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Conserved domains on  [gi|2794664504|ref|WP_372497651|]
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multidrug resistance protein [Priestia megaterium]

Protein Classification

efflux MFS transporter permease( domain architecture ID 1000855)

efflux MFS (major facilitator superfamily) transporter permease, similar to Escherichia coli multidrug efflux pump EmrB and Neisseria gonorrhoeae fatty acid resistance protein FarB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
efflux_EmrB super family cl31024
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 1-114 5.52e-15

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00711:

Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 69.72  E-value: 5.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794664504   1 MMPTITAGMNQLPQHLISHGTALSNTMRQVAGSIDTAILVTIMTQQTTEHLSNYTNTLTTNNDFFSRQLSQLGTSGIMS- 79
Cdd:TIGR00711 366 FMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALGNPEq 445

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2794664504  80 -----LYAKAIKTSTIDGINNAFLFATLLGLVALLLSFFL 114
Cdd:TIGR00711 446 qvyalIAQQITLHAFSIAINEIFWMATLLFVSGLILIWFL 485
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 1-114 5.52e-15

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 69.72  E-value: 5.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794664504   1 MMPTITAGMNQLPQHLISHGTALSNTMRQVAGSIDTAILVTIMTQQTTEHLSNYTNTLTTNNDFFSRQLSQLGTSGIMS- 79
Cdd:TIGR00711 366 FMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALGNPEq 445

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2794664504  80 -----LYAKAIKTSTIDGINNAFLFATLLGLVALLLSFFL 114
Cdd:TIGR00711 446 qvyalIAQQITLHAFSIAINEIFWMATLLFVSGLILIWFL 485
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 1-115 9.59e-13

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 62.98  E-value: 9.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794664504   1 MMPTITAGMNQLPQHLISHGTALSNTMRQVAGSIDTAILVTIMTQQTTEHLSNYTNtlttnndffsrqlsqlgtsgimSL 80
Cdd:cd17503   288 FMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSE----------------------LL 345

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2794664504  81 YAKAIKTSTIDGINNAFLFATLLGLVALLLSFFLR 115
Cdd:cd17503   346 AQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 1-114 5.52e-15

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 69.72  E-value: 5.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794664504   1 MMPTITAGMNQLPQHLISHGTALSNTMRQVAGSIDTAILVTIMTQQTTEHLSNYTNTLTTNNDFFSRQLSQLGTSGIMS- 79
Cdd:TIGR00711 366 FMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALGNPEq 445

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2794664504  80 -----LYAKAIKTSTIDGINNAFLFATLLGLVALLLSFFL 114
Cdd:TIGR00711 446 qvyalIAQQITLHAFSIAINEIFWMATLLFVSGLILIWFL 485
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 1-115 9.59e-13

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 62.98  E-value: 9.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794664504   1 MMPTITAGMNQLPQHLISHGTALSNTMRQVAGSIDTAILVTIMTQQTTEHLSNYTNtlttnndffsrqlsqlgtsgimSL 80
Cdd:cd17503   288 FMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSE----------------------LL 345

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2794664504  81 YAKAIKTSTIDGINNAFLFATLLGLVALLLSFFLR 115
Cdd:cd17503   346 AQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 12-51 7.18e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 34.91  E-value: 7.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2794664504  12 LPQHLISHGTALSNTMRQVAGSIDTAILVTIMTQQTTEHL 51
Cdd:cd06179   383 VPPEDIGTASGLLGSARALGGAVGTAIFTSILSNRLSKNL 422
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 1-52 7.78e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 34.84  E-value: 7.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2794664504   1 MMPTITAGMNQLPQHLISHGTALSNTMRQVAGSIDTAILVTIMTQQTTEHLS 52
Cdd:cd17321   278 ATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLG 329
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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