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Conserved domains on  [gi|189202924|ref|XP_001937798|]
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uncharacterized protein PTRG_07466 [Pyrenophora tritici-repentis Pt-1C-BFP]

Protein Classification

Alt_A1 domain-containing protein( domain architecture ID 10191029)

Alt_A1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Alt_A1 cd12798
Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with ...
 17-148 1.82e-37

Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with unknown function exclusively found in fungi. The unique structure of Alt a 1 contains intramolecular disulfide bonds that are conserved among the Alt a 1 homologs. Residues reported to be IgE antibody-binding epitopes are exposed through dimerization via a conserved disulfide bond and hydrophobic and polar interactions. Further mechanistic structure/function studies will give insight into immunologic studies directed toward new forms of immunotherapy for Alternaria species-sensitive allergic patients.


:

Pssm-ID: 213998  Cd Length: 132  Bit Score: 124.84  E-value: 1.82e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189202924  17 PLSLDPNFEETITITAYTLVLQNGG-IHNVVFNLTG-NDATNLDCRSNDSIEDLSKIYQCGKfaNVTNSPYSFGLYAtnE 94
Cdd:cd12798    5 PAPQAATSDETIDISDFSGRKPEDGyIDSVSFNINGtNDTLNLTCSAQADGTFDSKIYSCGE--SFGDSAYSFELVK--G 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 189202924  95 DESGYGLRLYHAFGVGIGFYGEGVLNTTCTRFEPVPiSPTYCSQTlQNPVARIP 148
Cdd:cd12798   81 KEADYGLRLYHSVGPDIGLYGTADIPTYCHAGGNGP-GDFICTQV-ADAYITLV 132
 
Name Accession Description Interval E-value
Alt_A1 cd12798
Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with ...
 17-148 1.82e-37

Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with unknown function exclusively found in fungi. The unique structure of Alt a 1 contains intramolecular disulfide bonds that are conserved among the Alt a 1 homologs. Residues reported to be IgE antibody-binding epitopes are exposed through dimerization via a conserved disulfide bond and hydrophobic and polar interactions. Further mechanistic structure/function studies will give insight into immunologic studies directed toward new forms of immunotherapy for Alternaria species-sensitive allergic patients.


Pssm-ID: 213998  Cd Length: 132  Bit Score: 124.84  E-value: 1.82e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189202924  17 PLSLDPNFEETITITAYTLVLQNGG-IHNVVFNLTG-NDATNLDCRSNDSIEDLSKIYQCGKfaNVTNSPYSFGLYAtnE 94
Cdd:cd12798    5 PAPQAATSDETIDISDFSGRKPEDGyIDSVSFNINGtNDTLNLTCSAQADGTFDSKIYSCGE--SFGDSAYSFELVK--G 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 189202924  95 DESGYGLRLYHAFGVGIGFYGEGVLNTTCTRFEPVPiSPTYCSQTlQNPVARIP 148
Cdd:cd12798   81 KEADYGLRLYHSVGPDIGLYGTADIPTYCHAGGNGP-GDFICTQV-ADAYITLV 132
AltA1 pfam16541
Alternaria alternata allergen 1; AltA1 is a family of fungal allergens. It shows a unique ...
 38-124 1.24e-05

Alternaria alternata allergen 1; AltA1 is a family of fungal allergens. It shows a unique beta-barrel comprising 11 beta-strands. There is structural evidence for the location of IgE antibody-binding epitopes. The crystal structure will allow efforts to promote immunotherapy for patients allergic to Alternaria species.


Pssm-ID: 435411  Cd Length: 107  Bit Score: 42.00  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189202924   38 QNGGIHNVVFNLTGNDATN--LDCR-SNDSIEDL---SKIYQCgkfaNVTNSPYSFGLyatNEDESGYGLRLYHAFGVGI 111
Cdd:pfam16541  11 AHNSWGSVSFNLSNTAAGGytVSCSaSSSQLSDFfygDMVYTC----DGGESTFRFSL---GTNRPTGGLALNQEWACEG 83

                          90
                  ....*....|...
gi 189202924  112 GFYGEGVLNTTCT 124
Cdd:pfam16541  84 GFWGTGSVPTYCH 96
 
Name Accession Description Interval E-value
Alt_A1 cd12798
Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with ...
 17-148 1.82e-37

Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with unknown function exclusively found in fungi. The unique structure of Alt a 1 contains intramolecular disulfide bonds that are conserved among the Alt a 1 homologs. Residues reported to be IgE antibody-binding epitopes are exposed through dimerization via a conserved disulfide bond and hydrophobic and polar interactions. Further mechanistic structure/function studies will give insight into immunologic studies directed toward new forms of immunotherapy for Alternaria species-sensitive allergic patients.


Pssm-ID: 213998  Cd Length: 132  Bit Score: 124.84  E-value: 1.82e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189202924  17 PLSLDPNFEETITITAYTLVLQNGG-IHNVVFNLTG-NDATNLDCRSNDSIEDLSKIYQCGKfaNVTNSPYSFGLYAtnE 94
Cdd:cd12798    5 PAPQAATSDETIDISDFSGRKPEDGyIDSVSFNINGtNDTLNLTCSAQADGTFDSKIYSCGE--SFGDSAYSFELVK--G 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 189202924  95 DESGYGLRLYHAFGVGIGFYGEGVLNTTCTRFEPVPiSPTYCSQTlQNPVARIP 148
Cdd:cd12798   81 KEADYGLRLYHSVGPDIGLYGTADIPTYCHAGGNGP-GDFICTQV-ADAYITLV 132
AltA1 pfam16541
Alternaria alternata allergen 1; AltA1 is a family of fungal allergens. It shows a unique ...
 38-124 1.24e-05

Alternaria alternata allergen 1; AltA1 is a family of fungal allergens. It shows a unique beta-barrel comprising 11 beta-strands. There is structural evidence for the location of IgE antibody-binding epitopes. The crystal structure will allow efforts to promote immunotherapy for patients allergic to Alternaria species.


Pssm-ID: 435411  Cd Length: 107  Bit Score: 42.00  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189202924   38 QNGGIHNVVFNLTGNDATN--LDCR-SNDSIEDL---SKIYQCgkfaNVTNSPYSFGLyatNEDESGYGLRLYHAFGVGI 111
Cdd:pfam16541  11 AHNSWGSVSFNLSNTAAGGytVSCSaSSSQLSDFfygDMVYTC----DGGESTFRFSL---GTNRPTGGLALNQEWACEG 83

                          90
                  ....*....|...
gi 189202924  112 GFYGEGVLNTTCT 124
Cdd:pfam16541  84 GFWGTGSVPTYCH 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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