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Conserved domains on  [gi|2743938595|ref|WP_349675139|]
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methyltransferase domain-containing protein [Carnobacterium sp. 1290_CSPC]

Protein Classification

class I SAM-dependent RNA methyltransferase( domain architecture ID 1903519)

class I SAM-dependent RNA methyltransferase catalyzes the methylation of a specific RNA substrate using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:1904047
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmA super family cl43665
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 1-76 1.62e-27

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG2265:

Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 101.79  E-value: 1.62e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2743938595   1 MDAADLIGEETVVDGYCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAETVMGEWVKAG 76
Cdd:COG2265   226 LEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELLWGG 301
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 1-76 1.62e-27

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 101.79  E-value: 1.62e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2743938595   1 MDAADLIGEETVVDGYCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAETVMGEWVKAG 76
Cdd:COG2265   226 LEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELLWGG 301
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 1-77 2.12e-24

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 93.73  E-value: 2.12e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2743938595   1 MDAADLIGEETVVDGYCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAETVMGEWVKAGI 77
Cdd:TIGR00479 285 LEWLELQGEERVLDAYCGMGTFTLPLAKQAKSVVGVEGVPESVEKAQQNAELNGIANVTFYHGTLETVLPKQPWAGN 361
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
9-60 4.14e-12

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 59.40  E-value: 4.14e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2743938595   9 EETVVDGYCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHF 60
Cdd:PRK13168  298 GDRVLDLFCGLGNFTLPLARQAAEVVGVEGVEAMVERARENARRNGLDNVTF 349
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 16-66 1.22e-06

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 43.97  E-value: 1.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2743938595  16 YCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAE 66
Cdd:pfam05958 209 YCGNGNFSLALARNFRKVLATEIAKPSVAAAQYNIAANNIDNVQIIRMSAE 259
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 11-68 1.54e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 39.34  E-value: 1.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2743938595  11 TVVDGYCGIGTITLALA-NKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAETV 68
Cdd:cd02440     1 RVLDLGCGTGALALALAsGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL 59
rADc smart00650
Ribosomal RNA adenine dimethylases;
1-38 1.52e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 34.79  E-value: 1.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2743938595    1 MDAADLIGEETVVDGYCGIGTITLALANKAKQVYGVEV 38
Cdd:smart00650   6 VRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEI 43
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 1-76 1.62e-27

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 101.79  E-value: 1.62e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2743938595   1 MDAADLIGEETVVDGYCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAETVMGEWVKAG 76
Cdd:COG2265   226 LEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELLWGG 301
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 1-77 2.12e-24

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 93.73  E-value: 2.12e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2743938595   1 MDAADLIGEETVVDGYCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAETVMGEWVKAGI 77
Cdd:TIGR00479 285 LEWLELQGEERVLDAYCGMGTFTLPLAKQAKSVVGVEGVPESVEKAQQNAELNGIANVTFYHGTLETVLPKQPWAGN 361
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
9-60 4.14e-12

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 59.40  E-value: 4.14e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2743938595   9 EETVVDGYCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHF 60
Cdd:PRK13168  298 GDRVLDLFCGLGNFTLPLARQAAEVVGVEGVEAMVERARENARRNGLDNVTF 349
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
3-65 3.25e-07

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 45.24  E-value: 3.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2743938595   3 AADLIGE---ETVVDGYCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQA 65
Cdd:PRK03522  165 ARDWVRElppRSMWDLFCGVGGFGLHCATPGMQLTGIEISAEAIACAKQSAAELGLTNVQFQALDS 230
PRK05031 PRK05031
tRNA (uracil-5-)-methyltransferase; Validated
 16-60 4.98e-07

tRNA (uracil-5-)-methyltransferase; Validated


Pssm-ID: 235332  Cd Length: 362  Bit Score: 44.82  E-value: 4.98e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2743938595  16 YCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHF 60
Cdd:PRK05031  214 YCGNGNFTLALARNFRRVLATEISKPSVAAAQYNIAANGIDNVQI 258
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 2-60 7.94e-07

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 44.38  E-value: 7.94e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2743938595   2 DAADLIGEETVVDgycgIGT------ITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHF 60
Cdd:PRK09328  102 EALLLKEPLRVLD----LGTgsgaiaLALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEF 162
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 11-63 1.21e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 43.37  E-value: 1.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2743938595  11 TVVDGYCGIGTITLALANKAK-QVYGVEVVGGAVKMAKNNAAKNYIDNVHFETG 63
Cdd:COG0500    29 RVLDLGCGTGRNLLALAARFGgRVIGIDLSPEAIALARARAAKAGLGNVEFLVA 82
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 16-66 1.22e-06

