NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|254583259|ref|XP_002499361|]
View 

uncharacterized protein ZYRO0E09988g [Zygosaccharomyces rouxii]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 110-541 2.31e-122

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 364.59  E-value: 2.31e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17323    4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSE--LYGRRPVYLVSLFIFVIFQIGC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMW 269
Cdd:cd17323   82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 270 MSALLLVTLIFFFPetsednilhrrcerikkitgddryytfkareesklnakdiaiialyrpfeimvkepIVQALDIYIA 349
Cdd:cd17323  162 ISGFCLILIFLFLP--------------------------------------------------------IVLLLGLYVG 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFLVGSFVAYAASIIFLHYYADR--KMANGTFTPETFLVLAMCVSWC 427
Cdd:cd17323  186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlkKKNGGKPEPEARLPPAFIGAFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 428 LPCGLFIFGWAA--SVHWMVPIAAELLFVMCDFNLWESIFSYLAVSYPKYVASVFAGNGVLRAGFACAFPLFGKAMYDNL 505
Cdd:cd17323  266 FPIGLFIFGWTIypHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 254583259 506 aidgyPVGWGSSLLGFITIGLALLPFLFYKYGPYLR 541
Cdd:cd17323  346 -----GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 110-541 2.31e-122

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 364.59  E-value: 2.31e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17323    4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSE--LYGRRPVYLVSLFIFVIFQIGC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMW 269
Cdd:cd17323   82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 270 MSALLLVTLIFFFPetsednilhrrcerikkitgddryytfkareesklnakdiaiialyrpfeimvkepIVQALDIYIA 349
Cdd:cd17323  162 ISGFCLILIFLFLP--------------------------------------------------------IVLLLGLYVG 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFLVGSFVAYAASIIFLHYYADR--KMANGTFTPETFLVLAMCVSWC 427
Cdd:cd17323  186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlkKKNGGKPEPEARLPPAFIGAFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 428 LPCGLFIFGWAA--SVHWMVPIAAELLFVMCDFNLWESIFSYLAVSYPKYVASVFAGNGVLRAGFACAFPLFGKAMYDNL 505
Cdd:cd17323  266 FPIGLFIFGWTIypHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 254583259 506 aidgyPVGWGSSLLGFITIGLALLPFLFYKYGPYLR 541
Cdd:cd17323  346 -----GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
2_A_01_02 TIGR00880
Multidrug resistance protein;
147-285 1.14e-34

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 127.38  E-value: 1.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  147 SVYVIGYGIGPIIFSPLSEF--AIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVV 224
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254583259  225 RPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMWMSALLLVTLIFFFPET 285
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
110-440 7.80e-28

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 114.30  E-value: 7.80e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:COG2814   15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD--RFGRRRVLLLGLLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMW 269
Cdd:COG2814   93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 270 MSALLLVTLIFFFPETSEDNilhrrcerikkitgddryytfKAREESKLNAkdiaiialyrpfeiMVKEPIVQALDIYIA 349
Cdd:COG2814  173 LALLALLLLLRLLPESRPAA---------------------RARLRGSLRE--------------LLRRPRLLLLLLLAF 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFLVGSFVAYAASIIFLHYYADRKMANGTFTPETFLVLAMCVS---W 426
Cdd:COG2814  218 LLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAgslW 297

                        330
                 ....*....|....
gi 254583259 427 CLPCGLFIFGWAAS 440
Cdd:COG2814  298 LLLLALFLLGFGFG 311
MFS_1 pfam07690
Major Facilitator Superfamily;
110-482 3.38e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 100.96  E-value: 3.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  110 VSLLTFITYMGSSIYTPG-QEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAG 188
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD--RFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  189 CALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLM 268
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  269 WMSALLLVTLIFFFPEtsednilhrrcerikkitgddryytfkaREESKLNAKDIAIIALYRPFEIMVKEPIVQALdIYI 348
Cdd:pfam07690 159 ILSLLAAVLLLLPRPP----------------------------PESKRPKPAEEARLSLIVAWKALLRDPVLWLL-LAL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  349 ALTYGIFYLFFESFPiVFSGIYHFTLIELGLSY-LGFLVGSFVAyaasiIFLHYYADRkmangtFTPETFLVLAMCVSWC 427
Cdd:pfam07690 210 LLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLgLGGLLGAIGR-----LLLGRLSDR------LGRRRRLLLALLLLIL 277

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254583259  428 LPCGLFIFGWAASVHWMVPIAaeLLFVMCDFNLWESIFSYLAVSYPKYVASVFAG 482
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLAL--LLLGFGFGLVFPALNALVSDLAPKEERGTASG 330
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
124-285 9.86e-16

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 78.80  E-value: 9.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 124 YTPGQEQIQQEFGV--GHVVATLnlSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVIL 201
Cdd:PRK11102  10 YLPALPVIAADFGVsaGSVQMTL--SAYILGFAIGQLFYGPMAD--SFGRKPVILGGTLVFALAAVACALAQTIDQLIYM 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 202 RFLTGVlcspSLATGAASIGDVVRPKY-----------VPILLGLwsgaayaAPCVGPLIGAAMVIAKNWRWIFWLLMWM 270
Cdd:PRK11102  86 RFLHGL----AAAAASVVINALMRDMFpkeefsrmmsfVTLVMTI-------APLLAPIIGGWLLVWFSWHAIFWVLALA 154

