NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2755728385|ref|WP_354619747|]
View 

MULTISPECIES: transglycosylase SLT domain-containing protein [Gammaproteobacteria]

Protein Classification

lysozyme family protein( domain architecture ID 63)

lysozyme family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Lyz-like super family cl00222
lysozyme-like domains; This family contains several members, including soluble lytic ...
 36-173 1.20e-15

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


The actual alignment was detected with superfamily member cd13400:

Pssm-ID: 469668 [Multi-domain]  Cd Length: 109  Bit Score: 68.71  E-value: 1.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  36 YNLDPLLVYSVALAESA------SGRGNGSIspwpwtlrvpglpfyaksedqakaklaefqqqygraiDVGFMQVSIRWN 109
Cdd:cd13400     1 YGVPPRLLRAIAKVESGfnpnaiNRNKNGSY-------------------------------------DIGLMQINSIWL 43

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2755728385 110 G----HRVSSPADLLDPETNVMVGAEVLSEAIQSSpNDLELGVGRYHAWEDEIRARnYGSRVLAIYRN 173
Cdd:cd13400    44 PelarYGITREELLNDPCTNIYVGAWILARNIKRY-GNTWKAVGAYNSGTPKKNDK-YARKVYRIYRR 109
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 36-173 1.20e-15

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 68.71  E-value: 1.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  36 YNLDPLLVYSVALAESA------SGRGNGSIspwpwtlrvpglpfyaksedqakaklaefqqqygraiDVGFMQVSIRWN 109
Cdd:cd13400     1 YGVPPRLLRAIAKVESGfnpnaiNRNKNGSY-------------------------------------DIGLMQINSIWL 43

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2755728385 110 G----HRVSSPADLLDPETNVMVGAEVLSEAIQSSpNDLELGVGRYHAWEDEIRARnYGSRVLAIYRN 173
Cdd:cd13400    44 PelarYGITREELLNDPCTNIYVGAWILARNIKRY-GNTWKAVGAYNSGTPKKNDK-YARKVYRIYRR 109
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 29-153 1.30e-07

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 47.69  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  29 FDKAAKAYNLDPLLVYSVALAESAsgrgngsispwpwtlrvpGLPfYAKSedqakaklaefqqqygRAIDVGFMQV---S 105
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESG------------------FNP-KAVS----------------KSGAVGLMQImpsT 45

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2755728385 106 IRWNGHRV-SSPADLLDPETNVMVGAEVLSEAIQSSPNDLELGVGRYHA 153
Cdd:pfam01464  46 AKRLGLRVnPGVDDLFDPEKNIKAGTKYLKELYKQYGGDLWLALAAYNA 94
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 28-175 1.64e-07

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 49.61  E-value: 1.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  28 IFDKAAKAYNLDPLLVYSVALAESAsgrgngsispwpwtlrvpglpF--YAKSedQAKAklaefqqqygraidVGFMQV- 104
Cdd:COG0741   106 LIEEAAKKYGVDPALVLALIRQESA---------------------FnpNAVS--PAGA--------------RGLMQLm 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385 105 --SIRWNGHRV---SSPADLLDPETNVMVGAEVLSEAIQSSPNDLEL-------GVGRYHAWEDEIRA-----------R 161
Cdd:COG0741   149 paTARRLGLKLglgPSPDDLFDPETNIRAGAAYLRELLDRFDGDLVLalaaynaGPGRVRRWLRRNGDrdgeiipyaetR 228

                         170
                  ....*....|....
gi 2755728385 162 NYGSRVLAIYRNLR 175
Cdd:COG0741   229 NYVKKVLANYAIYR 242
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 36-173 1.20e-15

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 68.71  E-value: 1.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  36 YNLDPLLVYSVALAESA------SGRGNGSIspwpwtlrvpglpfyaksedqakaklaefqqqygraiDVGFMQVSIRWN 109
Cdd:cd13400     1 YGVPPRLLRAIAKVESGfnpnaiNRNKNGSY-------------------------------------DIGLMQINSIWL 43

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2755728385 110 G----HRVSSPADLLDPETNVMVGAEVLSEAIQSSpNDLELGVGRYHAWEDEIRARnYGSRVLAIYRN 173
Cdd:cd13400    44 PelarYGITREELLNDPCTNIYVGAWILARNIKRY-GNTWKAVGAYNSGTPKKNDK-YARKVYRIYRR 109
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 29-153 1.30e-07

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 47.69  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  29 FDKAAKAYNLDPLLVYSVALAESAsgrgngsispwpwtlrvpGLPfYAKSedqakaklaefqqqygRAIDVGFMQV---S 105
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESG------------------FNP-KAVS----------------KSGAVGLMQImpsT 45