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 43.97  E-value: 1.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2743938595  16 YCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAE 66
Cdd:pfam05958 209 YCGNGNFSLALARNFRKVLATEIAKPSVAAAQYNIAANNIDNVQIIRMSAE 259
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 1-60 7.06e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 41.33  E-value: 7.06e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2743938595   1 MDAADLIGEETVVD-GyCGIGTI--TLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHF 60
Cdd:COG2813    42 LEHLPEPLGGRVLDlG-CGYGVIglALAKRNPEARVTLVDVNARAVELARANAAANGLENVEV 103
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 11-66 9.24e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 40.48  E-value: 9.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2743938595  11 TVVDGYCGIGTITLALANKA---KQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAE 66
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELgpnAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIE 64
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 11-68 1.54e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 39.34  E-value: 1.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2743938595  11 TVVDGYCGIGTITLALA-NKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAETV 68
Cdd:cd02440     1 RVLDLGCGTGALALALAsGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL 59
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 1-66 1.55e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 39.98  E-value: 1.55e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2743938595   1 MDAADLIGEETVVD-GyCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIdNVHFETGQAE 66
Cdd:COG2226    15 LAALGLRPGARVLDlG-CGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAE 79
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 2-53 3.15e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 39.74  E-value: 3.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2743938595   2 DAADLIGEETVVDGYCGIGTITLALA--NKAKQVYGVEVVGGAVKMAKNNAAKN 53
Cdd:COG4123    31 AFAPVKKGGRVLDLGTGTGVIALMLAqrSPGARITGVEIQPEAAELARRNVALN 84
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 2-38 4.78e-05

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 39.34  E-value: 4.78e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2743938595   2 DAADLIGEETVVDGYCGIGTITLALANKAKQVYGVEV 38
Cdd:COG0030    31 DAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEI 67
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 4-53 6.12e-05

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 39.07  E-value: 6.12e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2743938595   4 ADLIGE-ETVVDGYCGIGTITLALA-NKAKQVYGVEVVGGAVKMAKNNAAKN 53
Cdd:COG2520   175 AELVKPgERVLDMFAGVGPFSIPIAkRSGAKVVAIDINPDAVEYLKENIRLN 226
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 17-66 6.16e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 37.54  E-value: 6.16e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 2743938595 17 CGIGTITLALANKAK-QVYGVEVVGGAVKMAKNNAAKNYIdNVHFETGQAE 66
Cdd:pfam13649  6 CGTGRLTLALARRGGaRVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAE 55
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
11-60 6.38e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 38.86  E-value: 6.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2743938595  11 TVVDGYCGIGTIT-LALANKAKQVYGVEVVGGAVKMAKNNAAKN-YIDNVHF 60
Cdd:COG4076    38 VVLDIGTGSGLLSmLAARAGAKKVYAVEVNPDIAAVARRIIAANgLSDRITV 89
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 17-68 1.28e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 37.30  E-value: 1.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2743938595  17 CGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNyidNVHFETGQAETV 68
Cdd:COG2227    33 CGTGRLALALARRGADVTGVDISPEALEIARERAAEL---NVDFVQGDLEDL 81
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 17-59 6.14e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 34.95  E-value: 6.14e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 2743938595 17 CGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVH 59
Cdd:pfam08241  5 CGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVV 47
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 10-68 1.15e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 35.31  E-value: 1.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2743938595  10 ETVVDGYCGIGTITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNVHFETGQAETV 68
Cdd:COG1041    28 DTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDL 86
rADc smart00650
Ribosomal RNA adenine dimethylases;
1-38 1.52e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 34.79  E-value: 1.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2743938595    1 MDAADLIGEETVVDGYCGIGTITLALANKAKQVYGVEV 38
Cdd:smart00650   6 VRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEI 43
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 10-58 1.84e-03

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 34.64  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2743938595  10 ETVVDGYCGIG--TITLALANKAKQVYGVEVVGGAVKMAKNNAAKNYIDNV 58
Cdd:pfam02475 101 EVVVDMFAGIGpfSIPIAKHSKARRVYAIELNPESYKYLKENIKLNKVEDV 151
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
3-60 4.69e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 33.72  E-value: 4.69e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2743938595   3 AADLIG---EETVVDGYCGIGTITLALANK-AKQVYGVEVVGGAVKMAKNNaAKNYIDNVHF 60
Cdd:COG2263    37 LAYLRGdieGKTVLDLGCGTGMLAIGAALLgAKKVVGVDIDPEALEIAREN-AERLGVRVDF 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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