|
Name |
Accession |
Description |
Interval |
E-value |
| EEP-1 |
cd09083 |
Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of ... |
309-607 |
2.20e-33 |
|
Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.
Pssm-ID: 197317 [Multi-domain] Cd Length: 252 Bit Score: 128.10 E-value: 2.20e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 309 SVASFNIHCFTCVDGmpeEKSWAERRAAVVQTIVSKMPDIIGVQEAsqtwLDNrpggytQFEDLRDRLtaagGAYKLTDS 388
Cdd:cd09083 1 RVMTFNIRYDNPSDG---ENSWENRKDLVAELIKFYDPDIIGTQEA----LPH------QLADLEELL----PEYDWIGV 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 389 DRNncvdsrlptncvyADKGASAGTKIFYNANTVKLIRSGSK---ELPAVAA-----ADIPRFVAWAEAVQLSTGKHVFF 460
Cdd:cd09083 64 GRD-------------DGKEKGEFSAIFYRKDRFELLDSGTFwlsETPDVVGskgwdAALPRICTWARFKDKKTGKEFYV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 461 ADAHLE-IGKDAasndlRKRQAQTVMDTIKSKNTGaLPVILVSDMNSnkwtEPANGPYDVITSQGLVDplgntfkSWyps 539
Cdd:cd09083 131 FNTHLDhVGEEA-----REESAKLILERIKEIAGD-LPVILTGDFNA----EPDSEPYKTLTSGGLKD-------AR--- 190
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755143487 540 gaATAEKVVNRRVNSWNGFERavrqgaaGTSGAYIDYIFTSK-MRVTYYEnvakIDAlGNYVGTFASDH 607
Cdd:cd09083 191 --DTAATTDGGPEGTFHGFKG-------PPGGSRIDYIFVSPgVKVLSYE----ILT-DRYDGRYPSDH 245
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
13-315 |
6.39e-17 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 84.28 E-value: 6.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 13 SAVAATAPPTGLKTTSQTTSNYLSMSWNPVTGGVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLTPSTTYYVMVKALNS 92
Cdd:COG3401 135 AATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDT 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 93 AGAdlTAYSAAVAAKTLPAQPAPPTGLKATSQTSNYLTMGWNAVT--GAVGYRLMYSTKSDMSapfYRNIASGTTGG--Y 168
Cdd:COG3401 215 GGE--SAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTesDATGYRVYRSNSGDGP---FTKVATVTTTSytD 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 169 GGLTPSTTYYVMVKALNSAGaDLTAYSPPVTAKTLVAPPTPPTGLKSTAQSTTTLAFSWGAVADAPQ-----YRLALSSK 243
Cdd:COG3401 290 TGLTNGTTYYYRVTAVDAAG-NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADVtgynvYRSTSGGG 368
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2755143487 244 SDMSSPSYLTTTSASGEmrGLSPATAYYAQVRVISATGAgITSYSPVVKATTAAVPVLPAVANPLSVASFNI 315
Cdd:COG3401 369 TYTKIAETVTTTSYTDT--GLTPGTTYYYKVTAVDAAGN-ESAPSEEVSATTASAASGESLTASVDAVPLTD 437
|
|
| COG2374 |
COG2374 |
Predicted extracellular nuclease [General function prediction only]; |
277-529 |
3.76e-15 |
|
Predicted extracellular nuclease [General function prediction only];
Pssm-ID: 441941 [Multi-domain] Cd Length: 362 Bit Score: 77.37 E-value: 3.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 277 ISATGAGITSYSPVVKATTAAVPVLPaVANPLSVASFNIH-CFTCVD-------GMPEEKSWAERRAAVVQTIVSKMPDI 348
Cdd:COG2374 39 LGLTGVLFGNYRQPTETFVNPRPEAP-VGGDLRVATFNVEnLFDTDDddddfgrGADTPEEYERKLAKIAAAIAALDADI 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 349 IGVQEasqtwLDNRPggyTQFEDLRDRLTAAGGAYKLTDSDRNNcvDSRLPTNCvyadkgasagtkIFYNANTVKLIRSG 428
Cdd:COG2374 118 VGLQE-----VENNG---SALQDLVAALNLAGGTYAFVHPPDGP--DGDGIRVA------------LLYRPDRVTLVGSA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 429 SKELPAVAAADIPRF-----VAwaeAVQLSTGKHVFFADAHL-------EIGKDAASNDLRKRQAQTV---MDTIKSKNT 493
Cdd:COG2374 176 TIADLPDSPGNPDRFsrpplAV---TFELANGEPFTVIVNHFkskgsddPGDGQGASEAKRTAQAEALrafVDSLLAADP 252
|
250 260 270
....*....|....*....|....*....|....*..
