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Conserved domains on  [gi|2755143487|ref|WP_354190440|]
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fibronectin type III domain-containing protein [Arthrobacter sp. UYCu712]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EEP super family cl00490
Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes ...
 309-607 2.20e-33

Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes the catalytic domain (exonuclease/endonuclease/phosphatase or EEP domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps proteins.


The actual alignment was detected with superfamily member cd09083:

Pssm-ID: 469791 [Multi-domain]  Cd Length: 252  Bit Score: 128.10  E-value: 2.20e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 309 SVASFNIHCFTCVDGmpeEKSWAERRAAVVQTIVSKMPDIIGVQEAsqtwLDNrpggytQFEDLRDRLtaagGAYKLTDS 388
Cdd:cd09083     1 RVMTFNIRYDNPSDG---ENSWENRKDLVAELIKFYDPDIIGTQEA----LPH------QLADLEELL----PEYDWIGV 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 389 DRNncvdsrlptncvyADKGASAGTKIFYNANTVKLIRSGSK---ELPAVAA-----ADIPRFVAWAEAVQLSTGKHVFF 460
Cdd:cd09083    64 GRD-------------DGKEKGEFSAIFYRKDRFELLDSGTFwlsETPDVVGskgwdAALPRICTWARFKDKKTGKEFYV 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 461 ADAHLE-IGKDAasndlRKRQAQTVMDTIKSKNTGaLPVILVSDMNSnkwtEPANGPYDVITSQGLVDplgntfkSWyps 539
Cdd:cd09083   131 FNTHLDhVGEEA-----REESAKLILERIKEIAGD-LPVILTGDFNA----EPDSEPYKTLTSGGLKD-------AR--- 190

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755143487 540 gaATAEKVVNRRVNSWNGFERavrqgaaGTSGAYIDYIFTSK-MRVTYYEnvakIDAlGNYVGTFASDH 607
Cdd:cd09083   191 --DTAATTDGGPEGTFHGFKG-------PPGGSRIDYIFVSPgVKVLSYE----ILT-DRYDGRYPSDH 245
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
13-315 6.39e-17

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 84.28  E-value: 6.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  13 SAVAATAPPTGLKTTSQTTSNYLSMSWNPVTGGVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLTPSTTYYVMVKALNS 92
Cdd:COG3401   135 AATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDT 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  93 AGAdlTAYSAAVAAKTLPAQPAPPTGLKATSQTSNYLTMGWNAVT--GAVGYRLMYSTKSDMSapfYRNIASGTTGG--Y 168
Cdd:COG3401   215 GGE--SAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTesDATGYRVYRSNSGDGP---FTKVATVTTTSytD 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 169 GGLTPSTTYYVMVKALNSAGaDLTAYSPPVTAKTLVAPPTPPTGLKSTAQSTTTLAFSWGAVADAPQ-----YRLALSSK 243
Cdd:COG3401   290 TGLTNGTTYYYRVTAVDAAG-NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADVtgynvYRSTSGGG 368

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2755143487 244 SDMSSPSYLTTTSASGEmrGLSPATAYYAQVRVISATGAgITSYSPVVKATTAAVPVLPAVANPLSVASFNI 315
Cdd:COG3401   369 TYTKIAETVTTTSYTDT--GLTPGTTYYYKVTAVDAAGN-ESAPSEEVSATTASAASGESLTASVDAVPLTD 437
 
Name Accession Description Interval E-value
EEP-1 cd09083
Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of ...
 309-607 2.20e-33

Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.


Pssm-ID: 197317 [Multi-domain]  Cd Length: 252  Bit Score: 128.10  E-value: 2.20e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 309 SVASFNIHCFTCVDGmpeEKSWAERRAAVVQTIVSKMPDIIGVQEAsqtwLDNrpggytQFEDLRDRLtaagGAYKLTDS 388
Cdd:cd09083     1 RVMTFNIRYDNPSDG---ENSWENRKDLVAELIKFYDPDIIGTQEA----LPH------QLADLEELL----PEYDWIGV 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 389 DRNncvdsrlptncvyADKGASAGTKIFYNANTVKLIRSGSK---ELPAVAA-----ADIPRFVAWAEAVQLSTGKHVFF 460
Cdd:cd09083    64 GRD-------------DGKEKGEFSAIFYRKDRFELLDSGTFwlsETPDVVGskgwdAALPRICTWARFKDKKTGKEFYV 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 461 ADAHLE-IGKDAasndlRKRQAQTVMDTIKSKNTGaLPVILVSDMNSnkwtEPANGPYDVITSQGLVDplgntfkSWyps 539
Cdd:cd09083   131 FNTHLDhVGEEA-----REESAKLILERIKEIAGD-LPVILTGDFNA----EPDSEPYKTLTSGGLKD-------AR--- 190

