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Conserved domains on  [gi|2734469700|ref|WP_346658699|]
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MFS transporter, partial [Morganella morganii]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-123 9.42e-53

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17345:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 411  Bit Score: 172.04  E-value: 9.42e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMS 80
Cdd:cd17345   289 WLSDKLFKGRRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFG 368

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2734469700  81 YILGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCILSH 123
Cdd:cd17345   369 YLGGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
 
Name Accession Description Interval E-value
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 1-123 9.42e-53

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 172.04  E-value: 9.42e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMS 80
Cdd:cd17345   289 WLSDKLFKGRRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFG 368

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2734469700  81 YILGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCILSH 123
Cdd:cd17345   369 YLGGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 1-105 6.62e-28

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 105.92  E-value: 6.62e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQ--SQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGF 78
Cdd:TIGR00881 274 WLSDKLFNGRRGPLAVFFMALIIVSLLVYWLnpAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGF 353

                          90       100
                  ....*....|....*....|....*..
gi 2734469700  79 MSYiLGATLGTTLFGFIVDRMGWHGGF 105
Cdd:TIGR00881 354 FAY-LGGILAGLPLGYLADGFGWAGAF 379
glpT PRK11273
glycerol-3-phosphate transporter;
1-141 1.39e-20

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 86.69  E-value: 1.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAA--VVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGF 78
Cdd:PRK11273  311 WMSDKVFRGNRGATGVFFMTLVTIATIVYWLNPAGNPTVDMACmiVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGL 390

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2734469700  79 MSYILGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCILSHFGalelERNRQQALSEEK 141
Cdd:PRK11273  391 FGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIG----EKRHHEELLQKR 449
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-121 2.98e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 65.66  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIvCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMS 80
Cdd:COG2271   238 WLSDRLGRRRKLVLAI-GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG 316

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2734469700  81 YIlGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCIL 121
Cdd:COG2271   317 FL-GGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
MFS_1 pfam07690
Major Facilitator Superfamily;
1-121 2.55e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 37.01  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVpqfLASVQTMEIVPSFAVGSAVGLRGfMS 80
Cdd:pfam07690  54 RLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFP---AALALIADWFPPEERGRALGLVS-AG 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2734469700  81 YILGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCIL 121
Cdd:pfam07690 130 FGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
 
Name Accession Description Interval E-value
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 1-123 9.42e-53

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 172.04  E-value: 9.42e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMS 80
Cdd:cd17345   289 WLSDKLFKGRRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFG 368

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2734469700  81 YILGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCILSH 123
Cdd:cd17345   369 YLGGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 1-105 6.62e-28

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 105.92  E-value: 6.62e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQ--SQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGF 78
Cdd:TIGR00881 274 WLSDKLFNGRRGPLAVFFMALIIVSLLVYWLnpAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGF 353

                          90       100
                  ....*....|....*....|....*..
gi 2734469700  79 MSYiLGATLGTTLFGFIVDRMGWHGGF 105
Cdd:TIGR00881 354 FAY-LGGILAGLPLGYLADGFGWAGAF 379
glpT PRK11273
glycerol-3-phosphate transporter;
1-141 1.39e-20

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 86.69  E-value: 1.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAA--VVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGF 78
Cdd:PRK11273  311 WMSDKVFRGNRGATGVFFMTLVTIATIVYWLNPAGNPTVDMACmiVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGL 390

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2734469700  79 MSYILGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCILSHFGalelERNRQQALSEEK 141
Cdd:PRK11273  391 FGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIG----EKRHHEELLQKR 449
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 1-121 2.08e-15

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 71.54  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQS-QSLAVVTFFAAVVGCLIYVPQ-FLASVQTMEIVPSFAVGSAVGLRGF 78
Cdd:cd17312   241 LLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFpHNKLLSIVLLFLIGFFVGGPInLIGGAAAQDIGRKEAAGTATGFVGL 320

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2734469700  79 MSYIlGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCIL 121
Cdd:cd17312   321 FGYL-GASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLS 362
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-121 2.98e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 65.66  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIvCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMS 80
Cdd:COG2271   238 WLSDRLGRRRKLVLAI-GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG 316

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2734469700  81 YIlGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCIL 121
Cdd:COG2271   317 FL-GGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
1-117 2.40e-12

hexose-6-phosphate:phosphate antiporter;


Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 63.14  E-value: 2.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLfKGRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMS 80
Cdd:PRK09556  316 WLSDLA-NGRRALVACIALALIIFTLGVYQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFA 394

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2734469700  81 YILG--------------ATLGTTLFGFIVDrmGWHGGFYLLLGGIVCCII 117
Cdd:PRK09556  395 YLFGdsfakvglgmiadpTKNGTPIFGYTLT--GWAGTFAALDIAAIGCIC 443
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
 1-109 9.43e-10

