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Conserved domains on  [gi|2738573402|ref|WP_348471077|]
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cyclic pyranopterin monophosphate synthase MoaC [Cobetia amphilecti]

Protein Classification

MoaD/ThiS family protein; molybdenum cofactor biosynthesis protein 1( domain architecture ID 12848854)

MoaD/ThiS family protein is a ubiquitin-like protein, may be involved in sulfur transfer; molybdenum cofactor biosynthesis protein 1 catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
moaC PRK09364
cyclic pyranopterin monophosphate synthase MoaC;
1-158 2.13e-102

cyclic pyranopterin monophosphate synthase MoaC;


:

Pssm-ID: 236483  Cd Length: 159  Bit Score: 295.56  E-value: 2.13e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   1 MSLTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALML 80
Cdd:PRK09364    2 SQLTHINEQGRAKMVDVSDKAETVRTAVAEGSVRMSPETLALIRDGTAKKGDVLATARIAGIMAAKRTSDLIPLCHPLML 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2738573402  81 SKVTVDFTLDSANSCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSGDWQRPE 158
Cdd:PRK09364   82 TGVDVDFEWDPELPGVRITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDVRLLEKSGGKSGDFKREA 159
MoaD COG1977
Molybdopterin synthase sulfur carrier subunit MoaD [Coenzyme transport and metabolism]; ...
 206-287 5.35e-24

Molybdopterin synthase sulfur carrier subunit MoaD [Coenzyme transport and metabolism]; Molybdopterin synthase sulfur carrier subunit MoaD is part of the Pathway/BioSystem: Molybdopterin biosynthesis


:

Pssm-ID: 441580 [Multi-domain]  Cd Length: 82  Bit Score: 92.57  E-value: 5.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTtlSEATVGGLKRTLALRDPQL-EALNDTRVLCAVNQDMVRDDHPLNAGDEVAFFPPV 284
Cdd:COG1977     2 VTVRYFAALREAAGKSEEEVELP--EGATVGDLLEALAARYPGLaERLLRRRVRVAVNGEDVRLDTPLKDGDEVALFPPV 79


                  ...
gi 2738573402 285 TGG 287
Cdd:COG1977    80 AGG 82
 
Name Accession Description Interval E-value
moaC PRK09364
cyclic pyranopterin monophosphate synthase MoaC;
1-158 2.13e-102

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 236483  Cd Length: 159  Bit Score: 295.56  E-value: 2.13e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   1 MSLTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALML 80
Cdd:PRK09364    2 SQLTHINEQGRAKMVDVSDKAETVRTAVAEGSVRMSPETLALIRDGTAKKGDVLATARIAGIMAAKRTSDLIPLCHPLML 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2738573402  81 SKVTVDFTLDSANSCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSGDWQRPE 158
Cdd:PRK09364   82 TGVDVDFEWDPELPGVRITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDVRLLEKSGGKSGDFKREA 159
MoaC COG0315
Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum ...
 1-152 3.06e-101

Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum cofactor biosynthesis enzyme MoaC is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440084  Cd Length: 153  Bit Score: 292.35  E-value: 3.06e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   1 MSLTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALML 80
Cdd:COG0315     2 SELTHLDEQGRARMVDVSDKAVTARTAVAEGRVRMSPETLALIREGGVKKGDVLAVARIAGIMAAKRTSELIPLCHPLPL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2738573402  81 SKVTVDFTLDSANSCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSG 152
Cdd:COG0315    82 TGVDVDFELDDDLSGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIEDIRLLEKSGGKSG 153
MoaC pfam01967
MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However ...
 14-149 9.94e-85

MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.