gi 2755143487 494 GAlPVILVSDMNSnkwtEPANGPYDVITSQ-GLVDPL 529
Cdd:COG2374 253 DA-PVIVLGDFND----YPFEDPLRALLGAgGLTNLA 284
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
115-188 |
5.75e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 44.71 E-value: 5.75e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755143487 115 PPTGLKATSQTSNYLTMGWNAVTGA----VGYRLMYSTKSDMSAPFYRNIASGTTGGYGGL-TPSTTYYVMVKALNSAG 188
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
207-295 |
6.74e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 42.10 E-value: 6.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 207 PTPPTGLKSTAQSTTTLAFSWGAVADAP--------QYRLALSSKSDMSSPSYLTTTSAsgEMRGLSPATAYyaQVRVIS 278
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGgpitgyvvEYREKGSGDWKEVEVTPGSETSY--TLTGLKPGTEY--EFRVRA 76
|
90
....*....|....*..
gi 2755143487 279 ATGAGITSYSPVVKATT 295
Cdd:cd00063 77 VNGGGESPPSESVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
113-188 |
2.88e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.91 E-value: 2.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 113 PAPPTGLKATSQTSNYLTMGWNAV--TGAVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLT---PSTTYYVMVKALNSA 187
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTglkPGTEYEFRVRAVNGA 80
|
.
gi 2755143487 188 G 188
Cdd:smart00060 81 G 81
|
|
| PHA03309 |
PHA03309 |
transcriptional regulator ICP4; Provisional |
190-282 |
4.20e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 165564 [Multi-domain] Cd Length: 2033 Bit Score: 40.22 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 190 DLTAYSPPVTAK----------TLVAPPTPPTGLKSTAQSTTTLAFSWGAVADAPQYRlalsskSDMSSPSYLTTTSASG 259
Cdd:PHA03309 91 DLFAFSDPTSASpqpvpmdaslSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWR------PVHGPSWWLSSSSPSG 164
|
90 100
....*....|....*....|...
gi 2755143487 260 EMRGLSPATAYYAQVRVISATGA 282
Cdd:PHA03309 165 SSRGSVTSPQYSGEETSDAASGA 187
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| EEP-1 |
cd09083 |
Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of ... |
309-607 |
2.20e-33 |
|
Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.