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755143487 540 gaATAEKVVNRRVNSWNGFERavrqgaaGTSGAYIDYIFTSK-MRVTYYEnvakIDAlGNYVGTFASDH 607
Cdd:cd09083   191 --DTAATTDGGPEGTFHGFKG-------PPGGSRIDYIFVSPgVKVLSYE----ILT-DRYDGRYPSDH 245
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
13-315 6.39e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 84.28  E-value: 6.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  13 SAVAATAPPTGLKTTSQTTSNYLSMSWNPVTGGVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLTPSTTYYVMVKALNS 92
Cdd:COG3401   135 AATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDT 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  93 AGAdlTAYSAAVAAKTLPAQPAPPTGLKATSQTSNYLTMGWNAVT--GAVGYRLMYSTKSDMSapfYRNIASGTTGG--Y 168
Cdd:COG3401   215 GGE--SAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTesDATGYRVYRSNSGDGP---FTKVATVTTTSytD 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 169 GGLTPSTTYYVMVKALNSAGaDLTAYSPPVTAKTLVAPPTPPTGLKSTAQSTTTLAFSWGAVADAPQ-----YRLALSSK 243
Cdd:COG3401   290 TGLTNGTTYYYRVTAVDAAG-NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADVtgynvYRSTSGGG 368

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2755143487 244 SDMSSPSYLTTTSASGEmrGLSPATAYYAQVRVISATGAgITSYSPVVKATTAAVPVLPAVANPLSVASFNI 315
Cdd:COG3401   369 TYTKIAETVTTTSYTDT--GLTPGTTYYYKVTAVDAAGN-ESAPSEEVSATTASAASGESLTASVDAVPLTD 437
COG2374 COG2374
Predicted extracellular nuclease [General function prediction only];
277-529 3.76e-15

Predicted extracellular nuclease [General function prediction only];


Pssm-ID: 441941 [Multi-domain]  Cd Length: 362  Bit Score: 77.37  E-value: 3.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 277 ISATGAGITSYSPVVKATTAAVPVLPaVANPLSVASFNIH-CFTCVD-------GMPEEKSWAERRAAVVQTIVSKMPDI 348
Cdd:COG2374    39 LGLTGVLFGNYRQPTETFVNPRPEAP-VGGDLRVATFNVEnLFDTDDddddfgrGADTPEEYERKLAKIAAAIAALDADI 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 349 IGVQEasqtwLDNRPggyTQFEDLRDRLTAAGGAYKLTDSDRNNcvDSRLPTNCvyadkgasagtkIFYNANTVKLIRSG 428
Cdd:COG2374   118 VGLQE-----VENNG---SALQDLVAALNLAGGTYAFVHPPDGP--DGDGIRVA------------LLYRPDRVTLVGSA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 429 SKELPAVAAADIPRF-----VAwaeAVQLSTGKHVFFADAHL-------EIGKDAASNDLRKRQAQTV---MDTIKSKNT 493
Cdd:COG2374   176 TIADLPDSPGNPDRFsrpplAV---TFELANGEPFTVIVNHFkskgsddPGDGQGASEAKRTAQAEALrafVDSLLAADP 252

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2755143487 494 GAlPVILVSDMNSnkwtEPANGPYDVITSQ-GLVDPL 529
Cdd:COG2374   253 DA-PVIVLGDFND----YPFEDPLRALLGAgGLTNLA 284
fn3 pfam00041
Fibronectin type III domain;
115-188 5.75e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 5.75e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755143487 115 PPTGLKATSQTSNYLTMGWNAVTGA----VGYRLMYSTKSDMSAPFYRNIASGTTGGYGGL-TPSTTYYVMVKALNSAG 188
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlKPGTEYEVRVQAVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 207-295 6.74e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 207 PTPPTGLKSTAQSTTTLAFSWGAVADAP--------QYRLALSSKSDMSSPSYLTTTSAsgEMRGLSPATAYyaQVRVIS 278
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGgpitgyvvEYREKGSGDWKEVEVTPGSETSY--TLTGLKPGTEY--EFRVRA 76

