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Conserved domains on  [gi|2753373729|ref|WP_353770087|]
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SH3 domain-containing protein, partial [Bacillus toyonensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14081 super family cl28461
triple tyrosine motif-containing protein; Provisional
 311-410 2.00e-10

triple tyrosine motif-containing protein; Provisional


The actual alignment was detected with superfamily member PRK14081:

Pssm-ID: 237602 [Multi-domain]  Cd Length: 667  Bit Score: 62.75  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 311 IKVKKAEKVNNVKVVTDKVGPQsIGTPITLTATSEGSNQPQYKFNVYDGNTWKVVQDYSDKSTYVWKPEKAGTYKFSVHA 390
Cdd:PRK14081  569 FYVREALPITNTKIKTSKKKFK-CNEEVTFSVKSEGGKDVCYEFYIMEKGEWKLVQKYSRKNYYSFMPFNKGKYKVLVLC 647

                          90       100
                  ....*....|....*....|
gi 2753373729 391 KDANSQTAYDSYYAFDYKVE 410
Cdd:PRK14081  648 KSYYKKCAYEDYDIFEFKVE 667
MltE super family cl43257
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 54-158 2.71e-10

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG0741:

Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 60.39  E-value: 2.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  54 LLTSAALDAKIPPEVVKAVAKQESSWRQFVngqpfISQDGGIGLMQItnKPS-----------YDQQKLKYDIKYNIQAG 122
Cdd:COG0741   106 LIEEAAKKYGVDPALVLALIRQESAFNPNA-----VSPAGARGLMQL--MPAtarrlglklglGPSPDDLFDPETNIRAG 178

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2753373729 123 IEILNNMYSwgdlpKIKGagpeiieNWYFPIMAYNG 158
Cdd:COG0741   179 AAYLRELLD-----RFDG-------DLVLALAAYNA 202
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
243-310 9.24e-10

Uncharacterized conserved protein YraI [Function unknown];


:

Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 55.07  E-value: 9.24e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2753373729 243 VVVTGNEVNLRSKPNTSSSVVSVLAKGTNVTIDGdflydqSLADNPfvWYPVKTADQKlvGYISSAYV 310
Cdd:COG4991    24 TAVATDDLNLRSGPGTGYPVVGTLPAGATVTVLG------CTSGGG--WCKVSYGGQR--GWVSARYL 81
 
Name Accession Description Interval E-value
PRK14081 PRK14081
triple tyrosine motif-containing protein; Provisional
 311-410 2.00e-10

triple tyrosine motif-containing protein; Provisional


Pssm-ID: 237602 [Multi-domain]  Cd Length: 667  Bit Score: 62.75  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 311 IKVKKAEKVNNVKVVTDKVGPQsIGTPITLTATSEGSNQPQYKFNVYDGNTWKVVQDYSDKSTYVWKPEKAGTYKFSVHA 390
Cdd:PRK14081  569 FYVREALPITNTKIKTSKKKFK-CNEEVTFSVKSEGGKDVCYEFYIMEKGEWKLVQKYSRKNYYSFMPFNKGKYKVLVLC 647

                          90       100
                  ....*....|....*....|
gi 2753373729 391 KDANSQTAYDSYYAFDYKVE 410
Cdd:PRK14081  648 KSYYKKCAYEDYDIFEFKVE 667
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 54-158 2.71e-10

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 60.39  E-value: 2.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  54 LLTSAALDAKIPPEVVKAVAKQESSWRQFVngqpfISQDGGIGLMQItnKPS-----------YDQQKLKYDIKYNIQAG 122
Cdd:COG0741   106 LIEEAAKKYGVDPALVLALIRQESAFNPNA-----VSPAGARGLMQL--MPAtarrlglklglGPSPDDLFDPETNIRAG 178

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2753373729 123 IEILNNMYSwgdlpKIKGagpeiieNWYFPIMAYNG 158
Cdd:COG0741   179 AAYLRELLD-----RFDG-------DLVLALAAYNA 202
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
243-310 9.24e-10

Uncharacterized conserved protein YraI [Function unknown];


Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 55.07  E-value: 9.24e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2753373729 243 VVVTGNEVNLRSKPNTSSSVVSVLAKGTNVTIDGdflydqSLADNPfvWYPVKTADQKlvGYISSAYV 310
Cdd:COG4991    24 TAVATDDLNLRSGPGTGYPVVGTLPAGATVTVLG------CTSGGG--WCKVSYGGQR--GWVSARYL 81
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 64-178 2.71e-09