Pssm-ID: 197317 [Multi-domain] Cd Length: 252 Bit Score: 128.10 E-value: 2.20e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 309 SVASFNIHCFTCVDGmpeEKSWAERRAAVVQTIVSKMPDIIGVQEAsqtwLDNrpggytQFEDLRDRLtaagGAYKLTDS 388
Cdd:cd09083 1 RVMTFNIRYDNPSDG---ENSWENRKDLVAELIKFYDPDIIGTQEA----LPH------QLADLEELL----PEYDWIGV 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 389 DRNncvdsrlptncvyADKGASAGTKIFYNANTVKLIRSGSK---ELPAVAA-----ADIPRFVAWAEAVQLSTGKHVFF 460
Cdd:cd09083 64 GRD-------------DGKEKGEFSAIFYRKDRFELLDSGTFwlsETPDVVGskgwdAALPRICTWARFKDKKTGKEFYV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 461 ADAHLE-IGKDAasndlRKRQAQTVMDTIKSKNTGaLPVILVSDMNSnkwtEPANGPYDVITSQGLVDplgntfkSWyps 539
Cdd:cd09083 131 FNTHLDhVGEEA-----REESAKLILERIKEIAGD-LPVILTGDFNA----EPDSEPYKTLTSGGLKD-------AR--- 190
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755143487 540 gaATAEKVVNRRVNSWNGFERavrqgaaGTSGAYIDYIFTSK-MRVTYYEnvakIDAlGNYVGTFASDH 607
Cdd:cd09083 191 --DTAATTDGGPEGTFHGFKG-------PPGGSRIDYIFVSPgVKVLSYE----ILT-DRYDGRYPSDH 245
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
13-315 |
6.39e-17 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 84.28 E-value: 6.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 13 SAVAATAPPTGLKTTSQTTSNYLSMSWNPVTGGVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLTPSTTYYVMVKALNS 92
Cdd:COG3401 135 AATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDT 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 93 AGAdlTAYSAAVAAKTLPAQPAPPTGLKATSQTSNYLTMGWNAVT--GAVGYRLMYSTKSDMSapfYRNIASGTTGG--Y 168
Cdd:COG3401 215 GGE--SAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTesDATGYRVYRSNSGDGP---FTKVATVTTTSytD 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 169 GGLTPSTTYYVMVKALNSAGaDLTAYSPPVTAKTLVAPPTPPTGLKSTAQSTTTLAFSWGAVADAPQ-----YRLALSSK 243
Cdd:COG3401 290 TGLTNGTTYYYRVTAVDAAG-NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADVtgynvYRSTSGGG 368
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2755143487 244 SDMSSPSYLTTTSASGEmrGLSPATAYYAQVRVISATGAgITSYSPVVKATTAAVPVLPAVANPLSVASFNI 315
Cdd:COG3401 369 TYTKIAETVTTTSYTDT--GLTPGTTYYYKVTAVDAAGN-ESAPSEEVSATTASAASGESLTASVDAVPLTD 437
|
|
| COG2374 |
COG2374 |
Predicted extracellular nuclease [General function prediction only]; |
277-529 |
3.76e-15 |
|
Predicted extracellular nuclease [General function prediction only];
Pssm-ID: 441941 [Multi-domain] Cd Length: 362 Bit Score: 77.37 E-value: 3.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 277 ISATGAGITSYSPVVKATTAAVPVLPaVANPLSVASFNIH-CFTCVD-------GMPEEKSWAERRAAVVQTIVSKMPDI 348
Cdd:COG2374 39 LGLTGVLFGNYRQPTETFVNPRPEAP-VGGDLRVATFNVEnLFDTDDddddfgrGADTPEEYERKLAKIAAAIAALDADI 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 349 IGVQEasqtwLDNRPggyTQFEDLRDRLTAAGGAYKLTDSDRNNcvDSRLPTNCvyadkgasagtkIFYNANTVKLIRSG 428
Cdd:COG2374 118 VGLQE-----VENNG---SALQDLVAALNLAGGTYAFVHPPDGP--DGDGIRVA------------LLYRPDRVTLVGSA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 429 SKELPAVAAADIPRF-----VAwaeAVQLSTGKHVFFADAHL-------EIGKDAASNDLRKRQAQTV---MDTIKSKNT 493
Cdd:COG2374 176 TIADLPDSPGNPDRFsrpplAV---TFELANGEPFTVIVNHFkskgsddPGDGQGASEAKRTAQAEALrafVDSLLAADP 252
|
250 260 270
....*....|....*....|....*....|....*..
