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Conserved domains on  [gi|2755765120|ref|WP_354655118|]
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fibronectin type III domain-containing protein [Bacteroides fragilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
142-225 1.00e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755765120 142 AIGIGENSLTIECKIKDSGSSKLQQFGIAYKVKGEVGEPTRKATSkfkdgtNDTFEITIEGLSAETTYEIYAYAINTKDE 221
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVP------GTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                  ....
gi 2755765120 222 GKSS 225
Cdd:pfam00041  82 GPPS 85
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 244-320 3.30e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 3.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755765120 244 ISEVGANWVTLMAVIEDPGKGEMIekGFYL--SEKNSPDKETTYKVeeksDDNIYSYKVSGLVPNTTYSVRAYAKNRVG 320
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPIT--GYEVeyRPKNSGEPWNEITV----PGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
142-225 1.00e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755765120 142 AIGIGENSLTIECKIKDSGSSKLQQFGIAYKVKGEVGEPTRKATSkfkdgtNDTFEITIEGLSAETTYEIYAYAINTKDE 221
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVP------GTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                  ....
gi 2755765120 222 GKSS 225
Cdd:pfam00041  82 GPPS 85
fn3 pfam00041
Fibronectin type III domain;
244-320 3.30e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 3.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755765120 244 ISEVGANWVTLMAVIEDPGKGEMIekGFYL--SEKNSPDKETTYKVeeksDDNIYSYKVSGLVPNTTYSVRAYAKNRVG 320
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPIT--GYEVeyRPKNSGEPWNEITV----PGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 243-321 4.38e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 4.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755765120  243 EISEVGANWVTL--MAVIEDPGKGEMIEkgfYLSEKNSPDKETtykVEEKSDDNIYSYKVSGLVPNTTYSVRAYAKNRVG 320
Cdd:smart00060   8 RVTDVTSTSVTLswEPPPDDGITGYIVG---YRVEYREEGSEW---KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                   .
gi 2755765120  321 S 321
Cdd:smart00060  82 E 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 279-320 6.46e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 6.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2755765120 279 PDKETTYKVEEKSDDNIYSYKVSGLVPNTTYSVRAYAKNRVG 320
Cdd:cd00063    40 EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
142-225 1.00e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755765120 142 AIGIGENSLTIECKIKDSGSSKLQQFGIAYKVKGEVGEPTRKATSkfkdgtNDTFEITIEGLSAETTYEIYAYAINTKDE 221
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVP------GTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                  ....
gi 2755765120 222 GKSS 225
Cdd:pfam00041  82 GPPS 85
fn3 pfam00041
Fibronectin type III domain;
244-320 3.30e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 3.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755765120 244 ISEVGANWVTLMAVIEDPGKGEMIekGFYL--SEKNSPDKETTYKVeeksDDNIYSYKVSGLVPNTTYSVRAYAKNRVG 320
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPIT--GYEVeyRPKNSGEPWNEITV----PGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 243-321 4.38e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 4.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755765120  243 EISEVGANWVTL--MAVIEDPGKGEMIEkgfYLSEKNSPDKETtykVEEKSDDNIYSYKVSGLVPNTTYSVRAYAKNRVG 320
Cdd:smart00060   8 RVTDVTSTSVTLswEPPPDDGITGYIVG---YRVEYREEGSEW---KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                   .
gi 2755765120  321 S 321
Cdd:smart00060  82 E 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 279-320 6.46e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 6.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2755765120 279 PDKETTYKVEEKSDDNIYSYKVSGLVPNTTYSVRAYAKNRVG 320
Cdd:cd00063    40 EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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