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 54.62  E-value: 2.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  64 IPPEVVKAVAKQESSWrqfvngQPF-ISQDGGIGLMQI---TNKPSYDQQKLKYDIKY----NIQAGIEILNNMYSWGDl 135
Cdd:pfam01464  10 VDPSLLLAIAQQESGF------NPKaVSKSGAVGLMQImpsTAKRLGLRVNPGVDDLFdpekNIKAGTKYLKELYKQYG- 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2753373729 136 pkikgagpeiiENWYFPIMAYN-GIKPINSPLKQsTGERNPIAY 178
Cdd:pfam01464  83 -----------GDLWLALAAYNaGPGRVRKWIKN-AGAKDKKLL 114
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 66-158 1.60e-07

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 49.52  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  66 PEVVKAVAKQESSWRQFVngqpfISQDGGIGLMQIT----NKPSYDQQKLKYDIKYNIQAGIEILNNMYSwgdlpKIKGa 141
Cdd:cd00254     1 PALVLAVIRVESGFNPRA-----VSPAGARGLMQLMpgtaRDLGRRGVDDLFDPEENIRAGARYLRELLD-----RFGG- 69

                          90
                  ....*....|....*..
gi 2753373729 142 gpeiieNWYFPIMAYNG 158
Cdd:cd00254    70 ------DLELALAAYNA 80
SH3_3 pfam08239
Bacterial SH3 domain;
250-310 4.49e-07

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 46.47  E-value: 4.49e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2753373729 250 VNLRSKPNTSSSVVSVLAKGTNVTIdgdfLYDQSLAdnpfvWYPVKTADQKlVGYISSAYV 310
Cdd:pfam08239   3 LNVRSGPSTSSEVVGTLPKGEKVEV----LEEQGGG-----WYKVRTYDGY-EGWVSSSYL 53
SH3b smart00287
Bacterial SH3 domain homologues;
241-276 3.77e-05

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 41.16  E-value: 3.77e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2753373729  241 DNVVVTGNEVNLRSKPNTSSSVVSVLAKGTNVTIDG 276
Cdd:smart00287   2 ETAVVTGDGLNVRTGPGTSSPIIGTLKKGDKVKVLG 37
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 61-180 2.09e-03

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 40.43  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  61 DAKIPPEVVKAVAKQESSWRQFVNgqpfiSQDGGIGLMQIT-----------NKPSYDQQKLKYDIKYNIQAGIEILNNM 129
Cdd:PRK11619  489 GKGIPQSYAMAIARQESAWNPKAR-----SPVGASGLMQIMpgtathtvkmfSIPGYSSSSQLLDPETNINIGTSYLEYV 563

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2753373729 130 Y-SWGdlpkikgagpeiiENWYFPIMAYN-GIKPINSPLKQSTGERNPIAYQE 180
Cdd:PRK11619  564 YqQFG-------------NNRILASAAYNaGPGRVRTWLGNSAGRIDAVAFVE 603
Y_Y_Y pfam07495
Y_Y_Y domain; This domain is mostly found at the end of the beta propellers (pfam07494) in a ...
 345-402 5.34e-03

Y_Y_Y domain; This domain is mostly found at the end of the beta propellers (pfam07494) in a family of two component regulators. However they are also found tandemly repeated in Swiss:Q891H4 without other signal conduction domains being present. It's named after the conserved tyrosines found in the alignment. The exact function is not known.


Pssm-ID: 400051 [Multi-domain]  Cd Length: 65  Bit Score: 35.41  E-value: 5.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 345 EGSNQPQYKFNV--YDGNtWKVVQDYSdksTYVWKPEKAGTYKFSVHAKDANSQTAYDSY 402
Cdd:pfam07495   3 DGPENLLYRYRLegFDGE-WVELGDYS---EASYTNLPPGKYTLKVKAKDNDGNWSYDDA 58
 
Name Accession Description Interval E-value
PRK14081 PRK14081
triple tyrosine motif-containing protein; Provisional
 311-410 2.00e-10

triple tyrosine motif-containing protein; Provisional


Pssm-ID: 237602 [Multi-domain]  Cd Length: 667  Bit Score: 62.75  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 311 IKVKKAEKVNNVKVVTDKVGPQsIGTPITLTATSEGSNQPQYKFNVYDGNTWKVVQDYSDKSTYVWKPEKAGTYKFSVHA 390
Cdd:PRK14081  569 FYVREALPITNTKIKTSKKKFK-CNEEVTFSVKSEGGKDVCYEFYIMEKGEWKLVQKYSRKNYYSFMPFNKGKYKVLVLC 647