                        170
                 ....*....|....*.
gi 254583259 271 sALLLVTLIFFF-PET 285
Cdd:PRK11102 155 -AILAAALVFFFiPET 169
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 110-541 2.31e-122

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 364.59  E-value: 2.31e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17323    4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSE--LYGRRPVYLVSLFIFVIFQIGC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMW 269
Cdd:cd17323   82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 270 MSALLLVTLIFFFPetsednilhrrcerikkitgddryytfkareesklnakdiaiialyrpfeimvkepIVQALDIYIA 349
Cdd:cd17323  162 ISGFCLILIFLFLP--------------------------------------------------------IVLLLGLYVG 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFLVGSFVAYAASIIFLHYYADR--KMANGTFTPETFLVLAMCVSWC 427
Cdd:cd17323  186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlkKKNGGKPEPEARLPPAFIGAFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 428 LPCGLFIFGWAA--SVHWMVPIAAELLFVMCDFNLWESIFSYLAVSYPKYVASVFAGNGVLRAGFACAFPLFGKAMYDNL 505
Cdd:cd17323  266 FPIGLFIFGWTIypHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 254583259 506 aidgyPVGWGSSLLGFITIGLALLPFLFYKYGPYLR 541
Cdd:cd17323  346 -----GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
2_A_01_02 TIGR00880
Multidrug resistance protein;
147-285 1.14e-34

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 127.38  E-value: 1.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  147 SVYVIGYGIGPIIFSPLSEF--AIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVV 224
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254583259  225 RPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMWMSALLLVTLIFFFPET 285
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 110-529 1.03e-28

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 117.68  E-value: 1.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17320    4 LALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSD--RFGRRPVLLAGLLLFILASLLC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMW 269
Cdd:cd17320   82 ALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 270 MSALLLVTLIFFFPETsednilhrrcerikkitgddryytfKAREESKLNAKDIAIIALYrpfeiMVKEPIVQALDIYIA 349
Cdd:cd17320  162 LGLLLLLLVLLFLPET-------------------------LPEEKRKPLLSSLLRAYKR-----VLKNRRFLGYALALG 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFLVGSFVAYAASIIFLHYYADRKMANGtftpeTFLVLAMCVSWCLp 429
Cdd:cd17320  212 LSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRL-----GLLLLLAAALVLL- 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 430 cgLFIFGWAASVHWMVPIaaeLLFVMCDFNLWESIFSYLAVS-YPKYVASVFAGNGVLRAGFACAFPLFGKAMYDNLAId 508
Cdd:cd17320  286 --LAALLGGLSLWPLVAP---LFLIFFGFGLIFPNATSLALEpFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTAL- 359

                        410       420
                 ....*....|....*....|.
gi 254583259 509 gyPVGWGSSLLGFITIGLALL 529
Cdd:cd17320  360 --PMGLLILVLGLLALLLLIL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
110-440 7.80e-28

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 114.30  E-value: 7.80e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:COG2814   15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD--RFGRRRVLLLGLLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMW 269
Cdd:COG2814   93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 270 MSALLLVTLIFFFPETSEDNilhrrcerikkitgddryytfKAREESKLNAkdiaiialyrpfeiMVKEPIVQALDIYIA 349
Cdd:COG2814  173 LALLALLLLLRLLPESRPAA---------------------RARLRGSLRE--------------LLRRPRLLLLLLLAF 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFLVGSFVAYAASIIFLHYYADRKMANGTFTPETFLVLAMCVS---W 426
Cdd:COG2814  218 LLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAgslW 297

                        330
                 ....*....|....
gi 254583259 427 CLPCGLFIFGWAAS 440
Cdd:COG2814  298 LLLLALFLLGFGFG 311
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 99-285 2.56e-23

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 100.27  E-value: 2.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  99 STLKKTIVITEVSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVT 178
Cdd:COG0477    8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGD--RYGRKRVLLIG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 179 LFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAK 258
Cdd:COG0477   86 LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165

                        170       180
                 ....*....|....*....|....*..
gi 254583259 259 NWRWIFWLLMWMSALLLVtLIFFFPET 285
Cdd:COG0477  166 GWRWIFLINAPLGLLALV-LRLRLPES 191
MFS_1 pfam07690
Major Facilitator Superfamily;
110-482 3.38e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 100.96  E-value: 3.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  110 VSLLTFITYMGSSIYTPG-QEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAG 188
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD--RFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  189 CALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLM 268
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  269 WMSALLLVTLIFFFPEtsednilhrrcerikkitgddryytfkaREESKLNAKDIAIIALYRPFEIMVKEPIVQALdIYI 348
Cdd:pfam07690 159 ILSLLAAVLLLLPRPP----------------------------PESKRPKPAEEARLSLIVAWKALLRDPVLWLL-LAL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  349 ALTYGIFYLFFESFPiVFSGIYHFTLIELGLSY-LGFLVGSFVAyaasiIFLHYYADRkmangtFTPETFLVLAMCVSWC 427
Cdd:pfam07690 210 LLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLgLGGLLGAIGR-----LLLGRLSDR------LGRRRRLLLALLLLIL 277