gi 2755143487 494 GAlPVILVSDMNSnkwtEPANGPYDVITSQ-GLVDPL 529
Cdd:COG2374 253 DA-PVIVLGDFND----YPFEDPLRALLGAgGLTNLA 284
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
19-307 |
4.74e-14 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 75.42 E-value: 4.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 19 APPTGLKTTSqTTSNYLSMSWNPVT--GGVGYRLMYSTKSDMSapfYRNIASGTTGG--YGGLTPSTTYYVMVKALNSAG 94
Cdd:COG3401 234 SAPTGLTATA-DTPGSVTLSWDPVTesDATGYRVYRSNSGDGP---FTKVATVTTTSytDTGLTNGTTYYYRVTAVDAAG 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 95 aDLTAYSAAVAAKTLPAQPAPPTGLKATSQTSNYLTMGWNAVTG--AVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLT 172
Cdd:COG3401 310 -NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLT 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 173 PSTTYYVMVKALNSAGaDLTAYSPPVTAKTLVAPPTPPTGL-KSTAQSTTTLAFSWGAVADAPQYRLALSSKSDMSSPSY 251
Cdd:COG3401 389 PGTTYYYKVTAVDAAG-NESAPSEEVSATTASAASGESLTAsVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNA 467
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2755143487 252 LTTTSASGEMRGLSPATAYYAQVRVISATGAGITSYSPVVKATTAAVPVLPAVANP 307
Cdd:COG3401 468 VPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGA 523
|
|
| ElsH |
COG3568 |
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ... |
302-617 |
6.35e-09 |
|
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only];
Pssm-ID: 442789 [Multi-domain] Cd Length: 167 Bit Score: 55.30 E-value: 6.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 302 PAVANPLSVASFNIHCFTCVDGMpeekswaERRAAVVQTIVSKMPDIIGVQEasqtwldnrpggytqfedlrdrltaagg 381
Cdd:COG3568 2 AAAAATLRVMTYNIRYGLGTDGR-------ADLERIARVIRALDPDVVALQE---------------------------- 46
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 382 aykltdsdrnNCVDSRLPtncvyadkgasagtkifynantvkLIRSGSKELPAVAAAdiPRFVAWAEaVQLsTGKHVFFA 461
Cdd:COG3568 47 ----------NAILSRYP------------------------IVSSGTFDLPDPGGE--PRGALWAD-VDV-PGKPLRVV 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 462 DAHLeigkDAASNDLRKRQAQTVMDTIKSKNTGAlPVILVSDMNSnkwtepangpydvitsqglvdplgntfkswypsga 541
Cdd:COG3568 89 NTHL----DLRSAAARRRQARALAELLAELPAGA-PVILAGDFND----------------------------------- 128
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2755143487 542 ataekvvnrrvnswngferavrqgaagtsgayIDYIFTSK-MRVTYYENVAKIDalgnyvGTFASDHNMQFATVGLP 617
Cdd:COG3568 129 --------------------------------IDYILVSPgLRVLSAEVLDSPL------GRAASDHLPVVADLELP 167
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
15-299 |
6.17e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 55.78 E-value: 6.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 15 VAATAPPTGLKTTSQTTSNYLSMSWNPVTGGVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLTPSTTYYVMVKALNSAG 94
Cdd:COG3401 43 VLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 95 ADLTAYSAAVAAKTLPAQPAPPTGLKATSQTSNYLTMGWNAVTGAVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLTPS 174
Cdd:COG3401 123 GTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPG 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 175 TTYYVMVKALNSAGAdlTAYSPPVTAKTLVAPPTPPTGLKSTAQSTTTLAFSWGAVA--DAPQYRLALSSKSDMSSPSYL 252
Cdd:COG3401 203 TTYYYRVAATDTGGE--SAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTesDATGYRVYRSNSGDGPFTKVA 280
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2755143487 253 TTTSASGEMRGLSPATAYYAQVRVISATGAgITSYSPVVKATTAAVP 299
Cdd:COG3401 281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGN-ESAPSNVVSVTTDLTP 326
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
115-188 |
5.75e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 44.71 E-value: 5.75e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755143487 115 PPTGLKATSQTSNYLTMGWNAVTGA----VGYRLMYSTKSDMSAPFYRNIASGTTGGYGGL-TPSTTYYVMVKALNSAG 188
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlKPGTEYEVRVQAVNGGG 80
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
20-94 |
4.66e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 42.02 E-value: 4.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 20 PPTGLkTTSQTTSNYLSMSWNPVTGG----VGYRLMYSTKSDMSAPFYRNIASGTTGGYGGL-TPSTTYYVMVKALNSAG 94
Cdd:pfam00041 2 APSNL-TVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
207-295 |
6.74e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 42.10 E-value: 6.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 207 PTPPTGLKSTAQSTTTLAFSWGAVADAP--------QYRLALSSKSDMSSPSYLTTTSAsgEMRGLSPATAYyaQVRVIS 278
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGgpitgyvvEYREKGSGDWKEVEVTPGSETSY--TLTGLKPGTEY--EFRVRA 76
|
90
....*....|....*..