                          90       100
                  ....*....|....*....|
gi 2753373729 391 KDANSQTAYDSYYAFDYKVE 410
Cdd:PRK14081  648 KSYYKKCAYEDYDIFEFKVE 667
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 54-158 2.71e-10

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 60.39  E-value: 2.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  54 LLTSAALDAKIPPEVVKAVAKQESSWRQFVngqpfISQDGGIGLMQItnKPS-----------YDQQKLKYDIKYNIQAG 122
Cdd:COG0741   106 LIEEAAKKYGVDPALVLALIRQESAFNPNA-----VSPAGARGLMQL--MPAtarrlglklglGPSPDDLFDPETNIRAG 178

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2753373729 123 IEILNNMYSwgdlpKIKGagpeiieNWYFPIMAYNG 158
Cdd:COG0741   179 AAYLRELLD-----RFDG-------DLVLALAAYNA 202
PRK14081 PRK14081
triple tyrosine motif-containing protein; Provisional
 295-424 3.22e-10

triple tyrosine motif-containing protein; Provisional


Pssm-ID: 237602 [Multi-domain]  Cd Length: 667  Bit Score: 61.98  E-value: 3.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 295 KTADQKLVGYISSAYVIK-----------VKKAEKVNNVKVVTDKVGPQSIGTPITLTATSEGSNQPQYKFNVyDGntwK 363
Cdd:PRK14081  254 KSGDYKLLCLVKDMYSNNefddravlvytVKPYKDIKIRNFTTDLSSPQLTDTDIELKAVAEGGKELLYRFII-KG---K 329

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2753373729 364 VVQD--YSDKSTYVWKPEKAGTYKFSVHAKDANSQTAYDSYYAFDYKVEGGK---VSKVNVITDKE 424
Cdd:PRK14081  330 ESEDsgYIRNNIYTWKPKIAGKYSITLWVKDISSKGEYEDKSSIDYTIEEKSkepIKIEDVILDKG 395
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
243-310 9.24e-10

Uncharacterized conserved protein YraI [Function unknown];


Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 55.07  E-value: 9.24e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2753373729 243 VVVTGNEVNLRSKPNTSSSVVSVLAKGTNVTIDGdflydqSLADNPfvWYPVKTADQKlvGYISSAYV 310
Cdd:COG4991    24 TAVATDDLNLRSGPGTGYPVVGTLPAGATVTVLG------CTSGGG--WCKVSYGGQR--GWVSARYL 81
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 64-178 2.71e-09

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 54.62  E-value: 2.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  64 IPPEVVKAVAKQESSWrqfvngQPF-ISQDGGIGLMQI---TNKPSYDQQKLKYDIKY----NIQAGIEILNNMYSWGDl 135
Cdd:pfam01464  10 VDPSLLLAIAQQESGF------NPKaVSKSGAVGLMQImpsTAKRLGLRVNPGVDDLFdpekNIKAGTKYLKELYKQYG- 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2753373729 136 pkikgagpeiiENWYFPIMAYN-GIKPINSPLKQsTGERNPIAY 178
Cdd:pfam01464  83 -----------GDLWLALAAYNaGPGRVRKWIKN-AGAKDKKLL 114
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 243-324 1.57e-08

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 52.43  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 243 VVVTGNEVNLRSKPNTSSSVVSVLAKGTNVTIDGDflydqslADNpfvWYPVKTADQKlVGYISSAYVIKVKKAEKVNNV 322
Cdd:COG3103     7 YVVDADALNVRSGPGTSYRIVGTLPKGEKVTVLGR-------SGG---WYKVRYSNGK-TGWVSSRYLTVTPSARERLPD 75


                  ..
gi 2753373729 323 KV 324
Cdd:COG3103    76 EL 77
PRK14081 PRK14081
triple tyrosine motif-containing protein; Provisional
 327-424 3.08e-08

triple tyrosine motif-containing protein; Provisional


Pssm-ID: 237602 [Multi-domain]  Cd Length: 667  Bit Score: 55.81  E-value: 3.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 327 DKVGPQSIGTPITLTATSEGSNQPQYKFNVYDGNTWKVVQDYSDKSTYVWKPEKAGTYKFSVHAKDANSQTAYDSYYAFD 406
Cdd:PRK14081    9 DKESPQEKNSEINIKIINNPNDKLLYKFIIGKNGIWNTIRDFSKEDEINWIPKEEGEYTIMVQAKKEDSNKPFDYVSKED 88