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254583259  428 LPCGLFIFGWAASVHWMVPIAaeLLFVMCDFNLWESIFSYLAVSYPKYVASVFAG 482
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLAL--LLLGFGFGLVFPALNALVSDLAPKEERGTASG 330
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 110-528 1.48e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 93.65  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMV--IAKNWRWIFWLL 267
Cdd:cd06174   79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 268 MWMSALLLVTLIFFFPETSEDNILHrrcerikkitgddryytfKAREESKLNAKDIAIIALYRPFEIMVkepivqaldIY 347
Cdd:cd06174  159 AALALLAAILLLLVVPDPPESARAK------------------NEEASSKSVLKLLKRVLKNPGLWLLL---------LA 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 348 IALTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFLVGSFVAYAASIIFLHYYADRKmangtftpetflVLAMCVSWC 427
Cdd:cd06174  212 IFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRK------------PLLLIGLLL 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 428 LPCGLFIFGWAASVHWMVPIAaeLLFVMCDFNLWESIFSYLAVSYPKYVASVFAG--NGVLRAGFACAFPLFGkaMYDNL 505
Cdd:cd06174  280 MALGLALLLLAPSLLLLLLLL--LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGllNTFGFLGGAIGPLLAG--FLLAA 355

                        410       420
                 ....*....|....*....|...
gi 254583259 506 AIDGYPVGWGSSLLGFITIGLAL 528
Cdd:cd06174  356 TFGLTGAFLVLAVLLLLAAILLL 378
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 111-389 7.30e-19

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 88.59  E-value: 7.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  111 SLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCA 190
Cdd:TIGR00710  11 GCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSD--RYGRRPVLLLGLFIFALSSLGLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  191 LVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMwM 270
Cdd:TIGR00710  89 LSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLS-L 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  271 SALLLVTLIFFF-PETsednilhrrcerikkitgddryytfKAREESKLNAKDIaiialyRPFEIMVKEPIVQALDIYIA 349
Cdd:TIGR00710 168 AGILLSALIFFIlPET-------------------------LPYEARIQISTYF------ETFLLLLKSKMFWGYALIYG 216

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 254583259  350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSY----LGFLVGSF 389
Cdd:TIGR00710 217 ASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFalniIAMIFGGF 260
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 130-391 2.09e-18

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 86.83  E-value: 2.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 130 QIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSefAIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLC 209
Cdd:cd17324   24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLS--DRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 210 SPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMWMSALLLVTLIFFFPETSEDN 289
Cdd:cd17324  102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 290 ILHRRcerikkitgddryytfkareesklnakdiaiiaLYRPFEIMVKEPIVQALDIYIALTYGIFYLFFESFPIVFSGI 369
Cdd:cd17324  182 PGSLG---------------------------------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDV 228

                        250       260
                 ....*....|....*....|..
gi 254583259 370 YHFTLIELGLSYLGFLVGSFVA 391
Cdd:cd17324  229 PGFSSSAIIGLLLLFGVAGVVG 250
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 110-449 9.77e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 81.85  E-value: 9.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEFaiFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17474    4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADR--FGRKKVLLPGLLLFGIGGLLC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMViAKNWRWIFWLLMW 269
Cdd:cd17474   82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 270 MSALLLVTLIFFFPETSEdnilhrrcerikkitgddryytfKAREESKLNAKDIAIIALYRPFEIMVkepivqaldIYIA 349
Cdd:cd17474  161 LIPVAFLAILFLLPEPKE-----------------------KAKSSSATKLRDLKKALRGRGLLTFL---------VSAF 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFLVGSfvayAASIIFLHYYADRKmangtFTPETFLVLAMCVsWCLp 429
Cdd:cd17474  209 LYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL----ALGSLFVGRLLKKR-----FGARRILVIGLLL-YAL- 277

                        330       340
                 ....*....|....*....|
gi 254583259 430 cGLFIFGWAASVHWMVPIAA 449
Cdd:cd17474  278 -SLLLLGFVPSLALLLIAIV 296
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
124-285 9.86e-16

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 78.80  E-value: 9.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 124 YTPGQEQIQQEFGV--GHVVATLnlSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVIL 201
Cdd:PRK11102  10 YLPALPVIAADFGVsaGSVQMTL--SAYILGFAIGQLFYGPMAD--SFGRKPVILGGTLVFALAAVACALAQTIDQLIYM 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 202 RFLTGVlcspSLATGAASIGDVVRPKY-----------VPILLGLwsgaayaAPCVGPLIGAAMVIAKNWRWIFWLLMWM 270
Cdd:PRK11102  86 RFLHGL----AAAAASVVINALMRDMFpkeefsrmmsfVTLVMTI-------APLLAPIIGGWLLVWFSWHAIFWVLALA 154

                        170
                 ....*....|....*.
gi 254583259 271 sALLLVTLIFFF-PET 285
Cdd:PRK11102 155 -AILAAALVFFFiPET 169
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
110-532 1.46e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 78.37  E-value: 1.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:COG2271   15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD--RFGRRRVLAIGLLLWGLATLLF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMW 269
Cdd:COG2271   93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 270 MSALLLVtlifffpetsednilhrrcerikkitgddryytfkareesklnakdIAIIALYrpfeimvkepivqaldIYIA 349
Cdd:COG2271  173 PGLLLAL----------------------------------------------LRFWLLA----------------LAYF 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFLVGSFVAYaasiIFLHYYADRKMANGTFTPETFLVLAMcvswclp 429
Cdd:COG2271  191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGS----LLGGWLSDRLGRRRKLVLAIGLLLAA------- 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 430 CGLFIFGWAASVHWMVPIAAelLFVMCDFNLWESIFSYLAVSYPKYVASVFAG--NGVLRAGFACAFPLFGKAmydnLAI 507
Cdd:COG2271  260 LALLLLALLPSPALAIALLF--LAGFGLGGAFGLLWALAAELFPKKARGTASGlvNTFGFLGGALGPLLVGYL----LDA 333

