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Conserved domains on  [gi|2775719028|ref|WP_367635278|]
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lytic transglycosylase domain-containing protein [Acetobacter oryzifermentans]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 12989917)

lytic transglycosylase domain-containing protein similar to phage exolysin that catalyzes the cleavage of the host peptidoglycans during virus entry

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 48-159 9.68e-36

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


:

Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 120.33  E-value: 9.68e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775719028  48 HVPAGVLLVLLYVEDG-RPGKISTNTNGTVDLGPMQVNSTWVRKVAEHWHSTplrtyNALRDNVCANIEAGSWILGQALA 126
Cdd:cd13400     2 GVPPRLLRAIAKVESGfNPNAINRNKNGSYDIGLMQINSIWLPELARYGITR-----EELLNDPCTNIYVGAWILARNIK 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2775719028 127 EtHGDLWQAVAYYHSHTPRYGEAYLRRFYHIAT 159
Cdd:cd13400    77 R-YGNTWKAVGAYNSGTPKKNDKYARKVYRIYR 108
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 48-159 9.68e-36

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 120.33  E-value: 9.68e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775719028  48 HVPAGVLLVLLYVEDG-RPGKISTNTNGTVDLGPMQVNSTWVRKVAEHWHSTplrtyNALRDNVCANIEAGSWILGQALA 126
Cdd:cd13400     2 GVPPRLLRAIAKVESGfNPNAINRNKNGSYDIGLMQINSIWLPELARYGITR-----EELLNDPCTNIYVGAWILARNIK 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2775719028 127 EtHGDLWQAVAYYHSHTPRYGEAYLRRFYHIAT 159
Cdd:cd13400    77 R-YGNTWKAVGAYNSGTPKKNDKYARKVYRIYR 108
PRK13888 PRK13888
conjugal transfer protein TrbN; Provisional
 34-167 1.00e-19

conjugal transfer protein TrbN; Provisional


Pssm-ID: 237545  Cd Length: 206  Bit Score: 81.80  E-value: 1.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775719028  34 QRVqTCLSAAASNAHVPAGVLLVLLYVEDGRPGKISTNTNGTVDLGPMQVNSTWVRKvaehwhstpLRTYNALRDNV--- 110
Cdd:PRK13888   13 ERV-VCSISAAVKYEVPANIVLAVAEKEGGKPGQWVRNTNGTHDVGPMQFNTAYLGD---------LARYGITANDVaaa 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2775719028 111 -CANIEAGSWILGQALAETHGDLWQAVAYYHSHTPRYGEAYlrrfyhiATDMMLRARK 167
Cdd:PRK13888   83 gCYSFDLAAWRLRMHIRNDKGDLWTKAANYHSRTPQYNAVY-------RADLMRKASK 133
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 42-141 1.75e-05

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 41.91  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775719028  42 AAASNAHVPAGVLLVLLYVEDG-RPGKIStntnGTVDLGPMQVNSTWVRkvaehWHSTPLRTYNALRDNVCANIEAGSWI 120
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGfNPKAVS----KSGAVGLMQIMPSTAK-----RLGLRVNPGVDDLFDPEKNIKAGTKY 73

                          90       100
                  ....*....|....*....|.
gi 2775719028 121 LGQALAETHGDLWQAVAYYHS 141
Cdd:pfam01464  74 LKELYKQYGGDLWLALAAYNA 94
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 48-159 9.68e-36

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 120.33  E-value: 9.68e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775719028  48 HVPAGVLLVLLYVEDG-RPGKISTNTNGTVDLGPMQVNSTWVRKVAEHWHSTplrtyNALRDNVCANIEAGSWILGQALA 126
Cdd:cd13400     2 GVPPRLLRAIAKVESGfNPNAINRNKNGSYDIGLMQINSIWLPELARYGITR-----EELLNDPCTNIYVGAWILARNIK 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2775719028 127 EtHGDLWQAVAYYHSHTPRYGEAYLRRFYHIAT 159
Cdd:cd13400    77 R-YGNTWKAVGAYNSGTPKKNDKYARKVYRIYR 108
PRK13888 PRK13888
conjugal transfer protein TrbN; Provisional
 34-167 1.00e-19

conjugal transfer protein TrbN; Provisional


Pssm-ID: 237545  Cd Length: 206  Bit Score: 81.80  E-value: 1.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775719028  34 QRVqTCLSAAASNAHVPAGVLLVLLYVEDGRPGKISTNTNGTVDLGPMQVNSTWVRKvaehwhstpLRTYNALRDNV--- 110
Cdd:PRK13888   13 ERV-VCSISAAVKYEVPANIVLAVAEKEGGKPGQWVRNTNGTHDVGPMQFNTAYLGD---------LARYGITANDVaaa 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2775719028 111 -CANIEAGSWILGQALAETHGDLWQAVAYYHSHTPRYGEAYlrrfyhiATDMMLRARK 167
Cdd:PRK13888   83 gCYSFDLAAWRLRMHIRNDKGDLWTKAANYHSRTPQYNAVY-------RADLMRKASK 133
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 42-141 1.75e-05

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 41.91  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775719028  42 AAASNAHVPAGVLLVLLYVEDG-RPGKIStntnGTVDLGPMQVNSTWVRkvaehWHSTPLRTYNALRDNVCANIEAGSWI 120
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGfNPKAVS----KSGAVGLMQIMPSTAK-----RLGLRVNPGVDDLFDPEKNIKAGTKY 73

                          90       100
                  ....*....|....*....|.
gi 2775719028 121 LGQALAETHGDLWQAVAYYHS 141
Cdd:pfam01464  74 LKELYKQYGGDLWLALAAYNA 94
PRK15328 PRK15328
type III secretion system invasion protein IagB;
39-156 1.64e-04

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 39.85  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775719028  39 CLSAAASNAHVPAGVLLVLLYVEDG-RPGKISTNTNGTVDLGPMQVNSTwvrkvaehwHSTPLR----TYNALRDNVCAN 113
Cdd:PRK15328   21 CWLQAEKMFNIESELLYAIAQQESAmKPGAIGHNRDGSTDLGLMQINSF---------HMKRLKkmgiSEKQLLQDPCIS 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2775719028 114 IEAGSWILGQaLAETHGDLWQAVAYYHSHTPRYGEAYLRRFYH 156
Cdd:PRK15328   92 VIVGASILSD-MMKIYGYSWEAVGAYNAGTSPKRSDIRKRYAK 133
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 79-140 8.42e-03

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 34.50  E-value: 8.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2775719028  79 GPMQVNSTWVRKVAEHWHSTPLrtynalrdNVCANIEAGSWILGQALAETHGDLWQAVAYYH 140
Cdd:cd00254    26 GLMQLMPGTARDLGRRGVDDLF--------DPEENIRAGARYLRELLDRFGGDLELALAAYN 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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