                          90
                  ....*....|....*..
gi 2755143487 279 ATGAGITSYSPVVKATT 295
Cdd:cd00063    77 VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 113-188 2.88e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 2.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  113 PAPPTGLKATSQTSNYLTMGWNAV--TGAVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLT---PSTTYYVMVKALNSA 187
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTglkPGTEYEFRVRAVNGA 80


                   .
gi 2755143487  188 G 188
Cdd:smart00060  81 G 81
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 190-282 4.20e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 40.22  E-value: 4.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  190 DLTAYSPPVTAK----------TLVAPPTPPTGLKSTAQSTTTLAFSWGAVADAPQYRlalsskSDMSSPSYLTTTSASG 259
Cdd:PHA03309    91 DLFAFSDPTSASpqpvpmdaslSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWR------PVHGPSWWLSSSSPSG 164

                           90       100
                   ....*....|....*....|...
gi 2755143487  260 EMRGLSPATAYYAQVRVISATGA 282
Cdd:PHA03309   165 SSRGSVTSPQYSGEETSDAASGA 187
 
Name Accession Description Interval E-value
EEP-1 cd09083
Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of ...
 309-607 2.20e-33

Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.


Pssm-ID: 197317 [Multi-domain]  Cd Length: 252  Bit Score: 128.10  E-value: 2.20e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 309 SVASFNIHCFTCVDGmpeEKSWAERRAAVVQTIVSKMPDIIGVQEAsqtwLDNrpggytQFEDLRDRLtaagGAYKLTDS 388
Cdd:cd09083     1 RVMTFNIRYDNPSDG---ENSWENRKDLVAELIKFYDPDIIGTQEA----LPH------QLADLEELL----PEYDWIGV 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 389 DRNncvdsrlptncvyADKGASAGTKIFYNANTVKLIRSGSK---ELPAVAA-----ADIPRFVAWAEAVQLSTGKHVFF 460
Cdd:cd09083    64 GRD-------------DGKEKGEFSAIFYRKDRFELLDSGTFwlsETPDVVGskgwdAALPRICTWARFKDKKTGKEFYV 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 461 ADAHLE-IGKDAasndlRKRQAQTVMDTIKSKNTGaLPVILVSDMNSnkwtEPANGPYDVITSQGLVDplgntfkSWyps 539
Cdd:cd09083   131 FNTHLDhVGEEA-----REESAKLILERIKEIAGD-LPVILTGDFNA----EPDSEPYKTLTSGGLKD-------AR--- 190

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755143487 540 gaATAEKVVNRRVNSWNGFERavrqgaaGTSGAYIDYIFTSK-MRVTYYEnvakIDAlGNYVGTFASDH 607
Cdd:cd09083   191 --DTAATTDGGPEGTFHGFKG-------PPGGSRIDYIFVSPgVKVLSYE----ILT-DRYDGRYPSDH 245
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
13-315 6.39e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 84.28  E-value: 6.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  13 SAVAATAPPTGLKTTSQTTSNYLSMSWNPVTGGVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLTPSTTYYVMVKALNS 92
Cdd:COG3401   135 AATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDT 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  93 AGAdlTAYSAAVAAKTLPAQPAPPTGLKATSQTSNYLTMGWNAVT--GAVGYRLMYSTKSDMSapfYRNIASGTTGG--Y 168
Cdd:COG3401   215 GGE--SAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTesDATGYRVYRSNSGDGP---FTKVATVTTTSytD 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 169 GGLTPSTTYYVMVKALNSAGaDLTAYSPPVTAKTLVAPPTPPTGLKSTAQSTTTLAFSWGAVADAPQ-----YRLALSSK 243
Cdd:COG3401   290 TGLTNGTTYYYRVTAVDAAG-NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADVtgynvYRSTSGGG 368

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2755143487 244 SDMSSPSYLTTTSASGEmrGLSPATAYYAQVRVISATGAgITSYSPVVKATTAAVPVLPAVANPLSVASFNI 315
Cdd:COG3401   369 TYTKIAETVTTTSYTDT--GLTPGTTYYYKVTAVDAAGN-ESAPSEEVSATTASAASGESLTASVDAVPLTD 437
COG2374 COG2374
Predicted extracellular nuclease [General function prediction only];
277-529 3.76e-15