                        410       420
                 ....*....|....*....|....*
gi 254583259 508 DGYPVGWGSSLLGFITIGLALLPFL 532
Cdd:COG2271  334 TGYQAAFLLLAALALLAALLALLLL 358
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 110-533 3.47e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 74.15  E-value: 3.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD--RFGRKRLLLLGLLLLAVSTLLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMW 269
Cdd:cd17325   79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 270 MSALLLVTLIFFFPETsednilhrrceRIKKITGDDRYYTFKAREESKLNAKDIAIIALyrpfeimvkepivqaldiYIA 349
Cdd:cd17325  159 LALLALVLALLLLPEP-----------RPPPNKRAVSAARLRSGLRLLLRDRRLLALFL------------------AIF 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 350 LTYGIFYLFFESFPIVFSGIYHFTLIELGLSYLGFlvgsFVAYAASIIFLHYYADRkmangtFTPETFLVLAMCVswclp 429
Cdd:cd17325  210 VLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQ----GLASALSQPPAGKLSDR------IGRKPLILIGLLL----- 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 430 CGLFIFGWA-ASVHWMVPIAAELLFVMCDFnLWESIFSYLAVSYPKYV-ASVFAGNGVLRAGFACAFPLFGKAMYDNLai 507
Cdd:cd17325  275 SAVALLLLPlATSFWLLLLLLALLGLGLGL-VFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-- 351

                        410       420
                 ....*....|....*....|....*.
gi 254583259 508 dgypvGWGSSLLGFITIGLALLPFLF 533
Cdd:cd17325  352 -----GFATPFLAAAALLLLAAVLFL 372
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 110-276 4.30e-14

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 74.15  E-value: 4.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGhvvaTLNLSVYVIGYGIGPIIFSPLSEFAI--FGRQQLYIVTLFLFTMLQA 187
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGAS----LDTVQWVITSYLLALAIMIPLSGWLAdrFGTRRLFLTALALFTLGSL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 188 GCALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLL 267
Cdd:cd17503   77 LCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN 156


                 ....*....
gi 254583259 268 MWMSALLLV 276
Cdd:cd17503  157 LPIGILALL 165
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
112-288 5.10e-14

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 73.82  E-value: 5.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 112 LLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEFaiFGRQQLYIVTLFLFTMLQAGCAL 191
Cdd:PRK15402  20 LFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDR--IGRRPVMLAGVAFFILTCLAILL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 192 VHNIAGLVILRFLTGV-LCSPSlATGAASI------GDVVRpkyvpiLLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIF 264
Cdd:PRK15402  98 AQSIEQFTLLRFLQGIgLCFIG-AVGYAAIqesfeeADAIK------ITALMANVALLAPLLGPLVGAALIHVLPWRGMF 170

                        170       180
                 ....*....|....*....|....
gi 254583259 265 WLLMWMSALLLVTLIFFFPETSED 288
Cdd:PRK15402 171 VLFAALAALSFFGLWRAMPETAGR 194
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 110-266 8.37e-14

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 72.98  E-value: 8.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGD--RFGRKRVFLIGLALFGLASLLC 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWL 266
Cdd:cd17321   79 ALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI 155
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
102-536 1.06e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 69.91  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 102 KKTIVITEVSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFL 181
Cdd:COG2223    2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD--RFGPRRVLLIGLLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 182 FTMLQAGCALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWR 261
Cdd:COG2223   80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 262 WIFWLLMWMSALLLVTLIFFFPETSEDnilhrrcerikkitgddryytfkAREESKLNAKDIAiialyrpfeIMVKEPIV 341
Cdd:COG2223  160 NAFLILGILLLVVAVLAWLFLRDPPAG-----------------------AAAAAKASLRDQL---------EALRDPRF 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 342 QALDIYIALTYGIFYLFFESFPIVFSGIYHFTLIELG-LSYLGFLVGSFVAYAASIIflhyyADRkmangtFTPETFLVL 420
Cdd:COG2223  208 WLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGlLAALFALLGALGRPLGGWL-----SDR------IGGRRVLLI 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 421 AMCVSWclpCGLFIFGWAASVHWMVPIAAELLFVMCDFNLwESIFSYLAVSYP-KYVAS----VFAGNGVlrAGFacAFP 495
Cdd:COG2223  277 VFALMA---LGLLLLALALGSLWLFLVLFLLLGLALGGGN-GAVFALVPDIFPtKNAGAvyglVGAAGGL--GGF--LGP 348

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 254583259 496 LFGKAMYDnlAIDGYPVGWGsSLLGFITIGLALLPFLFYKY 536
Cdd:COG2223  349 LLFGALLD--ATGSYTAAFL-VFAVLALVALVLTLLLYRRP 386
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 105-283 1.25e-11