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2755728385 106 IRWNGHRV-SSPADLLDPETNVMVGAEVLSEAIQSSPNDLELGVGRYHA 153
Cdd:pfam01464  46 AKRLGLRVnPGVDDLFDPEKNIKAGTKYLKELYKQYGGDLWLALAAYNA 94
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 28-175 1.64e-07

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 49.61  E-value: 1.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  28 IFDKAAKAYNLDPLLVYSVALAESAsgrgngsispwpwtlrvpglpF--YAKSedQAKAklaefqqqygraidVGFMQV- 104
Cdd:COG0741   106 LIEEAAKKYGVDPALVLALIRQESA---------------------FnpNAVS--PAGA--------------RGLMQLm 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385 105 --SIRWNGHRV---SSPADLLDPETNVMVGAEVLSEAIQSSPNDLEL-------GVGRYHAWEDEIRA-----------R 161
Cdd:COG0741   149 paTARRLGLKLglgPSPDDLFDPETNIRAGAAYLRELLDRFDGDLVLalaaynaGPGRVRRWLRRNGDrdgeiipyaetR 228

                         170
                  ....*....|....
gi 2755728385 162 NYGSRVLAIYRNLR 175
Cdd:COG0741   229 NYVKKVLANYAIYR 242
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 35-136 1.32e-06

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 45.61  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  35 AYNLDPLLVYSVALAESasgRGNgsispwPWTLRV--PGLPFYAKSEDQAKAKLAEFQQQyGRAIDVGFMQVSIR-WNGH 111
Cdd:cd16892     6 APGVHPETLAAIVQVES---GGN------PYAIGVngGKLSRQPKTKAEAIATARQLIAA-GHNFDVGLGQINSRnLARL 75

                          90       100
                  ....*....|....*....|....*
gi 2755728385 112 RVSsPADLLDPETNVMVGAEVLSEA 136
Cdd:cd16892    76 GLT-VEDVFDPCTNLKAGATILTEC 99
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 28-174 7.32e-06

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 43.62  E-value: 7.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  28 IFDKAAKAYNLDPLLVYSVALAESAsgrgngsispwpwtlrvpglpF--YAKSedqakaklaefqqqygRAIDVGFMQV- 104
Cdd:cd13401     9 LVERAAKKNGLDPALVYAIIRQESA---------------------FdpDAVS----------------PAGALGLMQLm 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385 105 -----SI-RWNGHRVSSPADLLDPETNVMVGAEVLSEAIQSSPNDLEL-------GVGRYHAWEDEIRA----------- 160
Cdd:cd13401    52 patakDVaKKLGLPYYSPRDLFDPEYNIRLGSAYLAELLDRFDGNPVLalaaynaGPGRVRRWLKRRGDldpdlwietip 131

                         170       180
                  ....*....|....*....|.
gi 2755728385 161 ----RNYGSRVLA---IYRNL 174
Cdd:cd13401   132 fsetRNYVKRVLEnyvVYRAL 152
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 31-172 2.64e-05

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 42.11  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  31 KAAKAYNLDPLLVYSVALAESAsgrgngsispwpwtlrvpglpFYAKSEDQAKAklaefqqqygraidVGFMQVS---IR 107
Cdd:cd16896    10 KYAKEYGVDPLLVAAVIKVESN---------------------FNPNAVSSKGA--------------IGLMQIMpetAE 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385 108 W----NGHRVSSPADLLDPETNVMVGAEVLSEAIQSSPNDLELGVGRYHA-------WEDEIRA---------------R 161
Cdd:cd16896    55 WiaekLGLEDFSEDDLYDPETNIRLGTWYLSYLLKEFDGNLVLALAAYNAgpgnvdkWLKDGGWsgdgktldqipfpetR 134

                         170
                  ....*....|.
gi 2755728385 162 NYGSRVLAIYR 172
Cdd:cd16896   135 HYVKKVLKNYK 145
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 99-172 8.42e-05

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 39.89  E-value: 8.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755728385  99 VGFMQV---SIRWNGHRvsSPADLLDPETNVMVGAEVLSEAIQSSPNDLELGVGRYHA-------WEDEIR-----ARNY 163
Cdd:cd00254    25 RGLMQLmpgTARDLGRR--GVDDLFDPEENIRAGARYLRELLDRFGGDLELALAAYNAgpgavdrWGGGEVppykeTRNY 102


                  ....*....
gi 2755728385 164 GSRVLAIYR 172
Cdd:cd00254   103 VQRVLAYYQ 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH