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Conserved domains on  [gi|2735215716|ref|WP_346772107|]
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beta-ketoacyl synthase N-terminal-like domain-containing protein [Epilithonimonas pallida]

Protein Classification

beta-ketoacyl-[acyl-carrier-protein] synthase family protein( domain architecture ID 408)

beta-ketoacyl-[acyl-carrier-protein] synthase family protein may catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cond_enzymes super family cl09938
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ...
 3-314 9.24e-58

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.


The actual alignment was detected with superfamily member cd00834:

Pssm-ID: 447866 [Multi-domain]  Cd Length: 406  Bit Score: 191.21  E-value: 9.24e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   3 KEIYITDYNCVTPLGFDVSSNWNALLEGKSGValHKIIENQEPFYASMIDSEKLNEEFNRFFDSAQNNNLSftRLEKMFL 82
Cdd:cd00834     1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGI--RPITRFDASGFPSRIAGEVPDFDPEDYLDRKELRRMD--RFAQFAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  83 LSLKP------LVEKHQISDETAFILSTTKGNI-SLLKNQKTLPEG------------IFLSSLAQKIADFFGFKTKPIV 143
Cdd:cd00834    77 AAAEEaladagLDPEELDPERIGVVIGSGIGGLaTIEEAYRALLEKgprrvspffvpmALPNMAAGQVAIRLGLRGPNYT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 144 VSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDE-ISEFVISGFNSFQAIGTE------ICKPYDKNRDGINIGEAAAAV 216
Cdd:cd00834   157 VSTACASGAHAIGDAARLIRLGRADVVIAGGAEAlITPLTLAGFAALRALSTRnddpekASRPFDKDRDGFVLGEGAGVL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 217 YITgchSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYNDEMEA 296
Cdd:cd00834   237 VLE---SLEHAKARGAKIYAEILGYGASSDAYHITAPDPDGEGAARAMRAALADAGLSPEDIDYINAHGTSTPLNDAAES 313

                         330       340
                  ....*....|....*....|.
gi 2735215716 297 IAFNRM---ELQNVPLNSMKG 314
Cdd:cd00834   314 KAIKRVfgeHAKKVPVSSTKS 334
 
Name Accession Description Interval E-value
KAS_I_II cd00834
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ...
 3-314 9.24e-58

Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.


Pssm-ID: 238430 [Multi-domain]  Cd Length: 406  Bit Score: 191.21  E-value: 9.24e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   3 KEIYITDYNCVTPLGFDVSSNWNALLEGKSGValHKIIENQEPFYASMIDSEKLNEEFNRFFDSAQNNNLSftRLEKMFL 82
Cdd:cd00834     1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGI--RPITRFDASGFPSRIAGEVPDFDPEDYLDRKELRRMD--RFAQFAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  83 LSLKP------LVEKHQISDETAFILSTTKGNI-SLLKNQKTLPEG------------IFLSSLAQKIADFFGFKTKPIV 143
Cdd:cd00834    77 AAAEEaladagLDPEELDPERIGVVIGSGIGGLaTIEEAYRALLEKgprrvspffvpmALPNMAAGQVAIRLGLRGPNYT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 144 VSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDE-ISEFVISGFNSFQAIGTE------ICKPYDKNRDGINIGEAAAAV 216
Cdd:cd00834   157 VSTACASGAHAIGDAARLIRLGRADVVIAGGAEAlITPLTLAGFAALRALSTRnddpekASRPFDKDRDGFVLGEGAGVL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 217 YITgchSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYNDEMEA 296
Cdd:cd00834   237 VLE---SLEHAKARGAKIYAEILGYGASSDAYHITAPDPDGEGAARAMRAALADAGLSPEDIDYINAHGTSTPLNDAAES 313

                         330       340
                  ....*....|....*....|.
gi 2735215716 297 IAFNRM---ELQNVPLNSMKG 314
Cdd:cd00834   314 KAIKRVfgeHAKKVPVSSTKS 334
FabB COG0304
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ...
 3-314 2.12e-52

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440073 [Multi-domain]  Cd Length: 409  Bit Score: 177.21  E-value: 2.12e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   3 KEIYITDYNCVTPLGFDVSSNWNALLEGKSGVAlhKIIENQEPFYASMIDSEKLNEEFNRFFDSAQNNNLSftRLEKMFL 82
Cdd:COG0304     1 RRVVITGLGAVSPLGNGVEEFWEALLAGRSGIR--PITRFDASGLPVRIAGEVKDFDPEEYLDRKELRRMD--RFTQYAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  83 LSLKP------LVEKHQISDETAFILSTTKGNI-SLLKNQKTLPEG------------IFLSSLAQKIADFFGFKTKPIV 143
Cdd:COG0304    77 AAAREaladagLDLDEVDPDRTGVIIGSGIGGLdTLEEAYRALLEKgprrvspffvpmMMPNMAAGHVSIRFGLKGPNYT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 144 VSNACVSGVMAIAVAKNMIRAGKYkDAfVIAG---DEISEFVISGFNSFQAIGT------EICKPYDKNRDGINIGEAAA 214
Cdd:COG0304   157 VSTACASGAHAIGEAYRLIRRGRA-DV-MIAGgaeAAITPLGLAGFDALGALSTrnddpeKASRPFDKDRDGFVLGEGAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 215 AVYITgchSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYNDEM 294
Cdd:COG0304   235 VLVLE---ELEHAKARGAKIYAEVVGYGASSDAYHITAPAPDGEGAARAMRAALKDAGLSPEDIDYINAHGTSTPLGDAA 311

                         330       340
                  ....*....|....*....|...
gi 2735215716 295 EAIAFNR---MELQNVPLNSMKG 314
Cdd:COG0304   312 ETKAIKRvfgDHAYKVPVSSTKS 334
PRK09185 PRK09185
beta-ketoacyl-ACP synthase;
5-314 5.40e-38

beta-ketoacyl-ACP synthase;


