|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
12-901 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 1287.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 12 NANPNARGKDNSGAAIRQRFLKFYETRGHAVLPSSSLVP-EDPTVLLTIAGMLQFKPVFMGQR-----ERAHERATTTQK 85
Cdd:PLN02900 1 MPEDDAPEKEWPGDRIRRTFLSFFESKGHTFLPSSPLVPvDDPTLLFTNAGMNQFKPIFLGTAdpntpLRKLPRATNTQK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 86 CVRT----NDIENVGVTARHHTFFEMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDD------EAFAIW 155
Cdd:PLN02900 81 CIRAggkhNDLDDVGKDTYHHTFFEMLGNWSFGDYFKKEAIGWAWELLTKVYGLPADRLYATYFGGDEkqapddEARAIW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 156 RDVVgvPESRIKRMDEKDNFWAAGPTGPCGPCSELYYDFYPERGLEGADLDDDSRFIEFYNLVFMELNRDADGGVTPLKN 235
Cdd:PLN02900 161 LDYL--PEERVLPFGCKDNFWEMGDTGPCGPCSEIHYDRIGERDAADLVNNDDPRFIEIWNLVFIQFNREADGSLKPLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 236 KNIDTGMGLERMAQILQGVPNNYETDLIMPIINKAAS------MAGIDYNACNDVQKQQLKVIGDHTRAVSYMISDGVFA 309
Cdd:PLN02900 239 KHVDTGMGLERLASILQNKPSNYDTDLFMPIFDAIQEatgarpYAGKVGAEDDDRVDMAYRVVADHIRTLSFAIADGVVP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 310 SNIGRGYIVRRLLRRVVRNGRLLGiKPEEGasaFTPAIAEVAISMSEGCDPQVAKNSARILAELEREELSFQKTLGRGEE 389
Cdd:PLN02900 319 SNEGRGYVLRRLLRRAVRYGRLLL-GAEEG---FFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGIE 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 390 MLAELIETAK-KTKTGLSGKDAFTLYDTYGFPLDITADVATEAGITVDLEGFESAMAEQRSMSQAAHqtvdVTAGNALAR 468
Cdd:PLN02900 395 KFKKALAAAKaNGGPVLSGKDAFLLYDTYGFPVDLTELMAEERGVTVDMEGFEAAMEEARERSRAAH----LKAGGGAIE 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 469 VADE---------LGAKSTFIGYESTSSDVSNVLAIVCGGESVEEAPEGAKVDIVLDVTPFYAESGGQVGDNGVLHTADG 539
Cdd:PLN02900 471 LAAEatswlqkqgVAATDDFLKYDWLSDHEAVVKAILTGGGFVESVSEGDEVGIVLDKTSFYAESGGQIGDTGVLEGSGG 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 540 ATLEVSDVQKAGGgrIIVHTATVTKGSIKKGSQVTANVDENSRRRAKSNHTATHLLQSALKKVLGEDVSQAGSLCGFDRL 619
Cdd:PLN02900 551 AVVEVSDVQKAGG--FVLHIGTVTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKL 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 620 RFDFNSPKAPTEAQLLEVENLVNGWISQSAALTAEEMPIAAAKD-KGATMMFGEKYGDVVRVVDVPGI-SMELCGGTHVS 697
Cdd:PLN02900 629 RFDFSHGKPMTPEELREVESLVNEWIGDALPVEAKEMPLADAKRiNGLRAVFGEKYPDPVRVVSVGGVySMELCGGTHVS 708
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 698 NTAEIGGFKILSEAGIASGIRRIEAVAGAGVVELLQQRDAVVKQLASALRV------------------------PPEEI 753
Cdd:PLN02900 709 NTAEAEAFKLLSEEGIAKGIRRITAVTGGAAVEAINAADSLERELDSALKVegsdlekkvaslksrvdaavipaaKKEEI 788
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 754 TGRVSSLQEDLRATQKLAESLRGELAVAKAGALVSQAREVGEaKVLVARLD-GVDPAALKVAAENLAAQLGDGAAIVLGS 832
Cdd:PLN02900 789 RARVSALQKELRAAQKEAAALRAKLAVAKATELASKALSAGK-SVLVARLDvGVDAAALKEAAEKVIAKLGDPAAVVLSS 867
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 833 ANGAN-VGLVALFDDKVQKdGGLKAGQVLGAAAKKCGGGGGGKPGFAQAGGRDATQLDAALDEALTTVTA 901
Cdd:PLN02900 868 DEEKGkVSLVAAVPPGVVK-KGLKAGKWLGAIAKLCGGGGGGKPGFAQGQGRDAEKLDAALEKARAFAVA 936
|
|
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
23-903 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 1227.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 23 SGAAIRQRFLKFYETRGHAVLPSSSLVP-EDPTVLLTIAGMLQFKPVFMGQRERAHERATTTQKCVRT----NDIENVGV 97
Cdd:COG0013 3 TSAEIRQKFLDFFESKGHTIVPSSSLVPkNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRTggkhNDLENVGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 98 TARHHTFFEMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDDEAFAIWRDVVGVPESRIKRMDEKDNFWA 177
Cdd:COG0013 83 TARHHTFFEMLGNFSFGDYFKEEAIAWAWELLTEVLGLPKERLWVTVYEDDDEAYDIWKKEIGVPEERIIRLGKKDNFWE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 178 AGPTGPCGPCSELYYDFYPE--RGLEGADLDDDSRFIEFYNLVFMELNRDADGGVTPLKNKNIDTGMGLERMAQILQGVP 255
Cdd:COG0013 163 MGDTGPCGPCSEIFYDRGPEygGGPPGSPGEDGDRYIEIWNLVFMQFNRDEDGTLTPLPKKNIDTGMGLERIAAVLQGVH 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 256 NNYETDLIMPIINKAASMAGIDYNAcNDVQKQQLKVIGDHTRAVSYMISDGVFASNIGRGY---------IVrrllrrvv 326