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 66.05  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 105 IVITEVSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTM 184
Cdd:cd17319    3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLD--RFGARKVLAVSMLLWSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 185 LQAGCALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIF 264
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160

                        170
                 ....*....|....*....
gi 254583259 265 WLLMWMSALLLVTLIFFFP 283
Cdd:cd17319  161 IIEGLLGLLLAVLWWFYLR 179
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 139-287 1.44e-11

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 66.63  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  139 HVVATLNLSVYVI-----GYGIGPIIFSPLSEFAI--FGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSP 211
Cdd:TIGR00711  27 TIAGDLGSSLSQVqwvitSYMLANAISIPLTGWLAkrFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGP 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254583259  212 SLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMWMSALLLVTLIFFFPETSE 287
Cdd:TIGR00711 107 LIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKP 182
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 131-301 2.03e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 65.84  E-value: 2.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  131 IQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCS 210
Cdd:TIGR00895  43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLAD--RIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLG 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  211 PSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMWMSALLLVTLIFFFPEtSEDNI 290
Cdd:TIGR00895 121 GLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPE-SIDFL 199

                         170
                  ....*....|.
gi 254583259  291 LHRRCERIKKI 301
Cdd:TIGR00895 200 VSKRPETVRRI 210
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 145-266 3.03e-09

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 58.73  E-value: 3.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 145 NLSVYVIGYGIGPIIFSPL--SEFAIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPSLATGAASIGD 222
Cdd:cd17502   31 LVSWVGTAYLLTSTAFQPIygKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIAD 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 254583259 223 VVRPKYVPILLGLWsGAAYAAPCV-GPLIGAAMVIAKNWRWIFWL 266
Cdd:cd17502  111 LVPPRERGKYQGYI-GAVFGIASVaGPLIGGAFTDHLSWRWCFYI 154
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 113-282 5.97e-09

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 58.41  E-value: 5.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 113 LTFITYMGSSIYTPGQ-EQIQQEFGvGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTmlqAGCAL 191
Cdd:cd06179    5 LAYFAQLFGVTLPAAVlPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSD--LFGRRWFFIGGNLLGV---VGSIV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 192 V---HNIAGLVILRFLTGVLCSPSLAtGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKN--WRWIFWL 266
Cdd:cd06179   79 AgtaKSVNMLIGGQALIGIGAGTQGL-GAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYI 157

                        170
                 ....*....|....*.
gi 254583259 267 LMWMSALLLVTLIFFF 282
Cdd:cd06179  158 NAIFNALALILLFFFY 173
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 133-278 1.54e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 56.44  E-value: 1.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 133 QEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEFaiFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPS 212
Cdd:cd17365   27 QDWGLSPAQLGPVGSAALFGMAIGALLAGPLADR--FGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 213 LATGAASIGDVVRPKyvpiLLGLWSGAAYAAPCVGP----LIGAAMVIAKNWRWIFWLLMWMSALLLVTL 278
Cdd:cd17365  105 MPNAITLVSEYAPAR----RRSLAVTLMFCGYPLGAalggFLAAALIPAFGWRSVFLLGGVPPLILLPLL 170
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 110-279 2.72e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 56.05  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGD--LYGRKKVLLIVLAIYTAGSLLA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVlcspSLATGAASIG---DVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWL 266
Cdd:cd17504   79 AFAPNLPVLIAGRALQGI----GGAVFPLAFAlvrEEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWT 154

                        170
                 ....*....|...
gi 254583259 267 lmwMSALLLVTLI 279
Cdd:cd17504  155 ---AAPVAVLLAA 164
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
111-289 4.67e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 55.28  E-value: 4.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 111 SLLTFI-TYMgssiYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:PRK11043  15 SMLGFLaTDM----YLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSD--RYGRKPVLLAGLSLFALGSLGM 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGV-LCSPSL-----------ATGAASIGDVVRPkyvpiLLGLwsgaayaAPCVGPLIGAAMVIA 257
Cdd:PRK11043  89 LWVESAAQLLVLRFVQAVgVCSAAViwqalvidrypAQKANRVFATIMP-----LVAL-------SPALAPLLGAWLLNH 156

                        170       180       190
                 ....*....|....*....|....*....|..
gi 254583259 258 KNWRWIFWLLMWMSALLLVTLIFFFPETSEDN 289
Cdd:PRK11043 157 FGWQAIFATLFAITLLLILPTLRLKPSKKARK 188
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 146-282 6.38e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.53  E-value: 6.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 146 LSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVR 225
Cdd:cd17316   42 FAAGFLGRPIGALLFGYLGD--RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAP 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254583259 226 PKYVPILLGL----WSGAAYAAPCVGPLIGAAMVIAKNWRWIFWL--------LMWMSALLLVTLIFFF 282
Cdd:cd17316  120 SKRRGFALGLlqsgWALGALLAALVASLLIPLLSGDWGWRILFLIgalpallaLLLRRRTLLLILLWFF 188
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 131-287 1.62e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 53.46  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 131 IQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEFaiFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCS 210
Cdd:cd17371   25 LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADR--FGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 211 PSLATGAASIGDVVRPKYVPILLGL--------WSGAAYAAPCVGPLIGAAMviakNWRWIFWLLMwMSALLLVTLIFFF 282
Cdd:cd17371  103 GEWAAGAALMAEYVPARHRGKALGYvqsgwavgWLLATLLAALLFPLLPPEI----AWRVLFLLGA-LPALLVLFIRRFV 177


