SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFL-------------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 184 ayiprrsvvgdgnwtigqsliliLGVMASVYALKSAFKTNSSVFVTGACFVFGALMLVWFVRKqlhtttpmlDLSLFSIP 263
Cdd:cd17490 155 -----------------------LAALAGVLGFILSLFIKEERREKKPVLTELKELLSVLKDK---------KLLFFSLL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 264 AvstgIVMALVTMGALAGFELLLAQELQfvmeRTPLEAGIFMMPLMIAAAIGGPLAG-VILKAIGLRWVASCSLLVSAVS 342
Cdd:cd17490 203 A----ILQQMITFSTTFGFTPLIAKQLG----ASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAY 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2731878392 343 LVGLAQIhlgSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLGITVFGIL 414
Cdd:cd17490 275 CFLIPFA---PNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGII 343
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
65-177 |
1.06e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.64 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 65 MGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQsDQAVALGIWGAVA 144
Cdd:cd17391 260 LGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKE-VAGRIFGYNQSFQ 338
|
90 100 110
....*....|....*....|....*....|...
gi 2731878392 145 STGAAIGPLVGGALLEHFWWGSVFLINVPVMLL 177
Cdd:cd17391 339 YLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLL 371
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
66-189 |
1.12e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.61 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDqSDQAVALGIWGAVAS 145
Cdd:cd17329 56 GRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTP-ENRTRAFSLLYWAIN 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2731878392 146 TGAAIGPLVGGALLEHFwWGSVFLINVPVMLLVIPLVIAYIPRR 189
Cdd:cd17329 135 LGVAIGPLLGGLLLLYS-FRLLFLAAAVLFLLAALVLLFLLPET 177
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-189 |
1.63e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 9 WLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRR--MLLAGLGIFC 86
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 87 AGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGS 166
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA-RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|...
gi 2731878392 167 VFLINVPVMLLVIPLVIAYIPRR 189
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRET 361
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
227-415 |
1.94e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 227 FVTGACFVFGALMLVWFVRKQLHTTTPMLDL-----SLFSIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEA 301
Cdd:COG2211 187 LIFAVLGLLAFLLTFFGTKERPVPEEEKVSLkeslkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALV 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 302 GIFMMPLMIAAAIGGPLAGVILKAIGLRWVASCSLLVSAVSLVGLAQIHLGSGGVAVIVMLVAlGLSLSIGLTASSVAIM 381
Cdd:COG2211 267 GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALA-GIGLGAILVLPWAMLA 345
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2731878392 382 NSIPMEKAGSAGALEATSY-------DLGTGLGITVFGILL 415
Cdd:COG2211 346 DVVDYDEWKTGRRREGLYFgiftfaiKLGQALAGALAGLLL 386
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
40-188 |
2.43e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.42 E-value: 2.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 40 LQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSV 119
Cdd:cd17330 29 LGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQ 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2731878392 120 LAIIRQTfeDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYIPR 188
Cdd:cd17330 109 AYIADIT--DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPP 175
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
26-183 |
2.73e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 2.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 26 YTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLI---PMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLI 102
Cdd:cd17370 212 FALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALaayPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 103 GARAFMAFGGAM---VMPSVLAiirqTFEDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVI 179
Cdd:cd17370 292 LGFILWGLYMGAqesIERAAVA----DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIAL 367
|
....
gi 2731878392 180 PLVI 183
Cdd:cd17370 368 LLLL 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-178 |
3.09e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.11 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 8 RWLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCA 87
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 88 GSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFeDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSV 167
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWF-SKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAA 159
|
170
....*....|.
gi 2731878392 168 FLINVPVMLLV 178
Cdd:cd17312 160 FLVPGIVGLVV 170
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
5-162 |
1.11e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 5 NSNRWLVLMSVILAFMPIVLDYTILhvaVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGI 84
Cdd:COG2211 227 NRPFLLLLLAYLLFFLALALVAALL---LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 85 FCAGSVLAAFSP--NVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQ------AVALGIWGAVASTGAAIGPLVGG 156
Cdd:COG2211 304 AALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrreGLYFGIFTFAIKLGQALAGALAG 383
|
....*.