gi 2755143487 279 ATGAGITSYSPVVKATT 295
Cdd:cd00063 77 VNGGGESPPSESVTVTT 93
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
10-308 |
7.06e-05 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 46.09 E-value: 7.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 10 GTQSAVAATAPPTGLKTTSQTTS-------NYLSMSWNPVTGGVGYRLMYSTksdmSAPFYRNIA-SGTTGGYGGLTPST 81
Cdd:COG4733 522 GAFDDVPPQWPPVNVTTSESLSVvaqgtavTTLTVSWDAPAGAVAYEVEWRR----DDGNWVSVPrTSGTSFEVPGIYAG 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 82 TYYVMVKALNSAG-ADLTAYSAAVAAKTLPAQPAPPTGLKATSQTsNYLTMGWNAVTGA--VGYRLMYSTKSDM-SAPFY 157
Cdd:COG4733 598 DYEVRVRAINALGvSSAWAASSETTVTGKTAPPPAPTGLTATGGL-GGITLSWSFPVDAdtLRTEIRYSTTGDWaSATVA 676
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 158 RNIASGTTGGYGGLTPSTTYYVMVKALNSAGaDLTAYSPPVTAKTLVAPPTPPTGLKSTAQSTTTLAFS------WGAVA 231
Cdd:COG4733 677 QALYPGNTYTLAGLKAGQTYYYRARAVDRSG-NVSAWWVSGQASADAAGILDAITGQILETELGQELDAiiqnatVAEVV 755
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2755143487 232 DAPQYRLALSSKSDMSSPSYLTTTSASGEMRGLSPATAYYAQVRVISATGAGITSYSPVVKATTAAVPVLPAVANPL 308
Cdd:COG4733 756 AATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDASGGVTAGTSGTTGAGDTAAST 832
|
|
| Deadenylase_nocturnin |
cd09096 |
C-terminal deadenylase domain of nocturnin and related domains; This subfamily contains the ... |
329-581 |
2.34e-04 |
|
C-terminal deadenylase domain of nocturnin and related domains; This subfamily contains the C-terminal catalytic domain of the deadenylase, nocturnin, and related domains. Nocturnin is a poly(A)-specific 3' exonuclease that specifically degrades the 3' poly(A) tail of RNA in a process known as deadenylation. This nuclease activity is manganese dependent. Nocturnin is expressed in the cytoplasm of Xenopus laevis retinal photoreceptor cells in a rhythmic fashion, and it has been proposed that it participates in posttranscriptional regulation of the circadian clock or its outputs, and that the mRNA target(s) of this deadenylase are circadian clock-related. In mouse, the nocturnin gene, mNoc, is expressed in a circadian pattern in a range of tissues including retina, spleen, heart, kidney, and liver. It is highly expressed in bone-marrow stromal cells, adipocytes and hepatocytes. In mammals, nocturnin plays a role in regulating mesenchymal stem-cell lineage allocation, perhaps through regulating PPAR-gamma (peroxisome proliferator-activated receptor-gamma) nuclear translocation. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.