Pssm-ID: 460399  Cd Length: 136  Bit Score: 249.96  E-value: 9.94e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  14 MVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSKVTVDFTLDSAN 93
Cdd:pfam01967   1 MVDVSDKPVTLRTAVAEGRIRLSPETLELIREGTVKKGDVLAVARIAGIMAAKKTSDLIPLCHPLPLTGVDVEFELDEEE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2738573402  94 SCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGG 149
Cdd:pfam01967  81 DGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDIRLLEKSGG 136
MoaC_PE cd01420
MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum ...
 14-153 1.54e-82

MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238708  Cd Length: 140  Bit Score: 244.76  E-value: 1.54e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  14 MVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSKVTVDFTLDSAN 93
Cdd:cd01420     1 MVDVSDKAVTERTAVAEGRVRMSPETLDLITEGQLPKGDVLAVARIAGIMAAKRTSELIPLCHPLPLTGVDVDFELDEET 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  94 SCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSGD 153
Cdd:cd01420    81 SGVRIEATVRTTGRTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGGIRLLEKSGGKSGD 140
moaC TIGR00581
molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum ...
 3-151 2.74e-72

molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum cofactor biosynthesis in E. coli. The Arabidopsis homolog Cnx3 complements MoaC deficiency in E. coli. Eukarotic members of this family branch within the bacterial branch, with the archaeal members as an apparent outgroup. This protein is absent in a number of the pathogens with smaller genomes, including Mycoplasmas, Chlamydias, and spirochetes, but is found in most other complete genomes to date. The homolog form Synechocystis sp. is fused to a MobA-homologous region and is an outlier to all other bacterial forms by both neighbor-joining and UPGMA analyses. Members of this family are well-conserved. The seed for this model excludes both archaeal sequences and the most divergent bacterial sequences, but still finds all candidate MoaC sequences easily between trusted and noise cutoffs. We suggest that sequences branching outside the set that contains all seed members be regarded only as putative functional equivalents of MoaC unless and until a member of the archaeal outgroup is shown to have equivalent function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 129670  Cd Length: 147  Bit Score: 218.84  E-value: 2.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   3 LTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSK 82
Cdd:TIGR00581   1 LTHIDEQGAARMVDISAKAETVREAVASGFVRMKPETVAMISEGRVPKGDVLATARVAGIMAAKRTGDLIPLCHPLPLSK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2738573402  83 VTVDFTLDSANscVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKS 151
Cdd:TIGR00581  81 VEVELTVREDR--VEITATVRTTGRTGVEMEALTAVSVAALTVYDMCKAVDKDMVIGPVRLLEKSGGKS 147
MoaD COG1977
Molybdopterin synthase sulfur carrier subunit MoaD [Coenzyme transport and metabolism]; ...
 206-287 5.35e-24

Molybdopterin synthase sulfur carrier subunit MoaD [Coenzyme transport and metabolism]; Molybdopterin synthase sulfur carrier subunit MoaD is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 441580 [Multi-domain]  Cd Length: 82  Bit Score: 92.57  E-value: 5.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTtlSEATVGGLKRTLALRDPQL-EALNDTRVLCAVNQDMVRDDHPLNAGDEVAFFPPV 284
Cdd:COG1977     2 VTVRYFAALREAAGKSEEEVELP--EGATVGDLLEALAARYPGLaERLLRRRVRVAVNGEDVRLDTPLKDGDEVALFPPV 79


                  ...
gi 2738573402 285 TGG 287
Cdd:COG1977    80 AGG 82
moaD TIGR01682
molybdopterin converting factor, subunit 1, non-archaeal; This model describes MoaD. It ...
 206-287 1.09e-19

molybdopterin converting factor, subunit 1, non-archaeal; This model describes MoaD. It excludes archaeal homologs, since many Archaea have two MoaD-like proteins, suggesting two different functions. pfam02597 describes both the thiamine biosynthesis protein ThiS and this protein, MoaD, a subunit (together with MoaE, pfam02391) of the molybdopterin converting factor. Both ThiS and MoaD are involved in sulfur transfer reactions. Distribution of this family appears limited to species that also have a member of pfam02391, but a number of Archaea have two different members, suggesting functionally distinct subtypes. The C-terminal Gly-Gly of this model is critical to function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 273753  Cd Length: 80  Bit Score: 81.19  E-value: 1.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTTLSeATVGGLKRTLALRDPQLeALNDTRVLCAVNQDMVRDDHPLNAGDEVAFFPPVT 285
Cdd:TIGR01682   1 IKVLYFARLREQAGTDEETLELPDES-TTVGELKEHLAKEGPEL-AASRGQVMVAVNEEYVTDDALLNEGDEVAFIPPVS 78


