|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-804 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1606.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 1 MSFDHQTIEKKWQDYWLKNKTFATREDKSKPKFYALDMFPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDA 80
Cdd:COG0495 3 ERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 81 FGLPAEQYALDTGNDPAVFTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA 160
Cdd:COG0495 82 FGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 161 LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELD-WPESIKEMQRNWIGRSEGAHVHFAVDGTNE 239
Cdd:COG0495 162 DQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVEGSDE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 240 TFTVFTTRPDTLFGATYAVLAPEHDLVQKITMPEQKDAVNAYIEEVQSKSDLERTDLAKTKTGVFTGAYAVNPANGEKIP 319
Cdd:COG0495 242 KITVFTTRPDTLFGATFMVLAPEHPLVKELATPEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEKIP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 320 VWIADYVLATYGTGAVMAVPAHDERDHEFASAFGLPIKEVVKGGDVE-----KEAYTGDGEHIHSDFLNGLDKAAAIEKM 394
Cdd:COG0495 322 IWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDdpdilEEAYTGDGVLINSGEFDGLDSEEAKEAI 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 395 IQWLEENGKGEKKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTPVPEEELPLILPKTSEIKPsgTGESPLANIKEWVEV 474
Cdd:COG0495 402 IEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDP--TGGSPLARAPEWVNV 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 475 TDPETGKKGRRETNTMPQWAGSCWYFLRYIDPKNPNELASPEKLKEWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVV 554
Cdd:COG0495 480 TCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLV 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 555 PTKEPFKQLYNQGMI--LGENN------EKMSKSKGNVVNPDEIVETHGADTLRLYEMFMGPLDASIAWSTTGLDGARRF 626
Cdd:COG0495 560 SFDEPFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRF 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 627 LDRVWRLFIDDNGGLNEKIVEGAGET--LERVYHETVMKVTDHFEGLRFNTGISQLMVFINEAYKADQ-------LPKEY 697
Cdd:COG0495 640 LNRVWRLVVDEAEALKLDVADLSEADkeLRRALHKTIKKVTEDIERLRFNTAIAALMELVNALYKAKDsgeadraVLREA 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 698 MEGFVKLLSPVAPHLAEELWNRLGHEETIAYEAWPVYDEAKLVDDEIEIVVQLNGKVKAKLNVPADADKEQLEELAKNNE 777
Cdd:COG0495 720 LETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEADEAALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADE 799
|
810 820
....*....|....*....|....*..
gi 2747046742 778 KVKEQLEGKTIRKVIAVPGKLVNIVAN 804
Cdd:COG0495 800 KVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
3-804 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1348.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 3 FDHQTIEKKWQDYWLKNKTFATREDKSKPKFYALDMFPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFG 82
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGA-LHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 83 LPAEQYALDTGNDPAVFTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCPALG 162
Cdd:TIGR00396 80 LPAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 163 TVLANEEVI-DGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELD-WPESIKEMQRNWIGRSEGAHVHFAVDGTNET 240
Cdd:TIGR00396 160 TVLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKIADHDEK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 241 FTVFTTRPDTLFGATYAVLAPEHDLVQKITMPEQKdaVNAYIEEVQSKSDLERTDLAKTKTGVFTGAYAVNPANGEKIPV 320
Cdd:TIGR00396 240 ITVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPK--VAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIPI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 321 WIADYVLATYGTGAVMAVPAHDERDHEFASAFGLPIKEVVKGGD---VEKEAYTGDGEHIHSDFLNGLDKAAAIEKMIQW 397
Cdd:TIGR00396 318 WVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEkdlSLTAAYTEDGVLVNSGEFNGLNSSEARNAIIDM 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 398 LEENGKGEKKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTPVPEEELPLILPKTSEIKPSgtGESPLANIKEWVEVTDP 477
Cdd:TIGR00396 398 LEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGD--GGSPLSRIPEWVNVTCP 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 478 ETGKKGRRETNTMPQWAGSCWYFLRYIDPKNPNELASPEKLKEWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTK 557
Cdd:TIGR00396 476 SCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTK 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 558 EPFKQLYNQGMILG----ENNE---------------------------KMSKSKGNVVNPDEIVETHGADTLRLYEMFM 606
Cdd:TIGR00396 556 EPFKKLINQGMVLGfyypPNGKvpadvlterdekgkdkaggelvyvgyeKMSKSKGNGIDPQEIVESYGADALRLFIMFM 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 607 GPLDASIAWSTTGLDGARRFLDRVWRLFIDDNG-----GLNEKIVEGAGETLERVYHETVMKVTDHFEGLR-FNTGISQL 680
Cdd:TIGR00396 636 GPIAASLEWNESGLEGARRFLDRVWNLVYEITGeldaaSLTVTALEEAQKELRRDVHKFLKKVTEDLEKREsFNTAISAM 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 681 MVFINEAYKA--DQLPKEYMEGFVKLLSPVAPHLAEELWNRLGHEETIAYEA-WPVYDEAKLVDDEIEIVVQLNGKVKAK 757
Cdd:TIGR00396 716 MELLNKLYKAkkEALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFIIDNAkWPVVDETALVEDKTLIVVQVNGKFRAK 795
|
810 820 830 840
....*....|....*....|....*....|....*....|....*..
gi 2747046742 758 LNVPADADKEQLEELAKNNEKVKEQLEGKTIRKVIAVPGKLVNIVAN 804
Cdd:TIGR00396 796 ITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
7-803 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 1331.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 7 TIEKKWQDYWLKNKTFATRE--DKSKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLP 84
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRTPDdvDTSKPKFYVLDMFPYPSGAGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 85 AEQYALDTGNDPAVFTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCPALGTV 164
Cdd:PLN02563 164 AEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTV 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 165 LANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKEMQRNWIGRSEGAHVHFAVDG-----TNE 239
Cdd:PLN02563 244 LANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVLDgegkeRDE 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 240 TFTVFTTRPDTLFGATYAVLAPEHDLVQKITMPEQKDAVNAYIEEVQSKSDLERTDLAKTKTGVFTGAYAVNPANGEKIP 319
Cdd:PLN02563 324 KITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERTELQKEKTGVFTGSYAINPATGEAIP 403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 320 VWIADYVLATYGTGAVMAVPAHDERDHEFASAFGLPIKEVVK---GGDVEKE-AYTGDGEHIHS-----DFlNGLDKAAA 390
Cdd:PLN02563 404 IWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKpadGNEDDAEkAYTGEGVIVNSsssglDI-NGLSSKEA 482
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 391 IEKMIQWLEENGKGEKKVTYRLRDWLFSRQRYWGEPIPIIHWED-GTSTPVPEEELPLILPKTSEIKPSGTGESPLANIK 469
Cdd:PLN02563 483 AKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDsGEPVPVPESDLPLTLPELDDFTPTGTGEPPLAKAV 562
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 470 EWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPKNPNELASPEKLKEWLPVDMYIGGAEHAVLHLLYARFWHKFLY 549
Cdd:PLN02563 563 SWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLY 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 550 DIGVVPTKEPFKQLYNQGMILGE------------------------------------------------------NNE 575
Cdd:PLN02563 643 DIGVVSTKEPFQCLVNQGMILGEveytafkdsdgeyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliaRAH 722
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 576 KMSKSKGNVVNPDEIVETHGADTLRLYEMFMGPLDASIAWSTTGLDGARRFLDRVWRLFIDD---NGGLNEKIVEGAGE- 651
Cdd:PLN02563 723 KMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVGAplpDGSFRDGTVVTDEEp 802
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 652 TLE--RVYHETVMKVTDHFEGLRFNTGISQLMVFINEAYKADQLPKEYMEGFVKLLSPVAPHLAEELWNRLGHEETIAYE 729
Cdd:PLN02563 803 SLEqlRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKWDKVPREAIEPFVLLLSPYAPHLAEELWFRLGHSNSLAYE 882
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2747046742 730 AWPVYDEAKLVDDEIEIVVQLNGKVKAKLNVPADADKEQLEELAKNNEKVKEQLEGKTIRKVIAVPGKLVNIVA 803
Cdd:PLN02563 883 PWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVPGKILNVIL 956
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
32-615 |
1.86e-126 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 380.83 E-value: 1.86e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 32 KFYALDMFPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAVFTEQNIDNFRRQI 111
Cdd:cd00812 1 KFYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 112 RALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCpalgtvlaneevidgksergghpverRPMKQWM 191
Cdd:cd00812 80 KRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWF 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 192 LKI--TAYADRLLEDLeeldwpesikemqrnwigrsegahvhfavdgtnetftvfttrpdtlfgatyavlapehdlvqki 269
Cdd:cd00812 134 LKYseTEWKEKLLKDL---------------------------------------------------------------- 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 270 tmpeqkdavnayieevqsksdlertdlaktktgvftgayavnpangEKIPVWiadyvlatygtgavmavpahderdhefa 349
Cdd:cd00812 150 ----------------------------------------------EKLDGW---------------------------- 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 350 safglpiKEVVKGGdvekeaytgdgehihsdflngldkaaaiekmiqwleengkgekkvtyrLRDWL-FSRQRYWGEPIP 428
Cdd:cd00812 156 -------PEEVRAM------------------------------------------------QENWIgCSRQRYWGTPIP 180
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 429 IihwedgtstpvpeeelplilpktseikpsgtgesplanikewvevtdpetgkkgrreTNTMPQWAGSCWYFLRYIDPKN 508
Cdd:cd00812 181 W---------------------------------------------------------TDTMESLSDSTWYYARYTDAHN 203
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 509 PNEL------ASPEKLKEWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVpTKEPFKQLYNQGMILGeNNEKMSKSKG 582
Cdd:cd00812 204 LEQPyegdleFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLL-EGEKMSKSKG 281
|
570 580 590
....*....|....*....|....*....|...
gi 2747046742 583 NVVNPDEIVETHGADTLRLYEMFMGPLDASIAW 615
Cdd:cd00812 282 NVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
3-784 |
7.07e-93 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 310.07 E-value: 7.07e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 3 FDHQTIEKKWQDYWLKNKTFATREDKSKPKFYALDMFPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFG 82
Cdd:TIGR00422 5 YDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGS-LHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 83 LPAE-----QYAL------DTGNDPAV-----FTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKG 146
Cdd:TIGR00422 84 IATQvkvekKLGAegktkhDLGREEFRekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 147 LAYVDEVPVNWCPALGTVLANEEvidgksergghpVERRPMKQWMLKItayadrlledleeldwpesikemqrnwigrse 226
Cdd:TIGR00422 164 LIYRGEYLVNWDPKLNTAISDIE------------VEYKEVKGKLYYI-------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 227 gahVHFAVDGTNETFTVFTTRPDTLFGATyAVlapehdlvqkitmpeqkdAVNAYIEEVQSksdlertdlaktktgvFTG 306
Cdd:TIGR00422 200 ---RYPLANGSKDYLVVATTRPETMFGDT-AV------------------AVHPEDERYKH----------------LIG 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 307 AYAVNPANGEKIPVwIAD-YVLATYGTGAVMAVPAHDERDHEFASAFGLPIKEVV-KGGDVEKEAytgdgehihSDFlNG 384
Cdd:TIGR00422 242 KKVILPLTGRKIPI-IADeYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILdEDGLLNENA---------GKY-QG 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 385 LDKAAAIEKMIQWLEENGKGEKKVTYR----------------------------------------------------- 411
Cdd:TIGR00422 311 LTRFEARKKIVEDLKEEGLLVKIEPHThnvgtcwrsgtvvepllskqwfvkvekladkaleaaeegeikfvpkrmekryl 390
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 412 -----LRDWLFSRQRYWGEPIPIIHWEDGTSTPVPEEELPlilpktsEIKPSGTGESplaniKEWvevtdpetgkkgRRE 486
Cdd:TIGR00422 391 nwlrnIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEPL-------PDDKTNTGPS-----VEL------------EQD 446
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 487 TNTMPQW-AGSCWYFLRYIDPKNPNElaspekLKEWLPVDMYIGGaeHAVLhllyaRFWHKFLYDIGVVPTKE-PFKQLY 564
Cdd:TIGR00422 447 TDVLDTWfSSSLWPFSTLGWPDETKD------LKKFYPTDLLVTG--YDII-----FFWVARMIFRSLALTGQvPFKEVY 513
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 565 NQGMILGENNEKMSKSKGNVVNPDEIVETHGADTLRLYEMFMGPLDASIAWSTTGLDGARRFLDRVWRLF------IDDN 638
Cdd:TIGR00422 514 IHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWNASrfvlmnLSDD 593
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 639 GGLN--EKIVEGAGETLERVYHETVMKVTDHFEGLRFNTGISQLMVFI-------------------NEAYK--ADQLPK 695
Cdd:TIGR00422 594 LELSggEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIwndfcdwyielvkyrlyngNEAEKkaARDTLY 673
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 696 EYMEGFVKLLSPVAPHLAEELWNRLGH-EETIAYEAWPVYDE-------AKLVDDEIEIVVQLNgKVKAKLNVPADADKE 767
Cdd:TIGR00422 674 YVLDKALRLLHPFMPFITEEIWQHFKEgADSIMLQSYPVVDAefvdeeaEKAFELLKEIIVSIR-NLKAESNIPPNAPLK 752
|
890
....*....|....*....
gi 2747046742 768 QLE--ELAKNNEKVKEQLE 784
Cdd:TIGR00422 753 VLLiyTEAETAERLKLNAV 771
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
219-399 |
5.48e-92 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 286.36 E-value: 5.48e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 219 RNWIGRSEGAHVHFAVDGTNETFTVFTTRPDTLFGATYAVLAPEHDLVQKItmPEQKDAVNAYIEEVQSKSDLERTDLAK 298
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKL--AEKNPEVAAFIEECKNTSEIERTSETK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 299 TKTGVFTGAYAVNPANGEKIPVWIADYVLATYGTGAVMAVPAHDERDHEFASAFGLPIKEVVKGGDVE------KEAYTG 372
Cdd:pfam13603 79 EKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGDldldimTEAYTE 158
|
170 180
....*....|....*....|....*..
gi 2747046742 373 DGEHIHSDFLNGLDKAAAIEKMIQWLE 399
Cdd:pfam13603 159 EGILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
4-774 |
1.62e-80 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 275.15 E-value: 1.62e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 4 DHQTIEKKWQDYWLKNKTFATREDKSKPKfYALDMFP-YPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFG 82
Cdd:PRK13208 11 DPEELEEKWQKIWEEEGTYKFDPDERKPV-YSIDTPPpTVSGS-LHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDNG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 83 LPAEQYALDTGN------DPAVF-------TEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAY 149
Cdd:PRK13208 89 LPTERKVEKYYGirkddiSREEFielcrelTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLIY 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 150 VDEVPVNWCPALGTVLANEEVidgksergghpverrpmkqwmlkitayadrllEDLEEldwpesikemqrnwigrsEGA- 228
Cdd:PRK13208 169 RAEAPVLWCPRCETAIAQAEV--------------------------------EYRER------------------EGKl 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 229 -HVHFAVdGTNETFTVFTTRPDtLFGATYAVLApeHdlvqkitmPEqkDavnayieevqsksdlER-TDLAktktgvftG 306
Cdd:PRK13208 199 nYIKFPV-EDGEEIEIATTRPE-LLPACVAVVV--H--------PD--D---------------ERyKHLV--------G 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 307 AYAVNPANGEKIPVwIAD-YVLATYGTGAVMAVPAHDERDHEFASAFGLPIKEVV-KGGDVeKEAYtgdgehihsDFLNG 384
Cdd:PRK13208 242 KTAIVPLFGVEVPI-LADpLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIdEDGRM-TEAA---------GKLAG 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 385 LDKAAAIEKMIQWLEENG----------------KGEK------------KVT-------------------YRLR---- 413
Cdd:PRK13208 311 LTIEEARKKIVEDLKSGGllgkqepikhnvkfceRCDTpleilvtrqwfiKVLdlkeellergkeinwypehMRVRlenw 390
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 414 ------DWLFSRQRYWGEPIPIIHWEDGTSTPVPEEE-LPlILPkTSEiKPSGTgesplanikewvevTDPETGKKG-RR 485
Cdd:PRK13208 391 ieglnwDWCISRQRYFGTPIPVWYCKDCGHPILPDEEdLP-VDP-TKD-EPPGY--------------KCPQCGSPGfEG 453
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 486 ETNTMPQWAGSC---WYFLRYIDPKNPNELASPEKLKE--------WLpvdmYiggaeHAVL--HLLYArfwhkflydig 552
Cdd:PRK13208 454 ETDVMDTWATSSitpLIVTGWERDEDLFEKVFPMDLRPqghdiirtWL----F-----YTILraYLLTG----------- 513
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 553 vvptKEPFKQLYNQGMILGENNEKMSKSKGNVVNPDEIVETHGADTLRlYEMFMGPLDASIAWSTTGLDGARRFLDRVWR 632
Cdd:PRK13208 514 ----KLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVR-YWAASARLGSDTPFDEKQVKIGRRLLTKLWN 588
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 633 L--FIDDNGGLNEKIVEGAGETLER----VYHETVMKVTDHFEGLRFNTGISQLMVFI-----------------NEAYK 689
Cdd:PRK13208 589 AsrFVLHFSADPEPDKAEVLEPLDRwilaKLAKVVEKATEALENYDFAKALEEIESFFwhvfcddylelvksrayGEDEE 668
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 690 ADQLPKEY-----MEGFVKLLSPVAPHLAEELWNRLgHEETIAYEAWPVYDEAkLVDDEI----EIVVQLNGKV------ 754
Cdd:PRK13208 669 EEQKSARYtlytvLDTLLRLLAPFLPFITEEVWSWL-YGGSVHRASWPEPDEE-LIDEEDeelgELAKEILSAVrkykse 746
|
890 900
....*....|....*....|....*...