                          90
                  ....*....|....*....
gi 2753373729 407 YKVEGGKVSKV-NVITDKE 424
Cdd:PRK14081   89 YVIGKAEEKLIkNIYLDKD 107
PRK14081 PRK14081
triple tyrosine motif-containing protein; Provisional
 286-409 4.98e-08

triple tyrosine motif-containing protein; Provisional


Pssm-ID: 237602 [Multi-domain]  Cd Length: 667  Bit Score: 55.04  E-value: 4.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 286 DNPFVWYPVKTADQKLVGY---ISSA----------YVIKVKKAEKVNNVKVVTDKVGPQSIGTPITLTATSEGSNQPQY 352
Cdd:PRK14081  339 NNIYTWKPKIAGKYSITLWvkdISSKgeyedkssidYTIEEKSKEPIKIEDVILDKGKHILKGEEIKIRVIAEGGTNLRY 418

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2753373729 353 KFNVYDGNTWKVVQDYSDKSTYVWKPEKAGTYKFSVHAKDANSQTAYDSYYAFDYKV 409
Cdd:PRK14081  419 SFIIKKDGKEEEKIDYGKNNWVNFIPEEKGNYELEVRVKDKYSDKEYDAHTIVYIKV 475
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 66-158 1.60e-07

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 49.52  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  66 PEVVKAVAKQESSWRQFVngqpfISQDGGIGLMQIT----NKPSYDQQKLKYDIKYNIQAGIEILNNMYSwgdlpKIKGa 141
Cdd:cd00254     1 PALVLAVIRVESGFNPRA-----VSPAGARGLMQLMpgtaRDLGRRGVDDLFDPEENIRAGARYLRELLD-----RFGG- 69

                          90
                  ....*....|....*..
gi 2753373729 142 gpeiieNWYFPIMAYNG 158
Cdd:cd00254    70 ------DLELALAAYNA 80
SH3_3 pfam08239
Bacterial SH3 domain;
250-310 4.49e-07

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 46.47  E-value: 4.49e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2753373729 250 VNLRSKPNTSSSVVSVLAKGTNVTIdgdfLYDQSLAdnpfvWYPVKTADQKlVGYISSAYV 310
Cdd:pfam08239   3 LNVRSGPSTSSEVVGTLPKGEKVEV----LEEQGGG-----WYKVRTYDGY-EGWVSSSYL 53
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 64-187 6.43e-07

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 47.52  E-value: 6.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  64 IPPEVVKAVAKQESSWRQFVNGQpfiSQDGG--IGLMQI-------TNKPSYDQQKLKYDIKYNIQAGIEIL-NNMYSWG 133
Cdd:cd13400     3 VPPRLLRAIAKVESGFNPNAINR---NKNGSydIGLMQInsiwlpeLARYGITREELLNDPCTNIYVGAWILaRNIKRYG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2753373729 134 DLPkiKGAGpeiienwyfpimAYNGIKPinsplkqstgeRNPIAYQEKVFPIIE 187
Cdd:cd13400    80 NTW--KAVG------------AYNSGTP-----------KKNDKYARKVYRIYR 108
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 54-158 1.26e-06

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 47.86  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  54 LLTSAALDAKIPPEVVKAVAKQESSWRQFVngqpfISQDGGIGLMQI-----------TNKPSYDQQKLkYDIKYNIQAG 122
Cdd:cd13401     9 LVERAAKKNGLDPALVYAIIRQESAFDPDA-----VSPAGALGLMQLmpatakdvakkLGLPYYSPRDL-FDPEYNIRLG 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2753373729 123 IEILNNMY-SWGDlpkikgagpeiieNWYFPIMAYNG 158
Cdd:cd13401    83 SAYLAELLdRFDG-------------NPVLALAAYNA 106
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 57-158 1.15e-05

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 44.81  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  57 SAALDAKIPPEVVKAVAKQESSWRQFVngqpfISQDGGIGLMQIT-----------NKPSYDQQKLkYDIKYNIQAGIEI 125
Cdd:cd16896    10 KYAKEYGVDPLLVAAVIKVESNFNPNA-----VSSKGAIGLMQIMpetaewiaeklGLEDFSEDDL-YDPETNIRLGTWY 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2753373729 126 LNNMYS--WGDLPKIkgagpeiienwyfpIMAYNG 158
Cdd:cd16896    84 LSYLLKefDGNLVLA--------------LAAYNA 104
SH3b smart00287
Bacterial SH3 domain homologues;
241-276 3.77e-05