Cdd:COG0013 243 SNYETDLFRPLIEAAAELTGVKYGA-DEEDDVSLRVIADHIRAVAFLIADGVLPSNEGRGYvlrrilrraVR-------- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 327 rNGRLLGIKpeegaSAFTPAIAEVAISMSEGCDPQVAKNSARILAELEREELSFQKTLGRGEEMLAELIETAKKTKTG-L 405
Cdd:COG0013 314 -HGRLLGIK-----EPFLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLKAAGGKvL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 406 SGKDAFTLYDTYGFPLDITADVATEAGITVDLEGFESAMAEQRSMSQAAHQTVDVTAGNALARVADELGAKSTFIGYEST 485
Cdd:COG0013 388 SGEDAFKLYDTYGFPLDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAKFSGDAAVDGVWRELLEEGGPTEFVGYDTL 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 486 SSDvSNVLAIVCGGESVEEAPEGAKVDIVLDVTPFYAESGGQVGDNGVLhTADGATLEVSDVQKAGGGrIIVHTATVTKG 565
Cdd:COG0013 468 EAE-AKVLALVKDGELVDSAKAGEEVEVVLDRTPFYAESGGQVGDTGTI-EGDGGVFEVTDTQKPPGG-LIVHIGKVEEG 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 566 SIKKGSQVTANVDENSRRRAKSNHTATHLLQSALKKVLGEDVSQAGSLCGFDRLRFDFNSPKAPTEAQLLEVENLVNGWI 645
Cdd:COG0013 545 ELKVGDTVTAQVDAERRRAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSHFEALTPEELAEIEDLVNEKI 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 646 SQSAALTAEEMPIAAAKDKGATMMFGEKYGDVVRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRIEAVAG 725
Cdd:COG0013 625 RENLPVETREMPLDEAKALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTG 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 726 AGVVELLQQRDAVVKQLASALRVPPEEITGRVSSLQEDLRATQKLAESLRGELAVAKAGALVSQAREVGEAKVLVARLDG 805
Cdd:COG0013 705 EAALEYLREQEALLKELAELLKAPPEELPERVEALLEELKELEKELEQLKAKLASAAADDLLAQAEEIGGVKVLAARVEG 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 806 VDPAALKVAAENLAAQLGDGaAIVLGSANGANVGLVALF-DDKVQKdgGLKAGQVLgaaakkcgggGGGKPG-------- 876
Cdd:COG0013 785 VDAKDLRDLADDLKDKLGSG-VVVLASVADGKVSLVAGVtKDLVKK--GLKAGDLV----------KEVAKIvggggggr 851
|
890 900
....*....|....*....|....*....
gi 145348968 877 --FAQAGGRDATQLDAALDEALTTVTAAL 903
Cdd:COG0013 852 pdMAQAGGKDPSKLDEALAAVKEWLAEKL 880
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
27-882 |
0e+00 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 924.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 27 IRQRFLKFYETRGHAVLPSSSLVP-EDPTVLLTIAGMLQFKPVFMGQRERAHERATTTQKCVRTNDIENVGVTARHHTFF 105
Cdd:TIGR00344 2 IRQTFLDFFKEKGHQVIPSAPLVPrNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRLNDLENVGRTARHHTLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 106 EMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDDEAFAIWRDvVGVPESRIKRMDEKDNFWAAGPtGPCG 185
Cdd:TIGR00344 82 EMLGNFSFGDYFKEEAIAFAWELLTEVLGLDKERLYVTVYEDDEEAYKIWEK-IGIPADRIIKCDAKDNFWDMGD-GPCG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 186 PCSELYYDFYPerGLEGADLDDDSRFIEFYNLVFMELNRDADGGVTPLKNKNIDTGMGLERMAQILQGVPNNYETDLIMP 265
Cdd:TIGR00344 160 PCTEIYYDFVG--GKPGEPLEENDRYLEVWNLVFMQFNRDPDGNYTPLPKKNIDTGMGLERFVAVLQGVPTNYDTDIFLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 266 IINKAASMAGIDYN----ACNDVQK----QQLKVIGDHTRAVSYMISDGVFASNIGRGYIVRRLLRRVVRNGRLLGIKpe 337
Cdd:TIGR00344 238 LIEKIEEITGVKYDsnnaGIMDEKRvedlRSLRVIADHTRAIAFMLADGVVPSNEGRGYVLRRLIRRALRHGKKLGLK-- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 338 egaSAFTPAIAEVAISMSEGCDPQVAKNSARILAELEREELSFQKTLGRGEEMLAELIETAKKTKtgLSGKDAFTLYDTY 417
Cdd:TIGR00344 316 ---EAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLFEKLLKKTGKKE--LDGEDAFKLYDTY 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 418 GFPLDITADVATEAGITVDLEGFESAMAEQRSMSQAAHQT-VDVtagNALARVADelgaKSTFIGYESTSSDvSNVLAIV 496
Cdd:TIGR00344 391 GFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKQNSQFqEQE---IALVNVYP----ATEFLGYDDLEFE-AKVIGLF 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 497 CGGESVEEAPEGAKVDIVLDVTPFYAESGGQVGDNGVLhTADGATLEVSDVQKAGGgrIIVHTATVTKGSIKKGSQVTAN 576
Cdd:TIGR00344 463 DDGYLVEQALAGQSVYVILDQTPFYAESGGQIGDTGYL-IANDGKFRVVDVQKPNG--VVFHFGEVEGGSLKVGDKVIAV 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 577 VDENSRRRAKSNHTATHLLQSALKKVLGEDVSQAGSLCGFDRLRFDFNSPKAPTEAQLLEVENLVNGWISQSAALTAEEM 656
Cdd:TIGR00344 540 IDEKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQILANIPIKVIFM 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 657 PIAAAKDKGATMMFGEKY--GDVVRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRIEAVAGAGVVELLQQ 734
Cdd:TIGR00344 620 DLDEAKRKGAFALFGEKYvpGEKVRVVSVGDFSVELCGGTHVRNTGEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYLNE 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 735 RDAVVKQLASALRVPPEEITGRVSSLQEDLRATQKLAESLRGELAVAKAGALVSQAREVGEAKVLVARLDGVDPAALKVA 814
Cdd:TIGR00344 700 QEDKLKELADILKVTPNELPKKVERFFEEWKALQKELESLKLKIADQKIDELKDKAETINGVKVLVEVVDAKDMKSLKTM 779
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145348968 815 AENLAAQLGDgAAIVLGSANGANVGLVALFDDKVQKDgGLKAGQVLGAAAKKCGGGGGGKPGFAQAGG 882
Cdd:TIGR00344 780 ADRLKSKLGS-AIYVLASFAEGKVKLVCGVSNDVLTK-KIKAGELINQIAQVLGGKGGGRPDFAQGGG 845
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
27-580 |
0e+00 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 668.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 27 IRQRFLKFYETRGHAVLPSSSLVPE-DPTVLLTIAGMLQFKPVFMGQRERA-HERATTTQKCVRTNDIENVGVTARHHTF 104
Cdd:pfam01411 2 IRQTFLDFFEKKGHTRVPSSPVVPRnDPTLLFTNAGMNQFKPIFLGGVAKPpYNRATNSQKCIRAGDLENVGRTGRHHTF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 105 FEMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDDEAFAIWRDVVGVPESRIKRMDEKDNFWAAGPTGPC 184
Cdd:pfam01411 82 FEMLGNFSFGDYFKEEAIEYAWELLTKELGLPPERLYVTVFEWDDEAGPIWEKIVGGPEERILRFGDKDNFWEMGDTGPC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 185 GPCSELYYDFYPERGLEGADLD---DDSRFIEFYNLVFMELNRDADGGVTPLKNKNIDTGMGLERMAQILQGVPNNYETD 261
Cdd:pfam01411 162 GPCSEIDYDRGEEIGGWDSGGTptaDDDRFLEIWNLVFMQFNRENDGTLKPLPKKSIDTGMGLERLVAVLQDVRSNYDTD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 262 LIMPIINKAASMAGIDYnACNDVQKQQLKVIGDHTRAVSYMISDGVFASNIGRGYIVRRLLRRVVRNGRLLGIKPeegas 341
Cdd:pfam01411 242 VFIPVIELIEEISGARY-YTVDETDEAYRVIADHTRALTFALADGVVPSNEGRGYVLRRILRRAVRHAKKLGLKE----- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 342 AFTPAIAEVAISMSEGCDPQVAKNSARILAELEREELSFQKTLGRGEEMLAELIETAKKTKTGLSGKDAFTLYDTYGFPL 421
Cdd:pfam01411 316 PFLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLKKGKKTLPGEDAFKLYDTYGFPV 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 422 DITADVATEAGITVDLEGFESAMAEQRSMSQAAHQTVDVTAGNALARvadELGAKSTFIGYESTSSDvSNVLAIVCGGES 501
Cdd:pfam01411 396 DLTKEIAEERGLKVDMPGFEYAMVEQRERSKQAVKEKGEKLDVSALK---ELPATTEFLGYDDLESE-AKILALPKDGEF 471
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145348968 502 VEEAPEGAKVDIVLDVTPFYAESGGQVGDNGVLhTADGATLEVSDVQKAGGgrIIVHTATVTKGSIKKGSQVTANVDEN 580
Cdd:pfam01411 472 VAEVLAGQEGGVILDRTPFYAESGGQIGDTGYI-IGDGGEFRVTDVQKYGG--VVVHKGKLESGKLKVGDKVIAVIDED 547
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
27-254 |
5.84e-129 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 387.10 E-value: 5.84e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 27 IRQRFLKFYETRGHAVLPSSSLVP-EDPTVLLTIAGMLQFKPVFMGQRERAHERATTTQKCVRTNDIENVGVTARHHTFF 105
Cdd:cd00673 4 IRETFLSFFEKKGHTRVPSSPVVPrDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDNVGKTGRHHTFF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 106 EMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDDEAFAIWRDVVGVPESRIKRMDEKDNFWAAGPTGPCG 185
Cdd:cd00673 84 EMLGNFSFGDYFKEEAIAFAWELLTEVLGLPKDRLYVSVFEGDDEEEAIWWWKIGLPGIRIERIGFKDNFWEMGGNGPCG 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145348968 186 PCSELYYDFYPERGLEGADLDDDSRFIEFYNLVFMELNRDADGGVTPLKNKNIDTGMGLERMAQILQGV 254
Cdd:cd00673 164 PCSEIFYDRGEERDAASLPNEDDDRYLEIWNLVFMQYNRDADGTYRPLPKKIVDTGMGLERLVWVLQGV 232
|
|
| a_tRNA_ed_AlaXM |
NF040865 |
alanyl-tRNA editing protein AlaXM; |
513-721 |
9.16e-28 |
|
alanyl-tRNA editing protein AlaXM;
Pssm-ID: 468802 [Multi-domain] Cd Length: 234 Bit Score: 112.32 E-value: 9.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 513 IVLDVTPFYAESGGQVGDNGVLhTADGATLEVSDVQKAGGGriIVHTATVTKGsIKKGSQVTANVDENSRRRAKSNHTAT 592
Cdd:NF040865 26 VVLDRTAFYPTGGGQPHDTGTL-VRDDKEFRVVDVRKEGGE--IAHVVDRAPG-LKPGDKVKGEIDWDRRYRLMRYHTAS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 593 HLLQSALKKVLGEDVSqaGSLCGFDRLRFDFNSPkAPTEAQLLEVENLVNGWISQSAALTAEEMPIAAAKD-----KGAT 667