                 ....*
gi 254583259 283 PETSE 287
Cdd:cd17371  178 KEPPQ 182
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
131-287 2.25e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.95  E-value: 2.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 131 IQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEFAIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCS 210
Cdd:COG2271  207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254583259 211 PSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMWMSALLLVTLIFFFPETSE 287
Cdd:COG2271  287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
112-285 4.17e-07

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 52.52  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 112 LLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEFaiFGRQQLYIVTLFLFTMLQAGCAL 191
Cdd:PRK15403  23 LYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDR--IGRRPVLITGALIFTLACAATLF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 192 VHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMWMS 271
Cdd:PRK15403 101 TTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMG 180

                        170
                 ....*....|....
gi 254583259 272 ALLLVTLIFFFPET 285
Cdd:PRK15403 181 LIAFVGLLLAMPET 194
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
130-288 6.89e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.78  E-value: 6.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 130 QIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGV-- 207
Cdd:COG0738   33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLID--RFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLgl 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 208 -LCSPSLATGAASIGDVVRPKYVPILLGLWSGAAyaapCVGPLIGAAMV---IAKNWRWIFWLLMWMSALLLVTLIFF-F 282
Cdd:COG0738  111 gLLDVAANPYVAALGPETAASRLNLLHAFFSLGA----LLGPLLGGLLIllgLSLSWHLPYLILAVLLLLLALLFLRSkL 186


                 ....*.
gi 254583259 283 PETSED 288
Cdd:COG0738  187 PEIEEE 192
emrD PRK11652
multidrug transporter EmrD;
119-285 7.84e-07

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 51.45  E-value: 7.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 119 MGSSIYTPGQEQIQQEFGV--GHVVATLnlSVYVIGYGIGPIIFSPLSEFaiFGRQQLYIVTLFLFtMLQAGCALV-HNI 195
Cdd:PRK11652  22 MAQTIYVPAIADMARDLNVreGAVQAVM--AAYLLTYGLSQLFYGPLSDR--VGRRPVILVGMSIF-ILGTLVALFaHSL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 196 AGLVILRFLTGvlcspsLATGAAsiGDVVRPKYVPILLG--------LWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLL 267
Cdd:PRK11652  97 TVLIAASAIQG------LGTGVG--GVMARTLPRDLYEGtqlrhansLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFL 168

                        170
                 ....*....|....*...
gi 254583259 268 MWMSALLLVTLIFFFPET 285
Cdd:PRK11652 169 LLLGAGVTFSMARWMPET 186
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 142-283 9.15e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 51.04  E-value: 9.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 142 ATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPSLATGAASIG 221
Cdd:cd17317   27 VALVQTIFFLGVLIGSLLFGYLAD--RFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGM 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254583259 222 DVVRPKY---VPILLGL-WSGAAYAAPCVGPLIgaamviaKNWRWIFWLLMWmSALLLVTLIFFFP 283
Cdd:cd17317  105 EIVGPKYrsfVGILFGLfWALGYMLLALLAYLI-------RDWRWLQLAISL-PGLLFLLLLWWLP 162
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 137-283 5.61e-06

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 48.78  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 137 VGHVVATLNlSVYVIGYGIGPIIFSPLSEFaiFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPSLATG 216
Cdd:cd17327   39 VGNQYNWGN-TVFYVGYIIFELPGNLLLQR--FPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGF 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254583259 217 AASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKN------WRWIFWLLMWMSALLLVTLIFFFP 283
Cdd:cd17327  116 ILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGvgglagWRWLFIIEGLITIIIGLVIFFWLP 188
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 110-282 7.36e-06

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 48.41  E-value: 7.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17476    3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGD--IYGHKKMFVIGSFWFAIWSLIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRP-KYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLM 268
Cdd:cd17476   81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160

                        170
                 ....*....|....
gi 254583259 269 WMSALLLVTLIFFF 282
Cdd:cd17476  161 ILAAIVAVAAIFWT 174
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 129-285 9.88e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 47.95  E-value: 9.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 129 EQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEFaiFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGvl 208
Cdd:cd17359   25 PFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADR--FGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGG-- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 209 cspsLATGAASigdVVRPKY------------------VPILLGLwSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMWM 270
Cdd:cd17359  101 ----LAVGGAS---ALVPMYiaevapaeirgrlvslnqLMIVFGQ-LLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIP 172