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 41.16  E-value: 3.77e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2753373729  241 DNVVVTGNEVNLRSKPNTSSSVVSVLAKGTNVTIDG 276
Cdd:smart00287   2 ETAVVTGDGLNVRTGPGTSSPIIGTLKKGDKVKVLG 37
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 58-158 4.93e-05

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 43.32  E-value: 4.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  58 AALDAKIPPEVVKAVAKQESSwrqfvnGQPF-ISQDGGIGLMQItnKPS------YDQQKLK---------YDIKYNIQA 121
Cdd:cd16893     6 YAKKYGVDPALILAIIETESS------FNPYaVSHSPAYGLMQI--VPStagrdvYRLLGGKgglpsksylFDPENNIDI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2753373729 122 G---IEILNNMYswgdLPKIKgaGPEIIEnwYFPIMAYNG 158
Cdd:cd16893    78 GtayLHILQNRY----LKGIK--NPKSRE--YCAIAAYNG 109
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 54-158 2.18e-04

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 43.13  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  54 LLTSAALDAKIPPEVVKAVAKQESSWRQFVngqpfISQDGGIGLMQITnKPSYDQQKLK--YDIKYNIQAGIEILNNMYS 131
Cdd:COG4623   267 LFEKYAEEYGLDWRLLAALAYQESHWNPRA-----RSPTGARGLMQLM-PATAKELGVDdrLDPEQSIRAGAKYLRWLYD 340

                          90       100
                  ....*....|....*....|....*..
gi 2753373729 132 wgdlpKIKGAGPEiIENWYFPIMAYNG 158
Cdd:COG4623   341 -----RFPEAIDE-PDRWWFALAAYNA 361
SH3 COG3807
SH3-like domain [Function unknown];
242-320 5.18e-04

SH3-like domain [Function unknown];


Pssm-ID: 443020 [Multi-domain]  Cd Length: 150  Bit Score: 40.27  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 242 NVVVTGNEVNLRSKPNTSSSVVSVLAKGTNVTI---DGDflydqsladnpfvWYPVKTADQKlvGYISSAYVIKVKKAEK 318
Cdd:COG3807    84 TVIVTGDLANLRASPDENAAVVARLEPGVVLRLlecDGG-------------WCKVRADGYK--GWVRQSLLWGVYPGEI 148


                  ..
gi 2753373729 319 VN 320
Cdd:COG3807   149 ID 150
PRK14081 PRK14081
triple tyrosine motif-containing protein; Provisional
 352-409 1.13e-03

triple tyrosine motif-containing protein; Provisional


Pssm-ID: 237602 [Multi-domain]  Cd Length: 667  Bit Score: 41.18  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2753373729 352 YKFNVYDGNTWKVVQDYSDKSTYVWKPEKAGTYKFSVHAKDANSQTAYDSYYAFDYKV 409
Cdd:PRK14081  128 YRYWIKEDNNWKLIKDYSTENSLSYTANKPGKYELLVECKRIDSTKDFDDFKKVKFKV 185
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 61-180 2.09e-03

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 40.43  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729  61 DAKIPPEVVKAVAKQESSWRQFVNgqpfiSQDGGIGLMQIT-----------NKPSYDQQKLKYDIKYNIQAGIEILNNM 129
Cdd:PRK11619  489 GKGIPQSYAMAIARQESAWNPKAR-----SPVGASGLMQIMpgtathtvkmfSIPGYSSSSQLLDPETNINIGTSYLEYV 563

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2753373729 130 Y-SWGdlpkikgagpeiiENWYFPIMAYN-GIKPINSPLKQSTGERNPIAYQE 180
Cdd:PRK11619  564 YqQFG-------------NNRILASAAYNaGPGRVRTWLGNSAGRIDAVAFVE 603
Y_Y_Y pfam07495
Y_Y_Y domain; This domain is mostly found at the end of the beta propellers (pfam07494) in a ...
 345-402 5.34e-03

Y_Y_Y domain; This domain is mostly found at the end of the beta propellers (pfam07494) in a family of two component regulators. However they are also found tandemly repeated in Swiss:Q891H4 without other signal conduction domains being present. It's named after the conserved tyrosines found in the alignment. The exact function is not known.


Pssm-ID: 400051 [Multi-domain]  Cd Length: 65  Bit Score: 35.41  E-value: 5.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753373729 345 EGSNQPQYKFNV--YDGNtWKVVQDYSdksTYVWKPEKAGTYKFSVHAKDANSQTAYDSY 402
Cdd:pfam07495   3 DGPENLLYRYRLegFDGE-WVELGDYS---EASYTNLPPGKYTLKVKAKDNDGNWSYDDA 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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