gi 2747046742 755 -KAKLNVP-------ADADKEQLEELAK 774
Cdd:PRK13208 747 aGLSLNAPlkkvevyGPADLELLEAAEE 774
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
11-616 |
9.02e-66 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 230.37 E-value: 9.02e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 11 KWQDYWLKNKTF--ATREDKSKPKFYALDMFPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQ- 87
Cdd:pfam00133 1 QIYEFWDEQGYFkpELEKRKGKPSFTIHDGPPNATGS-LHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQv 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 88 ----YALDTGNDPAVFTEQNIDNF------------RRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYVD 151
Cdd:pfam00133 80 vekkLGIKEKKTRHKYGREEFREKcrewkmeyadeiRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 152 EVPVNWCPALGTVLANEEVIdgksergghpverrpmkqwmlkitaYADrlledleeldwpesikemqrnwigrSEGAHVH 231
Cdd:pfam00133 160 KKLVNWSPALNTALSNLEVE-------------------------YKD-------------------------VKGPSIH 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 232 FA---VDGTNETFTVFTTRPDTLFGATYAVLAPEHDLVqkiTMPEQKDAVNAYIEEVQSKSDlERTDLAKTKTGVFTGAY 308
Cdd:pfam00133 190 VAfplADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYV---ITGEGYILAEALLKSLYKKGT-DKKILEDFRGKELEGKE 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 309 AVNPANGEKIPVWIADYVLATYGTGAVMAVPAHDERDHEFASAFGLP-IKEVVKGGDVEKEAytgdgehihSDFlNGLDK 387
Cdd:pfam00133 266 AIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEvINPVDDDGTFTEEA---------PDF-QGVYR 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 388 AAAIEKMIQWLEENG----------------KGEKKVTYRL--------------------------------------- 412
Cdd:pfam00133 336 FDARKKIVELLTEKGlllkiepfthsypfcwRSGTPIIPRAtpqwfvrmdeladqaleavekvqfvpksgekryfnwlan 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 413 -RDWLFSRQRYWGEPIPIIHWEDGtstpvpeEELPLILPKTSEIKPSGTGEsplANIKEW-VEVTDPETGKKG--RRETN 488
Cdd:pfam00133 416 iQDWCISRQRWWGHPIPAWVSKDT-------EEVVCRGELFELVAGRFEEE---GSIKWLhREAKDKLGYGKGtlEQDED 485
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 489 TMPQW--AGScWYF--LRYidpknPNELAspEKLKEWLPVDMYIGGAEHavlhllyARFWHKFLYDIGVVPTKE-PFKQL 563
Cdd:pfam00133 486 VLDTWfsSGS-WPFstLGW-----PFVNT--EEFKKFFPADMLLEGSDQ-------TRGWFYRMIMLSTALTGSvPFKNV 550
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 2747046742 564 YNQGMILGENNEKMSKSKGNVVNPDEIVETHGADTLRLYeMFMGPLDASIAWS 616
Cdd:pfam00133 551 LVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLW-LANSDYGRDINLS 602
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
2-780 |
7.21e-63 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 227.30 E-value: 7.21e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 2 SFDHQTIEKKWQDYWLKNKTFATREDKSKPkfYALdMFPYPSGAG-LHVGHpeGYTAT--DILSRMKRMQGYNVL----- 73
Cdd:PRK05729 8 TYDPKEVEAKWYQKWEEKGYFKPDDNSKKP--FSI-VIPPPNVTGsLHMGH--ALNNTlqDILIRYKRMQGYNTLwlpgt 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 74 ----------------------HPMGWDAFglpaeqyaLDtgndpAVF--TEQNIDNFRRQIRALGFSYDWDREVNTTDP 129
Cdd:PRK05729 83 dhagiatqmvverqlaaegksrHDLGREKF--------LE-----KVWewKEESGGTITNQLRRLGASCDWSRERFTMDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 130 DYYKWTQWIFLKLYEKGLAYVDEVPVNWCPALGTVLANEEVidgksergghpvERRPMKQWMlkitayadrlledleeld 209
Cdd:PRK05729 150 GLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV------------EYKEVKGKL------------------ 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 210 wpesikemqrnWigrsegaHVHFAVDGTNETFTVFTTRPDTLFGATyAVlapehdlvqkitmpeqkdAVNAyieevqskS 289
Cdd:PRK05729 200 -----------W-------HIRYPLADGSDYLVVATTRPETMLGDT-AV------------------AVNP--------E 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 290 DlER-TDLAktktgvftGAYAVNPANGEKIPVwIAD-YVLATYGTGAVMAVPAHDERDHEFASAFGLPIKEVVkggdvek 367
Cdd:PRK05729 235 D-ERyKHLI--------GKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIM------- 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 368 eayTGDGeHI--HSDFLNGLDKAAAIEKMIQWLEENG------------------------------------------- 402
Cdd:PRK05729 298 ---DEDG-TIneNPGEYQGLDRFEARKAIVADLEELGllvkiephthsvghsdrsgvviepylsdqwfvkmkplakpale 373
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 403 ---KGE--------KKvTYR-----LRDWLFSRQRYWGEPIPIIHWEDGtstpvpeeelplilpktseikpsgtgespla 466
Cdd:PRK05729 374 aveNGEikfvperwEK-TYFhwmenIQDWCISRQLWWGHRIPAWYDEDG------------------------------- 421
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 467 niKEWVEVTDPETGKKG--RRETNTMPQWAGS-CWYF--LryidpKNPNElasPEKLKEWLPVDMYIGGaehavlhllya 541
Cdd:PRK05729 422 --EVYVGREEPEAREKAllTQDEDVLDTWFSSaLWPFstL-----GWPEK---TEDLKRFYPTSVLVTG----------- 480
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 542 rfwhkflYDI-----------GVVPTKE-PFKQLYNQGMILGENNEKMSKSKGNVVNPDEIVETHGADTLRLYEMFMGPL 609
Cdd:PRK05729 481 -------FDIiffwvarmimmGLHFTGQvPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASP 553
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 610 DASIAWSTTGLDGARRFLDRVW---RlFIDDNGGLNEKIVEGAGETLERV-------YHETVMKVTDHFEGLRFNTGISQ 679
Cdd:PRK05729 554 GRDIRFDEERVEGYRNFANKLWnasR-FVLMNLEGADVGELPDPEELSLAdrwilsrLNRTVAEVTEALDKYRFDEAARA 632
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 680 LMVFI-NE------------AYKADQLPKEYMEGFV-----KLLSPVAPHLAEELWNRLGH---EETIAYEAWPVYDEAK 738
Cdd:PRK05729 633 LYEFIwNEfcdwylelakpvLQEAAKRATRATLAYVleqilRLLHPFMPFITEELWQKLAPlgiEESIMLAPWPEADEAI 712
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*..
gi 2747046742 739 LVDDE------IEIVVQLNgKVKAKLNVPA---------DADKEQLEELAKNNEKVK 780
Cdd:PRK05729 713 DEAAEaefewlKELITAIR-NIRAEMNIPPskklplllkGADAEDRARLEANEAYIK 768
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
1-761 |
1.18e-61 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 223.41 E-value: 1.18e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 1 MSFDHQTIEKKWQDYWLKNKTFAT--REDKSKPKFYALDMFPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGW 78
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEKvkKLNKGKPEFIFHDGPPYANGS-IHLGHALNKILKDIILRYKTMQGFNVTRKPGW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 79 DAFGLPAEQYAL--------DTGNDPAV---------FTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLK 141
Cdd:TIGR00392 83 DTHGLPIEHKVEkklgisgkKEISSLEIeefrekcreFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 142 LYEKGLAYVDEVPVNWCPALGTVLANEEVidgksergghpveRRPMKQWMLK-ITAYADRLLEDLEELDwpesikemqrn 220
Cdd:TIGR00392 163 AHEKGLLYRGLKPVYWSPRCRTALAEAEV-------------EYKENYKDVKdPSIYVKFPVKKDKKTY----------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 221 wigrsEGAHVHFAVdgtnetftVFTTRPDTLFGATYAVLAPEHD--LVQKITMPEQKDAVNAYIEEVQSKSDLERTDLAK 298
Cdd:TIGR00392 219 -----LKVKLSSLL--------IWTTTPWTLPSNLAIAVHPDFEyaLVQDNTKVEYFILAKKLVEKLYNKAGSDYEIIKT 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 299 TKTGVFTGAYAVNPANGEK------IPVWI-ADYVLATYGTGAVMAVPAHDERDHEFASAFGLPI--------------- 356
Cdd:TIGR00392 286 FKGSDLEGLEYEHPLYDFVsqlkegAPVVIgGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVlspvdekgvytegvn 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 357 -KEVVKGGDVEKEAYTGDGEHIHSDFLNGL-------------------------------------DKA-AAIEKmIQW 397
Cdd:TIGR00392 366 dFQGRFVKDADKDIIKANKIIIEQLKDKGLllkaekithsyphcwrtktpviyrateqwfiktkdikDQMlEQIKK-VNW 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 398 LEENGKGE-KKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTStpvpeeelplilPKTSEIKPSGTGESPLANIKEWVE--- 473
Cdd:TIGR00392 445 VPEWGEGRfGNWLENRPDWCISRQRYWGIPIPIWYCEDTGE------------PIVVGSIEELIELIELKGIDAWFEdlh 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 474 --VTDPETGKKG-----RRETNTMPQW--AGSCWYFLRYIDPKNpnelaspEKLKEWLPVDMYIGGAEHavlhllyARFW 544
Cdd:TIGR00392 513 rdFLDKITLKSGdggeyRRVPDVLDVWfdSGSMPYASIHYPFEN-------EKFKEVFPADFILEGSDQ-------TRGW 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 545 HKFLYDIGVVPT-KEPFKQLYNQGMILGENNEKMSKSKGNVVNPDEIVETHGADTLRLYeMFMGPLDASIAWSTTGLDGA 623
Cdd:TIGR00392 579 FYSSLAIGTALFgQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLY-VASSDPWEDLRFSDEILKQV 657
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 624 RRFLDRVWRL---FIDDNGGLN-----------EKIVEGAGETLERVyHETVMKVTDHFEGLRFNTGISQLMVFIN---- 685
Cdd:TIGR00392 658 VEKYRKIRWNtyrFLLTYANLDkfdplfnsvavEKFPEEDRWILSRL-NSLVEEVNEALEKYNFHKVLRALQDFIVeels 736
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 686 -------------EAYKADQLPKEY-----MEGFVKLLSPVAPHLAEELWNRL---GHEETIAYEAWPVYDEA------- 737
Cdd:TIGR00392 737 nwyiriirdrlycEAKDNDKRAAQTtlyyaLLTLVRLLAPFLPHTAEEIYQNLpggEEEESVHLNLWPEVDEEfideale 816
|
890 900
....*....|....*....|....*..