Pssm-ID: 236398 [Multi-domain]  Cd Length: 392  Bit Score: 138.82  E-value: 5.40e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   5 IYITDYNCVTPLGFDVSSNWNALLEGKSG--VALHKIIENQEPFYASMIDSE--KLNEEFNRFfDSaQNNNLSFTRLEKm 80
Cdd:PRK09185    4 VYISAFGATSALGRGLDAILAALRAGRASgmRPCDFWLVDLPTWVGEVVGVElpALPAALAAF-DC-RNNRLALLALQQ- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  81 FLLSLKPLVEKHQiSDETAFILSTTKGNIS--------LLKNQKTLPEGIF-----LSSLAQKIADFFGFKTKPIVVSNA 147
Cdd:PRK09185   81 IEPAVEAAIARYG-ADRIGVVLGTSTSGILegelayrrRDPAHGALPADYHyaqqeLGSLADFLRAYLGLSGPAYTISTA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 148 CVSGVMAIAVAKNMIRAGkYKDAFVIAG-DEISEFVISGFNSFQAIGTEICKPYDKNRDGINIGEAAAAVYITGCHSDEG 226
Cdd:PRK09185  160 CSSSAKVFASARRLLEAG-LCDAAIVGGvDSLCRLTLNGFNSLESLSPQPCRPFSANRDGINIGEAAAFFLLEREDDAAV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 227 RIsqnekfsfkiLGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYNDEMEAIAFNRMELQN 306
Cdd:PRK09185  239 AL----------LGVGESSDAHHMSAPHPEGLGAILAMQQALADAGLAPADIGYINLHGTATPLNDAMESRAVAAVFGDG 308


                  ....*...
gi 2735215716 307 VPLNSMKG 314
Cdd:PRK09185  309 VPCSSTKG 316
ketoacyl-synt pfam00109
Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar ...
 3-216 3.45e-09

Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.


Pssm-ID: 425468 [Multi-domain]  Cd Length: 251  Bit Score: 56.49  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   3 KEIYITDYNCVTPLGFDVSSNWNALLEGKSGVA--------------LHKIIENQEPFYASMIDSEklnEEF-NRFFDSA 67
Cdd:pfam00109   1 EPVAIVGMGCRFPGGNDPEEFWENLLEGRDGISeipadrwdpdklydPPSRIAGKIYTKWGGLDDI---FDFdPLFFGIS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  68 QNNNLSFTRLEKMFLLSLKPLVE------KHQISDETAFIL---STTKGNISLLKNQK------TLPEGIFLSSLAQKIA 132
Cdd:pfam00109  78 PREAERMDPQQRLLLEAAWEALEdagitpDSLDGSRTGVFIgsgIGDYAALLLLDEDGgprrgsPFAVGTMPSVIAGRIS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 133 DFFGFKTKPIVVSNACVSGVMAIAVAKNMIRAGKyKDAfVIAG---DEISEFVISGfnsFQAIG----TEICKPYDKNRD 205
Cdd:pfam00109 158 YFLGLRGPSVTVDTACSSSLVAIHAAVQSIRSGE-ADV-ALAGgvnLLLTPLGFAG---FSAAGmlspDGPCKAFDPFAD 232

                         250
                  ....*....|.
gi 2735215716 206 GINIGEAAAAV 216
Cdd:pfam00109 233 GFVRGEGVGAV 243
 
Name Accession Description Interval E-value
KAS_I_II cd00834
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ...
 3-314 9.24e-58

Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.


Pssm-ID: 238430 [Multi-domain]  Cd Length: 406  Bit Score: 191.21  E-value: 9.24e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   3 KEIYITDYNCVTPLGFDVSSNWNALLEGKSGValHKIIENQEPFYASMIDSEKLNEEFNRFFDSAQNNNLSftRLEKMFL 82
Cdd:cd00834     1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGI--RPITRFDASGFPSRIAGEVPDFDPEDYLDRKELRRMD--RFAQFAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  83 LSLKP------LVEKHQISDETAFILSTTKGNI-SLLKNQKTLPEG------------IFLSSLAQKIADFFGFKTKPIV 143
Cdd:cd00834    77 AAAEEaladagLDPEELDPERIGVVIGSGIGGLaTIEEAYRALLEKgprrvspffvpmALPNMAAGQVAIRLGLRGPNYT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 144 VSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDE-ISEFVISGFNSFQAIGTE------ICKPYDKNRDGINIGEAAAAV 216
Cdd:cd00834   157 VSTACASGAHAIGDAARLIRLGRADVVIAGGAEAlITPLTLAGFAALRALSTRnddpekASRPFDKDRDGFVLGEGAGVL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 217 YITgchSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYNDEMEA 296
Cdd:cd00834   237 VLE---SLEHAKARGAKIYAEILGYGASSDAYHITAPDPDGEGAARAMRAALADAGLSPEDIDYINAHGTSTPLNDAAES 313

                         330       340
                  ....*....|....*....|.
gi 2735215716 297 IAFNRM---ELQNVPLNSMKG 314
Cdd:cd00834   314 KAIKRVfgeHAKKVPVSSTKS 334
FabB COG0304
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ...
 3-314 2.12e-52

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440073 [Multi-domain]  Cd Length: 409  Bit Score: 177.21  E-value: 2.12e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   3 KEIYITDYNCVTPLGFDVSSNWNALLEGKSGVAlhKIIENQEPFYASMIDSEKLNEEFNRFFDSAQNNNLSftRLEKMFL 82
Cdd:COG0304     1 RRVVITGLGAVSPLGNGVEEFWEALLAGRSGIR--PITRFDASGLPVRIAGEVKDFDPEEYLDRKELRRMD--RFTQYAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  83 LSLKP------LVEKHQISDETAFILSTTKGNI-SLLKNQKTLPEG------------IFLSSLAQKIADFFGFKTKPIV 143
Cdd:COG0304    77 AAAREaladagLDLDEVDPDRTGVIIGSGIGGLdTLEEAYRALLEKgprrvspffvpmMMPNMAAGHVSIRFGLKGPNYT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 144 VSNACVSGVMAIAVAKNMIRAGKYkDAfVIAG---DEISEFVISGFNSFQAIGT------EICKPYDKNRDGINIGEAAA 214
Cdd:COG0304   157 VSTACASGAHAIGEAYRLIRRGRA-DV-MIAGgaeAAITPLGLAGFDALGALSTrnddpeKASRPFDKDRDGFVLGEGAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 215 AVYITgchSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYNDEM 294
Cdd:COG0304   235 VLVLE---ELEHAKARGAKIYAEVVGYGASSDAYHITAPAPDGEGAARAMRAALKDAGLSPEDIDYINAHGTSTPLGDAA 311

                         330       340
                  ....*....|....*....|...
gi 2735215716 295 EAIAFNR---MELQNVPLNSMKG 314
Cdd:COG0304   312 ETKAIKRvfgDHAYKVPVSSTKS 334
PRK09185 PRK09185
beta-ketoacyl-ACP synthase;
5-314 5.40e-38

beta-ketoacyl-ACP synthase;


Pssm-ID: 236398 [Multi-domain]  Cd Length: 392  Bit Score: 138.82  E-value: 5.40e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   5 IYITDYNCVTPLGFDVSSNWNALLEGKSG--VALHKIIENQEPFYASMIDSE--KLNEEFNRFfDSaQNNNLSFTRLEKm 80
Cdd:PRK09185    4 VYISAFGATSALGRGLDAILAALRAGRASgmRPCDFWLVDLPTWVGEVVGVElpALPAALAAF-DC-RNNRLALLALQQ- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  81 FLLSLKPLVEKHQiSDETAFILSTTKGNIS--------LLKNQKTLPEGIF-----LSSLAQKIADFFGFKTKPIVVSNA 147
Cdd:PRK09185   81 IEPAVEAAIARYG-ADRIGVVLGTSTSGILegelayrrRDPAHGALPADYHyaqqeLGSLADFLRAYLGLSGPAYTISTA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 148 CVSGVMAIAVAKNMIRAGkYKDAFVIAG-DEISEFVISGFNSFQAIGTEICKPYDKNRDGINIGEAAAAVYITGCHSDEG 226
Cdd:PRK09185  160 CSSSAKVFASARRLLEAG-LCDAAIVGGvDSLCRLTLNGFNSLESLSPQPCRPFSANRDGINIGEAAAFFLLEREDDAAV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 227 RIsqnekfsfkiLGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYNDEMEAIAFNRMELQN 306
Cdd:PRK09185  239 AL----------LGVGESSDAHHMSAPHPEGLGAILAMQQALADAGLAPADIGYINLHGTATPLNDAMESRAVAAVFGDG 308


                  ....*...
gi 2735215716 307 VPLNSMKG 314
Cdd:PRK09185  309 VPCSSTKG 316
PRK07314 PRK07314
beta-ketoacyl-ACP synthase II;
2-313 8.94e-28

beta-ketoacyl-ACP synthase II;


Pssm-ID: 235987 [Multi-domain]  Cd Length: 411  Bit Score: 111.42  E-value: 8.94e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   2 RKEIYITDYNCVTPLGFDVSSNWNALLEGKSGVALhkiIENQEPF-YASMIDSEKLNEEFNRFFDSAQNNNLS-FTRlek 79
Cdd:PRK07314    1 KRRVVVTGLGAVSPLGNDVESTWKNLLAGKSGIGP---ITHFDTSdLAVKIAGEVKDFNPDDYMSRKEARRMDrFIQ--- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  80 MFLLSLKPLVE------KHQISDETAFILSTTKGNISLLKNQKTlpegIFLSSLAQKIADFF-----------------G 136
Cdd:PRK07314   75 YGIAAAKQAVEdagleiTEENADRIGVIIGSGIGGLETIEEQHI----TLLEKGPRRVSPFFvpmaiinmaaghvsiryG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 137 FKTKPIVVSNACVSGVMAIAVAKNMIRAGkYKDAFVIAGDE--ISEFVISGFNSFQAIGTE------ICKPYDKNRDGIN 208
Cdd:PRK07314  151 AKGPNHSIVTACATGAHAIGDAARLIAYG-DADVMVAGGAEaaITPLGIAGFAAARALSTRnddperASRPFDKDRDGFV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 209 IGEAAAAVYItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTAT 288
Cdd:PRK07314  230 MGEGAGILVL---EELEHAKARGAKIYAEVVGYGMTGDAYHMTAPAPDGEGAARAMKLALKDAGINPEDIDYINAHGTST 306

                         330       340
                  ....*....|....*....|....*...
gi 2735215716 289 IYNDEMEAIAFNRM---ELQNVPLNSMK 313
Cdd:PRK07314  307 PAGDKAETQAIKRVfgeHAYKVAVSSTK 334
PRK06501 PRK06501
beta-ketoacyl-ACP synthase;
7-313 1.64e-25

beta-ketoacyl-ACP synthase;


Pssm-ID: 235817 [Multi-domain]  Cd Length: 425  Bit Score: 105.10  E-value: 1.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   7 ITDYNCVTPLGFDVSSNWNALLEGKSGValHKI----IENQEPFYASMID--------SEKLNEefnRFFDSAQNNNLSF 74
Cdd:PRK06501   15 VTGMGVVTSLGQGKADNWAALTAGESGI--HTItrfpTEGLRTRIAGTVDflpespfgASALSE---ALARLAAEEALAQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  75 TRLEK------MFLLSlkPLVE-----KHQISDETAFilSTTKGNISLLKNQKTLPEGIF-----LSSLAQKIADFFGFK 138
Cdd:PRK06501   90 AGIGKgdfpgpLFLAA--PPVElewpaRFALAAAVGD--NDAPSYDRLLRAARGGRFDALherfqFGSIADRLADRFGTR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 139 TKPIVVSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGD-EIS-EFVISgFNSFQAIGTE------ICKPYDKNRDGINIG 210
Cdd:PRK06501  166 GLPISLSTACASGATAIQLGVEAIRRGETDRALCIATDgSVSaEALIR-FSLLSALSTQndppekASKPFSKDRDGFVMA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 211 EAAAAVYItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIY 290
Cdd:PRK06501  245 EGAGALVL---ESLESAVARGAKILGIVAGCGEKADSFHRTRSSPDGSPAIGAIRAALADAGLTPEQIDYINAHGTSTPE 321

                         330       340
                  ....*....|....*....|....*.
gi 2735215716 291 NDEMEAIAFNRM---ELQNVPLNSMK 313
Cdd:PRK06501  322 NDKMEYLGLSAVfgeRLASIPVSSNK 347
PRK05952 PRK05952
beta-ketoacyl-ACP synthase;
4-314 2.31e-25

beta-ketoacyl-ACP synthase;


Pssm-ID: 235653 [Multi-domain]  Cd Length: 381  Bit Score: 104.36  E-value: 2.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   4 EIYITDYNCVTPLGfDVSSNWNALLEGKSGVALHKIIENQEPFYASMIDSEKLneefnrffdsaqnnnlSFTRLEKMFLL 83
Cdd:PRK05952    3 KVVVTGIGLVSALG-DLEQSWQRLLQGKSGIKLHQPFPELPPLPLGLIGNQPS----------------SLEDLTKTVVT 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  84 S-LK------PLVE---------KHQISDET---AFILSTTKGNISLLKNQ--KTLPEgiflsSLAQKIADFFGfkTKPI 142
Cdd:PRK05952   66 AaLKdagltpPLTDcgvvigssrGCQGQWEKlarQMYQGDDSPDEELDLENwlDTLPH-----QAAIAAARQIG--TQGP 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 143 VVS--NACVSGVMAIAVAKNMIRAGKYKDafVIAG---DEISEFVISGFNSFQAIGTEICKPYDKNRDGINIGEAAAAVY 217
Cdd:PRK05952  139 VLApmAACATGLWAIAQGVELIQTGQCQR--VIAGaveAPITPLTLAGFQQMGALAKTGAYPFDRQREGLVLGEGGAILV 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 218 ItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYNDEMEAI 297
Cdd:PRK05952  217 L---ESAELAQKRGAKIYGQILGFGLTCDAYHMSAPEPDGKSAIAAIQQCLARSGLTPEDIDYIHAHGTATRLNDQREAN 293

                         330
                  ....*....|....*..
gi 2735215716 298 AFNRMELQNVPLNSMKG 314
Cdd:PRK05952  294 LIQALFPHRVAVSSTKG 310
PTZ00050 PTZ00050
3-oxoacyl-acyl carrier protein synthase; Provisional
 13-314 9.05e-24

3-oxoacyl-acyl carrier protein synthase; Provisional


Pssm-ID: 240245 [Multi-domain]  Cd Length: 421  Bit Score: 100.54  E-value: 9.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  13 VTPLGFDVSSNWNALLEGKSGV-----------ALHKIIENQEPFYASM---IDSEKLNEEFNR---FFDSAQNNNLSF- 74
Cdd:PTZ00050    2 VTPLGVGAESTWEALIAGKSGIrkltefpkflpDCIPEQKALENLVAAMpcqIAAEVDQSEFDPsdfAPTKRESRATHFa 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  75 ---TRlEKMFLLSLKPLVEKHQisDETAFILSTTKGNIS-LLKNQKTLPEGIFlsslaQKIADFF----------GF--- 137
Cdd:PTZ00050   82 maaAR-EALADAKLDILSEKDQ--ERIGVNIGSGIGSLAdLTDEMKTLYEKGH-----SRVSPYFipkilgnmaaGLvai 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 138 --KTKPIVVS--NACVSGVMAIAVAKNMIRAGKYKdaFVIAG---DEISEFVISGFNSFQAIGTEI-------CKPYDKN 203
Cdd:PTZ00050  154 khKLKGPSGSavTACATGAHCIGEAFRWIKYGEAD--IMICGgteASITPVSFAGFSRMRALCTKYnddpqraSRPFDKD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 204 RDGINIGEAAAAVYItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITE-ANVSTEKIDFIS 282
Cdd:PTZ00050  232 RAGFVMGEGAGILVL---EELEHALRRGAKIYAEIRGYGSSSDAHHITAPHPDGRGARRCMENALKDgANININDVDYVN 308

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2735215716 283 AHGTATIYNDEMEAIAFNRM----ELQNVPLNSMKG 314
Cdd:PTZ00050  309 AHATSTPIGDKIELKAIKKVfgdsGAPKLYVSSTKG 344
PRK06333 PRK06333
beta-ketoacyl-ACP synthase;
1-297 4.85e-19

beta-ketoacyl-ACP synthase;


Pssm-ID: 235781 [Multi-domain]  Cd Length: 424  Bit Score: 86.98  E-value: 4.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   1 MRKEIYITDYNCVTPLGFDVSSNWNALLEGKSGVAL--HKIIENQEPFYASMIDSekLNEEFNRFFDSAQNnnLSFTRLE 78
Cdd:PRK06333    2 NKKRIVVTGMGAVSPLGCGVETFWQRLLAGQSGIRTltDFPVGDLATKIGGQVPD--LAEDAEAGFDPDRY--LDPKDQR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  79 KM--FLL-------------SLKPLVEKHQisDETAFILSTTKGNISLLKN--QKTLPEGI----------FLSSLAQ-K 130
Cdd:PRK06333   78 KMdrFILfamaaakealaqaGWDPDTLEDR--ERTATIIGSGVGGFPAIAEavRTLDSRGPrrlspftipsFLTNMAAgH 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 131 IADFFGFKTKPIVVSNACVSGVMAIAVAKNMIRAGkYKDAFVIAGDE--ISEFVISGFNSFQAIGT-------EICKPYD 201
Cdd:PRK06333  156 VSIRYGFKGPLGAPVTACAAGVQAIGDAARLIRSG-EADVAVCGGTEaaIDRVSLAGFAAARALSTrfndapeQASRPFD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 202 KNRDGINIGEAAAAVYItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFI 281
Cdd:PRK06333  235 RDRDGFVMGEGAGILVI---ETLEHALARGAPPLAELVGYGTSADAYHMTAGPEDGEGARRAMLIALRQAGIPPEEVQHL 311

                         330
                  ....*....|....*...
gi 2735215716 282 SAHGTATIYND--EMEAI 297
Cdd:PRK06333  312 NAHATSTPVGDlgEVAAI 329
PRK08722 PRK08722
beta-ketoacyl-ACP synthase II;
2-301 1.18e-18

beta-ketoacyl-ACP synthase II;


Pssm-ID: 181539 [Multi-domain]  Cd Length: 414  Bit Score: 85.83  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   2 RKEIYITDYNCVTPLGFDVSSNWNALLEGKSGvalhkiIENQEPFYASMIDSE--KLNEEFNrffdsaQNNNLSFTRLEK 79
Cdd:PRK08722    3 KRRVVVTGMGMLSPVGNTVESSWKALLAGQSG------IVNIEHFDTTNFSTRfaGLVKDFN------CEEYMSKKDARK 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  80 MFLLSLKPLVEKHQISDETAFILSTTK------------GNISLLKNQKTlpegIFLSSLAQKIADFF------------ 135
Cdd:PRK08722   71 MDLFIQYGIAAGIQALDDSGLEVTEENahrigvaigsgiGGLGLIEAGHQ----ALVEKGPRKVSPFFvpstivnmiagn 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 136 -----GFKTKPIVVSNACVSGVMAIAVAKNMIRAGKyKDAFVIAGDE--ISEFVISGFNSFQAIGT------EICKPYDK 202
Cdd:PRK08722  147 lsimrGLRGPNIAISTACTTGLHNIGHAARMIAYGD-ADAMVAGGAEkaSTPLGMAGFGAAKALSTrndepqKASRPWDK 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 203 NRDGINIGEAAAAVYITGCHSDEGRisqNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFIS 282
Cdd:PRK08722  226 DRDGFVLGDGAGMMVLEEYEHAKAR---GAKIYAELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGVTGEQIGYVN 302

                         330
                  ....*....|....*....
gi 2735215716 283 AHGTATIYNDEMEAIAFNR 301
Cdd:PRK08722  303 AHGTSTPAGDVAEIKGIKR 321
PRK08439 PRK08439
3-oxoacyl-(acyl carrier protein) synthase II; Reviewed
 3-314 3.35e-17