                        170
                 ....*....|....*
gi 254583259 271 SALLLVtLIFFFPET 285
Cdd:cd17359  173 AILFLL-GMLFIPES 186
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
129-283 2.31e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.79  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 129 EQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSefAIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVl 208
Cdd:COG2807   42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLA--RRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA- 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254583259 209 cspSLATG-AASIGDVVR--PKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRwifWLLMWMSALLLVTLIFFFP 283
Cdd:COG2807  119 ---GIAVGnVLLPGLIKRwfPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR---GALAVWALLALLALLLWLP 190
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 110-285 2.43e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.42  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGvghvvaTLNLSVYVIG-----YGIGPIIFSP----LSEfaIFGRQQLYIVTLF 180
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFN------KLGASGYYVGllqssYSLGQFLASPlwgrLSD--RYGRKPVLLLSLA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 181 LFTMLQAGCALVHNIAGLVILRFLTGVLCSpSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNW 260
Cdd:cd17330   73 GSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 254583259 261 RWIFW----------LLMW-----MSALLLVTLIFFFPET 285
Cdd:cd17330  152 ALPFLvaaalallnlVLVLfflppLRRLLLVYFLIALAFA 191
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 169-465 2.88e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 46.44  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 169 FGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFL--TGVLCSPSLATGAASIGDVVRPKYVPIlLGLWSGAAYAAPCV 246
Cdd:cd17472   59 IGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALqgSGAISSVVMALLADLTREENRTKAMAL-IGASIGIAFAISMV 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 247 -GPLIGAAMVIaknwRWIFWLLMWMSALLLVTLIFFFPEtsEDNILHRRCERIKKITGddryytfkareesklnakdiai 325
Cdd:cd17472  138 lGPLLAAHLGV----SGLFLITAILSLVSLLILLFFVPD--PPKIVQISEKEKKKLKK---------------------- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 326 ialyrpfeiMVKEPIVQALDIYIALTYGIFYLFFESFPIVFSGIYHfTLIELGLSYLGFLVGSFVAYAASIIFLHYYadR 405
Cdd:cd17472  190 ---------LLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGG-GKGQLWKVYLPAILIGFILMVPFVIYAEKK--G 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 406 KMangtftpetFLVLAMCVSWCLPCGLFIFGWAASVhWMVPIAAELLFVmcDFNLWESIF 465
Cdd:cd17472  258 KM---------KQVFVSSILLIAVGFLLLLFAATSL-WLLIIGLIIFFI--GFNLLEALL 305
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 133-285 5.16e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.68  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 133 QEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPS 212
Cdd:cd17329   28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLAD--RFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254583259 213 LATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAkNWRWIFWLLMWMSALLLVTLIFFFPET 285
Cdd:cd17329  106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPET 177
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 110-287 9.56e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.89  E-value: 9.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 110 VSLLTFITYMGSSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGygigPIIFSPLSEFAI--FGRQQLYIVTLFLFTMLQA 187
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLA----ALLARPFAGRLLdrFGRKRLLLIGLLIFALATL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 188 GCALVHNIAGLVILRFLTGV---LCSPSLATGAASIGDVVRPKYVpilLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIF 264
Cdd:cd17489   77 LYLLATSVALLLVLRLIHGIgwgAFTTAAATLVADIIPPSRRGEG---IGYYGLATTLAMALGPALGLFLYQHLGFAVLF 153

                        170       180
                 ....*....|....*....|...
gi 254583259 265 WLLMWMSALLLVtLIFFFPETSE 287
Cdd:cd17489  154 IVAAVLALLALL-LVFLVKDPPP 175
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 168-286 1.20e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.57  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 168 IFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGV-----------LCSPslATGAASIGDVVRPKY--VPIllg 234
Cdd:PRK11551  76 RIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVglggalpnliaLTSE--AVGPRLRGTAVSLMYcgVPF--- 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 254583259 235 lwsGAAYAApcvgpLIGAAMVIAKNWRWIFWLLMWMSALLLVTLIFFFPETS 286
Cdd:PRK11551 151 ---GGALAS-----VIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESR 194
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 112-285 1.37e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.49  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 112 LLTFITYMGSSIYTPGQEQIQQEFgVGHVVATLNLSVYVigYGIGPIIFSPLSEFAI--FGRQQLYIVTLFLFTMLQAGC 189
Cdd:cd17473    6 LASTLTVMAGAAIAPALPAIAQHF-VPNSELLVPLLLTL--PALFIALFAPLAGWLAdrFGRKRLLIAGLLLYGIGGVAG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMViAKNWRWIFwLLMW 269
Cdd:cd17473   83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPF-LVYL 160

                        170
                 ....*....|....*.
gi 254583259 270 MSALLLVTLIFFFPET 285
Cdd:cd17473  161 LALPVLILVLLFLPEP 176
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 169-283 2.11e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 43.89  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  169 FGRQQLYIVTLFLftmlqagcALVHNIAGLVILRF--------LTGVLCSPSLATgAASIGDVVRPKYVPILLGLWSGAA 240
Cdd:pfam06609 105 FGRRPFVIATHII--------GLVGAIVGCTANKFntllaamtLLGVAAGPAGAS-PLFIGELMSNKTKFLGLLIVSAPT 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 254583259  241 YAAPCVGPLIGAAMVIAKNWRWIFWLLMWMSAL-LLVTLIFFFP 283
Cdd:pfam06609 176 IAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIaVLLIIIWYHP 219
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
89-243 4.78e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259  89 PEDPEHPHNWSTLKKTIVITEVSLLTFITYMG-SSIYTPGQEQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEFa 167
Cdd:COG2814  191 AARARLRGSLRELLRRPRLLLLLLLAFLLGFGfFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR- 269