Predicted extracellular nuclease [General function prediction only];


Pssm-ID: 441941 [Multi-domain]  Cd Length: 362  Bit Score: 77.37  E-value: 3.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 277 ISATGAGITSYSPVVKATTAAVPVLPaVANPLSVASFNIH-CFTCVD-------GMPEEKSWAERRAAVVQTIVSKMPDI 348
Cdd:COG2374    39 LGLTGVLFGNYRQPTETFVNPRPEAP-VGGDLRVATFNVEnLFDTDDddddfgrGADTPEEYERKLAKIAAAIAALDADI 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 349 IGVQEasqtwLDNRPggyTQFEDLRDRLTAAGGAYKLTDSDRNNcvDSRLPTNCvyadkgasagtkIFYNANTVKLIRSG 428
Cdd:COG2374   118 VGLQE-----VENNG---SALQDLVAALNLAGGTYAFVHPPDGP--DGDGIRVA------------LLYRPDRVTLVGSA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 429 SKELPAVAAADIPRF-----VAwaeAVQLSTGKHVFFADAHL-------EIGKDAASNDLRKRQAQTV---MDTIKSKNT 493
Cdd:COG2374   176 TIADLPDSPGNPDRFsrpplAV---TFELANGEPFTVIVNHFkskgsddPGDGQGASEAKRTAQAEALrafVDSLLAADP 252

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2755143487 494 GAlPVILVSDMNSnkwtEPANGPYDVITSQ-GLVDPL 529
Cdd:COG2374   253 DA-PVIVLGDFND----YPFEDPLRALLGAgGLTNLA 284
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
19-307 4.74e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.42  E-value: 4.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  19 APPTGLKTTSqTTSNYLSMSWNPVT--GGVGYRLMYSTKSDMSapfYRNIASGTTGG--YGGLTPSTTYYVMVKALNSAG 94
Cdd:COG3401   234 SAPTGLTATA-DTPGSVTLSWDPVTesDATGYRVYRSNSGDGP---FTKVATVTTTSytDTGLTNGTTYYYRVTAVDAAG 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  95 aDLTAYSAAVAAKTLPAQPAPPTGLKATSQTSNYLTMGWNAVTG--AVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLT 172
Cdd:COG3401   310 -NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLT 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 173 PSTTYYVMVKALNSAGaDLTAYSPPVTAKTLVAPPTPPTGL-KSTAQSTTTLAFSWGAVADAPQYRLALSSKSDMSSPSY 251
Cdd:COG3401   389 PGTTYYYKVTAVDAAG-NESAPSEEVSATTASAASGESLTAsVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNA 467

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2755143487 252 LTTTSASGEMRGLSPATAYYAQVRVISATGAGITSYSPVVKATTAAVPVLPAVANP 307
Cdd:COG3401   468 VPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGA 523
ElsH COG3568
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ...
 302-617 6.35e-09

Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only];


Pssm-ID: 442789 [Multi-domain]  Cd Length: 167  Bit Score: 55.30  E-value: 6.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 302 PAVANPLSVASFNIHCFTCVDGMpeekswaERRAAVVQTIVSKMPDIIGVQEasqtwldnrpggytqfedlrdrltaagg 381
Cdd:COG3568     2 AAAAATLRVMTYNIRYGLGTDGR-------ADLERIARVIRALDPDVVALQE---------------------------- 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 382 aykltdsdrnNCVDSRLPtncvyadkgasagtkifynantvkLIRSGSKELPAVAAAdiPRFVAWAEaVQLsTGKHVFFA 461
Cdd:COG3568    47 ----------NAILSRYP------------------------IVSSGTFDLPDPGGE--PRGALWAD-VDV-PGKPLRVV 88

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 462 DAHLeigkDAASNDLRKRQAQTVMDTIKSKNTGAlPVILVSDMNSnkwtepangpydvitsqglvdplgntfkswypsga 541
Cdd:COG3568    89 NTHL----DLRSAAARRRQARALAELLAELPAGA-PVILAGDFND----------------------------------- 128