Pssm-ID: 197330 [Multi-domain] Cd Length: 280 Bit Score: 43.57 E-value: 2.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 329 SWAERRAAVVQTIVSKMPDIIGVQEASQTwldnrpggYTQFEDLRDRLTAAGGAYKLTDSDRNNCVDSRLPTNCVyadkg 408
Cdd:cd09096 28 KWEERKYLILEEILTYDPDILCLQEVDHY--------KDTLQPLLSRLGYQGTFFPKPDSPCLYIENNNGPDGCA----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 409 asagtkIFYNANTVKLIRSGSKELPAVAAADipRFVAWAEAVQLS-TGKHVFFADAHLEIGKDAASndLRKRQAQTVMDT 487
Cdd:cd09096 95 ------LFFRKDRFELVNTEKIRLSAMTLKT--NQVAIACTLRCKeTGREICLAVTHLKARTGWER--LRSEQGKDLLQN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 488 IKSKNTGA-LPVILVSDMNSnkwtEPANGPYDVITSQGLvdPLGNTFKSWYPSGAATAEkvvnrrVNSWNgferaVRQga 566
Cdd:cd09096 165 LQSFIEGAkIPLIICGDFNA----EPTEPVYKTFSNSSL--NLNSAYKLLSADGQSEPP------YTTWK-----IRT-- 225
|
250
....*....|....*
gi 2755143487 567 AGTSGAYIDYIFTSK 581
Cdd:cd09096 226 SGECRHTLDYIFYSK 240
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
113-188 |
2.88e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.91 E-value: 2.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 113 PAPPTGLKATSQTSNYLTMGWNAV--TGAVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLT---PSTTYYVMVKALNSA 187
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTglkPGTEYEFRVRAVNGA 80
|
.
gi 2755143487 188 G 188
Cdd:smart00060 81 G 81
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
129-344 |
4.14e-04 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 43.40 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 129 LTMGWNAVTGAVGYRLMYSTksdmSAPFYRNIA-SGTTGGYGGLTPSTTYYVMVKALNSAG-ADLTAYSPPVTAKTLVAP 206
Cdd:COG4733 554 LTVSWDAPAGAVAYEVEWRR----DDGNWVSVPrTSGTSFEVPGIYAGDYEVRVRAINALGvSSAWAASSETTVTGKTAP 629
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 207 PTPPTGLKSTAqSTTTLAFSWGAVADAPQ-----YRLALSSKSDMSSPSYLTTTSASgEMRGLSPATAYYAQVRVISATG 281
Cdd:COG4733 630 PPAPTGLTATG-GLGGITLSWSFPVDADTlrteiRYSTTGDWASATVAQALYPGNTY-TLAGLKAGQTYYYRARAVDRSG 707
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2755143487 282 agitSYSPVVkATTAAVPVLPAVANPLSVASFNIHCFTCVDGMPEEKSWAERRAAVVQTIVSK 344
Cdd:COG4733 708 ----NVSAWW-VSGQASADAAGILDAITGQILETELGQELDAIIQNATVAEVVAATVTDVTAQ 765
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
207-283 |
4.26e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.52 E-value: 4.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 207 PTPPTGLKSTAQSTTTLAFSWGAVADAP------QYRLALSSKSDMSSPSYLTTTSASGEMRGLSPATAYYAQVRVISAT 280
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitgyivGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 2755143487 281 GAG 283
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
113-202 |
5.24e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 39.40 E-value: 5.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 113 PAPPTGLKATSQTSNYLTMGWNAVTGA----VGYRLMYSTKSDMSapfYRNIASGTTGGYGGL----TPSTTYYVMVKAL 184
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggpiTGYVVEYREKGSGD---WKEVEVTPGSETSYTltglKPGTEYEFRVRAV 77
|
90
....*....|....*...