3-oxoacyl-(acyl carrier protein) synthase II; Reviewed


Pssm-ID: 236265 [Multi-domain]  Cd Length: 406  Bit Score: 81.32  E-value: 3.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   3 KEIYITDYNCVTPLGFDVSSNWNALLEGKSGValHKIienqepfyaSMIDSE----KLNEEFNRFFDSAQNNNLSFTRLE 78
Cdd:PRK08439    2 KRVVVTGIGMINSLGLNKESSFKAICNGECGI--KKI---------TLFDASdfpvQIAGEITDFDPTEVMDPKEVKKAD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  79 KMFLLSLKPLVEKHQIS-------DETAFILSTTKG-----NI---SLLKNQKTlPEGI---FL-SSLAQKIADF----F 135
Cdd:PRK08439   71 RFIQLGLKAAREAMKDAgflpeelDAERFGVSSASGigglpNIeknSIICFEKG-PRKIspfFIpSALVNMLGGFisieH 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 136 GFKTKPIVVSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDE-ISEFVISGFNSFQAIGT------EICKPYDKNRDGIN 208
Cdd:PRK08439  150 GLKGPNLSSVTACAAGTHAIIEAVKTIMLGGADKMLVVGAESaICPVGIGGFAAMKALSTrnddpkKASRPFDKDRDGFV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 209 IGEAAAAVYItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSRtgDGLFSSIKNTITEANVSteKIDFISAHGTAT 288
Cdd:PRK08439  230 MGEGAGALVL---EEYESAKKRGAKIYAEIIGFGESGDANHITSPAP--EGPLRAMKAALEMAGNP--KIDYINAHGTST 302

                         330       340
                  ....*....|....*....|....*....
gi 2735215716 289 IYNDEMEAIAFNRM--ELQNVPL-NSMKG 314
Cdd:PRK08439  303 PYNDKNETAALKELfgSKEKVPPvSSTKG 331
PRK09116 PRK09116
beta-ketoacyl-ACP synthase;
134-313 7.28e-17

beta-ketoacyl-ACP synthase;


Pssm-ID: 181657 [Multi-domain]  Cd Length: 405  Bit Score: 80.42  E-value: 7.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 134 FFGFKTKPIVVSNACVSGVMAIAVAKNMIRAGkYKDAFVIAGDEisEFVISG---FNSFQAIGT------EICKPYDKNR 204
Cdd:PRK09116  150 FFGLKGRVIPTSSACTSGSQGIGYAYEAIKYG-YQTVMLAGGAE--ELCPTEaavFDTLFATSTrndapeLTPRPFDANR 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 205 DGINIGEAAAAVYItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLfsSIKNTITEANVSTEKIDFISAH 284
Cdd:PRK09116  227 DGLVIGEGAGTLVL---EELEHAKARGATIYAEIVGFGTNSDGAHVTQPQAETMQI--AMELALKDAGLAPEDIGYVNAH 301

                         170       180
                  ....*....|....*....|....*....
gi 2735215716 285 GTATIYNDEMEAIAFNRMELQNVPLNSMK 313
Cdd:PRK09116  302 GTATDRGDIAESQATAAVFGARMPISSLK 330
elong_cond_enzymes cd00828
"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ...
 7-314 9.30e-16

"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as primer substrates, as well as the nature of their active site residues.


Pssm-ID: 238424 [Multi-domain]  Cd Length: 407  Bit Score: 77.09  E-value: 9.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   7 ITDYNCVTPLG---FDVSSNWNALLEGKSGVALHKIIENQEP-FYASMIDSeklneefnRFFDSAQNNNLSFTRLEKMFL 82
Cdd:cd00828     5 ITGIGVVSPHGegcDEVEEFWEALREGRSGIAPVARLKSRFDrGVAGQIPT--------GDIPGWDAKRTGIVDRTTLLA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  83 LS----------LKPLVEKHqiSDETAFILSTTKG----------NISLLKNQKTLPEGIFLSSLAQ-KIADFFGFKTKP 141
Cdd:cd00828    77 LVateealadagITDPYEVH--PSEVGVVVGSGMGglrflrrggkLDARAVNPYVSPKWMLSPNTVAgWVNILLLSSHGP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 142 I-VVSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDEISEFVISGFNSFQAIGTEI------CKPYDKNRDGINIGEAAA 214
Cdd:cd00828   155 IkTPVGACATALEALDLAVEAIRSGKADIVVVGGVEDPLEEGLSGFANMGALSTAEeepeemSRPFDETRDGFVEAEGAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 215 AVYITgchSDEGRISQNEKFSFKILGDSAINDANHISGPSrTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYNDEM 294
Cdd:cd00828   235 VLVLE---RAELALARGAPIYGRVAGTASTTDGAGRSVPA-GGKGIARAIRTALAKAGLSLDDLDVISAHGTSTPANDVA 310

                         330       340
                  ....*....|....*....|...
gi 2735215716 295 EAIAFNR---MELQNVPLNSMKG 314
Cdd:cd00828   311 ESRAIAEvagALGAPLPVTAQKA 333
PLN02836 PLN02836
3-oxoacyl-[acyl-carrier-protein] synthase
 7-314 1.62e-15

3-oxoacyl-[acyl-carrier-protein] synthase


Pssm-ID: 215449 [Multi-domain]  Cd Length: 437  Bit Score: 76.37  E-value: 1.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   7 ITDYNCVTPLGFDVSSNWNALLEGKSGV-AL--------HKIIENQEPFY-------ASMIDSEKLNEEFNRffdSAQNN 70
Cdd:PLN02836   10 VTGLGLVTPLGCGVETTWRRLIAGECGVrALtqddlkmkSEDEETQLYTLdqlpsrvAALVPRGTGPGDFDE---ELWLN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  71 NLSFTRLEKMFLLS----LK-----PLVEKHqiSDETAFILSTTKGNIS-LLKNQKTLPEG------------IFLSSLA 128
Cdd:PLN02836   87 SRSSSRFIGYALCAadeaLSdarwlPSEDEA--KERTGVSIGGGIGSITdILEAAQLICEKrlrrlspffvprILINMAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 129 QKIADFFGFKTKPIVVSNACVSGVMAIAVAKNMIRAGKyKDAFVIAGDE--ISEFVISGFNSFQAIGT-------EICKP 199
Cdd:PLN02836  165 GHVSIRYGFQGPNHAAVTACATGAHSIGDAFRMIQFGD-ADVMVAGGTEssIDALSIAGFSRSRALSTkfnscptEASRP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 200 YDKNRDGINIGEAAAAVYITGC-HSDEgrisQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKI 278
Cdd:PLN02836  244 FDCDRDGFVIGEGAGVLVLEELeHAKR----RGAKIYAEVRGYGMSGDAHHITQPHEDGRGAVLAMTRALQQSGLHPNQV 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2735215716 279 DFISAHGTATIYNDEMEAIA-----FNRMELQNVPLNSMKG 314
Cdd:PLN02836  320 DYVNAHATSTPLGDAVEARAiktvfSEHATSGGLAFSSTKG 360
PRK07910 PRK07910
beta-ketoacyl-ACP synthase;
5-301 3.57e-15

beta-ketoacyl-ACP synthase;