gi 2747046742 738 ---KLVDDEIEIVVQLNGKVKAKLNVP 761
Cdd:TIGR00392 817 anmAIVREIVEAFLALRDAANKKLRQP 843
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
47-800 |
7.97e-59 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 215.89 E-value: 7.97e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 47 LHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLP----AEQYA--------------------LDTGNDPA----V 98
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERIArgdpetielykslygipeeeLEKFKDPEyiveY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 99 FTEQNIDNFRRqiraLGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCPalgtvlaneevidgkseRG 178
Cdd:PRK12300 81 FSEEAKEDMKR----IGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCP-----------------ND 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 179 GHPVErrpmkqwmlkitayADRLLEDLEeldwPEsIKEMQRNWIGRSEGAhvhfavdgtneTFTVFTTRPDTLFGATYAV 258
Cdd:PRK12300 140 NNPVG--------------DHDLLDGEE----PE-IVEYTLIKFEESEDL-----------ILPAATLRPETIFGVTNLW 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 259 LAPEHDLV------QKITMPE--------QKDAVNaYIEEVQSKSdlertdlaktktgvFTGAYAVNPANGEKIPVWIAD 324
Cdd:PRK12300 190 VNPDATYVkaevdgEKWIVSKeaaeklsfQDRDVE-IIEEIKGSE--------------LIGKKVKNPVTGKEVPILPAD 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 325 YVLATYGTGAVMAVPAHD----------ERDHEFASAFGL------------PIKEVV-KGG-----DVEKEAYTGD--- 373
Cdd:PRK12300 255 FVDPDNGTGVVMSVPAHApydyvalrdlKKNKELLDVIEPiplievegygefPAKEVVeKLGiksqeDPELEEATKEvyr 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 374 --------GEHIHSdfLNGLDKAAAIEKMIQWLEENGKG-------EKKVTYR--------------------------- 411
Cdd:PRK12300 335 aefhkgvlKENTGE--YAGKPVREAREKITKDLIEKGIAdimyefsNRPVYCRcgtecvvkvvkdqwfidysdpewkela 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 412 ------------------------LRDWLFSRQRYWGEPIPiihWEDG-------TSTpvpeeelplILP---------K 451
Cdd:PRK12300 413 hkaldnmeiipeeyrkefentidwLKDRACARRRGLGTRLP---WDEEwiieslsDST---------IYMayytiahkiR 480
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 452 TSEIKPsgtgesplanikewvEVTDPEtgkkgrretntmpqwagscwyFLRYI--DPKNPNELA-----SPEKLKE---- 520
Cdd:PRK12300 481 EYGIKP---------------EQLTPE---------------------FFDYVflGKGDPEEVSkktgiPKEILEEmree 524
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 521 ---WLPVDMYIGGAEHAVLHLLYARFWHKFLYDigvvPTKEPfKQLYNQGMILGENnEKMSKSKGNVVNPDEIVETHGAD 597
Cdd:PRK12300 525 flyWYPVDWRHSGKDLIPNHLTFFIFNHVAIFP----EEKWP-RGIVVNGFVLLEG-KKMSKSKGNVIPLRKAIEEYGAD 598
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 598 TLRLYEMFMGPLDASIAWSTTGLDGARRFLDRvWRLFIDDNGGLNEKIVEGAGET-LERVYHETVMKVTDHFEGLRFNTG 676
Cdd:PRK12300 599 VVRLYLTSSAELLQDADWREKEVESVRRQLER-FYELAKELIEIGGEEELRFIDKwLLSRLNRIIKETTEAMESFQTRDA 677
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 677 IsQLMVF------------INEAYKAdqLPKEYMEGFVKLLSPVAPHLAEELWNRLGHEETIAYEAWPVYDEAKlVDDEI 744
Cdd:PRK12300 678 V-QEAFYellndlrwylrrVGEANNK--VLREVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSLEKWPEPDESK-IDEEA 753
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2747046742 745 EI-----------------VVQLNGKvKAKLNVpADADKEQLEELAKNNEKVKEQLE----GKTIRKVIAVPGKLVN 800
Cdd:PRK12300 754 ELaeeyvkrliedireilkVAKIKPK-KVYIYV-APDWKYEVLEIAAENGDVKEAIKelmkDEELRKHGKEVAKLAQ 828
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
2-779 |
7.94e-56 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 206.83 E-value: 7.94e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 2 SFDHQTIEKKWQDYWLKNKTFATREDKSKPKFYAldMFPYP--SGAgLHVGHPEGYTATDILSRMKRMQGYNVL------ 73
Cdd:COG0525 6 TYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTI--VIPPPnvTGS-LHMGHALNNTLQDILIRYKRMQGYNTLwqpgtd 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 74 ---------------------HPMGWDAFglpaEQYALDtgndpavFTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYY 132
Cdd:COG0525 83 hagiatqavverqlaeegksrHDLGREKF----LERVWE-------WKEESGGTITNQLRRLGASCDWSRERFTMDEGLS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 133 KWTQWIFLKLYEKGLAYVDEVPVNWCPALGTVLANEEVidgksergghpvERRPMKQWMlkitayadrlledleeldwpe 212
Cdd:COG0525 152 KAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV------------EHEEVKGHL--------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 213 sikemqrnWigrsegaHVHFAVDGTNETFTVFTTRPDTLFGATyAVlapehdlvqkitmpeqkdAVNayieevqsKSDlE 292
Cdd:COG0525 199 --------W-------HIRYPLADGSGYIVVATTRPETMLGDT-AV------------------AVH--------PED-E 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 293 R-TDLAktktgvftGAYAVNPANGEKIPVwIAD-YVLATYGTGAVMAVPAHDERDHEFASAFGLPIKEVVkggdvekeay 370
Cdd:COG0525 236 RyKHLI--------GKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIL---------- 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 371 TGDGeHI--HSDFLNGLDKAAAIEKMIQWLEENG---------------------------------------------- 402
Cdd:COG0525 297 DEDG-TIneNAGKYRGLDRFEARKAIVADLEELGllvkvephkhsvghsdrsgtviepylsdqwfvkmkplakpaieave 375
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 403 KGE--------KKvTYR-----LRDWLFSRQRYWGEPIPIIHWEDGtstpvpeeelplilpktseikpsgtgesplaniK 469
Cdd:COG0525 376 DGEikfvperwEK-TYFhwmenIRDWCISRQLWWGHRIPAWYCPDG---------------------------------E 421
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 470 EWVEVTDPE-----TGKKGRRETNTMPQWAGSC-WYFlryidpknpnelaS----PEK---LKEWLPVDMYIGGaehavl 536
Cdd:COG0525 422 VYVARTEPEacakaGSVNLTQDEDVLDTWFSSAlWPF-------------StlgwPEKtedLKYFYPTSVLVTG------ 482
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 537 hllyarfwhkflYDI-----------GVVPTKE-PFKQLYNQGMILGENNEKMSKSKGNVVNPDEIVETHGADTLRLYEM 604
Cdd:COG0525 483 ------------FDIiffwvarmimmGLHFTGEvPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLA 550
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 605 FMGPLDASIAWSTTGLDGARRFLDRVW---RlFIDDNGGLNEKIVEGAGETLERV-------YHETVMKVTDHFEGLRFN 674
Cdd:COG0525 551 ALASPGRDIKFDEERVEGYRNFANKLWnasR-FVLMNLEGFDPGLDPDPEELSLAdrwilsrLNKTIAEVTEALEKYRFD 629
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 675 TGISQLMVFI-NE------------AYKADQLPKE--------YMEGFVKLLSPVAPHLAEELWNRLG---HEETIAYEA 730
Cdd:COG0525 630 EAAQALYDFVwNEfcdwylelakprLYGGDEAAKRetratlvyVLEQILRLLHPFMPFITEEIWQKLPprkEGESIMLAP 709
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2747046742 731 WPVYDEAkLVDD----EIEIVVQLNGKV---KAKLNVPA--------DADKEQLEELAKNNEKV 779
Cdd:COG0525 710 WPEADEE-LIDEeaeaEFEWLKEVISAIrniRAEMNIPPskklplllKGADEADRARLEENAAY 772
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
40-615 |
2.28e-52 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 187.07 E-value: 2.28e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 40 PYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAE-----------QYALDTGNDPAV-----FTEQN 103
Cdd:cd00817 10 PNVTGS-LHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQvvvekklgiegKTRHDLGREEFLekcweWKEES 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 104 IDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCPALGTVLANEEVidgkSERGGHPVE 183
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 184 RRPMKQWMLKITAYADRLLedleeldwpESIKEMQRNWIgrsegahvhfavdgtnetftvfttrpdtlfgatyavlaPEH 263
Cdd:cd00817 165 PLLKPQWFVKVKDLAKKAL---------EAVKEGDIKFV--------------------------------------PER 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 264 dlvqkitmpeqkdavnayieevqsksdlertdlaktktgvftgayavnpangekipvWIADYVlatygtgavmavpahde 343
Cdd:cd00817 198 ---------------------------------------------------------MEKRYE----------------- 203
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 344 rdhefasafglpikevvkggdvekeaytgdgehihsdflngldkaaaiekmiQWLEEngkgekkvtyrLRDWLFSRQRYW 423
Cdd:cd00817 204 ----------------------------------------------------NWLEN-----------IRDWCISRQLWW 220
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 424 GEPIPIIHWEDGTSTPVPEEELPLILPKTSEIKPSGTGEsplanikEWVEVTDpetgkkgrretnTMPQWAGS-CWYFLR 502
Cdd:cd00817 221 GHRIPAWYCKDGGHWVVAREEDEAIDKAAPEACVPCGGE-------ELKQDED------------VLDTWFSSsLWPFST 281
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 503 YIDPKNpnelasPEKLKEWLPVDMYIGGaeHAVLhllyaRFW--------HKFLydigvvpTKEPFKQLYNQGMILGENN 574
Cdd:cd00817 282 LGWPEE------TKDLKKFYPTSLLVTG--HDII-----FFWvarmimrgLKLT-------GKLPFKEVYLHGLVRDEDG 341
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 2747046742 575 EKMSKSKGNVVNPDEIVETHGADTLRLYEMFMGPLDASIAW 615
Cdd:cd00817 342 RKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
1-745 |
1.33e-51 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 194.53 E-value: 1.33e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 1 MSFDHQTIEKKWQDYWLKNKTF-ATRED-KSKPKFYALDMFPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGW 78
Cdd:COG0060 14 MRANLPKREPEILKFWEENDIYeKSREArAGRPKFVLHDGPPYANGD-IHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 79 DAFGLPAE-----QYALDTGN----DPAVFTE-------QNIDNFRRQIRALGFSYDWDREVNTTDPDYYK--WtqWIFL 140
Cdd:COG0060 93 DCHGLPIElkvekELGIKKKDiekvGIAEFREkcreyalKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEEsiW--WALK 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 141 KLYEKGLAYVDEVPVNWCPALGTVLANEEVidgksergghpverrpmkqwmlkitAYADRllEDLeeldwpeSIkemqrn 220
Cdd:COG0060 171 KLYEKGLLYKGLKPVPWCPRCGTALAEAEV-------------------------EYKDV--TSP-------SI------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 221 wigrsegaHVHFAVDGT-------NETFTVFTTRPDTLFGATYAVLAPEHD--LVqKITMPEQ----KDAVNAYIEEvqs 287
Cdd:COG0060 211 --------YVKFPVKDEkalllleDAYLVIWTTTPWTLPANLAVAVHPDIDyvLV-EVTGGERlilaEALVEAVLKE--- 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 288 ksdLERTDLAKTKTgvFTGA-----------YAVNPANGEkIPVWIADYVLATYGTGAV-MAvPAHDERDHEFASAFGLP 355
Cdd:COG0060 279 ---LGIEDYEVLAT--FKGAeleglryehpfYYVVGYDRA-HPVILGDYVTTEDGTGIVhTA-PGHGEDDFEVGKKYGLP 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 356 I-----------KEV-------VKGGDVE-----KEAytG----DGEHIHS------------------------DFlng 384
Cdd:COG0060 352 VlnpvdddgrftEEAplfaglfVKDANPAiiedlKER--GallaREKITHSyphcwrcktpliyratpqwfismdKL--- 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 385 LDKA-AAIEKmIQWLEENGKGekkvtyRL-------RDWLFSRQRYWGEPIPIihWE-DGTSTPVPEEELplilpktsei 455
Cdd:COG0060 427 RDRAlEAIEK-VNWIPEWGEG------RFgnmlenrPDWCISRQRYWGVPIPI--WVcEDCGELHRTEEV---------- 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 456 kpsgtgespLANIKEWVE--------------------VTDPETGKKGRRETNTMPQW--AGSCWYF-LRyidpknpnel 512
Cdd:COG0060 488 ---------IGSVAELLEeegadawfeldlhrpfldetLKCPKCGGTMRRVPDVLDVWfdSGSMHFAvLE---------- 548
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 513 aspEKLKEWLPVDMYI-GGAEHavlhllyaRFWhkF---------LYDigvvptKEPFKQLYNQGMILGENNEKMSKSKG 582
Cdd:COG0060 549 ---NREELHFPADFYLeGSDQT--------RGW--FysslltstaLFG------RAPYKNVLTHGFVLDEDGRKMSKSLG 609
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 583 NVVNPDEIVETHGADTLRLYeMFMGPLDASIAWSTTGLDGARRFLDRVW---RLF---IDDNGGLNEKIVEGAGETLER- 655
Cdd:COG0060 610 NVVDPQEVIDKYGADILRLW-VASSDYWGDLRFSDEILKEVRDVYRRLRntyRFLlanLDDFDPAEDAVPYEDLPELDRw 688
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 656 ---VYHETVMKVTDHFEGLRFNTGISQLMVFINE---------------AYKADQLPK--------EYMEGFVKLLSPVA 709
Cdd:COG0060 689 ilsRLNELIKEVTEAYDNYDFHRAYRALHNFCVEdlsnwyldiskdrlyTEAADSLDRraaqttlyEVLETLVRLLAPIL 768
|
890 900 910
....*....|....*....|....*....|....*...