gi 2731878392 157 ALLEHF 162
Cdd:COG2211 384 LLLALF 389
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
63-284 |
1.39e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.15 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 63 IPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSdQAVALGIWGA 142
Cdd:cd17328 52 PIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK-RTRALGVFYF 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 143 VASTGAAIGPLVGGALLEHFW-WGSVFLINVPVMLLVIPLV--IAYIPRRSVVGDGNwtigqslILILGVMASVYALKSA 219
Cdd:cd17328 131 AIPLGSGLGYVVGGLVAQATGgWRWAFRVTGVLGVLLAILLllFVREPPRGAAEGGV-------MAKSTATSFLADLKAL 203
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2731878392 220 FKTNSSVFVT--GACFVFGALMLVWFVRKQLHTTTPMLDLSLFSIPAVSTGIVMALVTMGALAGFEL 284
Cdd:cd17328 204 AKNPSFILSTlgFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGIL 270
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
31-178 |
1.85e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.90 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 31 VAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAF 110
Cdd:TIGR00881 16 LAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGI 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2731878392 111 GGAMVMPSVLAIIRQTFEdQSDQAVALGIWGAVASTGAAIGP-LVGGALLEHFWWGSVFLINVPVMLLV 178
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFS-RSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAIIV 163
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
66-183 |
2.29e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQAVALGIwgAVAS 145
Cdd:cd17324 255 GRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYL--AAYN 332
|
90 100 110
....*....|....*....|....*....|....*...
gi 2731878392 146 TGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVI 183
Cdd:cd17324 333 LGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
40-186 |
3.70e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.92 E-value: 3.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 40 LQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMA-FGGAMVMPS 118
Cdd:cd17352 33 FGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGgLGLGLIYSP 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2731878392 119 VLAIIRQTFEDQsdQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYI 186
Cdd:cd17352 113 AIVIVGQYFEKK--RGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR 178
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
57-169 |
4.05e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.59 E-value: 4.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 57 LMASLLIPMG-------TLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAF--MAFGGAMVMpsVLAIIRQTF 127
Cdd:PRK11652 48 VMAAYLLTYGlsqlfygPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIqgLGTGVGGVM--ARTLPRDLY 125
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2731878392 128 E-DQSDQAVALGIWGAVAStgAAIGPLVGGALLEHFWWGSVFL 169
Cdd:PRK11652 126 EgTQLRHANSLLNMGILVS--PLLAPLIGGLLTTLFGWRACYL 166
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
27-415 |
4.94e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.60 E-value: 4.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 27 TILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGS-----L 101
Cdd:cd06173 16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlslwlL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 102 IGARAFMAFGGAMVMPSVLAII-RQTFEDQSDQAVALGiwGAVASTGAAIGPLVGGALLEHFWWGSVFLINVpVMLLVIP 180
Cdd:cd06173 96 LVLAFLLGIASAFFGPARQALLpELVPKEQLVRANALN--SLATQLARIIGPALGGLLVALLGPGGAFAINA-LSFLLSA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 181 LVIAYIPRRSVVGDGNWTIGQSLILILGVmasvyalksafktnssvfvtgacfvfgalmlvwfvrkqlhtttpmldLSLF 260
Cdd:cd06173 173 LLLLFIRRPPPAAPGESSSLLLRDLREGL-----------------------------------------------RYLR 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 261 SIPAVSTGIVMALVTMGALAGFELLLAQELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVILKAIGLRWVASCSLLVSA 340
Cdd:cd06173 206 RSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2731878392 341 VSLVGLAqihLGSGGVAVIVMLVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLGITVFGILL 415
Cdd:cd06173 286 LALLVLG---LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA 357
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
61-343 |
6.20e-04 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 42.43 E-value: 6.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 61 LLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVG-----SLIGARAFMAFGGAMVMPSVLAII-RQTFEDQSDQA 134
Cdd:pfam05977 61 LSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGllspwLLLGLTFLGGIGTALMDPAWQASVpELVPRRDLPAA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 135 VALGIWGAvaSTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYipRRSVVGDG--NWTIGQSLILILGVMAS 212
Cdd:pfam05977 141 VALNSVGY--NIARSVGPALGGVLLAAFGPAFTFALNALSYFAVIAALWRW--KRAAPASPlpRERIFGAVRAGLRFTAM 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 213 VYALKSAFkTNSSVFVTGACFVFGALMLVwfVRKQLHTTtpmldlslfsipAVSTGIVMALVTMGALAGFELLLAQELQF 292
Cdd:pfam05977 217 SRELRSVL-VRAFAFGLSASAVWALLPLV--ARDLLDGD------------AIFYGILLGAVGVGAILGALSLPRLRERL 281
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2731878392 293 VMERTPLEAGIFMMPLMIAAAIGGPLAG--VILKAIGLRWVASCSLLVSAVSL 343
Cdd:pfam05977 282 GSDRLVLLASVVTALVLLSLALAPNLWLaiPVLLLGGAAWITALTTLNVAVQL 334
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
31-168 |
7.31e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 41.93 E-value: 7.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 31 VAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAF 110
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2731878392 111 GGAMVMPSVLAIIRQTFEDQSdQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVF 168
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRR-RAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
66-187 |
8.99e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.44 E-value: 8.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMvmPSVL--AIIRQTFeDQSDQAVALGIWGAV 143
Cdd:PRK11102 47 GPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA--ASVVinALMRDMF-PKEEFSRMMSFVTLV 123
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2731878392 144 ASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYIP 187
Cdd:PRK11102 124 MTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
11-183 |
1.03e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.54 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 11 VLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSV 90
Cdd:cd17333 201 IILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 91 LAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQAValGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLI 170
Cdd:cd17333 281 ILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGT--SVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLL 358
|
170
....*....|...
