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Conserved domains on  [gi|195107563|ref|XP_001998378|]
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E3 UFM1-protein ligase 1 homolog [Drosophila mojavensis]

Protein Classification

E3 UFM1-protein ligase 1( domain architecture ID 10560867)

E3 UFM1-protein ligase 1 acts as E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
E3_UFM1_ligase pfam09743
E3 UFM1-protein ligase 1; The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ...
 7-280 7.49e-135

E3 UFM1-protein ligase 1; The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organizms. Ufm1 is known to covalently attach with cellular protein(s) via a specific E1-activating enzyme (Uba5), an E2-conjugating enzyme (Ufc1), and a E3-ligating enzyme.


:

Pssm-ID: 462874  Cd Length: 272  Bit Score: 400.38  E-value: 7.49e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563    7 EIKRLAADFQKAQLTSTLQKLSERNCIEIVTLLLEKQLLDVVFTNDGKEYITPEHLEREIQDELYANGGRANLVEVSKTL 86
Cdd:pfam09743   1 EILELAADFQRAQLSSSSQRLSERNCIEIVNKLIELKLLDLIHTTDGKEYITPEQLEKEIKDELLAHGGRVNLVDLAKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563   87 NVDLSRIEALAERIAADNPQIHLMLGQLIDEDYITHIAQEINEKLSQRGEISISDLTSQFDLPSEFLQhNVMEKHLGKTI 166
Cdd:pfam09743  81 NVDLDHIERQAQEIVKEDPELMLVNGELITKSYLDSIAEEINEKLQECGQITIAELAKQYDLPSDFLL-SLLEKRLGKII 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563  167 KGRQDatnPRVFFTQAYIQRCKAKIRGALAAITKPTNVSVILQQINVQEKIFHSLLDEIMPAGQVTSK--QANAQYVPHI 244
Cdd:pfam09743 160 KGVLD---GGVLYTEAYVARHKAKVRGALRAITRPTPLSALLKRYGLPEKLFYSLLEELIKEGRIPGSliGGRAVYIPTI 236

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 195107563  245 YAKTQAEWVNSFYKQNSFLEYEAINKLGISDAKAYI 280
Cdd:pfam09743 237 YSKTQSEWVDSFYKQNGYIEYDTLQRLGISDPKSYL 272
 
Name Accession Description Interval E-value
E3_UFM1_ligase pfam09743
E3 UFM1-protein ligase 1; The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ...
 7-280 7.49e-135

E3 UFM1-protein ligase 1; The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organizms. Ufm1 is known to covalently attach with cellular protein(s) via a specific E1-activating enzyme (Uba5), an E2-conjugating enzyme (Ufc1), and a E3-ligating enzyme.


Pssm-ID: 462874  Cd Length: 272  Bit Score: 400.38  E-value: 7.49e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563    7 EIKRLAADFQKAQLTSTLQKLSERNCIEIVTLLLEKQLLDVVFTNDGKEYITPEHLEREIQDELYANGGRANLVEVSKTL 86
Cdd:pfam09743   1 EILELAADFQRAQLSSSSQRLSERNCIEIVNKLIELKLLDLIHTTDGKEYITPEQLEKEIKDELLAHGGRVNLVDLAKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563   87 NVDLSRIEALAERIAADNPQIHLMLGQLIDEDYITHIAQEINEKLSQRGEISISDLTSQFDLPSEFLQhNVMEKHLGKTI 166
Cdd:pfam09743  81 NVDLDHIERQAQEIVKEDPELMLVNGELITKSYLDSIAEEINEKLQECGQITIAELAKQYDLPSDFLL-SLLEKRLGKII 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563  167 KGRQDatnPRVFFTQAYIQRCKAKIRGALAAITKPTNVSVILQQINVQEKIFHSLLDEIMPAGQVTSK--QANAQYVPHI 244
Cdd:pfam09743 160 KGVLD---GGVLYTEAYVARHKAKVRGALRAITRPTPLSALLKRYGLPEKLFYSLLEELIKEGRIPGSliGGRAVYIPTI 236

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 195107563  245 YAKTQAEWVNSFYKQNSFLEYEAINKLGISDAKAYI 280
Cdd:pfam09743 237 YSKTQSEWVDSFYKQNGYIEYDTLQRLGISDPKSYL 272
PLN03083 PLN03083
E3 UFM1-protein ligase 1 homolog; Provisional
 6-752 1.04e-72