gi 2747046742 710 PHLAEELWNRL--GHEETIAYEAWPVYDEAkLVDDEIE 745
Cdd:COG0060 769 PFTAEEIWQNLpgEAEESVHLADWPEVDEE-LIDEELE 805
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
3-745 |
1.28e-43 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 170.94 E-value: 1.28e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 3 FDHQTIEKKWQDYWLKNKTFATRE-DKSKPKFYALdmFPYPSGAG-LHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDA 80
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEhDRTRPPFSIV--LPPPNVTGsLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDH 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 81 FGLpAEQYAL-------------DTGNDPAV-----FTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKL 142
Cdd:PRK14900 97 AGI-ATQMIVekelkktekksrhDLGREAFLervwaWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 143 YEKGLAYVDEVPVNWCPALGTVLANEEVidgksergghpvERRPMKQWMLkitayadrlledleeldwpesikemqrnWi 222
Cdd:PRK14900 176 HEEGLIYREKKLINWCPDCRTALSDLEV------------EHEEAHQGEL----------------------------W- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 223 grsegaHVHFAVDGTNETFTVFTTRPDTLFGATYAVLAPEHDLVQKITmpeqkdavnayieevqsksdlertdlaktktg 302
Cdd:PRK14900 215 ------SFAYPLADGSGEIVVATTRPETMLGDTAVAVHPLDPRYMALH-------------------------------- 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 303 vftGAYAVNPANGEKIPVwIADYVLA--TYGTGAVMAVPAHDERDHEFASAFGLPIKEVV-KGGDVEKEA--YTG----- 372
Cdd:PRK14900 257 ---GKKVRHPITGRTFPI-VADAILVdpKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIgPDGRMTAEAgpLAGldrfe 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 373 ---------------DGEHIHSDFLNGLDKAAAI-EKMI--QW-----------LEENGKGEKKV-------TY-----R 411
Cdd:PRK14900 333 arkevkrllaeqgldRGAKPHVLPLGRCQRSATIlEPLLsdQWyvrieplarpaIEAVEQGRTRFipeqwtnTYmawmrN 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 412 LRDWLFSRQRYWGEPIPIIHWEDGTstPVPEEELPLILPKTSeikpsgtgesplanikewvevtdpetGKKGRRETNTMP 491
Cdd:PRK14900 413 IHDWCISRQLWWGHQIPAWYCPDGH--VTVARETPEACSTCG--------------------------KAELRQDEDVLD 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 492 QWAGSC-WYFLRYIDPKNPNELaspeklKEWLPVDMYIGGaeHAVLHLLYARFWHKFLYDIGVVPtkepFKQLYNQGMIL 570
Cdd:PRK14900 465 TWFSSGlWPFSTMGWPEQTDTL------RTFYPTSVMETG--HDIIFFWVARMMMMGLHFMGEVP----FRTVYLHPMVR 532
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 571 GENNEKMSKSKGNVVNPDEIVETHGADTLRLYEMFMGPLDASIAWSTTGLDGARRFLDRVW---RLFIDDNGGLNEKIVE 647
Cdd:PRK14900 533 DEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWnasRFALMNLSGYQERGED 612
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 648 GAGET-----------LERVYHETVMKVtdhfEGLRFNTGISQLMVFI------------NEA-YKADQLPKEYMEGFV- 702
Cdd:PRK14900 613 PARLArtpadrwilarLQRAVNETVEAL----EAFRFNDAANAVYAFVwhelcdwyielaKEAlASEDPEARRSVQAVLv 688
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 2747046742 703 -------KLLSPVAPHLAEELWNRLghEETIAYEAWP------VYDEAKLVDDEIE 745
Cdd:PRK14900 689 hclqtsyRLLHPFMPFITEELWHVL--RAQVGASAWAdsvlaaEYPRKGEADEAAE 742
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
615-720 |
2.45e-40 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 143.90 E-value: 2.45e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 615 WSTTGLDGARRFLDRVWRLFIDDNGGLNEKIV----EGAGETLERVYHETVMKVTDHFEGLRFNTGISQLMVFINEAYKA 690
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAaaelSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMELVNALYKY 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 2747046742 691 D-------QLPKEYMEGFVKLLSPVAPHLAEELWNRL 720
Cdd:cd07958 81 KkkdaqhaAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
2-592 |
1.26e-34 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 142.45 E-value: 1.26e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 2 SFDHQTIEKKWQDYWLKNKTFATRED----KSKPKFYALdmFPYPSGAG-LHVGHPEGYTATDILSRMKRMQGYNVLHPM 76
Cdd:PTZ00419 27 SYDPKEVESGWYEWWEKSGFFKPAEDakslNSGKKFVIV--LPPPNVTGyLHIGHALTGAIQDSLIRYHRMKGDETLWVP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 77 GWDAFGLpAEQYAL-------------DTGNDPAV-----FTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWI 138
Cdd:PTZ00419 105 GTDHAGI-ATQVVVekklmkeenktrhDLGREEFLkkvweWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 139 FLKLYEKGLAYVDEVPVNWCPALGTVLANEEV--IDGKsergghpverrpmKQWMLKITAYaDRLLEdleeldwpesike 216
Cdd:PTZ00419 184 FVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVefEEIE-------------KPTKITIPGY-DKKVE------------- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 217 mqrnwigrsEGAHVHFA---VDGTNETFTVFTTRPDTLFGATyAVlapehdlvqkitmpeqkdAVNayieevqskSDLER 293
Cdd:PTZ00419 237 ---------VGVLWHFAyplEDSGQEEIVVATTRIETMLGDV-AV------------------AVH---------PKDER 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 294 -TDLaktktgvfTGAYAVNP-ANGEKIPVwIAD--YVLATYGTGAVMAVPAHDERDHEFASAFGLPI------------- 356
Cdd:PTZ00419 280 yKKL--------HGKELIHPfIPDRKIPI-IADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFiniftldgkinen 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 357 -------------KEVVK-----GGDVEKEAY---------TGDgehihsdflngldkaaAIEKMI--QW---------- 397
Cdd:PTZ00419 351 ggefagmhrfdcrRKIEEelkemGLLRDKVPNpmrlprcsrSGD----------------IVEPMLipQWyvnckdmakr 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 398 -LEENGKGEKKVT--------YR----LRDWLFSRQRYWGEPIPIIHWedgtstpvpeeelplilpKTSEIKPSGTGESP 464
Cdd:PTZ00419 415 aVEAVRNGELKIIpsshenvwYHwlenIQDWCISRQLWWGHRIPAYRV------------------ISKGPETDPSDEEP 476
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 465 L---ANIKEWVE-----VTDPETGKKGRRETNTMPQWAGS-CWYFlryidpknpNELASPEK---LKEWLPVDMYIGGae 532
Cdd:PTZ00419 477 WvvaRSEEEALEkakkkFGLSEEDFELEQDEDVLDTWFSSgLFPF---------STLGWPDQtddLQRFFPTSLLETG-- 545
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 533 HAVLHLLYARFWHKFLYDIGvvptKEPFKQLYNQGMILGENNEKMSKSKGNVVNPDEIVE 592
Cdd:PTZ00419 546 SDILFFWVARMVMMSLHLTD----KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIE 601
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
32-222 |
1.48e-34 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 134.47 E-value: 1.48e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 32 KFYALDMFPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYA-------------LDTGNDPAV 98
Cdd:cd00668 1 KFYVTTPPPYANGS-LHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 99 FTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYvdevpvnwcpalgtvlaneevidgkseRG 178
Cdd:cd00668 80 FVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIY---------------------------RG 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2747046742 179 GHPVerRPMKQWMLKITAYADRLLEDLEELDW-PESIKEMQRNWI 222
Cdd:cd00668 133 THPV--RITEQWFFDMPKFKEKLLKALRRGKIvPEHVKNRMEAWL 175
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
9-786 |
1.60e-34 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 142.22 E-value: 1.60e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 9 EKKWQDYWLKNKTFATREDKSKPKFYAL-DMFPYPSGaGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQ 87
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDRNNGESFTLhDGPPYANG-DLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIEL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 88 YALDTGND--------------PAVFTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEV 153
Cdd:PLN02843 88 KVLQSLDQearkeltpiklrakAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 154 PVNWCPALGTVLANEEvidgksergghpverrpmkqwmlkitayadrlledleeLDWPESikemqrnwiGRSEGAHVHFA 233
Cdd:PLN02843 168 PVHWSPSSRTALAEAE--------------------------------------LEYPEG---------HVSKSIYVAFP 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 234 VDGTNET-------------FTVFTTRPDTLFG---------ATYAVLAPEHDLVQKITMPEQKDAVNAYIEEVQSKSDL 291
Cdd:PLN02843 201 VVSPSETspeeleeflpglsLAIWTTTPWTMPAnaavavndkLQYSVVEVQSFSEDESTSGGNKKKRPGNVLKEQQKLFL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 292 -ERTDLAKT---KTGV-------FTGAYAVN-----PANGEKIPVWIA-DYVLATYGTGAVMAVPAHDERDHEFASAFGL 354
Cdd:PLN02843 281 iVATDLVPAleaKWGVklvvlktFPGSDLEGcryihPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGL 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 355 PI--------KEVVKGGDVEKEAYTGDGEHIHSDFLN--------------------------------------GLDKA 388
Cdd:PLN02843 361 PLlspvddagKFTEEAGQFSGLSVLGEGNAAVVEALDeagsllmeeayghkypydwrtkkptifrateqwfasveGFRQA 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 389 A--AIEKmIQWLEEngKGEKKVTYRL---RDWLFSRQRYWGEPIPIIHWEDgTSTPVPEEELplILPKTSEIKPSGTges 463
Cdd:PLN02843 441 AldAIDK-VKWIPA--QGENRIRAMVsgrSDWCISRQRTWGVPIPVFYHVE-TKEPLMNEET--IAHVKSIVAQKGS--- 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 464 planiKEW--VEVTD--PETGK----KGRRETNTMPQW--AGSCWyflryidpknpnelASPEKLKEWL--PVDMYIGGA 531
Cdd:PLN02843 512 -----DAWwyMDVEDllPEKYRdkasDYEKGTDTMDVWfdSGSSW--------------AGVLGSREGLsyPADLYLEGS 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 532 EHavlHllyaRFWHKFLYDIGVVPT-KEPFKQLYNQGMILGENNEKMSKSKGNVVNPDEIVE---------THGADTLRL 601