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2755143487 542 ataekvvnrrvnswngferavrqgaagtsgayIDYIFTSK-MRVTYYENVAKIDalgnyvGTFASDHNMQFATVGLP 617
Cdd:COG3568   129 --------------------------------IDYILVSPgLRVLSAEVLDSPL------GRAASDHLPVVADLELP 167
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
15-299 6.17e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 55.78  E-value: 6.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  15 VAATAPPTGLKTTSQTTSNYLSMSWNPVTGGVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLTPSTTYYVMVKALNSAG 94
Cdd:COG3401    43 VLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  95 ADLTAYSAAVAAKTLPAQPAPPTGLKATSQTSNYLTMGWNAVTGAVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLTPS 174
Cdd:COG3401   123 GTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 175 TTYYVMVKALNSAGAdlTAYSPPVTAKTLVAPPTPPTGLKSTAQSTTTLAFSWGAVA--DAPQYRLALSSKSDMSSPSYL 252
Cdd:COG3401   203 TTYYYRVAATDTGGE--SAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTesDATGYRVYRSNSGDGPFTKVA 280

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2755143487 253 TTTSASGEMRGLSPATAYYAQVRVISATGAgITSYSPVVKATTAAVP 299
Cdd:COG3401   281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGN-ESAPSNVVSVTTDLTP 326
fn3 pfam00041
Fibronectin type III domain;
115-188 5.75e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 5.75e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755143487 115 PPTGLKATSQTSNYLTMGWNAVTGA----VGYRLMYSTKSDMSAPFYRNIASGTTGGYGGL-TPSTTYYVMVKALNSAG 188
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlKPGTEYEVRVQAVNGGG 80
fn3 pfam00041
Fibronectin type III domain;
20-94 4.66e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.02  E-value: 4.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  20 PPTGLkTTSQTTSNYLSMSWNPVTGG----VGYRLMYSTKSDMSAPFYRNIASGTTGGYGGL-TPSTTYYVMVKALNSAG 94
Cdd:pfam00041   2 APSNL-TVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlKPGTEYEVRVQAVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 207-295 6.74e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 207 PTPPTGLKSTAQSTTTLAFSWGAVADAP--------QYRLALSSKSDMSSPSYLTTTSAsgEMRGLSPATAYyaQVRVIS 278
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGgpitgyvvEYREKGSGDWKEVEVTPGSETSY--TLTGLKPGTEY--EFRVRA 76

                          90
                  ....*....|....*..
gi 2755143487 279 ATGAGITSYSPVVKATT 295
Cdd:cd00063    77 VNGGGESPPSESVTVTT 93
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
10-308 7.06e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 46.09  E-value: 7.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  10 GTQSAVAATAPPTGLKTTSQTTS-------NYLSMSWNPVTGGVGYRLMYSTksdmSAPFYRNIA-SGTTGGYGGLTPST 81
Cdd:COG4733   522 GAFDDVPPQWPPVNVTTSESLSVvaqgtavTTLTVSWDAPAGAVAYEVEWRR----DDGNWVSVPrTSGTSFEVPGIYAG 597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  82 TYYVMVKALNSAG-ADLTAYSAAVAAKTLPAQPAPPTGLKATSQTsNYLTMGWNAVTGA--VGYRLMYSTKSDM-SAPFY 157
Cdd:COG4733   598 DYEVRVRAINALGvSSAWAASSETTVTGKTAPPPAPTGLTATGGL-GGITLSWSFPVDAdtLRTEIRYSTTGDWaSATVA 676

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 158 RNIASGTTGGYGGLTPSTTYYVMVKALNSAGaDLTAYSPPVTAKTLVAPPTPPTGLKSTAQSTTTLAFS------WGAVA 231
Cdd:COG4733   677 QALYPGNTYTLAGLKAGQTYYYRARAVDRSG-NVSAWWVSGQASADAAGILDAITGQILETELGQELDAiiqnatVAEVV 755

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2755143487 232 DAPQYRLALSSKSDMSSPSYLTTTSASGEMRGLSPATAYYAQVRVISATGAGITSYSPVVKATTAAVPVLPAVANPL 308
Cdd:COG4733   756 AATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDASGGVTAGTSGTTGAGDTAAST 832
Deadenylase_nocturnin cd09096
C-terminal deadenylase domain of nocturnin and related domains; This subfamily contains the ...
 329-581 2.34e-04