                  ..
gi 2738573402 286 GG 287
Cdd:TIGR01682  79 GG 80
moaD PRK11130
molybdopterin synthase small subunit; Provisional
 206-287 3.40e-18

molybdopterin synthase small subunit; Provisional


Pssm-ID: 182985  Cd Length: 81  Bit Score: 77.31  E-value: 3.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTTlseATVGGLKRTLALRDPQLE-ALNDTRVLCAVNQDMVRDDHPLNAGDEVAFFPPV 284
Cdd:PRK11130    2 IKVLFFAQVRELVGTDALELAADF---PTVEALRQHLAQKGDRWAlALEDGKLLAAVNQTLVSFDHPLTDGDEVAFFPPV 78


                  ...
gi 2738573402 285 TGG 287
Cdd:PRK11130   79 TGG 81
Ubl_MoaD cd00754
ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and ...
 206-287 1.79e-16

ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins; MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.


Pssm-ID: 340452  Cd Length: 79  Bit Score: 72.61  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTTlsEATVGGLKRTLALRDPQLEALNDTrVLCAVNQDMVRDDHPLNAGDEVAFFPPVT 285
Cdd:cd00754     1 VKVLYFARARELAGKSEEELELPA--GTTVEELLEELAAKYPALAAILKS-VRVAVNQEYVDDDTELKDGDEVAFIPPVS 77


                  ..
gi 2738573402 286 GG 287
Cdd:cd00754    78 GG 79
ThiS pfam02597
ThiS family; ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer. ThiS is coded in ...
 208-287 2.70e-15

ThiS family; ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer. ThiS is coded in the thiCEFSGH operon in E. coli. This family of proteins have two conserved Glycines at the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalyzed by IscS. MoaD, a protein involved sulphur transfer in molybdopterin synthesis, is about the same length and shows limited sequence similarity to ThiS. Both have the conserved GG at the COOH end.


Pssm-ID: 396932 [Multi-domain]  Cd Length: 74  Bit Score: 69.24  E-value: 2.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 208 VLFLAELRERLDLDSLALNLTTLSEatvggLKRTLALRDPQLEAlndtRVLCAVNQDMVR---DDHPLNAGDEVAFFPPV 284
Cdd:pfam02597   1 VLLNAELRELAGKDEELAEGATVAE-----LLEALGLRYPELRE----RVAVAVNGEIVPrlwLDTPLKDGDEVAIIPPV 71


                  ...
gi 2738573402 285 TGG 287
Cdd:pfam02597  72 GGG 74
 
Name Accession Description Interval E-value
moaC PRK09364
cyclic pyranopterin monophosphate synthase MoaC;
1-158 2.13e-102

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 236483  Cd Length: 159  Bit Score: 295.56  E-value: 2.13e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   1 MSLTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALML 80
Cdd:PRK09364    2 SQLTHINEQGRAKMVDVSDKAETVRTAVAEGSVRMSPETLALIRDGTAKKGDVLATARIAGIMAAKRTSDLIPLCHPLML 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2738573402  81 SKVTVDFTLDSANSCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSGDWQRPE 158
Cdd:PRK09364   82 TGVDVDFEWDPELPGVRITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDVRLLEKSGGKSGDFKREA 159
MoaC COG0315
Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum ...
 1-152 3.06e-101

Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum cofactor biosynthesis enzyme MoaC is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440084  Cd Length: 153  Bit Score: 292.35  E-value: 3.06e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   1 MSLTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALML 80
Cdd:COG0315     2 SELTHLDEQGRARMVDVSDKAVTARTAVAEGRVRMSPETLALIREGGVKKGDVLAVARIAGIMAAKRTSELIPLCHPLPL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2738573402  81 SKVTVDFTLDSANSCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSG 152
Cdd:COG0315    82 TGVDVDFELDDDLSGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIEDIRLLEKSGGKSG 153
MoaC pfam01967
MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However ...
 14-149 9.94e-85

MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.


Pssm-ID: 460399  Cd Length: 136  Bit Score: 249.96  E-value: 9.94e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  14 MVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSKVTVDFTLDSAN 93
Cdd:pfam01967   1 MVDVSDKPVTLRTAVAEGRIRLSPETLELIREGTVKKGDVLAVARIAGIMAAKKTSDLIPLCHPLPLTGVDVEFELDEEE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2738573402  94 SCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGG 149
Cdd:pfam01967  81 DGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDIRLLEKSGG 136
MoaC_PE cd01420
MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum ...
 14-153 1.54e-82

MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238708  Cd Length: 140  Bit Score: 244.76  E-value: 1.54e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  14 MVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSKVTVDFTLDSAN 93
Cdd:cd01420     1 MVDVSDKAVTERTAVAEGRVRMSPETLDLITEGQLPKGDVLAVARIAGIMAAKRTSELIPLCHPLPLTGVDVDFELDEET 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  94 SCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSGD 153
Cdd:cd01420    81 SGVRIEATVRTTGRTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGGIRLLEKSGGKSGD 140
MoaC cd00528
MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, ...
 14-149 3.06e-76

MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238293  Cd Length: 136  Bit Score: 228.56  E-value: 3.06e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  14 MVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSKVTVDFTLDSAN 93
Cdd:cd00528     1 MVDVSDKAVTERTAVAEGRVRLSPETLDLIREGQLPKGDVLAVARIAGIMAAKRTSELIPLCHPLPLTGVDVDFELDEDT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2738573402  94 SCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGG 149
Cdd:cd00528    81 SGVRIRATVRTTGKTGVEMEALTAVSVAALTIYDMCKAVDKDMVIENIRLLEKSGG 136
moaC TIGR00581
molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum ...
 3-151 2.74e-72

molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum cofactor biosynthesis in E. coli. The Arabidopsis homolog Cnx3 complements MoaC deficiency in E. coli. Eukarotic members of this family branch within the bacterial branch, with the archaeal members as an apparent outgroup. This protein is absent in a number of the pathogens with smaller genomes, including Mycoplasmas, Chlamydias, and spirochetes, but is found in most other complete genomes to date. The homolog form Synechocystis sp. is fused to a MobA-homologous region and is an outlier to all other bacterial forms by both neighbor-joining and UPGMA analyses. Members of this family are well-conserved. The seed for this model excludes both archaeal sequences and the most divergent bacterial sequences, but still finds all candidate MoaC sequences easily between trusted and noise cutoffs. We suggest that sequences branching outside the set that contains all seed members be regarded only as putative functional equivalents of MoaC unless and until a member of the archaeal outgroup is shown to have equivalent function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 129670  Cd Length: 147  Bit Score: 218.84  E-value: 2.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   3 LTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSK 82
Cdd:TIGR00581   1 LTHIDEQGAARMVDISAKAETVREAVASGFVRMKPETVAMISEGRVPKGDVLATARVAGIMAAKRTGDLIPLCHPLPLSK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2738573402  83 VTVDFTLDSANscVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKS 151
Cdd:TIGR00581  81 VEVELTVREDR--VEITATVRTTGRTGVEMEALTAVSVAALTVYDMCKAVDKDMVIGPVRLLEKSGGKS 147
moaC PRK03604
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
 4-162 1.03e-70

bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional


Pssm-ID: 235138 [Multi-domain]  Cd Length: 312  Bit Score: 220.58  E-value: 1.03e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   4 THLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSKV 83
Cdd:PRK03604    1 THLDEEGRVRMVDVSGKPGTLRTARASGIIVTSPETIELLRQGDLPKGDVLTTAKIAGIQAAKRTSELIPLCHPLPLSWV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2738573402  84 TVDFTLDSANscVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSGDWQRPEEAAA 162
Cdd:PRK03604   81 DVEFEIEDDR--IRIEATVKTIGKTGVEMEALTAVSVAALTIYDMLKPVDKALEIGGIRLLEKTGGKSGHKRRFRPRTS 157
PRK14499 PRK14499
cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;
1-190 6.76e-60

cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;