Cdd:PLN02843 573 DQ---H----RGWFQSSLLTSVATKgKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEggknqkqepAYGADVLRL 645
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 602 Y--------EMFMGPldaSIAWSTTG----LDGARRFLDRVWRLFIDDNGGLNEKIVEGAGETLERVyHETVMKVTDHFE 669
Cdd:PLN02843 646 WvasvdytgDVLIGP---QILKQMSDiyrkLRGTLRYLLGNLHDWKPDNAVPYEDLPSIDKYALFQL-ENVVNEIEESYD 721
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 670 GLRFNTGISQLMVFI-------------NEAY---------KADQ-LPKEYMEGFVKLLSPVAPHLAEELWNRLGHEET- 725
Cdd:PLN02843 722 NYQFFKIFQILQRFTivdlsnfyldvakDRLYvggttsftrRSCQtVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDg 801
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2747046742 726 ----IAYEA-WPVYDEAKLVDDEIEI-----VVQLNGKVKAKLnvpadadkeqleELAKNNEKVKEQLEGK 786
Cdd:PLN02843 802 saaeSVFEAgWPTPNEEWLSFPAEDVdfwslLLEVRDEVNKVL------------ESARNGKLIGASLEAK 860
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
2-732 |
6.49e-28 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 120.82 E-value: 6.49e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 2 SFDHqTIEKKWQDYWLKNKTFATREDKSKPKFyALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAF 81
Cdd:PLN02943 60 SFDF-TSEERIYNWWESQGYFKPNFDRGGDPF-VIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 82 GLpAEQYAL------------DTGNDPavFTEQ----------NIDNfrrQIRALGFSYDWDREVNTTDPDYYKWTQWIF 139
Cdd:PLN02943 138 GI-ATQLVVekmlasegikrtDLGRDE--FTKRvwewkekyggTITN---QIKRLGASCDWSRERFTLDEQLSRAVVEAF 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 140 LKLYEKGLAYVDEVPVNWCPALGTVLANEEVidGKSERGGhpverrpmkqwmlkiTAYadrlledleeldwpesikemqr 219
Cdd:PLN02943 212 VRLHEKGLIYQGSYMVNWSPNLQTAVSDLEV--EYSEEPG---------------TLY---------------------- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 220 nwigrsegaHVHFAVDGTNETF-TVFTTRPDTLFGATYAVLAPEHDLVQKitmpeqkdavnayieevqsksdlertdlak 298
Cdd:PLN02943 253 ---------YIKYRVAGGSEDFlTIATTRPETLFGDVAIAVNPEDDRYSK------------------------------ 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 299 tktgvFTGAYAVNPAN-GEKIPVwIAD-YVLATYGTGAVMAVPAHDERDHEFASAFGLPIKEVV-KGGDVEKEAytgdge 375
Cdd:PLN02943 294 -----YIGKMAIVPMTyGRHVPI-IADrYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMnKDGTLNEVA------ 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 376 hihsdflnGLDKAAAIEKMIQWLEENGKGEKKVTYRLRdwlFSRQRYWGEPI-PII--HWEdGTSTPVPEEELPLILPKT 452
Cdd:PLN02943 362 --------GLYWFEAREKLWSDLEETGLAVKKEPHTLR---VPRSQRGGEVIePLVskQWF-VTMEPLAEKALKAVENGE 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 453 SEIKP---SGTGESPLANIKEW---------------------------VEVTDPETGKKGR----------RETNTMPQ 492
Cdd:PLN02943 430 LTIIPerfEKIYNHWLSNIKDWcisrqlwwghripvwyivgkdceedyiVARSAEEALEKARekygkdveiyQDPDVLDT 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 493 W-AGSCWYFLRYIDPKnpnelASPEKLKEWLPVDMYIGGaeHAVLHllyarFWHKFLYDIGVVPT-KEPFKQLYNQGMIL 570
Cdd:PLN02943 510 WfSSALWPFSTLGWPD-----VSAEDFKKFYPTTVLETG--HDILF-----FWVARMVMMGIEFTgTVPFSYVYLHGLIR 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 571 GENNEKMSKSKGNVVNPDEIVETHGADTLRlYEMFMGPLDASIAWSTTGLDGARRFLDRVWRL--FIDDN------GGLN 642
Cdd:PLN02943 578 DSQGRKMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTSNKAFTNKLWNAgkFVLQNlpsqsdTSAW 656
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 643 EKIVEGAGETLERV-------------YHETVMKVTDHFEGLRFNTGISQLMVFI---------------------NEAY 688
Cdd:PLN02943 657 EHILACKFDKEESLlslplpecwvvskLHELIDSVTTSYDKYFFGDVGREIYDFFwsdfadwyieasktrlyhsgdNSAL 736
|
810 820 830 840
....*....|....*....|....*....|....*....|....*.
gi 2747046742 689 KADQLPKEYM-EGFVKLLSPVAPHLAEELWNRLGHE-ETIAYEAWP 732
Cdd:PLN02943 737 SRAQAVLLYVfENILKLLHPFMPFVTEELWQALPYRkEALIVSPWP 782
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
40-222 |
4.01e-27 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 112.63 E-value: 4.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 40 PYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAVFTEQNIDNFRRQIRALGFSYD 119
Cdd:cd00814 9 PYVNGV-PHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFKWLNISFD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 120 -WDRevnTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCPALGTVLAneevidgksergghpvERRPMKQWMLKITAYA 198
Cdd:cd00814 88 yFIR---TTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYFFRLSKFQ 148
|
170 180
....*....|....*....|....*..
gi 2747046742 199 DRLLEDLEE---LDWPESIKEMQRNWI 222
Cdd:cd00814 149 DRLLEWLEKnpdFIWPENARNEVLSWL 175
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
31-222 |
6.09e-27 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 115.98 E-value: 6.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 31 PKFY---ALdmfPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAVFTEQNIDNF 107
Cdd:COG0143 1 KKFLvttAI---PYANGP-PHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 108 RRQIRALGFSYD-WDRevnTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCP--------------------------- 159
Cdd:COG0143 77 KELFEKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPecerflpdryvegtcpkcgaedaygdq 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2747046742 160 --ALGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEEL-DW-PESIKEMQrNWI 222
Cdd:COG0143 154 ceNCGATLEPTELINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENpDIqPEVRNEVL-SWL 219
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
40-219 |
8.23e-25 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 109.20 E-value: 8.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 40 PYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAVFTEQNIDNFRRQIRALGFSYD 119
Cdd:PRK11893 10 YYPNGK-PHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEALNISYD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 120 wdREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCPALGTVLANEEVIDGK--SERGGHPVERRPMKQWMLKITAY 197
Cdd:PRK11893 89 --DFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDGyrCPPTGAPVEWVEEESYFFRLSKY 166
|
170 180
....*....|....*....|....*.
gi 2747046742 198 ADRLLEDLEELDW---PESI-KEMQR 219
Cdd:PRK11893 167 QDKLLELYEANPDfiqPASRrNEVIS 192
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
39-222 |
1.30e-24 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 106.99 E-value: 1.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 39 FPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAVFTEQNIDNFRRQIRALGFSY 118
Cdd:pfam09334 7 LPYANGP-PHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKKFNISF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 119 D-WDRevnTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA-----------------------------LGTVLANE 168
Cdd:pfam09334 86 DdYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSderflpdryvegtcphcgsedargdqcenCGRHLEPT 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2747046742 169 EVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEE--LDWPESIKEMQRNWI 222
Cdd:pfam09334 163 ELINPKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEEnnPEWPENVKNMVLEWL 218
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
31-602 |
3.19e-24 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 104.62 E-value: 3.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 31 PKFYALDMFPYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAV------------ 98
Cdd:cd00818 1 PEFVFHDGPPYANGL-PHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKkdiekmgiaefn 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 99 -----FTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWcpalgtvlaneevidg 173
Cdd:cd00818 80 akcreFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW---------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 174 ksergghPVERRPMKQWMLKITAYADRLLEDLEELDW-PESIKEMQRNWIGrsegahvhfavdgtnetftvfttrpdtlf 252
Cdd:cd00818 144 -------PLIYRATPQWFIRVTKIKDRLLEANDKVNWiPEWVKNRFGNWLE----------------------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 253 gatyavlapehdlvqkitmpeqkdavnayieevqsksdlertdlaktktgvftgayavnpangekipvwiadyvlatygt 332
Cdd:cd00818 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 333 gavmavpahderdhefasafglpikevvkggdvekeaytgdgehihsdflngldkaaaiekmiqwleengkgekkvtyRL 412
Cdd:cd00818 188 ------------------------------------------------------------------------------NR 189
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 413 RDWLFSRQRYWGEPIPIIHWEDGtstpvpEEELPlilpktseikpsgtgesplanikewvevtdpetgkkgRRETNTMPQ 492
Cdd:cd00818 190 RDWCISRQRYWGTPIPVWYCEDC------GEVLV-------------------------------------RRVPDVLDV 226
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 493 W--AGSCWYFLRYIDPKNpnelaspEKLKEWLPVDMYIGGAEHavlhllyARFWHKFLYDIGV-VPTKEPFKQLYNQGMI 569
Cdd:cd00818 227 WfdSGSMPYAQLHYPFEN-------EDFEELFPADFILEGSDQ-------TRGWFYSLLLLSTaLFGKAPYKNVIVHGFV 292
|
570 580 590
....*....|....*....|....*....|...
