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Conserved domains on  [gi|2734142201|ref|WP_346391509|]
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ABC-three component system protein, partial [Streptococcus pyogenes]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTD11 pfam20277
C-terminal domain 11 of the ABC-three component (ABC-3C) systems; C-terminal domains (CTDs) of ...
 125-261 4.84e-50

C-terminal domain 11 of the ABC-three component (ABC-3C) systems; C-terminal domains (CTDs) of ABC-3C systems, contain distinct patterns of charged and polar residues and are not yet unifiable with known domains. These domains are found at the C-terminus of the effector component of the systems, which are upstream of the Middle Component and ABC ATPase components on the genome. Due to the typically large size of these CTDs relative to the actual effector and MC domains, the CTDs are predicted to serve as the platform on which the remaining two components assemble. Therewith, conformational changes transmitted by the ABC ATPase-mediated detection of invasive elements like DNA viruses would result in an unfurling and activation of the CTD-associated effector.


:

Pssm-ID: 466427  Cd Length: 140  Bit Score: 160.94  E-value: 4.84e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734142201 125 SQQAISDMKLDSGIVSVLTSLNKLKCDEY--DISYDSKQLTDKISPENNRTLYQLVKNPVIDNYLTIQKIIVNLDKQGKI 202
Cdd:pfam20277   1 ARQLISDSKLEEEITSVIEKLSELDVTEDisDLNYDPVTVEEKIDPEINFLLKRRVKNDVTDYYNFIQNQFSELDGEGKL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734142201 203 DYEEIQYQTRSMYKKLKAAKHNNLAIFNTISEKLHKAT-LQDIYFCQTIVSYFIQKCEVL 261
Cdd:pfam20277  81 DFDLIANQIKSMYLKLKDKKLDQQAIFDELADWLSTKTsQQSREACEIIVSYFVQNCEVF 140
 
Name Accession Description Interval E-value
CTD11 pfam20277
C-terminal domain 11 of the ABC-three component (ABC-3C) systems; C-terminal domains (CTDs) of ...
 125-261 4.84e-50

C-terminal domain 11 of the ABC-three component (ABC-3C) systems; C-terminal domains (CTDs) of ABC-3C systems, contain distinct patterns of charged and polar residues and are not yet unifiable with known domains. These domains are found at the C-terminus of the effector component of the systems, which are upstream of the Middle Component and ABC ATPase components on the genome. Due to the typically large size of these CTDs relative to the actual effector and MC domains, the CTDs are predicted to serve as the platform on which the remaining two components assemble. Therewith, conformational changes transmitted by the ABC ATPase-mediated detection of invasive elements like DNA viruses would result in an unfurling and activation of the CTD-associated effector.


Pssm-ID: 466427  Cd Length: 140  Bit Score: 160.94  E-value: 4.84e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734142201 125 SQQAISDMKLDSGIVSVLTSLNKLKCDEY--DISYDSKQLTDKISPENNRTLYQLVKNPVIDNYLTIQKIIVNLDKQGKI 202
Cdd:pfam20277   1 ARQLISDSKLEEEITSVIEKLSELDVTEDisDLNYDPVTVEEKIDPEINFLLKRRVKNDVTDYYNFIQNQFSELDGEGKL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734142201 203 DYEEIQYQTRSMYKKLKAAKHNNLAIFNTISEKLHKAT-LQDIYFCQTIVSYFIQKCEVL 261
Cdd:pfam20277  81 DFDLIANQIKSMYLKLKDKKLDQQAIFDELADWLSTKTsQQSREACEIIVSYFVQNCEVF 140
 
Name Accession Description Interval E-value
CTD11 pfam20277
C-terminal domain 11 of the ABC-three component (ABC-3C) systems; C-terminal domains (CTDs) of ...
 125-261 4.84e-50

C-terminal domain 11 of the ABC-three component (ABC-3C) systems; C-terminal domains (CTDs) of ABC-3C systems, contain distinct patterns of charged and polar residues and are not yet unifiable with known domains. These domains are found at the C-terminus of the effector component of the systems, which are upstream of the Middle Component and ABC ATPase components on the genome. Due to the typically large size of these CTDs relative to the actual effector and MC domains, the CTDs are predicted to serve as the platform on which the remaining two components assemble. Therewith, conformational changes transmitted by the ABC ATPase-mediated detection of invasive elements like DNA viruses would result in an unfurling and activation of the CTD-associated effector.


Pssm-ID: 466427  Cd Length: 140  Bit Score: 160.94  E-value: 4.84e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734142201 125 SQQAISDMKLDSGIVSVLTSLNKLKCDEY--DISYDSKQLTDKISPENNRTLYQLVKNPVIDNYLTIQKIIVNLDKQGKI 202
Cdd:pfam20277   1 ARQLISDSKLEEEITSVIEKLSELDVTEDisDLNYDPVTVEEKIDPEINFLLKRRVKNDVTDYYNFIQNQFSELDGEGKL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734142201 203 DYEEIQYQTRSMYKKLKAAKHNNLAIFNTISEKLHKAT-LQDIYFCQTIVSYFIQKCEVL 261
Cdd:pfam20277  81 DFDLIANQIKSMYLKLKDKKLDQQAIFDELADWLSTKTsQQSREACEIIVSYFVQNCEVF 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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