Pssm-ID: 236129 [Multi-domain]  Cd Length: 418  Bit Score: 75.54  E-value: 3.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   5 IYITDYNCVTPLGFDVSSNWNALLEGKSGV-ALhkiienQEPFYASMiDSE-----KLNEEFNRFFDSAQNNNLSFtrLE 78
Cdd:PRK07910   14 VVVTGIAMTTALATDAETTWKLLLDGQSGIrTL------DDPFVEEF-DLPvriggHLLEEFDHQLTRVELRRMSY--LQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  79 KMFLL--------SLKPLVEKHQI----------SDETAFILSTTKGN----ISLLKNQKTLPEGIflsslAQKIADFFG 136
Cdd:PRK07910   85 RMSTVlgrrvwenAGSPEVDTNRLmvsigtglgsAEELVFAYDDMRARglraVSPLAVQMYMPNGP-----AAAVGLERH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 137 FKTKPIVVSNACVSGVMAIAVAKNMIRAGKyKDAFVIAGDE--ISEFVISGFNSFQAIGTE-------ICKPYDKNRDGI 207
Cdd:PRK07910  160 AKAGVITPVSACASGSEAIAQAWRQIVLGE-ADIAICGGVEtrIEAVPIAGFAQMRIVMSTnnddpagACRPFDKDRDGF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 208 NIGEAAAAVYItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTA 287
Cdd:PRK07910  239 VFGEGGALMVI---ETEEHAKARGANILARIMGASITSDGFHMVAPDPNGERAGHAMTRAIELAGLTPGDIDHVNAHATG 315

                         330
                  ....*....|....
gi 2735215716 288 TIYNDEMEAIAFNR 301
Cdd:PRK07910  316 TSVGDVAEGKAINN 329
PRK07103 PRK07103
polyketide beta-ketoacyl:acyl carrier protein synthase; Validated
 131-313 4.81e-14

polyketide beta-ketoacyl:acyl carrier protein synthase; Validated


Pssm-ID: 180839 [Multi-domain]  Cd Length: 410  Bit Score: 71.99  E-value: 4.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 131 IADFFGFKTKPIVVSNACVSGVMAIAVAKNMIRAGKYkDAFVIAGD--EISEFVISGFNSFQAIGTE--------ICKPY 200
Cdd:PRK07103  150 CSEQFGIRGEGFTVGGASASGQLAVIQAARLVQSGSV-DACIAVGAlmDLSYWECQALRSLGAMGSDrfadepeaACRPF 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 201 DKNRDGINIGEAAAAVYITGCHSDEGRisqNEKFSFKILGDSAINDANHISGPSrtGDGLFSSIKNTITEANVSTEKIDF 280
Cdd:PRK07103  229 DQDRDGFIYGEACGAVVLESAESARRR---GARPYAKLLGWSMRLDANRGPDPS--LEGEMRVIRAALRRAGLGPEDIDY 303

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2735215716 281 ISAHGTATIYNDEMEAIAFNRMELQNVPLNSMK 313
Cdd:PRK07103  304 VNPHGTGSPLGDETELAALFASGLAHAWINATK 336
decarbox_cond_enzymes cd00825
decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new ...
 121-311 6.04e-13

decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new carbon-carbon bond by a decarboxylating Claisen-like condensation reaction. Members are involved in the synthesis of fatty acids and polyketides, a diverse group of natural products. Both pathways are an iterative series of additions of small carbon units, usually acetate, to a nascent acyl group. There are 2 classes of decarboxylating condensing enzymes, which can be distinguished by sequence similarity, type of active site residues and type of primer units (acetyl CoA or acyl carrier protein (ACP) linked units).


Pssm-ID: 238421 [Multi-domain]  Cd Length: 332  Bit Score: 68.43  E-value: 6.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 121 GIFLSSLAQKIADFFGFKTKPIVVSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDEISEfVISGFNSFQAIGTE---IC 197
Cdd:cd00825    69 KAMFPGASGQIATPLGIHGPAYDVSAACAGSLHALSLAADAVQNGKQDIVLAGGSEELAA-PMDCEFDAMGALSTpekAS 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 198 KPYDKNRDGINIGEAAAAVYITgchSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEK 277
Cdd:cd00825   148 RTFDAAADGFVFGDGAGALVVE---ELEHALARGAHIYAEIVGTAATIDGAGMGAFAPSAEGLARAAKEALAVAGLTVWD 224

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2735215716 278 IDFISAHGTATIYNDEMEAIAfNRMELQNVPLNS 311
Cdd:cd00825   225 IDYLVAHGTGTPIGDVKELKL-LRSEFGDKSPAV 257
PKS cd00833
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different ...
 125-314 1.17e-12

polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.


Pssm-ID: 238429 [Multi-domain]  Cd Length: 421  Bit Score: 67.97  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 125 SSLAQKIADFFGFKTKPIVVSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGD-EISEFVISGFNSFQAIG-TEICKPYDK 202
Cdd:cd00833   147 AFLANRISYFFDLRGPSLTVDTACSSSLVALHLACQSLRSGECDLALVGGVNlILSPDMFVGFSKAGMLSpDGRCRPFDA 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 203 NRDGINIGEAAAAVYITgchsdegRISQNEKFSFKILG---DSAIN-D--ANHISGPSrtGDGLFSSIKNTITEANVSTE 276
Cdd:cd00833   227 DADGYVRGEGVGVVVLK-------RLSDALRDGDRIYAvirGSAVNqDgrTKGITAPS--GEAQAALIRRAYARAGVDPS 297

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2735215716 277 KIDFISAHGTATIYND--EMEAI--AFNRMELQNVPLN--SMKG 314
Cdd:cd00833   298 DIDYVEAHGTGTPLGDpiEVEALakVFGGSRSADQPLLigSVKS 341
PRK14691 PRK14691
3-oxoacyl-(acyl carrier protein) synthase II; Provisional
 147-297 1.84e-12

3-oxoacyl-(acyl carrier protein) synthase II; Provisional


Pssm-ID: 173154 [Multi-domain]  Cd Length: 342  Bit Score: 67.06  E-value: 1.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 147 ACVSGVMAIAVAKNMIRAGKyKDAFVIAGDE--ISEFVISGFNSFQAIGTEI-------CKPYDKNRDGINIGEAAAAVY 217
Cdd:PRK14691   90 ACAAGVQAIGDAVRMIRNNE-ADVALCGGAEavIDTVSLAGFAAARALSTHFnstpekaSRPFDTARDGFVMGEGAGLLI 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 218 ItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYND--EME 295
Cdd:PRK14691  169 I---EELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPVGDlgEIN 245


                  ..
gi 2735215716 296 AI 297
Cdd:PRK14691  246 AI 247
PLN02787 PLN02787
3-oxoacyl-[acyl-carrier-protein] synthase II
 2-313 4.67e-11

3-oxoacyl-[acyl-carrier-protein] synthase II


Pssm-ID: 215421 [Multi-domain]  Cd Length: 540  Bit Score: 63.46  E-value: 4.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   2 RKEIYITDYNCVTPLGFDVSSNWNALLEGKSGvalhkiIENQEPFYASMIdSEKLNEEFNRFFDSAQNNNLSFTRLEKMF 81
Cdd:PLN02787  128 QRRVVVTGMGVVSPLGHDPDVFYNNLLEGVSG------ISEIERFDCSQF-PTRIAGEIKSFSTDGWVAPKLSKRMDKFM 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  82 LLSL---KPLVEKHQISDETAFILSTTKGNI---SLLKNQKTLPEGIFLSSLAQKIADFF------------------GF 137
Cdd:PLN02787  201 LYLLtagKKALADGGITEDVMKELDKTKCGVligSAMGGMKVFNDAIEALRISYRKMNPFcvpfattnmgsamlamdlGW 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 138 KTKPIVVSNACVSGVMAIAVAKNMIRAGKyKDAFVIAGDE--ISEFVISGFNSFQAIG------TEICKPYDKNRDGINI 209
Cdd:PLN02787  281 MGPNYSISTACATSNFCILNAANHIIRGE-ADVMLCGGSDaaIIPIGLGGFVACRALSqrnddpTKASRPWDMNRDGFVM 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 210 GEAAAAVYITGCHSDEGRisqNEKFSFKILGDSAINDANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATI 289
Cdd:PLN02787  360 GEGAGVLLLEELEHAKKR---GANIYAEFLGGSFTCDAYHMTEPHPEGAGVILCIEKALAQSGVSKEDVNYINAHATSTK 436

                         330       340
                  ....*....|....*....|....*.
gi 2735215716 290 YNDEMEAIAFNRMELQNVPL--NSMK 313
Cdd:PLN02787  437 AGDLKEYQALMRCFGQNPELrvNSTK 462
ketoacyl-synt pfam00109
Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar ...
 3-216 3.45e-09

Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.


Pssm-ID: 425468 [Multi-domain]  Cd Length: 251  Bit Score: 56.49  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716   3 KEIYITDYNCVTPLGFDVSSNWNALLEGKSGVA--------------LHKIIENQEPFYASMIDSEklnEEF-NRFFDSA 67
Cdd:pfam00109   1 EPVAIVGMGCRFPGGNDPEEFWENLLEGRDGISeipadrwdpdklydPPSRIAGKIYTKWGGLDDI---FDFdPLFFGIS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716  68 QNNNLSFTRLEKMFLLSLKPLVE------KHQISDETAFIL---STTKGNISLLKNQK------TLPEGIFLSSLAQKIA 132
Cdd:pfam00109  78 PREAERMDPQQRLLLEAAWEALEdagitpDSLDGSRTGVFIgsgIGDYAALLLLDEDGgprrgsPFAVGTMPSVIAGRIS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 133 DFFGFKTKPIVVSNACVSGVMAIAVAKNMIRAGKyKDAfVIAG---DEISEFVISGfnsFQAIG----TEICKPYDKNRD 205
Cdd:pfam00109 158 YFLGLRGPSVTVDTACSSSLVAIHAAVQSIRSGE-ADV-ALAGgvnLLLTPLGFAG---FSAAGmlspDGPCKAFDPFAD 232

                         250
                  ....*....|.
gi 2735215716 206 GINIGEAAAAV 216
Cdd:pfam00109 233 GFVRGEGVGAV 243
Ketoacyl-synt_C pfam02801
Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar ...
 238-298 1.78e-08

Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.


Pssm-ID: 426989  Cd Length: 118  Bit Score: 51.80  E-value: 1.78e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2735215716 238 ILGdSAIN-DANHISGPSRTGDGLFSSIKNTITEANVSTEKIDFISAHGTATIYND--EMEAIA 298
Cdd:pfam02801   4 IKG-SAVNhDGRHNGLTAPNGEGQARAIRRALADAGVDPEDVDYVEAHGTGTPLGDpiEAEALK 66
ACP_syn_III pfam08545
3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; This domain is found on 3-Oxoacyl- ...
 144-228 1.33e-06

3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.180, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.


Pssm-ID: 430064 [Multi-domain]  Cd Length: 80  Bit Score: 45.58  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 144 VSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDEISEFVisgfnsfqaigteicKPYDKNRdGINIGEAAAAVYITGCHS 223
Cdd:pfam08545   3 INAACSGFVYALSTAAALIRSGRAKNVLVIGAETLSKIL---------------DWTDRST-AVLFGDGAGAVVLEATDE 66


                  ....*
gi 2735215716 224 DEGRI 228
Cdd:pfam08545  67 PGARI 71
init_cond_enzymes cd00827
"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ...
 126-176 4.93e-06

"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the utlization of CoA substrate primers, as well as the nature of their active site residues.


Pssm-ID: 238423 [Multi-domain]  Cd Length: 324  Bit Score: 47.43  E-value: 4.93e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2735215716 126 SLAQKIADFFGFK-TKPIVVSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGD 176
Cdd:cd00827    86 SAATYLAELLGLTnAEAFDLKQACYGGTAALQLAANLVESGPWRYALVVASD 137
PRK07967 PRK07967
beta-ketoacyl-ACP synthase I;
125-297 7.24e-06

beta-ketoacyl-ACP synthase I;


Pssm-ID: 181184 [Multi-domain]  Cd Length: 406  Bit Score: 46.97  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 125 SSLAQKIADFFGFKTKPIVVSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDEISEFVISGFNSFQAIGTE-------IC 197
Cdd:PRK07967  139 STVSACLATPFKIKGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELDWEMSCLFDAMGALSTKyndtpekAS 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 198 KPYDKNRDGINIGEAAAAVYItgcHSDEGRISQNEKFSFKILGDSAINDANHISGPSrtGDGLFSSIKNTIteANVSTeK 277
Cdd:PRK07967  219 RAYDANRDGFVIAGGGGVVVV---EELEHALARGAKIYAEIVGYGATSDGYDMVAPS--GEGAVRCMQMAL--ATVDT-P 290

                         170       180
                  ....*....|....*....|..
gi 2735215716 278 IDFISAHGTATIYND--EMEAI 297
Cdd:PRK07967  291 IDYINTHGTSTPVGDvkELGAI 312
cond_enzymes cd00327
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ...
 105-288 1.79e-05

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.


Pssm-ID: 238201 [Multi-domain]  Cd Length: 254  Bit Score: 45.51  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 105 TKGNISLLKNQKTLPEGIFlSSLAQKIADFFGFKTKP-IVVSNACVSGVMAIAVAKNMIRAGKYKDAFviagdeisefvi 183
Cdd:cd00327    25 SKGPIVGVIVGTTGGSGEF-SGAAGQLAYHLGISGGPaYSVNQACATGLTALALAVQQVQNGKADIVL------------ 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 184 sgfnsfqAIGTEICKPydknRDGinigeAAAAVYITGCHSDEgrisQNEKFSFKILG-DSAINDANHISGPSrtGDGLFS 262
Cdd:cd00327    92 -------AGGSEEFVF----GDG-----AAAAVVESEEHALR----RGAHPQAEIVStAATFDGASMVPAVS--GEGLAR 149

                         170       180
                  ....*....|....*....|....*.
gi 2735215716 263 SIKNTITEANVSTEKIDFISAHGTAT 288
Cdd:cd00327   150 AARKALEGAGLTPSDIDYVEAHGTGT 175
KAS_III cd00830
Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty ...
 144-284 1.91e-05

Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.


Pssm-ID: 238426 [Multi-domain]  Cd Length: 320  Bit Score: 45.61  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 144 VSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDeisefVISGFNSFQAIGTEickpydknrdgINIGEAAAAVYITGCHS 223
Cdd:cd00830   107 INAACSGFLYGLSTAAGLIRSGGAKNVLVVGAE-----TLSRILDWTDRSTA-----------VLFGDGAGAVVLEATEE 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2735215716 224 DEGRI--------SQNEKFSFKILGDSAINDANHISGPSRTGDG--LFS--------SIKNTITEANVSTEKIDFISAH 284
Cdd:cd00830   171 DPGILdsvlgsdgSGADLLTIPAGGSRSPFEDAEGGDPYLVMDGreVFKfavrlmpeSIEEALEKAGLTPDDIDWFVPH 249
FabH COG0332
3-oxoacyl-[acyl-carrier-protein] synthase III [Lipid transport and metabolism]; 3-oxoacyl- ...
 144-182 2.38e-05

3-oxoacyl-[acyl-carrier-protein] synthase III [Lipid transport and metabolism]; 3-oxoacyl-[acyl-carrier-protein] synthase III is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440101 [Multi-domain]  Cd Length: 323  Bit Score: 45.10  E-value: 2.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2735215716 144 VSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDEISEFV 182
Cdd:COG0332   108 INAACSGFVYALSVAAALIRSGQAKNVLVVGAETLSRIV 146
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
 121-217 1.13e-04

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 43.41  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 121 GIFLSSLAQKIADFFGFKTKPIV-VSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDEISefviSGFNSFQAIGTEIckP 199
Cdd:cd00829    49 GRFQSFPGALIAEYLGLLGKPATrVEAAGASGSAAVRAAAAAIASGLADVVLVVGAEKMS----DVPTGDEAGGRAS--D 122

                          90
                  ....*....|....*...
gi 2735215716 200 YDKNRDGINIGEAAAAVY 217
Cdd:cd00829   123 LEWEGPEPPGGLTPPALY 140
CH_MICAL2 cd21250
calponin homology (CH) domain found in molecule interacting with CasL protein 2; MICAL-2 is a ...
 19-81 8.50e-04

calponin homology (CH) domain found in molecule interacting with CasL protein 2; MICAL-2 is a nuclear [F-actin]-monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). MICAL-2 acts as a key regulator of the serum response factor (SRF) signaling pathway elicited by nerve growth factor and serum. It mediates oxidation and subsequent depolymerization of nuclear actin, leading to the increased MKL1/MRTF-A presence in the nucleus, promoting SRF:MKL1/MRTF-A-dependent gene transcription. MICAL-2 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409099 [Multi-domain]  Cd Length: 110  Bit Score: 38.32  E-value: 8.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2735215716  19 DVSSNWnallegKSGVALHKIIENQEPfyaSMIDSEKLNEEfnrffDSAQNNNLSFTRLEKMF 81
Cdd:cd21250    27 DLTTSW------KSGLALCAIIHRFRP---ELIDFDSLNED-----DAVKNNQLAFDVAEREF 75
PRK09352 PRK09352
beta-ketoacyl-ACP synthase 3;
144-182 1.46e-03

beta-ketoacyl-ACP synthase 3;


Pssm-ID: 236475 [Multi-domain]  Cd Length: 319  Bit Score: 39.67  E-value: 1.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2735215716 144 VSNACvSG-VMAIAVAKNMIRAGKYKDAFVIAGDEISEFV 182
Cdd:PRK09352  109 LSAAC-SGfVYALSTADQFIRSGAYKNVLVIGAEKLSRIV 147
PRK06147 PRK06147
3-oxoacyl-(acyl carrier protein) synthase; Validated
 125-281 1.65e-03

3-oxoacyl-(acyl carrier protein) synthase; Validated


Pssm-ID: 235715 [Multi-domain]  Cd Length: 348  Bit Score: 39.62  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 125 SSLAQKIADFFGFKTKP--IVVSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDeiSEFVISGFNSFQAIGTEICKPydk 202
Cdd:PRK06147  108 ERLLRELEARLGLRLEPgsAVIARGRVSGAVALAQARRLIAAGGCPRVLVAGVD--SLLTGPTLAHYEARDRLLTSQ--- 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735215716 203 NRDGINIGEAAAAVYItgchsdeGRISQNEKFSFKILGDSAINDANHISG----PSRtGDGLFSSIKNTITEANVSTEKI 278
Cdd:PRK06147  183 NSNGFIPGEAAAAVLL-------GRPAGGEAPGLPLLGLGLGREPAPVGEsedlPLR-GDGLTQAIRAALAEAGCGLEDM 254


                  ...
gi 2735215716 279 DFI 281
Cdd:PRK06147  255 DYR 257
PRK12879 PRK12879
3-oxoacyl-(acyl carrier protein) synthase III; Reviewed
 126-181 3.23e-03

3-oxoacyl-(acyl carrier protein) synthase III; Reviewed


Pssm-ID: 237245 [Multi-domain]  Cd Length: 325  Bit Score: 38.69  E-value: 3.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2735215716 126 SLAQKIADFFGFKTKPIV-VSNACVSGVMAIAVAKNMIRAGKYKDAFVIAGDEISEF 181
Cdd:PRK12879   91 STASQVQARLGIPNAAAFdINAACAGFLYGLETANGLITSGLYKKVLVIGAERLSKV 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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