Cdd:NF040865 102 HILSAVLYREYGALIT--GGQISPDKARVDFSLE-NFDRELLEEIIEEANEIIAEGIEVKIYWLPREEALKipglvRLAK 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 145348968 668 MMFGEKygDVVRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRIE 721
Cdd:NF040865 179 RLPPEI--EEVRIVEIEGVDIQADGGTHVKNTGEIGEIKILKRENKGKGNKRLY 230
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
678-720 |
1.12e-19 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 82.82 E-value: 1.12e-19
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 145348968 678 VRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRI 720
Cdd:smart00863 1 VRVVSIGDFSVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
12-901 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 1287.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 12 NANPNARGKDNSGAAIRQRFLKFYETRGHAVLPSSSLVP-EDPTVLLTIAGMLQFKPVFMGQR-----ERAHERATTTQK 85
Cdd:PLN02900 1 MPEDDAPEKEWPGDRIRRTFLSFFESKGHTFLPSSPLVPvDDPTLLFTNAGMNQFKPIFLGTAdpntpLRKLPRATNTQK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 86 CVRT----NDIENVGVTARHHTFFEMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDD------EAFAIW 155
Cdd:PLN02900 81 CIRAggkhNDLDDVGKDTYHHTFFEMLGNWSFGDYFKKEAIGWAWELLTKVYGLPADRLYATYFGGDEkqapddEARAIW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 156 RDVVgvPESRIKRMDEKDNFWAAGPTGPCGPCSELYYDFYPERGLEGADLDDDSRFIEFYNLVFMELNRDADGGVTPLKN 235
Cdd:PLN02900 161 LDYL--PEERVLPFGCKDNFWEMGDTGPCGPCSEIHYDRIGERDAADLVNNDDPRFIEIWNLVFIQFNREADGSLKPLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 236 KNIDTGMGLERMAQILQGVPNNYETDLIMPIINKAAS------MAGIDYNACNDVQKQQLKVIGDHTRAVSYMISDGVFA 309
Cdd:PLN02900 239 KHVDTGMGLERLASILQNKPSNYDTDLFMPIFDAIQEatgarpYAGKVGAEDDDRVDMAYRVVADHIRTLSFAIADGVVP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 310 SNIGRGYIVRRLLRRVVRNGRLLGiKPEEGasaFTPAIAEVAISMSEGCDPQVAKNSARILAELEREELSFQKTLGRGEE 389
Cdd:PLN02900 319 SNEGRGYVLRRLLRRAVRYGRLLL-GAEEG---FFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGIE 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 390 MLAELIETAK-KTKTGLSGKDAFTLYDTYGFPLDITADVATEAGITVDLEGFESAMAEQRSMSQAAHqtvdVTAGNALAR 468
Cdd:PLN02900 395 KFKKALAAAKaNGGPVLSGKDAFLLYDTYGFPVDLTELMAEERGVTVDMEGFEAAMEEARERSRAAH----LKAGGGAIE 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 469 VADE---------LGAKSTFIGYESTSSDVSNVLAIVCGGESVEEAPEGAKVDIVLDVTPFYAESGGQVGDNGVLHTADG 539
Cdd:PLN02900 471 LAAEatswlqkqgVAATDDFLKYDWLSDHEAVVKAILTGGGFVESVSEGDEVGIVLDKTSFYAESGGQIGDTGVLEGSGG 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 540 ATLEVSDVQKAGGgrIIVHTATVTKGSIKKGSQVTANVDENSRRRAKSNHTATHLLQSALKKVLGEDVSQAGSLCGFDRL 619
Cdd:PLN02900 551 AVVEVSDVQKAGG--FVLHIGTVTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKL 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 620 RFDFNSPKAPTEAQLLEVENLVNGWISQSAALTAEEMPIAAAKD-KGATMMFGEKYGDVVRVVDVPGI-SMELCGGTHVS 697
Cdd:PLN02900 629 RFDFSHGKPMTPEELREVESLVNEWIGDALPVEAKEMPLADAKRiNGLRAVFGEKYPDPVRVVSVGGVySMELCGGTHVS 708
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 698 NTAEIGGFKILSEAGIASGIRRIEAVAGAGVVELLQQRDAVVKQLASALRV------------------------PPEEI 753
Cdd:PLN02900 709 NTAEAEAFKLLSEEGIAKGIRRITAVTGGAAVEAINAADSLERELDSALKVegsdlekkvaslksrvdaavipaaKKEEI 788
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 754 TGRVSSLQEDLRATQKLAESLRGELAVAKAGALVSQAREVGEaKVLVARLD-GVDPAALKVAAENLAAQLGDGAAIVLGS 832
Cdd:PLN02900 789 RARVSALQKELRAAQKEAAALRAKLAVAKATELASKALSAGK-SVLVARLDvGVDAAALKEAAEKVIAKLGDPAAVVLSS 867
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 833 ANGAN-VGLVALFDDKVQKdGGLKAGQVLGAAAKKCGGGGGGKPGFAQAGGRDATQLDAALDEALTTVTA 901
Cdd:PLN02900 868 DEEKGkVSLVAAVPPGVVK-KGLKAGKWLGAIAKLCGGGGGGKPGFAQGQGRDAEKLDAALEKARAFAVA 936
|
|
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
23-903 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 1227.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 23 SGAAIRQRFLKFYETRGHAVLPSSSLVP-EDPTVLLTIAGMLQFKPVFMGQRERAHERATTTQKCVRT----NDIENVGV 97
Cdd:COG0013 3 TSAEIRQKFLDFFESKGHTIVPSSSLVPkNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRTggkhNDLENVGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 98 TARHHTFFEMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDDEAFAIWRDVVGVPESRIKRMDEKDNFWA 177