gi 2731878392 171 NVPVMLLVIPLVI 183
Cdd:cd17333 359 ITILYAIIFVLAL 371
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
66-187 |
1.36e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.10 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSdQAVALGIWGAVAS 145
Cdd:PRK11551 71 GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRL-RGTAVSLMYCGVP 149
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2731878392 146 TGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYIP 187
Cdd:PRK11551 150 FGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLP 191
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-190 |
2.13e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.61 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 10 LVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGS 89
Cdd:COG0738 211 RLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 90 VLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQAVALGIwgAVASTGAAIGPLVGGALLEHFWWGSVFL 169
Cdd:COG0738 291 LLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL--IMGIVGGAIGPPLIGFLADAFGLRAAFL 368
|
170 180
....*....|....*....|.
gi 2731878392 170 INVPVMLLVIPLVIAYIPRRS 190
Cdd:COG0738 369 VPLVCYLLILLLALALKRKRR 389
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
56-179 |
2.18e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.28 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 56 LLMASLLIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFeDQSDQAV 135
Cdd:cd17331 255 LGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAV-PPEDTGT 333
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2731878392 136 ALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVI 179
Cdd:cd17331 334 ALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLT 377
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
66-186 |
2.24e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 40.29 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 66 GTLADRVGHRRMLLA---GLGIFCagsVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSdqAVALGIWGA 142
Cdd:PRK09874 75 GGLADRKGRKIMLLRsalGMGIVM---VLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKS--GWALGTLST 149
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2731878392 143 VASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYI 186
Cdd:PRK09874 150 GGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCI 193
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
9-185 |
2.30e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 9 WLVLMSVILAFMPIVLDYTILHVAVPSLTLALQATGteilWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFCAG 88
Cdd:cd17329 204 LFLLASFLISLIYFQLESTLPVYVVEILGLGESLLG----LLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 89 SVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQtFEDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVF 168
Cdd:cd17329 280 FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA-LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
|
170
....*....|....*..
gi 2731878392 169 LINVPVMLLVIPLVIAY 185
Cdd:cd17329 359 LILAALGLIAAALLLGL 375
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
7-102 |
3.31e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.90 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 7 NRWLVLMSVILAFMPIVLDYTiLHVAVPSLTLALQATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGLGIFC 86
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYA-WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90
....*....|....*.
gi 2731878392 87 AGSVLAAFSPNVGSLI 102
Cdd:cd17353 80 LGFILSAFAISLPLLF 95
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
17-165 |
4.46e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 39.52 E-value: 4.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 17 LAFMPIVLDYTILHVAVPSLT--LALQATGTEILWIIdIYPLLMASLLIpMGTLADRVGHRRMLLAGLGIFCAGSVLAAF 94
Cdd:cd17438 6 LALMADGVEVFVVGFVLPSAEkdMCLSSSNKGMLGLI-VYLGMMAGAFI-WGGLADKLGRKRCLIISLAINASFAFLSSF 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2731878392 95 SPNVGSLIGARAFMAFGGAMVMPSVLAIIRQtFEDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWG 165
Cdd:cd17438 84 VQGYGAFLFCRLISGFGIGGSLPIVFAYFSE-FLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWG 153
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
10-490 |
5.49e-03 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 39.21 E-value: 5.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 10 LVLMSVILAFMPIVLDYTILHVAVPSLTLALQATgtEILWIIDIYPLLMASLL-IPMGTLADRVGHRRMLLAGLGIFCAG 88
Cdd:cd17322 3 ILFFSLFLCGFAIGLDGQIRYSYQAYATSSFSKH--SLLSTINVVNNIVSAVSqPPYAKLSDVFGRLELFLVSLLLYVVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 89 SVLAAFSPNVGSLIGARAFMAFGGAMVMpsvlaIIRQTFEDQSDQAVALGIWGAVASTGAAIGPLVGGALLEHF-----W 163
Cdd:cd17322 81 TIIMAASTNVQTYAAGSVFYNAGYTGLN-----LLLTLILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAAlpnsnW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 164 -WG-SVFLINVPVMLLVIPLVIAYIPRRSvVGDGNW----------------------------------TIGQSLILIL 207
Cdd:cd17322 156 rWGyGMWAIILPLSSLPLVLCLLYMQRKA-RKDGEIkelknqeteeqtgglsqnlvklfwkldifgvillTAGLGLILVP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 208 GVMASvyALKSAFKTNSSVFVTGACFVFGALMLVWFVRKQLHtttPMLDLSLFSIPAVSTGIVMALVTMGALAGFELLLA 287
Cdd:cd17322 235 LTLAG--GAKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKY---PFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLY 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 288 QELQFVMERTPLEAGIFMMPLMIAAAIGGPLAGVILKAIG-LRW--VASCSLLVSAVSLVglaqIHLGSGG---VAVIVM 361
Cdd:cd17322 310 TVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRrYKVlvIIGVPLYIVGMGLL----IRYRGGSgshGGIIGA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 362 LVALGLSLSIGLTASSVAIMNSIPMEKAGSAGALEATSYDLGTGLGITVFGILLVSTYEKsiQLPDGIPSAMAETAVRSI 441
Cdd:cd17322 386 LILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTLPK--KLLKNLPDSLKATAAYIF 463
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 2731878392 442 GETMIAAKTlggIQGQQLAAAGQKAFsaSHSMVLLTAAALVGALSLLVW 490
Cdd:cd17322 464 PSTFVILSY---PWGTPERDAIIESY--RYVQRILLIVALVFSAPMFAL 507
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
66-121 |
7.23e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 38.79 E-value: 7.23e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2731878392 66 GTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFG---GAMVMPSVLA 121
Cdd:cd17360 56 GWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGvgiASMTVPLYIA 114
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| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
42-188 |
7.49e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 38.74 E-value: 7.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 42 ATGTEILWIIDIYPLLMASLLIPMGTLADRVGHRRMLLAGlgIFCAGSV-----LAAFSPNVGSLIG----ARAFMAFGG 112
Cdd:cd17385 31 VSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAG--MFVSGGCtilfgFLDRVPDGTVFIAlcflVRIVEAVGF 108
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90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2731878392 113 AMVMPSVLAIIRQTFEDqsDQAVALGIWGAVASTGAAIGPLVGGALLEHFWWGSVFLINVPVMLLVIPLVIAYIPR 188
Cdd:cd17385 109 AAFITASFAIIAKEFPN--NIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFILPR 182
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|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
63-184 |
7.58e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 38.70 E-value: 7.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 63 IPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQSDQAVALGIWGA 142
Cdd:COG2807 268 LLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQS 347
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2731878392 143 VASTGAAIGPLVGGALleHFWWGSVFLINVPVMLLVIPLVIA 184
Cdd:COG2807 348 VGYLLAALGPLLVGAL--HDATGSWTAALLLLAALAVLMLVA 387
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|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
62-170 |
9.52e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 38.37 E-value: 9.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2731878392 62 LIPMGTLADRVGHRRMLLAGLGIFCAGSVLAAFSPNVGSLIGARAFMAFGGAMVMPSVLAIIRQTFEDQsDQAVALGIWG 141
Cdd:cd17475 48 MLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPR-ERGLAMGIRQ 126
|
90 100
....*....|....*....|....*....
gi 2731878392 142 AVASTGAAIGPLVGGALLEHFWWGSVFLI 170
Cdd:cd17475 127 TGVPLGGALAAALLPPLALHYGWRAAFVV 155
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