Pssm-ID: 237733 [Multi-domain]  Cd Length: 308  Bit Score: 192.77  E-value: 6.76e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   1 MSLTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALML 80
Cdd:PRK14499    1 MEFTHFNKDGLPQMVDVSSKEPTFRVAVASGRIYVGKEVIEAIEERLLPKGDVFSVAKIAAIMAAKKTSELIPLCHNIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  81 SKVTVDFTLDSANSCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSGDWQRPEEA 160
Cdd:PRK14499   81 SGVDVSYEINREEGYIEAVSEVKTEAKTGAEMEAITAVSIFLETIYDMCKAVKKDMVITDVRLIEKSGGKSGHYIFERRN 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 2738573402 161 AAVEQTSVepSWSEPSRTEPSPAETAEPIE 190
Cdd:PRK14499  161 KTAKVVSI--NISRQKGTPKEPVEEAVLIE 188
PLN02375 PLN02375
molybderin biosynthesis protein CNX3
 3-156 3.75e-44

molybderin biosynthesis protein CNX3


Pssm-ID: 178003 [Multi-domain]  Cd Length: 270  Bit Score: 151.07  E-value: 3.75e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   3 LTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSK 82
Cdd:PLN02375  116 LTHVGIAGEAQMVDVSSKDNSKRTALACCKVILGKRVFDLVLANQMGKGDVLGVAKIAGINGAKQTSSLIPLCHNIALTH 195

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2738573402  83 VTVDFTLDSANSCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSGDWQR 156
Cdd:PLN02375  196 VRVDLRLNPEDFSVDIEGEASCTGKTGVEMEAMTAVSVAGLTVYDMCKAASKDISITDVRLERKTGGKSGSWSR 269
PRK12343 PRK12343
cyclic pyranopterin monophosphate synthase MoaC;
10-134 8.14e-44

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 237067  Cd Length: 151  Bit Score: 146.21  E-value: 8.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  10 GEAHMVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSKVTVDFTL 89
Cdd:PRK12343    5 DGVKMVDVSEKEDVLRIAVAEGFIKLKPETIEAIREGEVEKGNVLATARVAGILAVKKTPELIPMCHPIPITGVDVDFEV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2738573402  90 DsaNSCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDK 134
Cdd:PRK12343   85 G--EDGIEARVTVKTTYKTGVEMEALTGVSVALLTIWDMVKAAEK 127
MoaC_A cd01419
MoaC family, archaeal. Members of this family are involved in molybdenum cofactor (Moco) ...
 14-146 5.11e-43

MoaC family, archaeal. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238707  Cd Length: 141  Bit Score: 144.04  E-value: 5.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  14 MVDVADKQETRREARASARVSMLPATLALLAEGGLPKGDVLATARIAGIQAAKRTHELIPLCHALMLSKVTVDFTLDsaN 93
Cdd:cd01419     1 MVDISSKEDVAREAVASGFIKLKEETIKAIREGKVEKGNVIATARIAGILAVKKTPELIPMCHPIPITGVDVDFEVE--E 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402  94 SCVEIQVLCRLNGRTGVEMEALTAASVAALTLYDMCKAVDK-------GIVIGDIQLETK 146
Cdd:cd01419    79 DGIEVRCTVKTTYKTGVEMEALTGVSVALLTIWDMVKSAEKdedgqypETRIENVRVVEK 138
PRK14500 PRK14500
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; ...
 3-157 5.14e-41