Cdd:COG0013 83 TARHHTFFEMLGNFSFGDYFKEEAIAWAWELLTEVLGLPKERLWVTVYEDDDEAYDIWKKEIGVPEERIIRLGKKDNFWE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 178 AGPTGPCGPCSELYYDFYPE--RGLEGADLDDDSRFIEFYNLVFMELNRDADGGVTPLKNKNIDTGMGLERMAQILQGVP 255
Cdd:COG0013 163 MGDTGPCGPCSEIFYDRGPEygGGPPGSPGEDGDRYIEIWNLVFMQFNRDEDGTLTPLPKKNIDTGMGLERIAAVLQGVH 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 256 NNYETDLIMPIINKAASMAGIDYNAcNDVQKQQLKVIGDHTRAVSYMISDGVFASNIGRGY---------IVrrllrrvv 326
Cdd:COG0013 243 SNYETDLFRPLIEAAAELTGVKYGA-DEEDDVSLRVIADHIRAVAFLIADGVLPSNEGRGYvlrrilrraVR-------- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 327 rNGRLLGIKpeegaSAFTPAIAEVAISMSEGCDPQVAKNSARILAELEREELSFQKTLGRGEEMLAELIETAKKTKTG-L 405
Cdd:COG0013 314 -HGRLLGIK-----EPFLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLKAAGGKvL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 406 SGKDAFTLYDTYGFPLDITADVATEAGITVDLEGFESAMAEQRSMSQAAHQTVDVTAGNALARVADELGAKSTFIGYEST 485
Cdd:COG0013 388 SGEDAFKLYDTYGFPLDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAKFSGDAAVDGVWRELLEEGGPTEFVGYDTL 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 486 SSDvSNVLAIVCGGESVEEAPEGAKVDIVLDVTPFYAESGGQVGDNGVLhTADGATLEVSDVQKAGGGrIIVHTATVTKG 565
Cdd:COG0013 468 EAE-AKVLALVKDGELVDSAKAGEEVEVVLDRTPFYAESGGQVGDTGTI-EGDGGVFEVTDTQKPPGG-LIVHIGKVEEG 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 566 SIKKGSQVTANVDENSRRRAKSNHTATHLLQSALKKVLGEDVSQAGSLCGFDRLRFDFNSPKAPTEAQLLEVENLVNGWI 645
Cdd:COG0013 545 ELKVGDTVTAQVDAERRRAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSHFEALTPEELAEIEDLVNEKI 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 646 SQSAALTAEEMPIAAAKDKGATMMFGEKYGDVVRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRIEAVAG 725
Cdd:COG0013 625 RENLPVETREMPLDEAKALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTG 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 726 AGVVELLQQRDAVVKQLASALRVPPEEITGRVSSLQEDLRATQKLAESLRGELAVAKAGALVSQAREVGEAKVLVARLDG 805
Cdd:COG0013 705 EAALEYLREQEALLKELAELLKAPPEELPERVEALLEELKELEKELEQLKAKLASAAADDLLAQAEEIGGVKVLAARVEG 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 806 VDPAALKVAAENLAAQLGDGaAIVLGSANGANVGLVALF-DDKVQKdgGLKAGQVLgaaakkcgggGGGKPG-------- 876
Cdd:COG0013 785 VDAKDLRDLADDLKDKLGSG-VVVLASVADGKVSLVAGVtKDLVKK--GLKAGDLV----------KEVAKIvggggggr 851
|
890 900
....*....|....*....|....*....
gi 145348968 877 --FAQAGGRDATQLDAALDEALTTVTAAL 903
Cdd:COG0013 852 pdMAQAGGKDPSKLDEALAAVKEWLAEKL 880
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
27-882 |
0e+00 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 924.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 27 IRQRFLKFYETRGHAVLPSSSLVP-EDPTVLLTIAGMLQFKPVFMGQRERAHERATTTQKCVRTNDIENVGVTARHHTFF 105
Cdd:TIGR00344 2 IRQTFLDFFKEKGHQVIPSAPLVPrNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRLNDLENVGRTARHHTLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 106 EMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDDEAFAIWRDvVGVPESRIKRMDEKDNFWAAGPtGPCG 185
Cdd:TIGR00344 82 EMLGNFSFGDYFKEEAIAFAWELLTEVLGLDKERLYVTVYEDDEEAYKIWEK-IGIPADRIIKCDAKDNFWDMGD-GPCG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 186 PCSELYYDFYPerGLEGADLDDDSRFIEFYNLVFMELNRDADGGVTPLKNKNIDTGMGLERMAQILQGVPNNYETDLIMP 265
Cdd:TIGR00344 160 PCTEIYYDFVG--GKPGEPLEENDRYLEVWNLVFMQFNRDPDGNYTPLPKKNIDTGMGLERFVAVLQGVPTNYDTDIFLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 266 IINKAASMAGIDYN----ACNDVQK----QQLKVIGDHTRAVSYMISDGVFASNIGRGYIVRRLLRRVVRNGRLLGIKpe 337
Cdd:TIGR00344 238 LIEKIEEITGVKYDsnnaGIMDEKRvedlRSLRVIADHTRAIAFMLADGVVPSNEGRGYVLRRLIRRALRHGKKLGLK-- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 338 egaSAFTPAIAEVAISMSEGCDPQVAKNSARILAELEREELSFQKTLGRGEEMLAELIETAKKTKtgLSGKDAFTLYDTY 417
Cdd:TIGR00344 316 ---EAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLFEKLLKKTGKKE--LDGEDAFKLYDTY 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 418 GFPLDITADVATEAGITVDLEGFESAMAEQRSMSQAAHQT-VDVtagNALARVADelgaKSTFIGYESTSSDvSNVLAIV 496