C-terminal deadenylase domain of nocturnin and related domains; This subfamily contains the C-terminal catalytic domain of the deadenylase, nocturnin, and related domains. Nocturnin is a poly(A)-specific 3' exonuclease that specifically degrades the 3' poly(A) tail of RNA in a process known as deadenylation. This nuclease activity is manganese dependent. Nocturnin is expressed in the cytoplasm of Xenopus laevis retinal photoreceptor cells in a rhythmic fashion, and it has been proposed that it participates in posttranscriptional regulation of the circadian clock or its outputs, and that the mRNA target(s) of this deadenylase are circadian clock-related. In mouse, the nocturnin gene, mNoc, is expressed in a circadian pattern in a range of tissues including retina, spleen, heart, kidney, and liver. It is highly expressed in bone-marrow stromal cells, adipocytes and hepatocytes. In mammals, nocturnin plays a role in regulating mesenchymal stem-cell lineage allocation, perhaps through regulating PPAR-gamma (peroxisome proliferator-activated receptor-gamma) nuclear translocation. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197330 [Multi-domain]  Cd Length: 280  Bit Score: 43.57  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 329 SWAERRAAVVQTIVSKMPDIIGVQEASQTwldnrpggYTQFEDLRDRLTAAGGAYKLTDSDRNNCVDSRLPTNCVyadkg 408
Cdd:cd09096    28 KWEERKYLILEEILTYDPDILCLQEVDHY--------KDTLQPLLSRLGYQGTFFPKPDSPCLYIENNNGPDGCA----- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 409 asagtkIFYNANTVKLIRSGSKELPAVAAADipRFVAWAEAVQLS-TGKHVFFADAHLEIGKDAASndLRKRQAQTVMDT 487
Cdd:cd09096    95 ------LFFRKDRFELVNTEKIRLSAMTLKT--NQVAIACTLRCKeTGREICLAVTHLKARTGWER--LRSEQGKDLLQN 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 488 IKSKNTGA-LPVILVSDMNSnkwtEPANGPYDVITSQGLvdPLGNTFKSWYPSGAATAEkvvnrrVNSWNgferaVRQga 566
Cdd:cd09096   165 LQSFIEGAkIPLIICGDFNA----EPTEPVYKTFSNSSL--NLNSAYKLLSADGQSEPP------YTTWK-----IRT-- 225

                         250
                  ....*....|....*
gi 2755143487 567 AGTSGAYIDYIFTSK 581
Cdd:cd09096   226 SGECRHTLDYIFYSK 240
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 113-188 2.88e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 2.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  113 PAPPTGLKATSQTSNYLTMGWNAV--TGAVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLT---PSTTYYVMVKALNSA 187
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTglkPGTEYEFRVRAVNGA 80


                   .
gi 2755143487  188 G 188
Cdd:smart00060  81 G 81
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
129-344 4.14e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.40  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 129 LTMGWNAVTGAVGYRLMYSTksdmSAPFYRNIA-SGTTGGYGGLTPSTTYYVMVKALNSAG-ADLTAYSPPVTAKTLVAP 206
Cdd:COG4733   554 LTVSWDAPAGAVAYEVEWRR----DDGNWVSVPrTSGTSFEVPGIYAGDYEVRVRAINALGvSSAWAASSETTVTGKTAP 629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 207 PTPPTGLKSTAqSTTTLAFSWGAVADAPQ-----YRLALSSKSDMSSPSYLTTTSASgEMRGLSPATAYYAQVRVISATG 281
Cdd:COG4733   630 PPAPTGLTATG-GLGGITLSWSFPVDADTlrteiRYSTTGDWASATVAQALYPGNTY-TLAGLKAGQTYYYRARAVDRSG 707

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2755143487 282 agitSYSPVVkATTAAVPVLPAVANPLSVASFNIHCFTCVDGMPEEKSWAERRAAVVQTIVSK 344
Cdd:COG4733   708 ----NVSAWW-VSGQASADAAGILDAITGQILETELGQELDAIIQNATVAEVVAATVTDVTAQ 765
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 207-283 4.26e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 4.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  207 PTPPTGLKSTAQSTTTLAFSWGAVADAP------QYRLALSSKSDMSSPSYLTTTSASGEMRGLSPATAYYAQVRVISAT 280
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitgyivGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 2755143487  281 GAG 283
Cdd:smart00060  81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 113-202 5.24e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 113 PAPPTGLKATSQTSNYLTMGWNAVTGA----VGYRLMYSTKSDMSapfYRNIASGTTGGYGGL----TPSTTYYVMVKAL 184
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggpiTGYVVEYREKGSGD---WKEVEVTPGSETSYTltglKPGTEYEFRVRAV 77