gi 2747046742 570 LGENNEKMSKSKGNVVNPDEIVETHGADTLRLY 602
Cdd:cd00818 293 LDEDGRKMSKSLGNYVDPQEVVDKYGADALRLW 325
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
7-614 |
5.53e-24 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 108.45 E-value: 5.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 7 TIEKKWQDYWLKNKTFATREDKSKPKFYALdmFPYPSGAG-LHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLpA 85
Cdd:PLN02381 104 AVEKSWYAWWEKSGYFGADAKSSKPPFVIV--LPPPNVTGaLHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGI-A 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 86 EQYAL-------------DTGNDPAV-----FTEQNIDNFRRQIRALGFSYDWDREVNTTDPDYYKWTQWIFLKLYEKGL 147
Cdd:PLN02381 181 TQVVVekklmrerhltrhDIGREEFVsevwkWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGL 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 148 AYVDEVPVNWCPALGTVLANEEV--IDGKSERgghpverrpmkqwMLKITAYADRLledleeldwpesikemqrnwigrS 225
Cdd:PLN02381 261 IYRDIRLVNWDCTLRTAISDVEVdyIDIKERT-------------LLKVPGYDKPV-----------------------E 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 226 EGAHVHFA--VDGTNETFTVFTTRPDTLFGATYAVLAPEhdlvqkitmpeqkDAVNAYIEevqsksdlertdlaktktgv 303
Cdd:PLN02381 305 FGVLTSFAypLEGGLGEIVVATTRIETMLGDTAIAIHPD-------------DERYKHLH-------------------- 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 304 ftGAYAVNPANGEKIPVwIADYVLA--TYGTGAVMAVPAHDERDH--------EFASAF---------------GLP--- 355
Cdd:PLN02381 352 --GKFAVHPFNGRKLPI-ICDAILVdpNFGTGAVKITPAHDPNDFevgkrhnlEFINIFtddgkinsnggsefaGMPrfa 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 356 IKEVVKGGDVEKEAYTG-DGEHIHSDFLNGLDKaaAIEKMI--QWL----------------EENGKGE----------K 406
Cdd:PLN02381 429 AREAVIEALQKKGLYRGaKNNEMRLGLCSRTND--VVEPMIkpQWFvncssmakqaldaaidGENKKLEfipkqylaewK 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 407 KVTYRLRDWLFSRQRYWGEPIPIihWedgtsTPVPEEELPLILPKTSEIKPSGTGESPlANikewVEVTDPETGKKGR-- 484
Cdd:PLN02381 507 RWLENIRDWCISRQLWWGHRIPA--W-----YVTLEDDQLKELGSYNDHWVVARNESD-AL----LEASQKFPGKKFEls 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 485 RETNTMPQWAGSCWYFLRYID-PKNPNElaspekLKEWLPVDMYIGGaeHAVLHllyarFWHKFLYDIGVVPTKE-PFKQ 562
Cdd:PLN02381 575 QDPDVLDTWFSSGLFPLSVLGwPDDTDD------LKAFYPTSVLETG--HDILF-----FWVARMVMMGMQLGGDvPFRK 641
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....
gi 2747046742 563 LYNQGMILGENNEKMSKSKGNVVNPDEIVETHGADTL--RLYEMFMGPLDASIA 614
Cdd:PLN02381 642 VYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLhkRLEEGNLDPKELVVA 695
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
653-767 |
2.69e-19 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 84.76 E-value: 2.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 653 LERVYHETVMKVTDHFEGLRFNTGISQLMVFINEAY-------------------KADQLPKEYMEGFVKLLSPVAPHLA 713
Cdd:pfam08264 4 ILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLsdwylelikdrlygeepdsRAQTTLYEVLETLLRLLAPFMPFIT 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2747046742 714 EELWnrlgHEETIAYEAWPVYDEAKLVDDEIEI-----VVQLNGKVKAKLNVPADADKE 767
Cdd:pfam08264 84 EELW----QKESIHLAPWPEDAELEEAELEEAFelrqeIVQAIRKLRSELKIKKSLPLE 138
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
3-602 |
2.37e-18 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 90.55 E-value: 2.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 3 FDHQTIEKKWQDYWLKNKTFAT--REDKSKPKFYALDMFPYPSGAGlHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDA 80
Cdd:PLN02882 8 FSFPKQEEKILSLWSEIDAFKTqlKRTEGLPEYIFYDGPPFATGLP-HYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDC 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 81 FGLPAEqYALD-----TGNDPAVftEQNIDNFRRQIRALGFSY--DWDREV-------------NTTDPDYYKWTQWIFL 140
Cdd:PLN02882 87 HGLPVE-YEIDkklgiKRRDDVL--KMGIDKYNEECRSIVTRYskEWEKTVtrtgrwidfendyKTMDPKFMESVWWVFK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 141 KLYEKGLAYVDEVPVNWCPALGTVLANEEVidGKSERgghpverrpmkqwmlkitayadrlledleELDWPESIkemqrn 220
Cdd:PLN02882 164 QLFEKGLVYKGFKVMPYSTACKTPLSNFEA--GLNYK-----------------------------DVSDPAVM------ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 221 wigrsegahVHFAV--DGTNETFTVFTTRPDTLFGATYAVLAPEHDLVQKitmpEQKDAVNAYIeevQSKSDLERTDLAK 298
Cdd:PLN02882 207 ---------VSFPIvgDPDNASFVAWTTTPWTLPSNLALCVNPNFTYVKV----RNKYTGKVYI---VAESRLSALPTAK 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 299 TKTGvfTGAYAVNPANG----EKIP-------------------------VWIADYVLATYGTGAVMAVPAHDERDHEFA 349
Cdd:PLN02882 271 PKSK--KGSKPENAAEGyevlAKVPgsslvgkkyeplfdyfsefsdtafrVVADDYVTDDSGTGVVHCAPAFGEDDYRVC 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 350 SAFGLpikeVVKGGDVeKEAYTGDGEHIH--SDFLnGLDKAAAIEKMIQWLEENG------------------------- 402
Cdd:PLN02882 349 LANGI----IEKGGNL-PVPVDDDGCFTEkvTDFS-GRYVKDADKDIIAAIKAKGrlvksgsithsypfcwrsdtpliyr 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 403 -------KGEK---------KVTY---------RL-------RDWLFSRQRYWGEPIPIIHWEDGtstpvpeEELPLI-- 448
Cdd:PLN02882 423 avpswfvKVEEikdrllennKQTYwvpdyvkekRFhnwlenaRDWAVSRSRFWGTPLPIWISDDG-------EEVVVIgs 495
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 449 ---LPKTSEIK--------------PS--GTGESPLANIKE----WVevtdpetgkkgrrETNTMPqwagscWYFLRYid 505
Cdd:PLN02882 496 iaeLEKLSGVKvtdlhrhfidhitiPSsrGPEFGVLRRVDDvfdcWF-------------ESGSMP------YAYIHY-- 554
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 506 pknPNElaSPEKLKEWLPVDMYIGGaehavlhLLYARFWhkfLYDIGVVPT----KEPFKQLYNQGMILGENNEKMSKSK 581
Cdd:PLN02882 555 ---PFE--NKELFEKNFPADFVAEG-------LDQTRGW---FYTLMVLSTalfdKPAFKNLICNGLVLAEDGKKMSKSL 619
|
730 740
....*....|....*....|.
gi 2747046742 582 GNVVNPDEIVETHGADTLRLY 602
Cdd:PLN02882 620 KNYPDPNEVIDKYGADALRLY 640
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
28-207 |
1.40e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 77.53 E-value: 1.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 28 KSKPKFYALDMFPYPSGAgLHVGHpeGYT--ATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAVFTEQNID 105
Cdd:PRK12267 1 MMKKTFYITTPIYYPNGK-PHIGH--AYTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 106 NFRRQIRALGFSYdwDREVNTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCPALGTVLANEEVID-GKSERGGHPVER 184
Cdd:PRK12267 78 GFKELWKKLDISY--DKFIRTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVDgGKCPDCGREVEL 155
|
170 180
....*....|....*....|...
gi 2747046742 185 RPMKQWMLKITAYADRLLEDLEE 207
Cdd:PRK12267 156 VKEESYFFRMSKYQDRLLEYYEE 178
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
40-222 |
7.57e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 75.19 E-value: 7.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 40 PYPSGAgLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPavftEQNIDNFRRQIRA----LG 115
Cdd:PRK00133 11 PYANGP-IHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITP----EELIARYHAEHKRdfagFG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 116 FSYD-WDRevnTTDPDYYKWTQWIFLKLYEKGLAYVDEVPVNWCP-----------------------------ALGTVL 165
Cdd:PRK00133 86 ISFDnYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPekgmflpdrfvkgtcpkcgaedqygdnceVCGATY 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2747046742 166 ANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLE-ELDWPESIKEMQRNWI 222
Cdd:PRK00133 163 SPTELINPKSAISGATPVLKESEHFFFKLPRFEEFLKEWITrSGELQPNVANKMKEWL 220
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
516-727 |
2.12e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 70.60 E-value: 2.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 516 EKLKEWLPVDMYIGGAE----HAVlhllyarFWHKFLYDIGVvptkEPFKQLYNQGMILGENnEKMSKSKGNVVNPDEIV 591
Cdd:PRK12267 247 ELFKKFWPADVHLVGKDilrfHAI-------YWPIMLMALGL----PLPKKVFAHGWWLMKD-GKMSKSKGNVVDPEELV 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 592 ETHGADTLRLY---EMfmgpldasiawsTTGLDGA---RRFLDRVWRLFIDDNGGL-----------------NEKIVEG 648
Cdd:PRK12267 315 DRYGLDALRYYllrEV------------PFGSDGDfspEALVERINSDLANDLGNLlnrtvaminkyfdgeipAPGNVTE 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 649 AGETLERVYHETVMKVTDHFEGLRFNTGISQLMVFINEAYKA-DQ-----LPKEY-------------MEGFVK---LLS 706
Cdd:PRK12267 383 FDEELIALAEETLKNYEELMEELQFSRALEEVWKLISRANKYiDEtapwvLAKDEgkkerlatvmyhlAESLRKvavLLS 462
|
250 260
....*....|....*....|.
gi 2747046742 707 PVAPHLAEELWNRLGHEETIA 727
Cdd:PRK12267 463 PFMPETSKKIFEQLGLEEELT 483
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
509-724 |
2.46e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 69.91 E-value: 2.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 509 PNELASPEKLKEWLPVDMYIGGAEHAVLHLLYarfWHKFLYDIGV-VPTK---EPFkqLYNQGmilgennEKMSKSKGNV 584
Cdd:PRK11893 240 DDEELLAELFNKYWPADVHLIGKDILRFHAVY---WPAFLMAAGLpLPKRvfaHGF--LTLDG-------EKMSKSLGNV 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 585 VNPDEIVETHGADTLRLY---------------EMFMGPLDASIAWS-------TTGLDgARRFLDRVWRlfIDDNGGLN 642
Cdd:PRK11893 308 IDPFDLVDEYGVDAVRYFllreipfgqdgdfsrEAFINRINADLANDlgnlaqrTLSMI-AKNFDGKVPE--PGALTEAD 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 643 EKIVEGAGETLERVYHetvmkvtdHFEGLRFNTGISQLMVFINEA--YKADQLP-------KEYME-----------GFV 702
Cdd:PRK11893 385 EALLEAAAALLERVRA--------AMDNLAFDKALEAILALVRAAnkYIDEQAPwslaktdPERLAtvlytllevlrGIA 456
|
250 260
....*....|....*....|..
gi 2747046742 703 KLLSPVAPHLAEELWNRLGHEE 724
Cdd:PRK11893 457 VLLQPVMPELAAKILDQLGVEE 478
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
413-602 |
3.60e-11 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 66.91 E-value: 3.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 413 RDWLFSRQRYWGEPIPIihWEDGTSTPVPEEELPLILPKTSEIKpsgtgesplaNIKEW-------VEVTDP--ETGKKG 483
Cdd:PTZ00427 569 KDWCISRNRYWGTPIPI--WADEKMETVICVESIKHLEELSGVK----------NINDLhrhfidhIEIKNPkgKTYPKL 636
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 484 RRETNTMpqwagSCWY---FLRYIDPKNPNELASpEKLKEWLPVDMYIGGAEHAvlhllyaRFWhkfLYDIGVVPT---- 556
Cdd:PTZ00427 637 KRIPEVF-----DCWFesgSMPYAKVHYPFSTEK-EDFHKIFPADFIAEGLDQT-------RGW---FYTLLVISTllfd 700
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2747046742 557 KEPFKQLYNQGMILGENNEKMSKSKGNVVNPDEIVETHGADTLRLY 602
Cdd:PTZ00427 701 KAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLY 746
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
573-637 |
3.80e-08 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 56.65 E-value: 3.80e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2747046742 573 NNEKMSKSKGNVVNPDEIVETHGADTLRLYeMFMG----PLDasiaWSTTGLDGARRFLDRvWRLFIDD 637
Cdd:COG0215 262 NGEKMSKSLGNFFTVRDLLKKYDPEVLRFF-LLSAhyrsPLD----FSEEALEEAEKALER-LYNALRR 324
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
521-778 |
4.26e-07 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 53.92 E-value: 4.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 521 WLPVDMYIGGAEHAVLHLLYARFWHKFLYDigvvptKEPF-KQLYNQGMILgENNEKMSKSKGNVVNPDEIVETHGADTL 599
Cdd:PLN02959 669 WYPFDLRVSGKDLIQNHLTFAIYNHTAIWA------EEHWpRGFRCNGHLM-LNSEKMSKSTGNFLTLRQAIEEFSADAT 741
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 600 RLyemfmgpldaSIAWSTTGLDGARRFLDR----VWRL-----FIDDNGGLNEKIVEGAGETL-ERVY-HET---VMKVT 665
Cdd:PLN02959 742 RF----------ALADAGDGVDDANFVFETanaaILRLtkeiaWMEEVLAAESSLRTGPPSTYaDRVFeNEIniaIAETE 811
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 666 DHFEGLRF----NTGISQLMVFINEaYKA--------DQLPKEYMEGFVKLLSPVAPHLAEELWNRLGHEETIAYEA-WP 732
Cdd:PLN02959 812 KNYEAMMFrealKSGFYDLQAARDE-YRLscgsggmnRDLVWRFMDVQTRLITPICPHYAEHVWREILKKEGFAVTAgWP 890
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 733 VYDE--------AKLVDDEIE-----IVVQLNG-KVKAKLNVPADADKEQLEELAKNNEK 778
Cdd:PLN02959 891 VAGEpdltlkraNKYLQDSIVsfrklLQKQLAGsKKAKKGGAPVTLPEKKLAGLIYVAEK 950
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
8-146 |
1.06e-06 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 52.38 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 8 IEKKWQDYWLKNKTFAT----REDKSKPKFYAldMFPYPSGAG-LHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFG 82
Cdd:PLN02959 18 IEVAVQKWWEEEKVFEAeagdEPPKPGEKFFG--NFPYPYMNGlLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 83 LP-----------AEQY-----------------------ALDTGNDPAVF--------------------------TEQ 102
Cdd:PLN02959 96 MPikasadklareIQQYgnppvfpeededeaaavaaakaeAEAAAAPPDKFkgkkskavaksgtqkyqweimrsfglPDS 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 103 NIDNFR--------------RQIRALGFSYDWDREVNTTD--PDYYKWTQWIFLKLYEKG 146
Cdd:PLN02959 176 EIAKFQdpyhwlsyfpplakEDLKAFGLGCDWRRSFITTDvnPYYDAFVRWQFRKLKKKG 235
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
642-720 |
1.99e-06 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 47.20 E-value: 1.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 642 NEKIVEGAGETLERVY---------------------------HETVMKVTDHFEGLRF----NTGISQLMVFINE---- 686
Cdd:cd07959 2 REEEANSAILRLERFYelaeelietegeleeltfidrwllsrlNRLIKETTEAYENMQFrealKEGLYELQNDLDWyrer 81
|
90 100 110
....*....|....*....|....*....|....*.
gi 2747046742 687 --AYKADQLPKEYMEGFVKLLSPVAPHLAEELWNRL 720
Cdd:cd07959 82 ggAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
657-745 |
3.87e-06 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 47.93 E-value: 3.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 657 YHETVMKVTDHFEGLRFNTGISQLMVFINEA-----------YKADQLPKE--------Y--MEGFVKLLSPVAPHLAEE 715
Cdd:cd07961 56 LNSLIKEVTEEMEAYDLYTAVRALLEFIDELtnwyirrnrkrFWGEEGDDDklaayatlYevLLTLSRLMAPFTPFITEE 135
|
90 100 110
....*....|....*....|....*....|....*
gi 2747046742 716 LWNRL-----GHEETIAYEAWPVYDEAkLVDDEIE 745
Cdd:cd07961 136 IYQNLrrelgDAPESVHLLDWPEVDES-LIDEELE 169
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
615-720 |
1.23e-05 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 45.63 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 615 WSTTGLDGARRFLDRVW---RlFIDDNGGlNEKIVEGAGETLERV-------YHETVMKVTDHFEGLRFNTGISQLMVFI 684
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWnaaR-FVLMNLE-DDDEPEEDPESLSLAdrwilsrLNKTVEEVTEALENYRFSEAATALYEFF 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2747046742 685 -------------NEAYKADQLPKEY--------MEGFVKLLSPVAPHLAEELWNRL 720
Cdd:cd07962 79 wndfcdwylelvkPRLYGEDEEEKKAaratlyyvLETILRLLHPFMPFITEELWQRL 135
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
658-745 |
2.53e-05 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 45.59 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 658 HETVMKVTDHFEGLRFNTGISQLMVFINE---------------AYKADQLP--------KEYMEGFVKLLSPVAPHLAE 714
Cdd:cd07960 54 NELIKEVREAYENYEFHKVYQALNNFCTVdlsafyldiikdrlyCDAKDSLErrsaqtvlYHILDALLKLLAPILPFTAE 133
|
90 100 110
....*....|....*....|....*....|....
gi 2747046742 715 ELWNRLGH---EETIAYEAWPVYDEAKLvDDEIE 745
Cdd:cd07960 134 EVWEHLPGekkEESVFLEDWPELPEEWK-DEELE 166
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
573-602 |
7.06e-04 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 41.80 E-value: 7.06e-04
10 20 30
....*....|....*....|....*....|
gi 2747046742 573 NNEKMSKSKGNVVNPDEIVETHGADTLRLY 602
Cdd:cd00672 171 DGEKMSKSLGNFITVRDALKKYDPEVLRLA 200
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
59-171 |
1.22e-03 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 42.46 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2747046742 59 DILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPavftEQNIDNF---RRQIralgfsYDW-----DREVNTTDPD 130
Cdd:PLN02610 45 DVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTP----KEICDKYhaiHKEV------YDWfdisfDKFGRTSTPQ 114
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2747046742 131 YYKWTQWIFLKLYEKGLAYVDEVPVNWCPALGTVLANEEVI 171
Cdd:PLN02610 115 QTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLVE 155
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
568-608 |
3.27e-03 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 40.95 E-value: 3.27e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 2747046742 568 MILGENNEKMSKSKGNVVNPDEIVETHGADTLRLYeMFMGP 608
Cdd:PRK00750 272 LFLDKKGEKISKSKGNVITIEDWLEYAPPESLRLF-MFARP 311
|
|
| |