gi 2755143487 185 NSAGadLTAYSPPVTAKT 202
Cdd:cd00063 78 NGGG--ESPPSESVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
20-94 |
1.94e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 37.59 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 20 PPTGLKTTSqTTSNYLSMSWNPV--TGGVGYRLMYSTKSDMSAPFYRNIASGTTGGYGGLT---PSTTYYVMVKALNSAG 94
Cdd:smart00060 3 PPSNLRVTD-VTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTglkPGTEYEFRVRAVNGAG 81
|
|
| nSMase |
cd09078 |
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological ... |
308-607 |
2.51e-03 |
|
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Sphingomyelinases (SMase) are phosphodiesterases that catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Eukaryotic SMases have been classified according to their pH optima and are known as acid SMase, alkaline SMase, and neutral SMase (nSMase). Eukaryotic proteins in this family are nSMases, and are activated by a variety of stress-inducing agents such as cytokines or UV radiation. Ceramides and other metabolic derivatives, including sphingosine, are lipid "second messenger" molecules that participate in the regulation of stress-induced cellular responses, including cell death, adhesion, differentiation, and proliferation. Bacterial neutral SMases, which also belong to this domain family, are secreted proteins that act as membrane-damaging virulence factors. They promote colonization of the host tissue. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.
Pssm-ID: 197312 [Multi-domain] Cd Length: 280 Bit Score: 40.02 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 308 LSVASFNIHCFTcvDGMPEEKSW--AERRAAVVQTIvsKMPDIIGVQEASqtwlDNRpggytqfedLRDRLTAAGGA--- 382
Cdd:cd09078 1 LKVLTYNVFLLP--PLLYNNGDDgqDERLDLIPKAL--LQYDVVVLQEVF----DAR---------ARKRLLNGLKKeyp 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 383 --YKLTDSDRNNC----VD------SRLP---------TNCVYADKGASAGtkifynANTVKLIRSGSKELpavaaadip 441
Cdd:cd09078 64 yqTDVVGRSPSGWssklVDggvvilSRYPivekdqyifPNGCGADCLAAKG------VLYAKINKGGTKVY--------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 442 rfvawaeavqlstgkHVFfaDAHLE-IGKDAASNDLRKRQAQTVMDTIKSKNTGA-LPVILVSDMNSNKWTEPANgPYDV 519
Cdd:cd09078 129 ---------------HVF--GTHLQaSDGSCLDRAVRQKQLDELRAFIEEKNIPDnEPVIIAGDFNVDKRSSRDE-YDDM 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 520 ITSqgLVDPLGNTfkswyPSGAATAEKvvnrrvnSWNGFERAVRQGAAGTSGA-YIDYIFTSKM--RVTYYEN------V 590
Cdd:cd09078 191 LEQ--LHDYNAPE-----PITAGETPL-------TWDPGTNLLAKYNYPGGGGeRLDYILYSNDhlQPSSWSNevevpkS 256
|
330
....*....|....*..
gi 2755143487 591 AKIDALGNYVGTFASDH 607
Cdd:cd09078 257 PTWSVTNGYTFADLSDH 273
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
209-288 |
3.97e-03 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 36.62 E-value: 3.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 209 PPTGLKSTAQSTTTLAFSWGAVADAP----QYRLALSSKSDMSSPSYLTTTSASGEM--RGLSPATAYyaQVRVISATGA 282
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPPPDGNgpitGYEVEYRPKNSGEPWNEITVPGTTTSVtlTGLKPGTEY--EVRVQAVNGG 79
|
....*.
gi 2755143487 283 GITSYS 288
Cdd:pfam00041 80 GEGPPS 85
|
|
| PHA03309 |
PHA03309 |
transcriptional regulator ICP4; Provisional |
190-282 |
4.20e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 165564 [Multi-domain] Cd Length: 2033 Bit Score: 40.22 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755143487 190 DLTAYSPPVTAK----------TLVAPPTPPTGLKSTAQSTTTLAFSWGAVADAPQYRlalsskSDMSSPSYLTTTSASG 259
Cdd:PHA03309 91 DLFAFSDPTSASpqpvpmdaslSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWR------PVHGPSWWLSSSSPSG 164
|
90 100
....*....|....*....|...
gi 2755143487 260 EMRGLSPATAYYAQVRVISATGA 282
Cdd:PHA03309 165 SSRGSVTSPQYSGEETSDAASGA 187
|
|
|