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 55.49  E-value: 9.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQSQS----LAVVTFFaaVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLR 76
Cdd:cd17488   241 WGSDKLFKGNRGPMNLIFALGLLVSVGALWLVPVhsywLLATCFF--TIGFFVFGPQMLIGMAAAECSHKDAAGSATGFV 318

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2734469700  77 GFMSYiLGATLGTTLFGFIVDRMGWHGGFYLLL 109
Cdd:cd17488   319 GLFAY-LGAALAGYPLAKVIESWGWSGFFIVIS 350
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-124 2.33e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 45.64  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTL--IFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVqtMEIVPSFAVGSAVGLRGF 78
Cdd:cd17319   237 RLSDRLLRGARRLVIIIGLLLaaVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLP--ADLLPGEAAATAGGLINS 314

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2734469700  79 MSYiLGATLGTTLFGFIVDRMG-WHGGFYLLlggIVCCIIFCILSHF 124
Cdd:cd17319   315 GGN-LGGFVAPLLIGYLVDATGsYTAAFLFL---AAVALLAALLVLL 357
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
1-105 5.87e-06

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 44.70  E-value: 5.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYW----QSQSLAVVTFFAavVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLR 76
Cdd:PRK11663  301 WGSDKLFNGNRGPMNLIFAAGILLSVGSLWlmpfASYVMQAACFFT--IGFFVFGPQMLIGMAAAECSHKEAAGAATGFV 378

                          90       100
                  ....*....|....*....|....*....
gi 2734469700  77 GFMSYiLGATLGTTLFGFIVDRMGWHGGF 105
Cdd:PRK11663  379 GLFAY-LGAALSGYPLAKVLEIWHWTGFF 406
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 1-121 8.51e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.40  E-value: 8.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFfCLIGYWQSQSLAVVTFFAAVVGCLIYVPqflaSVQT--MEIVPSFAVGSAVGLRGF 78
Cdd:cd17474   257 LLKKRFGARRILVIGLLLYALSL-LLLGFVPSLALLLIAIVLFGLGLGLNLP----LLTTlvTELAPEEERGTASSLYNF 331

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2734469700  79 MSYiLGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCIL 121
Cdd:cd17474   332 VRF-LGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-121 9.59e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 9.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLfkGRRmPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGfMS 80
Cdd:cd17325   257 KLSDRI--GRK-PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFN-TA 332

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2734469700  81 YILGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCIL 121
Cdd:cd17325   333 FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-121 1.55e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.63  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVqtMEIVPSFAVGSAVGLrGFMS 80
Cdd:COG2223   263 WLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV--PDIFPTKNAGAVYGL-VGAA 339

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2734469700  81 YILGATLGTTLFGFIVDRMG-WHGGFYLLLGGIVCCIIFCIL 121
Cdd:COG2223   340 GGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLL 381
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-121 5.94e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 5.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLfkGRRmPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGfMS 80
Cdd:COG2814    67 RLADRF--GRR-RVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLG-AG 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2734469700  81 YILGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCIL 121
Cdd:COG2814   143 LGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 1-113 7.30e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.37  E-value: 7.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMP------LAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFlasVQTMEIVPSFAVGSAVG 74
Cdd:cd17475   256 RVSDRVFGGRRRPvlvitaAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYL---TLVAESAGPEQAGTALG 332

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2734469700  75 LRGFMSYIlGATLGTTLFGFIVDRMGWHGGFYLLLGGIV 113
Cdd:cd17475   333 LANTINFI-GIAIGPPLFGLLVDATHSYAPAWLALALLL 370
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-120 1.92e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 37.41  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFkgRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMS 80
Cdd:cd06174   261 LLSDRLI--GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFG 338

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2734469700  81 YiLGATLGTTLFGFIVDRM-GWHGGFYLLLGGIVCCIIFCI 120
Cdd:cd06174   339 F-LGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
1-121 2.55e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 37.01  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKLFKGRRMPLAIVCMTLIFFCLIGYWQSQSLAVVTFFAAVVGCLIYVpqfLASVQTMEIVPSFAVGSAVGLRGfMS 80
Cdd:pfam07690  54 RLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFP---AALALIADWFPPEERGRALGLVS-AG 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2734469700  81 YILGATLGTTLFGFIVDRMGWHGGFYLLLGGIVCCIIFCIL 121
Cdd:pfam07690 130 FGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 1-117 7.65e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 35.63  E-value: 7.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2734469700   1 WLTDKlFKGRRmpLAIVCMTLIFFCLIGYWQSQSLAVVTFF----AAVVGCLIYVPQFLAsvqtMEIVPSFAVGSAVGLR 76
Cdd:cd17503    53 WLADR-FGTRR--LFLTALALFTLGSLLCGLAPNLASLIIFrilqGFGGGVLIPLAQTIL----LRIYPPEKRGAAMGLV 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2734469700  77 GfMSYILGATLGTTLFGFIVDRMGWHGGFYLLLG-GIVCCII 117
Cdd:cd17503   126 G-LVILLAPAIGPTLGGWLTDNLSWRWIFYINLPiGILALLL 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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