Cdd:TIGR00344 391 GFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKQNSQFqEQE---IALVNVYP----ATEFLGYDDLEFE-AKVIGLF 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 497 CGGESVEEAPEGAKVDIVLDVTPFYAESGGQVGDNGVLhTADGATLEVSDVQKAGGgrIIVHTATVTKGSIKKGSQVTAN 576
Cdd:TIGR00344 463 DDGYLVEQALAGQSVYVILDQTPFYAESGGQIGDTGYL-IANDGKFRVVDVQKPNG--VVFHFGEVEGGSLKVGDKVIAV 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 577 VDENSRRRAKSNHTATHLLQSALKKVLGEDVSQAGSLCGFDRLRFDFNSPKAPTEAQLLEVENLVNGWISQSAALTAEEM 656
Cdd:TIGR00344 540 IDEKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQILANIPIKVIFM 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 657 PIAAAKDKGATMMFGEKY--GDVVRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRIEAVAGAGVVELLQQ 734
Cdd:TIGR00344 620 DLDEAKRKGAFALFGEKYvpGEKVRVVSVGDFSVELCGGTHVRNTGEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYLNE 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 735 RDAVVKQLASALRVPPEEITGRVSSLQEDLRATQKLAESLRGELAVAKAGALVSQAREVGEAKVLVARLDGVDPAALKVA 814
Cdd:TIGR00344 700 QEDKLKELADILKVTPNELPKKVERFFEEWKALQKELESLKLKIADQKIDELKDKAETINGVKVLVEVVDAKDMKSLKTM 779
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145348968 815 AENLAAQLGDgAAIVLGSANGANVGLVALFDDKVQKDgGLKAGQVLGAAAKKCGGGGGGKPGFAQAGG 882
Cdd:TIGR00344 780 ADRLKSKLGS-AIYVLASFAEGKVKLVCGVSNDVLTK-KIKAGELINQIAQVLGGKGGGRPDFAQGGG 845
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
27-580 |
0e+00 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 668.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 27 IRQRFLKFYETRGHAVLPSSSLVPE-DPTVLLTIAGMLQFKPVFMGQRERA-HERATTTQKCVRTNDIENVGVTARHHTF 104
Cdd:pfam01411 2 IRQTFLDFFEKKGHTRVPSSPVVPRnDPTLLFTNAGMNQFKPIFLGGVAKPpYNRATNSQKCIRAGDLENVGRTGRHHTF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 105 FEMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDDEAFAIWRDVVGVPESRIKRMDEKDNFWAAGPTGPC 184
Cdd:pfam01411 82 FEMLGNFSFGDYFKEEAIEYAWELLTKELGLPPERLYVTVFEWDDEAGPIWEKIVGGPEERILRFGDKDNFWEMGDTGPC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 185 GPCSELYYDFYPERGLEGADLD---DDSRFIEFYNLVFMELNRDADGGVTPLKNKNIDTGMGLERMAQILQGVPNNYETD 261
Cdd:pfam01411 162 GPCSEIDYDRGEEIGGWDSGGTptaDDDRFLEIWNLVFMQFNRENDGTLKPLPKKSIDTGMGLERLVAVLQDVRSNYDTD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 262 LIMPIINKAASMAGIDYnACNDVQKQQLKVIGDHTRAVSYMISDGVFASNIGRGYIVRRLLRRVVRNGRLLGIKPeegas 341
Cdd:pfam01411 242 VFIPVIELIEEISGARY-YTVDETDEAYRVIADHTRALTFALADGVVPSNEGRGYVLRRILRRAVRHAKKLGLKE----- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 342 AFTPAIAEVAISMSEGCDPQVAKNSARILAELEREELSFQKTLGRGEEMLAELIETAKKTKTGLSGKDAFTLYDTYGFPL 421
Cdd:pfam01411 316 PFLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLKKGKKTLPGEDAFKLYDTYGFPV 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 422 DITADVATEAGITVDLEGFESAMAEQRSMSQAAHQTVDVTAGNALARvadELGAKSTFIGYESTSSDvSNVLAIVCGGES 501
Cdd:pfam01411 396 DLTKEIAEERGLKVDMPGFEYAMVEQRERSKQAVKEKGEKLDVSALK---ELPATTEFLGYDDLESE-AKILALPKDGEF 471
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145348968 502 VEEAPEGAKVDIVLDVTPFYAESGGQVGDNGVLhTADGATLEVSDVQKAGGgrIIVHTATVTKGSIKKGSQVTANVDEN 580
Cdd:pfam01411 472 VAEVLAGQEGGVILDRTPFYAESGGQIGDTGYI-IGDGGEFRVTDVQKYGG--VVVHKGKLESGKLKVGDKVIAVIDED 547
|
|
| PRK01584 |
PRK01584 |
alanyl-tRNA synthetase; Provisional |
27-723 |
1.20e-147 |
|
alanyl-tRNA synthetase; Provisional
Pssm-ID: 234962 [Multi-domain] Cd Length: 594 Bit Score: 449.22 E-value: 1.20e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 27 IRQRFLKFYETRGHAVLPSSSLVPE-DPTVLLTIAGMLQFKPVFMGQRERAHERATTTQKCVRTNDIENVGvTARHHTFF 105
Cdd:PRK01584 6 LRKKYIDFFKSKGHVEIAGKSLIPEnDPTVLFTTAGMHPLVPYLLGEPHPSGTRLVDVQKCLRTGDIDEVG-DLSHLTFF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 106 EMLGNFSFGDYFKKDACQWAWELATGEFGLN--PERVWVSVFREDD------EAFAIWRDVvGVPESRIKRMDEKDNFWA 177
Cdd:PRK01584 85 EMLGNWSLGAYFKEESIKYSFEFLTSPDYLNipKDKLYVTVFEGDEeiprdeETASVWESL-GIPKDRIFYLSREHNWWG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 178 -AGPTGPCGPCSELYYDfypeRGLEGADLDDD-----SRFIEFYNLVFMELNRDADGGVTPLKNKNIDTGMGLERMAQIL 251
Cdd:PRK01584 164 pVGETGPCGPDTEIFVD----TGKPKCSVNCRptcscGKYFEIWNNVFMQYNKDEDGNYEELKRKCVDTGMGIERTIAFL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 252 QGVPNNYETDLIMPIINKAASMAGIDYNaCNDVQKQQLKVIGDHTRAVSYMISD--GVFASNIGRGYIVRRLLRRVVRNG 329