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; Provisional


Pssm-ID: 237734 [Multi-domain]  Cd Length: 346  Bit Score: 145.04  E-value: 5.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402   3 LTHLNARGEAHMVDVADKQETRREARASARVSMLPATLALLAEGG--LPKGDVLATARIAGIQAAKRTHELIPLCHALML 80
Cdd:PRK14500    2 FTHLNENQQPRMVDISQKVVSDRRAVAQAIVQLPPAIKDYVTGQDifLKKGPVIQTAIIAGTMAVKRTADLIPFCHTLPI 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2738573402  81 SKVTVDFTLDSANSCVEIQVLC--RLNGRTGVEMEALTAASVAALTLYDMCKAVDKGIVIGDIQLETKTGGKSGDWQRP 157
Cdd:PRK14500   82 HGCKFDINIVYQKRDLEIFLQCavKTNYKTGVEMEALCGVAVAALTIYDMCKSISPHIIIKETRLIEKSGGKADLSQTP 160
MoaD COG1977
Molybdopterin synthase sulfur carrier subunit MoaD [Coenzyme transport and metabolism]; ...
 206-287 5.35e-24

Molybdopterin synthase sulfur carrier subunit MoaD [Coenzyme transport and metabolism]; Molybdopterin synthase sulfur carrier subunit MoaD is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 441580 [Multi-domain]  Cd Length: 82  Bit Score: 92.57  E-value: 5.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTtlSEATVGGLKRTLALRDPQL-EALNDTRVLCAVNQDMVRDDHPLNAGDEVAFFPPV 284
Cdd:COG1977     2 VTVRYFAALREAAGKSEEEVELP--EGATVGDLLEALAARYPGLaERLLRRRVRVAVNGEDVRLDTPLKDGDEVALFPPV 79


                  ...
gi 2738573402 285 TGG 287
Cdd:COG1977    80 AGG 82
moaD TIGR01682
molybdopterin converting factor, subunit 1, non-archaeal; This model describes MoaD. It ...
 206-287 1.09e-19

molybdopterin converting factor, subunit 1, non-archaeal; This model describes MoaD. It excludes archaeal homologs, since many Archaea have two MoaD-like proteins, suggesting two different functions. pfam02597 describes both the thiamine biosynthesis protein ThiS and this protein, MoaD, a subunit (together with MoaE, pfam02391) of the molybdopterin converting factor. Both ThiS and MoaD are involved in sulfur transfer reactions. Distribution of this family appears limited to species that also have a member of pfam02391, but a number of Archaea have two different members, suggesting functionally distinct subtypes. The C-terminal Gly-Gly of this model is critical to function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 273753  Cd Length: 80  Bit Score: 81.19  E-value: 1.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTTLSeATVGGLKRTLALRDPQLeALNDTRVLCAVNQDMVRDDHPLNAGDEVAFFPPVT 285
Cdd:TIGR01682   1 IKVLYFARLREQAGTDEETLELPDES-TTVGELKEHLAKEGPEL-AASRGQVMVAVNEEYVTDDALLNEGDEVAFIPPVS 78


                  ..
gi 2738573402 286 GG 287
Cdd:TIGR01682  79 GG 80
moaD PRK11130
molybdopterin synthase small subunit; Provisional
 206-287 3.40e-18

molybdopterin synthase small subunit; Provisional


Pssm-ID: 182985  Cd Length: 81  Bit Score: 77.31  E-value: 3.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTTlseATVGGLKRTLALRDPQLE-ALNDTRVLCAVNQDMVRDDHPLNAGDEVAFFPPV 284
Cdd:PRK11130    2 IKVLFFAQVRELVGTDALELAADF---PTVEALRQHLAQKGDRWAlALEDGKLLAAVNQTLVSFDHPLTDGDEVAFFPPV 78


                  ...
gi 2738573402 285 TGG 287
Cdd:PRK11130   79 TGG 81
Ubl_MoaD cd00754
ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and ...
 206-287 1.79e-16

ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins; MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.