E3 UFM1-protein ligase 1 homolog; Provisional


Pssm-ID: 215565  Cd Length: 803  Bit Score: 253.21  E-value: 1.04e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563   6 DEIKRLAADFQKAQLTSTLQKLSERNCIEIVTLLLEKQLL--DVVFTNDGKEYITPEHLEREIQDELyANGGRANLVEVS 83
Cdd:PLN03083   3 AELLELQRQFEFAQQAKSSVRLSERNVVELVQKLQELGIIdfDLLHTVSGKEYITQDQLRNEIEAEI-KKLGRVSLVDLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563  84 KTLNVDLSRIEALAERIAADNPQIHLMLGQLIDEDYITHIAQEINEKLSQRGEISISDLTSQFDLPSEFLQhNVMEKHLG 163
Cdd:PLN03083  82 DTIGVDLYHVERQAQQVVSDDPGLMLVQGEIISQSYWDSIAEEINERLQECSQIALAELARQLQVGSELVT-SMLEPRLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 164 KTIKGRQDATNprvFFTQAYIQRCKAKIRGALAAITKPTNVSVI---LQQ----------INVQEKIFHSLLDEIMPAGQ 230
Cdd:PLN03083 161 TIVKARLEGGQ---LYTPAYVARVTAMVRGAARGITVPTNLSSLwnsLQQllremdgaggVTVEGSFFQSIFNGLVKEEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 231 VT-SKQANAQYVPHIYAKTQAEWVNSFYKQNSFLEYEAINKLGISDAKAYIRKQFPNEQFLflkrVALGAH--LIELtVV 307
Cdd:PLN03083 238 VLgSLRAGTHWTPAVFAHAQKESVDAFFSQNSYITYDTLQKLGISQPKQFLQSRYPDGIAL----DAVFVHssMIEM-LD 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 308 SALNECSATKQYLDLATILPSNLSEEDIEEAFDAV-MAQKHCNPSQFVYL-QSIVFSQAYltqlIQPCHDMAHALAKAAI 385
Cdd:PLN03083 313 SAAEDAIEGGSWIDSLSVLPSSFGSQDAGKLLLLCpSVQSALKDSKALILgESCVLSNGF----IKGIYDQIEKEMDAFS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 386 DSGAYQQYIVEKTLAQKGSNSSANFDADDDGKVDKRDERRKKAASGKAGGGAQGRETKTKSTKKHQRGRAAAHNHDSDDD 465
Cdd:PLN03083 389 IQASSAGLIGSSEKSLGSNESSPAASNSDKGSKKKKGKSTSTKGGTAESIPDDEEDAPKKGKKNQKKGRDKSSKVPSDSK 468

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 466 EETTQQSAGSSRKS--VKPLELVKSSdvINRIKSTLEEEGLEH---LAKPIAGLFVNQLNQAALAKAQELYEATPQTNRR 540
Cdd:PLN03083 469 AGGKKESVKSQEDNnnIPPEEWVMKK--ILEWVPDLEEDGTEDpgsILKHLADHLRPMLINSLKERRKALFTENAERRRR 546

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 541 QTHaAIQERVNTLLVDLRLYEKGIKLFNTD--TQAQLIKYLLKSLGNDICNELTLYVA----------AECSLSVKMTNL 608
Cdd:PLN03083 547 LLD-NLQKKIDESFLNMQLYEKALDLFEDDqsTSVVLHRHLLRTTAAEIADTLLHTLDihnklkngteVEDSKTQDTVLL 625

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 609 NVDQRIKLIQECDAQYRNALLEQNKAL-NKSIEDFELATEAVLKTCSMIIKKADKKKDRALIVSHKEKLMQQLSECREPA 687
Cdd:PLN03083 626 SSAERTALAKNLPGSLSSKALALVEALeGKRVDAFMSTLRDLAEESGLRLKKLDKKLERTLLHSYRKDLTSQVSTESDPV 705

                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195107563 688 LLLHLAALILFTTITGCILHASGKFVSTILQHIRPTLNESQNALLLRYHDLVLQMLQQGTTDSPE 752
Cdd:PLN03083 706 ALLPKVVSLLYVQVHNKALQAPGRAISAAISRLKDKLPDSAYKTLTDYHSATVTLLALMSAATGE 770
 
Name Accession Description Interval E-value
E3_UFM1_ligase pfam09743
E3 UFM1-protein ligase 1; The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ...
 7-280 7.49e-135

E3 UFM1-protein ligase 1; The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organizms. Ufm1 is known to covalently attach with cellular protein(s) via a specific E1-activating enzyme (Uba5), an E2-conjugating enzyme (Ufc1), and a E3-ligating enzyme.


Pssm-ID: 462874  Cd Length: 272  Bit Score: 400.38  E-value: 7.49e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563    7 EIKRLAADFQKAQLTSTLQKLSERNCIEIVTLLLEKQLLDVVFTNDGKEYITPEHLEREIQDELYANGGRANLVEVSKTL 86
Cdd:pfam09743   1 EILELAADFQRAQLSSSSQRLSERNCIEIVNKLIELKLLDLIHTTDGKEYITPEQLEKEIKDELLAHGGRVNLVDLAKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563   87 NVDLSRIEALAERIAADNPQIHLMLGQLIDEDYITHIAQEINEKLSQRGEISISDLTSQFDLPSEFLQhNVMEKHLGKTI 166
Cdd:pfam09743  81 NVDLDHIERQAQEIVKEDPELMLVNGELITKSYLDSIAEEINEKLQECGQITIAELAKQYDLPSDFLL-SLLEKRLGKII 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563  167 KGRQDatnPRVFFTQAYIQRCKAKIRGALAAITKPTNVSVILQQINVQEKIFHSLLDEIMPAGQVTSK--QANAQYVPHI 244
Cdd:pfam09743 160 KGVLD---GGVLYTEAYVARHKAKVRGALRAITRPTPLSALLKRYGLPEKLFYSLLEELIKEGRIPGSliGGRAVYIPTI 236