Cdd:PRK01584 240 QGKSSVYDTEAFTPIIKRIEKISGKIYG-QNEEDDRSIRIIADHIRAACFILGDpfVVLPSNVGQGYVLRRLIRRSIRHA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 330 RLLGIKpeegaSAFTPAIAEVAISMSEGCDPQVAKNSARILAELEREELSFQKTLGRGEEMLAELIETAKKTKTgLSGKD 409
Cdd:PRK01584 319 KKLGIE-----SHFLADLVDSVEEIYGSFYPELTEKKDFIKEELNKEEEKFFKTLRKGEQEFIKLIPNLGSSKI-IPGDI 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 410 AFTLYDTYGFPLDITADVATEAGITVDLEGFESAMAEQRSMSQAahqtvdvtagnalarvadelGAKSTFigyestssdv 489
Cdd:PRK01584 393 AFKLYDTYGFPYEITEELASEYGFTVDREGFDEHFKKHQKVSKK--------------------GADKVF---------- 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 490 snvlaivcggesveeapegakvdivldvtpfyaeSGGqvgdngvlhTADgatlevsdvqkagggriivHTATVTKgsikk 569
Cdd:PRK01584 443 ----------------------------------KGG---------LAD-------------------HSYETTK----- 455
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 570 gsqvtanvdensrrraksNHTATHLLQSALKKVLGEDVSQAGSLCGFDRLRFDFNSPKAPTEAQLLEVENLVNGWISQSA 649
Cdd:PRK01584 456 ------------------LHTATHLLHKALRLVLGDHVRQKGSNITAERLRFDFSHPEKMTDDEIKKVEDIVNLQIKNDL 517
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145348968 650 ALTAEEMPIAAAKDKGATMMFGEKYGDVVRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRIEAV 723
Cdd:PRK01584 518 SVKKEVMSLEEAREKGAMALFGEKYEDIVKVYEIDGFSKEVCGGPHVENTGELGTFKIQKEQSSSSGVRRIRAI 591
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
27-254 |
5.84e-129 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 387.10 E-value: 5.84e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 27 IRQRFLKFYETRGHAVLPSSSLVP-EDPTVLLTIAGMLQFKPVFMGQRERAHERATTTQKCVRTNDIENVGVTARHHTFF 105
Cdd:cd00673 4 IRETFLSFFEKKGHTRVPSSPVVPrDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDNVGKTGRHHTFF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 106 EMLGNFSFGDYFKKDACQWAWELATGEFGLNPERVWVSVFREDDEAFAIWRDVVGVPESRIKRMDEKDNFWAAGPTGPCG 185
Cdd:cd00673 84 EMLGNFSFGDYFKEEAIAFAWELLTEVLGLPKDRLYVSVFEGDDEEEAIWWWKIGLPGIRIERIGFKDNFWEMGGNGPCG 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145348968 186 PCSELYYDFYPERGLEGADLDDDSRFIEFYNLVFMELNRDADGGVTPLKNKNIDTGMGLERMAQILQGV 254
Cdd:cd00673 164 PCSEIFYDRGEERDAASLPNEDDDRYLEIWNLVFMQYNRDADGTYRPLPKKIVDTGMGLERLVWVLQGV 232
|
|
| AlaX |
COG2872 |
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis] ... |
512-721 |
2.67e-33 |
|
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442119 [Multi-domain] Cd Length: 238 Bit Score: 128.39 E-value: 2.67e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 512 DIVLDVTPFYAESGGQVGDNGVLhTADGATLEVSDVQKAGGGriIVHTATvTKGSIKKGSQVTANVDENSRRRAKSNHTA 591
Cdd:COG2872 27 GVVLDRTAFYPTGGGQPGDTGTL-VWDGKEIRVVDVRKEDGE--IVHVLE-GAPLPEVGDEVTGEIDWERRYRHMRLHTA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 592 THLLQSALKKVLGEDVSqAGSLcGFDRLRFDFNSPkAPTEAQLLEVENLVNGWISQSAALTAEEMP---IAAAKDKGATM 668
Cdd:COG2872 103 LHLLSAVVYREYGAPVT-GGQI-GEDRARIDFDLP-EFDEEDLEEIEAEANELIAADLPVRIYWITreeLEAIPGLVRTM 179
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 145348968 669 MFGE-KYGDVVRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRIE 721
Cdd:COG2872 180 SVLPpPGVGRVRIVEIGGVDLQPCGGTHVANTGEIGRIKITKIEKKGKGNRRVY 233
|
|
| a_tRNA_ed_AlaXM |
NF040865 |
alanyl-tRNA editing protein AlaXM; |
513-721 |
9.16e-28 |
|
alanyl-tRNA editing protein AlaXM;
Pssm-ID: 468802 [Multi-domain] Cd Length: 234 Bit Score: 112.32 E-value: 9.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 513 IVLDVTPFYAESGGQVGDNGVLhTADGATLEVSDVQKAGGGriIVHTATVTKGsIKKGSQVTANVDENSRRRAKSNHTAT 592
Cdd:NF040865 26 VVLDRTAFYPTGGGQPHDTGTL-VRDDKEFRVVDVRKEGGE--IAHVVDRAPG-LKPGDKVKGEIDWDRRYRLMRYHTAS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 593 HLLQSALKKVLGEDVSqaGSLCGFDRLRFDFNSPkAPTEAQLLEVENLVNGWISQSAALTAEEMPIAAAKD-----KGAT 667
Cdd:NF040865 102 HILSAVLYREYGALIT--GGQISPDKARVDFSLE-NFDRELLEEIIEEANEIIAEGIEVKIYWLPREEALKipglvRLAK 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 145348968 668 MMFGEKygDVVRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRIE 721
Cdd:NF040865 179 RLPPEI--EEVRIVEIEGVDIQADGGTHVKNTGEIGEIKILKRENKGKGNKRLY 230