                          90
                  ....*....|....*...
gi 2755143487 185 NSAGadLTAYSPPVTAKT 202
Cdd:cd00063    78 NGGG--ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 20-94 1.94e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 1.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487   20 PPTGLKTTSqTTSNYLSMSWNPV--TGGVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLT---PSTTYYVMVKALNSAG 94
Cdd:smart00060   3 PPSNLRVTD-VTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTglkPGTEYEFRVRAVNGAG 81
nSMase cd09078
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological ...
 308-607 2.51e-03

Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Sphingomyelinases (SMase) are phosphodiesterases that catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Eukaryotic SMases have been classified according to their pH optima and are known as acid SMase, alkaline SMase, and neutral SMase (nSMase). Eukaryotic proteins in this family are nSMases, and are activated by a variety of stress-inducing agents such as cytokines or UV radiation. Ceramides and other metabolic derivatives, including sphingosine, are lipid "second messenger" molecules that participate in the regulation of stress-induced cellular responses, including cell death, adhesion, differentiation, and proliferation. Bacterial neutral SMases, which also belong to this domain family, are secreted proteins that act as membrane-damaging virulence factors. They promote colonization of the host tissue. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197312 [Multi-domain]  Cd Length: 280  Bit Score: 40.02  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 308 LSVASFNIHCFTcvDGMPEEKSW--AERRAAVVQTIvsKMPDIIGVQEASqtwlDNRpggytqfedLRDRLTAAGGA--- 382
Cdd:cd09078     1 LKVLTYNVFLLP--PLLYNNGDDgqDERLDLIPKAL--LQYDVVVLQEVF----DAR---------ARKRLLNGLKKeyp 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 383 --YKLTDSDRNNC----VD------SRLP---------TNCVYADKGASAGtkifynANTVKLIRSGSKELpavaaadip 441
Cdd:cd09078    64 yqTDVVGRSPSGWssklVDggvvilSRYPivekdqyifPNGCGADCLAAKG------VLYAKINKGGTKVY--------- 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 442 rfvawaeavqlstgkHVFfaDAHLE-IGKDAASNDLRKRQAQTVMDTIKSKNTGA-LPVILVSDMNSNKWTEPANgPYDV 519
Cdd:cd09078   129 ---------------HVF--GTHLQaSDGSCLDRAVRQKQLDELRAFIEEKNIPDnEPVIIAGDFNVDKRSSRDE-YDDM 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 520 ITSqgLVDPLGNTfkswyPSGAATAEKvvnrrvnSWNGFERAVRQGAAGTSGA-YIDYIFTSKM--RVTYYEN------V 590
Cdd:cd09078   191 LEQ--LHDYNAPE-----PITAGETPL-------TWDPGTNLLAKYNYPGGGGeRLDYILYSNDhlQPSSWSNevevpkS 256

                         330
                  ....*....|....*..
gi 2755143487 591 AKIDALGNYVGTFASDH 607
Cdd:cd09078   257 PTWSVTNGYTFADLSDH 273
fn3 pfam00041
Fibronectin type III domain;
209-288 3.97e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 36.62  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 209 PPTGLKSTAQSTTTLAFSWGAVADAP----QYRLALSSKSDMSSPSYLTTTSASGEM--RGLSPATAYyaQVRVISATGA 282
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNgpitGYEVEYRPKNSGEPWNEITVPGTTTSVtlTGLKPGTEY--EVRVQAVNGG 79


                  ....*.
gi 2755143487 283 GITSYS 288
Cdd:pfam00041  80 GEGPPS 85
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 190-282 4.20e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 40.22  E-value: 4.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487  190 DLTAYSPPVTAK----------TLVAPPTPPTGLKSTAQSTTTLAFSWGAVADAPQYRlalsskSDMSSPSYLTTTSASG 259
Cdd:PHA03309    91 DLFAFSDPTSASpqpvpmdaslSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWR------PVHGPSWWLSSSSPSG 164

                           90       100
                   ....*....|....*....|...
gi 2755143487  260 EMRGLSPATAYYAQVRVISATGA 282
Cdd:PHA03309   165 SSRGSVTSPQYSGEETSDAASGA 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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