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 195107563  245 YAKTQAEWVNSFYKQNSFLEYEAINKLGISDAKAYI 280
Cdd:pfam09743 237 YSKTQSEWVDSFYKQNGYIEYDTLQRLGISDPKSYL 272
PLN03083 PLN03083
E3 UFM1-protein ligase 1 homolog; Provisional
 6-752 1.04e-72

E3 UFM1-protein ligase 1 homolog; Provisional


Pssm-ID: 215565  Cd Length: 803  Bit Score: 253.21  E-value: 1.04e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563   6 DEIKRLAADFQKAQLTSTLQKLSERNCIEIVTLLLEKQLL--DVVFTNDGKEYITPEHLEREIQDELyANGGRANLVEVS 83
Cdd:PLN03083   3 AELLELQRQFEFAQQAKSSVRLSERNVVELVQKLQELGIIdfDLLHTVSGKEYITQDQLRNEIEAEI-KKLGRVSLVDLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563  84 KTLNVDLSRIEALAERIAADNPQIHLMLGQLIDEDYITHIAQEINEKLSQRGEISISDLTSQFDLPSEFLQhNVMEKHLG 163
Cdd:PLN03083  82 DTIGVDLYHVERQAQQVVSDDPGLMLVQGEIISQSYWDSIAEEINERLQECSQIALAELARQLQVGSELVT-SMLEPRLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 164 KTIKGRQDATNprvFFTQAYIQRCKAKIRGALAAITKPTNVSVI---LQQ----------INVQEKIFHSLLDEIMPAGQ 230
Cdd:PLN03083 161 TIVKARLEGGQ---LYTPAYVARVTAMVRGAARGITVPTNLSSLwnsLQQllremdgaggVTVEGSFFQSIFNGLVKEEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 231 VT-SKQANAQYVPHIYAKTQAEWVNSFYKQNSFLEYEAINKLGISDAKAYIRKQFPNEQFLflkrVALGAH--LIELtVV 307
Cdd:PLN03083 238 VLgSLRAGTHWTPAVFAHAQKESVDAFFSQNSYITYDTLQKLGISQPKQFLQSRYPDGIAL----DAVFVHssMIEM-LD 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 308 SALNECSATKQYLDLATILPSNLSEEDIEEAFDAV-MAQKHCNPSQFVYL-QSIVFSQAYltqlIQPCHDMAHALAKAAI 385
Cdd:PLN03083 313 SAAEDAIEGGSWIDSLSVLPSSFGSQDAGKLLLLCpSVQSALKDSKALILgESCVLSNGF----IKGIYDQIEKEMDAFS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 386 DSGAYQQYIVEKTLAQKGSNSSANFDADDDGKVDKRDERRKKAASGKAGGGAQGRETKTKSTKKHQRGRAAAHNHDSDDD 465
Cdd:PLN03083 389 IQASSAGLIGSSEKSLGSNESSPAASNSDKGSKKKKGKSTSTKGGTAESIPDDEEDAPKKGKKNQKKGRDKSSKVPSDSK 468

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 466 EETTQQSAGSSRKS--VKPLELVKSSdvINRIKSTLEEEGLEH---LAKPIAGLFVNQLNQAALAKAQELYEATPQTNRR 540
Cdd:PLN03083 469 AGGKKESVKSQEDNnnIPPEEWVMKK--ILEWVPDLEEDGTEDpgsILKHLADHLRPMLINSLKERRKALFTENAERRRR 546

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 541 QTHaAIQERVNTLLVDLRLYEKGIKLFNTD--TQAQLIKYLLKSLGNDICNELTLYVA----------AECSLSVKMTNL 608
Cdd:PLN03083 547 LLD-NLQKKIDESFLNMQLYEKALDLFEDDqsTSVVLHRHLLRTTAAEIADTLLHTLDihnklkngteVEDSKTQDTVLL 625

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195107563 609 NVDQRIKLIQECDAQYRNALLEQNKAL-NKSIEDFELATEAVLKTCSMIIKKADKKKDRALIVSHKEKLMQQLSECREPA 687
Cdd:PLN03083 626 SSAERTALAKNLPGSLSSKALALVEALeGKRVDAFMSTLRDLAEESGLRLKKLDKKLERTLLHSYRKDLTSQVSTESDPV 705

                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195107563 688 LLLHLAALILFTTITGCILHASGKFVSTILQHIRPTLNESQNALLLRYHDLVLQMLQQGTTDSPE 752
Cdd:PLN03083 706 ALLPKVVSLLYVQVHNKALQAPGRAISAAISRLKDKLPDSAYKTLTDYHSATVTLLALMSAATGE 770
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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