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
678-720 |
1.12e-19 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 82.82 E-value: 1.12e-19
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 145348968 678 VRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRI 720
Cdd:smart00863 1 VRVVSIGDFSVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| tRNA_SAD |
pfam07973 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of ... |
678-720 |
1.41e-17 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 429764 [Multi-domain] Cd Length: 43 Bit Score: 76.71 E-value: 1.41e-17
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 145348968 678 VRVVDVPGISMELCGGTHVSNTAEIGGFKILSEAGIASGIRRI 720
Cdd:pfam07973 1 VRVVSIGDFDVDLCGGTHVPNTGEIGAFKILKGESKNKGLRRI 43
|
|
| PLN02961 |
PLN02961 |
alanine-tRNA ligase |
509-707 |
2.41e-15 |
|
alanine-tRNA ligase
Pssm-ID: 178546 [Multi-domain] Cd Length: 223 Bit Score: 76.27 E-value: 2.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 509 AKVDIVLDVTPFYAESGGQVGDNGVLHTADG-ATLEVSDVQKAGGgriIVHTATVTKGS-------IKKGSQVTANVDEN 580
Cdd:PLN02961 1 GRIALVLDRTIFHPQGGGQPSDTGRIVISGGdTKFSVQDVRRKDG---VVYHYGVFEGSnpesaspFEAGDEVTVTVDES 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 581 SRRRAKSNHTATHLLQSALKKV--------------LGEDVSQAGSLCGFDRlrfdfnspkaptEAQLLEVENLVNGWIS 646
Cdd:PLN02961 78 RRKLHSRLHSAGHLLDVCMARVglgplepgkgyhfpDGPFVEYKGKIPQGEL------------DSKQDELEAEANELIA 145
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145348968 647 QSAALTAEEMPI--AAAKDKGATMMFGEKYGD--VVRVVDVPGISmelCGGTHVSNTAEIGGFKI 707
Cdd:PLN02961 146 EGGKVSAAVLPYdeAAELCGGSLPDYIAKDSTprIVKIGDSPGCP---CGGTHVADVSEITSVKV 207
|
|
| DHHA1 |
pfam02272 |
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ... |
757-899 |
3.65e-10 |
|
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members. This domains is also found in alanyl tRNA synthetase, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.
Pssm-ID: 396724 [Multi-domain] Cd Length: 139 Bit Score: 58.99 E-value: 3.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 757 VSSLQEDLRATQKLAESLRGELAVAKAGALVSQAREVGEAKVLVARL-DGVDPAALKVAAENLAAQLGDGAAIVLGSANG 835
Cdd:pfam02272 1 LESLNEELKELEKELEELKEALALLKAKELLEKAEEINGVKVLVAEVgEGWDAGALGIAADRLKKKLGDPVIVLVAKEDG 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145348968 836 ANVGLVAlfddKVQKDGGLKAGQVLGAAAKKCGGgGGGKPGFAQAGGRDATQLDAALDEALTTV 899
Cdd:pfam02272 81 DKVKVSA----RSSKDKGVDAGELLKEVAAILGG-GGGGHDLAAGAGIDAEKLDEALELLEEAI 139
|
|
| class_II_aaRS-like_core |
cd00768 |
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ... |
57-247 |
1.69e-05 |
|
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.
Pssm-ID: 238391 [Multi-domain] Cd Length: 211 Bit Score: 46.73 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 57 LTIAGMLQFKPV--FMGQRERAHERATTTQKCVRtNDIENVGvtARHHTFFEMLGNFSFGDYFkkdacqwawELATGEFG 134
Cdd:cd00768 53 LYLRPTLEPGLVrlFVSHIRKLPLRLAEIGPAFR-NEGGRRG--LRRVREFTQLEGEVFGEDG---------EEASEFEE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 135 LNpERVWvsvfreddeafAIWRDvVGVPESRIKRMDEKDNFWAagptGPCGPCSELYYDFYPERGLE----GADLDDDSR 210
Cdd:cd00768 121 LI-ELTE-----------ELLRA-LGIKLDIVFVEKTPGEFSP----GGAGPGFEIEVDHPEGRGLEigsgGYRQDEQAR 183
|
170 180 190
....*....|....*....|....*....|....*..
gi 145348968 211 FIEFYNLVfmelnRDADGGVTPLKNknidTGMGLERM 247
Cdd:cd00768 184 AADLYFLD-----EALEYRYPPTIG----FGLGLERL 211
|
|
| ThrS |
COG0441 |
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA ... |
588-712 |
5.47e-03 |
|
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440210 [Multi-domain] Cd Length: 639 Bit Score: 40.40 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145348968 588 NHTATHLLQSALKKV-----LG-----EDvsqagslcGFdrlRFDFNSPKAPTEAQLLEVENLVNGWISQSAALTAEEMP 657
Cdd:COG0441 72 RHSAAHLLAQAVKRLypdakLTigpviEN--------GF---YYDFDLERPFTPEDLEKIEKEMKEIIKEDLPIEREEVS 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145348968 658 IAAAKDkgatmMF---GEKY----------GDVVRV------VDvpgismeLCGGTHVSNTAEIGGFKILSEAG 712
Cdd:COG0441 141 REEAIE-----LFkekGEPYkveliedipeDEEISLyrqgefVD-------LCRGPHVPSTGKIKAFKLLSVAG 202
|
|
| |