Pssm-ID: 340452  Cd Length: 79  Bit Score: 72.61  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTTlsEATVGGLKRTLALRDPQLEALNDTrVLCAVNQDMVRDDHPLNAGDEVAFFPPVT 285
Cdd:cd00754     1 VKVLYFARARELAGKSEEELELPA--GTTVEELLEELAAKYPALAAILKS-VRVAVNQEYVDDDTELKDGDEVAFIPPVS 77


                  ..
gi 2738573402 286 GG 287
Cdd:cd00754    78 GG 79
ThiS pfam02597
ThiS family; ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer. ThiS is coded in ...
 208-287 2.70e-15

ThiS family; ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer. ThiS is coded in the thiCEFSGH operon in E. coli. This family of proteins have two conserved Glycines at the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalyzed by IscS. MoaD, a protein involved sulphur transfer in molybdopterin synthesis, is about the same length and shows limited sequence similarity to ThiS. Both have the conserved GG at the COOH end.


Pssm-ID: 396932 [Multi-domain]  Cd Length: 74  Bit Score: 69.24  E-value: 2.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 208 VLFLAELRERLDLDSLALNLTTLSEatvggLKRTLALRDPQLEAlndtRVLCAVNQDMVR---DDHPLNAGDEVAFFPPV 284
Cdd:pfam02597   1 VLLNAELRELAGKDEELAEGATVAE-----LLEALGLRYPELRE----RVAVAVNGEIVPrlwLDTPLKDGDEVAIIPPV 71


                  ...
gi 2738573402 285 TGG 287
Cdd:pfam02597  72 GGG 74
Ubl_MoaD_like cd17040
ubiquitin-like (Ubl) domain found in a group of small sulfide carrier proteins; Ubiquitin-like ...
 206-287 1.48e-09

ubiquitin-like (Ubl) domain found in a group of small sulfide carrier proteins; Ubiquitin-like (Ubl) domain found in a group of small sulfide carrier proteins This family includes ThiS, MoaD, CysO, QbsE, and their homologs, which are structurally homologous to ubiquitin (Ub) and may function as the sulfide donor for the biosynthesis of thiamin, molybdopterin, cysteine, thioquinolobactin, and other sulfur-containing natural products. Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Ubiquitination is comprised of a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C-terminus of Ub and the epsilon-amino group of a substrate lysine. Like Ub, small sulfide carrier proteins in this family are adenylated at a diglycyl C-terminus by specific activating proteins. The adenylated C-terminus is subsequently converted to a thiocarboxylate, serving as the sulfide source. Those activating proteins are diverse and show little sequence similarity. This family also includes the small archaeal modifier protein (SAMP), including SAMP1, SAMP2 and SAMP3, which are Ub-like proteins that function as protein modifiers and are required for the production of sulfur-containing biomolecules in the archaeon Haloferax volcanii. SAMP1 and SAMP2 are involved in sulfur transfer during molybdenum cofactor biosynthesis and tRNA thiolation much like MoaD and Urm1, respectively. They can form covalent conjugates with their protein targets through an isopeptide linkage via their C-terminal diglycine motif in a streamlined archaeal E1-dependent pathway. SAMP2 also forms homo-conjugates through the intermolecular isopeptide bond between the C-terminal Gly and the Lys58 side chain, a feature that likely resembles polyubiquitination. SAMP3 conjugates are dependent on the Ub-activating E1 enzyme homolog of archaea (UbaA) for synthesis and are cleaved by the JAMM/MPN+ domain metalloprotease HvJAMM1.


Pssm-ID: 340560 [Multi-domain]  Cd Length: 88  Bit Score: 53.92  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDslaLNLTTLSEATVGGLKRTLALRDPQLEALNDT------RVLCAVNQDMVRDDH---PLNAGD 276
Cdd:cd17040     1 VKVRLFGALREAGAGE---EEIEVEGGTTVRDLLDALSERYPGLFEALDEdgelrpFILVFVNGRDVRLDDgltPLKDGD 77

                          90
                  ....*....|.
gi 2738573402 277 EVAFFPPVTGG 287
Cdd:cd17040    78 EVDILPPVAGG 88
PLN02799 PLN02799
Molybdopterin synthase sulfur carrier subunit
 206-287 4.07e-09

Molybdopterin synthase sulfur carrier subunit


Pssm-ID: 215429  Cd Length: 82  Bit Score: 52.32  E-value: 4.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTtlSEATVGGLKRTLALRDPQLEALNDTRVLcAVNQDMVRDDHPLNAGDEVAFFPPVT 285
Cdd:PLN02799    4 IKVLFFARARELTGVSDMTLELP--AGSTTADCLAELVAKFPSLEEVRSCCVL-ALNEEYTTESAALKDGDELAIIPPIS 80


                  ..
gi 2738573402 286 GG 287
Cdd:PLN02799   81 GG 82
moaD_arch TIGR01687
MoaD family protein, archaeal; Members of this family appear to be archaeal versions of MoaD, ...
 206-287 2.51e-05

MoaD family protein, archaeal; Members of this family appear to be archaeal versions of MoaD, subunit 1 of molybdopterin converting factor. This model has been split from the bacterial/eukaryotic equivalog model TIGR01682 because the presence of two members of this family in a substantial number of archaeal species suggests that roles might not be interchangeable. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 273758  Cd Length: 88  Bit Score: 42.04  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLttlSEATVGGLKRTLALRDPQL-------EALNDTRVLCAVNQDMVR--DDHPLNAGD 276
Cdd:TIGR01687   1 VRVKYFATLRDITGKKSEEIEI---EGKTVGDLLNELMARYPKEfselfkeGLGLVPNVIILVNGRNVDwgLGTELKDGD 77

                          90
                  ....*....|.
gi 2738573402 277 EVAFFPPVTGG 287
Cdd:TIGR01687  78 VVAIFPPVSGG 88
Ubl_SAMP1_like cd17505
ubiquitin-like (Ubl) domain found in small archaeal modifier protein 1 (SAMP1); Ubiquitin-like ...
 206-287 7.49e-05

ubiquitin-like (Ubl) domain found in small archaeal modifier protein 1 (SAMP1); Ubiquitin-like small archaeal modifier protein 1 (SAMP1) shows a beta-grasp fold of Ub, suggesting that this archaeal Ubl molecule is more closely related to eukaryotic Ub and Ubls than to its prokaryotic counterpart. Several Ub-like structural features such as an N-terminal single lysine residue and di-glycine motif at the C-terminus, spatially isolated, implicate formation of a poly-SAMPylated chainpoly-SAMPylation. SAMP1 can form covalent conjugates with its protein targets through an isopeptide linkage via their C-terminal diglycine motif in a streamlined archaeal E1-dependent pathway. It is involved in sulfur transfer during molybdenum cofactor biosynthesis much like MoaD. This family also includes proteins such as Thermoplasma acidophilum TA0895 and others, all closely related to proteins MoaD.


Pssm-ID: 340762  Cd Length: 90  Bit Score: 40.80  E-value: 7.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2738573402 206 VRVLFLAELRERLDLDSLALNLTtlsEATVGGLKRTL-----ALRDPQLEALND--TRVLCAVNQDMVR----DDHPLNA 274
Cdd:cd17505     1 VEVKLYATLREVAGSKEVELDVD---GATVGEVLDSLvalypALEGRLITEDGElaEHVIVLVNGRNIRhlegLETPLKD 77

                          90
                  ....*....|...
gi 2738573402 275 GDEVAFFPPVTGG 287
Cdd:cd17505    78 GDTIDLFPPVAGG 90
ThiS COG2104
Sulfur carrier protein ThiS (thiamine biosynthesis) [Coenzyme transport and metabolism]; ...
 252-287 5.25e-04

Sulfur carrier protein ThiS (thiamine biosynthesis) [Coenzyme transport and metabolism]; Sulfur carrier protein ThiS (thiamine biosynthesis) is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 441707 [Multi-domain]  Cd Length: 66  Bit Score: 37.75  E-value: 5.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2738573402 252 LNDTRVLCAVNQDMV----RDDHPLNAGDEVAFFPPVTGG 287
Cdd:COG2104    27 LDPKGVAVAVNGEIVprsqWASTVLKEGDRVEIVTAVGGG 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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