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254583259 168 iFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAA 243
Cdd:COG2814  270 -FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 130-479 8.19e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.92  E-value: 8.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 130 QIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGvLC 209
Cdd:cd17333   21 SLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMK--RLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAG-LG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 210 SPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKN-WRWIFW-LLMWMSALLLVTLIFFFPETSE 287
Cdd:cd17333   98 AGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELsWSWAYLiIGLIYLLLAILILLTLFPELPS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 288 DNILHRRCERIKKITGDdryytfkareesklnakdiaiialyrpfeiMVKEPIVQALDIYIALTYGIFYLFFESFPIVFS 367
Cdd:cd17333  178 ARNPQQSVGAFSASASR------------------------------LLRNPSIILGALALFLYVGAETAFSSWVPSYLV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 368 GIYHFTLIELGLSYLGFLVGSFVAYAASIIFLHyyadrkmangTFTPETFLVLAmCVSWCLpcGLFIFGWAASVHWMVPI 447
Cdd:cd17333  228 EKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR----------RIKPHTLLVLS-GSGALL--GLLILLLAPTLVVGLVA 294

                        330       340       350
                 ....*....|....*....|....*....|..
gi 254583259 448 AAELLFVMCdfNLWESIFSYLAVSYPKYVASV 479
Cdd:cd17333  295 TALLGLFMA--ALFPTILSLGISNLPYAKGKG 324
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 138-285 4.47e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.48  E-value: 4.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 138 GHVVATLnlsvyVIGYGIGPIIFSPLSEFaiFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCspSLATGA 217
Cdd:cd17315   37 GLVVSSL-----LLGAAIGSLFGGPLADR--FGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGV--GLASVL 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254583259 218 AS--IGDVVRPKYVPILLGLW----SGAAYAAPCVGplIGAAMVIAKNWRWIFWLLMwMSALLLVTLIFFFPET 285
Cdd:cd17315  108 VPlyISEIAPAKIRGALGTLNqlmiTFGILLAYLLG--LALSLSPPGWWRLMFALAA-VPALLQLLLMFFLPES 178
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 129-284 5.67e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 39.14  E-value: 5.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 129 EQIQQEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEfaIFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGV- 207
Cdd:cd17328   23 PDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGD--RYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIg 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 208 --LCSPSLATgaaSIGDVVRPK---------YVPILLGlwSGAAYAapcVGPLIGAAmviAKNWRWIFwLLMWMSALLLV 276
Cdd:cd17328  101 eaSYSPIAPT---IIADLFPKEkrtralgvfYFAIPLG--SGLGYV---VGGLVAQA---TGGWRWAF-RVTGVLGVLLA 168


                 ....*...
gi 254583259 277 TLIFFFPE 284
Cdd:cd17328  169 ILLLLFVR 176
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 144-529 6.23e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 6.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 144 LNLSVYVIGYGIGPIIFSPLS-EFA-IFGRQQLYIVTLFLFTMLQAGCALVH-----NIAGLVILRFLTGVLCSPSLATG 216
Cdd:cd06173   34 LLVGLVLAAFFLPFLLFSPFAgVLAdRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPAR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 217 AASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLMwMSALLLVTLIFFFPETSEDNILHRRCE 296
Cdd:cd06173  114 QALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA-LSFLLSALLLLFIRRPPPAAPGESSSL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 297 RIKKITGDDRYYtfkareesklnakdiaiialyrpfeimVKEPIVQALDIYIALTYGIFYLFFESFPIVFSGIYHFTLIE 376
Cdd:cd06173  193 LLRDLREGLRYL---------------------------RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 377 LGL----SYLGFLVGSFVAYAASiiflhyyadrkmanGTFTPETFLVLAMCVswclpCGLFIFGWAASVHWMVPIAAELL 452
Cdd:cd06173  246 YGLllaaFGVGALLGALLLGRLS--------------KRRRRGRLLLIGALL-----LGLALLVLGLSPSLWLLLAALFL 306

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254583259 453 FVMCdfnlWESIFSYLAVSYPKYVASVFAG--NGVLRAGFACAFPLfGKAMYdNLAIDGYPVGWGSSLLGFITIGLALL 529
Cdd:cd06173  307 LGLA----GGLFNVPLNTLLQLRVPDELRGrvFSVYNALNSGAMPL-GALLA-GLLADALGLSAVFLLAGALLLLAALL 379
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 111-283 7.65e-03

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 38.76  E-value: 7.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 111 SLLTFITYMGSSIYTPGQEQIQQEFGVghvvATLNLSVYVIGYGIGPIIFSPLseFAIFGRQQLYIVTLFLFTMLQA-GC 189
Cdd:cd17336    9 CLLGLLQGAVVSYFVSTITTIEKRFGL----SSSQSGLILSANDIGQLLAVLL--VSYFGGRGHRPRWIGIGSILMGlGC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 190 ---ALVHniaGLVILRFLTGVLCSPSLATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMV----------- 255
Cdd:cd17336   83 fllALPH---FLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLriyvdfsrvpl 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 254583259 256 --IAKNWRWI-FWLLMW--MSALLLVT--LIFFFP 283
Cdd:cd17336  160 giTPDDPRWIgAWWLGFliLGILLLIVsiPLFFFP 194
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 133-282 8.75e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 8.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 133 QEFGVGHVVATLNLSVYVIGYGIGPIIFSPLSEFAiFGRQQLYIVTLFLFTMLQAGCALVHNIAGLVILRFLTGVLCSPS 212
Cdd:cd17474  227 LLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR-FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLN 305

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254583259 213 LATGAASIGDVVRPKYVPILLGLWSGAAYAAPCVGPLIGAAMVIAKNWRWIFWLLmwmSALLLVTLIFFF 282
Cdd:cd17474  306 LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVG---AAIALAAAVLLA 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH